Organism Overview: Homo sapiens


 
ARF5 protein networkhttps://string-db.org/network/9606.ENSP00000000233ADP-ribosylation factor 5; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf [...]
M6PR protein networkhttps://string-db.org/network/9606.ENSP00000000412Cation-dependent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl re [...]
FKBP4 protein networkhttps://string-db.org/network/9606.ENSP00000001008Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction [...]
CYP26B1 protein networkhttps://string-db.org/network/9606.ENSP00000001146Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic [...]
NDUFAF7 protein networkhttps://string-db.org/network/9606.ENSP00000002125Protein arginine methyltransferase NDUFAF7, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Ac [...]
FUCA2 protein networkhttps://string-db.org/network/9606.ENSP00000002165Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoprote [...]
HS3ST1 protein networkhttps://string-db.org/network/9606.ENSP00000002596Heparan sulfate glucosamine 3-O-sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine res [...]
SEMA3F protein networkhttps://string-db.org/network/9606.ENSP00000002829Semaphorin-3F; May play a role in cell motility and cell adhesion.
CFTR protein networkhttps://string-db.org/network/9606.ENSP00000003084Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates th [...]
CYP51A1 protein networkhttps://string-db.org/network/9606.ENSP00000003100Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequen [...]
USP28 protein networkhttps://string-db.org/network/9606.ENSP00000003302Ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deub [...]
SLC7A2 protein networkhttps://string-db.org/network/9606.ENSP00000004531Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between is [...]
HSPB6 protein networkhttps://string-db.org/network/9606.ENSP00000004982Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functio [...]
PDK4 protein networkhttps://string-db.org/network/9606.ENSP00000005178[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation [...]
USH1C protein networkhttps://string-db.org/network/9606.ENSP00000005226Harmonin; USH1 protein network component harmonin.
RALA protein networkhttps://string-db.org/network/9606.ENSP00000005257Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane [...]
BAIAP2L1 protein networkhttps://string-db.org/network/9606.ENSP00000005260Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganiz [...]
CACNG3 protein networkhttps://string-db.org/network/9606.ENSP00000005284Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes thei [...]
TMEM132A protein networkhttps://string-db.org/network/9606.ENSP00000005286Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-i [...]
DVL2 protein networkhttps://string-db.org/network/9606.ENSP00000005340Segment polarity protein dishevelled homolog DVL-2; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling [...]
RPAP3 protein networkhttps://string-db.org/network/9606.ENSP00000005386RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to r [...]
SKAP2 protein networkhttps://string-db.org/network/9606.ENSP00000005587Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a r [...]
PRSS21 protein networkhttps://string-db.org/network/9606.ENSP00000005995Testisin; Could regulate proteolytic events associated with testicular germ cell maturation.
HOXA11 protein networkhttps://string-db.org/network/9606.ENSP00000006015Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
CX3CL1 protein networkhttps://string-db.org/network/9606.ENSP00000006053Processed fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1. Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR [...]
TRAPPC6A protein networkhttps://string-db.org/network/9606.ENSP00000006275Trafficking protein particle complex subunit 6A; May play a role in vesicular transport during the biogenesis of melanosomes.
WDR54 protein networkhttps://string-db.org/network/9606.ENSP00000006526WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EG [...]
SPATA20 protein networkhttps://string-db.org/network/9606.ENSP00000006658Spermatogenesis-associated protein 20; May play a role in fertility regulation.
CEACAM7 protein networkhttps://string-db.org/network/9606.ENSP00000006724CEA cell adhesion molecule 7; Belongs to the immunoglobulin superfamily. CEA family.
RHBDD2 protein networkhttps://string-db.org/network/9606.ENSP00000006777Rhomboid domain containing 2; Belongs to the peptidase S54 family.
TSR3 protein networkhttps://string-db.org/network/9606.ENSP00000007390Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.
OSBPL7 protein networkhttps://string-db.org/network/9606.ENSP00000007414Oxysterol binding protein like 7; Belongs to the OSBP family.
YBX2 protein networkhttps://string-db.org/network/9606.ENSP00000007699Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box cons [...]
KRT33A protein networkhttps://string-db.org/network/9606.ENSP00000007735Keratin, type I cuticular Ha3-I; Keratin 33A; Belongs to the intermediate filament family.
TFAP2D protein networkhttps://string-db.org/network/9606.ENSP00000008391Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...]
CRY1 protein networkhttps://string-db.org/network/9606.ENSP00000008527Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes thro [...]
PGLYRP1 protein networkhttps://string-db.org/network/9606.ENSP00000008938Peptidoglycan recognition protein 1; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...]
STARD3NL protein networkhttps://string-db.org/network/9606.ENSP00000009041STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic [...]
CAMK1G protein networkhttps://string-db.org/network/9606.ENSP00000009105Calcium/calmodulin-dependent protein kinase type 1G; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription [...]
CD74 protein networkhttps://string-db.org/network/9606.ENSP00000009530HLA class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after [...]
FAM76A protein networkhttps://string-db.org/network/9606.ENSP00000010299Protein FAM76A; Family with sequence similarity 76 member A.
CPA1 protein networkhttps://string-db.org/network/9606.ENSP00000011292Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family.
SYPL1 protein networkhttps://string-db.org/network/9606.ENSP00000011473Synaptophysin-like protein 1; Synaptophysin like 1; Belongs to the synaptophysin/synaptobrevin family.
RANBP9 protein networkhttps://string-db.org/network/9606.ENSP00000011619Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Acts as a mediator of cell spreading and [...]
CD4 protein networkhttps://string-db.org/network/9606.ENSP00000011653T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal o [...]
TSPAN9 protein networkhttps://string-db.org/network/9606.ENSP00000011898Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family.
QPCTL protein networkhttps://string-db.org/network/9606.ENSP00000012049Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides.
PPP5C protein networkhttps://string-db.org/network/9606.ENSP00000012443Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1 [...]
UBR7 protein networkhttps://string-db.org/network/9606.ENSP00000013070Putative E3 ubiquitin-protein ligase UBR7; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that [...]
MAP4K5 protein networkhttps://string-db.org/network/9606.ENSP00000013125Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kin [...]
INMT protein networkhttps://string-db.org/network/9606.ENSP00000013222Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-meth [...]
ERCC1 protein networkhttps://string-db.org/network/9606.ENSP00000013807DNA excision repair protein ERCC-1; [Isoform 1]: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunc [...]
GPRC5A protein networkhttps://string-db.org/network/9606.ENSP00000014914Retinoic acid-induced protein 3; Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide eviden [...]
HEBP1 protein networkhttps://string-db.org/network/9606.ENSP00000014930Heme-binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of [...]
COX15 protein networkhttps://string-db.org/network/9606.ENSP00000016171Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A. Belongs to the COX15/CtaA family.
MS4A12 protein networkhttps://string-db.org/network/9606.ENSP00000016913Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
RGPD5 protein networkhttps://string-db.org/network/9606.ENSP00000016946RANBP2-like and GRIP domain-containing protein 5/6; RANBP2 like and GRIP domain containing 5.
XYLT2 protein networkhttps://string-db.org/network/9606.ENSP00000017003Xylosyltransferase 2; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to [...]
SCTR protein networkhttps://string-db.org/network/9606.ENSP00000019103Secretin receptor; Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of t [...]
SYT13 protein networkhttps://string-db.org/network/9606.ENSP00000020926Synaptotagmin-13; May be involved in transport vesicle docking to the plasma membrane; Belongs to the synaptotagmin family.
SNAI2 protein networkhttps://string-db.org/network/9606.ENSP00000020945Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role [...]
SLC7A9 protein networkhttps://string-db.org/network/9606.ENSP00000023064B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be respo [...]
RTF2 protein networkhttps://string-db.org/network/9606.ENSP00000023939Replication termination factor 2; Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive [...]
RB1CC1 protein networkhttps://string-db.org/network/9606.ENSP00000025008RB1-inducible coiled-coil protein 1; Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the format [...]
AKAP11 protein networkhttps://string-db.org/network/9606.ENSP00000025301A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family.
PIGQ protein networkhttps://string-db.org/network/9606.ENSP00000026218Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...]
CDH17 protein networkhttps://string-db.org/network/9606.ENSP00000027335Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
B4GALT7 protein networkhttps://string-db.org/network/9606.ENSP00000029410Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glyc [...]
FAM13B protein networkhttps://string-db.org/network/9606.ENSP00000033079Protein FAM13B; Family with sequence similarity 13 member B.
CHPF2 protein networkhttps://string-db.org/network/9606.ENSP00000035307Chondroitin sulfate glucuronyltransferase; Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has n [...]
GABARAPL2 protein networkhttps://string-db.org/network/9606.ENSP00000037243Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAR [...]
MYOC protein networkhttps://string-db.org/network/9606.ENSP00000037502Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matri [...]
OTC protein networkhttps://string-db.org/network/9606.ENSP00000039007Ornithine carbamoyltransferase, mitochondrial; Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
TTC17 protein networkhttps://string-db.org/network/9606.ENSP00000039989Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization.
HOXC8 protein networkhttps://string-db.org/network/9606.ENSP00000040584Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
MRI1 protein networkhttps://string-db.org/network/9606.ENSP00000040663Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activi [...]
BOD1L1 protein networkhttps://string-db.org/network/9606.ENSP00000040738Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent [...]
TARBP1 protein networkhttps://string-db.org/network/9606.ENSP00000040877Probable methyltransferase TARBP1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs.
RTN4R protein networkhttps://string-db.org/network/9606.ENSP00000043402Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By [...]
PSMA4 protein networkhttps://string-db.org/network/9606.ENSP00000044462Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
RIPOR3 protein networkhttps://string-db.org/network/9606.ENSP00000045083RIPOR family member 3.
ZPBP protein networkhttps://string-db.org/network/9606.ENSP00000046087Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity).
LCP2 protein networkhttps://string-db.org/network/9606.ENSP00000046794Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling.
DCN protein networkhttps://string-db.org/network/9606.ENSP00000052754Decorin; May affect the rate of fibrils formation.
TNFRSF17 protein networkhttps://string-db.org/network/9606.ENSP00000053243Tumor necrosis factor receptor superfamily member 17; Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates [...]
MRPS10 protein networkhttps://string-db.org/network/9606.ENSP00000053468Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.
GUCA1A protein networkhttps://string-db.org/network/9606.ENSP00000053469Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevat [...]
GRN protein networkhttps://string-db.org/network/9606.ENSP00000053867Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein traffick [...]
THAP3 protein networkhttps://string-db.org/network/9606.ENSP00000054650THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.
VAMP3 protein networkhttps://string-db.org/network/9606.ENSP00000054666Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
UTS2 protein networkhttps://string-db.org/network/9606.ENSP00000054668Urotensin-2; Highly potent vasoconstrictor; Belongs to the urotensin-2 family.
RCN1 protein networkhttps://string-db.org/network/9606.ENSP00000054950Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family.
RFC2 protein networkhttps://string-db.org/network/9606.ENSP00000055077Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...]
PPP1R3F protein networkhttps://string-db.org/network/9606.ENSP00000055335Protein phosphatase 1 regulatory subunit 3F; Glycogen-targeting subunit for protein phosphatase 1 (PP1).
NEXMIF protein networkhttps://string-db.org/network/9606.ENSP00000055682Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding gen [...]
ARHGEF5 protein networkhttps://string-db.org/network/9606.ENSP00000056217Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and [...]
NFE2L3 protein networkhttps://string-db.org/network/9606.ENSP00000056233Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression.
TLL1 protein networkhttps://string-db.org/network/9606.ENSP00000061240Tolloid-like protein 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, whic [...]
CBLN4 protein networkhttps://string-db.org/network/9606.ENSP00000064571Cerebellin-4; Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for the formation and maintenance of inhibitory GABAergic synapses (By similarity [...]
CLDN11 protein networkhttps://string-db.org/network/9606.ENSP00000064724Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
FAM168A protein networkhttps://string-db.org/network/9606.ENSP00000064778Protein FAM168A; In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decre [...]
RELT protein networkhttps://string-db.org/network/9606.ENSP00000064780Tumor necrosis factor receptor superfamily member 19L; May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel fo [...]
PKP2 protein networkhttps://string-db.org/network/9606.ENSP00000070846Plakophilin-2; May play a role in junctional plaques.
YIPF1 protein networkhttps://string-db.org/network/9606.ENSP00000072644Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family.
ADCK2 protein networkhttps://string-db.org/network/9606.ENSP00000072869Uncharacterized aarF domain-containing protein kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosp [...]
INPP4A protein networkhttps://string-db.org/network/9606.ENSP00000074304Inositol polyphosphate-4-phosphatase type I A; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trispho [...]
SLC2A3 protein networkhttps://string-db.org/network/9606.ENSP00000075120Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Med [...]
STYK1 protein networkhttps://string-db.org/network/9606.ENSP00000075503Tyrosine-protein kinase STYK1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion [...]
GNA11 protein networkhttps://string-db.org/network/9606.ENSP00000078429Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as [...]
CREB3L3 protein networkhttps://string-db.org/network/9606.ENSP00000078445Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target gene [...]
HDAC7 protein networkhttps://string-db.org/network/9606.ENSP00000080059Histone deacetylase 7; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
MRPS35 protein networkhttps://string-db.org/network/9606.ENSP00000081029Mitochondrial ribosomal protein S35.
APPBP2 protein networkhttps://string-db.org/network/9606.ENSP00000083182Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.
CA11 protein networkhttps://string-db.org/network/9606.ENSP00000084798Carbonic anhydrase-related protein 11; Does not have a catalytic activity.
ISOC2 protein networkhttps://string-db.org/network/9606.ENSP00000085068Isochorismatase domain containing 2.
CD22 protein networkhttps://string-db.org/network/9606.ENSP00000085219B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially [...]
GSC2 protein networkhttps://string-db.org/network/9606.ENSP00000086933Homeobox protein goosecoid-2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC; Belongs to the paired homeobox family. Bicoid subf [...]
ZFY protein networkhttps://string-db.org/network/9606.ENSP00000155093Zinc finger Y-chromosomal protein; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3'.
KCNQ1 protein networkhttps://string-db.org/network/9606.ENSP00000155840Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Assoc [...]
TRPM5 protein networkhttps://string-db.org/network/9606.ENSP00000155858Transient receptor potential cation channel subfamily M member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays [...]
TRIB2 protein networkhttps://string-db.org/network/9606.ENSP00000155926Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr [...]
OTUD5 protein networkhttps://string-db.org/network/9606.ENSP00000156084OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I int [...]
GPKOW protein networkhttps://string-db.org/network/9606.ENSP00000156109G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing.
AQR protein networkhttps://string-db.org/network/9606.ENSP00000156471RNA helicase aquarius; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleo [...]
ST6GALNAC1 protein networkhttps://string-db.org/network/9606.ENSP00000156626ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1.
LMCD1 protein networkhttps://string-db.org/network/9606.ENSP00000157600LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstrea [...]
PSMC4 protein networkhttps://string-db.org/network/9606.ENSP0000015781226S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
FNDC8 protein networkhttps://string-db.org/network/9606.ENSP00000158009Fibronectin type III domain containing 8.
ACAP1 protein networkhttps://string-db.org/network/9606.ENSP00000158762Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins fr [...]
DERL2 protein networkhttps://string-db.org/network/9606.ENSP00000158771Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel [...]
NOX3 protein networkhttps://string-db.org/network/9606.ENSP00000159060NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline st [...]
ANO8 protein networkhttps://string-db.org/network/9606.ENSP00000159087Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity.
KDM4B protein networkhttps://string-db.org/network/9606.ENSP00000159111Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys- [...]
ICAM3 protein networkhttps://string-db.org/network/9606.ENSP00000160262Intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association [...]
CTTNBP2 protein networkhttps://string-db.org/network/9606.ENSP00000160373Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
ACTL6B protein networkhttps://string-db.org/network/9606.ENSP00000160382Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remode [...]
KIF22 protein networkhttps://string-db.org/network/9606.ENSP00000160827Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarit [...]
PRSS22 protein networkhttps://string-db.org/network/9606.ENSP00000161006Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu-Thr- Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA.
CEACAM1 protein networkhttps://string-db.org/network/9606.ENSP00000161559Carcinoembryonic antigen-related cell adhesion molecule 1; [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role [...]
YTHDC2 protein networkhttps://string-db.org/network/9606.ENSP000001618633'-5' RNA helicase YTHDC2; 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognize [...]
TMEM161A protein networkhttps://string-db.org/network/9606.ENSP00000162044Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis.
FOXJ2 protein networkhttps://string-db.org/network/9606.ENSP00000162391Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.
TNFRSF1A protein networkhttps://string-db.org/network/9606.ENSP00000162749Tumor necrosis factor receptor superfamily member 1A, membrane form; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the a [...]
GOLGA5 protein networkhttps://string-db.org/network/9606.ENSP00000163416Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.
CELSR3 protein networkhttps://string-db.org/network/9606.ENSP00000164024Cadherin EGF LAG seven-pass G-type receptor 3; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. [...]
PPP2R5B protein networkhttps://string-db.org/network/9606.ENSP00000164133Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate s [...]
PYGM protein networkhttps://string-db.org/network/9606.ENSP00000164139Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their [...]
BCL3 protein networkhttps://string-db.org/network/9606.ENSP00000164227B-cell lymphoma 3 protein; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subun [...]
PIGB protein networkhttps://string-db.org/network/9606.ENSP00000164305GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor asse [...]
PRLH protein networkhttps://string-db.org/network/9606.ENSP00000165524Prolactin-releasing peptide PrRP20; Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.
FSTL3 protein networkhttps://string-db.org/network/9606.ENSP00000166139Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activi [...]
EPHA8 protein networkhttps://string-db.org/network/9606.ENSP00000166244Ephrin type-A receptor 8; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
TRIP13 protein networkhttps://string-db.org/network/9606.ENSP00000166345Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that lea [...]
VASH1 protein networkhttps://string-db.org/network/9606.ENSP00000167106Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spind [...]
KRT14 protein networkhttps://string-db.org/network/9606.ENSP00000167586Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in r [...]
KRT20 protein networkhttps://string-db.org/network/9606.ENSP00000167588Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the [...]
SPP2 protein networkhttps://string-db.org/network/9606.ENSP00000168148Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover.
HSD17B10 protein networkhttps://string-db.org/network/9606.ENSP000001682163-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activ [...]
FGF4 protein networkhttps://string-db.org/network/9606.ENSP00000168712Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve developmen [...]
ST6GAL1 protein networkhttps://string-db.org/network/9606.ENSP00000169298Beta-galactoside alpha-2,6-sialyltransferase 1; Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates.
TIMM21 protein networkhttps://string-db.org/network/9606.ENSP00000169551Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for [...]
BPIFB2 protein networkhttps://string-db.org/network/9606.ENSP00000170150BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
REXO1 protein networkhttps://string-db.org/network/9606.ENSP00000170168RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro; Belongs to the REXO1/REXO3 family.
MKRN2 protein networkhttps://string-db.org/network/9606.ENSP00000170447Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
GPATCH1 protein networkhttps://string-db.org/network/9606.ENSP00000170564G-patch domain containing 1; Belongs to the GPATCH1 family.
P2RY10 protein networkhttps://string-db.org/network/9606.ENSP00000171757Putative P2Y purinoceptor 10; Putative receptor for purines coupled to G-proteins.
TNS1 protein networkhttps://string-db.org/network/9606.ENSP00000171887Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
NGFR protein networkhttps://string-db.org/network/9606.ENSP00000172229Tumor necrosis factor receptor superfamily member 16; Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms [...]
NTN1 protein networkhttps://string-db.org/network/9606.ENSP00000173229Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectiv [...]
ISOC1 protein networkhttps://string-db.org/network/9606.ENSP00000173527Isochorismatase domain containing 1.
TRO protein networkhttps://string-db.org/network/9606.ENSP00000173898Trophinin; Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo [...]
MNT protein networkhttps://string-db.org/network/9606.ENSP00000174618Max-binding protein MNT; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
LAPTM4A protein networkhttps://string-db.org/network/9606.ENSP00000175091Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound comp [...]
ADAM7 protein networkhttps://string-db.org/network/9606.ENSP00000175238Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metallo [...]
PTPN18 protein networkhttps://string-db.org/network/9606.ENSP00000175756Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
DRD4 protein networkhttps://string-db.org/network/9606.ENSP00000176183D(4) dopamine receptor; Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by [...]
SCT protein networkhttps://string-db.org/network/9606.ENSP00000176195Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin re [...]
STK10 protein networkhttps://string-db.org/network/9606.ENSP00000176763Serine/threonine-protein kinase 10; Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte mig [...]
TBX21 protein networkhttps://string-db.org/network/9606.ENSP00000177694T-box transcription factor TBX21; Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repres [...]
MRPS34 protein networkhttps://string-db.org/network/9606.ENSP0000017774228S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for m [...]
CA12 protein networkhttps://string-db.org/network/9606.ENSP00000178638Carbonic anhydrase 12; Reversible hydration of carbon dioxide. Belongs to the alpha-carbonic anhydrase family.
MAP2K5 protein networkhttps://string-db.org/network/9606.ENSP00000178640Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to p [...]
TIGAR protein networkhttps://string-db.org/network/9606.ENSP00000179259Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intra [...]
FGF20 protein networkhttps://string-db.org/network/9606.ENSP00000180166Fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function.
MTMR7 protein networkhttps://string-db.org/network/9606.ENSP00000180173Myotubularin-related protein 7; Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2).
CPB2 protein networkhttps://string-db.org/network/9606.ENSP00000181383Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down [...]
FAM107B protein networkhttps://string-db.org/network/9606.ENSP00000181796Protein FAM107B; Family with sequence similarity 107 member B.
CDK13 protein networkhttps://string-db.org/network/9606.ENSP00000181839Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptid [...]
TSPAN32 protein networkhttps://string-db.org/network/9606.ENSP00000182290Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family.
TRAM2 protein networkhttps://string-db.org/network/9606.ENSP00000182527Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This couplin [...]
ROPN1 protein networkhttps://string-db.org/network/9606.ENSP00000184183Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capaci [...]
NDUFB4 protein networkhttps://string-db.org/network/9606.ENSP00000184266NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
HEATR6 protein networkhttps://string-db.org/network/9606.ENSP00000184956HEAT repeat-containing protein 6; Amplification-dependent oncogene.
ERLEC1 protein networkhttps://string-db.org/network/9606.ENSP00000185150Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-assoc [...]
CLIC5 protein networkhttps://string-db.org/network/9606.ENSP00000185206Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarit [...]
TMEM131 protein networkhttps://string-db.org/network/9606.ENSP00000186436Transmembrane protein 131; May play a role in the immune response to viral infection. Belongs to the TMEM131 family.
TMEM38A protein networkhttps://string-db.org/network/9606.ENSP00000187762Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions [...]
ACTR6 protein networkhttps://string-db.org/network/9606.ENSP00000188312Actin related protein 6; Belongs to the actin family. ARP6 subfamily.
FAP protein networkhttps://string-db.org/network/9606.ENSP00000188790Antiplasmin-cleaving enzyme FAP, soluble form; Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including ti [...]
DMRT3 protein networkhttps://string-db.org/network/9606.ENSP00000190165Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal spe [...]
GAL3ST2 protein networkhttps://string-db.org/network/9606.ENSP00000192314Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non- reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3- GlcNAc) and type 2 (Gal-beta- [...]
UHRF1BP1 protein networkhttps://string-db.org/network/9606.ENSP00000192788UHRF1-binding protein 1; May act as a negative regulator of cell growth.
OSTM1 protein networkhttps://string-db.org/network/9606.ENSP00000193322Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function; Belongs to the OSTM1 family.
IMPG2 protein networkhttps://string-db.org/network/9606.ENSP00000193391Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and [...]
SLC13A1 protein networkhttps://string-db.org/network/9606.ENSP00000194130Solute carrier family 13 member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
PCDHB4 protein networkhttps://string-db.org/network/9606.ENSP00000194152Protocadherin beta-4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB2 protein networkhttps://string-db.org/network/9606.ENSP00000194155Protocadherin beta-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
HSPB11 protein networkhttps://string-db.org/network/9606.ENSP00000194214Intraflagellar transport protein 25 homolog; Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and [...]
STRADB protein networkhttps://string-db.org/network/9606.ENSP00000194530STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typ [...]
PLOD1 protein networkhttps://string-db.org/network/9606.ENSP00000196061Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for [...]
OXCT1 protein networkhttps://string-db.org/network/9606.ENSP00000196371Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA interm [...]
ZNF416 protein networkhttps://string-db.org/network/9606.ENSP00000196489Zinc finger protein 416; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FAM234B protein networkhttps://string-db.org/network/9606.ENSP00000197268Protein FAM234B; Family with sequence similarity 234 member B.
PILRA protein networkhttps://string-db.org/network/9606.ENSP00000198536Paired immunoglobulin-like type 2 receptor alpha; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PI [...]
RRN3 protein networkhttps://string-db.org/network/9606.ENSP00000198767RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation comp [...]
MOGAT2 protein networkhttps://string-db.org/network/9606.ENSP000001988012-acylglycerol O-acyltransferase 2; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty a [...]
AQP2 protein networkhttps://string-db.org/network/9606.ENSP00000199280Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an os [...]
DIMT1 protein networkhttps://string-db.org/network/9606.ENSP00000199320Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-r [...]
EIF2AK1 protein networkhttps://string-db.org/network/9606.ENSP00000199389Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, he [...]
NME8 protein networkhttps://string-db.org/network/9606.ENSP00000199447Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (F [...]
EPDR1 protein networkhttps://string-db.org/network/9606.ENSP00000199448Mammalian ependymin-related protein 1; Binds anionic lipids and gangliosides at acidic pH. Belongs to the ependymin family.
HBQ1 protein networkhttps://string-db.org/network/9606.ENSP00000199708Hemoglobin subunit theta 1.
CEACAM6 protein networkhttps://string-db.org/network/9606.ENSP00000199764Carcinoembryonic antigen-related cell adhesion molecule 6; Cell surface glycoprotein that plays a role in cell adhesion and tumor progression. Intercellular adhesion occurs in a calcium- and fibr [...]
RBM22 protein networkhttps://string-db.org/network/9606.ENSP00000199814Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem- loo [...]
HSD17B2 protein networkhttps://string-db.org/network/9606.ENSP00000199936Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha- HSD activity. Uses NADH whil [...]
ZW10 protein networkhttps://string-db.org/network/9606.ENSP00000200135Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin [...]
ITGB4 protein networkhttps://string-db.org/network/9606.ENSP00000200181Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polar [...]
PPP1R15A protein networkhttps://string-db.org/network/9606.ENSP00000200453Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut- [...]
TRIP6 protein networkhttps://string-db.org/network/9606.ENSP00000200457Thyroid receptor-interacting protein 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involv [...]
ADAM11 protein networkhttps://string-db.org/network/9606.ENSP00000200557Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.
SLC22A4 protein networkhttps://string-db.org/network/9606.ENSP00000200652Solute carrier family 22 member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations suc [...]
CETP protein networkhttps://string-db.org/network/9606.ENSP00000200676Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl e [...]
MT3 protein networkhttps://string-db.org/network/9606.ENSP00000200691Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortica [...]
TFAP2C protein networkhttps://string-db.org/network/9606.ENSP00000201031Transcription factor AP-2 gamma; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...]
SULT2B1 protein networkhttps://string-db.org/network/9606.ENSP00000201586Sulfotransferase 2B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Ca [...]
EPS8L1 protein networkhttps://string-db.org/network/9606.ENSP00000201647Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. Be [...]
REM1 protein networkhttps://string-db.org/network/9606.ENSP00000201979GTP-binding protein REM 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.
PDRG1 protein networkhttps://string-db.org/network/9606.ENSP00000202017P53 and DNA damage-regulated protein 1; May play a role in chaperone-mediated protein folding.
PPP1R13B protein networkhttps://string-db.org/network/9606.ENSP00000202556Apoptosis-stimulating of p53 protein 1; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transacti [...]
TGM6 protein networkhttps://string-db.org/network/9606.ENSP00000202625Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase [...]
RALGAPA2 protein networkhttps://string-db.org/network/9606.ENSP00000202677Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
ESF1 protein networkhttps://string-db.org/network/9606.ENSP00000202816ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity).
SIRT4 protein networkhttps://string-db.org/network/9606.ENSP00000202967NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and b [...]
TRMT6 protein networkhttps://string-db.org/network/9606.ENSP00000203001tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)-methyladenine at [...]
UQCRC1 protein networkhttps://string-db.org/network/9606.ENSP00000203407Cytochrome b-c1 complex subunit 1, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport [...]
GMIP protein networkhttps://string-db.org/network/9606.ENSP00000203556GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA.
LAG3 protein networkhttps://string-db.org/network/9606.ENSP00000203629Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as [...]
MLF2 protein networkhttps://string-db.org/network/9606.ENSP00000203630Myeloid leukemia factor 2.
OTUB2 protein networkhttps://string-db.org/network/9606.ENSP00000203664Ubiquitin thioesterase OTUB2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by prevent [...]
TFAP4 protein networkhttps://string-db.org/network/9606.ENSP00000204517Transcription factor AP-4; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
PDCD7 protein networkhttps://string-db.org/network/9606.ENSP00000204549Programmed cell death protein 7; Promotes apoptosis when overexpressed.
SPG21 protein networkhttps://string-db.org/network/9606.ENSP00000204566Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation.
CHRD protein networkhttps://string-db.org/network/9606.ENSP00000204604Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequest [...]
GNPTG protein networkhttps://string-db.org/network/9606.ENSP00000204679N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phospha [...]
GOLGA3 protein networkhttps://string-db.org/network/9606.ENSP00000204726Golgin subfamily A member 3; Golgi auto-antigen; probably involved in maintaining Golgi structure.
EFNB1 protein networkhttps://string-db.org/network/9606.ENSP00000204961Ephrin-B1 intracellular domain; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, [...]
GLG1 protein networkhttps://string-db.org/network/9606.ENSP00000205061Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).
DLL3 protein networkhttps://string-db.org/network/9606.ENSP00000205143Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmenta [...]
NAT14 protein networkhttps://string-db.org/network/9606.ENSP00000205194N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.
AASDH protein networkhttps://string-db.org/network/9606.ENSP00000205214Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown accepto [...]
DLD protein networkhttps://string-db.org/network/9606.ENSP00000205402Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruv [...]
ABCC6 protein networkhttps://string-db.org/network/9606.ENSP00000205557Multidrug resistance-associated protein 6; [Isoform 1]: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports [...]
CMTM6 protein networkhttps://string-db.org/network/9606.ENSP00000205636CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance [...]
APOH protein networkhttps://string-db.org/network/9606.ENSP00000205948Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation casca [...]
SPAG7 protein networkhttps://string-db.org/network/9606.ENSP00000206020Sperm associated antigen 7.
RGS17 protein networkhttps://string-db.org/network/9606.ENSP00000206262Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits [...]
CCDC80 protein networkhttps://string-db.org/network/9606.ENSP00000206423Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly.
HAUS4 protein networkhttps://string-db.org/network/9606.ENSP00000206474HAUS augmin-like complex subunit 4; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
CEBPE protein networkhttps://string-db.org/network/9606.ENSP00000206513CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA- binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhance [...]
OSGEP protein networkhttps://string-db.org/network/9606.ENSP00000206542Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) i [...]
G2E3 protein networkhttps://string-db.org/network/9606.ENSP00000206595G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers [...]
TGM1 protein networkhttps://string-db.org/network/9606.ENSP00000206765Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during forma [...]
TEKT2 protein networkhttps://string-db.org/network/9606.ENSP00000207457Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. [...]
UNC13D protein networkhttps://string-db.org/network/9606.ENSP00000207549Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates a [...]
XYLB protein networkhttps://string-db.org/network/9606.ENSP00000207870Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.
ADH1A protein networkhttps://string-db.org/network/9606.ENSP00000209668Alcohol dehydrogenase 1A, alpha polypeptide; Belongs to the zinc-containing alcohol dehydrogenase family.
KRT23 protein networkhttps://string-db.org/network/9606.ENSP00000209718Keratin, type I cytoskeletal 23; Keratin 23.
CDC6 protein networkhttps://string-db.org/network/9606.ENSP00000209728Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiat [...]
AAAS protein networkhttps://string-db.org/network/9606.ENSP00000209873Aladin; Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding pro [...]
CBX5 protein networkhttps://string-db.org/network/9606.ENSP00000209875Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded [...]
KLHL20 protein networkhttps://string-db.org/network/9606.ENSP00000209884Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR [...]
FMO2 protein networkhttps://string-db.org/network/9606.ENSP00000209929Dimethylaniline monooxygenase [N-oxide-forming] 2; Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary a [...]
DHPS protein networkhttps://string-db.org/network/9606.ENSP00000210060Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical ly [...]
RAB26 protein networkhttps://string-db.org/network/9606.ENSP00000210187Ras-related protein Rab-26; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
PSMD5 protein networkhttps://string-db.org/network/9606.ENSP0000021031326S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the [...]
NANS protein networkhttps://string-db.org/network/9606.ENSP00000210444Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate a [...]
SEMA4G protein networkhttps://string-db.org/network/9606.ENSP00000210633Semaphorin-4G; Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).
TPSD1 protein networkhttps://string-db.org/network/9606.ENSP00000211076Tryptase delta; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 fami [...]
GSTA3 protein networkhttps://string-db.org/network/9606.ENSP00000211122Glutathione S-transferase A3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the b [...]
MAPK13 protein networkhttps://string-db.org/network/9606.ENSP00000211287Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an [...]
TMEM14A protein networkhttps://string-db.org/network/9606.ENSP00000211314Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family.
PRRT1 protein networkhttps://string-db.org/network/9606.ENSP00000211413Proline rich transmembrane protein 1.
ZNF184 protein networkhttps://string-db.org/network/9606.ENSP00000211936Zinc finger protein 184; May be involved in transcriptional regulation.
VCL protein networkhttps://string-db.org/network/9606.ENSP00000211998Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E- [...]
SIRT1 protein networkhttps://string-db.org/network/9606.ENSP00000212015NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of s [...]
TGFBR3 protein networkhttps://string-db.org/network/9606.ENSP00000212355Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
TMED1 protein networkhttps://string-db.org/network/9606.ENSP00000214869Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorp [...]
MZF1 protein networkhttps://string-db.org/network/9606.ENSP00000215057Myeloid zinc finger 1; Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional eve [...]
OCEL1 protein networkhttps://string-db.org/network/9606.ENSP00000215061occludin/ELL domain containing 1; Belongs to the ELL/occludin family.
PSMD8 protein networkhttps://string-db.org/network/9606.ENSP0000021507126S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
STX1B protein networkhttps://string-db.org/network/9606.ENSP00000215095Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity).
EFNA2 protein networkhttps://string-db.org/network/9606.ENSP00000215368Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...]
ATP5F1D protein networkhttps://string-db.org/network/9606.ENSP00000215375ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...]
FGF22 protein networkhttps://string-db.org/network/9606.ENSP00000215530Fibroblast growth factor 22; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development [...]
SMIM24 protein networkhttps://string-db.org/network/9606.ENSP00000215531Small integral membrane protein 24.
NDUFB7 protein networkhttps://string-db.org/network/9606.ENSP00000215565NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
TECR protein networkhttps://string-db.org/network/9606.ENSP00000215567Very-long-chain enoyl-CoA reductase; Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids throu [...]
TIMM13 protein networkhttps://string-db.org/network/9606.ENSP00000215570Mitochondrial import inner membrane translocase subunit Tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into t [...]
CDC34 protein networkhttps://string-db.org/network/9606.ENSP00000215574Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperat [...]
MISP protein networkhttps://string-db.org/network/9606.ENSP00000215582Mitotic interactor and substrate of PLK1; Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner [...]
GADD45B protein networkhttps://string-db.org/network/9606.ENSP00000215631Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
MADCAM1 protein networkhttps://string-db.org/network/9606.ENSP00000215637Mucosal addressin cell adhesion molecule 1; Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and [...]
MAPK12 protein networkhttps://string-db.org/network/9606.ENSP00000215659Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an [...]
SERPIND1 protein networkhttps://string-db.org/network/9606.ENSP00000215727Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place o [...]
SNAP29 protein networkhttps://string-db.org/network/9606.ENSP00000215730Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on op [...]
THAP7 protein networkhttps://string-db.org/network/9606.ENSP00000215742THAP domain-containing protein 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.
MMP11 protein networkhttps://string-db.org/network/9606.ENSP00000215743Stromelysin-3; May play an important role in the progression of epithelial malignancies.
MIF protein networkhttps://string-db.org/network/9606.ENSP00000215754Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as [...]
DDTL protein networkhttps://string-db.org/network/9606.ENSP00000215770D-dopachrome decarboxylase-like protein; May have lyase activity; Belongs to the MIF family.
OSM protein networkhttps://string-db.org/network/9606.ENSP00000215781Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and [...]
SF3A1 protein networkhttps://string-db.org/network/9606.ENSP00000215793Splicing factor 3A subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of [...]
USP18 protein networkhttps://string-db.org/network/9606.ENSP00000215794Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked vi [...]
SEC14L3 protein networkhttps://string-db.org/network/9606.ENSP00000215812SEC14-like protein 3; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
SNRPD3 protein networkhttps://string-db.org/network/9606.ENSP00000215829Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, [...]
MAPK1 protein networkhttps://string-db.org/network/9606.ENSP00000215832Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which pla [...]
TCN2 protein networkhttps://string-db.org/network/9606.ENSP00000215838Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells; Belongs to the eukaryotic cobalamin transport proteins family.
CRYBB3 protein networkhttps://string-db.org/network/9606.ENSP00000215855Beta-crystallin B3, N-terminally processed; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
SLC25A1 protein networkhttps://string-db.org/network/9606.ENSP00000215882Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for iso [...]
PLA2G3 protein networkhttps://string-db.org/network/9606.ENSP00000215885Group 3 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosph [...]
LGALS2 protein networkhttps://string-db.org/network/9606.ENSP00000215886Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known.
PDXP protein networkhttps://string-db.org/network/9606.ENSP00000215904Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependen [...]
ASPHD2 protein networkhttps://string-db.org/network/9606.ENSP00000215906Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase.
LGALS1 protein networkhttps://string-db.org/network/9606.ENSP00000215909Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein [...]
PIK3IP1 protein networkhttps://string-db.org/network/9606.ENSP00000215912Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.
SRRD protein networkhttps://string-db.org/network/9606.ENSP00000215917SRR1-like protein; Plays a role in the regulation of heme biosynthesis and in the regulation of the expression of core clock genes.
ANKRD54 protein networkhttps://string-db.org/network/9606.ENSP00000215941Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
MICALL1 protein networkhttps://string-db.org/network/9606.ENSP00000215957MICAL-like protein 1; Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream e [...]
CENPM protein networkhttps://string-db.org/network/9606.ENSP00000215980Centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
DMC1 protein networkhttps://string-db.org/network/9606.ENSP00000216024Meiotic recombination protein DMC1/LIM15 homolog; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double- [...]
HSCB protein networkhttps://string-db.org/network/9606.ENSP00000216027Iron-sulfur cluster co-chaperone protein HscB, mitochondrial; Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sul [...]
TOMM22 protein networkhttps://string-db.org/network/9606.ENSP00000216034Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and transloc [...]
RSPH14 protein networkhttps://string-db.org/network/9606.ENSP00000216036Radial spoke head 14 homolog; Belongs to the flagellar radial spoke RSP14 family.
XBP1 protein networkhttps://string-db.org/network/9606.ENSP00000216037X-box-binding protein 1, cytoplasmic form; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myo [...]
RTCB protein networkhttps://string-db.org/network/9606.ENSP00000216038RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-deri [...]
JOSD1 protein networkhttps://string-db.org/network/9606.ENSP00000216039Josephin-1; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly- ubiquitin chains (in vitro), hence may act as a deubiquitina [...]
GTPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000216044GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).
DNAL4 protein networkhttps://string-db.org/network/9606.ENSP00000216068Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity).
C22orf31 protein networkhttps://string-db.org/network/9606.ENSP00000216071Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31.
MIOX protein networkhttps://string-db.org/network/9606.ENSP00000216075Myo-inositol oxygenase.
RHBDD3 protein networkhttps://string-db.org/network/9606.ENSP00000216085Rhomboid domain containing 3.
APOBEC3D protein networkhttps://string-db.org/network/9606.ENSP00000216099DNA dC->dU-editing enzyme APOBEC-3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
RASL10A protein networkhttps://string-db.org/network/9606.ENSP00000216101Ras-like protein family member 10A; Potent inhibitor of cellular proliferation.
HMGXB4 protein networkhttps://string-db.org/network/9606.ENSP00000216106HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development.
BIK protein networkhttps://string-db.org/network/9606.ENSP00000216115Bcl-2-interacting killer; Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoti [...]
HMOX1 protein networkhttps://string-db.org/network/9606.ENSP00000216117Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiologic [...]
NIPSNAP1 protein networkhttps://string-db.org/network/9606.ENSP00000216121Nipsnap homolog 1.
MCM5 protein networkhttps://string-db.org/network/9606.ENSP00000216122DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
ARSA protein networkhttps://string-db.org/network/9606.ENSP00000216124Arylsulfatase A component B; Hydrolyzes cerebroside sulfate.
RASD2 protein networkhttps://string-db.org/network/9606.ENSP00000216127GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, G [...]
TTLL12 protein networkhttps://string-db.org/network/9606.ENSP00000216129Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. [...]
CBX7 protein networkhttps://string-db.org/network/9606.ENSP00000216133Chromobox protein homolog 7; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
ACR protein networkhttps://string-db.org/network/9606.ENSP00000216139Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stor [...]
CABP7 protein networkhttps://string-db.org/network/9606.ENSP00000216144Calcium-binding protein 7; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
TAB1 protein networkhttps://string-db.org/network/9606.ENSP00000216160TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
PNPLA5 protein networkhttps://string-db.org/network/9606.ENSP00000216177Patatin-like phospholipase domain-containing protein 5; Lipid hydrolase.
PNPLA3 protein networkhttps://string-db.org/network/9606.ENSP000002161801-acylglycerol-3-phosphate O-acyltransferase PNPLA3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosph [...]
MYH9 protein networkhttps://string-db.org/network/9606.ENSP00000216181Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytosk [...]
TXN2 protein networkhttps://string-db.org/network/9606.ENSP00000216185Thioredoxin, mitochondrial; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity; Belongs [...]
EIF3D protein networkhttps://string-db.org/network/9606.ENSP00000216190Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the ini [...]
PVALB protein networkhttps://string-db.org/network/9606.ENSP00000216200Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family.
UPK3A protein networkhttps://string-db.org/network/9606.ENSP00000216211Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoske [...]
FAM118A protein networkhttps://string-db.org/network/9606.ENSP00000216214Protein FAM118A; Family with sequence similarity 118 member A.
ST13 protein networkhttps://string-db.org/network/9606.ENSP00000216218Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that h [...]
IL2RB protein networkhttps://string-db.org/network/9606.ENSP00000216223Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Probably in associatio [...]
RBX1 protein networkhttps://string-db.org/network/9606.ENSP00000216225E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination [...]
L3MBTL2 protein networkhttps://string-db.org/network/9606.ENSP00000216237Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...]
CHADL protein networkhttps://string-db.org/network/9606.ENSP00000216241Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its [...]
PHF5A protein networkhttps://string-db.org/network/9606.ENSP00000216252PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryo [...]
ACO2 protein networkhttps://string-db.org/network/9606.ENSP00000216254Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.
PMM1 protein networkhttps://string-db.org/network/9606.ENSP00000216259Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible f [...]
CERK protein networkhttps://string-db.org/network/9606.ENSP00000216264Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydrocerami [...]
ZBED4 protein networkhttps://string-db.org/network/9606.ENSP00000216268Zinc finger BED-type containing 4.
HDAC10 protein networkhttps://string-db.org/network/9606.ENSP00000216271Polyamine deacetylase HDAC10; Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic ac [...]
RIPK3 protein networkhttps://string-db.org/network/9606.ENSP00000216274Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necros [...]
PAPOLA protein networkhttps://string-db.org/network/9606.ENSP00000216277Poly(A) polymerase alpha; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity [...]
NID2 protein networkhttps://string-db.org/network/9606.ENSP00000216286Nidogen-2; Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role [...]
SNAPC1 protein networkhttps://string-db.org/network/9606.ENSP00000216294snRNA-activating protein complex subunit 1; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...]
SUPT16H protein networkhttps://string-db.org/network/9606.ENSP00000216297FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a [...]
FKBP3 protein networkhttps://string-db.org/network/9606.ENSP00000216330Peptidyl-prolyl cis-trans isomerase FKBP3; FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arre [...]
CTSG protein networkhttps://string-db.org/network/9606.ENSP00000216336Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial act [...]
GZMH protein networkhttps://string-db.org/network/9606.ENSP00000216338Granzyme H; Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for tar [...]
GZMB protein networkhttps://string-db.org/network/9606.ENSP00000216341Granzyme B; This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cy [...]
COCH protein networkhttps://string-db.org/network/9606.ENSP00000216361Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork.
AP4S1 protein networkhttps://string-db.org/network/9606.ENSP00000216366AP-4 complex subunit sigma-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They [...]
POLE2 protein networkhttps://string-db.org/network/9606.ENSP00000216367DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
SOS2 protein networkhttps://string-db.org/network/9606.ENSP00000216373Son of sevenless homolog 2; Promotes the exchange of Ras-bound GDP by GTP.
PYGL protein networkhttps://string-db.org/network/9606.ENSP00000216392Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their n [...]
GNPNAT1 protein networkhttps://string-db.org/network/9606.ENSP00000216410Glucosamine-phosphate N-acetyltransferase 1; Belongs to the acetyltransferase family. GNA1 subfamily.
CNIH1 protein networkhttps://string-db.org/network/9606.ENSP00000216416Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF- alpha family proteins; Belongs to the cornichon family.
CGRRF1 protein networkhttps://string-db.org/network/9606.ENSP00000216420Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines.
ATP6V1D protein networkhttps://string-db.org/network/9606.ENSP00000216442V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, [...]
PLEK2 protein networkhttps://string-db.org/network/9606.ENSP00000216446Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
PIGH protein networkhttps://string-db.org/network/9606.ENSP00000216452Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...]
PSMA3 protein networkhttps://string-db.org/network/9606.ENSP00000216455Proteasome subunit alpha type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
TMED8 protein networkhttps://string-db.org/network/9606.ENSP00000216468Protein TMED8; Transmembrane p24 trafficking protein family member 8.
SAMD15 protein networkhttps://string-db.org/network/9606.ENSP00000216471Sterile alpha motif domain containing 15.
AHSA1 protein networkhttps://string-db.org/network/9606.ENSP00000216479Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with [...]
SPTLC2 protein networkhttps://string-db.org/network/9606.ENSP00000216484Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) [...]
RIN3 protein networkhttps://string-db.org/network/9606.ENSP00000216487Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; [...]
ALKBH1 protein networkhttps://string-db.org/network/9606.ENSP00000216489Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been describ [...]
CHGA protein networkhttps://string-db.org/network/9606.ENSP00000216492p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the tr [...]
DHRS7 protein networkhttps://string-db.org/network/9606.ENSP00000216500Dehydrogenase/reductase SDR family member 7; Dehydrogenase/reductase 7.
SIX4 protein networkhttps://string-db.org/network/9606.ENSP00000216513Homeobox protein SIX4; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like [...]
SLC10A1 protein networkhttps://string-db.org/network/9606.ENSP00000216540Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly depe [...]
EIF5 protein networkhttps://string-db.org/network/9606.ENSP00000216554Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S rib [...]
ZFYVE21 protein networkhttps://string-db.org/network/9606.ENSP00000216602Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtub [...]
BDKRB1 protein networkhttps://string-db.org/network/9606.ENSP00000216629B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
VRK1 protein networkhttps://string-db.org/network/9606.ENSP00000216639Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragm [...]
APEX1 protein networkhttps://string-db.org/network/9606.ENSP00000216714DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA [...]
PABPN1 protein networkhttps://string-db.org/network/9606.ENSP00000216727Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). [...]
EFS protein networkhttps://string-db.org/network/9606.ENSP00000216733Embryonal Fyn-associated substrate; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a do [...]
CINP protein networkhttps://string-db.org/network/9606.ENSP00000216756Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 [...]
PCK2 protein networkhttps://string-db.org/network/9606.ENSP00000216780Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces [...]
NFKBIA protein networkhttps://string-db.org/network/9606.ENSP00000216797NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular st [...]
PSME2 protein networkhttps://string-db.org/network/9606.ENSP00000216802Proteasome activator complex subunit 2; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I bindin [...]
BRMS1L protein networkhttps://string-db.org/network/9606.ENSP00000216807Breast cancer metastasis-suppressor 1-like protein; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lac [...]
PNN protein networkhttps://string-db.org/network/9606.ENSP00000216832Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription [...]
CYP24A1 protein networkhttps://string-db.org/network/9606.ENSP000002168621,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24- and C23-oxidation pathways, cat [...]
AURKA protein networkhttps://string-db.org/network/9606.ENSP00000216911Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays [...]
ZFP64 protein networkhttps://string-db.org/network/9606.ENSP00000216923Zinc finger protein 64; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PYGB protein networkhttps://string-db.org/network/9606.ENSP00000216962Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different [...]
PROCR protein networkhttps://string-db.org/network/9606.ENSP00000216968Endothelial protein C receptor; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulatio [...]
MYBL2 protein networkhttps://string-db.org/network/9606.ENSP00000217026Myb-related protein B; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
R3HDML protein networkhttps://string-db.org/network/9606.ENSP00000217043Peptidase inhibitor R3HDML; Putative serine protease inhibitor; Belongs to the CRISP family.
SALL4 protein networkhttps://string-db.org/network/9606.ENSP00000217086Sal-like protein 4; Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
CSTF1 protein networkhttps://string-db.org/network/9606.ENSP00000217109Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with oth [...]
TPD52L2 protein networkhttps://string-db.org/network/9606.ENSP00000217121Tumor protein D54; TPD52 like 2.
CTSZ protein networkhttps://string-db.org/network/9606.ENSP00000217131Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides (By similarity); Belongs to the peptidase C1 family.
TUBB1 protein networkhttps://string-db.org/network/9606.ENSP00000217133Tubulin beta-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...]
SLCO4A1 protein networkhttps://string-db.org/network/9606.ENSP00000217159Solute carrier organic anion transporter family member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT [...]
BIRC7 protein networkhttps://string-db.org/network/9606.ENSP00000217169Baculoviral IAP repeat-containing protein 7 30kDa subunit; Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferat [...]
UBOX5 protein networkhttps://string-db.org/network/9606.ENSP00000217173RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substr [...]
EEF1A2 protein networkhttps://string-db.org/network/9606.ENSP00000217182Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation fac [...]
SRMS protein networkhttps://string-db.org/network/9606.ENSP00000217188Tyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation [...]
C20orf27 protein networkhttps://string-db.org/network/9606.ENSP00000217195UPF0687 protein C20orf27; Chromosome 20 open reading frame 27.
CSNK2A1 protein networkhttps://string-db.org/network/9606.ENSP00000217244Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C- [...]
MACROD2 protein networkhttps://string-db.org/network/9606.ENSP00000217246ADP-ribose glycohydrolase MACROD2; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Dea [...]
RSPO4 protein networkhttps://string-db.org/network/9606.ENSP00000217260R-spondin-4; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...]
PROKR2 protein networkhttps://string-db.org/network/9606.ENSP00000217270Prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinosit [...]
FERMT1 protein networkhttps://string-db.org/network/9606.ENSP00000217289Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte prolifera [...]
TLDC2 protein networkhttps://string-db.org/network/9606.ENSP00000217320TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family.
CDK5RAP1 protein networkhttps://string-db.org/network/9606.ENSP00000217372CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1; Belongs to the methylthiotransferase family. MiaB subfamily.
SNTA1 protein networkhttps://string-db.org/network/9606.ENSP00000217381Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and t [...]
OXT protein networkhttps://string-db.org/network/9606.ENSP00000217386Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin.
CHMP4B protein networkhttps://string-db.org/network/9606.ENSP00000217402Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
LBP protein networkhttps://string-db.org/network/9606.ENSP00000217407Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of a [...]
SLC32A1 protein networkhttps://string-db.org/network/9606.ENSP00000217420Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles.
CST4 protein networkhttps://string-db.org/network/9606.ENSP00000217423Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited [...]
AHCY protein networkhttps://string-db.org/network/9606.ENSP00000217426Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in [...]
SPINT3 protein networkhttps://string-db.org/network/9606.ENSP00000217428Serine peptidase inhibitor, Kunitz type 3.
PIGU protein networkhttps://string-db.org/network/9606.ENSP00000217446Phosphatidylinositol glycan anchor biosynthesis class U protein; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid por [...]
ACOT8 protein networkhttps://string-db.org/network/9606.ENSP00000217455Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing [...]
APMAP protein networkhttps://string-db.org/network/9606.ENSP00000217456Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the str [...]
TXNL1 protein networkhttps://string-db.org/network/9606.ENSP00000217515Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV.
RNF125 protein networkhttps://string-db.org/network/9606.ENSP00000217740E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, [...]
IDH3G protein networkhttps://string-db.org/network/9606.ENSP00000217901Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) in [...]
SLC25A43 protein networkhttps://string-db.org/network/9606.ENSP00000217909Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family.
MXRA5 protein networkhttps://string-db.org/network/9606.ENSP00000217939Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to T [...]
PSMD10 protein networkhttps://string-db.org/network/9606.ENSP0000021795826S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the b [...]
STS protein networkhttps://string-db.org/network/9606.ENSP00000217961Steryl-sulfatase; Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
PGRMC1 protein networkhttps://string-db.org/network/9606.ENSP00000217971Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction [...]
RHOXF1 protein networkhttps://string-db.org/network/9606.ENSP00000217999Rhox homeobox family member 1; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogene [...]
NXT2 protein networkhttps://string-db.org/network/9606.ENSP00000218004NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
GUCY2F protein networkhttps://string-db.org/network/9606.ENSP00000218006Retinal guanylyl cyclase 2; Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment ( [...]
ATP1B4 protein networkhttps://string-db.org/network/9606.ENSP00000218008Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the [...]
PAGE4 protein networkhttps://string-db.org/network/9606.ENSP00000218068P antigen family member 4; Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxy [...]
GLRA2 protein networkhttps://string-db.org/network/9606.ENSP00000218075Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and bet [...]
STAG2 protein networkhttps://string-db.org/network/9606.ENSP00000218089Cohesin subunit SA-2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring [...]
F9 protein networkhttps://string-db.org/network/9606.ENSP00000218099Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in [...]
ABCD1 protein networkhttps://string-db.org/network/9606.ENSP00000218104ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an [...]
KCND1 protein networkhttps://string-db.org/network/9606.ENSP00000218176Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I( [...]
PCSK1N protein networkhttps://string-db.org/network/9606.ENSP00000218230Big PEN-LEN; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inh [...]
RAB40AL protein networkhttps://string-db.org/network/9606.ENSP00000218249Ras-related protein Rab-40A-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and su [...]
GPR50 protein networkhttps://string-db.org/network/9606.ENSP00000218316Melatonin-related receptor; Does not bind melatonin.
RP2 protein networkhttps://string-db.org/network/9606.ENSP00000218340Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium memb [...]
USP11 protein networkhttps://string-db.org/network/9606.ENSP00000218348Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasom [...]
TIMP1 protein networkhttps://string-db.org/network/9606.ENSP00000218388Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them b [...]
ITIH6 protein networkhttps://string-db.org/network/9606.ENSP00000218436Inter-alpha-trypsin inhibitor heavy chain family member 6.
GLA protein networkhttps://string-db.org/network/9606.ENSP00000218516Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family.
ATP12A protein networkhttps://string-db.org/network/9606.ENSP00000218548Potassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in va [...]
MLNR protein networkhttps://string-db.org/network/9606.ENSP00000218721Motilin receptor; Receptor for motilin; Belongs to the G-protein coupled receptor 1 family.
ACP5 protein networkhttps://string-db.org/network/9606.ENSP00000218758Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgki [...]
SGCG protein networkhttps://string-db.org/network/9606.ENSP00000218867Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
OLFM4 protein networkhttps://string-db.org/network/9606.ENSP00000219022Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell dif [...]
NTHL1 protein networkhttps://string-db.org/network/9606.ENSP00000219066Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary [...]
ZNF263 protein networkhttps://string-db.org/network/9606.ENSP00000219069Zinc finger protein 263; Might play an important role in basic cellular processes as a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family.
MMP2 protein networkhttps://string-db.org/network/9606.ENSP0000021907072 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, [...]
ORC6 protein networkhttps://string-db.org/network/9606.ENSP00000219097Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...]
C16orf70 protein networkhttps://string-db.org/network/9606.ENSP00000219139UPF0183 protein C16orf70; Chromosome 16 open reading frame 70; Belongs to the UPF0183 family.
CORO1A protein networkhttps://string-db.org/network/9606.ENSP00000219150Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of th [...]
MT4 protein networkhttps://string-db.org/network/9606.ENSP00000219162Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
NUTF2 protein networkhttps://string-db.org/network/9606.ENSP00000219169Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transp [...]
CBLN1 protein networkhttps://string-db.org/network/9606.ENSP00000219197[des-Ser1]-cerebellin; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements a [...]
ARL2BP protein networkhttps://string-db.org/network/9606.ENSP00000219204ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effec [...]
PLLP protein networkhttps://string-db.org/network/9606.ENSP00000219207Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are vo [...]
CCL22 protein networkhttps://string-db.org/network/9606.ENSP00000219235C-C motif chemokine 22; May play a role in the trafficking of activated/effector T- lymphocytes to inflammatory sites and other aspects of activated T- lymphocyte physiology. Chemotactic for mono [...]
DHODH protein networkhttps://string-db.org/network/9606.ENSP00000219240Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
CCL17 protein networkhttps://string-db.org/network/9606.ENSP00000219244C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells [...]
POLR2C protein networkhttps://string-db.org/network/9606.ENSP00000219252DNA-directed RNA polymerase II subunit RPB3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
PARD6A protein networkhttps://string-db.org/network/9606.ENSP00000219255Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. A [...]
MMP15 protein networkhttps://string-db.org/network/9606.ENSP00000219271Matrix metalloproteinase-15; Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family.
USB1 protein networkhttps://string-db.org/network/9606.ENSP00000219281U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides [...]
CCDC113 protein networkhttps://string-db.org/network/9606.ENSP00000219299Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation.
PRSS54 protein networkhttps://string-db.org/network/9606.ENSP00000219301Serine protease 54.
NME3 protein networkhttps://string-db.org/network/9606.ENSP00000219302Nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...]
PSMD7 protein networkhttps://string-db.org/network/9606.ENSP0000021931326S proteasome non-ATPase regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
SETD6 protein networkhttps://string-db.org/network/9606.ENSP00000219315N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor [...]
SMPD3 protein networkhttps://string-db.org/network/9606.ENSP00000219334Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arres [...]
PLA2G15 protein networkhttps://string-db.org/network/9606.ENSP00000219345Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso- phosp [...]
FA2H protein networkhttps://string-db.org/network/9606.ENSP00000219368Fatty acid 2-hydroxylase; Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids c [...]
CMC2 protein networkhttps://string-db.org/network/9606.ENSP00000219400COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family.
PDIA2 protein networkhttps://string-db.org/network/9606.ENSP00000219406Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as [...]
ARHGDIG protein networkhttps://string-db.org/network/9606.ENSP00000219409Rho GDP-dissociation inhibitor 3; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, bo [...]
MPG protein networkhttps://string-db.org/network/9606.ENSP00000219431DNA-3-methyladenine glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
HSDL1 protein networkhttps://string-db.org/network/9606.ENSP00000219439Inactive hydroxysteroid dehydrogenase-like protein 1; Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
TSC2 protein networkhttps://string-db.org/network/9606.ENSP00000219476Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Act [...]
ZNF500 protein networkhttps://string-db.org/network/9606.ENSP00000219478Zinc finger protein 500; May be involved in transcriptional regulation.
NME4 protein networkhttps://string-db.org/network/9606.ENSP00000219479Nucleoside diphosphate kinase, mitochondrial; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-p [...]
DECR2 protein networkhttps://string-db.org/network/9606.ENSP00000219481Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered [...]
STUB1 protein networkhttps://string-db.org/network/9606.ENSP00000219548E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded [...]
RHBDL1 protein networkhttps://string-db.org/network/9606.ENSP00000219551Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
MEFV protein networkhttps://string-db.org/network/9606.ENSP00000219596Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, [...]
CRYM protein networkhttps://string-db.org/network/9606.ENSP00000219599Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyro [...]
CAPN15 protein networkhttps://string-db.org/network/9606.ENSP00000219611Calpain-15; Calpain 15; Belongs to the peptidase C2 family.
AQP8 protein networkhttps://string-db.org/network/9606.ENSP00000219660Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family.
USP31 protein networkhttps://string-db.org/network/9606.ENSP00000219689Ubiquitin carboxyl-terminal hydrolase 31; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that [...]
TOX3 protein networkhttps://string-db.org/network/9606.ENSP00000219746TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Prote [...]
MAZ protein networkhttps://string-db.org/network/9606.ENSP00000219782Myc-associated zinc finger protein; May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promote [...]
CDIPT protein networkhttps://string-db.org/network/9606.ENSP00000219789CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessi [...]
SLC6A2 protein networkhttps://string-db.org/network/9606.ENSP00000219833Sodium-dependent noradrenaline transporter; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sod [...]
KNOP1 protein networkhttps://string-db.org/network/9606.ENSP00000219837Lysine rich nucleolar protein 1.
MGA protein networkhttps://string-db.org/network/9606.ENSP00000219905MAX gene-associated protein; Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an acti [...]
AQP9 protein networkhttps://string-db.org/network/9606.ENSP00000219919Aquaporin-9; Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, puri [...]
CSK protein networkhttps://string-db.org/network/9606.ENSP00000220003Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyr [...]
MTFMT protein networkhttps://string-db.org/network/9606.ENSP00000220058Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechani [...]
RASL12 protein networkhttps://string-db.org/network/9606.ENSP00000220062Ras-like protein family member 12; RAS like family 12.
CTSH protein networkhttps://string-db.org/network/9606.ENSP00000220166Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family.
EHD4 protein networkhttps://string-db.org/network/9606.ENSP00000220325EH domain-containing protein 4; ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
TGM5 protein networkhttps://string-db.org/network/9606.ENSP00000220420Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope o [...]
GABPB1 protein networkhttps://string-db.org/network/9606.ENSP00000220429GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By simil [...]
SCG3 protein networkhttps://string-db.org/network/9606.ENSP00000220478Secretogranin-3; Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By s [...]
DNAJC17 protein networkhttps://string-db.org/network/9606.ENSP00000220496DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription.
RHOV protein networkhttps://string-db.org/network/9606.ENSP00000220507Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family.
VPS18 protein networkhttps://string-db.org/network/9606.ENSP00000220509Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...]
OIP5 protein networkhttps://string-db.org/network/9606.ENSP00000220514Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family.
EXTL3 protein networkhttps://string-db.org/network/9606.ENSP00000220562Exostosin-like 3; Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycan [...]
AGO2 protein networkhttps://string-db.org/network/9606.ENSP00000220592Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a [...]
PAG1 protein networkhttps://string-db.org/network/9606.ENSP00000220597Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin [...]
TG protein networkhttps://string-db.org/network/9606.ENSP00000220616Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine r [...]
BRF2 protein networkhttps://string-db.org/network/9606.ENSP00000220659Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements u [...]
ZFAND1 protein networkhttps://string-db.org/network/9606.ENSP00000220669AN1-type zinc finger protein 1; Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for [...]
RP1 protein networkhttps://string-db.org/network/9606.ENSP00000220676Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photorecepto [...]
RIPK2 protein networkhttps://string-db.org/network/9606.ENSP00000220751Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by ba [...]
CPQ protein networkhttps://string-db.org/network/9606.ENSP00000220763Carboxypeptidase Q; Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acid [...]
DECR1 protein networkhttps://string-db.org/network/9606.ENSP000002207642,4-dienoyl-CoA reductase, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-num [...]
SFRP1 protein networkhttps://string-db.org/network/9606.ENSP00000220772Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...]
PLAT protein networkhttps://string-db.org/network/9606.ENSP00000220809Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated [...]
DKK4 protein networkhttps://string-db.org/network/9606.ENSP00000220812Dickkopf-related protein 4 short form; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that pr [...]
GDAP1 protein networkhttps://string-db.org/network/9606.ENSP00000220822Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission; Belongs to the GST superfamily.
EIF3E protein networkhttps://string-db.org/network/9606.ENSP00000220849Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
EMC2 protein networkhttps://string-db.org/network/9606.ENSP00000220853ER membrane protein complex subunit 2.
CHRAC1 protein networkhttps://string-db.org/network/9606.ENSP00000220913Chromatin accessibility complex protein 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remode [...]
GML protein networkhttps://string-db.org/network/9606.ENSP00000220940Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage.
PYCR3 protein networkhttps://string-db.org/network/9606.ENSP00000220966Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carb [...]
MTMR9 protein networkhttps://string-db.org/network/9606.ENSP00000221086Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5- bisp [...]
DCTN6 protein networkhttps://string-db.org/network/9606.ENSP00000221114Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
GSR protein networkhttps://string-db.org/network/9606.ENSP00000221130Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol.
TNFRSF10A protein networkhttps://string-db.org/network/9606.ENSP00000221132Tumor necrosis factor receptor superfamily member 10A; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death [...]
PPP2CB protein networkhttps://string-db.org/network/9606.ENSP00000221138Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. B [...]
NEFM protein networkhttps://string-db.org/network/9606.ENSP00000221166Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
KCTD9 protein networkhttps://string-db.org/network/9606.ENSP00000221200BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to [...]
EXOSC5 protein networkhttps://string-db.org/network/9606.ENSP00000221233Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
PAF1 protein networkhttps://string-db.org/network/9606.ENSP00000221265RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of deve [...]
CYP4F3 protein networkhttps://string-db.org/network/9606.ENSP00000221307Cytochrome P450 4F3; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistical [...]
ZNF432 protein networkhttps://string-db.org/network/9606.ENSP00000221315Zinc finger protein 432; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF180 protein networkhttps://string-db.org/network/9606.ENSP00000221327Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TULP2 protein networkhttps://string-db.org/network/9606.ENSP00000221399TUB like protein 2; Belongs to the TUB family.
DHDH protein networkhttps://string-db.org/network/9606.ENSP00000221403Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family.
ECH1 protein networkhttps://string-db.org/network/9606.ENSP00000221418Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA.
HNRNPL protein networkhttps://string-db.org/network/9606.ENSP00000221419Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for [...]
KCNA7 protein networkhttps://string-db.org/network/9606.ENSP00000221444Potassium voltage-gated channel subfamily A member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...]
RELB protein networkhttps://string-db.org/network/9606.ENSP00000221452Transcription factor RelB; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, [...]
CLASRP protein networkhttps://string-db.org/network/9606.ENSP00000221455CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the [...]
LIN7B protein networkhttps://string-db.org/network/9606.ENSP00000221459Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...]
PPP1R37 protein networkhttps://string-db.org/network/9606.ENSP00000221462Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
CKM protein networkhttps://string-db.org/network/9606.ENSP00000221476Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy tran [...]
PEX11G protein networkhttps://string-db.org/network/9606.ENSP00000221480Peroxisomal membrane protein 11C; Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family.
SLC17A7 protein networkhttps://string-db.org/network/9606.ENSP00000221485Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...]
RNASEH2A protein networkhttps://string-db.org/network/9606.ENSP00000221486Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the remova [...]
SF3A2 protein networkhttps://string-db.org/network/9606.ENSP00000221494Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of [...]
AMH protein networkhttps://string-db.org/network/9606.ENSP00000221496Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived fro [...]
DKKL1 protein networkhttps://string-db.org/network/9606.ENSP00000221498Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may r [...]
RETN protein networkhttps://string-db.org/network/9606.ENSP00000221515Resistin; Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis [...]
RSPH6A protein networkhttps://string-db.org/network/9606.ENSP00000221538Radial spoke head 6 homolog A; Belongs to the flagellar radial spoke RSP4/6 family.
TBC1D17 protein networkhttps://string-db.org/network/9606.ENSP00000221543TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transf [...]
TLE5 protein networkhttps://string-db.org/network/9606.ENSP00000221561TLE family member 5; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and ma [...]
SGTA protein networkhttps://string-db.org/network/9606.ENSP00000221566Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their target [...]
SNAPC2 protein networkhttps://string-db.org/network/9606.ENSP00000221573snRNA-activating protein complex subunit 2; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...]
FIZ1 protein networkhttps://string-db.org/network/9606.ENSP00000221665Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).
C19orf44 protein networkhttps://string-db.org/network/9606.ENSP00000221671Uncharacterized protein C19orf44; Chromosome 19 open reading frame 44.
CYP4F2 protein networkhttps://string-db.org/network/9606.ENSP00000221700Cytochrome P450 4F2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins. Mechanistically, uses molecular [...]
EPHX3 protein networkhttps://string-db.org/network/9606.ENSP00000221730Epoxide hydrolase 3; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9- EET, 9,10-EET, 11,12-EET and 14,15-EET and [...]
SLC1A6 protein networkhttps://string-db.org/network/9606.ENSP00000221742Excitatory amino acid transporter 4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...]
LGALS13 protein networkhttps://string-db.org/network/9606.ENSP00000221797Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.
FBL protein networkhttps://string-db.org/network/9606.ENSP00000221801rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzin [...]
CLC protein networkhttps://string-db.org/network/9606.ENSP00000221804Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).
EBI3 protein networkhttps://string-db.org/network/9606.ENSP00000221847Interleukin-27 subunit beta; Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that [...]
TBCB protein networkhttps://string-db.org/network/9606.ENSP00000221855Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded [...]
FSD1 protein networkhttps://string-db.org/network/9606.ENSP00000221856Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization.
POLR2I protein networkhttps://string-db.org/network/9606.ENSP00000221859DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
APLP1 protein networkhttps://string-db.org/network/9606.ENSP00000221891Amyloid-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By sim [...]
CCDC9 protein networkhttps://string-db.org/network/9606.ENSP00000221922Coiled-coil domain containing 9.
TGFB1 protein networkhttps://string-db.org/network/9606.ENSP00000221930Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) ch [...]
CEACAM4 protein networkhttps://string-db.org/network/9606.ENSP00000221954Carcinoembryonic antigen-related cell adhesion molecule 4; Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.
PLIN3 protein networkhttps://string-db.org/network/9606.ENSP00000221957Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network.
CD79A protein networkhttps://string-db.org/network/9606.ENSP00000221972B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell [...]
LIM2 protein networkhttps://string-db.org/network/9606.ENSP00000221973Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for cal [...]
NKG7 protein networkhttps://string-db.org/network/9606.ENSP00000221978Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family.
ICAM5 protein networkhttps://string-db.org/network/9606.ENSP00000221980Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
CEACAM5 protein networkhttps://string-db.org/network/9606.ENSP00000221992Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and het [...]
CRX protein networkhttps://string-db.org/network/9606.ENSP00000221996Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin gen [...]
SULT2A1 protein networkhttps://string-db.org/network/9606.ENSP00000222002Bile salt sulfotransferase; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal [...]
CDC37 protein networkhttps://string-db.org/network/9606.ENSP00000222005Hsp90 co-chaperone Cdc37, N-terminally processed; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of th [...]
RABAC1 protein networkhttps://string-db.org/network/9606.ENSP00000222008Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPas [...]
CNFN protein networkhttps://string-db.org/network/9606.ENSP00000222032Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family.
ZNRF4 protein networkhttps://string-db.org/network/9606.ENSP00000222033E3 ubiquitin-protein ligase ZNRF4; E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in [...]
HAS1 protein networkhttps://string-db.org/network/9606.ENSP00000222115Hyaluronan synthase 1; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...]
RAB3D protein networkhttps://string-db.org/network/9606.ENSP00000222120Ras-related protein Rab-3D; Protein transport. Probably involved in regulated exocytosis (By similarity); Belongs to the small GTPase superfamily. Rab family.
DBP protein networkhttps://string-db.org/network/9606.ENSP00000222122D site-binding protein; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential [...]
EPOR protein networkhttps://string-db.org/network/9606.ENSP00000222139Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT [...]
RASIP1 protein networkhttps://string-db.org/network/9606.ENSP00000222145Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GT [...]
DNASE2 protein networkhttps://string-db.org/network/9606.ENSP00000222219Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during deve [...]
LENG1 protein networkhttps://string-db.org/network/9606.ENSP00000222224Leukocyte receptor cluster member 1.
RPL18A protein networkhttps://string-db.org/network/9606.ENSP00000222247Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.
SLC5A5 protein networkhttps://string-db.org/network/9606.ENSP00000222248Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
ARRDC2 protein networkhttps://string-db.org/network/9606.ENSP00000222250Arrestin domain containing 2; Belongs to the arrestin family.
PIK3R2 protein networkhttps://string-db.org/network/9606.ENSP00000222254Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) [...]
RAB3A protein networkhttps://string-db.org/network/9606.ENSP00000222256Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the [...]
COMP protein networkhttps://string-db.org/network/9606.ENSP00000222271Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. C [...]
TMEM147 protein networkhttps://string-db.org/network/9606.ENSP00000222284Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobili [...]
GAPDHS protein networkhttps://string-db.org/network/9606.ENSP00000222286Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the sp [...]
USF2 protein networkhttps://string-db.org/network/9606.ENSP00000222305Upstream stimulatory factor 2; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
ERF protein networkhttps://string-db.org/network/9606.ENSP00000222329ETS domain-containing transcription factor ERF; Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Re [...]
GSK3A protein networkhttps://string-db.org/network/9606.ENSP00000222330Glycogen synthase kinase-3 alpha; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcript [...]
ZNF574 protein networkhttps://string-db.org/network/9606.ENSP00000222339Zinc finger protein 574; May be involved in transcriptional regulation.
SIPA1L3 protein networkhttps://string-db.org/network/9606.ENSP00000222345Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens.
CADM4 protein networkhttps://string-db.org/network/9606.ENSP00000222374Cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity.
PON1 protein networkhttps://string-db.org/network/9606.ENSP00000222381Serum paraoxonase/arylesterase 1; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactone [...]
CYP3A43 protein networkhttps://string-db.org/network/9606.ENSP00000222382Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Belongs to the cytochrome P450 family.
ABCF2 protein networkhttps://string-db.org/network/9606.ENSP00000222388ATP binding cassette subfamily F member 2.
HGF protein networkhttps://string-db.org/network/9606.ENSP00000222390Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and c [...]
LAMB1 protein networkhttps://string-db.org/network/9606.ENSP00000222399Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
UBE2D4 protein networkhttps://string-db.org/network/9606.ENSP00000222402Ubiquitin-conjugating enzyme E2 D4; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquiti [...]
WNT16 protein networkhttps://string-db.org/network/9606.ENSP00000222462Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...]
CPA2 protein networkhttps://string-db.org/network/9606.ENSP00000222481Carboxypeptidase A2.
CPA4 protein networkhttps://string-db.org/network/9606.ENSP00000222482Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val ; [...]
GTPBP10 protein networkhttps://string-db.org/network/9606.ENSP00000222511GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorg [...]
TFPI2 protein networkhttps://string-db.org/network/9606.ENSP00000222543Tissue factor pathway inhibitor 2; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effec [...]
BET1 protein networkhttps://string-db.org/network/9606.ENSP00000222547BET1 homolog; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER- derived vesicles with the cis-Golgi membrane (By simil [...]
NAMPT protein networkhttps://string-db.org/network/9606.ENSP00000222553Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis [...]
TWISTNB protein networkhttps://string-db.org/network/9606.ENSP00000222567DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
ITGB8 protein networkhttps://string-db.org/network/9606.ENSP00000222573Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-depende [...]
HBP1 protein networkhttps://string-db.org/network/9606.ENSP00000222574HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferent [...]
SP4 protein networkhttps://string-db.org/network/9606.ENSP00000222584Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
MPP6 protein networkhttps://string-db.org/network/9606.ENSP00000222644MAGUK p55 subfamily member 6; Membrane palmitoylated protein 6; Belongs to the MAGUK family.
NPVF protein networkhttps://string-db.org/network/9606.ENSP00000222674Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-i [...]
CAV2 protein networkhttps://string-db.org/network/9606.ENSP00000222693Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein [...]
HOXA2 protein networkhttps://string-db.org/network/9606.ENSP00000222718Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
LFNG protein networkhttps://string-db.org/network/9606.ENSP00000222725Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of [...]
HOXA5 protein networkhttps://string-db.org/network/9606.ENSP00000222726Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
HOXA6 protein networkhttps://string-db.org/network/9606.ENSP00000222728Homeobox protein Hox-A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
TSPAN12 protein networkhttps://string-db.org/network/9606.ENSP00000222747Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin [...]
CHN2 protein networkhttps://string-db.org/network/9606.ENSP00000222792Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression fr [...]
ABHD11 protein networkhttps://string-db.org/network/9606.ENSP00000222800Protein ABHD11; Abhydrolase domain containing 11.
FKBP14 protein networkhttps://string-db.org/network/9606.ENSP00000222803Peptidyl-prolyl cis-trans isomerase FKBP14; PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4- hydroxylproline modifications, [...]
STX1A protein networkhttps://string-db.org/network/9606.ENSP00000222812Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, [...]
NOD1 protein networkhttps://string-db.org/network/9606.ENSP00000222823Nucleotide-binding oligomerization domain-containing protein 1; Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular [...]
PDAP1 protein networkhttps://string-db.org/network/9606.ENSP0000022296828 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB.
CYP3A5 protein networkhttps://string-db.org/network/9606.ENSP00000222982Cytochrome P450 3A5; A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate [...]
SNX8 protein networkhttps://string-db.org/network/9606.ENSP00000222990Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.
WASL protein networkhttps://string-db.org/network/9606.ENSP00000223023Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cyt [...]
HYAL4 protein networkhttps://string-db.org/network/9606.ENSP00000223026Hyaluronidase-4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic l [...]
AIMP2 protein networkhttps://string-db.org/network/9606.ENSP00000223029Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1 [...]
PCOLCE protein networkhttps://string-db.org/network/9606.ENSP00000223061Procollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.
RBM28 protein networkhttps://string-db.org/network/9606.ENSP00000223073RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes.
SERPINE1 protein networkhttps://string-db.org/network/9606.ENSP00000223095Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). [...]
MOGAT3 protein networkhttps://string-db.org/network/9606.ENSP000002231142-acylglycerol O-acyltransferase 3; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by [...]
PLOD3 protein networkhttps://string-db.org/network/9606.ENSP00000223127Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procoll [...]
RPA3 protein networkhttps://string-db.org/network/9606.ENSP00000223129Replication protein A 14 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replicati [...]
FIS1 protein networkhttps://string-db.org/network/9606.ENSP00000223136Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission me [...]
GLCCI1 protein networkhttps://string-db.org/network/9606.ENSP00000223145Glucocorticoid-induced transcript 1 protein; Glucocorticoid induced 1.
MYL10 protein networkhttps://string-db.org/network/9606.ENSP00000223167Myosin light chain 10.
CEP41 protein networkhttps://string-db.org/network/9606.ENSP00000223208Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the b [...]
ZNF862 protein networkhttps://string-db.org/network/9606.ENSP00000223210Zinc finger protein 862; May be involved in transcriptional regulation.
MEST protein networkhttps://string-db.org/network/9606.ENSP00000223215Mesoderm-specific transcript homolog protein; Mesoderm specific transcript; Belongs to the AB hydrolase superfamily.
YAE1 protein networkhttps://string-db.org/network/9606.ENSP00000223273Protein YAE1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be r [...]
GIMAP2 protein networkhttps://string-db.org/network/9606.ENSP00000223293GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself.
PSMA2 protein networkhttps://string-db.org/network/9606.ENSP00000223321Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
MRPL32 protein networkhttps://string-db.org/network/9606.ENSP00000223324Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.
AEBP1 protein networkhttps://string-db.org/network/9606.ENSP00000223357Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Bel [...]
MYL7 protein networkhttps://string-db.org/network/9606.ENSP00000223364Myosin regulatory light chain 2, atrial isoform; Myosin light chain 7.
GCK protein networkhttps://string-db.org/network/9606.ENSP00000223366Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, [...]
YKT6 protein networkhttps://string-db.org/network/9606.ENSP00000223369Synaptobrevin homolog YKT6; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic [...]
CLIP2 protein networkhttps://string-db.org/network/9606.ENSP00000223398CAP-Gly domain-containing linker protein 2; Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons li [...]
ZNF688 protein networkhttps://string-db.org/network/9606.ENSP00000223459Zinc finger protein 688; May be involved in transcriptional regulation.
CHMP5 protein networkhttps://string-db.org/network/9606.ENSP00000223500Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodie [...]
FKTN protein networkhttps://string-db.org/network/9606.ENSP00000223528Fukutin; Catalyzes the transfer of CDP-ribitol to the distal N- acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosp [...]
SEC61B protein networkhttps://string-db.org/network/9606.ENSP00000223641Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic [...]
C5 protein networkhttps://string-db.org/network/9606.ENSP00000223642Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient [...]
TNFSF8 protein networkhttps://string-db.org/network/9606.ENSP00000223795Tumor necrosis factor ligand superfamily member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
AK1 protein networkhttps://string-db.org/network/9606.ENSP00000223836Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important [...]
RLN1 protein networkhttps://string-db.org/network/9606.ENSP00000223862Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnan [...]
PLGRKT protein networkhttps://string-db.org/network/9606.ENSP00000223864Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activ [...]
EDF1 protein networkhttps://string-db.org/network/9606.ENSP00000224073Endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand- dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activit [...]
SETX protein networkhttps://string-db.org/network/9606.ENSP00000224140Probable helicase senataxin; Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA [...]
BLNK protein networkhttps://string-db.org/network/9606.ENSP00000224337B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outc [...]
CYP26A1 protein networkhttps://string-db.org/network/9606.ENSP00000224356Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene t [...]
ATE1 protein networkhttps://string-db.org/network/9606.ENSP00000224652Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradatio [...]
CDH23 protein networkhttps://string-db.org/network/9606.ENSP00000224721Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing an [...]
ACTA2 protein networkhttps://string-db.org/network/9606.ENSP00000224784Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
SFXN3 protein networkhttps://string-db.org/network/9606.ENSP00000224807Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to [...]
FBXL15 protein networkhttps://string-db.org/network/9606.ENSP00000224862F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal de [...]
STN1 protein networkhttps://string-db.org/network/9606.ENSP00000224950CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...]
DNAJC12 protein networkhttps://string-db.org/network/9606.ENSP00000225171DnaJ heat shock protein family member C12.
PPIF protein networkhttps://string-db.org/network/9606.ENSP00000225174Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. [...]
TBC1D12 protein networkhttps://string-db.org/network/9606.ENSP00000225235TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth.
MPO protein networkhttps://string-db.org/network/9606.ENSP00000225275Myeloperoxidase heavy chain; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, [...]
ST6GALNAC2 protein networkhttps://string-db.org/network/9606.ENSP00000225276Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins.
DHX33 protein networkhttps://string-db.org/network/9606.ENSP00000225296ATP-dependent RNA helicase DHX33; Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity). Stimulates RNA polymerase I transcrip [...]
UTP18 protein networkhttps://string-db.org/network/9606.ENSP00000225298U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.
P2RX5 protein networkhttps://string-db.org/network/9606.ENSP00000225328P2X purinoceptor 5; Receptor for ATP that acts as a ligand-gated ion channel; Belongs to the P2X receptor family.
EPX protein networkhttps://string-db.org/network/9606.ENSP00000225371Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosi [...]
CRYBA1 protein networkhttps://string-db.org/network/9606.ENSP00000225387Beta-crystallin A3, isoform A1, Delta4 form; Crystallins are the dominant structural components of the vertebrate eye lens.
NUFIP2 protein networkhttps://string-db.org/network/9606.ENSP00000225388Nuclear fragile X mental retardation-interacting protein 2; Binds RNA.
RPL19 protein networkhttps://string-db.org/network/9606.ENSP00000225430Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family.
CSF3 protein networkhttps://string-db.org/network/9606.ENSP00000225474Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 [...]
SUPT4H1 protein networkhttps://string-db.org/network/9606.ENSP00000225504Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. D [...]
WNT3 protein networkhttps://string-db.org/network/9606.ENSP00000225512Proto-oncogene Wnt-3; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcr [...]
SHPK protein networkhttps://string-db.org/network/9606.ENSP00000225519Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism.
TAX1BP3 protein networkhttps://string-db.org/network/9606.ENSP00000225525Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling path [...]
P2RX1 protein networkhttps://string-db.org/network/9606.ENSP00000225538P2X purinoceptor 1; Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to b [...]
KRT37 protein networkhttps://string-db.org/network/9606.ENSP00000225550Keratin, type I cuticular Ha7; Keratin 37.
TVP23C protein networkhttps://string-db.org/network/9606.ENSP00000225576Trans-golgi network vesicle protein 23 homolog C; Belongs to the TVP23 family.
RPS6KB1 protein networkhttps://string-db.org/network/9606.ENSP00000225577Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth a [...]
PIGL protein networkhttps://string-db.org/network/9606.ENSP00000225609N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol; Belongs to the PIGL fami [...]
GALK1 protein networkhttps://string-db.org/network/9606.ENSP00000225614Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily.
PFN1 protein networkhttps://string-db.org/network/9606.ENSP00000225655Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By b [...]
SLC25A11 protein networkhttps://string-db.org/network/9606.ENSP00000225665Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxyl [...]
RASD1 protein networkhttps://string-db.org/network/9606.ENSP00000225688Dexamethasone-induced Ras-related protein 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similar [...]
C1QBP protein networkhttps://string-db.org/network/9606.ENSP00000225698Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome [...]
CPD protein networkhttps://string-db.org/network/9606.ENSP00000225719Carboxypeptidase D.
GOSR1 protein networkhttps://string-db.org/network/9606.ENSP00000225724Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or sol [...]
CCDC47 protein networkhttps://string-db.org/network/9606.ENSP00000225726Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum. Required for proper protein degradation via the ERAD pathway. Has an [...]
MED31 protein networkhttps://string-db.org/network/9606.ENSP00000225728Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
DRG2 protein networkhttps://string-db.org/network/9606.ENSP00000225729Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may b [...]
AKAP10 protein networkhttps://string-db.org/network/9606.ENSP00000225737A-kinase anchor protein 10, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma m [...]
DDX5 protein networkhttps://string-db.org/network/9606.ENSP00000225792Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a [...]
ASIC2 protein networkhttps://string-db.org/network/9606.ENSP00000225823Acid-sensing ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Gener [...]
CCL2 protein networkhttps://string-db.org/network/9606.ENSP00000225831C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular [...]
CCL1 protein networkhttps://string-db.org/network/9606.ENSP00000225842C-C motif chemokine 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8; Belongs to the intercrine beta (chemokine CC) family.
CCL13 protein networkhttps://string-db.org/network/9606.ENSP00000225844C-C motif chemokine 13, medium chain; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a ro [...]
KRT32 protein networkhttps://string-db.org/network/9606.ENSP00000225899Keratin, type I cuticular Ha2; Keratin 32; Belongs to the intermediate filament family.
KAT2A protein networkhttps://string-db.org/network/9606.ENSP00000225916Histone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context. Acts as a histone lysine [...]
NAGLU protein networkhttps://string-db.org/network/9606.ENSP00000225927Alpha-N-acetylglucosaminidase 77 kDa form; Involved in the degradation of heparan sulfate.
HSD17B1 protein networkhttps://string-db.org/network/9606.ENSP00000225929Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20- alpha-HSD activity. Uses preferentially NADH; Belongs to the short-chain dehydrogenases/reductases [...]
ABI3 protein networkhttps://string-db.org/network/9606.ENSP00000225941ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family.
COL1A1 protein networkhttps://string-db.org/network/9606.ENSP00000225964Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen).
MRPL27 protein networkhttps://string-db.org/network/9606.ENSP00000225969Mitochondrial ribosomal protein L27.
LRRC59 protein networkhttps://string-db.org/network/9606.ENSP00000225972Leucine-rich repeat-containing protein 59, N-terminally processed; Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating inter [...]
HDAC5 protein networkhttps://string-db.org/network/9606.ENSP00000225983Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
DUSP3 protein networkhttps://string-db.org/network/9606.ENSP00000226004Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dep [...]
CACNG1 protein networkhttps://string-db.org/network/9606.ENSP00000226021Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactiv [...]
HLF protein networkhttps://string-db.org/network/9606.ENSP00000226067Hepatic leukemia factor; HLF transcription factor, PAR bZIP family member; Belongs to the bZIP family. PAR subfamily.
EFNB3 protein networkhttps://string-db.org/network/9606.ENSP00000226091Ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithel [...]
RANGRF protein networkhttps://string-db.org/network/9606.ENSP00000226105Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of [...]
RCVRN protein networkhttps://string-db.org/network/9606.ENSP00000226193Recoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditio [...]
MYH1 protein networkhttps://string-db.org/network/9606.ENSP00000226207Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
VTN protein networkhttps://string-db.org/network/9606.ENSP00000226218Vitronectin V10 subunit; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain m [...]
TNFAIP1 protein networkhttps://string-db.org/network/9606.ENSP00000226225BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of c [...]
TMEM97 protein networkhttps://string-db.org/network/9606.ENSP00000226230Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, w [...]
FOXN1 protein networkhttps://string-db.org/network/9606.ENSP00000226247Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts [...]
CD38 protein networkhttps://string-db.org/network/9606.ENSP00000226279ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-ind [...]
IBSP protein networkhttps://string-db.org/network/9606.ENSP00000226284Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cel [...]
LAP3 protein networkhttps://string-db.org/network/9606.ENSP00000226299Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; [...]
CXCL6 protein networkhttps://string-db.org/network/9606.ENSP00000226317Small-inducible cytokine B6, N-processed variant 1; Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotac [...]
JADE1 protein networkhttps://string-db.org/network/9606.ENSP00000226319Protein Jade-1; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetyl [...]
AFM protein networkhttps://string-db.org/network/9606.ENSP00000226355Afamin; Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WN [...]
PHOX2B protein networkhttps://string-db.org/network/9606.ENSP00000226382Paired mesoderm homeobox protein 2B; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neu [...]
GNRHR protein networkhttps://string-db.org/network/9606.ENSP00000226413Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing ho [...]
CWH43 protein networkhttps://string-db.org/network/9606.ENSP00000226432PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation.
SULT1E1 protein networkhttps://string-db.org/network/9606.ENSP00000226444Sulfotransferase 1E1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. Is a key enzyme in estr [...]
SMR3A protein networkhttps://string-db.org/network/9606.ENSP00000226460Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification. Belongs to the PROL1/PROL3 family.
PF4V1 protein networkhttps://string-db.org/network/9606.ENSP00000226524Platelet factor 4 variant(4-74); Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro); Belongs to the intercrine alpha (chemokine CxC) family.
NFKB1 protein networkhttps://string-db.org/network/9606.ENSP00000226574Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are in [...]
IL2 protein networkhttps://string-db.org/network/9606.ENSP00000226730Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune re [...]
WFS1 protein networkhttps://string-db.org/network/9606.ENSP00000226760Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store.
GAR1 protein networkhttps://string-db.org/network/9606.ENSP00000226796H/ACA ribonucleoprotein complex subunit 1; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...]
FRG1 protein networkhttps://string-db.org/network/9606.ENSP00000226798Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transp [...]
CLNK protein networkhttps://string-db.org/network/9606.ENSP00000226951Cytokine-dependent hematopoietic cell linker; An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signa [...]
FAM149A protein networkhttps://string-db.org/network/9606.ENSP00000227065Protein FAM149A; Family with sequence similarity 149 member A.
CD82 protein networkhttps://string-db.org/network/9606.ENSP00000227155CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway; Belongs to the tetraspanin (TM4SF) family.
SPI1 protein networkhttps://string-db.org/network/9606.ENSP00000227163Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be sp [...]
CTSC protein networkhttps://string-db.org/network/9606.ENSP00000227266Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino [...]
ZPR1 protein networkhttps://string-db.org/network/9606.ENSP00000227322Zinc finger protein ZPR1; Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the [...]
CRTAM protein networkhttps://string-db.org/network/9606.ENSP00000227348Cytotoxic and regulatory T-cell molecule; Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cel [...]
JHY protein networkhttps://string-db.org/network/9606.ENSP00000227349Jhy protein homolog; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces.
DTX4 protein networkhttps://string-db.org/network/9606.ENSP00000227451E3 ubiquitin-protein ligase DTX4; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity [...]
UNC93B1 protein networkhttps://string-db.org/network/9606.ENSP00000227471Protein unc-93 homolog B1; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of T [...]
PUS3 protein networkhttps://string-db.org/network/9606.ENSP00000227474tRNA pseudouridine(38/39) synthase; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
CCND1 protein networkhttps://string-db.org/network/9606.ENSP00000227507G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...]
CCDC86 protein networkhttps://string-db.org/network/9606.ENSP00000227520Coiled-coil domain containing 86.
PRPF19 protein networkhttps://string-db.org/network/9606.ENSP00000227524Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as componen [...]
TMEM109 protein networkhttps://string-db.org/network/9606.ENSP00000227525Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By s [...]
PANX1 protein networkhttps://string-db.org/network/9606.ENSP00000227638Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis.
APOC3 protein networkhttps://string-db.org/network/9606.ENSP00000227667Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Int [...]
IL10RA protein networkhttps://string-db.org/network/9606.ENSP00000227752Interleukin-10 receptor subunit alpha; Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by i [...]
GALNT18 protein networkhttps://string-db.org/network/9606.ENSP00000227756Polypeptide N-acetylgalactosaminyltransferase 18; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
PDHX protein networkhttps://string-db.org/network/9606.ENSP00000227868Pyruvate dehydrogenase protein X component, mitochondrial; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenas [...]
SLC15A3 protein networkhttps://string-db.org/network/9606.ENSP00000227880Solute carrier family 15 member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).
SCGB2A2 protein networkhttps://string-db.org/network/9606.ENSP00000227918Mammaglobin-A; Secretoglobin family 2A member 2; Belongs to the secretoglobin family. Lipophilin subfamily.
DGAT2 protein networkhttps://string-db.org/network/9606.ENSP00000228027Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substr [...]
C11orf58 protein networkhttps://string-db.org/network/9606.ENSP00000228136Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family.
YBX3 protein networkhttps://string-db.org/network/9606.ENSP00000228251Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have [...]
SLC25A3 protein networkhttps://string-db.org/network/9606.ENSP00000228318Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitoc [...]
POLR3B protein networkhttps://string-db.org/network/9606.ENSP00000228347DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest co [...]
CD69 protein networkhttps://string-db.org/network/9606.ENSP00000228434Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
PRDM4 protein networkhttps://string-db.org/network/9606.ENSP00000228437PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily.
CLEC2B protein networkhttps://string-db.org/network/9606.ENSP00000228438C-type lectin domain family 2 member B.
SELPLG protein networkhttps://string-db.org/network/9606.ENSP00000228463P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over va [...]
ASIC1 protein networkhttps://string-db.org/network/9606.ENSP00000228468Acid-sensing ion channel 1; Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channe [...]
DAO protein networkhttps://string-db.org/network/9606.ENSP00000228476D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent whi [...]
KCTD10 protein networkhttps://string-db.org/network/9606.ENSP00000228495BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiqui [...]
MLEC protein networkhttps://string-db.org/network/9606.ENSP00000228506Malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N- glycosylation (By similarity); Belongs to the malectin f [...]
MVK protein networkhttps://string-db.org/network/9606.ENSP00000228510Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis ; Belongs to the GHMP kinase family. Mevalonate ki [...]
CSRNP2 protein networkhttps://string-db.org/network/9606.ENSP00000228515Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis.
IL23A protein networkhttps://string-db.org/network/9606.ENSP00000228534Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acu [...]
SYT10 protein networkhttps://string-db.org/network/9606.ENSP00000228567Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required fo [...]
CYP27B1 protein networkhttps://string-db.org/network/9606.ENSP0000022860625-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting ste [...]
MYF6 protein networkhttps://string-db.org/network/9606.ENSP00000228641Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
MYF5 protein networkhttps://string-db.org/network/9606.ENSP00000228644Myogenic factor 5; Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies musc [...]
GLI1 protein networkhttps://string-db.org/network/9606.ENSP00000228682Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays [...]
PPM1H protein networkhttps://string-db.org/network/9606.ENSP00000228705Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
LTA4H protein networkhttps://string-db.org/network/9606.ENSP00000228740Leukotriene A-4 hydrolase; Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
ELK3 protein networkhttps://string-db.org/network/9606.ENSP00000228741ETS domain-containing protein Elk-3; May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum res [...]
ITFG2 protein networkhttps://string-db.org/network/9606.ENSP00000228799KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 [...]
PRR4 protein networkhttps://string-db.org/network/9606.ENSP00000228811Proline-rich protein 4; Proline rich 4.
PARP11 protein networkhttps://string-db.org/network/9606.ENSP00000228820Protein mono-ADP-ribosyltransferase PARP11; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling [...]
ARPC3 protein networkhttps://string-db.org/network/9606.ENSP00000228825Actin-related protein 2/3 complex subunit 3; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The [...]
FGF6 protein networkhttps://string-db.org/network/9606.ENSP00000228837Fibroblast growth factor 6; Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration. Bel [...]
MYL2 protein networkhttps://string-db.org/network/9606.ENSP00000228841Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a ro [...]
RAD51AP1 protein networkhttps://string-db.org/network/9606.ENSP00000228843RAD51-associated protein 1; May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double- strand break repair. Functionally cooper [...]
AKAP3 protein networkhttps://string-db.org/network/9606.ENSP00000228850A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction.
CREBL2 protein networkhttps://string-db.org/network/9606.ENSP00000228865cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cel [...]
CDKN1B protein networkhttps://string-db.org/network/9606.ENSP00000228872Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SP [...]
GPRC5D protein networkhttps://string-db.org/network/9606.ENSP00000228887G protein-coupled receptor class C group 5 member D; Belongs to the G-protein coupled receptor 3 family.
LTBR protein networkhttps://string-db.org/network/9606.ENSP00000228918Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a r [...]
OGFOD2 protein networkhttps://string-db.org/network/9606.ENSP000002289222-oxoglutarate and iron dependent oxygenase domain containing 2.
OAS3 protein networkhttps://string-db.org/network/9606.ENSP000002289282'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in ot [...]
ART4 protein networkhttps://string-db.org/network/9606.ENSP00000228936ADP-ribosyltransferase 4; Belongs to the Arg-specific ADP-ribosyltransferase family.
MGP protein networkhttps://string-db.org/network/9606.ENSP00000228938Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
ARHGDIB protein networkhttps://string-db.org/network/9606.ENSP00000228945Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates [...]
RERGL protein networkhttps://string-db.org/network/9606.ENSP00000229002Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity.
FZD10 protein networkhttps://string-db.org/network/9606.ENSP00000229030Frizzled-10; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of [...]
IL26 protein networkhttps://string-db.org/network/9606.ENSP00000229134Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAP [...]
IFNG protein networkhttps://string-db.org/network/9606.ENSP00000229135Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent [...]
NUP107 protein networkhttps://string-db.org/network/9606.ENSP00000229179Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to [...]
CNOT2 protein networkhttps://string-db.org/network/9606.ENSP00000229195CCR4-NOT transcription complex subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...]
KRR1 protein networkhttps://string-db.org/network/9606.ENSP00000229214KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).
MRPL51 protein networkhttps://string-db.org/network/9606.ENSP00000229238Mitochondrial ribosomal protein L51; Belongs to the mitochondrion-specific ribosomal protein mL51 family.
ACRBP protein networkhttps://string-db.org/network/9606.ENSP00000229243Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.
GNB3 protein networkhttps://string-db.org/network/9606.ENSP00000229264Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...]
CHPT1 protein networkhttps://string-db.org/network/9606.ENSP00000229266Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
USP5 protein networkhttps://string-db.org/network/9606.ENSP00000229268Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin [...]
TPI1 protein networkhttps://string-db.org/network/9606.ENSP00000229270Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3 [...]
C12orf57 protein networkhttps://string-db.org/network/9606.ENSP00000229281Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family.
APOBEC1 protein networkhttps://string-db.org/network/9606.ENSP00000229304C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon [...]
NANOG protein networkhttps://string-db.org/network/9606.ENSP00000229307Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their diffe [...]
GOLT1B protein networkhttps://string-db.org/network/9606.ENSP00000229314Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
CMAS protein networkhttps://string-db.org/network/9606.ENSP00000229329N-acylneuraminate cytidylyltransferase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for th [...]
HCFC2 protein networkhttps://string-db.org/network/9606.ENSP00000229330Host cell factor C2.
CLEC4A protein networkhttps://string-db.org/network/9606.ENSP00000229332C-type lectin domain family 4 member A; C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner [...]
AICDA protein networkhttps://string-db.org/network/9606.ENSP00000229335Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lympho [...]
RAB35 protein networkhttps://string-db.org/network/9606.ENSP00000229340Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
COX6A1 protein networkhttps://string-db.org/network/9606.ENSP00000229379Cytochrome c oxidase subunit 6A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The r [...]
SRSF9 protein networkhttps://string-db.org/network/9606.ENSP00000229390Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. Belongs to th [...]
FGFR1OP2 protein networkhttps://string-db.org/network/9606.ENSP00000229395FGFR1 oncogene partner 2; May be involved in wound healing pathway; Belongs to the SIKE family.
KLRB1 protein networkhttps://string-db.org/network/9606.ENSP00000229402Killer cell lectin-like receptor subfamily B member 1; Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation w [...]
IYD protein networkhttps://string-db.org/network/9606.ENSP00000229447Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodi [...]
RSPH4A protein networkhttps://string-db.org/network/9606.ENSP00000229554Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin st [...]
ADTRP protein networkhttps://string-db.org/network/9606.ENSP00000229583Androgen-dependent TFPI-regulating protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branch [...]
ASF1A protein networkhttps://string-db.org/network/9606.ENSP00000229595Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly fact [...]
HINT3 protein networkhttps://string-db.org/network/9606.ENSP00000229633Histidine triad nucleotide-binding protein 3; Hydrolyzes phosphoramidate and acyl-adenylate substrates. Belongs to the HINT family.
ULBP1 protein networkhttps://string-db.org/network/9606.ENSP00000229708UL16-binding protein 1; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
SLC44A4 protein networkhttps://string-db.org/network/9606.ENSP00000229729Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundl [...]
FBXO5 protein networkhttps://string-db.org/network/9606.ENSP00000229758F-box only protein 5; Regulator of APC activity during mitotic and meiotic cell cycle. During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex. During G1 phase, [...]
FANCE protein networkhttps://string-db.org/network/9606.ENSP00000229769Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge betwe [...]
TULP1 protein networkhttps://string-db.org/network/9606.ENSP00000229771Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cy [...]
MAPK14 protein networkhttps://string-db.org/network/9606.ENSP00000229795Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an [...]
STK38 protein networkhttps://string-db.org/network/9606.ENSP00000229812Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K [...]
HLA-DOA protein networkhttps://string-db.org/network/9606.ENSP00000229829HLA class II histocompatibility antigen, DO alpha chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modif [...]
SAYSD1 protein networkhttps://string-db.org/network/9606.ENSP00000229903SAYSVFN motif domain containing 1.
CAP2 protein networkhttps://string-db.org/network/9606.ENSP00000229922Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family.
GPR63 protein networkhttps://string-db.org/network/9606.ENSP00000229955Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function.
GPLD1 protein networkhttps://string-db.org/network/9606.ENSP00000230036Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these [...]
ACOT13 protein networkhttps://string-db.org/network/9606.ENSP00000230048Acyl-coenzyme A thioesterase 13, N-terminally processed; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), pro [...]
RPS12 protein networkhttps://string-db.org/network/9606.ENSP00000230050Ribosomal protein S12.
B3GAT2 protein networkhttps://string-db.org/network/9606.ENSP00000230053Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.
GMNN protein networkhttps://string-db.org/network/9606.ENSP00000230056Geminin; Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction [...]
SNX3 protein networkhttps://string-db.org/network/9606.ENSP00000230085Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol [...]
ZBTB24 protein networkhttps://string-db.org/network/9606.ENSP00000230122Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription.
FIG4 protein networkhttps://string-db.org/network/9606.ENSP00000230124Polyphosphoinositide phosphatase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all thr [...]
UNC93A protein networkhttps://string-db.org/network/9606.ENSP00000230256Unc-93 homolog A.
C6orf118 protein networkhttps://string-db.org/network/9606.ENSP00000230301Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118.
MDFI protein networkhttps://string-db.org/network/9606.ENSP00000230321MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in th [...]
BYSL protein networkhttps://string-db.org/network/9606.ENSP00000230340Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin- dependent regulation of cell adhesion during implantation of hum [...]
TBP protein networkhttps://string-db.org/network/9606.ENSP00000230354TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional ste [...]
GUCA1B protein networkhttps://string-db.org/network/9606.ENSP00000230361Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calci [...]
PRPH2 protein networkhttps://string-db.org/network/9606.ENSP00000230381Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for [...]
DNPH1 protein networkhttps://string-db.org/network/9606.ENSP000002304312'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine [...]
EXOC2 protein networkhttps://string-db.org/network/9606.ENSP00000230449Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC5 family.
TMEM30A protein networkhttps://string-db.org/network/9606.ENSP00000230461Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inne [...]
LAMA4 protein networkhttps://string-db.org/network/9606.ENSP00000230538Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
PRSS16 protein networkhttps://string-db.org/network/9606.ENSP00000230582Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family.
MEP1A protein networkhttps://string-db.org/network/9606.ENSP00000230588Meprin A subunit alpha.
MTREX protein networkhttps://string-db.org/network/9606.ENSP00000230640Exosome RNA helicase MTR4; Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exo [...]
ISL1 protein networkhttps://string-db.org/network/9606.ENSP00000230658Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamen [...]
SLC6A7 protein networkhttps://string-db.org/network/9606.ENSP00000230671Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals.
NUDT12 protein networkhttps://string-db.org/network/9606.ENSP00000230792Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine tripho [...]
HBEGF protein networkhttps://string-db.org/network/9606.ENSP00000230990Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smoot [...]
LOX protein networkhttps://string-db.org/network/9606.ENSP00000231004Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expr [...]
GZMK protein networkhttps://string-db.org/network/9606.ENSP00000231009Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily.
CDH9 protein networkhttps://string-db.org/network/9606.ENSP00000231021Cadherin-9; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
SPARC protein networkhttps://string-db.org/network/9606.ENSP00000231061SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cel [...]
HAND1 protein networkhttps://string-db.org/network/9606.ENSP00000231121Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similari [...]
PCDHB3 protein networkhttps://string-db.org/network/9606.ENSP00000231130Protocadherin beta-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB5 protein networkhttps://string-db.org/network/9606.ENSP00000231134Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB6 protein networkhttps://string-db.org/network/9606.ENSP00000231136Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of speci [...]
PCDHB7 protein networkhttps://string-db.org/network/9606.ENSP00000231137Protocadherin beta-7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB15 protein networkhttps://string-db.org/network/9606.ENSP00000231173Protocadherin beta-15; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
THG1L protein networkhttps://string-db.org/network/9606.ENSP00000231198Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidel [...]
IL12B protein networkhttps://string-db.org/network/9606.ENSP00000231228Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the productio [...]
TTC1 protein networkhttps://string-db.org/network/9606.ENSP00000231238Tetratricopeptide repeat domain 1.
LNPEP protein networkhttps://string-db.org/network/9606.ENSP00000231368Leucyl-cystinyl aminopeptidase, pregnancy serum form; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytoci [...]
AGXT2 protein networkhttps://string-db.org/network/9606.ENSP00000231420Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is [...]
IL4 protein networkhttps://string-db.org/network/9606.ENSP00000231449Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecu [...]
IL5 protein networkhttps://string-db.org/network/9606.ENSP00000231454Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells; Belongs to the IL-5 family.
ST8SIA4 protein networkhttps://string-db.org/network/9606.ENSP00000231461CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on t [...]
PCDH12 protein networkhttps://string-db.org/network/9606.ENSP00000231484Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity). Acts as a regulator of cell mi [...]
SKP1 protein networkhttps://string-db.org/network/9606.ENSP00000231487S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progre [...]
NUP155 protein networkhttps://string-db.org/network/9606.ENSP00000231498Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins [...]
NR3C1 protein networkhttps://string-db.org/network/9606.ENSP00000231509Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitocho [...]
C5orf15 protein networkhttps://string-db.org/network/9606.ENSP00000231512Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15.
TRIM23 protein networkhttps://string-db.org/network/9606.ENSP00000231524E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase [...]
RARS1 protein networkhttps://string-db.org/network/9606.ENSP00000231572Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion [...]
CDX1 protein networkhttps://string-db.org/network/9606.ENSP00000231656Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 pr [...]
BNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000231668Vesicle transport protein SEC20; As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Pl [...]
SLC7A14 protein networkhttps://string-db.org/network/9606.ENSP00000231706Probable cationic amino acid transporter; May be involved in arginine transport. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A. [...]
SEMA3G protein networkhttps://string-db.org/network/9606.ENSP00000231721Semaphorin-3G; Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity); Belongs to the semaphorin family.
ZMYND10 protein networkhttps://string-db.org/network/9606.ENSP00000231749Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respect [...]
LTF protein networkhttps://string-db.org/network/9606.ENSP00000231751Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin binds to the bact [...]
MLH1 protein networkhttps://string-db.org/network/9606.ENSP00000231790DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-M [...]
EHHADH protein networkhttps://string-db.org/network/9606.ENSP00000231887Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CRBN protein networkhttps://string-db.org/network/9606.ENSP00000231948Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, [...]
HRG protein networkhttps://string-db.org/network/9606.ENSP00000232003Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and hep [...]
RBP2 protein networkhttps://string-db.org/network/9606.ENSP00000232217Retinol-binding protein 2; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
RBP1 protein networkhttps://string-db.org/network/9606.ENSP00000232219Retinol-binding protein 1; Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis. Belo [...]
PFKFB4 protein networkhttps://string-db.org/network/9606.ENSP000002323756-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family.
HES1 protein networkhttps://string-db.org/network/9606.ENSP00000232424Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MY [...]
GNAT1 protein networkhttps://string-db.org/network/9606.ENSP00000232461Guanine nucleotide-binding protein G(t) subunit alpha-1; Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina. Guanine nuc [...]
TUSC2 protein networkhttps://string-db.org/network/9606.ENSP00000232496Tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cel [...]
NPRL2 protein networkhttps://string-db.org/network/9606.ENSP00000232501GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrol [...]
GNB4 protein networkhttps://string-db.org/network/9606.ENSP00000232564Guanine nucleotide-binding protein subunit beta-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta [...]
MORC1 protein networkhttps://string-db.org/network/9606.ENSP00000232603MORC family CW-type zinc finger protein 1; Required for spermatogenesis.
UMPS protein networkhttps://string-db.org/network/9606.ENSP00000232607Orotidine 5'-phosphate decarboxylase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family.
ABTB1 protein networkhttps://string-db.org/network/9606.ENSP00000232744Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes.
KLHL18 protein networkhttps://string-db.org/network/9606.ENSP00000232766Kelch-like protein 18; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL18) E3 ubiquitin ligas [...]
RRP9 protein networkhttps://string-db.org/network/9606.ENSP00000232888U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal [...]
AADAC protein networkhttps://string-db.org/network/9606.ENSP00000232892Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stor [...]
EIF1B protein networkhttps://string-db.org/network/9606.ENSP00000232905Eukaryotic translation initiation factor 1b; Probably involved in translation.
ZBTB47 protein networkhttps://string-db.org/network/9606.ENSP00000232974Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation.
TNNC1 protein networkhttps://string-db.org/network/9606.ENSP00000232975Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosi [...]
NKTR protein networkhttps://string-db.org/network/9606.ENSP00000232978NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative [...]
SPCS1 protein networkhttps://string-db.org/network/9606.ENSP00000233025Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endopla [...]
NEK4 protein networkhttps://string-db.org/network/9606.ENSP00000233027Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited num [...]
WDFY1 protein networkhttps://string-db.org/network/9606.ENSP00000233055WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand [...]
EIF2AK2 protein networkhttps://string-db.org/network/9606.ENSP00000233057Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infecti [...]
DAZAP1 protein networkhttps://string-db.org/network/9606.ENSP00000233078DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis.
HEATR5B protein networkhttps://string-db.org/network/9606.ENSP00000233099HEAT repeat containing 5B; Belongs to the HEATR5 family.
MAPRE3 protein networkhttps://string-db.org/network/9606.ENSP00000233121Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promo [...]
TMSB10 protein networkhttps://string-db.org/network/9606.ENSP00000233143Thymosin beta-10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Be [...]
MSH2 protein networkhttps://string-db.org/network/9606.ENSP00000233146DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 [...]
NCK2 protein networkhttps://string-db.org/network/9606.ENSP00000233154Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by pro [...]
TFPI protein networkhttps://string-db.org/network/9606.ENSP00000233156Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It [...]
SLC11A1 protein networkhttps://string-db.org/network/9606.ENSP00000233202Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-spe [...]
APOB protein networkhttps://string-db.org/network/9606.ENSP00000233242Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellul [...]
INO80B protein networkhttps://string-db.org/network/9606.ENSP00000233331INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle.
TTL protein networkhttps://string-db.org/network/9606.ENSP00000233336Tubulin--tyrosine ligase; Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
FAHD2A protein networkhttps://string-db.org/network/9606.ENSP00000233379Fumarylacetoacetate hydrolase domain-containing protein 2A; May have hydrolase activity.
SF3B6 protein networkhttps://string-db.org/network/9606.ENSP00000233468Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...]
SLC30A3 protein networkhttps://string-db.org/network/9606.ENSP00000233535Zinc transporter 3; Involved in accumulation of zinc in synaptic vesicles.
SNX17 protein networkhttps://string-db.org/network/9606.ENSP00000233575Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of [...]
REEP6 protein networkhttps://string-db.org/network/9606.ENSP00000233596Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates [...]
WBP1 protein networkhttps://string-db.org/network/9606.ENSP00000233615WW domain binding protein 1.
TTC31 protein networkhttps://string-db.org/network/9606.ENSP00000233623Tetratricopeptide repeat domain 31.
NDUFS7 protein networkhttps://string-db.org/network/9606.ENSP00000233627NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...]
PCGF1 protein networkhttps://string-db.org/network/9606.ENSP00000233630Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as [...]
TLX2 protein networkhttps://string-db.org/network/9606.ENSP00000233638T-cell leukemia homeobox protein 2; Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of ent [...]
DOK1 protein networkhttps://string-db.org/network/9606.ENSP00000233668Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be [...]
ACADL protein networkhttps://string-db.org/network/9606.ENSP00000233710Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty aci [...]
REG1A protein networkhttps://string-db.org/network/9606.ENSP00000233735Lithostathine-1-alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
IGFBP2 protein networkhttps://string-db.org/network/9606.ENSP00000233809Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF- binding proteins prolong the half-life of the IGFs and have been shown to either inhibit o [...]
IGFBP5 protein networkhttps://string-db.org/network/9606.ENSP00000233813Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...]
KCNJ13 protein networkhttps://string-db.org/network/9606.ENSP00000233826Inward rectifier potassium channel 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...]
GGCX protein networkhttps://string-db.org/network/9606.ENSP00000233838Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversio [...]
NEU2 protein networkhttps://string-db.org/network/9606.ENSP00000233840Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides.
HSPE1 protein networkhttps://string-db.org/network/9606.ENSP0000023389310 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported pr [...]
WNT6 protein networkhttps://string-db.org/network/9606.ENSP00000233948Protein Wnt-6; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete re [...]
IL1RL1 protein networkhttps://string-db.org/network/9606.ENSP00000233954Interleukin-1 receptor-like 1; Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by p [...]
SLC9A2 protein networkhttps://string-db.org/network/9606.ENSP00000233969Sodium/hydrogen exchanger 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
AZU1 protein networkhttps://string-db.org/network/9606.ENSP00000233997Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gr [...]
PPP1R7 protein networkhttps://string-db.org/network/9606.ENSP00000234038Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family.
PROC protein networkhttps://string-db.org/network/9606.ENSP00000234071Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions [...]
ID2 protein networkhttps://string-db.org/network/9606.ENSP00000234091DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...]
ODC1 protein networkhttps://string-db.org/network/9606.ENSP00000234111Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and sp [...]
GORASP2 protein networkhttps://string-db.org/network/9606.ENSP00000234160Golgi reassembly-stacking protein 2; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and [...]
CEBPZ protein networkhttps://string-db.org/network/9606.ENSP00000234170CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family.
RMDN2 protein networkhttps://string-db.org/network/9606.ENSP00000234195Regulator of microtubule dynamics 2; Belongs to the RMDN family.
DLX2 protein networkhttps://string-db.org/network/9606.ENSP00000234198Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play [...]
SLC1A4 protein networkhttps://string-db.org/network/9606.ENSP00000234256Neutral amino acid transporter A; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.
ORC2 protein networkhttps://string-db.org/network/9606.ENSP00000234296Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...]
PPP3R1 protein networkhttps://string-db.org/network/9606.ENSP00000234310Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
PLEK protein networkhttps://string-db.org/network/9606.ENSP00000234313Pleckstrin; Major protein kinase C substrate of platelets.
PRTN3 protein networkhttps://string-db.org/network/9606.ENSP00000234347Myeloblastin; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances end [...]
KISS1R protein networkhttps://string-db.org/network/9606.ENSP00000234371KiSS-1 receptor; Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melano [...]
GRIN3B protein networkhttps://string-db.org/network/9606.ENSP00000234389Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivi [...]
VAX2 protein networkhttps://string-db.org/network/9606.ENSP00000234392Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression [...]
ATP6V1B1 protein networkhttps://string-db.org/network/9606.ENSP00000234396V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartmen [...]
MSH6 protein networkhttps://string-db.org/network/9606.ENSP00000234420DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiatin [...]
PLEKHA3 protein networkhttps://string-db.org/network/9606.ENSP00000234453Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4- phosphate [...]
SPR protein networkhttps://string-db.org/network/9606.ENSP00000234454Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin; Belongs to the sepiapterin reductase family.
CLCN6 protein networkhttps://string-db.org/network/9606.ENSP00000234488Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functio [...]
CLCA1 protein networkhttps://string-db.org/network/9606.ENSP00000234701Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cysti [...]
BCL9 protein networkhttps://string-db.org/network/9606.ENSP00000234739B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity). Belongs to the BCL9 family.
TPSG1 protein networkhttps://string-db.org/network/9606.ENSP00000234798Tryptase gamma 1.
ANGPTL1 protein networkhttps://string-db.org/network/9606.ENSP00000234816Angiopoietin-related protein 1; Angiopoietin like 1.
TCEANC2 protein networkhttps://string-db.org/network/9606.ENSP00000234827Transcription elongation factor A N-terminal and central domain containing 2.
TMEM59 protein networkhttps://string-db.org/network/9606.ENSP00000234831Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, lea [...]
OPRD1 protein networkhttps://string-db.org/network/9606.ENSP00000234961Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that tr [...]
WDR77 protein networkhttps://string-db.org/network/9606.ENSP00000235090Methylosome protein 50; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm [...]
C1orf21 protein networkhttps://string-db.org/network/9606.ENSP00000235307Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21.
MAD2L2 protein networkhttps://string-db.org/network/9606.ENSP00000235310Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the er [...]
MIIP protein networkhttps://string-db.org/network/9606.ENSP00000235332Migration and invasion-inhibitory protein; Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 o [...]
SLC35D1 protein networkhttps://string-db.org/network/9606.ENSP00000235345UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic retic [...]
PRAMEF10 protein networkhttps://string-db.org/network/9606.ENSP00000235347PRAME family member 10; Belongs to the PRAME family.
PRAMEF4 protein networkhttps://string-db.org/network/9606.ENSP00000235349PRAME family member 4; Belongs to the PRAME family.
PRDM2 protein networkhttps://string-db.org/network/9606.ENSP00000235372PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor [...]
RGS2 protein networkhttps://string-db.org/network/9606.ENSP00000235382Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...]
WARS2 protein networkhttps://string-db.org/network/9606.ENSP00000235521Tryptophan--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial gen [...]
NT5C1A protein networkhttps://string-db.org/network/9606.ENSP00000235628Cytosolic 5'-nucleotidase 1A; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ische [...]
AKR7A2 protein networkhttps://string-db.org/network/9606.ENSP00000235835Aflatoxin B1 aldehyde reductase member 2; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gam [...]
P3H1 protein networkhttps://string-db.org/network/9606.ENSP00000236040Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in [...]
SLC19A2 protein networkhttps://string-db.org/network/9606.ENSP00000236137Thiamine transporter 1; High-affinity transporter for the intake of thiamine.
VAMP4 protein networkhttps://string-db.org/network/9606.ENSP00000236192Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory [...]
SYF2 protein networkhttps://string-db.org/network/9606.ENSP00000236273Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome. Belongs to the SYF2 family.
SLC5A9 protein networkhttps://string-db.org/network/9606.ENSP00000236495Sodium/glucose cotransporter 4; Involved in sodium-dependent transport of D-mannose, D- glucose and D-fructose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
CTSD protein networkhttps://string-db.org/network/9606.ENSP00000236671Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involv [...]
A4GNT protein networkhttps://string-db.org/network/9606.ENSP00000236709Alpha-1,4-N-acetylglucosaminyltransferase; Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically [...]
MMP8 protein networkhttps://string-db.org/network/9606.ENSP00000236826Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens; Belongs to the peptidase M10A family.
APOA1 protein networkhttps://string-db.org/network/9606.ENSP00000236850Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor [...]
SLC8A2 protein networkhttps://string-db.org/network/9606.ENSP00000236877Sodium/calcium exchanger 2; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca [...]
CAMSAP2 protein networkhttps://string-db.org/network/9606.ENSP00000236925Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...]
ATIC protein networkhttps://string-db.org/network/9606.ENSP00000236959Bifunctional purine biosynthesis protein PURH, N-terminally processed; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family.
TNP1 protein networkhttps://string-db.org/network/9606.ENSP00000236979Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes [...]
TTR protein networkhttps://string-db.org/network/9606.ENSP00000237014Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
DOP1A protein networkhttps://string-db.org/network/9606.ENSP00000237163Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family.
FILIP1 protein networkhttps://string-db.org/network/9606.ENSP00000237172Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation o [...]
SPACA1 protein networkhttps://string-db.org/network/9606.ENSP00000237201Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis (By similarity). Important for male fertility.
TBPL1 protein networkhttps://string-db.org/network/9606.ENSP00000237264TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter [...]
ZC2HC1B protein networkhttps://string-db.org/network/9606.ENSP00000237275Zinc finger C2HC-type containing 1B; Belongs to the ZC2HC1 family.
FBXO30 protein networkhttps://string-db.org/network/9606.ENSP00000237281F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.
ADAT2 protein networkhttps://string-db.org/network/9606.ENSP00000237283tRNA-specific adenosine deaminase 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs.
PMFBP1 protein networkhttps://string-db.org/network/9606.ENSP00000237353Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, [...]
MED28 protein networkhttps://string-db.org/network/9606.ENSP00000237380Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
RNF103 protein networkhttps://string-db.org/network/9606.ENSP00000237455E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.
RPN2 protein networkhttps://string-db.org/network/9606.ENSP00000237530Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Ma [...]
SOGA1 protein networkhttps://string-db.org/network/9606.ENSP00000237536C-terminal 80 kDa form; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. Belongs to the SOGA family.
PKD2 protein networkhttps://string-db.org/network/9606.ENSP00000237596Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can [...]
STBD1 protein networkhttps://string-db.org/network/9606.ENSP00000237642Starch-binding domain-containing protein 1; Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosom [...]
CCNI protein networkhttps://string-db.org/network/9606.ENSP00000237654Cyclin-I; Cyclin I; Belongs to the cyclin family.
RARRES1 protein networkhttps://string-db.org/network/9606.ENSP00000237696Retinoic acid receptor responder protein 1; Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle.
LDAH protein networkhttps://string-db.org/network/9606.ENSP00000237822Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote c [...]
FGF23 protein networkhttps://string-db.org/network/9606.ENSP00000237837Fibroblast growth factor 23 C-terminal peptide; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the prese [...]
ELL2 protein networkhttps://string-db.org/network/9606.ENSP00000237853RNA polymerase II elongation factor ELL2; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription b [...]
GDA protein networkhttps://string-db.org/network/9606.ENSP00000238018Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
ECRG4 protein networkhttps://string-db.org/network/9606.ENSP00000238044Augurin; Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (By similarity). ECRG4-induced se [...]
CPSF3 protein networkhttps://string-db.org/network/9606.ENSP00000238112Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...]
DDX55 protein networkhttps://string-db.org/network/9606.ENSP00000238146ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase.
CCDC92 protein networkhttps://string-db.org/network/9606.ENSP00000238156Coiled-coil domain containing 92.
HDHD3 protein networkhttps://string-db.org/network/9606.ENSP00000238379Haloacid dehalogenase like hydrolase domain containing 3.
VPS4B protein networkhttps://string-db.org/network/9606.ENSP00000238497Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes thei [...]
SERPINB10 protein networkhttps://string-db.org/network/9606.ENSP00000238508Serpin B10; Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm a [...]
GSC protein networkhttps://string-db.org/network/9606.ENSP00000238558Homeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, [...]
ADCK1 protein networkhttps://string-db.org/network/9606.ENSP00000238561AarF domain-containing protein kinase 1; Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase- independent manner to [...]
IFI27L2 protein networkhttps://string-db.org/network/9606.ENSP00000238609Interferon alpha-inducible protein 27-like protein 2; Plays a role in the apoptotic process and has a pro-apoptotic activity.
NEK9 protein networkhttps://string-db.org/network/9606.ENSP00000238616Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, [...]
IFT43 protein networkhttps://string-db.org/network/9606.ENSP00000238628Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPC [...]
IRF2BPL protein networkhttps://string-db.org/network/9606.ENSP00000238647Probable E3 ubiquitin-protein ligase IRF2BPL; Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation [...]
ACOT2 protein networkhttps://string-db.org/network/9606.ENSP00000238651Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...]
FLVCR2 protein networkhttps://string-db.org/network/9606.ENSP00000238667Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism.
TGFB3 protein networkhttps://string-db.org/network/9606.ENSP00000238682Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) ch [...]
PAPOLG protein networkhttps://string-db.org/network/9606.ENSP00000238714Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclea [...]
TP53I3 protein networkhttps://string-db.org/network/9606.ENSP00000238721Quinone oxidoreductase PIG3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-nap [...]
RHOQ protein networkhttps://string-db.org/network/9606.ENSP00000238738Rho-related GTP-binding protein RhoQ; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effec [...]
TMEM214 protein networkhttps://string-db.org/network/9606.ENSP00000238788Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum str [...]
ATAD2B protein networkhttps://string-db.org/network/9606.ENSP00000238789ATPase family AAA domain containing 2B.
FAM98A protein networkhttps://string-db.org/network/9606.ENSP00000238823Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffl [...]
YIPF4 protein networkhttps://string-db.org/network/9606.ENSP00000238831Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family.
AFTPH protein networkhttps://string-db.org/network/9606.ENSP00000238855Aftiphilin; May play a role in membrane trafficking.
LGALSL protein networkhttps://string-db.org/network/9606.ENSP00000238875Galectin-related protein; Does not bind lactose, and may not bind carbohydrates.
CRIPT protein networkhttps://string-db.org/network/9606.ENSP00000238892Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.
MFSD13A protein networkhttps://string-db.org/network/9606.ENSP00000238936Transmembrane protein 180; Major facilitator superfamily domain containing 13A.
PPP1R3C protein networkhttps://string-db.org/network/9606.ENSP00000238994Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limi [...]
PRLHR protein networkhttps://string-db.org/network/9606.ENSP00000239032Prolactin-releasing peptide receptor; Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing; Belongs to the G-protein coup [...]
HOXB8 protein networkhttps://string-db.org/network/9606.ENSP00000239144Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
HOXB5 protein networkhttps://string-db.org/network/9606.ENSP00000239151Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
HOXB7 protein networkhttps://string-db.org/network/9606.ENSP00000239165Homeobox protein Hox-B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
DUSP1 protein networkhttps://string-db.org/network/9606.ENSP00000239223Dual specificity protein phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell c [...]
PANK3 protein networkhttps://string-db.org/network/9606.ENSP00000239231Pantothenate kinase 3; Plays a role in the physiological regulation of coenzyme A (CoA) levels; Belongs to the type II pantothenate kinase family.
MSX2 protein networkhttps://string-db.org/network/9606.ENSP00000239243Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during oste [...]
INSL4 protein networkhttps://string-db.org/network/9606.ENSP00000239316Early placenta insulin-like peptide A chain; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family.
IFNA7 protein networkhttps://string-db.org/network/9606.ENSP00000239347Interferon alpha-7; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...]
LRP11 protein networkhttps://string-db.org/network/9606.ENSP00000239367Low-density lipoprotein receptor-related protein 11; LDL receptor related protein 11; Belongs to the LDLR family.
CCDC170 protein networkhttps://string-db.org/network/9606.ENSP00000239374Coiled-coil domain containing 170.
ARAP3 protein networkhttps://string-db.org/network/9606.ENSP00000239440Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodel [...]
PCDHB8 protein networkhttps://string-db.org/network/9606.ENSP00000239444Protocadherin beta-8; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of speci [...]
PCDHB10 protein networkhttps://string-db.org/network/9606.ENSP00000239446Protocadherin beta-10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB14 protein networkhttps://string-db.org/network/9606.ENSP00000239449Protocadherin beta-14; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHB12 protein networkhttps://string-db.org/network/9606.ENSP00000239450Protocadherin beta-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
SLC25A2 protein networkhttps://string-db.org/network/9606.ENSP00000239451Mitochondrial ornithine transporter 2; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family.
PRRX1 protein networkhttps://string-db.org/network/9606.ENSP00000239461Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein bind [...]
TNN protein networkhttps://string-db.org/network/9606.ENSP00000239462Tenascin-N; Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity). Involved in neurite outgrowth and cell migration in hippocampal ex [...]
TTLL2 protein networkhttps://string-db.org/network/9606.ENSP00000239587Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Belongs [...]
PDZD11 protein networkhttps://string-db.org/network/9606.ENSP00000239666PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33.
NUDCD1 protein networkhttps://string-db.org/network/9606.ENSP00000239690NudC domain containing 1.
CCDC77 protein networkhttps://string-db.org/network/9606.ENSP00000239830Coiled-coil domain containing 77.
ELF1 protein networkhttps://string-db.org/network/9606.ENSP00000239882ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expre [...]
ALG5 protein networkhttps://string-db.org/network/9606.ENSP00000239891ALG5 dolichyl-phosphate beta-glucosyltransferase.
FAM53C protein networkhttps://string-db.org/network/9606.ENSP00000239906Protein FAM53C; Family with sequence similarity 53 member C.
MYOT protein networkhttps://string-db.org/network/9606.ENSP00000239926Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; Belongs to the myotilin/pall [...]
EGR1 protein networkhttps://string-db.org/network/9606.ENSP00000239938Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds do [...]
PFN2 protein networkhttps://string-db.org/network/9606.ENSP00000239940Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By b [...]
NFYB protein networkhttps://string-db.org/network/9606.ENSP00000240055Nuclear transcription factor Y subunit beta; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promo [...]
WASHC3 protein networkhttps://string-db.org/network/9606.ENSP00000240079WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...]
FZD3 protein networkhttps://string-db.org/network/9606.ENSP00000240093Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...]
DUSP4 protein networkhttps://string-db.org/network/9606.ENSP00000240100Dual specificity protein phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Belongs to the protein-tyrosine phosph [...]
SORBS3 protein networkhttps://string-db.org/network/9606.ENSP00000240123Vinexin; Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to E [...]
TARDBP protein networkhttps://string-db.org/network/9606.ENSP00000240185TAR DNA-binding protein 43; RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-r [...]
PRAMEF2 protein networkhttps://string-db.org/network/9606.ENSP00000240189PRAME family member 2; Belongs to the PRAME family.
RDH10 protein networkhttps://string-db.org/network/9606.ENSP00000240285Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol [...]
DLX4 protein networkhttps://string-db.org/network/9606.ENSP00000240306Homeobox protein DLX-4; May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis; Belongs to the distal-l [...]
COIL protein networkhttps://string-db.org/network/9606.ENSP00000240316Coilin; Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs; Belongs to the coilin family.
TBX2 protein networkhttps://string-db.org/network/9606.ENSP00000240328T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative reg [...]
TEX14 protein networkhttps://string-db.org/network/9606.ENSP00000240361Inactive serine/threonine-protein kinase TEX14; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular br [...]
FAM117A protein networkhttps://string-db.org/network/9606.ENSP00000240364Protein FAM117A; Family with sequence similarity 117 member A.
NCAPH protein networkhttps://string-db.org/network/9606.ENSP00000240423Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...]
MND1 protein networkhttps://string-db.org/network/9606.ENSP00000240488Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both [...]
ZNF141 protein networkhttps://string-db.org/network/9606.ENSP00000240499Zinc finger protein 141; May be involved in transcriptional regulation as a repressor. Plays a role in limb development; Belongs to the krueppel C2H2-type zinc-finger protein family.
TSHZ3 protein networkhttps://string-db.org/network/9606.ENSP00000240587Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expr [...]
TAS2R8 protein networkhttps://string-db.org/network/9606.ENSP00000240615Taste receptor type 2 member 8; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
PLBD1 protein networkhttps://string-db.org/network/9606.ENSP00000240617Phospholipase B-like 1 chain A; In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phosph [...]
KLRK1 protein networkhttps://string-db.org/network/9606.ENSP00000240618NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed [...]
TAS2R10 protein networkhttps://string-db.org/network/9606.ENSP00000240619Taste receptor type 2 member 10; Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 an [...]
PYROXD1 protein networkhttps://string-db.org/network/9606.ENSP00000240651Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response. Required for normal sarcomere [...]
IAPP protein networkhttps://string-db.org/network/9606.ENSP00000240652Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calciton [...]
TAS2R7 protein networkhttps://string-db.org/network/9606.ENSP00000240687Taste receptor type 2 member 7; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...]
TAS2R9 protein networkhttps://string-db.org/network/9606.ENSP00000240691Taste receptor type 2 member 9; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...]
TFG protein networkhttps://string-db.org/network/9606.ENSP00000240851Protein TFG; Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules. Required for secretory cargo traffic from the endoplasmic reticulum to [...]
KALRN protein networkhttps://string-db.org/network/9606.ENSP00000240874Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, thr [...]
NAA50 protein networkhttps://string-db.org/network/9606.ENSP00000240922N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate th [...]
MAPK8IP1 protein networkhttps://string-db.org/network/9606.ENSP00000241014C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...]
PEX16 protein networkhttps://string-db.org/network/9606.ENSP00000241041Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and P [...]
DEPDC7 protein networkhttps://string-db.org/network/9606.ENSP00000241051DEP domain containing 7; Belongs to the DEPDC7 family.
CAT protein networkhttps://string-db.org/network/9606.ENSP00000241052Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloi [...]
GJA3 protein networkhttps://string-db.org/network/9606.ENSP00000241125Gap junction alpha-3 protein; Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells (By similarity). They are form [...]
GHSR protein networkhttps://string-db.org/network/9606.ENSP00000241256Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) ( [...]
TNFSF10 protein networkhttps://string-db.org/network/9606.ENSP00000241261Tumor necrosis factor ligand superfamily member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces a [...]
CPXM2 protein networkhttps://string-db.org/network/9606.ENSP00000241305Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; Belongs to the peptidase M14 family.
GSTM2 protein networkhttps://string-db.org/network/9606.ENSP00000241337Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
ADORA3 protein networkhttps://string-db.org/network/9606.ENSP00000241356Adenosine receptor A3; [Isoform 2]: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase ; Belongs to the G-protein coupled receptor 1 f [...]
ACVR2A protein networkhttps://string-db.org/network/9606.ENSP00000241416Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate [...]
POLK protein networkhttps://string-db.org/network/9606.ENSP00000241436DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA s [...]
FLT3 protein networkhttps://string-db.org/network/9606.ENSP00000241453Receptor-type tyrosine-protein kinase FLT3; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematop [...]
RASL11A protein networkhttps://string-db.org/network/9606.ENSP00000241463Ras-like protein family member 11A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity); Belongs to the small GTP [...]
FYTTD1 protein networkhttps://string-db.org/network/9606.ENSP00000241502UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to [...]
MYOG protein networkhttps://string-db.org/network/9606.ENSP00000241651Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential [...]
AHR protein networkhttps://string-db.org/network/9606.ENSP00000242057Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemi [...]
BBS9 protein networkhttps://string-db.org/network/9606.ENSP00000242067Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis [...]
OCM protein networkhttps://string-db.org/network/9606.ENSP00000242104Oncomodulin-1; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions; Belongs to the parvalbumin family.
EEPD1 protein networkhttps://string-db.org/network/9606.ENSP00000242108Endonuclease/exonuclease/phosphatase family domain containing 1.
WIPF3 protein networkhttps://string-db.org/network/9606.ENSP00000242140WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity); Belongs to the verprolin family.
HOXA7 protein networkhttps://string-db.org/network/9606.ENSP00000242159Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
INHBA protein networkhttps://string-db.org/network/9606.ENSP00000242208Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...]
RAMP3 protein networkhttps://string-db.org/network/9606.ENSP00000242249Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-relat [...]
MRM2 protein networkhttps://string-db.org/network/9606.ENSP00000242257rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mi [...]
TWIST1 protein networkhttps://string-db.org/network/9606.ENSP00000242261Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through phy [...]
CLTA protein networkhttps://string-db.org/network/9606.ENSP00000242285Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabili [...]
PHF24 protein networkhttps://string-db.org/network/9606.ENSP00000242315PHD finger protein 24.
ZC3HAV1 protein networkhttps://string-db.org/network/9606.ENSP00000242351Zinc finger CCCH-type antiviral protein 1; Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to [...]
AKR1D1 protein networkhttps://string-db.org/network/9606.ENSP00000242375Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one s [...]
NEUROG3 protein networkhttps://string-db.org/network/9606.ENSP00000242462Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common [...]
SRGN protein networkhttps://string-db.org/network/9606.ENSP00000242465Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tis [...]
EGR2 protein networkhttps://string-db.org/network/9606.ENSP00000242480E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Belongs to the EGR C2H2-type zinc-finger [...]
FAM149B1 protein networkhttps://string-db.org/network/9606.ENSP00000242505Protein FAM149B1; Family with sequence similarity 149 member B1.
UNG protein networkhttps://string-db.org/network/9606.ENSP00000242576Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
IFT81 protein networkhttps://string-db.org/network/9606.ENSP00000242591Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of [...]
ACADS protein networkhttps://string-db.org/network/9606.ENSP00000242592Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty a [...]
RNF11 protein networkhttps://string-db.org/network/9606.ENSP00000242719RING finger protein 11; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways [...]
BHLHE41 protein networkhttps://string-db.org/network/9606.ENSP00000242728Class E basic helix-loop-helix protein 41; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controll [...]
SSPN protein networkhttps://string-db.org/network/9606.ENSP00000242729Sarcospan; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. [...]
DDX39A protein networkhttps://string-db.org/network/9606.ENSP00000242776ATP-dependent RNA helicase DDX39A; [Isoform 1]: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily.
TRIR protein networkhttps://string-db.org/network/9606.ENSP00000242784Telomerase RNA component interacting RNase; Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end [...]
ADGRE5 protein networkhttps://string-db.org/network/9606.ENSP00000242786CD97 antigen subunit alpha; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity) [...]
ZNF442 protein networkhttps://string-db.org/network/9606.ENSP00000242804Zinc finger protein 442; May be involved in transcriptional regulation.
CCDC70 protein networkhttps://string-db.org/network/9606.ENSP00000242819Coiled-coil domain containing 70.
EBPL protein networkhttps://string-db.org/network/9606.ENSP00000242827Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands.
ATP7B protein networkhttps://string-db.org/network/9606.ENSP00000242839Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflu [...]
ZC3H13 protein networkhttps://string-db.org/network/9606.ENSP00000242848Zinc finger CCCH domain-containing protein 13; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in t [...]
NEUROD4 protein networkhttps://string-db.org/network/9606.ENSP00000242994Neurogenic differentiation factor 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina [...]
ORMDL2 protein networkhttps://string-db.org/network/9606.ENSP00000243045ORM1-like protein 2; Negative regulator of sphingolipid synthesis.
PDE1B protein networkhttps://string-db.org/network/9606.ENSP00000243052Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regul [...]
HOXC13 protein networkhttps://string-db.org/network/9606.ENSP00000243056Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair- specific genes (By similarity); Belongs to t [...]
LRP1 protein networkhttps://string-db.org/network/9606.ENSP00000243077Low-density lipoprotein receptor-related protein 1 intracellular domain; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic developmen [...]
HOXC12 protein networkhttps://string-db.org/network/9606.ENSP00000243103Homeobox protein Hox-C12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
HOXC6 protein networkhttps://string-db.org/network/9606.ENSP00000243108Homeobox protein Hox-C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
FAAH protein networkhttps://string-db.org/network/9606.ENSP00000243167Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to termin [...]
RSRP1 protein networkhttps://string-db.org/network/9606.ENSP00000243189Arginine and serine rich protein 1.
SEC61A1 protein networkhttps://string-db.org/network/9606.ENSP00000243253Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across e [...]
RAB9B protein networkhttps://string-db.org/network/9606.ENSP00000243298Ras-related protein Rab-9B; Involved in the transport of proteins between the endosomes and the trans Golgi network; Belongs to the small GTPase superfamily. Rab family.
MAGEA9 protein networkhttps://string-db.org/network/9606.ENSP00000243314Melanoma-associated antigen 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
RIF1 protein networkhttps://string-db.org/network/9606.ENSP00000243326Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end j [...]
TTC21B protein networkhttps://string-db.org/network/9606.ENSP00000243344Tetratricopeptide repeat protein 21B; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Ess [...]
NMI protein networkhttps://string-db.org/network/9606.ENSP00000243346N-myc-interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/ [...]
TNFAIP6 protein networkhttps://string-db.org/network/9606.ENSP00000243347Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.
ACVR1C protein networkhttps://string-db.org/network/9606.ENSP00000243349Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonin [...]
SLC36A1 protein networkhttps://string-db.org/network/9606.ENSP00000243389Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Beside [...]
BATF3 protein networkhttps://string-db.org/network/9606.ENSP00000243440Basic leucine zipper transcriptional factor ATF-like 3; AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Requ [...]
KCNJ2 protein networkhttps://string-db.org/network/9606.ENSP00000243457Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are char [...]
PLA2G12A protein networkhttps://string-db.org/network/9606.ENSP00000243501Group XIIA secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl [...]
SNRPA protein networkhttps://string-db.org/network/9606.ENSP00000243563U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 [...]
B9D2 protein networkhttps://string-db.org/network/9606.ENSP00000243578B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...]
C4BPB protein networkhttps://string-db.org/network/9606.ENSP00000243611C4b-binding protein beta chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. [...]
ZNF350 protein networkhttps://string-db.org/network/9606.ENSP00000243644Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'- GGGxxxCAGxxxTTT-3', within GADD45 intron 3.
RAB38 protein networkhttps://string-db.org/network/9606.ENSP00000243662Ras-related protein Rab-38; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; [...]
GPR83 protein networkhttps://string-db.org/network/9606.ENSP00000243673Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor.
HAUS3 protein networkhttps://string-db.org/network/9606.ENSP00000243706HAUS augmin-like complex subunit 3; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
CHPF protein networkhttps://string-db.org/network/9606.ENSP00000243776Chondroitin sulfate synthase 2; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...]
INHA protein networkhttps://string-db.org/network/9606.ENSP00000243786Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of divers [...]
ENKD1 protein networkhttps://string-db.org/network/9606.ENSP00000243878Enkurin domain containing 1.
ACTR5 protein networkhttps://string-db.org/network/9606.ENSP00000243903Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DN [...]
MC3R protein networkhttps://string-db.org/network/9606.ENSP00000243911Melanocortin receptor 3; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patte [...]
SYS1 protein networkhttps://string-db.org/network/9606.ENSP00000243918Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family.
PI3 protein networkhttps://string-db.org/network/9606.ENSP00000243924Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic ac [...]
WFDC3 protein networkhttps://string-db.org/network/9606.ENSP00000243938WAP four-disulfide core domain 3.
ATP5F1E protein networkhttps://string-db.org/network/9606.ENSP00000243997ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membran [...]
PLCG1 protein networkhttps://string-db.org/network/9606.ENSP000002440071-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an [...]
SRSF6 protein networkhttps://string-db.org/network/9606.ENSP00000244020Serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10 [...]
RAB22A protein networkhttps://string-db.org/network/9606.ENSP00000244040Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated end [...]
PTGIS protein networkhttps://string-db.org/network/9606.ENSP00000244043Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
SNAI1 protein networkhttps://string-db.org/network/9606.ENSP00000244050Zinc finger protein SNAI1; Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Bi [...]
MOCS3 protein networkhttps://string-db.org/network/9606.ENSP00000244051Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential durin [...]
RNF114 protein networkhttps://string-db.org/network/9606.ENSP00000244061E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes includ [...]
MAGEA10 protein networkhttps://string-db.org/network/9606.ENSP00000244096Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
PEPD protein networkhttps://string-db.org/network/9606.ENSP00000244137Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in co [...]
IL9R protein networkhttps://string-db.org/network/9606.ENSP00000244174Interleukin-9 receptor; This is a receptor for interleukin-9; Belongs to the type I cytokine receptor family. Type 4 subfamily.
MCEE protein networkhttps://string-db.org/network/9606.ENSP00000244217Methylmalonyl-CoA epimerase, mitochondrial; methylmalonyl-CoA epimerase; Belongs to the methylmalonyl-CoA epimerase family.
PAIP2B protein networkhttps://string-db.org/network/9606.ENSP00000244221Polyadenylate-binding protein-interacting protein 2B; Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail; Belongs to the PAIP2 family.
SNRNP27 protein networkhttps://string-db.org/network/9606.ENSP00000244227U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein; May play a role in mRNA splicing.
MPHOSPH10 protein networkhttps://string-db.org/network/9606.ENSP00000244230U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA process [...]
IL17C protein networkhttps://string-db.org/network/9606.ENSP00000244241Interleukin-17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibac [...]
LIPE protein networkhttps://string-db.org/network/9606.ENSP00000244289Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters [...]
IRGC protein networkhttps://string-db.org/network/9606.ENSP00000244314Interferon-inducible GTPase 5; Immunity related GTPase cinema.
LYPD3 protein networkhttps://string-db.org/network/9606.ENSP00000244333Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell- matrix interactions. May be involved in tumor progression.
CEACAM8 protein networkhttps://string-db.org/network/9606.ENSP00000244336Carcinoembryonic antigen-related cell adhesion molecule 8; Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with o [...]
RNF39 protein networkhttps://string-db.org/network/9606.ENSP00000244360RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance.
FBXO9 protein networkhttps://string-db.org/network/9606.ENSP00000244426F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradati [...]
RRP36 protein networkhttps://string-db.org/network/9606.ENSP00000244496Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family.
BTN1A1 protein networkhttps://string-db.org/network/9606.ENSP00000244513Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the api [...]
BTN3A3 protein networkhttps://string-db.org/network/9606.ENSP00000244519Butyrophilin subfamily 3 member A3; Plays a role in T-cell responses in the adaptive immune response; Belongs to the immunoglobulin superfamily. BTN/MOG family.
SNRPC protein networkhttps://string-db.org/network/9606.ENSP00000244520U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNR [...]
SLC17A1 protein networkhttps://string-db.org/network/9606.ENSP00000244527Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the [...]
H1-3 protein networkhttps://string-db.org/network/9606.ENSP00000244534Histone H1.3; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...]
H4C6 protein networkhttps://string-db.org/network/9606.ENSP00000244537Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby [...]
UNC5CL protein networkhttps://string-db.org/network/9606.ENSP00000244565UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF- kappa-B binding to its targets; Belongs to the unc-5 family.
AARS2 protein networkhttps://string-db.org/network/9606.ENSP00000244571Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the accept [...]
H1-1 protein networkhttps://string-db.org/network/9606.ENSP00000244573Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...]
ZNF391 protein networkhttps://string-db.org/network/9606.ENSP00000244576Zinc finger protein 391; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
OR2B6 protein networkhttps://string-db.org/network/9606.ENSP00000244623Olfactory receptor 2B6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
APOBEC2 protein networkhttps://string-db.org/network/9606.ENSP00000244669C->U-editing enzyme APOBEC-2; Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase [...]
TREM1 protein networkhttps://string-db.org/network/9606.ENSP00000244709Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as inc [...]
COL21A1 protein networkhttps://string-db.org/network/9606.ENSP00000244728Collagen type XXI alpha 1 chain.
SOX4 protein networkhttps://string-db.org/network/9606.ENSP00000244745Transcription factor SOX-4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif.
CPNE5 protein networkhttps://string-db.org/network/9606.ENSP00000244751Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocyt [...]
SSR1 protein networkhttps://string-db.org/network/9606.ENSP00000244763Translocon-associated protein subunit alpha; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. M [...]
ATXN1 protein networkhttps://string-db.org/network/9606.ENSP00000244769Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along wit [...]
EREG protein networkhttps://string-db.org/network/9606.ENSP00000244869Proepiregulin; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by r [...]
SCGB1D2 protein networkhttps://string-db.org/network/9606.ENSP00000244926Secretoglobin family 1D member 2; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of [...]
SCGB2A1 protein networkhttps://string-db.org/network/9606.ENSP00000244930Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.
EMC3 protein networkhttps://string-db.org/network/9606.ENSP00000245046ER membrane protein complex subunit 3.
SH3TC1 protein networkhttps://string-db.org/network/9606.ENSP00000245105SH3 domain and tetratricopeptide repeats 1.
KATNAL2 protein networkhttps://string-db.org/network/9606.ENSP00000245121Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
BBS2 protein networkhttps://string-db.org/network/9606.ENSP00000245157Bardet-Biedl syndrome 2 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...]
MT2A protein networkhttps://string-db.org/network/9606.ENSP00000245185Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoid [...]
GOT2 protein networkhttps://string-db.org/network/9606.ENSP00000245206Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabo [...]
PIWIL1 protein networkhttps://string-db.org/network/9606.ENSP00000245255Piwi-like protein 1; Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline [...]
RAP2A protein networkhttps://string-db.org/network/9606.ENSP00000245304Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors incl [...]
SLC10A2 protein networkhttps://string-db.org/network/9606.ENSP00000245312Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism; B [...]
IRF1 protein networkhttps://string-db.org/network/9606.ENSP00000245414Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-ind [...]
BMP4 protein networkhttps://string-db.org/network/9606.ENSP00000245451Bone morphogenetic protein 4; Induces cartilage and bone formation. Also acts in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to sti [...]
PTGER2 protein networkhttps://string-db.org/network/9606.ENSP00000245457Prostaglandin E2 receptor EP2 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in i [...]
SOX9 protein networkhttps://string-db.org/network/9606.ENSP00000245479Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as [...]
MRPS7 protein networkhttps://string-db.org/network/9606.ENSP00000245539Mitochondrial ribosomal protein S7.
ARMC7 protein networkhttps://string-db.org/network/9606.ENSP00000245543Armadillo repeat containing 7.
NUP85 protein networkhttps://string-db.org/network/9606.ENSP00000245544Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex play [...]
NT5C protein networkhttps://string-db.org/network/9606.ENSP000002455525'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and l [...]
MSTO1 protein networkhttps://string-db.org/network/9606.ENSP00000245564Protein misato homolog 1; Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation.
MBOAT7 protein networkhttps://string-db.org/network/9606.ENSP00000245615Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion [...]
LILRB3 protein networkhttps://string-db.org/network/9606.ENSP00000245620Leukocyte immunoglobulin-like receptor subfamily B member 3; May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the [...]
SLC35F5 protein networkhttps://string-db.org/network/9606.ENSP00000245680Solute carrier family 35 member F5; Putative solute transporter; Belongs to the SLC35F solute transporter family.
INSIG2 protein networkhttps://string-db.org/network/9606.ENSP00000245787Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding protein [...]
PSD4 protein networkhttps://string-db.org/network/9606.ENSP00000245796PH and SEC7 domain-containing protein 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II- containing vesicles along the [...]
PSPN protein networkhttps://string-db.org/network/9606.ENSP00000245810Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons.
ALKBH7 protein networkhttps://string-db.org/network/9606.ENSP00000245812Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due [...]
CLPP protein networkhttps://string-db.org/network/9606.ENSP00000245816ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase acti [...]
TNFSF9 protein networkhttps://string-db.org/network/9606.ENSP00000245817Tumor necrosis factor ligand superfamily member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation- induced cell dea [...]
THOC2 protein networkhttps://string-db.org/network/9606.ENSP00000245838THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcript [...]
C3 protein networkhttps://string-db.org/network/9606.ENSP00000245907Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternati [...]
SH2D3A protein networkhttps://string-db.org/network/9606.ENSP00000245908SH2 domain-containing protein 3A; May play a role in JNK activation.
FOSB protein networkhttps://string-db.org/network/9606.ENSP00000245919Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity.
RTN2 protein networkhttps://string-db.org/network/9606.ENSP00000245923Reticulon-2; Reticulon 2.
VASP protein networkhttps://string-db.org/network/9606.ENSP00000245932Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidanc [...]
SYMPK protein networkhttps://string-db.org/network/9606.ENSP00000245934Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might n [...]
CFAP61 protein networkhttps://string-db.org/network/9606.ENSP00000245957Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes.
CDC25B protein networkhttps://string-db.org/network/9606.ENSP00000245960M-phase inducer phosphatase 2; Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and absci [...]
GNRH2 protein networkhttps://string-db.org/network/9606.ENSP00000245983GnRH-associated peptide 2; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family.
CD93 protein networkhttps://string-db.org/network/9606.ENSP00000246006Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement [...]
CST8 protein networkhttps://string-db.org/network/9606.ENSP00000246012Cystatin-8; Performs a specialized role during sperm development and maturation.
TMX4 protein networkhttps://string-db.org/network/9606.ENSP00000246024Thioredoxin related transmembrane protein 4.
MKKS protein networkhttps://string-db.org/network/9606.ENSP00000246062McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a compl [...]
DSTN protein networkhttps://string-db.org/network/9606.ENSP00000246069Destrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
LAMP5 protein networkhttps://string-db.org/network/9606.ENSP00000246070Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
SNRPB2 protein networkhttps://string-db.org/network/9606.ENSP00000246071U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA.
TCF15 protein networkhttps://string-db.org/network/9606.ENSP00000246080Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
OTOR protein networkhttps://string-db.org/network/9606.ENSP00000246081Otoraplin; Belongs to the MIA/OTOR family.
DEFB129 protein networkhttps://string-db.org/network/9606.ENSP00000246105Beta-defensin 129; Has antibacterial activity.
TLE6 protein networkhttps://string-db.org/network/9606.ENSP00000246112Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to t [...]
S1PR4 protein networkhttps://string-db.org/network/9606.ENSP00000246115Sphingosine 1-phosphate receptor 4; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of [...]
NCLN protein networkhttps://string-db.org/network/9606.ENSP00000246117Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family.
PITHD1 protein networkhttps://string-db.org/network/9606.ENSP00000246151PITH domain-containing protein 1; Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by [...]
FNTB protein networkhttps://string-db.org/network/9606.ENSP00000246166Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth p [...]
MMP24 protein networkhttps://string-db.org/network/9606.ENSP00000246186Processed matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved i [...]
NECAB3 protein networkhttps://string-db.org/network/9606.ENSP00000246190N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of [...]
RALY protein networkhttps://string-db.org/network/9606.ENSP00000246194RNA-binding protein Raly; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid- responsive non-coding RNA LeXis and is requ [...]
PLAGL2 protein networkhttps://string-db.org/network/9606.ENSP00000246229Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Belongs to the krueppel C2H2-type zinc-finger protein family.
UROD protein networkhttps://string-db.org/network/9606.ENSP00000246337Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
SLURP1 protein networkhttps://string-db.org/network/9606.ENSP00000246515Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity [...]
LRFN3 protein networkhttps://string-db.org/network/9606.ENSP00000246529Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgr [...]
IGFLR1 protein networkhttps://string-db.org/network/9606.ENSP00000246532IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2.
PDCD2L protein networkhttps://string-db.org/network/9606.ENSP00000246535Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase.
UBA2 protein networkhttps://string-db.org/network/9606.ENSP00000246548SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of [...]
HCST protein networkhttps://string-db.org/network/9606.ENSP00000246551Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a majo [...]
FFAR1 protein networkhttps://string-db.org/network/9606.ENSP00000246553Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding incr [...]
KRT13 protein networkhttps://string-db.org/network/9606.ENSP00000246635Keratin, type I cytoskeletal 13; Keratin 13.
KRT38 protein networkhttps://string-db.org/network/9606.ENSP00000246646Keratin, type I cuticular Ha8; Keratin 38; Belongs to the intermediate filament family.
CCR7 protein networkhttps://string-db.org/network/9606.ENSP00000246657C-C chemokine receptor type 7; Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions; Belongs to the G-protein coupled recepto [...]
KRT9 protein networkhttps://string-db.org/network/9606.ENSP00000246662Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Play [...]
NR1D1 protein networkhttps://string-db.org/network/9606.ENSP00000246672Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex tr [...]
ARL2 protein networkhttps://string-db.org/network/9606.ENSP00000246747ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleoti [...]
RRAS protein networkhttps://string-db.org/network/9606.ENSP00000246792Ras-related protein R-Ras; Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
PRRG2 protein networkhttps://string-db.org/network/9606.ENSP00000246794Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain 2.
TSKS protein networkhttps://string-db.org/network/9606.ENSP00000246801Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development.
NOP53 protein networkhttps://string-db.org/network/9606.ENSP00000246802Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may al [...]
FLRT1 protein networkhttps://string-db.org/network/9606.ENSP00000246841Leucine-rich repeat transmembrane protein FLRT1; Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FG [...]
SBDS protein networkhttps://string-db.org/network/9606.ENSP00000246868Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in t [...]
CSN1S1 protein networkhttps://string-db.org/network/9606.ENSP00000246891Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family.
STATH protein networkhttps://string-db.org/network/9606.ENSP00000246895Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation [...]
MLX protein networkhttps://string-db.org/network/9606.ENSP00000246912Max-like protein X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TC [...]
WNK4 protein networkhttps://string-db.org/network/9606.ENSP00000246914Serine/threonine-protein kinase WNK4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an ac [...]
TRAP1 protein networkhttps://string-db.org/network/9606.ENSP00000246957Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial compl [...]
SUGP1 protein networkhttps://string-db.org/network/9606.ENSP00000247001SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing.
DDX49 protein networkhttps://string-db.org/network/9606.ENSP00000247003Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
GDF1 protein networkhttps://string-db.org/network/9606.ENSP00000247005Embryonic growth/differentiation factor 1; May mediate cell differentiation events during embryonic development.
SDF2 protein networkhttps://string-db.org/network/9606.ENSP00000247020Stromal cell derived factor 2.
NSRP1 protein networkhttps://string-db.org/network/9606.ENSP00000247026Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
CFP protein networkhttps://string-db.org/network/9606.ENSP00000247153Properdin; A positive regulator of the alternate pathway (AP) of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Comple [...]
ATG14 protein networkhttps://string-db.org/network/9606.ENSP00000247178Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a r [...]
DLGAP5 protein networkhttps://string-db.org/network/9606.ENSP00000247191Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key [...]
L3HYPDH protein networkhttps://string-db.org/network/9606.ENSP00000247194Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline fro [...]
TBPL2 protein networkhttps://string-db.org/network/9606.ENSP00000247219TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at [...]
SGPP1 protein networkhttps://string-db.org/network/9606.ENSP00000247225Sphingosine-1-phosphate phosphatase 1; Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phos [...]
PLEKHG3 protein networkhttps://string-db.org/network/9606.ENSP00000247226Pleckstrin homology and RhoGEF domain containing G3.
EVI2A protein networkhttps://string-db.org/network/9606.ENSP00000247270Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor.
OMG protein networkhttps://string-db.org/network/9606.ENSP00000247271Oligodendrocyte-myelin glycoprotein; Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
CTAG2 protein networkhttps://string-db.org/network/9606.ENSP00000247306Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family.
CANX protein networkhttps://string-db.org/network/9606.ENSP00000247461Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER [...]
PYCARD protein networkhttps://string-db.org/network/9606.ENSP00000247470Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also [...]
PHPT1 protein networkhttps://string-db.org/network/9606.ENSP0000024766514 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity. Belongs to the janus family.
TRAF2 protein networkhttps://string-db.org/network/9606.ENSP00000247668TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switch [...]
ABHD8 protein networkhttps://string-db.org/network/9606.ENSP00000247706Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily.
HELB protein networkhttps://string-db.org/network/9606.ENSP00000247815DNA helicase B; 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit [...]
YEATS4 protein networkhttps://string-db.org/network/9606.ENSP00000247843YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...]
TAS2R3 protein networkhttps://string-db.org/network/9606.ENSP00000247879Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...]
TAS2R4 protein networkhttps://string-db.org/network/9606.ENSP00000247881Taste receptor type 2 member 4; Gustducin-coupled receptor for denatonium and N(6)-propyl-2- thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestina [...]
TAS2R5 protein networkhttps://string-db.org/network/9606.ENSP00000247883Taste receptor type 2 member 5; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
ZNF777 protein networkhttps://string-db.org/network/9606.ENSP00000247930Zinc finger protein 777; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
IDUA protein networkhttps://string-db.org/network/9606.ENSP00000247933alpha-L-iduronidase.
ZNF317 protein networkhttps://string-db.org/network/9606.ENSP00000247956Zinc finger protein 317; May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation.
PIN1 protein networkhttps://string-db.org/network/9606.ENSP00000247970Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By ind [...]
FBXL12 protein networkhttps://string-db.org/network/9606.ENSP00000247977F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of [...]
KIF17 protein networkhttps://string-db.org/network/9606.ENSP00000247986Kinesin-like protein KIF17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin famil [...]
PLA2G2C protein networkhttps://string-db.org/network/9606.ENSP00000247992Putative inactive group IIC secretory phospholipase A2; Inactive phospholipase.
KLF2 protein networkhttps://string-db.org/network/9606.ENSP00000248071Krueppel-like factor 2; Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in tra [...]
OR7C2 protein networkhttps://string-db.org/network/9606.ENSP00000248072Olfactory receptor 7C2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
F2RL3 protein networkhttps://string-db.org/network/9606.ENSP00000248076Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to t [...]
HCFC1R1 protein networkhttps://string-db.org/network/9606.ENSP00000248089Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated e [...]
JPT2 protein networkhttps://string-db.org/network/9606.ENSP00000248098Jupiter microtubule associated homolog 2; Belongs to the JUPITER family.
GFER protein networkhttps://string-db.org/network/9606.ENSP00000248114FAD-linked sulfhydryl oxidase ALR; [Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond format [...]
SYNGR3 protein networkhttps://string-db.org/network/9606.ENSP00000248121Synaptogyrin-3; May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from [...]
RAB40C protein networkhttps://string-db.org/network/9606.ENSP00000248139Ras-related protein Rab-40C; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...]
GNG13 protein networkhttps://string-db.org/network/9606.ENSP00000248150Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...]
ZNF10 protein networkhttps://string-db.org/network/9606.ENSP00000248211Zinc finger protein 10; May be involved in transcriptional regulation.
TICAM1 protein networkhttps://string-db.org/network/9606.ENSP00000248244TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF- kappa-B and interferon-regula [...]
MON1B protein networkhttps://string-db.org/network/9606.ENSP00000248248MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family.
METTL25 protein networkhttps://string-db.org/network/9606.ENSP00000248306Methyltransferase-like protein 25; Putative methyltransferase.
EIF3K protein networkhttps://string-db.org/network/9606.ENSP00000248342Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
OR1E2 protein networkhttps://string-db.org/network/9606.ENSP00000248384Olfactory receptor 1E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TUBA4A protein networkhttps://string-db.org/network/9606.ENSP00000248437Tubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...]
VIL1 protein networkhttps://string-db.org/network/9606.ENSP00000248444Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament [...]
HSPB1 protein networkhttps://string-db.org/network/9606.ENSP00000248553Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistan [...]
GNG11 protein networkhttps://string-db.org/network/9606.ENSP00000248564Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...]
GNGT1 protein networkhttps://string-db.org/network/9606.ENSP00000248572Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. Th [...]
PTPN12 protein networkhttps://string-db.org/network/9606.ENSP00000248594Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERB [...]
FGL2 protein networkhttps://string-db.org/network/9606.ENSP00000248598Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites.
STYXL1 protein networkhttps://string-db.org/network/9606.ENSP00000248600Serine/threonine/tyrosine-interacting-like protein 1; Catalytically inactive phosphatase. By binding to G3BP1, inhibits the formation of G3BP1- induced stress granules. Does not act by protecting [...]
PEX1 protein networkhttps://string-db.org/network/9606.ENSP00000248633Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase co [...]
MTERF1 protein networkhttps://string-db.org/network/9606.ENSP00000248643Transcription termination factor 1, mitochondrial; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of [...]
LRFN1 protein networkhttps://string-db.org/network/9606.ENSP00000248668Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Ind [...]
RASL11B protein networkhttps://string-db.org/network/9606.ENSP00000248706Ras-like protein family member 11B; RAS like family 11 member B.
TUBGCP6 protein networkhttps://string-db.org/network/9606.ENSP00000248846Gamma-tubulin complex component 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
DGCR6L protein networkhttps://string-db.org/network/9606.ENSP00000248879Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family.
CYTH4 protein networkhttps://string-db.org/network/9606.ENSP00000248901Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
GGT1 protein networkhttps://string-db.org/network/9606.ENSP00000248923Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism o [...]
SGSM3 protein networkhttps://string-db.org/network/9606.ENSP00000248929Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells.
SEZ6L protein networkhttps://string-db.org/network/9606.ENSP00000248933Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons.
VPREB3 protein networkhttps://string-db.org/network/9606.ENSP00000248948Pre-B lymphocyte protein 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells; Belongs to the immunoglobulin superfamily.
SDF2L1 protein networkhttps://string-db.org/network/9606.ENSP00000248958Stromal cell derived factor 2 like 1.
YWHAH protein networkhttps://string-db.org/network/9606.ENSP0000024897514-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognitio [...]
RFPL3 protein networkhttps://string-db.org/network/9606.ENSP00000249007Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex.
CDC42EP1 protein networkhttps://string-db.org/network/9606.ENSP00000249014Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts.
MCHR1 protein networkhttps://string-db.org/network/9606.ENSP00000249016Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrol [...]
GALR3 protein networkhttps://string-db.org/network/9606.ENSP00000249041Galanin receptor type 3; Receptor for the hormone galanin. Receptor for the hormone spexin-1.
APOL5 protein networkhttps://string-db.org/network/9606.ENSP00000249044Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
CCDC117 protein networkhttps://string-db.org/network/9606.ENSP00000249064Coiled-coil domain containing 117.
APOL2 protein networkhttps://string-db.org/network/9606.ENSP00000249066Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
RAC2 protein networkhttps://string-db.org/network/9606.ENSP00000249071Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of ef [...]
LIF protein networkhttps://string-db.org/network/9606.ENSP00000249075Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid [...]
PMPCB protein networkhttps://string-db.org/network/9606.ENSP00000249269Mitochondrial-processing peptidase subunit beta; Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors [...]
TAS2R16 protein networkhttps://string-db.org/network/9606.ENSP00000249284Taste receptor type 2 member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calci [...]
LSM8 protein networkhttps://string-db.org/network/9606.ENSP00000249299U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
VGF protein networkhttps://string-db.org/network/9606.ENSP00000249330Neuroendocrine regulatory peptide-1; [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-spe [...]
STRIP2 protein networkhttps://string-db.org/network/9606.ENSP00000249344Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the STRIP family.
DNAJB9 protein networkhttps://string-db.org/network/9606.ENSP00000249356DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-contai [...]
LRRC4 protein networkhttps://string-db.org/network/9606.ENSP00000249363Leucine-rich repeat-containing protein 4; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pa [...]
SMO protein networkhttps://string-db.org/network/9606.ENSP00000249373Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its recepto [...]
OPN1SW protein networkhttps://string-db.org/network/9606.ENSP00000249389Short-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal (Probable). Required fo [...]
SIRT2 protein networkhttps://string-db.org/network/9606.ENSP00000249396NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcr [...]
MTX2 protein networkhttps://string-db.org/network/9606.ENSP00000249442Metaxin-2; Involved in transport of proteins into the mitochondrion.
HOXD9 protein networkhttps://string-db.org/network/9606.ENSP00000249499Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
HOXD10 protein networkhttps://string-db.org/network/9606.ENSP00000249501Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
HOXD11 protein networkhttps://string-db.org/network/9606.ENSP00000249504Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
SNAP23 protein networkhttps://string-db.org/network/9606.ENSP00000249647Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; [...]
TMOD2 protein networkhttps://string-db.org/network/9606.ENSP00000249700Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...]
DLL4 protein networkhttps://string-db.org/network/9606.ENSP00000249749Delta-like protein 4; Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migra [...]
ALDH1A2 protein networkhttps://string-db.org/network/9606.ENSP00000249750Retinal dehydrogenase 2; Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but [...]
KNSTRN protein networkhttps://string-db.org/network/9606.ENSP00000249776Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase tra [...]
CLN6 protein networkhttps://string-db.org/network/9606.ENSP00000249806CLN6 transmembrane ER protein.
ISLR protein networkhttps://string-db.org/network/9606.ENSP00000249842Immunoglobulin superfamily containing leucine rich repeat.
THAP10 protein networkhttps://string-db.org/network/9606.ENSP00000249861THAP domain containing 10.
ACKR4 protein networkhttps://string-db.org/network/9606.ENSP00000249887Atypical chemokine receptor 4; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...]
MBD4 protein networkhttps://string-db.org/network/9606.ENSP00000249910Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethyl [...]
COPB1 protein networkhttps://string-db.org/network/9606.ENSP00000249923Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynth [...]
MYOD1 protein networkhttps://string-db.org/network/9606.ENSP00000250003Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 an [...]
TPH1 protein networkhttps://string-db.org/network/9606.ENSP00000250018Tryptophan hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
E2F8 protein networkhttps://string-db.org/network/9606.ENSP00000250024Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription [...]
PIMREG protein networkhttps://string-db.org/network/9606.ENSP00000250056Protein PIMREG; During mitosis, may play a role in the control of metaphase- to-anaphase transition.
ZNF232 protein networkhttps://string-db.org/network/9606.ENSP00000250076Zinc finger protein 232; May be involved in transcriptional regulation.
CD68 protein networkhttps://string-db.org/network/9606.ENSP00000250092Macrosialin; Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tiss [...]
TXNDC17 protein networkhttps://string-db.org/network/9606.ENSP00000250101Thioredoxin domain-containing protein 17; Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze [...]
ATP1B2 protein networkhttps://string-db.org/network/9606.ENSP00000250111Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...]
FXR2 protein networkhttps://string-db.org/network/9606.ENSP00000250113Fragile X mental retardation syndrome-related protein 2; RNA-binding protein; Belongs to the FMR1 family.
MPDU1 protein networkhttps://string-db.org/network/9606.ENSP00000250124Mannose-P-dolichol utilization defect 1 protein; Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI ancho [...]
CCN4 protein networkhttps://string-db.org/network/9606.ENSP00000250160CCN family member 4; Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of A [...]
QTRT1 protein networkhttps://string-db.org/network/9606.ENSP00000250237Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at p [...]
ERI1 protein networkhttps://string-db.org/network/9606.ENSP000002502633'-5' exoribonuclease 1; RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and [...]
CLEC11A protein networkhttps://string-db.org/network/9606.ENSP00000250340C-type lectin domain family 11 member A; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult [...]
KLK12 protein networkhttps://string-db.org/network/9606.ENSP00000250351Kallikrein-12; Kallikrein related peptidase 12; Belongs to the peptidase S1 family. Kallikrein subfamily.
CMA1 protein networkhttps://string-db.org/network/9606.ENSP00000250378Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
BCL2L2 protein networkhttps://string-db.org/network/9606.ENSP00000250405Bcl-2-like protein 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
PARP2 protein networkhttps://string-db.org/network/9606.ENSP00000250416Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosy [...]
FOXA1 protein networkhttps://string-db.org/network/9606.ENSP00000250448Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differenti [...]
EAPP protein networkhttps://string-db.org/network/9606.ENSP00000250454E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry [...]
EGLN3 protein networkhttps://string-db.org/network/9606.ENSP00000250457Egl nine homolog 3; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...]
NEDD8 protein networkhttps://string-db.org/network/9606.ENSP00000250495NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 [...]
DAD1 protein networkhttps://string-db.org/network/9606.ENSP00000250498Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3 [...]
CDO1 protein networkhttps://string-db.org/network/9606.ENSP00000250535Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of c [...]
RAP1B protein networkhttps://string-db.org/network/9606.ENSP00000250559Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct [...]
AANAT protein networkhttps://string-db.org/network/9606.ENSP00000250615Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in [...]
ARHGEF6 protein networkhttps://string-db.org/network/9606.ENSP00000250617Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF).
ART1 protein networkhttps://string-db.org/network/9606.ENSP00000250693GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R.
CHRNA10 protein networkhttps://string-db.org/network/9606.ENSP00000250699Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation th [...]
RPS4Y1 protein networkhttps://string-db.org/network/9606.ENSP00000250784Ribosomal protein S4 Y-linked 1; Belongs to the eukaryotic ribosomal protein eS4 family.
VCY1B protein networkhttps://string-db.org/network/9606.ENSP00000250823Testis-specific basic protein Y 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family.
VCY protein networkhttps://string-db.org/network/9606.ENSP00000250825Variable charge Y-linked.
RBMY1J protein networkhttps://string-db.org/network/9606.ENSP00000250831RNA-binding motif protein, Y chromosome, family 1 member F/J; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA s [...]
DAZL protein networkhttps://string-db.org/network/9606.ENSP00000250863Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRN [...]
MKNK2 protein networkhttps://string-db.org/network/9606.ENSP00000250896MAP kinase-interacting serine/threonine-protein kinase 2; Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress [...]
KLF16 protein networkhttps://string-db.org/network/9606.ENSP00000250916Krueppel-like factor 16; Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity); Belongs [...]
ABHD17A protein networkhttps://string-db.org/network/9606.ENSP00000250974Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity [...]
SALL1 protein networkhttps://string-db.org/network/9606.ENSP00000251020Sal-like protein 1; Transcriptional repressor involved in organogenesis.
ZC3H14 protein networkhttps://string-db.org/network/9606.ENSP00000251038Zinc finger CCCH domain-containing protein 14; Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
LMAN1 protein networkhttps://string-db.org/network/9606.ENSP00000251047Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of [...]
ANGEL1 protein networkhttps://string-db.org/network/9606.ENSP00000251089Angel homolog 1; Belongs to the CCR4/nocturin family.
CNGB1 protein networkhttps://string-db.org/network/9606.ENSP00000251102Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal tran [...]
CDADC1 protein networkhttps://string-db.org/network/9606.ENSP00000251108Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family.
ZFYVE26 protein networkhttps://string-db.org/network/9606.ENSP00000251119Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and act [...]
NALCN protein networkhttps://string-db.org/network/9606.ENSP00000251127Sodium leak channel non-selective protein; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and [...]
VPS35L protein networkhttps://string-db.org/network/9606.ENSP00000251143VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and es [...]
DOCK7 protein networkhttps://string-db.org/network/9606.ENSP00000251157Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a [...]
CORO7 protein networkhttps://string-db.org/network/9606.ENSP00000251166Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interact [...]
SEC14L5 protein networkhttps://string-db.org/network/9606.ENSP00000251170SEC14-like protein 5; SEC14 like lipid binding 5.
PBX4 protein networkhttps://string-db.org/network/9606.ENSP00000251203Pre-B-cell leukemia transcription factor 4; PBX homeobox 4; Belongs to the TALE/PBX homeobox family.
DHX40 protein networkhttps://string-db.org/network/9606.ENSP00000251241Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily.
DTWD1 protein networkhttps://string-db.org/network/9606.ENSP00000251250DTW domain containing 1; Belongs to the DTW family.
MEGF8 protein networkhttps://string-db.org/network/9606.ENSP00000251268Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling.
ZNF221 protein networkhttps://string-db.org/network/9606.ENSP00000251269Zinc finger protein 221; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HCN2 protein networkhttps://string-db.org/network/9606.ENSP00000251287Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to [...]
IGSF21 protein networkhttps://string-db.org/network/9606.ENSP00000251296Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.
SLX1A protein networkhttps://string-db.org/network/9606.ENSP00000251303Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombinati [...]
GNAT2 protein networkhttps://string-db.org/network/9606.ENSP00000251337Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Tra [...]
CERS4 protein networkhttps://string-db.org/network/9606.ENSP00000251363Ceramide synthase 4; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl [...]
LILRA1 protein networkhttps://string-db.org/network/9606.ENSP00000251372Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens.
TUBG2 protein networkhttps://string-db.org/network/9606.ENSP00000251412Tubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentrio [...]
TUBG1 protein networkhttps://string-db.org/network/9606.ENSP00000251413Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentrio [...]
MAST1 protein networkhttps://string-db.org/network/9606.ENSP00000251472Microtubule-associated serine/threonine-protein kinase 1; Microtubule-associated protein essential for correct brain development. Appears to link the dystrophin/utrophin network with microtubule [...]
NCAPG protein networkhttps://string-db.org/network/9606.ENSP00000251496Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...]
RABGAP1L protein networkhttps://string-db.org/network/9606.ENSP00000251507Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP. Plays a role in endocytosis an [...]
ALOX12 protein networkhttps://string-db.org/network/9606.ENSP00000251535Arachidonate 12-lipoxygenase, 12S-type; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipi [...]
UGT2A3 protein networkhttps://string-db.org/network/9606.ENSP00000251566UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...]
ADAMTS2 protein networkhttps://string-db.org/network/9606.ENSP00000251582A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By [...]
CIAO3 protein networkhttps://string-db.org/network/9606.ENSP00000251588Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster in [...]
HBA2 protein networkhttps://string-db.org/network/9606.ENSP00000251595Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.
TRNT1 protein networkhttps://string-db.org/network/9606.ENSP00000251607CCA tRNA nucleotidyltransferase 1, mitochondrial; [Isoform 1]: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, usi [...]
DHX29 protein networkhttps://string-db.org/network/9606.ENSP00000251636ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher [...]
DHX58 protein networkhttps://string-db.org/network/9606.ENSP00000251642Probable ATP-dependent RNA helicase DHX58; Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required [...]
KRT12 protein networkhttps://string-db.org/network/9606.ENSP00000251643Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (B [...]
KRT31 protein networkhttps://string-db.org/network/9606.ENSP00000251645Keratin, type I cuticular Ha1; Keratin 31.
KRT33B protein networkhttps://string-db.org/network/9606.ENSP00000251646Keratin, type I cuticular Ha3-II; Keratin 33B; Belongs to the intermediate filament family.
ARFGEF3 protein networkhttps://string-db.org/network/9606.ENSP00000251691Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic [...]
SLC4A5 protein networkhttps://string-db.org/network/9606.ENSP00000251768Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a hous [...]
SNX4 protein networkhttps://string-db.org/network/9606.ENSP00000251775Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradati [...]
RRM2B protein networkhttps://string-db.org/network/9606.ENSP00000251810Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in c [...]
TDRD1 protein networkhttps://string-db.org/network/9606.ENSP00000251864Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for t [...]
MED17 protein networkhttps://string-db.org/network/9606.ENSP00000251871Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
SCML2 protein networkhttps://string-db.org/network/9606.ENSP00000251900Sex comb on midleg-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...]
NXPE1 protein networkhttps://string-db.org/network/9606.ENSP00000251921NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family.
TSG101 protein networkhttps://string-db.org/network/9606.ENSP00000251968Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of end [...]
KIAA0930 protein networkhttps://string-db.org/network/9606.ENSP00000251993Uncharacterized protein KIAA0930; KIAA0930.
DHX35 protein networkhttps://string-db.org/network/9606.ENSP00000252011Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily.
TRPC4AP protein networkhttps://string-db.org/network/9606.ENSP00000252015Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX [...]
C20orf194 protein networkhttps://string-db.org/network/9606.ENSP00000252032Uncharacterized protein C20orf194; May act as an effector for ARL3.
FKBP6 protein networkhttps://string-db.org/network/9606.ENSP00000252037Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germli [...]
CUL9 protein networkhttps://string-db.org/network/9606.ENSP00000252050Cullin-9; Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynami [...]
ACTR3C protein networkhttps://string-db.org/network/9606.ENSP00000252071Actin-related protein 3C; May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.
PCDHGA12 protein networkhttps://string-db.org/network/9606.ENSP00000252085Protocadherin gamma-A12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHGC5 protein networkhttps://string-db.org/network/9606.ENSP00000252087Protocadherin gamma-C5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
TMCO6 protein networkhttps://string-db.org/network/9606.ENSP00000252100Transmembrane and coiled-coil domains 6.
NDUFA2 protein networkhttps://string-db.org/network/9606.ENSP00000252102NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
ESS2 protein networkhttps://string-db.org/network/9606.ENSP00000252137Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing.
MICB protein networkhttps://string-db.org/network/9606.ENSP00000252229MHC class I polypeptide-related sequence B; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NK [...]
KRT5 protein networkhttps://string-db.org/network/9606.ENSP00000252242Keratin, type II cytoskeletal 5; Keratin 5; Belongs to the intermediate filament family.
KRT1 protein networkhttps://string-db.org/network/9606.ENSP00000252244Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In comple [...]
KRT75 protein networkhttps://string-db.org/network/9606.ENSP00000252245Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.
KRT6C protein networkhttps://string-db.org/network/9606.ENSP00000252250Keratin, type II cytoskeletal 6C; Keratin 6C; Belongs to the intermediate filament family.
KRT6B protein networkhttps://string-db.org/network/9606.ENSP00000252252Keratin, type II cytoskeletal 6B; Keratin 6B; Belongs to the intermediate filament family.
DPF2 protein networkhttps://string-db.org/network/9606.ENSP00000252268Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenit [...]
GALNT8 protein networkhttps://string-db.org/network/9606.ENSP00000252318Probable polypeptide N-acetylgalactosaminyltransferase 8; Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to [...]
KCNA5 protein networkhttps://string-db.org/network/9606.ENSP00000252321Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective [...]
FAM155B protein networkhttps://string-db.org/network/9606.ENSP00000252338Transmembrane protein FAM155B; Family with sequence similarity 155 member B.
CNN1 protein networkhttps://string-db.org/network/9606.ENSP00000252456Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...]
EXOC3L2 protein networkhttps://string-db.org/network/9606.ENSP00000252482Exocyst complex component 3 like 2; Belongs to the SEC6 family.
NECTIN2 protein networkhttps://string-db.org/network/9606.ENSP00000252483Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell prolife [...]
APOE protein networkhttps://string-db.org/network/9606.ENSP00000252486Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstiti [...]
ALLC protein networkhttps://string-db.org/network/9606.ENSP00000252505Probable allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
GADD45G protein networkhttps://string-db.org/network/9606.ENSP00000252506Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 [...]
XPO7 protein networkhttps://string-db.org/network/9606.ENSP00000252512Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. [...]
FAM98C protein networkhttps://string-db.org/network/9606.ENSP00000252530Protein FAM98C; Family with sequence similarity 98 member C.
SAFB2 protein networkhttps://string-db.org/network/9606.ENSP00000252542Scaffold attachment factor B2; Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
NCAN protein networkhttps://string-db.org/network/9606.ENSP00000252575Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; bin [...]
PLVAP protein networkhttps://string-db.org/network/9606.ENSP00000252590Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the forma [...]
BST2 protein networkhttps://string-db.org/network/9606.ENSP00000252593Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to t [...]
SLC27A1 protein networkhttps://string-db.org/network/9606.ENSP00000252595Long-chain fatty acid transport protein 1; Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an ac [...]
USHBP1 protein networkhttps://string-db.org/network/9606.ENSP00000252597Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1.
COLGALT1 protein networkhttps://string-db.org/network/9606.ENSP00000252599Procollagen galactosyltransferase 1; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the fo [...]
MRPL34 protein networkhttps://string-db.org/network/9606.ENSP00000252602Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family.
PGLS protein networkhttps://string-db.org/network/9606.ENSP000002526036-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
LSM7 protein networkhttps://string-db.org/network/9606.ENSP00000252622U6 snRNA-associated Sm-like protein LSm7; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
RSPH3 protein networkhttps://string-db.org/network/9606.ENSP00000252655Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK an [...]
MLLT1 protein networkhttps://string-db.org/network/9606.ENSP00000252674Protein ENL; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymera [...]
BMP15 protein networkhttps://string-db.org/network/9606.ENSP00000252677Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
ACTN4 protein networkhttps://string-db.org/network/9606.ENSP00000252699Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular tra [...]
NDUFA10 protein networkhttps://string-db.org/network/9606.ENSP00000252711NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed no [...]
EPO protein networkhttps://string-db.org/network/9606.ENSP00000252723Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR lea [...]
CACNG6 protein networkhttps://string-db.org/network/9606.ENSP00000252729Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit; Belongs to the PMP-22/EMP/MP20 family. CACNG sub [...]
ZSWIM6 protein networkhttps://string-db.org/network/9606.ENSP00000252744Zinc finger SWIM domain-containing protein 6; involved in nervous system development, important for striatal morphology and motor regulation.
ZNF764 protein networkhttps://string-db.org/network/9606.ENSP00000252797Zinc finger protein 764; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PXDN protein networkhttps://string-db.org/network/9606.ENSP00000252804Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular ma [...]
GDF15 protein networkhttps://string-db.org/network/9606.ENSP00000252809Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL- [...]
JUND protein networkhttps://string-db.org/network/9606.ENSP00000252818Transcription factor jun-D; Transcription factor binding AP-1 sites.
HRC protein networkhttps://string-db.org/network/9606.ENSP00000252825Sarcoplasmic reticulum histidine-rich calcium-binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.
TRPM4 protein networkhttps://string-db.org/network/9606.ENSP00000252826Transient receptor potential cation channel subfamily M member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in [...]
OR11H1 protein networkhttps://string-db.org/network/9606.ENSP00000252835Olfactory receptor 11H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF557 protein networkhttps://string-db.org/network/9606.ENSP00000252840Zinc finger protein 557; May be involved in transcriptional regulation.
NUMBL protein networkhttps://string-db.org/network/9606.ENSP00000252891Numb-like protein; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing [...]
ATXN10 protein networkhttps://string-db.org/network/9606.ENSP00000252934Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycos [...]
CALY protein networkhttps://string-db.org/network/9606.ENSP00000252939Neuron-specific vesicular protein calcyon; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.
HBZ protein networkhttps://string-db.org/network/9606.ENSP00000252951Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
MNX1 protein networkhttps://string-db.org/network/9606.ENSP00000252971Motor neuron and pancreas homeobox protein 1; Putative transcription factor involved in pancreas development and function.
ZNF337 protein networkhttps://string-db.org/network/9606.ENSP00000252979Zinc finger protein 337; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CEP85 protein networkhttps://string-db.org/network/9606.ENSP00000252992Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity. Belon [...]
TAF4 protein networkhttps://string-db.org/network/9606.ENSP00000252996Transcription initiation factor TFIID subunit 4; Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repres [...]
GATA5 protein networkhttps://string-db.org/network/9606.ENSP00000252997Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity [...]
RBBP8NL protein networkhttps://string-db.org/network/9606.ENSP00000252998RBBP8 N-terminal-like protein; RBBP8 N-terminal like.
LAMA5 protein networkhttps://string-db.org/network/9606.ENSP00000252999Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
PRDM12 protein networkhttps://string-db.org/network/9606.ENSP00000253008PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation.
UBE2M protein networkhttps://string-db.org/network/9606.ENSP00000253023NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E [...]
TRIM28 protein networkhttps://string-db.org/network/9606.ENSP00000253024Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome [...]
YIPF2 protein networkhttps://string-db.org/network/9606.ENSP00000253031Protein YIPF2; Yip1 domain family member 2.
EIF2S3 protein networkhttps://string-db.org/network/9606.ENSP00000253039Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a [...]
TMEM160 protein networkhttps://string-db.org/network/9606.ENSP00000253047Transmembrane protein 160.
ZC3H4 protein networkhttps://string-db.org/network/9606.ENSP00000253048Zinc finger CCCH-type containing 4.
MAP3K10 protein networkhttps://string-db.org/network/9606.ENSP00000253055Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase sub [...]
SESN2 protein networkhttps://string-db.org/network/9606.ENSP00000253063Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 a [...]
CCDC62 protein networkhttps://string-db.org/network/9606.ENSP00000253079Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocort [...]
HIP1R protein networkhttps://string-db.org/network/9606.ENSP00000253083Huntingtin-interacting protein 1-related protein; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via [...]
PPAN protein networkhttps://string-db.org/network/9606.ENSP00000253107Suppressor of SWI4 1 homolog; May have a role in cell growth.
EIF3G protein networkhttps://string-db.org/network/9606.ENSP00000253108Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...]
ANGPTL6 protein networkhttps://string-db.org/network/9606.ENSP00000253109Angiopoietin-related protein 6; May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial [...]
SHFL protein networkhttps://string-db.org/network/9606.ENSP00000253110Shiftless antiviral inhibitor of ribosomal frameshifting protein; Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such [...]
ZNF426 protein networkhttps://string-db.org/network/9606.ENSP00000253115Zinc finger protein 426; May be involved in transcriptional regulation.
SLC6A8 protein networkhttps://string-db.org/network/9606.ENSP00000253122Sodium- and chloride-dependent creatine transporter 1; Required for the uptake of creatine in muscles and brain.
ZNF331 protein networkhttps://string-db.org/network/9606.ENSP00000253144Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis.
SLC7A10 protein networkhttps://string-db.org/network/9606.ENSP00000253188Asc-type amino acid transporter 1; Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobil [...]
LRP3 protein networkhttps://string-db.org/network/9606.ENSP00000253193Low-density lipoprotein receptor-related protein 3; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however [...]
GRWD1 protein networkhttps://string-db.org/network/9606.ENSP00000253237Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting [...]
NOL11 protein networkhttps://string-db.org/network/9606.ENSP00000253247Nucleolar protein 11; Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.
PKDREJ protein networkhttps://string-db.org/network/9606.ENSP00000253255Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acro [...]
NUTM2F protein networkhttps://string-db.org/network/9606.ENSP00000253262NUT family member 2F; Belongs to the NUT family.
SLC35D2 protein networkhttps://string-db.org/network/9606.ENSP00000253270UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Ma [...]
PPIL4 protein networkhttps://string-db.org/network/9606.ENSP00000253329Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); [...]
BPIFB1 protein networkhttps://string-db.org/network/9606.ENSP00000253354BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs t [...]
BPIFA2 protein networkhttps://string-db.org/network/9606.ENSP00000253362BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
RBM39 protein networkhttps://string-db.org/network/9606.ENSP00000253363RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.
DEFB118 protein networkhttps://string-db.org/network/9606.ENSP00000253381Beta-defensin 118; Has antibacterial activity.
ACSS2 protein networkhttps://string-db.org/network/9606.ENSP00000253382Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower af [...]
C1QL1 protein networkhttps://string-db.org/network/9606.ENSP00000253407C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
GFAP protein networkhttps://string-db.org/network/9606.ENSP00000253408Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other [...]
HIGD1B protein networkhttps://string-db.org/network/9606.ENSP00000253410HIG1 hypoxia inducible domain family member 1B.
ATP6V1E1 protein networkhttps://string-db.org/network/9606.ENSP00000253413V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intrace [...]
EMC8 protein networkhttps://string-db.org/network/9606.ENSP00000253457ER membrane protein complex subunit 8.
GSE1 protein networkhttps://string-db.org/network/9606.ENSP00000253458Genetic suppressor element 1; Gse1 coiled-coil protein.
GINS2 protein networkhttps://string-db.org/network/9606.ENSP00000253462DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind pref [...]
F12 protein networkhttps://string-db.org/network/9606.ENSP00000253496Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. P [...]
ABCB7 protein networkhttps://string-db.org/network/9606.ENSP00000253577ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iro [...]
HAUS8 protein networkhttps://string-db.org/network/9606.ENSP00000253669HAUS augmin-like complex subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
ADGRE3 protein networkhttps://string-db.org/network/9606.ENSP00000253673Adhesion G protein-coupled receptor E3; Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor [...]
MRPS25 protein networkhttps://string-db.org/network/9606.ENSP00000253686Mitochondrial ribosomal protein S25.
CAPN7 protein networkhttps://string-db.org/network/9606.ENSP00000253693Calpain-7; Calcium-regulated non-lysosomal thiol-protease. Belongs to the peptidase C2 family.
C3orf20 protein networkhttps://string-db.org/network/9606.ENSP00000253697Uncharacterized protein C3orf20; Chromosome 3 open reading frame 20.
RBSN protein networkhttps://string-db.org/network/9606.ENSP00000253699Rabenosyn-5; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathr [...]
NAPSA protein networkhttps://string-db.org/network/9606.ENSP00000253719Napsin-A; May be involved in processing of pneumocyte surfactant precursors.
PDLIM4 protein networkhttps://string-db.org/network/9606.ENSP00000253754PDZ and LIM domain protein 4; [Isoform 1]: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its in [...]
GFPT2 protein networkhttps://string-db.org/network/9606.ENSP00000253778Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N [...]
VPS25 protein networkhttps://string-db.org/network/9606.ENSP00000253794Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation [...]
RAMP2 protein networkhttps://string-db.org/network/9606.ENSP00000253796Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CAL [...]
AOC2 protein networkhttps://string-db.org/network/9606.ENSP00000253799Retina-specific copper amine oxidase; Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulat [...]
G6PC protein networkhttps://string-db.org/network/9606.ENSP00000253801Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose pr [...]
PCDHAC1 protein networkhttps://string-db.org/network/9606.ENSP00000253807Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHGA3 protein networkhttps://string-db.org/network/9606.ENSP00000253812Protocadherin gamma-A3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
NDFIP1 protein networkhttps://string-db.org/network/9606.ENSP00000253814NEDD4 family-interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result [...]
EXOC4 protein networkhttps://string-db.org/network/9606.ENSP00000253861Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
PPFIA1 protein networkhttps://string-db.org/network/9606.ENSP00000253925Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...]
FLYWCH1 protein networkhttps://string-db.org/network/9606.ENSP00000253928FLYWCH-type zinc finger 1.
BARX1 protein networkhttps://string-db.org/network/9606.ENSP00000253968Homeobox protein BarH-like 1; Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars [...]
WDR44 protein networkhttps://string-db.org/network/9606.ENSP00000254029WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
ZCCHC9 protein networkhttps://string-db.org/network/9606.ENSP00000254037Zinc finger CCHC domain-containing protein 9; May down-regulate transcription mediated by NF-kappa-B and the serum response element.
TNS4 protein networkhttps://string-db.org/network/9606.ENSP00000254051Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by casp [...]
RARA protein networkhttps://string-db.org/network/9606.ENSP00000254066Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9- cis retinoic [...]
KRTAP9-8 protein networkhttps://string-db.org/network/9606.ENSP00000254072Keratin-associated protein 9-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
PPP1R1B protein networkhttps://string-db.org/network/9606.ENSP00000254079Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1.
FMO5 protein networkhttps://string-db.org/network/9606.ENSP00000254090Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
PRKAB2 protein networkhttps://string-db.org/network/9606.ENSP000002541015'-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy m [...]
FUS protein networkhttps://string-db.org/network/9606.ENSP00000254108RNA-binding protein FUS; DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Bin [...]
ZNF132 protein networkhttps://string-db.org/network/9606.ENSP00000254166Zinc finger protein 132; May be involved in transcriptional regulation.
USP29 protein networkhttps://string-db.org/network/9606.ENSP00000254181Ubiquitin specific peptidase 29.
CHSY1 protein networkhttps://string-db.org/network/9606.ENSP00000254190Chondroitin sulfate synthase 1; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...]
SNRPA1 protein networkhttps://string-db.org/network/9606.ENSP00000254193U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. Be [...]
NR0B2 protein networkhttps://string-db.org/network/9606.ENSP00000254227Nuclear receptor subfamily 0 group B member 2; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transact [...]
THAP1 protein networkhttps://string-db.org/network/9606.ENSP00000254250THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT [...]
RHPN2 protein networkhttps://string-db.org/network/9606.ENSP00000254260Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA [...]
ACTR10 protein networkhttps://string-db.org/network/9606.ENSP00000254286Actin related protein 10; Belongs to the actin family.
LGALS3 protein networkhttps://string-db.org/network/9606.ENSP00000254301Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for ter [...]
DNAJB1 protein networkhttps://string-db.org/network/9606.ENSP00000254322DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 trans [...]
ZSWIM4 protein networkhttps://string-db.org/network/9606.ENSP00000254323Zinc finger SWIM-type containing 4.
RFX1 protein networkhttps://string-db.org/network/9606.ENSP00000254325MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required fo [...]
C19orf57 protein networkhttps://string-db.org/network/9606.ENSP00000254336Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57.
DCAF15 protein networkhttps://string-db.org/network/9606.ENSP00000254337DDB1- and CUL4-associated factor 15; May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.
TRIM21 protein networkhttps://string-db.org/network/9606.ENSP00000254436E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with [...]
WDR7 protein networkhttps://string-db.org/network/9606.ENSP00000254442WD repeat domain 7.
SMARCC1 protein networkhttps://string-db.org/network/9606.ENSP00000254480SWI/SNF complex subunit SMARCC1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chroma [...]
SLC6A11 protein networkhttps://string-db.org/network/9606.ENSP00000254488Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter [...]
NUP210 protein networkhttps://string-db.org/network/9606.ENSP00000254508Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity.
HSD17B7 protein networkhttps://string-db.org/network/9606.ENSP000002545213-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
EMILIN2 protein networkhttps://string-db.org/network/9606.ENSP00000254528EMILIN-2; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vesse [...]
DNHD1 protein networkhttps://string-db.org/network/9606.ENSP00000254579Dynein heavy chain domain 1.
RRP8 protein networkhttps://string-db.org/network/9606.ENSP00000254605Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy [...]
TIMM10B protein networkhttps://string-db.org/network/9606.ENSP00000254616Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mit [...]
EFR3A protein networkhttps://string-db.org/network/9606.ENSP00000254624Protein EFR3 homolog A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphat [...]
OC90 protein networkhttps://string-db.org/network/9606.ENSP00000254627Otoconin-90; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters [...]
PTCD3 protein networkhttps://string-db.org/network/9606.ENSP00000254630Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation.
ILKAP protein networkhttps://string-db.org/network/9606.ENSP00000254654Integrin-linked kinase-associated serine/threonine phosphatase 2C; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose a [...]
PER2 protein networkhttps://string-db.org/network/9606.ENSP00000254657Period circadian protein homolog 2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiolo [...]
RAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000254661Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP [...]
PTPRE protein networkhttps://string-db.org/network/9606.ENSP00000254667Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in o [...]
CARD6 protein networkhttps://string-db.org/network/9606.ENSP00000254691Caspase recruitment domain-containing protein 6; May be involved in apoptosis.
RAP1GAP2 protein networkhttps://string-db.org/network/9606.ENSP00000254695Rap1 GTPase-activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state.
RPA1 protein networkhttps://string-db.org/network/9606.ENSP00000254719Replication protein A 70 kDa DNA-binding subunit, N-terminally processed; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermed [...]
SERPINF1 protein networkhttps://string-db.org/network/9606.ENSP00000254722Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stress [...]
EEFSEC protein networkhttps://string-db.org/network/9606.ENSP00000254730Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine direc [...]
COQ3 protein networkhttps://string-db.org/network/9606.ENSP00000254759Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
POPDC3 protein networkhttps://string-db.org/network/9606.ENSP00000254765Popeye domain-containing protein 3; May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.
LANCL2 protein networkhttps://string-db.org/network/9606.ENSP00000254770LanC-like protein 2; Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.
GRSF1 protein networkhttps://string-db.org/network/9606.ENSP00000254799G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs c [...]
UTP3 protein networkhttps://string-db.org/network/9606.ENSP00000254803Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 f [...]
H3-3B protein networkhttps://string-db.org/network/9606.ENSP00000254810Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorpo [...]
TRIM47 protein networkhttps://string-db.org/network/9606.ENSP00000254816E3 ubiquitin-protein ligase TRIM47; E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD; Belongs to the TRIM/RBCC family.
KDM6B protein networkhttps://string-db.org/network/9606.ENSP00000254846Lysine-specific demethylase 6B; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethyla [...]
GUCY2D protein networkhttps://string-db.org/network/9606.ENSP00000254854Retinal guanylyl cyclase 1; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May al [...]
CLEC10A protein networkhttps://string-db.org/network/9606.ENSP00000254868C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine unit [...]
RIDA protein networkhttps://string-db.org/network/9606.ENSP000002548782-iminobutanoate/2-iminopropanoate deaminase; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of a [...]
MATN2 protein networkhttps://string-db.org/network/9606.ENSP00000254898Matrilin-2; Involved in matrix assembly.
BRD8 protein networkhttps://string-db.org/network/9606.ENSP00000254900Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHT [...]
ERAL1 protein networkhttps://string-db.org/network/9606.ENSP00000254928GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide [...]
NIP7 protein networkhttps://string-db.org/network/9606.ENSP0000025494060S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.
TERF2 protein networkhttps://string-db.org/network/9606.ENSP00000254942Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes [...]
VPS4A protein networkhttps://string-db.org/network/9606.ENSP00000254950Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes thei [...]
JAG1 protein networkhttps://string-db.org/network/9606.ENSP00000254958Protein jagged-1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early [...]
HSPA12B protein networkhttps://string-db.org/network/9606.ENSP00000254963Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family.
SNAP25 protein networkhttps://string-db.org/network/9606.ENSP00000254976Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Ass [...]
NXT1 protein networkhttps://string-db.org/network/9606.ENSP00000254998NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved [...]
RIN2 protein networkhttps://string-db.org/network/9606.ENSP00000255006Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF [...]
SSTR4 protein networkhttps://string-db.org/network/9606.ENSP00000255008Somatostatin receptor type 4; Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibit [...]
CRP protein networkhttps://string-db.org/network/9606.ENSP00000255030C-reactive protein(1-205); Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calciu [...]
HAPLN2 protein networkhttps://string-db.org/network/9606.ENSP00000255039Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central [...]
APCS protein networkhttps://string-db.org/network/9606.ENSP00000255040Serum amyloid P-component(1-203); Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin; Be [...]
IGHMBP2 protein networkhttps://string-db.org/network/9606.ENSP00000255078DNA-binding protein SMUBP-2; 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of th [...]
ACY3 protein networkhttps://string-db.org/network/9606.ENSP00000255082N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acid [...]
TESMIN protein networkhttps://string-db.org/network/9606.ENSP00000255087Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family.
DPH2 protein networkhttps://string-db.org/network/9606.ENSP000002551082-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation el [...]
NASP protein networkhttps://string-db.org/network/9606.ENSP00000255120Nuclear autoantigenic sperm protein; Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulat [...]
PABPC1L protein networkhttps://string-db.org/network/9606.ENSP00000255136Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like.
ZSWIM3 protein networkhttps://string-db.org/network/9606.ENSP00000255152Zinc finger SWIM-type containing 3.
OSER1 protein networkhttps://string-db.org/network/9606.ENSP00000255174Oxidative stress-responsive serine-rich protein 1; Oxidative stress responsive serine rich 1.
DMGDH protein networkhttps://string-db.org/network/9606.ENSP00000255189Dimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro.
BHMT2 protein networkhttps://string-db.org/network/9606.ENSP00000255192S-methylmethionine--homocysteine S-methyltransferase BHMT2; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl d [...]
AP3B1 protein networkhttps://string-db.org/network/9606.ENSP00000255194AP-3 complex subunit beta-1; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and [...]
ZBED3 protein networkhttps://string-db.org/network/9606.ENSP00000255198Zinc finger BED domain-containing protein 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved i [...]
SYT4 protein networkhttps://string-db.org/network/9606.ENSP00000255224Synaptotagmin-4; Synaptotagmin family member which does not bind Ca(2+) (By similarity). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increas [...]
SLC14A2 protein networkhttps://string-db.org/network/9606.ENSP00000255226Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major rol [...]
NMUR2 protein networkhttps://string-db.org/network/9606.ENSP00000255262Neuromedin-U receptor 2; Receptor for the neuromedin-U and neuromedin-S neuropeptides. Belongs to the G-protein coupled receptor 1 family.
PDE6A protein networkhttps://string-db.org/network/9606.ENSP00000255266Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide pho [...]
USPL1 protein networkhttps://string-db.org/network/9606.ENSP00000255304SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more e [...]
XPO4 protein networkhttps://string-db.org/network/9606.ENSP00000255305Exportin-4; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. [...]
RNF17 protein networkhttps://string-db.org/network/9606.ENSP00000255324RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional rep [...]
CHRM3 protein networkhttps://string-db.org/network/9606.ENSP00000255380Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...]
MYH4 protein networkhttps://string-db.org/network/9606.ENSP00000255381Myosin-4; Muscle contraction.
PEMT protein networkhttps://string-db.org/network/9606.ENSP00000255389Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidyleth [...]
SCO1 protein networkhttps://string-db.org/network/9606.ENSP00000255390Protein SCO1 homolog, mitochondrial; Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays [...]
CHI3L1 protein networkhttps://string-db.org/network/9606.ENSP00000255409Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to an [...]
MYBPH protein networkhttps://string-db.org/network/9606.ENSP00000255416Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band.
CCNA1 protein networkhttps://string-db.org/network/9606.ENSP00000255465Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additi [...]
RFXAP protein networkhttps://string-db.org/network/9606.ENSP00000255476Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters.
RNF128 protein networkhttps://string-db.org/network/9606.ENSP00000255499E3 ubiquitin-protein ligase RNF128; E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcripti [...]
BTBD2 protein networkhttps://string-db.org/network/9606.ENSP00000255608BTB/POZ domain-containing protein 2; BTB domain containing 2.
KMT5C protein networkhttps://string-db.org/network/9606.ENSP00000255613Histone-lysine N-methyltransferase KMT5C; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce r [...]
HSPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000255631Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination media [...]
CSNK1G2 protein networkhttps://string-db.org/network/9606.ENSP00000255641Casein kinase I isoform gamma-2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...]
MACROD1 protein networkhttps://string-db.org/network/9606.ENSP00000255681ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Dea [...]
PLAAT4 protein networkhttps://string-db.org/network/9606.ENSP00000255688Phospholipase A and acyltransferase 4; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of [...]
PLAAT2 protein networkhttps://string-db.org/network/9606.ENSP00000255695Phospholipase A and acyltransferase 2; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent re [...]
MED10 protein networkhttps://string-db.org/network/9606.ENSP00000255764Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
CCDC134 protein networkhttps://string-db.org/network/9606.ENSP00000255784Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tu [...]
SEC14L4 protein networkhttps://string-db.org/network/9606.ENSP00000255858SEC14-like protein 4; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
PI4KA protein networkhttps://string-db.org/network/9606.ENSP00000255882Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3 [...]
MKRN1 protein networkhttps://string-db.org/network/9606.ENSP00000255977E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and [...]
ACTR3B protein networkhttps://string-db.org/network/9606.ENSP00000256001Actin-related protein 3B; Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymeri [...]
NTS protein networkhttps://string-db.org/network/9606.ENSP00000256010Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family.
BTG1 protein networkhttps://string-db.org/network/9606.ENSP00000256015Protein BTG1; Anti-proliferative protein.
KRAS protein networkhttps://string-db.org/network/9606.ENSP00000256078GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting on [...]
IPO8 protein networkhttps://string-db.org/network/9606.ENSP00000256079Importin-8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB [...]
PMP2 protein networkhttps://string-db.org/network/9606.ENSP00000256103Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
FABP4 protein networkhttps://string-db.org/network/9606.ENSP00000256104Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cogna [...]
CCDC59 protein networkhttps://string-db.org/network/9606.ENSP00000256151Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein N [...]
LYVE1 protein networkhttps://string-db.org/network/9606.ENSP00000256178Lymphatic vessel endothelial hyaluronic acid receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulati [...]
SBF2 protein networkhttps://string-db.org/network/9606.ENSP00000256190Myotubularin-related protein 13; Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins [...]
MICAL2 protein networkhttps://string-db.org/network/9606.ENSP00000256194[F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resu [...]
RRAS2 protein networkhttps://string-db.org/network/9606.ENSP00000256196Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect th [...]
SARAF protein networkhttps://string-db.org/network/9606.ENSP00000256255Store-operated calcium entry-associated regulatory factor; Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic [...]
RNF122 protein networkhttps://string-db.org/network/9606.ENSP00000256257RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability.
DUSP26 protein networkhttps://string-db.org/network/9606.ENSP00000256261Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kina [...]
ERG28 protein networkhttps://string-db.org/network/9606.ENSP00000256319Ergosterol biosynthesis 28 homolog; Belongs to the ERG28 family.
UNC79 protein networkhttps://string-db.org/network/9606.ENSP00000256339Protein unc-79 homolog; Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability; Belongs t [...]
CATSPERB protein networkhttps://string-db.org/network/9606.ENSP00000256343Cation channel sperm-associated protein subunit beta; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility wh [...]
VRTN protein networkhttps://string-db.org/network/9606.ENSP00000256362Vertnin; Vertebrae development associated; Belongs to the vertnin family.
SYNJ2BP protein networkhttps://string-db.org/network/9606.ENSP00000256366Synaptojanin-2-binding protein; Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal tran [...]
TTC9 protein networkhttps://string-db.org/network/9606.ENSP00000256367Tetratricopeptide repeat domain 9; Belongs to the TTC9 family.
EIF2S1 protein networkhttps://string-db.org/network/9606.ENSP00000256383Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribos [...]
ELP3 protein networkhttps://string-db.org/network/9606.ENSP00000256398Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved [...]
PEBP4 protein networkhttps://string-db.org/network/9606.ENSP00000256404Phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine e [...]
ADAMDEC1 protein networkhttps://string-db.org/network/9606.ENSP00000256412ADAM DEC1; May play an important role in the control of the immune response and during pregnancy.
MBD2 protein networkhttps://string-db.org/network/9606.ENSP00000256429Methyl-CpG-binding domain protein 2; Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits hist [...]
IER3IP1 protein networkhttps://string-db.org/network/9606.ENSP00000256433Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By simi [...]
MRPS36 protein networkhttps://string-db.org/network/9606.ENSP00000256441Mitochondrial ribosomal protein S36.
CCNB1 protein networkhttps://string-db.org/network/9606.ENSP00000256442G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily.
CDK7 protein networkhttps://string-db.org/network/9606.ENSP00000256443Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding [...]
CD180 protein networkhttps://string-db.org/network/9606.ENSP00000256447CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/ [...]
IRAK2 protein networkhttps://string-db.org/network/9606.ENSP00000256458Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation [...]
CAMK1 protein networkhttps://string-db.org/network/9606.ENSP00000256460Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regu [...]
VHL protein networkhttps://string-db.org/network/9606.ENSP00000256474Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recrui [...]
BHLHE40 protein networkhttps://string-db.org/network/9606.ENSP00000256495Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controll [...]
EDEM1 protein networkhttps://string-db.org/network/9606.ENSP00000256497ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved [...]
CHL1 protein networkhttps://string-db.org/network/9606.ENSP00000256509Processed neural cell adhesion molecule L1-like protein; Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble an [...]
DPH6 protein networkhttps://string-db.org/network/9606.ENSP00000256538Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue i [...]
KATNBL1 protein networkhttps://string-db.org/network/9606.ENSP00000256544KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro.
EMC7 protein networkhttps://string-db.org/network/9606.ENSP00000256545ER membrane protein complex subunit 7; Belongs to the EMC7 family.
TSHB protein networkhttps://string-db.org/network/9606.ENSP00000256592Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Belongs to the glycoprotein hormones subunit beta family.
GSTM5 protein networkhttps://string-db.org/network/9606.ENSP00000256593Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
SORT1 protein networkhttps://string-db.org/network/9606.ENSP00000256637Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a p [...]
LAMTOR5 protein networkhttps://string-db.org/network/9606.ENSP00000256644Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...]
NOTCH2 protein networkhttps://string-db.org/network/9606.ENSP00000256646Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand a [...]
TRIM45 protein networkhttps://string-db.org/network/9606.ENSP00000256649Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
ARF3 protein networkhttps://string-db.org/network/9606.ENSP00000256682ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may mo [...]
SLC38A2 protein networkhttps://string-db.org/network/9606.ENSP00000256689Sodium-coupled neutral amino acid transporter 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids a [...]
KIDINS220 protein networkhttps://string-db.org/network/9606.ENSP00000256707Kinase D-interacting substrate of 220 kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G co [...]
CMPK2 protein networkhttps://string-db.org/network/9606.ENSP00000256722UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs [...]
ANO3 protein networkhttps://string-db.org/network/9606.ENSP00000256737Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhi [...]
FST protein networkhttps://string-db.org/network/9606.ENSP00000256759Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
CFHR5 protein networkhttps://string-db.org/network/9606.ENSP00000256785Complement factor H-related protein 5; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...]
ERN2 protein networkhttps://string-db.org/network/9606.ENSP00000256797Serine/threonine-protein kinase/endoribonuclease IRE2; Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the [...]
NARS1 protein networkhttps://string-db.org/network/9606.ENSP00000256854Asparagine--tRNA ligase, cytoplasmic; Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the [...]
GRP protein networkhttps://string-db.org/network/9606.ENSP00000256857Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch [...]
RELCH protein networkhttps://string-db.org/network/9606.ENSP00000256858RAB11-binding protein RELCH; Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane t [...]
HRH4 protein networkhttps://string-db.org/network/9606.ENSP00000256906Histamine H4 receptor; The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activit [...]
CABLES1 protein networkhttps://string-db.org/network/9606.ENSP00000256925CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by acti [...]
EMP1 protein networkhttps://string-db.org/network/9606.ENSP00000256951Epithelial membrane protein 1.
RERG protein networkhttps://string-db.org/network/9606.ENSP00000256953Ras-related and estrogen-regulated growth inhibitor; Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduc [...]
SLCO1B1 protein networkhttps://string-db.org/network/9606.ENSP00000256958Solute carrier organic anion transporter family member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate [...]
SPX protein networkhttps://string-db.org/network/9606.ENSP00000256969Spexin-1; Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation [...]
DDB2 protein networkhttps://string-db.org/network/9606.ENSP00000256996DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damag [...]
FOLH1 protein networkhttps://string-db.org/network/9606.ENSP00000256999Glutamate carboxypeptidase 2; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestin [...]
RTL8C protein networkhttps://string-db.org/network/9606.ENSP00000257013Retrotransposon Gag like 8C; Belongs to the FAM127 family.
RAB33A protein networkhttps://string-db.org/network/9606.ENSP00000257017Ras-related protein Rab-33A; RAB33A, member RAS oncogene family.
MTNR1B protein networkhttps://string-db.org/network/9606.ENSP00000257068Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis tox [...]
PHC2 protein networkhttps://string-db.org/network/9606.ENSP00000257118Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
TUT4 protein networkhttps://string-db.org/network/9606.ENSP00000257177Terminal uridylyltransferase 4; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Esse [...]
PRPF38A protein networkhttps://string-db.org/network/9606.ENSP00000257181Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome.
DSG3 protein networkhttps://string-db.org/network/9606.ENSP00000257189Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
DSG1 protein networkhttps://string-db.org/network/9606.ENSP00000257192Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
DSC1 protein networkhttps://string-db.org/network/9606.ENSP00000257198Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...]
DAGLA protein networkhttps://string-db.org/network/9606.ENSP00000257215Sn1-specific diacylglycerol lipase alpha; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal gr [...]
TIMM10 protein networkhttps://string-db.org/network/9606.ENSP00000257245Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mi [...]
CBLIF protein networkhttps://string-db.org/network/9606.ENSP00000257248Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via recepto [...]
TCN1 protein networkhttps://string-db.org/network/9606.ENSP00000257264Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach; Belongs to the eukaryotic cobalamin transport proteins family.
CEP135 protein networkhttps://string-db.org/network/9606.ENSP00000257287Centrosomal protein of 135 kDa; Involved in early centriole assembly/duplication/biogenesis/formation/. Required for centriole elongation. Required for the recruitment of CEP295 to the proximal e [...]
PDGFRA protein networkhttps://string-db.org/network/9606.ENSP00000257290Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic d [...]
DZIP1 protein networkhttps://string-db.org/network/9606.ENSP00000257312Zinc finger protein DZIP1; May participate in spermatogenesis via its interaction with DAZ. Has a role in primary cilium formation ; Belongs to the DZIP C2H2-type zinc-finger protein family.
BIVM protein networkhttps://string-db.org/network/9606.ENSP00000257336Basic, immunoglobulin-like variable motif containing.
CARS2 protein networkhttps://string-db.org/network/9606.ENSP00000257347Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.
ADAMTS8 protein networkhttps://string-db.org/network/9606.ENSP00000257359A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties.
KLB protein networkhttps://string-db.org/network/9606.ENSP00000257408Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increa [...]
SEMA6A protein networkhttps://string-db.org/network/9606.ENSP00000257414Semaphorin-6A; Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganizati [...]
APC protein networkhttps://string-db.org/network/9606.ENSP00000257430Adenomatous polyposis coli protein; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphory [...]
ADAM19 protein networkhttps://string-db.org/network/9606.ENSP00000257527Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, [...]
USP30 protein networkhttps://string-db.org/network/9606.ENSP00000257548Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRK [...]
SDS protein networkhttps://string-db.org/network/9606.ENSP00000257549L-serine dehydratase/L-threonine deaminase; Serine dehydratase.
MSI1 protein networkhttps://string-db.org/network/9606.ENSP00000257552RNA-binding protein Musashi homolog 1; RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA co [...]
TBX3 protein networkhttps://string-db.org/network/9606.ENSP00000257566T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in ce [...]
OASL protein networkhttps://string-db.org/network/9606.ENSP000002575702'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatiti [...]
HRK protein networkhttps://string-db.org/network/9606.ENSP00000257572Activator of apoptosis harakiri; Promotes apoptosis.
RNFT2 protein networkhttps://string-db.org/network/9606.ENSP00000257575Ring finger protein, transmembrane 2.
DTX1 protein networkhttps://string-db.org/network/9606.ENSP00000257600E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway v [...]
TRAFD1 protein networkhttps://string-db.org/network/9606.ENSP00000257604TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like heli [...]
GSAP protein networkhttps://string-db.org/network/9606.ENSP00000257626Gamma-secretase-activating protein 16 kDa C-terminal form; Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and [...]
OCM2 protein networkhttps://string-db.org/network/9606.ENSP00000257627Putative oncomodulin-2; Oncomodulin 2; Belongs to the parvalbumin family.
TMEM60 protein networkhttps://string-db.org/network/9606.ENSP00000257663Transmembrane protein 60.
PNPLA8 protein networkhttps://string-db.org/network/9606.ENSP00000257694Calcium-independent phospholipase A2-gamma; Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. [...]
HILPDA protein networkhttps://string-db.org/network/9606.ENSP00000257696Hypoxia-inducible lipid droplet-associated protein; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and prolifera [...]
RINT1 protein networkhttps://string-db.org/network/9606.ENSP00000257700RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ comp [...]
MDFIC protein networkhttps://string-db.org/network/9606.ENSP00000257724MyoD family inhibitor domain-containing protein; Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nucl [...]
BACH2 protein networkhttps://string-db.org/network/9606.ENSP00000257749Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important [...]
NT5E protein networkhttps://string-db.org/network/9606.ENSP000002577705'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.
MRAP2 protein networkhttps://string-db.org/network/9606.ENSP00000257776Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and [...]
AKIRIN2 protein networkhttps://string-db.org/network/9606.ENSP00000257787Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex wit [...]
ORC3 protein networkhttps://string-db.org/network/9606.ENSP00000257789Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...]
LMO2 protein networkhttps://string-db.org/network/9606.ENSP00000257818Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
NAT10 protein networkhttps://string-db.org/network/9606.ENSP00000257829RNA cytidine acetyltransferase; RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of [...]
PRRG4 protein networkhttps://string-db.org/network/9606.ENSP00000257836Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS. Prevents the delivery of ROBO1 at the cell surface and downregulates its expression ; Belongs to the [...]
PRPH protein networkhttps://string-db.org/network/9606.ENSP00000257860Peripherin; Class-III neuronal intermediate filament protein; Belongs to the intermediate filament family.
AVIL protein networkhttps://string-db.org/network/9606.ENSP00000257861Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outg [...]
AMHR2 protein networkhttps://string-db.org/network/9606.ENSP00000257863Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphoryla [...]
LACRT protein networkhttps://string-db.org/network/9606.ENSP00000257867Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells.
GDF11 protein networkhttps://string-db.org/network/9606.ENSP00000257868Growth/differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning bot [...]
FAM186B protein networkhttps://string-db.org/network/9606.ENSP00000257894Protein FAM186B; Family with sequence similarity 186 member B.
RDH5 protein networkhttps://string-db.org/network/9606.ENSP00000257895Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By [...]
KRT85 protein networkhttps://string-db.org/network/9606.ENSP00000257901Keratin, type II cuticular Hb5; Keratin 85; Belongs to the intermediate filament family.
CDK4 protein networkhttps://string-db.org/network/9606.ENSP00000257904Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the [...]
PPP1R1A protein networkhttps://string-db.org/network/9606.ENSP00000257905Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP [...]
TROAP protein networkhttps://string-db.org/network/9606.ENSP00000257909Tastin; Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo [...]
TSPAN31 protein networkhttps://string-db.org/network/9606.ENSP00000257910Tetraspanin-31; Tetraspanin 31.
TFCP2 protein networkhttps://string-db.org/network/9606.ENSP00000257915Alpha-globin transcription factor CP2; Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in ery [...]
ESPL1 protein networkhttps://string-db.org/network/9606.ENSP00000257934Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cel [...]
ZC3H10 protein networkhttps://string-db.org/network/9606.ENSP00000257940Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1- type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and [...]
KRT84 protein networkhttps://string-db.org/network/9606.ENSP00000257951Keratin, type II cuticular Hb4; Keratin 84.
KRT82 protein networkhttps://string-db.org/network/9606.ENSP00000257974Keratin, type II cuticular Hb2; Keratin 82; Belongs to the intermediate filament family.
KCNH3 protein networkhttps://string-db.org/network/9606.ENSP00000257981Potassium voltage-gated channel subfamily H member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be [...]
TAAR5 protein networkhttps://string-db.org/network/9606.ENSP00000258034Trace amine-associated receptor 5; Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite fou [...]
NMBR protein networkhttps://string-db.org/network/9606.ENSP00000258042Neuromedin-B receptor; Receptor for neuromedin-B.
SMPD2 protein networkhttps://string-db.org/network/9606.ENSP00000258052Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso- sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-plate [...]
HTRA2 protein networkhttps://string-db.org/network/9606.ENSP00000258080Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and [...]
PRADC1 protein networkhttps://string-db.org/network/9606.ENSP00000258083Protease-associated domain-containing protein 1; Protease associated domain containing 1.
CCT7 protein networkhttps://string-db.org/network/9606.ENSP00000258091T-complex protein 1 subunit eta, N-terminally processed; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydro [...]
RAB11FIP5 protein networkhttps://string-db.org/network/9606.ENSP00000258098Rab11 family-interacting protein 5; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulat [...]
MRPL53 protein networkhttps://string-db.org/network/9606.ENSP00000258105Mitochondrial ribosomal protein L53.
EMX1 protein networkhttps://string-db.org/network/9606.ENSP00000258106Homeobox protein EMX1; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations [...]
KCNMB4 protein networkhttps://string-db.org/network/9606.ENSP00000258111Calcium-activated potassium channel subunit beta-4; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...]
GNS protein networkhttps://string-db.org/network/9606.ENSP00000258145N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family.
MDM2 protein networkhttps://string-db.org/network/9606.ENSP00000258149E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell [...]
BCO1 protein networkhttps://string-db.org/network/9606.ENSP00000258168Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family.
MPHOSPH6 protein networkhttps://string-db.org/network/9606.ENSP00000258169M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting t [...]
TMEM231 protein networkhttps://string-db.org/network/9606.ENSP00000258173Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of tra [...]
DYNC1LI2 protein networkhttps://string-db.org/network/9606.ENSP00000258198Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to [...]
FBXL8 protein networkhttps://string-db.org/network/9606.ENSP00000258200F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
FHOD1 protein networkhttps://string-db.org/network/9606.ENSP00000258201FH1/FH2 domain-containing protein 1; Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of m [...]
CCDC102A protein networkhttps://string-db.org/network/9606.ENSP00000258214Coiled-coil domain containing 102A.
PCNX2 protein networkhttps://string-db.org/network/9606.ENSP00000258229Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H). Belongs to the pecanex family.
URB2 protein networkhttps://string-db.org/network/9606.ENSP00000258243URB2 ribosome biogenesis homolog.
TAF5L protein networkhttps://string-db.org/network/9606.ENSP00000258281TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating hi [...]
STX6 protein networkhttps://string-db.org/network/9606.ENSP00000258301Syntaxin-6; Involved in intracellular vesicle trafficking.
RGS8 protein networkhttps://string-db.org/network/9606.ENSP00000258302Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similar [...]
NPL protein networkhttps://string-db.org/network/9606.ENSP00000258317N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from b [...]
LAMC1 protein networkhttps://string-db.org/network/9606.ENSP00000258341Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
SP110 protein networkhttps://string-db.org/network/9606.ENSP00000258381Sp110 nuclear body protein; Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
MRPL44 protein networkhttps://string-db.org/network/9606.ENSP0000025838339S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the r [...]
CHRND protein networkhttps://string-db.org/network/9606.ENSP00000258385Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...]
USP37 protein networkhttps://string-db.org/network/9606.ENSP00000258399Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2) [...]
HTR2B protein networkhttps://string-db.org/network/9606.ENSP000002584005-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. L [...]
WNT10A protein networkhttps://string-db.org/network/9606.ENSP00000258411Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role [...]
CYP27A1 protein networkhttps://string-db.org/network/9606.ENSP00000258415Sterol 26-hydroxylase, mitochondrial; Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry [...]
EIF4E2 protein networkhttps://string-db.org/network/9606.ENSP00000258416Eukaryotic translation initiation factor 4E type 2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initi [...]
CAB39 protein networkhttps://string-db.org/network/9606.ENSP00000258418Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25bet [...]
COX5B protein networkhttps://string-db.org/network/9606.ENSP00000258424Cytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
REV1 protein networkhttps://string-db.org/network/9606.ENSP00000258428DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the fir [...]
MFSD9 protein networkhttps://string-db.org/network/9606.ENSP00000258436Major facilitator superfamily domain containing 9.
TMEM127 protein networkhttps://string-db.org/network/9606.ENSP00000258439Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
EDAR protein networkhttps://string-db.org/network/9606.ENSP00000258443Tumor necrosis factor receptor superfamily member EDAR; Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase- independent ce [...]
MRPS9 protein networkhttps://string-db.org/network/9606.ENSP00000258455Mitochondrial ribosomal protein S9.
GPR45 protein networkhttps://string-db.org/network/9606.ENSP00000258456Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function.
C2orf49 protein networkhttps://string-db.org/network/9606.ENSP00000258457Ashwin; Chromosome 2 open reading frame 49; Belongs to the ashwin family.
EPC2 protein networkhttps://string-db.org/network/9606.ENSP00000258484Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair. Belongs to the enhancer of polycomb family.
ALDH1L2 protein networkhttps://string-db.org/network/9606.ENSP00000258494Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family.
USP44 protein networkhttps://string-db.org/network/9606.ENSP00000258499Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by [...]
PLXNC1 protein networkhttps://string-db.org/network/9606.ENSP00000258526Plexin-C1; Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the re [...]
DRAM1 protein networkhttps://string-db.org/network/9606.ENSP00000258534DNA damage-regulated autophagy modulator protein 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
SLC41A2 protein networkhttps://string-db.org/network/9606.ENSP00000258538Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter.
THSD1 protein networkhttps://string-db.org/network/9606.ENSP00000258613Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1.
MED4 protein networkhttps://string-db.org/network/9606.ENSP00000258648Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
COG3 protein networkhttps://string-db.org/network/9606.ENSP00000258654Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport.
NUDT15 protein networkhttps://string-db.org/network/9606.ENSP00000258662Nucleotide triphosphate diphosphatase NUDT15; May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine d [...]
SPDYE1 protein networkhttps://string-db.org/network/9606.ENSP00000258704Speedy protein E1; speedy/RINGO cell cycle regulator family member E1.
IGF2BP3 protein networkhttps://string-db.org/network/9606.ENSP00000258729Insulin-like growth factor 2 mRNA-binding protein 3; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allow [...]
KDELR2 protein networkhttps://string-db.org/network/9606.ENSP00000258739ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Gol [...]
NUP42 protein networkhttps://string-db.org/network/9606.ENSP00000258742Nucleoporin NUP42; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm.
TBRG4 protein networkhttps://string-db.org/network/9606.ENSP00000258770FAST kinase domain-containing protein 4; Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, M [...]
DDX56 protein networkhttps://string-db.org/network/9606.ENSP00000258772Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre- ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activit [...]
HUS1 protein networkhttps://string-db.org/network/9606.ENSP00000258774Checkpoint protein HUS1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17 [...]
MYO1G protein networkhttps://string-db.org/network/9606.ENSP00000258787Minor histocompatibility antigen HA-2; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins [...]
TTYH3 protein networkhttps://string-db.org/network/9606.ENSP00000258796Protein tweety homolog 3; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. Belongs to the tweety family.
TTC5 protein networkhttps://string-db.org/network/9606.ENSP00000258821Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interac [...]
NKX2-8 protein networkhttps://string-db.org/network/9606.ENSP00000258829Homeobox protein Nkx-2.8; NK2 homeobox 8.
ACSBG1 protein networkhttps://string-db.org/network/9606.ENSP00000258873Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular [...]
MTHFS protein networkhttps://string-db.org/network/9606.ENSP000002588745-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for th [...]
ABHD17C protein networkhttps://string-db.org/network/9606.ENSP00000258884Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. Belongs to the [...]
IREB2 protein networkhttps://string-db.org/network/9606.ENSP00000258886Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevuli [...]
ALPK3 protein networkhttps://string-db.org/network/9606.ENSP00000258888Alpha-protein kinase 3; Involved in cardiomyocyte differentiation.
CIB2 protein networkhttps://string-db.org/network/9606.ENSP00000258930Calcium and integrin-binding family member 2; Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreas [...]
RSAD1 protein networkhttps://string-db.org/network/9606.ENSP00000258955Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyri [...]
SRSF1 protein networkhttps://string-db.org/network/9606.ENSP00000258962Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal componen [...]
CHAD protein networkhttps://string-db.org/network/9606.ENSP00000258969Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play a [...]
TACO1 protein networkhttps://string-db.org/network/9606.ENSP00000258975Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1; Belongs to the TACO1 family.
TEX2 protein networkhttps://string-db.org/network/9606.ENSP00000258991Testis-expressed protein 2; Testis expressed 2.
LIMD2 protein networkhttps://string-db.org/network/9606.ENSP00000259006LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility.
BRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000259008Fanconi anemia group J protein; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquit [...]
KAT7 protein networkhttps://string-db.org/network/9606.ENSP00000259021Histone acetyltransferase KAT7; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of h [...]
RTP4 protein networkhttps://string-db.org/network/9606.ENSP00000259030Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional e [...]
NDUFB5 protein networkhttps://string-db.org/network/9606.ENSP00000259037NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...]
CD302 protein networkhttps://string-db.org/network/9606.ENSP00000259053CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.
GALNT5 protein networkhttps://string-db.org/network/9606.ENSP00000259056Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threon [...]
TANK protein networkhttps://string-db.org/network/9606.ENSP00000259075TRAF family member-associated NF-kappa-B activator; Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immu [...]
BLK protein networkhttps://string-db.org/network/9606.ENSP00000259089Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight reg [...]
KCTD3 protein networkhttps://string-db.org/network/9606.ENSP00000259154BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and c [...]
CBWD2 protein networkhttps://string-db.org/network/9606.ENSP00000259199COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
IL36G protein networkhttps://string-db.org/network/9606.ENSP00000259205Interleukin-36 gamma; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signa [...]
IL1RN protein networkhttps://string-db.org/network/9606.ENSP00000259206Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no inte [...]
IL36A protein networkhttps://string-db.org/network/9606.ENSP00000259211Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflamma [...]
IL36RN protein networkhttps://string-db.org/network/9606.ENSP00000259212Interleukin-36 receptor antagonist protein; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP [...]
IL36B protein networkhttps://string-db.org/network/9606.ENSP00000259213Interleukin-36 beta; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammat [...]
CFC1 protein networkhttps://string-db.org/network/9606.ENSP00000259216Cryptic protein; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation; Belongs to the EGF-CFC (C [...]
CCDC115 protein networkhttps://string-db.org/network/9606.ENSP00000259229Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, requ [...]
IMP4 protein networkhttps://string-db.org/network/9606.ENSP00000259239U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processi [...]
HS6ST1 protein networkhttps://string-db.org/network/9606.ENSP00000259241Heparan-sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...]
UGGT1 protein networkhttps://string-db.org/network/9606.ENSP00000259253UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality [...]
GYPC protein networkhttps://string-db.org/network/9606.ENSP00000259254Glycophorin-C; This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely locate [...]
LRRC8A protein networkhttps://string-db.org/network/9606.ENSP00000259324Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell vo [...]
ECPAS protein networkhttps://string-db.org/network/9606.ENSP00000259335Proteasome adapter and scaffold protein ECM29; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to d [...]
TOR1B protein networkhttps://string-db.org/network/9606.ENSP00000259339Torsin-1B; May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non- neural cells nuclear envelope and endoplasmic reticulum in [...]
RALGPS1 protein networkhttps://string-db.org/network/9606.ENSP00000259351Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine [...]
OR1J1 protein networkhttps://string-db.org/network/9606.ENSP00000259357Olfactory receptor 1J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR13C9 protein networkhttps://string-db.org/network/9606.ENSP00000259362Olfactory receptor 13C9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMOD1 protein networkhttps://string-db.org/network/9606.ENSP00000259365Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...]
DAB2IP protein networkhttps://string-db.org/network/9606.ENSP00000259371Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several pr [...]
SLC31A2 protein networkhttps://string-db.org/network/9606.ENSP00000259392Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake.
ORM1 protein networkhttps://string-db.org/network/9606.ENSP00000259396Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their d [...]
STX17 protein networkhttps://string-db.org/network/9606.ENSP00000259400Syntaxin-17; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemb [...]
BAAT protein networkhttps://string-db.org/network/9606.ENSP00000259407Bile acid-CoA:amino acid N-acyltransferase; Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine. More than 95% of the BAs are N-acyl amidates with glycine and tau [...]
GABBR2 protein networkhttps://string-db.org/network/9606.ENSP00000259455Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABB [...]
HEMGN protein networkhttps://string-db.org/network/9606.ENSP00000259456Hemogen; Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell [...]
PSMB7 protein networkhttps://string-db.org/network/9606.ENSP00000259457Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
OR1L4 protein networkhttps://string-db.org/network/9606.ENSP00000259466Olfactory receptor 1L4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PDCL protein networkhttps://string-db.org/network/9606.ENSP00000259467Phosducin-like protein; Acts as a positive regulator of hedgehog signaling and regulates ciliary function. [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapp [...]
RPL35 protein networkhttps://string-db.org/network/9606.ENSP0000025946960S ribosomal protein L35; Component of the large ribosomal subunit.
CTSV protein networkhttps://string-db.org/network/9606.ENSP00000259470Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family.
ENPP2 protein networkhttps://string-db.org/network/9606.ENSP00000259486Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substra [...]
DERL1 protein networkhttps://string-db.org/network/9606.ENSP00000259512Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded [...]
CCN3 protein networkhttps://string-db.org/network/9606.ENSP00000259526CCN family member 3; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins [...]
RANBP6 protein networkhttps://string-db.org/network/9606.ENSP00000259569Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor.
RNF38 protein networkhttps://string-db.org/network/9606.ENSP00000259605E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhi [...]
CCL21 protein networkhttps://string-db.org/network/9606.ENSP00000259607C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferen [...]
SIT1 protein networkhttps://string-db.org/network/9606.ENSP00000259608Signaling threshold-regulating transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells.
CCL27 protein networkhttps://string-db.org/network/9606.ENSP00000259631C-C motif chemokine 27; Chemotactic factor that attracts skin-associated memory T- lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.
DCTN3 protein networkhttps://string-db.org/network/9606.ENSP00000259632Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis.
CD72 protein networkhttps://string-db.org/network/9606.ENSP00000259633B-cell differentiation antigen CD72; Plays a role in B-cell proliferation and differentiation.
HINT2 protein networkhttps://string-db.org/network/9606.ENSP00000259667Histidine triad nucleotide-binding protein 2, mitochondrial; Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity. Belongs to [...]
RIPOR2 protein networkhttps://string-db.org/network/9606.ENSP00000259698Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte [...]
KLC4 protein networkhttps://string-db.org/network/9606.ENSP00000259708Kinesin light chain 4; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...]
KIF13A protein networkhttps://string-db.org/network/9606.ENSP00000259711Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) [...]
GMPR protein networkhttps://string-db.org/network/9606.ENSP00000259727GMP reductase 1; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, a [...]
TMEM63B protein networkhttps://string-db.org/network/9606.ENSP00000259746CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity).
TTBK1 protein networkhttps://string-db.org/network/9606.ENSP00000259750Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
TINAG protein networkhttps://string-db.org/network/9606.ENSP00000259782Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
GCM1 protein networkhttps://string-db.org/network/9606.ENSP00000259803Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast [...]
RIPK1 protein networkhttps://string-db.org/network/9606.ENSP00000259808Receptor-interacting serine/threonine-protein kinase 1; Serine-threonine kinase which is a key regulator of both cell death and cell survival. Exhibits kinase activity- dependent functions that t [...]
TUBB2B protein networkhttps://string-db.org/network/9606.ENSP00000259818Tubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non- exchangeable site on the alpha [...]
PSORS1C2 protein networkhttps://string-db.org/network/9606.ENSP00000259845Psoriasis susceptibility 1 candidate 2.
C6orf15 protein networkhttps://string-db.org/network/9606.ENSP00000259870Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15.
MRPS18B protein networkhttps://string-db.org/network/9606.ENSP00000259873Mitochondrial ribosomal protein S18B; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
IER3 protein networkhttps://string-db.org/network/9606.ENSP00000259874Radiation-inducible immediate-early gene IEX-1; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK [...]
PSORS1C1 protein networkhttps://string-db.org/network/9606.ENSP00000259881Psoriasis susceptibility 1 candidate 1.
PGBD1 protein networkhttps://string-db.org/network/9606.ENSP00000259883piggyBac transposable element derived 1.
GTF2H4 protein networkhttps://string-db.org/network/9606.ENSP00000259895General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotid [...]
POU5F1 protein networkhttps://string-db.org/network/9606.ENSP00000259915POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression [...]
CLPS protein networkhttps://string-db.org/network/9606.ENSP00000259938Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an i [...]
RNF144B protein networkhttps://string-db.org/network/9606.ENSP00000259939E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly trans [...]
HLA-F protein networkhttps://string-db.org/network/9606.ENSP00000259951HLA class I histocompatibility antigen, alpha chain F; Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation [...]
NRM protein networkhttps://string-db.org/network/9606.ENSP00000259953Nurim.
FAM8A1 protein networkhttps://string-db.org/network/9606.ENSP00000259963Protein FAM8A1; Family with sequence similarity 8 member A1.
C6orf52 protein networkhttps://string-db.org/network/9606.ENSP00000259983Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52.
FGFBP2 protein networkhttps://string-db.org/network/9606.ENSP00000259989Fibroblast growth factor binding protein 2.
TLR2 protein networkhttps://string-db.org/network/9606.ENSP00000260010Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the in [...]
THAP12 protein networkhttps://string-db.org/network/9606.ENSP0000026004552 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulti [...]
MRPL15 protein networkhttps://string-db.org/network/9606.ENSP00000260102Mitochondrial ribosomal protein L15.
PI15 protein networkhttps://string-db.org/network/9606.ENSP00000260113Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity). Belon [...]
TTPA protein networkhttps://string-db.org/network/9606.ENSP00000260116Alpha-tocopherol transfer protein; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosph [...]
GGH protein networkhttps://string-db.org/network/9606.ENSP00000260118Gamma-glutamyl hydrolase; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-g [...]
SLCO5A1 protein networkhttps://string-db.org/network/9606.ENSP00000260126Solute carrier organic anion transporter family member 5A1; Belongs to the organo anion transporter (TC 2.A.60) family.
SULF1 protein networkhttps://string-db.org/network/9606.ENSP00000260128Extracellular sulfatase Sulf-1; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specif [...]
TGS1 protein networkhttps://string-db.org/network/9606.ENSP00000260129Trimethylguanosine synthase; Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) [...]
DDX60L protein networkhttps://string-db.org/network/9606.ENSP00000260184Probable ATP-dependent RNA helicase DDX60-like; DExD/H-box 60 like; Belongs to the helicase family.
USP2 protein networkhttps://string-db.org/network/9606.ENSP00000260187Ubiquitin carboxyl-terminal hydrolase 2; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific pep [...]
HTR3B protein networkhttps://string-db.org/network/9606.ENSP000002601915-hydroxytryptamine receptor 3B; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
SORL1 protein networkhttps://string-db.org/network/9606.ENSP00000260197Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sortin [...]
BUD13 protein networkhttps://string-db.org/network/9606.ENSP00000260210BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome.
MMP7 protein networkhttps://string-db.org/network/9606.ENSP00000260227Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
MMP20 protein networkhttps://string-db.org/network/9606.ENSP00000260228Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and th [...]
MMP27 protein networkhttps://string-db.org/network/9606.ENSP00000260229Matrix metalloproteinase-27; Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.
DCUN1D5 protein networkhttps://string-db.org/network/9606.ENSP00000260247DCN1-like protein 5; Defective in cullin neddylation 1 domain containing 5.
FDXACB1 protein networkhttps://string-db.org/network/9606.ENSP00000260257Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1.
POU2F3 protein networkhttps://string-db.org/network/9606.ENSP00000260264POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lact [...]
FDX1 protein networkhttps://string-db.org/network/9606.ENSP00000260270Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from a [...]
C11orf1 protein networkhttps://string-db.org/network/9606.ENSP00000260276UPF0686 protein C11orf1; Chromosome 11 open reading frame 1.
ARHGAP20 protein networkhttps://string-db.org/network/9606.ENSP00000260283Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
MMP13 protein networkhttps://string-db.org/network/9606.ENSP00000260302Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type I [...]
UNC13C protein networkhttps://string-db.org/network/9606.ENSP00000260323Protein unc-13 homolog C; May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmi [...]
CTDSPL2 protein networkhttps://string-db.org/network/9606.ENSP00000260327CTD small phosphatase-like protein 2; Probable phosphatase.
THBS1 protein networkhttps://string-db.org/network/9606.ENSP00000260356Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp [...]
NDUFAF1 protein networkhttps://string-db.org/network/9606.ENSP00000260361Complex I intermediate-associated protein 30, mitochondrial; Chaperone protein involved in early stages of the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
KIF23 protein networkhttps://string-db.org/network/9606.ENSP00000260363Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during th [...]
HAUS2 protein networkhttps://string-db.org/network/9606.ENSP00000260372HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
TUBGCP4 protein networkhttps://string-db.org/network/9606.ENSP00000260383Gamma-tubulin complex component 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
RMDN3 protein networkhttps://string-db.org/network/9606.ENSP00000260385Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptos [...]
ITPKA protein networkhttps://string-db.org/network/9606.ENSP00000260386Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family.
PLCB2 protein networkhttps://string-db.org/network/9606.ENSP000002604021-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...]
TMEM62 protein networkhttps://string-db.org/network/9606.ENSP00000260403Transmembrane protein 62.
ADAM10 protein networkhttps://string-db.org/network/9606.ENSP00000260408Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at '76- Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytic [...]
RSL24D1 protein networkhttps://string-db.org/network/9606.ENSP00000260443Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukary [...]
GCHFR protein networkhttps://string-db.org/network/9606.ENSP00000260447GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
MNS1 protein networkhttps://string-db.org/network/9606.ENSP00000260453Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Bel [...]
BCAR3 protein networkhttps://string-db.org/network/9606.ENSP00000260502Breast cancer anti-estrogen resistance protein 3; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fi [...]
TTLL7 protein networkhttps://string-db.org/network/9606.ENSP00000260505Tubulin polyglutamylase TTLL7; Polyglutamylase which preferentially modifies beta-tubulin. Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules. Required for [...]
KYAT3 protein networkhttps://string-db.org/network/9606.ENSP00000260508Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S- [...]
ARHGAP29 protein networkhttps://string-db.org/network/9606.ENSP00000260526Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and [...]
RTCA protein networkhttps://string-db.org/network/9606.ENSP00000260563RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenyl [...]
IFT172 protein networkhttps://string-db.org/network/9606.ENSP00000260570Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the [...]
SELENOI protein networkhttps://string-db.org/network/9606.ENSP00000260585Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP- ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. [...]
KHK protein networkhttps://string-db.org/network/9606.ENSP00000260599Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.
PREB protein networkhttps://string-db.org/network/9606.ENSP00000260643Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat compone [...]
SLC3A1 protein networkhttps://string-db.org/network/9606.ENSP00000260649Neutral and basic amino acid transport protein rBAT; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May [...]
SIX3 protein networkhttps://string-db.org/network/9606.ENSP00000260653Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. Dur [...]
LRPPRC protein networkhttps://string-db.org/network/9606.ENSP00000260665Leucine-rich PPR motif-containing protein, mitochondrial; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of [...]
CYP2C9 protein networkhttps://string-db.org/network/9606.ENSP00000260682Cytochrome P450 2C9; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids. Mechanistically, uses molecular oxygen insert [...]
LOXL4 protein networkhttps://string-db.org/network/9606.ENSP00000260702Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix.
BTBD16 protein networkhttps://string-db.org/network/9606.ENSP00000260723BTB/POZ domain-containing protein 16; BTB domain containing 16.
KIF11 protein networkhttps://string-db.org/network/9606.ENSP00000260731Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to t [...]
CALHM2 protein networkhttps://string-db.org/network/9606.ENSP00000260743Calcium homeostasis modulator protein 2; Pore-forming subunit of a voltage-gated ion channel.
ARL3 protein networkhttps://string-db.org/network/9606.ENSP00000260746ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleoti [...]
EXOC6 protein networkhttps://string-db.org/network/9606.ENSP00000260762Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PR [...]
DBR1 protein networkhttps://string-db.org/network/9606.ENSP00000260803Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently deg [...]
TOPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000260810DNA topoisomerase 2-binding protein 1; Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as [...]
DNAJC13 protein networkhttps://string-db.org/network/9606.ENSP00000260818DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin [...]
GPR87 protein networkhttps://string-db.org/network/9606.ENSP00000260843G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Belongs to the G-protein coupled receptor 1 family.
BARD1 protein networkhttps://string-db.org/network/9606.ENSP00000260947BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diver [...]
MSTN protein networkhttps://string-db.org/network/9606.ENSP00000260950Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.
ASNSD1 protein networkhttps://string-db.org/network/9606.ENSP00000260952Asparagine synthetase domain containing 1.
METTL5 protein networkhttps://string-db.org/network/9606.ENSP00000260953Methyltransferase-like protein 5; Probable methyltransferase.
PPIG protein networkhttps://string-db.org/network/9606.ENSP00000260970Peptidyl-prolyl cis-trans isomerase G; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicat [...]
HECW2 protein networkhttps://string-db.org/network/9606.ENSP00000260983E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regula [...]
CRYGB protein networkhttps://string-db.org/network/9606.ENSP00000260988Gamma-crystallin B; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
CHRNA1 protein networkhttps://string-db.org/network/9606.ENSP00000261007Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...]
WDR12 protein networkhttps://string-db.org/network/9606.ENSP00000261015Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
ITGAV protein networkhttps://string-db.org/network/9606.ENSP00000261023Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, pr [...]
SLC40A1 protein networkhttps://string-db.org/network/9606.ENSP00000261024Solute carrier family 40 member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the pr [...]
COL8A1 protein networkhttps://string-db.org/network/9606.ENSP00000261037Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the en [...]
SLC49A4 protein networkhttps://string-db.org/network/9606.ENSP00000261038Solute carrier family 49 member 4; Electrogenic metabolite transporter. Belongs to the major facilitator superfamily.
GUCA1C protein networkhttps://string-db.org/network/9606.ENSP00000261047Guanylyl cyclase-activating protein 3; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration [...]
CCDC54 protein networkhttps://string-db.org/network/9606.ENSP00000261058Coiled-coil domain containing 54.
COX17 protein networkhttps://string-db.org/network/9606.ENSP00000261070Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two co [...]
WBP11 protein networkhttps://string-db.org/network/9606.ENSP00000261167WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.
GUCY2C protein networkhttps://string-db.org/network/9606.ENSP00000261170Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activa [...]
EPYC protein networkhttps://string-db.org/network/9606.ENSP00000261172Epiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. [...]
TSPAN11 protein networkhttps://string-db.org/network/9606.ENSP00000261177Tetraspanin-11; Tetraspanin 11.
TRHDE protein networkhttps://string-db.org/network/9606.ENSP00000261180Thyrotropin-releasing hormone-degrading ectoenzyme; Specific inactivation of TRH after its release; Belongs to the peptidase M1 family.
OSBPL8 protein networkhttps://string-db.org/network/9606.ENSP00000261183Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylser [...]
INTS13 protein networkhttps://string-db.org/network/9606.ENSP00000261191Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucl [...]
GYS2 protein networkhttps://string-db.org/network/9606.ENSP00000261195Glycogen [starch] synthase, liver; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.
SLCO1B3 protein networkhttps://string-db.org/network/9606.ENSP00000261196Solute carrier organic anion transporter family member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), le [...]
ABCC9 protein networkhttps://string-db.org/network/9606.ENSP00000261200ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore wh [...]
SYT1 protein networkhttps://string-db.org/network/9606.ENSP00000261205Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse (By similarity). May have a regulatory role in the membrane interactions during trafficking [...]
HAL protein networkhttps://string-db.org/network/9606.ENSP00000261208Histidine ammonia-lyase.
CDK17 protein networkhttps://string-db.org/network/9606.ENSP00000261211Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. [...]
TMCC3 protein networkhttps://string-db.org/network/9606.ENSP00000261226Transmembrane and coiled-coil domain family 3; Belongs to the TEX28 family.
IRAK3 protein networkhttps://string-db.org/network/9606.ENSP00000261233Interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or s [...]
RXYLT1 protein networkhttps://string-db.org/network/9606.ENSP00000261234Ribitol-5-phosphate xylosyltransferase 1; UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3- N-acetylglucosamine-bet [...]
MNAT1 protein networkhttps://string-db.org/network/9606.ENSP00000261245CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CD [...]
TRMT5 protein networkhttps://string-db.org/network/9606.ENSP00000261249tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the [...]
C12orf4 protein networkhttps://string-db.org/network/9606.ENSP00000261250Protein C12orf4; Plays a role in mast cell degranulation.
CCND2 protein networkhttps://string-db.org/network/9606.ENSP00000261254G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...]
RAB21 protein networkhttps://string-db.org/network/9606.ENSP00000261263Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may [...]
LYZ protein networkhttps://string-db.org/network/9606.ENSP00000261267Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
FAM189A1 protein networkhttps://string-db.org/network/9606.ENSP00000261275Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family.
LIPG protein networkhttps://string-db.org/network/9606.ENSP00000261292Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hyd [...]
TGDS protein networkhttps://string-db.org/network/9606.ENSP00000261296TDP-glucose 4,6-dehydratase.
PSMC1 protein networkhttps://string-db.org/network/9606.ENSP0000026130326S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
GALC protein networkhttps://string-db.org/network/9606.ENSP00000261304Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible [...]
PPWD1 protein networkhttps://string-db.org/network/9606.ENSP00000261308Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist pro [...]
PEBP1 protein networkhttps://string-db.org/network/9606.ENSP00000261313Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor w [...]
C12orf49 protein networkhttps://string-db.org/network/9606.ENSP00000261318UPF0454 protein C12orf49; Belongs to the UPF0454 family.
MOCOS protein networkhttps://string-db.org/network/9606.ENSP00000261326Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cof [...]
PZP protein networkhttps://string-db.org/network/9606.ENSP00000261336Pregnancy zone protein; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific c [...]
CLEC2D protein networkhttps://string-db.org/network/9606.ENSP00000261340C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulate [...]
LRP6 protein networkhttps://string-db.org/network/9606.ENSP00000261349Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into [...]
LMNB1 protein networkhttps://string-db.org/network/9606.ENSP00000261366Lamin-B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope an [...]
SNCAIP protein networkhttps://string-db.org/network/9606.ENSP00000261367Synphilin-1; Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation o [...]
SNX24 protein networkhttps://string-db.org/network/9606.ENSP00000261369Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
HS3ST2 protein networkhttps://string-db.org/network/9606.ENSP00000261374Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamin [...]
REXO5 protein networkhttps://string-db.org/network/9606.ENSP00000261377RNA exonuclease 5.
XYLT1 protein networkhttps://string-db.org/network/9606.ENSP00000261381Xylosyltransferase 1; Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine [...]
DNAH3 protein networkhttps://string-db.org/network/9606.ENSP00000261383Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
GDE1 protein networkhttps://string-db.org/network/9606.ENSP00000261386Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding [...]
NUP133 protein networkhttps://string-db.org/network/9606.ENSP00000261396Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport. Involved in nephrogenesis.
NUAK1 protein networkhttps://string-db.org/network/9606.ENSP00000261402NUAK family SNF1-like kinase 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progres [...]
VWF protein networkhttps://string-db.org/network/9606.ENSP00000261405Von Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial colla [...]
LPCAT3 protein networkhttps://string-db.org/network/9606.ENSP00000261407Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-gl [...]
HEXB protein networkhttps://string-db.org/network/9606.ENSP00000261416Beta-hexosaminidase subunit beta chain A; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other ti [...]
UBE2K protein networkhttps://string-db.org/network/9606.ENSP00000261427Ubiquitin-conjugating enzyme E2 K; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubi [...]
N4BP2 protein networkhttps://string-db.org/network/9606.ENSP00000261435NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.
KLF3 protein networkhttps://string-db.org/network/9606.ENSP00000261438Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.
TBC1D1 protein networkhttps://string-db.org/network/9606.ENSP00000261439TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the traffickin [...]
RSBN1 protein networkhttps://string-db.org/network/9606.ENSP00000261441Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture.
CASQ2 protein networkhttps://string-db.org/network/9606.ENSP00000261448Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic r [...]
PPP2R5A protein networkhttps://string-db.org/network/9606.ENSP00000261461Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...]
TRAF5 protein networkhttps://string-db.org/network/9606.ENSP00000261464TNF receptor-associated factor 5; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the rec [...]
PPP2R3C protein networkhttps://string-db.org/network/9606.ENSP00000261475Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator [...]
PSMA6 protein networkhttps://string-db.org/network/9606.ENSP00000261479Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
MAN2A1 protein networkhttps://string-db.org/network/9606.ENSP00000261483Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N- [...]
ENOX1 protein networkhttps://string-db.org/network/9606.ENSP00000261488Protein disulfide-thiol oxidoreductase; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone ox [...]
USP22 protein networkhttps://string-db.org/network/9606.ENSP00000261497Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histone [...]
B9D1 protein networkhttps://string-db.org/network/9606.ENSP00000261499B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...]
SPECC1 protein networkhttps://string-db.org/network/9606.ENSP00000261503Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1.
MSMO1 protein networkhttps://string-db.org/network/9606.ENSP00000261507Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.
CLCN3 protein networkhttps://string-db.org/network/9606.ENSP00000261514H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, [...]
ICE2 protein networkhttps://string-db.org/network/9606.ENSP00000261520Little elongation complex subunit 2; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
RORA protein networkhttps://string-db.org/network/9606.ENSP00000261523Nuclear receptor ROR-alpha; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequenc [...]
GPATCH2L protein networkhttps://string-db.org/network/9606.ENSP00000261530G patch domain-containing protein 2-like; G-patch domain containing 2 like.
POMT2 protein networkhttps://string-db.org/network/9606.ENSP00000261534Protein O-mannosyl-transferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, express [...]
MIB1 protein networkhttps://string-db.org/network/9606.ENSP00000261537E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notc [...]
TMEM260 protein networkhttps://string-db.org/network/9606.ENSP00000261556Transmembrane protein 260; Belongs to the TMEM260 family.
AP5M1 protein networkhttps://string-db.org/network/9606.ENSP00000261558AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it may play a role in cell death.
ZNF430 protein networkhttps://string-db.org/network/9606.ENSP00000261560Zinc finger protein 430; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
IPO5 protein networkhttps://string-db.org/network/9606.ENSP00000261574Importin-5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...]
PALB2 protein networkhttps://string-db.org/network/9606.ENSP00000261584Partner and localizer of BRCA2; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand- in [...]
KIAA0556 protein networkhttps://string-db.org/network/9606.ENSP00000261588Protein KIAA0556; May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
DSG2 protein networkhttps://string-db.org/network/9606.ENSP00000261590Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
NOL4 protein networkhttps://string-db.org/network/9606.ENSP00000261592Nucleolar protein 4.
RNF138 protein networkhttps://string-db.org/network/9606.ENSP00000261593E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks [...]
LPIN2 protein networkhttps://string-db.org/network/9606.ENSP00000261596Phosphatidate phosphatase LPIN2; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catal [...]
NDC80 protein networkhttps://string-db.org/network/9606.ENSP00000261597Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Require [...]
THOC1 protein networkhttps://string-db.org/network/9606.ENSP00000261600THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing a [...]
USP14 protein networkhttps://string-db.org/network/9606.ENSP00000261601Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin [...]
HERC2 protein networkhttps://string-db.org/network/9606.ENSP00000261609E3 ubiquitin-protein ligase HERC2; E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in respons [...]
SLC7A5 protein networkhttps://string-db.org/network/9606.ENSP00000261622Large neutral amino acids transporter small subunit 1; The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids suc [...]
CYBA protein networkhttps://string-db.org/network/9606.ENSP00000261623Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively gene [...]
ARL1 protein networkhttps://string-db.org/network/9606.ENSP00000261636ADP-ribosylation factor-like protein 1; GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at t [...]
UTP20 protein networkhttps://string-db.org/network/9606.ENSP00000261637Small subunit processome component 20 homolog; Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.
COX10 protein networkhttps://string-db.org/network/9606.ENSP00000261643Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family.
TTC19 protein networkhttps://string-db.org/network/9606.ENSP00000261647Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological [...]
TNFRSF13B protein networkhttps://string-db.org/network/9606.ENSP00000261652Tumor necrosis factor receptor superfamily member 13B; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent [...]
RIMBP2 protein networkhttps://string-db.org/network/9606.ENSP00000261655RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.
BFAR protein networkhttps://string-db.org/network/9606.ENSP00000261658Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.
KPNA3 protein networkhttps://string-db.org/network/9606.ENSP00000261667Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...]
MPP5 protein networkhttps://string-db.org/network/9606.ENSP00000261681MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells. Also involved in adherens junction biogenesis by ensuring co [...]
CDK2AP1 protein networkhttps://string-db.org/network/9606.ENSP00000261692Cyclin-dependent kinase 2-associated protein 1; specific inhibitor of the cell-cycle kinase CDK2.
SCARB1 protein networkhttps://string-db.org/network/9606.ENSP00000261693Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating sel [...]
RTRAF protein networkhttps://string-db.org/network/9606.ENSP00000261700RNA transcription, translation and transport factor protein; RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and i [...]
SLC6A4 protein networkhttps://string-db.org/network/9606.ENSP00000261707Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin mol [...]
UTP6 protein networkhttps://string-db.org/network/9606.ENSP00000261708U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family.
PSMD11 protein networkhttps://string-db.org/network/9606.ENSP0000026171226S proteasome non-ATPase regulatory subunit 11; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...]
BLMH protein networkhttps://string-db.org/network/9606.ENSP00000261714Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of [...]
TAOK1 protein networkhttps://string-db.org/network/9606.ENSP00000261716Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoske [...]
BTBD1 protein networkhttps://string-db.org/network/9606.ENSP00000261721BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tar [...]
CUX2 protein networkhttps://string-db.org/network/9606.ENSP00000261726Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine [...]
LHX5 protein networkhttps://string-db.org/network/9606.ENSP00000261731LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system.
ALDH2 protein networkhttps://string-db.org/network/9606.ENSP00000261733Aldehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase 2 family member; Belongs to the aldehyde dehydrogenase family.
ERP29 protein networkhttps://string-db.org/network/9606.ENSP00000261735Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possib [...]
ANKRD13A protein networkhttps://string-db.org/network/9606.ENSP00000261739Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...]
NAA25 protein networkhttps://string-db.org/network/9606.ENSP00000261745N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-As [...]
CHRNB4 protein networkhttps://string-db.org/network/9606.ENSP00000261751Neuronal acetylcholine receptor subunit beta-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...]
MESD protein networkhttps://string-db.org/network/9606.ENSP00000261758LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt path [...]
CDH1 protein networkhttps://string-db.org/network/9606.ENSP00000261769Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
AARS1 protein networkhttps://string-db.org/network/9606.ENSP00000261772Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor [...]
VAC14 protein networkhttps://string-db.org/network/9606.ENSP00000261776Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve [...]
TANGO6 protein networkhttps://string-db.org/network/9606.ENSP00000261778Transport and golgi organization 6 homolog.
ARG2 protein networkhttps://string-db.org/network/9606.ENSP00000261783Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regu [...]
TM9SF1 protein networkhttps://string-db.org/network/9606.ENSP00000261789Transmembrane 9 superfamily member 1; Plays an essential role in autophagy. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
IL17B protein networkhttps://string-db.org/network/9606.ENSP00000261796Interleukin-17B; Stimulates the release of tumor necrosis factor alpha and IL- 1-beta from the monocytic cell line THP-1.
NDST1 protein networkhttps://string-db.org/network/9606.ENSP00000261797Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...]
CSNK1A1 protein networkhttps://string-db.org/network/9606.ENSP00000261798Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of [...]
PDGFRB protein networkhttps://string-db.org/network/9606.ENSP00000261799Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays [...]
FAT2 protein networkhttps://string-db.org/network/9606.ENSP00000261800Protocadherin Fat 2; Involved in the regulation of cell migration. May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similari [...]
CYSTM1 protein networkhttps://string-db.org/network/9606.ENSP00000261811Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1.
PFDN1 protein networkhttps://string-db.org/network/9606.ENSP00000261813Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
ANAPC5 protein networkhttps://string-db.org/network/9606.ENSP00000261819Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...]
CYP46A1 protein networkhttps://string-db.org/network/9606.ENSP00000261835Cholesterol 24-hydroxylase; P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholester [...]
GNB5 protein networkhttps://string-db.org/network/9606.ENSP00000261837Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the s [...]
MYO5C protein networkhttps://string-db.org/network/9606.ENSP00000261839Unconventional myosin-Vc; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.
AP4E1 protein networkhttps://string-db.org/network/9606.ENSP00000261842AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. Th [...]
MAPK6 protein networkhttps://string-db.org/network/9606.ENSP00000261845Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still uncle [...]
SPPL2A protein networkhttps://string-db.org/network/9606.ENSP00000261854Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM [...]
GLCE protein networkhttps://string-db.org/network/9606.ENSP00000261858D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is [...]
CORO2B protein networkhttps://string-db.org/network/9606.ENSP00000261861Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family.
SPG11 protein networkhttps://string-db.org/network/9606.ENSP00000261866Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
SLC30A4 protein networkhttps://string-db.org/network/9606.ENSP00000261867Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment; Belongs to the cation diffusion facilitator (CDF) transport [...]
EIF3J protein networkhttps://string-db.org/network/9606.ENSP00000261868Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
HACD3 protein networkhttps://string-db.org/network/9606.ENSP00000261875Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, [...]
APH1B protein networkhttps://string-db.org/network/9606.ENSP00000261879Gamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and [...]
AAGAB protein networkhttps://string-db.org/network/9606.ENSP00000261880Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR.
TIPIN protein networkhttps://string-db.org/network/9606.ENSP00000261881TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replicat [...]
CILP protein networkhttps://string-db.org/network/9606.ENSP00000261883Cartilage intermediate layer protein 1 C1; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced p [...]
TRIP4 protein networkhttps://string-db.org/network/9606.ENSP00000261884Activating signal cointegrator 1; Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factor [...]
PARP16 protein networkhttps://string-db.org/network/9606.ENSP00000261888Protein mono-ADP-ribosyltransferase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those p [...]
SNX1 protein networkhttps://string-db.org/network/9606.ENSP00000261889Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphat [...]
RAB11A protein networkhttps://string-db.org/network/9606.ENSP00000261890Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle be [...]
SLC24A1 protein networkhttps://string-db.org/network/9606.ENSP00000261892Sodium/potassium/calcium exchanger 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapi [...]
LACTB protein networkhttps://string-db.org/network/9606.ENSP00000261893Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mit [...]
CCNT1 protein networkhttps://string-db.org/network/9606.ENSP00000261900Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the tr [...]
HCN4 protein networkhttps://string-db.org/network/9606.ENSP00000261917Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for [...]
SEMA7A protein networkhttps://string-db.org/network/9606.ENSP00000261918Semaphorin-7A; Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activat [...]
LOXL1 protein networkhttps://string-db.org/network/9606.ENSP00000261921Lysyl oxidase homolog 1; Active on elastin and collagen substrates.
FLT4 protein networkhttps://string-db.org/network/9606.ENSP00000261937Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the [...]
FAF2 protein networkhttps://string-db.org/network/9606.ENSP00000261942FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. [...]
TUBGCP3 protein networkhttps://string-db.org/network/9606.ENSP00000261965Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
RBM25 protein networkhttps://string-db.org/network/9606.ENSP00000261973RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isofo [...]
LTBP2 protein networkhttps://string-db.org/network/9606.ENSP00000261978Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family.
VSX2 protein networkhttps://string-db.org/network/9606.ENSP00000261980Visual system homeobox 2; Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters. Plays a significant role in the [...]
SERPINA10 protein networkhttps://string-db.org/network/9606.ENSP00000261994Protein Z-dependent protease inhibitor; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofa [...]
SPAG9 protein networkhttps://string-db.org/network/9606.ENSP00000262013C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...]
SGCA protein networkhttps://string-db.org/network/9606.ENSP00000262018Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
MARS1 protein networkhttps://string-db.org/network/9606.ENSP00000262027Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...]
ATP5F1B protein networkhttps://string-db.org/network/9606.ENSP00000262030ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane w [...]
RBMS2 protein networkhttps://string-db.org/network/9606.ENSP00000262031RNA-binding motif, single-stranded-interacting protein 2; RNA binding motif single stranded interacting protein 2.
PIK3C3 protein networkhttps://string-db.org/network/9606.ENSP00000262039Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to [...]
MEOX2 protein networkhttps://string-db.org/network/9606.ENSP00000262041Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2 [...]
PHF3 protein networkhttps://string-db.org/network/9606.ENSP00000262043PHD finger protein 3.
ATF1 protein networkhttps://string-db.org/network/9606.ENSP00000262053Cyclic AMP-dependent transcription factor ATF-1; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Bi [...]
MMD protein networkhttps://string-db.org/network/9606.ENSP00000262065Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion.
TSPAN13 protein networkhttps://string-db.org/network/9606.ENSP00000262067Tetraspanin-13; Tetraspanin 13.
RAB27B protein networkhttps://string-db.org/network/9606.ENSP00000262094Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis [...]
ZDHHC2 protein networkhttps://string-db.org/network/9606.ENSP00000262096Palmitoyltransferase ZDHHC2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95. Belongs to the DHHC palmitoyltransferase family.
MTUS1 protein networkhttps://string-db.org/network/9606.ENSP00000262102Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces [...]
EFCAB1 protein networkhttps://string-db.org/network/9606.ENSP00000262103EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1.
MCM4 protein networkhttps://string-db.org/network/9606.ENSP00000262105DNA replication licensing factor MCM4; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
ERICH1 protein networkhttps://string-db.org/network/9606.ENSP00000262109Glutamate-rich protein 1; Glutamate rich 1.
MYOM2 protein networkhttps://string-db.org/network/9606.ENSP00000262113Myomesin-2; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
TWSG1 protein networkhttps://string-db.org/network/9606.ENSP00000262120Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs [...]
ANKRD12 protein networkhttps://string-db.org/network/9606.ENSP00000262126Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.
CEP76 protein networkhttps://string-db.org/network/9606.ENSP00000262127Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplic [...]
RBL2 protein networkhttps://string-db.org/network/9606.ENSP00000262133Retinoblastoma-like protein 2; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of con [...]
LPCAT2 protein networkhttps://string-db.org/network/9606.ENSP00000262134Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthes [...]
CACNG4 protein networkhttps://string-db.org/network/9606.ENSP00000262138Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties [...]
WIPI1 protein networkhttps://string-db.org/network/9606.ENSP00000262139WD repeat domain phosphoinositide-interacting protein 1; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged [...]
WDR59 protein networkhttps://string-db.org/network/9606.ENSP00000262144GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC [...]
MTFR1 protein networkhttps://string-db.org/network/9606.ENSP00000262146Mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity).
CDH19 protein networkhttps://string-db.org/network/9606.ENSP00000262150Cadherin-19; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
SMAD7 protein networkhttps://string-db.org/network/9606.ENSP00000262158Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming g [...]
SMAD2 protein networkhttps://string-db.org/network/9606.ENSP00000262160Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth fac [...]
DNAJB6 protein networkhttps://string-db.org/network/9606.ENSP00000262177DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. S [...]
VIPR2 protein networkhttps://string-db.org/network/9606.ENSP00000262178Vasoactive intestinal polypeptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can [...]
KCNH2 protein networkhttps://string-db.org/network/9606.ENSP00000262186Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit ass [...]
RHEB protein networkhttps://string-db.org/network/9606.ENSP00000262187GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through act [...]
SMARCD3 protein networkhttps://string-db.org/network/9606.ENSP00000262188SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...]
KMT2C protein networkhttps://string-db.org/network/9606.ENSP00000262189Histone-lysine N-methyltransferase 2C; Histone methyltransferase that methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. [...]
PSMB1 protein networkhttps://string-db.org/network/9606.ENSP00000262193Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
ADNP2 protein networkhttps://string-db.org/network/9606.ENSP00000262198Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation.
CRISPLD1 protein networkhttps://string-db.org/network/9606.ENSP00000262207Cysteine rich secretory protein LCCL domain containing 1; Belongs to the CRISP family.
TRPA1 protein networkhttps://string-db.org/network/9606.ENSP00000262209Transient receptor potential cation channel subfamily A member 1; Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentra [...]
CSPP1 protein networkhttps://string-db.org/network/9606.ENSP00000262210Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization.
TRAM1 protein networkhttps://string-db.org/network/9606.ENSP00000262213Translocating chain-associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane.
ARFGEF1 protein networkhttps://string-db.org/network/9606.ENSP00000262215Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Invol [...]
ANXA13 protein networkhttps://string-db.org/network/9606.ENSP00000262219Annexin A13; [Isoform A]: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does [...]
TMED2 protein networkhttps://string-db.org/network/9606.ENSP00000262225Transmembrane emp24 domain-containing protein 2; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as car [...]
YY1 protein networkhttps://string-db.org/network/9606.ENSP00000262238Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlappi [...]
RCOR1 protein networkhttps://string-db.org/network/9606.ENSP00000262241REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/ [...]
MOB3B protein networkhttps://string-db.org/network/9606.ENSP00000262244MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promotin [...]
ZNF175 protein networkhttps://string-db.org/network/9606.ENSP00000262259Zinc finger protein 175; Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat-induced viral LTR promoter activity.
CD33 protein networkhttps://string-db.org/network/9606.ENSP00000262262Myeloid cell surface antigen CD33; Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state [...]
PIH1D1 protein networkhttps://string-db.org/network/9606.ENSP00000262265PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enh [...]
SCPEP1 protein networkhttps://string-db.org/network/9606.ENSP00000262288Retinoid-inducible serine carboxypeptidase; May be involved in vascular wall and kidney homeostasis. Belongs to the peptidase S10 family.
LPO protein networkhttps://string-db.org/network/9606.ENSP00000262290Lactoperoxidase; Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to [...]
VMP1 protein networkhttps://string-db.org/network/9606.ENSP00000262291Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization [...]
PRR11 protein networkhttps://string-db.org/network/9606.ENSP00000262293Proline-rich protein 11; Plays a critical role in cell cycle progression.
TRIM37 protein networkhttps://string-db.org/network/9606.ENSP00000262294E3 ubiquitin-protein ligase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediat [...]
PKMYT1 protein networkhttps://string-db.org/network/9606.ENSP00000262300Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specific [...]
LMF1 protein networkhttps://string-db.org/network/9606.ENSP00000262301Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secr [...]
NUBP2 protein networkhttps://string-db.org/network/9606.ENSP00000262302Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP [...]
PKD1 protein networkhttps://string-db.org/network/9606.ENSP00000262304Polycystin-1; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both [...]
RAB11FIP3 protein networkhttps://string-db.org/network/9606.ENSP00000262305Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'addre [...]
ELOB protein networkhttps://string-db.org/network/9606.ENSP00000262306Elongin-B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...]
CHTF18 protein networkhttps://string-db.org/network/9606.ENSP00000262315Chromosome transmission fidelity protein 18 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear [...]
RHBDF1 protein networkhttps://string-db.org/network/9606.ENSP00000262316Inactive rhomboid protein 1; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migr [...]
TELO2 protein networkhttps://string-db.org/network/9606.ENSP00000262319Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kin [...]
AXIN1 protein networkhttps://string-db.org/network/9606.ENSP00000262320Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral pat [...]
RPE65 protein networkhttps://string-db.org/network/9606.ENSP00000262340Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomeriza [...]
IL12RB2 protein networkhttps://string-db.org/network/9606.ENSP00000262345Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as N [...]
SLC1A1 protein networkhttps://string-db.org/network/9606.ENSP00000262352Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cyst [...]
FAM86B2 protein networkhttps://string-db.org/network/9606.ENSP00000262365Putative protein N-methyltransferase FAM86B2; Family with sequence similarity 86 member B2.
GLIS2 protein networkhttps://string-db.org/network/9606.ENSP00000262366Zinc finger protein GLIS2; Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (B [...]
CREBBP protein networkhttps://string-db.org/network/9606.ENSP00000262367CREB-binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non- histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. [...]
MGRN1 protein networkhttps://string-db.org/network/9606.ENSP00000262370E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in th [...]
ALG1 protein networkhttps://string-db.org/network/9606.ENSP00000262374Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyropho [...]
DNAJA3 protein networkhttps://string-db.org/network/9606.ENSP00000262375DnaJ homolog subfamily A member 3, mitochondrial; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria [...]
UBN1 protein networkhttps://string-db.org/network/9606.ENSP00000262376Ubinuclein-1; Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. [...]
N4BP1 protein networkhttps://string-db.org/network/9606.ENSP00000262384NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquiti [...]
WSB1 protein networkhttps://string-db.org/network/9606.ENSP00000262394WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitina [...]
TRAF4 protein networkhttps://string-db.org/network/9606.ENSP00000262395TNF receptor-associated factor 4; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the [...]
RGS9 protein networkhttps://string-db.org/network/9606.ENSP00000262406Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GN [...]
ITGA2B protein networkhttps://string-db.org/network/9606.ENSP00000262407Integrin alpha-IIb light chain, form 1; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R [...]
DHX8 protein networkhttps://string-db.org/network/9606.ENSP00000262415ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. Belongs to th [...]
SLC4A1 protein networkhttps://string-db.org/network/9606.ENSP00000262418Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprot [...]
CRISPLD2 protein networkhttps://string-db.org/network/9606.ENSP00000262424Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family.
FOXF1 protein networkhttps://string-db.org/network/9606.ENSP00000262426Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes.
COTL1 protein networkhttps://string-db.org/network/9606.ENSP00000262428Coactosin-like protein; Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and a [...]
MLYCD protein networkhttps://string-db.org/network/9606.ENSP00000262430Malonyl-CoA decarboxylase, mitochondrial; Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-ma [...]
METTL2B protein networkhttps://string-db.org/network/9606.ENSP00000262432tRNA N(3)-methylcytidine methyltransferase METTL2B; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of [...]
SMURF2 protein networkhttps://string-db.org/network/9606.ENSP00000262435E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...]
GLP2R protein networkhttps://string-db.org/network/9606.ENSP00000262441Glucagon-like peptide 2 receptor; This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
DNAH9 protein networkhttps://string-db.org/network/9606.ENSP00000262442Dynein heavy chain 9, axonemal; Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; th [...]
CHD5 protein networkhttps://string-db.org/network/9606.ENSP00000262450Chromodomain-helicase-DNA-binding protein 5; Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys- [...]
ERP44 protein networkhttps://string-db.org/network/9606.ENSP00000262455Endoplasmic reticulum resident protein 44; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. In [...]
INVS protein networkhttps://string-db.org/network/9606.ENSP00000262457Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt path [...]
GINS1 protein networkhttps://string-db.org/network/9606.ENSP00000262460DNA replication complex GINS protein PSF1; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DN [...]
SLC12A2 protein networkhttps://string-db.org/network/9606.ENSP00000262461Solute carrier family 12 member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume; Belong [...]
SLC27A6 protein networkhttps://string-db.org/network/9606.ENSP00000262462Long-chain fatty acid transport protein 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transpo [...]
RNF167 protein networkhttps://string-db.org/network/9606.ENSP00000262482E3 ubiquitin-protein ligase RNF167; May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin- conjugating enzymes, such as UBE2E [...]
PITPNM3 protein networkhttps://string-db.org/network/9606.ENSP00000262483Membrane-associated phosphatidylinositol transfer protein 3; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ion [...]
ISM1 protein networkhttps://string-db.org/network/9606.ENSP00000262487Isthmin-1; Acts as an angiogenesis inhibitor. Belongs to the isthmin family.
GNAO1 protein networkhttps://string-db.org/network/9606.ENSP00000262494Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G [...]
CFAP20 protein networkhttps://string-db.org/network/9606.ENSP00000262498Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and mor [...]
CSNK2A2 protein networkhttps://string-db.org/network/9606.ENSP00000262506Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C- [...]
COQ9 protein networkhttps://string-db.org/network/9606.ENSP00000262507Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for a [...]
NLRC5 protein networkhttps://string-db.org/network/9606.ENSP00000262510Protein NLRC5; Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of in [...]
SRCAP protein networkhttps://string-db.org/network/9606.ENSP00000262518Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of sel [...]
SETD1A protein networkhttps://string-db.org/network/9606.ENSP00000262519Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if [...]
ZNF629 protein networkhttps://string-db.org/network/9606.ENSP00000262525Zinc finger protein 629; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PCSK2 protein networkhttps://string-db.org/network/9606.ENSP00000262545Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon f [...]
DZANK1 protein networkhttps://string-db.org/network/9606.ENSP00000262547Double zinc ribbon and ankyrin repeat domains 1.
SPTLC1 protein networkhttps://string-db.org/network/9606.ENSP00000262554Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase ( [...]
ZC3H3 protein networkhttps://string-db.org/network/9606.ENSP00000262577Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA [...]
RPL8 protein networkhttps://string-db.org/network/9606.ENSP0000026258460S ribosomal protein L8; Component of the large ribosomal subunit.
DOK5 protein networkhttps://string-db.org/network/9606.ENSP00000262593Docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in [...]
SLC9A3R1 protein networkhttps://string-db.org/network/9606.ENSP00000262613Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the acti [...]
CHST8 protein networkhttps://string-db.org/network/9606.ENSP00000262622Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesi [...]
ATP4A protein networkhttps://string-db.org/network/9606.ENSP00000262623Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the sto [...]
HPN protein networkhttps://string-db.org/network/9606.ENSP00000262626Serine protease hepsin non-catalytic chain; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Play [...]
TYROBP protein networkhttps://string-db.org/network/9606.ENSP00000262629TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and [...]
RBM42 protein networkhttps://string-db.org/network/9606.ENSP00000262633RNA-binding protein 42; Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.
VAMP7 protein networkhttps://string-db.org/network/9606.ENSP00000262640Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. [...]
CCNE1 protein networkhttps://string-db.org/network/9606.ENSP00000262643G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition.
IMPAD1 protein networkhttps://string-db.org/network/9606.ENSP00000262644Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adeno [...]
RAB2A protein networkhttps://string-db.org/network/9606.ENSP00000262646Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex.
ANOS1 protein networkhttps://string-db.org/network/9606.ENSP00000262648Anosmin-1; Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Che [...]
CBFA2T2 protein networkhttps://string-db.org/network/9606.ENSP00000262653Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...]
CCM2L protein networkhttps://string-db.org/network/9606.ENSP00000262659Cerebral cavernous malformations 2 protein-like; CCM2 like scaffold protein.
CDKN2C protein networkhttps://string-db.org/network/9606.ENSP00000262662Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; [...]
ACIN1 protein networkhttps://string-db.org/network/9606.ENSP00000262710Apoptotic chromatin condensation inducer in the nucleus; Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a [...]
AJUBA protein networkhttps://string-db.org/network/9606.ENSP00000262713LIM domain-containing protein ajuba; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate d [...]
TEP1 protein networkhttps://string-db.org/network/9606.ENSP00000262715Telomerase protein component 1; Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults p [...]
CDH20 protein networkhttps://string-db.org/network/9606.ENSP00000262717Cadherin-20; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
PHLPP1 protein networkhttps://string-db.org/network/9606.ENSP00000262719PH domain leucine-rich repeat-containing protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobi [...]
EFCAB6 protein networkhttps://string-db.org/network/9606.ENSP00000262726EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogati [...]
CELSR1 protein networkhttps://string-db.org/network/9606.ENSP00000262738Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation.
PIK3R3 protein networkhttps://string-db.org/network/9606.ENSP00000262741Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin sti [...]
PRDX1 protein networkhttps://string-db.org/network/9606.ENSP00000262746Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...]
RPS6KA6 protein networkhttps://string-db.org/network/9606.ENSP00000262752Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent c [...]
PGS1 protein networkhttps://string-db.org/network/9606.ENSP00000262764CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the [...]
QRICH2 protein networkhttps://string-db.org/network/9606.ENSP00000262765Glutamine-rich protein 2; Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins invo [...]
TIMP2 protein networkhttps://string-db.org/network/9606.ENSP00000262768Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2 [...]
LGALS3BP protein networkhttps://string-db.org/network/9606.ENSP00000262776Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
MOV10L1 protein networkhttps://string-db.org/network/9606.ENSP00000262794RNA helicase Mov10l1; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts v [...]
ELL protein networkhttps://string-db.org/network/9606.ENSP00000262809RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by [...]
MAST3 protein networkhttps://string-db.org/network/9606.ENSP00000262811Microtubule associated serine/threonine kinase 3.
MAU2 protein networkhttps://string-db.org/network/9606.ENSP00000262815MAU2 chromatid cohesion factor homolog; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/S [...]
TRPC5 protein networkhttps://string-db.org/network/9606.ENSP00000262839Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...]
MID2 protein networkhttps://string-db.org/network/9606.ENSP00000262843Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization. Belongs to the TRIM/RBCC family.
AMMECR1 protein networkhttps://string-db.org/network/9606.ENSP00000262844AMMECR nuclear protein 1.
PRKX protein networkhttps://string-db.org/network/9606.ENSP00000262848cAMP-dependent protein kinase catalytic subunit PRKX; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that m [...]
RRAGB protein networkhttps://string-db.org/network/9606.ENSP00000262850Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling casc [...]
BPI protein networkhttps://string-db.org/network/9606.ENSP00000262865Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very [...]
SLA2 protein networkhttps://string-db.org/network/9606.ENSP00000262866Src-like-adapter 2; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May ac [...]
RALGAPB protein networkhttps://string-db.org/network/9606.ENSP00000262879Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
XRCC1 protein networkhttps://string-db.org/network/9606.ENSP00000262887DNA repair protein XRCC1; Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose l [...]
MARK4 protein networkhttps://string-db.org/network/9606.ENSP00000262891MAP/microtubule affinity-regulating kinase 4; Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT/TAU. Also phosphorylates the microtubule-associated proteins [...]
ZNF225 protein networkhttps://string-db.org/network/9606.ENSP00000262894Zinc finger protein 225; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HACE1 protein networkhttps://string-db.org/network/9606.ENSP00000262903E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cy [...]
E2F3 protein networkhttps://string-db.org/network/9606.ENSP00000262904Transcription factor E2F3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of gen [...]
KCNQ4 protein networkhttps://string-db.org/network/9606.ENSP00000262916Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of [...]
ATRN protein networkhttps://string-db.org/network/9606.ENSP00000262919Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that [...]
CNPY4 protein networkhttps://string-db.org/network/9606.ENSP00000262932Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4.
RASA4 protein networkhttps://string-db.org/network/9606.ENSP00000262940Ras GTPase-activating protein 4; Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an a [...]
ARPC1A protein networkhttps://string-db.org/network/9606.ENSP00000262942Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleat [...]
MYDGF protein networkhttps://string-db.org/network/9606.ENSP00000262947Myeloid-derived growth factor; Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair afte [...]
MAP2K2 protein networkhttps://string-db.org/network/9606.ENSP00000262948Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activ [...]
GNA15 protein networkhttps://string-db.org/network/9606.ENSP00000262958Guanine nucleotide-binding protein subunit alpha-15; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
DPP9 protein networkhttps://string-db.org/network/9606.ENSP00000262960Dipeptidyl peptidase 9; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.
ZFR2 protein networkhttps://string-db.org/network/9606.ENSP00000262961Zinc finger RNA binding protein 2.
YJU2 protein networkhttps://string-db.org/network/9606.ENSP00000262962Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the [...]
TCF3 protein networkhttps://string-db.org/network/9606.ENSP00000262965Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) prote [...]
PIAS4 protein networkhttps://string-db.org/network/9606.ENSP00000262971E3 SUMO-protein ligase PIAS4; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...]
CSE1L protein networkhttps://string-db.org/network/9606.ENSP00000262982Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In th [...]
ZNF330 protein networkhttps://string-db.org/network/9606.ENSP00000262990Zinc finger protein 330.
GAB1 protein networkhttps://string-db.org/network/9606.ENSP00000262995GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably in [...]
UCP1 protein networkhttps://string-db.org/network/9606.ENSP00000262999Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non- [...]
MAPK3 protein networkhttps://string-db.org/network/9606.ENSP00000263025Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which pla [...]
EEF2K protein networkhttps://string-db.org/network/9606.ENSP00000263026Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases incl [...]
DHTKD1 protein networkhttps://string-db.org/network/9606.ENSP00000263035Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It [...]
PHYH protein networkhttps://string-db.org/network/9606.ENSP00000263038Phytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA.
SORCS1 protein networkhttps://string-db.org/network/9606.ENSP00000263054Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily.
MAP3K8 protein networkhttps://string-db.org/network/9606.ENSP00000263056Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for productio [...]
EPC1 protein networkhttps://string-db.org/network/9606.ENSP00000263062Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleos [...]
MTPAP protein networkhttps://string-db.org/network/9606.ENSP00000263063Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). [...]
SCARF1 protein networkhttps://string-db.org/network/9606.ENSP00000263071Scavenger receptor class F member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion pro [...]
SMG6 protein networkhttps://string-db.org/network/9606.ENSP00000263073Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regu [...]
ASPA protein networkhttps://string-db.org/network/9606.ENSP00000263080Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant [...]
DPH1 protein networkhttps://string-db.org/network/9606.ENSP000002630832-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation el [...]
ITGAE protein networkhttps://string-db.org/network/9606.ENSP00000263087Integrin alpha-E heavy chain; Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.
PLD2 protein networkhttps://string-db.org/network/9606.ENSP00000263088Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
METTL16 protein networkhttps://string-db.org/network/9606.ENSP00000263092RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeos [...]
SLC27A5 protein networkhttps://string-db.org/network/9606.ENSP00000263093Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycin [...]
ABCA7 protein networkhttps://string-db.org/network/9606.ENSP00000263094Phospholipid-transporting ATPase ABCA7; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of AT [...]
ZNF264 protein networkhttps://string-db.org/network/9606.ENSP00000263095Zinc finger protein 264; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
A1BG protein networkhttps://string-db.org/network/9606.ENSP00000263100Alpha-1B-glycoprotein; alpha-1-B glycoprotein.
CCDC6 protein networkhttps://string-db.org/network/9606.ENSP00000263102Coiled-coil domain containing 6.
RAB36 protein networkhttps://string-db.org/network/9606.ENSP00000263116Ras-related protein Rab-36; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
PRKCQ protein networkhttps://string-db.org/network/9606.ENSP00000263125Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) [...]
WDR37 protein networkhttps://string-db.org/network/9606.ENSP00000263150WD repeat domain 37.
SLC17A6 protein networkhttps://string-db.org/network/9606.ENSP00000263160Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...]
CAPZA1 protein networkhttps://string-db.org/network/9606.ENSP00000263168F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...]
PALMD protein networkhttps://string-db.org/network/9606.ENSP00000263174Palmdelphin.
PLPPR5 protein networkhttps://string-db.org/network/9606.ENSP00000263177Phospholipid phosphatase-related protein type 5; Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retractio [...]
KIF18A protein networkhttps://string-db.org/network/9606.ENSP00000263181Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement du [...]
BBOX1 protein networkhttps://string-db.org/network/9606.ENSP00000263182Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family.
MSH4 protein networkhttps://string-db.org/network/9606.ENSP00000263187MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair Mu [...]
DGCR2 protein networkhttps://string-db.org/network/9606.ENSP00000263196Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell- cell or cell-matrix interactions required for normal cell differentiation and migration.
UFD1 protein networkhttps://string-db.org/network/9606.ENSP00000263202Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary compl [...]
MED15 protein networkhttps://string-db.org/network/9606.ENSP00000263205Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
ARVCF protein networkhttps://string-db.org/network/9606.ENSP00000263207Armadillo repeat protein deleted in velo-cardio-facial syndrome; Involved in protein-protein interactions at adherens junctions; Belongs to the beta-catenin family.
HIRA protein networkhttps://string-db.org/network/9606.ENSP00000263208Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for t [...]
DGCR8 protein networkhttps://string-db.org/network/9606.ENSP00000263209Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Com [...]
PPM1F protein networkhttps://string-db.org/network/9606.ENSP00000263212Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kina [...]
UBE2R2 protein networkhttps://string-db.org/network/9606.ENSP00000263228Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyub [...]
SYP protein networkhttps://string-db.org/network/9606.ENSP00000263233Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and [...]
ACTR3 protein networkhttps://string-db.org/network/9606.ENSP00000263238Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 c [...]
DDX18 protein networkhttps://string-db.org/network/9606.ENSP00000263239ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
ARFGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000263245ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from G [...]
PACSIN2 protein networkhttps://string-db.org/network/9606.ENSP00000263246Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubul [...]
EP300 protein networkhttps://string-db.org/network/9606.ENSP00000263253Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation [...]
DESI1 protein networkhttps://string-db.org/network/9606.ENSP00000263256Desumoylating isopeptidase 1; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB [...]
NOVA2 protein networkhttps://string-db.org/network/9606.ENSP00000263257RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA.
PLEKHA4 protein networkhttps://string-db.org/network/9606.ENSP00000263265Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
FAM83E protein networkhttps://string-db.org/network/9606.ENSP00000263266Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family.
MREG protein networkhttps://string-db.org/network/9606.ENSP00000263268Melanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of [...]
GRIN2D protein networkhttps://string-db.org/network/9606.ENSP00000263269Glutamate receptor ionotropic, NMDA 2D; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...]
LIG1 protein networkhttps://string-db.org/network/9606.ENSP00000263274DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
EHD2 protein networkhttps://string-db.org/network/9606.ENSP00000263277EH domain-containing protein 2; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking betwee [...]
HSD17B14 protein networkhttps://string-db.org/network/9606.ENSP0000026327817-beta-hydroxysteroid dehydrogenase 14; Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestra [...]
LY9 protein networkhttps://string-db.org/network/9606.ENSP00000263285T-lymphocyte surface antigen Ly-9; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are [...]
P2RX3 protein networkhttps://string-db.org/network/9606.ENSP00000263314P2X purinoceptor 3; Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception ( [...]
NOX4 protein networkhttps://string-db.org/network/9606.ENSP00000263317NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases in [...]
TYR protein networkhttps://string-db.org/network/9606.ENSP00000263321Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the [...]
IL37 protein networkhttps://string-db.org/network/9606.ENSP00000263326Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine p [...]
PAX8 protein networkhttps://string-db.org/network/9606.ENSP00000263334Paired box protein Pax-8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such [...]
IL1A protein networkhttps://string-db.org/network/9606.ENSP00000263339Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activit [...]
IL1B protein networkhttps://string-db.org/network/9606.ENSP00000263341Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and [...]
TCF25 protein networkhttps://string-db.org/network/9606.ENSP00000263346Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart develo [...]
NAPA protein networkhttps://string-db.org/network/9606.ENSP00000263354Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plas [...]
BLVRB protein networkhttps://string-db.org/network/9606.ENSP00000263368Flavin reductase (NADPH); Broad specificity oxidoreductase that catalyzes the NADPH- dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQ [...]
ITPKC protein networkhttps://string-db.org/network/9606.ENSP00000263370Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family.
KCNK6 protein networkhttps://string-db.org/network/9606.ENSP00000263372Potassium channel subfamily K member 6; Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions; Belongs to the two pore domai [...]
BRD4 protein networkhttps://string-db.org/network/9606.ENSP00000263377Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transc [...]
IL27RA protein networkhttps://string-db.org/network/9606.ENSP00000263379Interleukin-27 receptor subunit alpha; Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in [...]
ASF1B protein networkhttps://string-db.org/network/9606.ENSP00000263382Histone chaperone ASF1B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly fact [...]
ILVBL protein networkhttps://string-db.org/network/9606.ENSP00000263383Acetolactate synthase-like protein; ilvB acetolactate synthase like.
FAM32A protein networkhttps://string-db.org/network/9606.ENSP00000263384Protein FAM32A; Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
NOTCH3 protein networkhttps://string-db.org/network/9606.ENSP00000263388Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...]
MED26 protein networkhttps://string-db.org/network/9606.ENSP00000263390Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
COMMD9 protein networkhttps://string-db.org/network/9606.ENSP00000263401COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. Modulates Na(+) transport in epithelial ce [...]
C9 protein networkhttps://string-db.org/network/9606.ENSP00000263408Complement component C9a; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells [...]
C6 protein networkhttps://string-db.org/network/9606.ENSP00000263413Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
PRKCG protein networkhttps://string-db.org/network/9606.ENSP00000263431Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such [...]
PPP1R12C protein networkhttps://string-db.org/network/9606.ENSP00000263433Protein phosphatase 1 regulatory subunit 12C; Regulates myosin phosphatase activity.
ALG6 protein networkhttps://string-db.org/network/9606.ENSP00000263440Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from d [...]
WDR11 protein networkhttps://string-db.org/network/9606.ENSP00000263461WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transc [...]
BIRC3 protein networkhttps://string-db.org/network/9606.ENSP00000263464Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase sig [...]
CEP126 protein networkhttps://string-db.org/network/9606.ENSP00000263468Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation.
SLC10A3 protein networkhttps://string-db.org/network/9606.ENSP00000263512P3 protein; The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
ATP2B3 protein networkhttps://string-db.org/network/9606.ENSP00000263519Plasma membrane calcium-transporting ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
PARP12 protein networkhttps://string-db.org/network/9606.ENSP00000263549Protein mono-ADP-ribosyltransferase PARP12; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins.
P4HA1 protein networkhttps://string-db.org/network/9606.ENSP00000263556Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.
VPS26A protein networkhttps://string-db.org/network/9606.ENSP00000263559Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...]
PALD1 protein networkhttps://string-db.org/network/9606.ENSP00000263563Paladin; Phosphatase domain containing paladin 1.
DDX25 protein networkhttps://string-db.org/network/9606.ENSP00000263576ATP-dependent RNA helicase DDX25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity).
FOXRED1 protein networkhttps://string-db.org/network/9606.ENSP00000263578FAD-dependent oxidoreductase domain-containing protein 1; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of [...]
DCPS protein networkhttps://string-db.org/network/9606.ENSP00000263579m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hyd [...]
SIAE protein networkhttps://string-db.org/network/9606.ENSP00000263593Sialate O-acetylesterase; Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid.
LCN1 protein networkhttps://string-db.org/network/9606.ENSP00000263598Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical struct [...]
BARHL1 protein networkhttps://string-db.org/network/9606.ENSP00000263610BarH like homeobox 1.
ARID3A protein networkhttps://string-db.org/network/9606.ENSP00000263620AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
MTIF2 protein networkhttps://string-db.org/network/9606.ENSP00000263629Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes [...]
TANC1 protein networkhttps://string-db.org/network/9606.ENSP00000263635Protein TANC1; May be a scaffold component in the postsynaptic density.
LY75 protein networkhttps://string-db.org/network/9606.ENSP00000263636Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proli [...]
CD81 protein networkhttps://string-db.org/network/9606.ENSP00000263645CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential [...]
OSBPL5 protein networkhttps://string-db.org/network/9606.ENSP00000263650Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylser [...]
CNRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000263655CB1 cannabinoid receptor-interacting protein 1; [Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Belongs to the CNRIP family.
PNO1 protein networkhttps://string-db.org/network/9606.ENSP00000263657RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA.
TAF1B protein networkhttps://string-db.org/network/9606.ENSP00000263663TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple st [...]
CNTN3 protein networkhttps://string-db.org/network/9606.ENSP00000263665Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfami [...]
PDZRN3 protein networkhttps://string-db.org/network/9606.ENSP00000263666E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its en [...]
CHRDL2 protein networkhttps://string-db.org/network/9606.ENSP00000263671Chordin-like protein 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesench [...]
SPCS2 protein networkhttps://string-db.org/network/9606.ENSP00000263672Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endopla [...]
ARHGEF17 protein networkhttps://string-db.org/network/9606.ENSP00000263674Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
POLD3 protein networkhttps://string-db.org/network/9606.ENSP00000263681DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delt [...]
SELP protein networkhttps://string-db.org/network/9606.ENSP00000263686P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocy [...]
SNRNP40 protein networkhttps://string-db.org/network/9606.ENSP00000263694U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex an [...]
DNAJC8 protein networkhttps://string-db.org/network/9606.ENSP00000263697DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells.
MECR protein networkhttps://string-db.org/network/9606.ENSP00000263702Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fa [...]
TFCP2L1 protein networkhttps://string-db.org/network/9606.ENSP00000263707Transcription factor CP2-like protein 1; Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector [...]
PTPN4 protein networkhttps://string-db.org/network/9606.ENSP00000263708Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting n [...]
CLASP1 protein networkhttps://string-db.org/network/9606.ENSP00000263710CLIP-associating protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating fr [...]
EPB41L5 protein networkhttps://string-db.org/network/9606.ENSP00000263713Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells.
LHX4 protein networkhttps://string-db.org/network/9606.ENSP00000263726LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DN [...]
FAM20B protein networkhttps://string-db.org/network/9606.ENSP00000263733Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG cha [...]
EPAS1 protein networkhttps://string-db.org/network/9606.ENSP00000263734Endothelial PAS domain-containing protein 1; Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG- [...]
EPCAM protein networkhttps://string-db.org/network/9606.ENSP00000263735Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epitheliu [...]
SRBD1 protein networkhttps://string-db.org/network/9606.ENSP00000263736S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1.
SGO1 protein networkhttps://string-db.org/network/9606.ENSP00000263753Shugoshin 1; Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex disso [...]
KAT2B protein networkhttps://string-db.org/network/9606.ENSP00000263754Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 an [...]
FNBP4 protein networkhttps://string-db.org/network/9606.ENSP00000263773Formin binding protein 4.
NDUFS3 protein networkhttps://string-db.org/network/9606.ENSP00000263774NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...]
ACCS protein networkhttps://string-db.org/network/9606.ENSP000002637761-aminocyclopropane-1-carboxylate synthase-like protein 1; Does not catalyze the synthesis of 1-aminocyclopropane-1- carboxylate but is capable of catalyzing the deamination of L- vinylglycine.
CHMP2B protein networkhttps://string-db.org/network/9606.ENSP00000263780Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
EIF2AK4 protein networkhttps://string-db.org/network/9606.ENSP00000263791eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' in response [...]
WDR76 protein networkhttps://string-db.org/network/9606.ENSP00000263795WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC; Belongs to the WD repeat DDB2/WDR76 family.
TYRO3 protein networkhttps://string-db.org/network/9606.ENSP00000263798Tyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Re [...]
LTK protein networkhttps://string-db.org/network/9606.ENSP00000263800Leukocyte tyrosine kinase receptor; Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular [...]
ZNF106 protein networkhttps://string-db.org/network/9606.ENSP00000263805Zinc finger protein 106; RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Requir [...]
OSBP protein networkhttps://string-db.org/network/9606.ENSP00000263847Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphat [...]
ZC2HC1A protein networkhttps://string-db.org/network/9606.ENSP00000263849Zinc finger C2HC-type containing 1A.
IL7 protein networkhttps://string-db.org/network/9606.ENSP00000263851Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
CHMP3 protein networkhttps://string-db.org/network/9606.ENSP00000263856Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
POLR1A protein networkhttps://string-db.org/network/9606.ENSP00000263857DNA-directed RNA polymerase I subunit RPA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalyt [...]
VAMP8 protein networkhttps://string-db.org/network/9606.ENSP00000263864Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on [...]
CAPG protein networkhttps://string-db.org/network/9606.ENSP00000263867Macrophage-capping protein; Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrop [...]
MAP4K3 protein networkhttps://string-db.org/network/9606.ENSP00000263881Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Belongs to the protein kin [...]
USE1 protein networkhttps://string-db.org/network/9606.ENSP00000263897Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER.
STAM2 protein networkhttps://string-db.org/network/9606.ENSP00000263904Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leadi [...]
GRB14 protein networkhttps://string-db.org/network/9606.ENSP00000263915Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the act [...]
STRN protein networkhttps://string-db.org/network/9606.ENSP00000263918Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family.
CHIC2 protein networkhttps://string-db.org/network/9606.ENSP00000263921Cysteine-rich hydrophobic domain-containing protein 2; Cysteine rich hydrophobic domain 2; Belongs to the CHIC family.
KDR protein networkhttps://string-db.org/network/9606.ENSP00000263923Vascular endothelial growth factor receptor 2; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, [...]
LNX1 protein networkhttps://string-db.org/network/9606.ENSP00000263925E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquiti [...]
TNFRSF8 protein networkhttps://string-db.org/network/9606.ENSP00000263932Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene e [...]
KIF1B protein networkhttps://string-db.org/network/9606.ENSP00000263934Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.
PKP1 protein networkhttps://string-db.org/network/9606.ENSP00000263946Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
STK17B protein networkhttps://string-db.org/network/9606.ENSP00000263955Serine/threonine-protein kinase 17B; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.
GTF3C3 protein networkhttps://string-db.org/network/9606.ENSP00000263956General transcription factor 3C polypeptide 3; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...]
COQ10B protein networkhttps://string-db.org/network/9606.ENSP00000263960Coenzyme Q-binding protein COQ10 homolog B, mitochondrial; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 fro [...]
USP13 protein networkhttps://string-db.org/network/9606.ENSP00000263966Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autopha [...]
PIK3CA protein networkhttps://string-db.org/network/9606.ENSP00000263967Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol [...]
TAF12 protein networkhttps://string-db.org/network/9606.ENSP00000263974Transcription initiation factor TFIID subunit 12; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs compo [...]
SLC9A1 protein networkhttps://string-db.org/network/9606.ENSP00000263980Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
GATB protein networkhttps://string-db.org/network/9606.ENSP00000263985Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...]
EHBP1 protein networkhttps://string-db.org/network/9606.ENSP00000263991EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle tr [...]
SLC7A6OS protein networkhttps://string-db.org/network/9606.ENSP00000263997Probable RNA polymerase II nuclear localization protein SLC7A6OS; Directs RNA polymerase II nuclear import.
CKLF protein networkhttps://string-db.org/network/9606.ENSP00000264001Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.
LCAT protein networkhttps://string-db.org/network/9606.ENSP00000264005Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts chole [...]
CDH3 protein networkhttps://string-db.org/network/9606.ENSP00000264012Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
IFT46 protein networkhttps://string-db.org/network/9606.ENSP00000264020Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance an [...]
NECTIN1 protein networkhttps://string-db.org/network/9606.ENSP00000264025Nectin-1; Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. [...]
SC5D protein networkhttps://string-db.org/network/9606.ENSP00000264027Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family.
ARCN1 protein networkhttps://string-db.org/network/9606.ENSP00000264028Coatomer subunit delta; Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further medi [...]
TREH protein networkhttps://string-db.org/network/9606.ENSP00000264029Trehalase; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
UPK2 protein networkhttps://string-db.org/network/9606.ENSP00000264031Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating t [...]
CBL protein networkhttps://string-db.org/network/9606.ENSP00000264033E3 ubiquitin-protein ligase CBL; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiqui [...]
MCAM protein networkhttps://string-db.org/network/9606.ENSP00000264036Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells [...]
GPC1 protein networkhttps://string-db.org/network/9606.ENSP00000264039Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By simila [...]
FARP2 protein networkhttps://string-db.org/network/9606.ENSP00000264042FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to cla [...]
SLC5A7 protein networkhttps://string-db.org/network/9606.ENSP00000264047High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in ac [...]
NGEF protein networkhttps://string-db.org/network/9606.ENSP00000264051Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone [...]
DGKD protein networkhttps://string-db.org/network/9606.ENSP00000264057Diacylglycerol kinase delta; May function as signaling molecule.
EFHD1 protein networkhttps://string-db.org/network/9606.ENSP00000264059EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production. May play a rol [...]
DNAJC10 protein networkhttps://string-db.org/network/9606.ENSP00000264065DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient foldin [...]
TUBB4A protein networkhttps://string-db.org/network/9606.ENSP00000264071Tubulin beta-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...]
FCER2 protein networkhttps://string-db.org/network/9606.ENSP00000264072Low affinity immunoglobulin epsilon Fc receptor membrane-bound form; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in [...]
MCOLN1 protein networkhttps://string-db.org/network/9606.ENSP00000264079Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from la [...]
GPR108 protein networkhttps://string-db.org/network/9606.ENSP00000264080G protein-coupled receptor 108.
DGUOK protein networkhttps://string-db.org/network/9606.ENSP00000264093Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where [...]
LOXL3 protein networkhttps://string-db.org/network/9606.ENSP00000264094Lysyl oxidase homolog 3; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of [...]
HAT1 protein networkhttps://string-db.org/network/9606.ENSP00000264108Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at [...]
ATF2 protein networkhttps://string-db.org/network/9606.ENSP00000264110Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA dam [...]
LAMC2 protein networkhttps://string-db.org/network/9606.ENSP00000264144Laminin subunit gamma-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
OSGEPL1 protein networkhttps://string-db.org/network/9606.ENSP00000264151Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that r [...]
MCM6 protein networkhttps://string-db.org/network/9606.ENSP00000264156DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
CCNT2 protein networkhttps://string-db.org/network/9606.ENSP00000264157Cyclin-T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the tra [...]
ZRANB3 protein networkhttps://string-db.org/network/9606.ENSP00000264159DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restar [...]
DARS1 protein networkhttps://string-db.org/network/9606.ENSP00000264161Aspartate--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...]
LCT protein networkhttps://string-db.org/network/9606.ENSP00000264162Lactase-phlorizin hydrolase; LPH splits lactose in the small intestine.
AGPS protein networkhttps://string-db.org/network/9606.ENSP00000264167Alkyldihydroxyacetonephosphate synthase, peroxisomal; Catalyzes the exchange of the acyl chain in acyl- dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first et [...]
KYNU protein networkhttps://string-db.org/network/9606.ENSP00000264170Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preferen [...]
ARID4B protein networkhttps://string-db.org/network/9606.ENSP00000264183AT-rich interactive domain-containing protein 4B; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating inte [...]
NID1 protein networkhttps://string-db.org/network/9606.ENSP00000264187Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular [...]
CYTIP protein networkhttps://string-db.org/network/9606.ENSP00000264192Cytohesin-interacting protein; By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.
MUL1 protein networkhttps://string-db.org/network/9606.ENSP00000264198Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form o [...]
NMU protein networkhttps://string-db.org/network/9606.ENSP00000264218Neuromedin precursor-related peptide 33; [Neuromedin-U-25]: Ligand for receptors NMUR1 and NMUR2 (By similarity). Stimulates muscle contractions of specific regions of the gastrointestinal tract. [...]
PPAT protein networkhttps://string-db.org/network/9606.ENSP00000264220Amidophosphoribosyltransferase; Phosphoribosyl pyrophosphate amidotransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
SRD5A3 protein networkhttps://string-db.org/network/9606.ENSP00000264228Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis [...]
CRACD protein networkhttps://string-db.org/network/9606.ENSP00000264229Capping protein inhibiting regulator of actin dynamics; Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization [...]
NOA1 protein networkhttps://string-db.org/network/9606.ENSP00000264230Nitric oxide-associated protein 1; Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein [...]
POPDC2 protein networkhttps://string-db.org/network/9606.ENSP00000264231Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, pro [...]
POLQ protein networkhttps://string-db.org/network/9606.ENSP00000264233DNA polymerase theta; DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand br [...]
UPK1B protein networkhttps://string-db.org/network/9606.ENSP00000264234Uroplakin-1b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal blad [...]
ARHGAP31 protein networkhttps://string-db.org/network/9606.ENSP00000264245Rho GTPase-activating protein 31; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.
CD80 protein networkhttps://string-db.org/network/9606.ENSP00000264246T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, [...]
CHST10 protein networkhttps://string-db.org/network/9606.ENSP00000264249Carbohydrate sulfotransferase 10; Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of H [...]
PDCL3 protein networkhttps://string-db.org/network/9606.ENSP00000264254Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity [...]
TXNDC9 protein networkhttps://string-db.org/network/9606.ENSP00000264255Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin.
IL1RL2 protein networkhttps://string-db.org/network/9606.ENSP00000264257Interleukin-1 receptor-like 2; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor comp [...]
IL18RAP protein networkhttps://string-db.org/network/9606.ENSP00000264260Interleukin-18 receptor accessory protein; Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK acti [...]
GFM1 protein networkhttps://string-db.org/network/9606.ENSP00000264263Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from t [...]
LXN protein networkhttps://string-db.org/network/9606.ENSP00000264265Latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. Belongs to the protease inhibitor I47 (latexin) family.
ALS2 protein networkhttps://string-db.org/network/9606.ENSP00000264276Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity).
NOP58 protein networkhttps://string-db.org/network/9606.ENSP00000264279Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of [...]
SLAIN2 protein networkhttps://string-db.org/network/9606.ENSP00000264313SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation [...]
TXK protein networkhttps://string-db.org/network/9606.ENSP00000264316Tyrosine-protein kinase TXK; Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiati [...]
GABRA4 protein networkhttps://string-db.org/network/9606.ENSP00000264318Gamma-aminobutyric acid receptor subunit alpha-4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
TOP2B protein networkhttps://string-db.org/network/9606.ENSP00000264331DNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks; Belongs to the type II [...]
YWHAE protein networkhttps://string-db.org/network/9606.ENSP0000026433514-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recogn [...]
FAM13A protein networkhttps://string-db.org/network/9606.ENSP00000264344Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family.
HERC6 protein networkhttps://string-db.org/network/9606.ENSP00000264346Probable E3 ubiquitin-protein ligase HERC6; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...]
HERC5 protein networkhttps://string-db.org/network/9606.ENSP00000264350E3 ISG15--protein ligase HERC5; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylatio [...]
PCDH10 protein networkhttps://string-db.org/network/9606.ENSP00000264360Protocadherin-10; Potential calcium-dependent cell-adhesion protein.
NDST4 protein networkhttps://string-db.org/network/9606.ENSP00000264363Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...]
CRYGD protein networkhttps://string-db.org/network/9606.ENSP00000264376Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens.
ADAM23 protein networkhttps://string-db.org/network/9606.ENSP00000264377Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
PIKFYVE protein networkhttps://string-db.org/network/9606.ENSP000002643801-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the pho [...]
BCHE protein networkhttps://string-db.org/network/9606.ENSP00000264381Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the typ [...]
SI protein networkhttps://string-db.org/network/9606.ENSP00000264382Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs t [...]
PRKG2 protein networkhttps://string-db.org/network/9606.ENSP00000264399cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestina [...]
RASGEF1B protein networkhttps://string-db.org/network/9606.ENSP00000264400Ras-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
GPAT3 protein networkhttps://string-db.org/network/9606.ENSP00000264409Glycerol-3-phosphate acyltransferase 3; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the [...]
CUL3 protein networkhttps://string-db.org/network/9606.ENSP00000264414Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target [...]
GLRB protein networkhttps://string-db.org/network/9606.ENSP00000264428Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride chann [...]
RAPGEF2 protein networkhttps://string-db.org/network/9606.ENSP00000264431Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cA [...]
FNIP2 protein networkhttps://string-db.org/network/9606.ENSP00000264433Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client pr [...]
C2orf42 protein networkhttps://string-db.org/network/9606.ENSP00000264434Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42.
ADD2 protein networkhttps://string-db.org/network/9606.ENSP00000264436Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide [...]
MXD1 protein networkhttps://string-db.org/network/9606.ENSP00000264444Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus anta [...]
SLC30A9 protein networkhttps://string-db.org/network/9606.ENSP00000264451Zinc transporter 9; Acts as a zinc transporter involved in intracellular zinc homeostasis. Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtype [...]
SEC22C protein networkhttps://string-db.org/network/9606.ENSP00000264454Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex.
CDH10 protein networkhttps://string-db.org/network/9606.ENSP00000264463Cadherin-10; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
CSTA protein networkhttps://string-db.org/network/9606.ENSP00000264474Cystatin-A, N-terminally processed; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
FGF2 protein networkhttps://string-db.org/network/9606.ENSP00000264498Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an impor [...]
BBS7 protein networkhttps://string-db.org/network/9606.ENSP00000264499Bardet-Biedl syndrome 7 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...]
KIAA1109 protein networkhttps://string-db.org/network/9606.ENSP00000264501Transmembrane protein KIAA1109; KIAA1109.
RBBP5 protein networkhttps://string-db.org/network/9606.ENSP00000264515Retinoblastoma-binding protein 5; In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys [...]
IFT57 protein networkhttps://string-db.org/network/9606.ENSP00000264538Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway [...]
UBE2S protein networkhttps://string-db.org/network/9606.ENSP00000264552Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essentia [...]
GZMM protein networkhttps://string-db.org/network/9606.ENSP00000264553Granzyme M; Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase [...]
SHC2 protein networkhttps://string-db.org/network/9606.ENSP00000264554SHC-transforming protein 2; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activate [...]
PHRF1 protein networkhttps://string-db.org/network/9606.ENSP00000264555PHD and ring finger domains 1.
IL11 protein networkhttps://string-db.org/network/9606.ENSP00000264563Interleukin-11; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet prod [...]
AGA protein networkhttps://string-db.org/network/9606.ENSP00000264595N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
NEIL3 protein networkhttps://string-db.org/network/9606.ENSP00000264596Endonuclease 8-like 3; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displ [...]
RAB17 protein networkhttps://string-db.org/network/9606.ENSP00000264601Ras-related protein Rab-17; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
MLPH protein networkhttps://string-db.org/network/9606.ENSP00000264605Melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.
HDAC4 protein networkhttps://string-db.org/network/9606.ENSP00000264606Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
ASB1 protein networkhttps://string-db.org/network/9606.ENSP00000264607Ankyrin repeat and SOCS box protein 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 liga [...]
CP protein networkhttps://string-db.org/network/9606.ENSP00000264613Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It i [...]
WNT5A protein networkhttps://string-db.org/network/9606.ENSP00000264634Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4 [...]
THRA protein networkhttps://string-db.org/network/9606.ENSP00000264637Thyroid hormone receptor alpha; [Isoform Alpha-1]: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triio [...]
CNTNAP1 protein networkhttps://string-db.org/network/9606.ENSP00000264638Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for sal [...]
PSMD3 protein networkhttps://string-db.org/network/9606.ENSP0000026463926S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
CASC3 protein networkhttps://string-db.org/network/9606.ENSP00000264645Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on m [...]
ATP6V0A1 protein networkhttps://string-db.org/network/9606.ENSP00000264649V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific o [...]
KRT24 protein networkhttps://string-db.org/network/9606.ENSP00000264651Keratin, type I cytoskeletal 24; Keratin 24; Belongs to the intermediate filament family.
STAT3 protein networkhttps://string-db.org/network/9606.ENSP00000264657Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once a [...]
FBXL20 protein networkhttps://string-db.org/network/9606.ENSP00000264658F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
KCNH4 protein networkhttps://string-db.org/network/9606.ENSP00000264661Potassium voltage-gated channel subfamily H member 4; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties ma [...]
NNT protein networkhttps://string-db.org/network/9606.ENSP00000264663NAD(P) transhydrogenase, mitochondrial; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity [...]
FGF10 protein networkhttps://string-db.org/network/9606.ENSP00000264664Fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play [...]
FASTKD3 protein networkhttps://string-db.org/network/9606.ENSP00000264669FAST kinase domain-containing protein 3, mitochondrial; Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND [...]
NSUN2 protein networkhttps://string-db.org/network/9606.ENSP00000264670RNA cytosine C(5)-methyltransferase NSUN2; RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RN [...]
MECOM protein networkhttps://string-db.org/network/9606.ENSP00000264674Histone-lysine N-methyltransferase MECOM; [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negati [...]
UFSP2 protein networkhttps://string-db.org/network/9606.ENSP00000264689Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Do [...]
KLKB1 protein networkhttps://string-db.org/network/9606.ENSP00000264690Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases [...]
FNDC4 protein networkhttps://string-db.org/network/9606.ENSP00000264703Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expressio [...]
CAD protein networkhttps://string-db.org/network/9606.ENSP00000264705Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase); In the centr [...]
DNMT3A protein networkhttps://string-db.org/network/9606.ENSP00000264709DNA (cytosine-5)-methyltransferase 3A; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coord [...]
RAB10 protein networkhttps://string-db.org/network/9606.ENSP00000264710Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
DNAJC27 protein networkhttps://string-db.org/network/9606.ENSP00000264711DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by associati [...]
KIF3C protein networkhttps://string-db.org/network/9606.ENSP00000264712Kinesin-like protein KIF3C; Microtubule-based anterograde translocator for membranous organelles; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfami [...]
FOSL2 protein networkhttps://string-db.org/network/9606.ENSP00000264716Fos-related antigen 2; Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2- activated osteoblasts.
GCKR protein networkhttps://string-db.org/network/9606.ENSP00000264717Glucokinase regulatory protein; Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK [...]
GPN1 protein networkhttps://string-db.org/network/9606.ENSP00000264718GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA poly [...]
TP63 protein networkhttps://string-db.org/network/9606.ENSP00000264731Tumor protein 63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibit [...]
CLDN16 protein networkhttps://string-db.org/network/9606.ENSP00000264734Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorpt [...]
ITGA9 protein networkhttps://string-db.org/network/9606.ENSP00000264741Integrin alpha-9; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D- G-I-E-L in cytotactin.
ADD1 protein networkhttps://string-db.org/network/9606.ENSP00000264758Alpha-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
TMEM175 protein networkhttps://string-db.org/network/9606.ENSP00000264771Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak [...]
KCNN2 protein networkhttps://string-db.org/network/9606.ENSP00000264773Small conductance calcium-activated potassium channel protein 2; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...]
PLPP1 protein networkhttps://string-db.org/network/9606.ENSP00000264775Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate este [...]
SLC2A9 protein networkhttps://string-db.org/network/9606.ENSP00000264784Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or [...]
PRDM5 protein networkhttps://string-db.org/network/9606.ENSP00000264808PR domain zinc finger protein 5; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone [...]
MIER2 protein networkhttps://string-db.org/network/9606.ENSP00000264819Mesoderm induction early response protein 2; Transcriptional repressor.
LYL1 protein networkhttps://string-db.org/network/9606.ENSP00000264824Protein lyl-1; LYL1 basic helix-loop-helix family member.
COL5A3 protein networkhttps://string-db.org/network/9606.ENSP00000264828Collagen alpha-3(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...]
ICAM1 protein networkhttps://string-db.org/network/9606.ENSP00000264832Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement pro [...]
OLFM2 protein networkhttps://string-db.org/network/9606.ENSP00000264833Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SR [...]
KLF1 protein networkhttps://string-db.org/network/9606.ENSP00000264834Krueppel-like factor 1; Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin swit [...]
PI4K2B protein networkhttps://string-db.org/network/9606.ENSP00000264864Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be [...]
TBC1D19 protein networkhttps://string-db.org/network/9606.ENSP00000264866TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s).
PPARGC1A protein networkhttps://string-db.org/network/9606.ENSP00000264867Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PP [...]
F13A1 protein networkhttps://string-db.org/network/9606.ENSP00000264870Coagulation factor XIII A chain; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibr [...]
NUP54 protein networkhttps://string-db.org/network/9606.ENSP00000264883Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
SCARB2 protein networkhttps://string-db.org/network/9606.ENSP00000264896Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.
USO1 protein networkhttps://string-db.org/network/9606.ENSP00000264904General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent bind [...]
ANXA3 protein networkhttps://string-db.org/network/9606.ENSP00000264908Annexin A3; Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate; Belongs to the ann [...]
ARSB protein networkhttps://string-db.org/network/9606.ENSP00000264914Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithel [...]
PDE8B protein networkhttps://string-db.org/network/9606.ENSP00000264917High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May b [...]
RAD18 protein networkhttps://string-db.org/network/9606.ENSP00000264926E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on repli [...]
SLC12A7 protein networkhttps://string-db.org/network/9606.ENSP00000264930Solute carrier family 12 member 7; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribut [...]
SDHA protein networkhttps://string-db.org/network/9606.ENSP00000264932Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron t [...]
PDCD6 protein networkhttps://string-db.org/network/9606.ENSP00000264933Programmed cell death protein 6; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as a [...]
CEP72 protein networkhttps://string-db.org/network/9606.ENSP00000264935Centrosomal protein of 72 kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes [...]
SLC9A3 protein networkhttps://string-db.org/network/9606.ENSP00000264938Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
XRN1 protein networkhttps://string-db.org/network/9606.ENSP000002649515'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is [...]
GRK7 protein networkhttps://string-db.org/network/9606.ENSP00000264952Rhodopsin kinase GRK7; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). B [...]
GRPEL1 protein networkhttps://string-db.org/network/9606.ENSP00000264954GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mit [...]
EVC protein networkhttps://string-db.org/network/9606.ENSP00000264956Ellis-van Creveld syndrome protein; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development.
MGAT4A protein networkhttps://string-db.org/network/9606.ENSP00000264968Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose r [...]
ZAP70 protein networkhttps://string-db.org/network/9606.ENSP00000264972Tyrosine-protein kinase ZAP-70; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, [...]
PPP2R3A protein networkhttps://string-db.org/network/9606.ENSP00000264977Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the local [...]
CEP70 protein networkhttps://string-db.org/network/9606.ENSP00000264982Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of [...]
ACAD11 protein networkhttps://string-db.org/network/9606.ENSP00000264990Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates to beta-oxydation and energy production but could [...]
CDV3 protein networkhttps://string-db.org/network/9606.ENSP00000264993CDV3 homolog.
MRPL3 protein networkhttps://string-db.org/network/9606.ENSP00000264995Mitochondrial ribosomal protein L3.
GALNT7 protein networkhttps://string-db.org/network/9606.ENSP00000265000N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D- galactosamine residue to an already [...]
SOX30 protein networkhttps://string-db.org/network/9606.ENSP00000265007Transcription factor SOX-30; Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif [...]
BST1 protein networkhttps://string-db.org/network/9606.ENSP00000265016ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits ca [...]
FAM184B protein networkhttps://string-db.org/network/9606.ENSP00000265018Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family.
DGKG protein networkhttps://string-db.org/network/9606.ENSP00000265022Diacylglycerol kinase gamma; Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid.
MAP3K13 protein networkhttps://string-db.org/network/9606.ENSP00000265026Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activat [...]
FETUB protein networkhttps://string-db.org/network/9606.ENSP00000265029Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a p [...]
DEPDC1B protein networkhttps://string-db.org/network/9606.ENSP00000265036DEP domain containing 1B.
ERCC8 protein networkhttps://string-db.org/network/9606.ENSP00000265038DNA excision repair protein ERCC-8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide e [...]
MGLL protein networkhttps://string-db.org/network/9606.ENSP00000265052Monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2- arachidonoylglycerol, and thereby contributes to the regulation of endocannab [...]
MCM2 protein networkhttps://string-db.org/network/9606.ENSP00000265056DNA replication licensing factor MCM2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
RAB7A protein networkhttps://string-db.org/network/9606.ENSP00000265062Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and po [...]
KIAA1257 protein networkhttps://string-db.org/network/9606.ENSP00000265068Uncharacterized protein KIAA1257.
ZFR protein networkhttps://string-db.org/network/9606.ENSP00000265069Zinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity).
GOLPH3 protein networkhttps://string-db.org/network/9606.ENSP00000265070Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from [...]
CDH6 protein networkhttps://string-db.org/network/9606.ENSP00000265071Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
SUB1 protein networkhttps://string-db.org/network/9606.ENSP00000265073Activated RNA polymerase II transcriptional coactivator p15; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the ge [...]
NPR3 protein networkhttps://string-db.org/network/9606.ENSP00000265074Atrial natriuretic peptide receptor 3; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and [...]
VCAN protein networkhttps://string-db.org/network/9606.ENSP00000265077Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiati [...]
RASGRF2 protein networkhttps://string-db.org/network/9606.ENSP00000265080Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentia [...]
MSH3 protein networkhttps://string-db.org/network/9606.ENSP00000265081DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating [...]
CPEB4 protein networkhttps://string-db.org/network/9606.ENSP00000265085Cytoplasmic polyadenylation element-binding protein 4; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consens [...]
STC2 protein networkhttps://string-db.org/network/9606.ENSP00000265087Stanniocalcin-2; Has an anti-hypocalcemic action on calcium and phosphate homeostasis; Belongs to the stanniocalcin family.
FBXW11 protein networkhttps://string-db.org/network/9606.ENSP00000265094F-box/WD repeat-containing protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent prot [...]
THOC3 protein networkhttps://string-db.org/network/9606.ENSP00000265097THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcript [...]
DNAH5 protein networkhttps://string-db.org/network/9606.ENSP00000265104Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
WDR70 protein networkhttps://string-db.org/network/9606.ENSP00000265107WD repeat domain 70; Belongs to the WD repeat GAD-1 family.
SLC1A3 protein networkhttps://string-db.org/network/9606.ENSP00000265113Excitatory amino acid transporter 1; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...]
TNC protein networkhttps://string-db.org/network/9606.ENSP00000265131Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outg [...]
AMBP protein networkhttps://string-db.org/network/9606.ENSP00000265132Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-termina [...]
ARRDC3 protein networkhttps://string-db.org/network/9606.ENSP00000265138Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a [...]
SLF1 protein networkhttps://string-db.org/network/9606.ENSP00000265140SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. Th [...]
CENPE protein networkhttps://string-db.org/network/9606.ENSP00000265148Centromere-associated protein E; Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly [...]
ENPEP protein networkhttps://string-db.org/network/9606.ENSP00000265162Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
CASP6 protein networkhttps://string-db.org/network/9606.ENSP00000265164Caspase-6 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes [...]
LEF1 protein networkhttps://string-db.org/network/9606.ENSP00000265165Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differenti [...]
EGF protein networkhttps://string-db.org/network/9606.ENSP00000265171Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimul [...]
PAPSS1 protein networkhttps://string-db.org/network/9606.ENSP00000265174Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. T [...]
NME5 protein networkhttps://string-db.org/network/9606.ENSP00000265191Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes includi [...]
SIL1 protein networkhttps://string-db.org/network/9606.ENSP00000265195Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5; Be [...]
ANKRD7 protein networkhttps://string-db.org/network/9606.ENSP00000265224Ankyrin repeat domain 7.
IQCG protein networkhttps://string-db.org/network/9606.ENSP00000265239Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dis [...]
LSG1 protein networkhttps://string-db.org/network/9606.ENSP00000265245Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subun [...]
PCNP protein networkhttps://string-db.org/network/9606.ENSP00000265260PEST proteolytic signal-containing nuclear protein; May be involved in cell cycle regulation.
RBM27 protein networkhttps://string-db.org/network/9606.ENSP00000265271RNA binding motif protein 27.
GPAM protein networkhttps://string-db.org/network/9606.ENSP00000265276Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
SPDL1 protein networkhttps://string-db.org/network/9606.ENSP00000265295Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle [...]
MINDY4 protein networkhttps://string-db.org/network/9606.ENSP00000265299Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins; Belongs to the MINDY deubiquitinase family. FAM188 s [...]
TRPV5 protein networkhttps://string-db.org/network/9606.ENSP00000265310Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Req [...]
ABCB6 protein networkhttps://string-db.org/network/9606.ENSP00000265316ATP-binding cassette sub-family B member 6, mitochondrial; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis; Be [...]
PECR protein networkhttps://string-db.org/network/9606.ENSP00000265322Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4- dienoyl-CoA reductase activity.
CDKL3 protein networkhttps://string-db.org/network/9606.ENSP00000265334Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
UBE2B protein networkhttps://string-db.org/network/9606.ENSP00000265339Ubiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it p [...]
PITX1 protein networkhttps://string-db.org/network/9606.ENSP00000265340Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particu [...]
FSTL4 protein networkhttps://string-db.org/network/9606.ENSP00000265342Follistatin-related protein 4; Follistatin like 4.
AFF4 protein networkhttps://string-db.org/network/9606.ENSP00000265343AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausin [...]
MED20 protein networkhttps://string-db.org/network/9606.ENSP00000265350Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
XPO5 protein networkhttps://string-db.org/network/9606.ENSP00000265351Exportin-5; Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and [...]
SRF protein networkhttps://string-db.org/network/9606.ENSP00000265354Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initia [...]
SEMA3C protein networkhttps://string-db.org/network/9606.ENSP00000265361Semaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functi [...]
SEMA3A protein networkhttps://string-db.org/network/9606.ENSP00000265362Semaphorin-3A; Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that gu [...]
NRP1 protein networkhttps://string-db.org/network/9606.ENSP00000265371Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It [...]
CREM protein networkhttps://string-db.org/network/9606.ENSP00000265372cAMP-responsive element modulator; Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcription [...]
COL6A5 protein networkhttps://string-db.org/network/9606.ENSP00000265379Collagen alpha-5(VI) chain; Collagen VI acts as a cell-binding protein.
APBA1 protein networkhttps://string-db.org/network/9606.ENSP00000265381Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic mac [...]
PIP5K1B protein networkhttps://string-db.org/network/9606.ENSP00000265382Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contr [...]
TNPO3 protein networkhttps://string-db.org/network/9606.ENSP00000265388Transportin-3; Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS [...]
HIBADH protein networkhttps://string-db.org/network/9606.ENSP000002653953-hydroxyisobutyrate dehydrogenase, mitochondrial; 3-hydroxyisobutyrate dehydrogenase.
UGT2B10 protein networkhttps://string-db.org/network/9606.ENSP00000265403UDP-glucuronosyltransferase 2B10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyl [...]
STAP1 protein networkhttps://string-db.org/network/9606.ENSP00000265404Signal-transducing adaptor protein 1; In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity o [...]
POLB protein networkhttps://string-db.org/network/9606.ENSP00000265421DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts a [...]
CALB1 protein networkhttps://string-db.org/network/9606.ENSP00000265431Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
NBN protein networkhttps://string-db.org/network/9606.ENSP00000265433Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in d [...]
ST7 protein networkhttps://string-db.org/network/9606.ENSP00000265437Suppressor of tumorigenicity 7 protein; May act as a tumor suppressor; Belongs to the ST7 family.
TFEC protein networkhttps://string-db.org/network/9606.ENSP00000265440Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box s [...]
WNT2 protein networkhttps://string-db.org/network/9606.ENSP00000265441Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of [...]
NRXN2 protein networkhttps://string-db.org/network/9606.ENSP00000265459Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
PRDX5 protein networkhttps://string-db.org/network/9606.ENSP00000265462Peroxiredoxin-5, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell pr [...]
POLA2 protein networkhttps://string-db.org/network/9606.ENSP00000265465DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of D [...]
B3GAT3 protein networkhttps://string-db.org/network/9606.ENSP00000265471Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin su [...]
USP4 protein networkhttps://string-db.org/network/9606.ENSP00000265560Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor AD [...]
PTPN23 protein networkhttps://string-db.org/network/9606.ENSP00000265562Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endoso [...]
PRKAR2A protein networkhttps://string-db.org/network/9606.ENSP00000265563cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate mem [...]
EXOSC7 protein networkhttps://string-db.org/network/9606.ENSP00000265564Exosome complex component RRP42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
SCAP protein networkhttps://string-db.org/network/9606.ENSP00000265565Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER [...]
CLCN2 protein networkhttps://string-db.org/network/9606.ENSP00000265593Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction [...]
MCCC1 protein networkhttps://string-db.org/network/9606.ENSP00000265594Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA t [...]
LAMP3 protein networkhttps://string-db.org/network/9606.ENSP00000265598Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity.
AHI1 protein networkhttps://string-db.org/network/9606.ENSP00000265602Jouberin; Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tec [...]
ALDH8A1 protein networkhttps://string-db.org/network/9606.ENSP000002656052-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
PON3 protein networkhttps://string-db.org/network/9606.ENSP00000265627Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hyd [...]
NPTX2 protein networkhttps://string-db.org/network/9606.ENSP00000265634Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).
CPT1A protein networkhttps://string-db.org/network/9606.ENSP00000265641Carnitine O-palmitoyltransferase 1, liver isoform; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake [...]
GAL protein networkhttps://string-db.org/network/9606.ENSP00000265643Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small ne [...]
FBXO3 protein networkhttps://string-db.org/network/9606.ENSP00000265651F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leadi [...]
TCIRG1 protein networkhttps://string-db.org/network/9606.ENSP00000265686V-type proton ATPase 116 kDa subunit a isoform 3; Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation; Belongs to the V-ATPase 116 kDa subu [...]
CHKA protein networkhttps://string-db.org/network/9606.ENSP00000265689Choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidy [...]
ADAM18 protein networkhttps://string-db.org/network/9606.ENSP00000265707Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-l [...]
ADAM2 protein networkhttps://string-db.org/network/9606.ENSP00000265708Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could ha [...]
ANK1 protein networkhttps://string-db.org/network/9606.ENSP00000265709Ankyrin-1; Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cy [...]
KAT6A protein networkhttps://string-db.org/network/9606.ENSP00000265713Histone acetyltransferase KAT6A; Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyl [...]
PRKAR2B protein networkhttps://string-db.org/network/9606.ENSP00000265717cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate memb [...]
DUS4L protein networkhttps://string-db.org/network/9606.ENSP00000265720tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus4 subfamily.
ABCB4 protein networkhttps://string-db.org/network/9606.ENSP00000265723Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates s [...]
ADAM22 protein networkhttps://string-db.org/network/9606.ENSP00000265727Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adh [...]
DBF4 protein networkhttps://string-db.org/network/9606.ENSP00000265728Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S pha [...]
SRI protein networkhttps://string-db.org/network/9606.ENSP00000265729Sorcin; Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 [...]
RBM48 protein networkhttps://string-db.org/network/9606.ENSP00000265732RNA binding motif protein 48; Belongs to the RBM48 family.
CDK6 protein networkhttps://string-db.org/network/9606.ENSP00000265734Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with [...]
ANKIB1 protein networkhttps://string-db.org/network/9606.ENSP00000265742Ankyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes a [...]
ANLN protein networkhttps://string-db.org/network/9606.ENSP00000265748Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase a [...]
EIF4H protein networkhttps://string-db.org/network/9606.ENSP00000265753Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
ADAM28 protein networkhttps://string-db.org/network/9606.ENSP00000265769Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain sheddi [...]
R3HCC1 protein networkhttps://string-db.org/network/9606.ENSP00000265806R3H domain and coiled-coil containing 1.
SH2D4A protein networkhttps://string-db.org/network/9606.ENSP00000265807SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced [...]
FSCN3 protein networkhttps://string-db.org/network/9606.ENSP00000265825Fascin-3; Acts as an actin bundling protein; Belongs to the fascin family.
ZNF800 protein networkhttps://string-db.org/network/9606.ENSP00000265827Zinc finger protein 800; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ACAT1 protein networkhttps://string-db.org/network/9606.ENSP00000265838Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into [...]
ELMOD1 protein networkhttps://string-db.org/network/9606.ENSP00000265840ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family.
EXPH5 protein networkhttps://string-db.org/network/9606.ENSP00000265843Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking.
PMS2 protein networkhttps://string-db.org/network/9606.ENSP00000265849Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MS [...]
GET4 protein networkhttps://string-db.org/network/9606.ENSP00000265857Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble [...]
HNRNPH3 protein networkhttps://string-db.org/network/9606.ENSP00000265866Heterogeneous nuclear ribonucleoprotein H3; Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different i [...]
CCAR1 protein networkhttps://string-db.org/network/9606.ENSP00000265872Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals [...]
SQLE protein networkhttps://string-db.org/network/9606.ENSP00000265896Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
SNX19 protein networkhttps://string-db.org/network/9606.ENSP00000265909Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventi [...]
BRINP1 protein networkhttps://string-db.org/network/9606.ENSP00000265922BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type [...]
MAPKAP1 protein networkhttps://string-db.org/network/9606.ENSP00000265960Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast [...]
GTF2H1 protein networkhttps://string-db.org/network/9606.ENSP00000265963General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotid [...]
SERGEF protein networkhttps://string-db.org/network/9606.ENSP00000265965Secretion-regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.
HPS5 protein networkhttps://string-db.org/network/9606.ENSP00000265967Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracel [...]
KCNC1 protein networkhttps://string-db.org/network/9606.ENSP00000265969Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in r [...]
PIK3C2A protein networkhttps://string-db.org/network/9606.ENSP00000265970Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that [...]
FAM160A2 protein networkhttps://string-db.org/network/9606.ENSP00000265978FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular prote [...]
RNF141 protein networkhttps://string-db.org/network/9606.ENSP00000265981RING finger protein 141; May be involved in spermatogenesis.
HPX protein networkhttps://string-db.org/network/9606.ENSP00000265983Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
IDE protein networkhttps://string-db.org/network/9606.ENSP00000265986Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellu [...]
BTAF1 protein networkhttps://string-db.org/network/9606.ENSP00000265990TATA-binding protein-associated factor 172; Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner; Belongs to the SNF2/R [...]
CPEB3 protein networkhttps://string-db.org/network/9606.ENSP00000265997Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimul [...]
DAXX protein networkhttps://string-db.org/network/9606.ENSP00000266000Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcripti [...]
GLT8D1 protein networkhttps://string-db.org/network/9606.ENSP00000266014Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family.
RBM6 protein networkhttps://string-db.org/network/9606.ENSP00000266022RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro.
TMEM115 protein networkhttps://string-db.org/network/9606.ENSP00000266025Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi.
HYAL1 protein networkhttps://string-db.org/network/9606.ENSP00000266031Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth; Belongs to the glycosyl hydrolase 56 family.
DOCK3 protein networkhttps://string-db.org/network/9606.ENSP00000266037Dedicator of cytokinesis protein 3; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with preseni [...]
ITIH4 protein networkhttps://string-db.org/network/9606.ENSP0000026604135 kDa inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
SLIT1 protein networkhttps://string-db.org/network/9606.ENSP00000266058Slit homolog 1 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural develop [...]
SFRP5 protein networkhttps://string-db.org/network/9606.ENSP00000266066Secreted frizzled-related protein 5; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...]
GMEB2 protein networkhttps://string-db.org/network/9606.ENSP00000266068Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increas [...]
GID8 protein networkhttps://string-db.org/network/9606.ENSP00000266069Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequ [...]
DIDO1 protein networkhttps://string-db.org/network/9606.ENSP00000266070Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development.
SLC2A4RG protein networkhttps://string-db.org/network/9606.ENSP00000266077SLC2A4 regulator; Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'.
PRPF6 protein networkhttps://string-db.org/network/9606.ENSP00000266079Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone- induced tr [...]
TIMP3 protein networkhttps://string-db.org/network/9606.ENSP00000266085Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-sp [...]
SLC5A4 protein networkhttps://string-db.org/network/9606.ENSP00000266086Solute carrier family 5 member 4; Has electrogenic activity in response to glucose, and may function as a glucose sensor. Mediates influx of sodium ions into the cell but does not transport sugar [...]
FBXO7 protein networkhttps://string-db.org/network/9606.ENSP00000266087F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradati [...]
SLC5A1 protein networkhttps://string-db.org/network/9606.ENSP00000266088Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is pro [...]
EIF2B2 protein networkhttps://string-db.org/network/9606.ENSP00000266126Translation initiation factor eIF-2B subunit beta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.
TTLL1 protein networkhttps://string-db.org/network/9606.ENSP00000266254Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carbo [...]
MTFP1 protein networkhttps://string-db.org/network/9606.ENSP00000266263Mitochondrial fission process protein 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the [...]
PATZ1 protein networkhttps://string-db.org/network/9606.ENSP00000266269POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor.
TEF protein networkhttps://string-db.org/network/9606.ENSP00000266304Thyrotroph embryonic factor; Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'; Belongs to the bZIP f [...]
CACNA1C protein networkhttps://string-db.org/network/9606.ENSP00000266376Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calci [...]
B4GALNT3 protein networkhttps://string-db.org/network/9606.ENSP00000266383Beta-1,4-N-acetylgalactosaminyltransferase 3; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediam [...]
PDE6H protein networkhttps://string-db.org/network/9606.ENSP00000266395Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector mo [...]
ERP27 protein networkhttps://string-db.org/network/9606.ENSP00000266397Endoplasmic reticulum resident protein 27; Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates. Binds protein substrates via a hydrophobi [...]
ALG10 protein networkhttps://string-db.org/network/9606.ENSP00000266483Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose fr [...]
ARNTL2 protein networkhttps://string-db.org/network/9606.ENSP00000266503Aryl hydrocarbon receptor nuclear translocator-like protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, [...]
PLCZ1 protein networkhttps://string-db.org/network/9606.ENSP000002665051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...]
ZCRB1 protein networkhttps://string-db.org/network/9606.ENSP00000266529Zinc finger CCHC-type and RNA binding motif containing 1.
TMEM117 protein networkhttps://string-db.org/network/9606.ENSP00000266534Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family.
C1RL protein networkhttps://string-db.org/network/9606.ENSP00000266542Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family.
NDUFA9 protein networkhttps://string-db.org/network/9606.ENSP00000266544NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...]
CLSTN3 protein networkhttps://string-db.org/network/9606.ENSP00000266546Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, [...]
KLRG1 protein networkhttps://string-db.org/network/9606.ENSP00000266551Killer cell lectin-like receptor subfamily G member 1; Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self [...]
TAPBPL protein networkhttps://string-db.org/network/9606.ENSP00000266556Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I [...]
CD27 protein networkhttps://string-db.org/network/9606.ENSP00000266557CD27 antigen; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
RBP5 protein networkhttps://string-db.org/network/9606.ENSP00000266560Retinol-binding protein 5; Intracellular transport of retinol.
SLC38A4 protein networkhttps://string-db.org/network/9606.ENSP00000266579Sodium-coupled neutral amino acid transporter 4; Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a pre [...]
AMIGO2 protein networkhttps://string-db.org/network/9606.ENSP00000266581Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIG [...]
ANP32D protein networkhttps://string-db.org/network/9606.ENSP00000266594Acidic nuclear phosphoprotein 32 family member D; Belongs to the ANP32 family.
LLPH protein networkhttps://string-db.org/network/9606.ENSP00000266604Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission.
MARCHF9 protein networkhttps://string-db.org/network/9606.ENSP00000266643E3 ubiquitin-protein ligase MARCHF9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via mul [...]
INHBE protein networkhttps://string-db.org/network/9606.ENSP00000266646Inhibin beta E chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...]
GLIPR1 protein networkhttps://string-db.org/network/9606.ENSP00000266659Glioma pathogenesis-related protein 1; GLI pathogenesis related 1; Belongs to the CRISP family.
PHLDA1 protein networkhttps://string-db.org/network/9606.ENSP00000266671Pleckstrin homology-like domain family A member 1; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neur [...]
TMEM19 protein networkhttps://string-db.org/network/9606.ENSP00000266673Transmembrane protein 19.
LGR5 protein networkhttps://string-db.org/network/9606.ENSP00000266674Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epitheli [...]
CPSF6 protein networkhttps://string-db.org/network/9606.ENSP00000266679Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation pr [...]
SLC6A15 protein networkhttps://string-db.org/network/9606.ENSP00000266682Sodium-dependent neutral amino acid transporter B(0)AT2; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leuci [...]
TMTC3 protein networkhttps://string-db.org/network/9606.ENSP00000266712Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated pr [...]
LUM protein networkhttps://string-db.org/network/9606.ENSP00000266718Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
KERA protein networkhttps://string-db.org/network/9606.ENSP00000266719Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
TMPO protein networkhttps://string-db.org/network/9606.ENSP00000266732Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA [...]
SNRPF protein networkhttps://string-db.org/network/9606.ENSP00000266735Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, [...]
AMDHD1 protein networkhttps://string-db.org/network/9606.ENSP00000266736Probable imidazolonepropionase; Amidohydrolase domain containing 1.
ASCL1 protein networkhttps://string-db.org/network/9606.ENSP00000266744Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind [...]
SLC15A4 protein networkhttps://string-db.org/network/9606.ENSP00000266771Solute carrier family 15 member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides.
CDK2 protein networkhttps://string-db.org/network/9606.ENSP00000266970Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, N [...]
SLC39A5 protein networkhttps://string-db.org/network/9606.ENSP00000266980Zinc transporter ZIP5; May play a role in polarized cells by carrying out serosal- to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic [...]
TARBP2 protein networkhttps://string-db.org/network/9606.ENSP00000266987RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading c [...]
NPFF protein networkhttps://string-db.org/network/9606.ENSP00000267017Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pre [...]
ITGB7 protein networkhttps://string-db.org/network/9606.ENSP00000267082Integrin beta-7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (G [...]
CSAD protein networkhttps://string-db.org/network/9606.ENSP00000267085Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respect [...]
ERBB3 protein networkhttps://string-db.org/network/9606.ENSP00000267101Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand [...]
LMBR1L protein networkhttps://string-db.org/network/9606.ENSP00000267102Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein [...]
C12orf10 protein networkhttps://string-db.org/network/9606.ENSP00000267103UPF0160 protein MYG1, mitochondrial; Belongs to the UPF0160 (MYG1) family.
ESYT1 protein networkhttps://string-db.org/network/9606.ENSP00000267113Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates t [...]
ANKRD52 protein networkhttps://string-db.org/network/9606.ENSP00000267116Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...]
KRT71 protein networkhttps://string-db.org/network/9606.ENSP00000267119Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.
RB1 protein networkhttps://string-db.org/network/9606.ENSP00000267163Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcripti [...]
VPS33A protein networkhttps://string-db.org/network/9606.ENSP00000267199Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. [...]
VPS37B protein networkhttps://string-db.org/network/9606.ENSP00000267202Vacuolar protein sorting-associated protein 37B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...]
RHOF protein networkhttps://string-db.org/network/9606.ENSP00000267205Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich su [...]
PXN protein networkhttps://string-db.org/network/9606.ENSP00000267257Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion); Belongs to the paxillin family.
SRRM4 protein networkhttps://string-db.org/network/9606.ENSP00000267260Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target [...]
METTL21C protein networkhttps://string-db.org/network/9606.ENSP00000267273Protein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase. Belongs to the methyltransferase superfamily. METTL21 family.
RNF113B protein networkhttps://string-db.org/network/9606.ENSP00000267291Ring finger protein 113B.
ZIC5 protein networkhttps://string-db.org/network/9606.ENSP00000267294Zinc finger protein ZIC 5; Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity); Belongs to the GLI C2H2-type [...]
RAB20 protein networkhttps://string-db.org/network/9606.ENSP00000267328Ras-related protein Rab-20; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis [...]
ANKRD10 protein networkhttps://string-db.org/network/9606.ENSP00000267339Ankyrin repeat domain 10.
SSTR1 protein networkhttps://string-db.org/network/9606.ENSP00000267377Somatostatin receptor type 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adeny [...]
REM2 protein networkhttps://string-db.org/network/9606.ENSP00000267396GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.
CBLN3 protein networkhttps://string-db.org/network/9606.ENSP00000267406Cerebellin-3; May be involved in synaptic functions in the CNS.
TINF2 protein networkhttps://string-db.org/network/9606.ENSP00000267415TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- [...]
NOP9 protein networkhttps://string-db.org/network/9606.ENSP00000267425NOP9 nucleolar protein.
FITM1 protein networkhttps://string-db.org/network/9606.ENSP00000267426Fat storage-inducing transmembrane protein 1; Plays an important role in lipid droplet accumulation. Belongs to the FIT family.
FANCM protein networkhttps://string-db.org/network/9606.ENSP00000267430Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the [...]
L2HGDH protein networkhttps://string-db.org/network/9606.ENSP00000267436L-2-hydroxyglutarate dehydrogenase, mitochondrial; L-2-hydroxyglutarate dehydrogenase; Belongs to the L2HGDH family.
PELI2 protein networkhttps://string-db.org/network/9606.ENSP00000267460E3 ubiquitin-protein ligase pellino homolog 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathwa [...]
RTN1 protein networkhttps://string-db.org/network/9606.ENSP00000267484Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
ARMH4 protein networkhttps://string-db.org/network/9606.ENSP00000267485Armadillo-like helical domain-containing protein 4; Armadillo like helical domain containing 4.
GPR65 protein networkhttps://string-db.org/network/9606.ENSP00000267549Psychosine receptor; Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting ph [...]
JDP2 protein networkhttps://string-db.org/network/9606.ENSP00000267569Jun dimerization protein 2; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses as [...]
AK7 protein networkhttps://string-db.org/network/9606.ENSP00000267584Adenylate kinase 7; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest a [...]
FAM181A protein networkhttps://string-db.org/network/9606.ENSP00000267594Protein FAM181A; Family with sequence similarity 181 member A.
ITPK1 protein networkhttps://string-db.org/network/9606.ENSP00000267615Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1 [...]
TRIP11 protein networkhttps://string-db.org/network/9606.ENSP00000267622Thyroid receptor-interacting protein 11; Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for [...]
EMC4 protein networkhttps://string-db.org/network/9606.ENSP00000267750ER membrane protein complex subunit 4; May mediate anti-apoptotic activity.
DUOXA1 protein networkhttps://string-db.org/network/9606.ENSP00000267803Dual oxidase maturation factor 1; May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.
ZNF280D protein networkhttps://string-db.org/network/9606.ENSP00000267807Zinc finger protein 280D; May function as a transcription factor.
MFAP1 protein networkhttps://string-db.org/network/9606.ENSP00000267812Microfibrillar-associated protein 1; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the MFAP1 family.
SORD protein networkhttps://string-db.org/network/9606.ENSP00000267814Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is mostly active with D- sorbitol (D-glucitol), L-threitol, xylit [...]
LYSMD2 protein networkhttps://string-db.org/network/9606.ENSP00000267838LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2.
SLC27A2 protein networkhttps://string-db.org/network/9606.ENSP00000267842Very long-chain acyl-CoA synthetase; Acyl CoA synthetase that activates long-chain and very long- chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl- CoA. Can also activate bran [...]
FGF7 protein networkhttps://string-db.org/network/9606.ENSP00000267843Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth fa [...]
HDC protein networkhttps://string-db.org/network/9606.ENSP00000267845Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine. Belongs to the group II decarboxylase family.
MYZAP protein networkhttps://string-db.org/network/9606.ENSP00000267853Myocardial zonula adherens protein; Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to [...]
BNIP2 protein networkhttps://string-db.org/network/9606.ENSP00000267859BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins.
SRP14 protein networkhttps://string-db.org/network/9606.ENSP00000267884Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with [...]
DISP2 protein networkhttps://string-db.org/network/9606.ENSP00000267889Dispatched RND transporter family member 2.
TTBK2 protein networkhttps://string-db.org/network/9606.ENSP00000267890Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting th [...]
COMMD4 protein networkhttps://string-db.org/network/9606.ENSP00000267935COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF- kappa-B.
UBE2Q2 protein networkhttps://string-db.org/network/9606.ENSP00000267938Ubiquitin-conjugating enzyme E2 Q2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination.
BCL2A1 protein networkhttps://string-db.org/network/9606.ENSP00000267953Bcl-2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infec [...]
TSPAN3 protein networkhttps://string-db.org/network/9606.ENSP00000267970Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair; Belongs to the tetraspanin (TM4SF) family.
TLNRD1 protein networkhttps://string-db.org/network/9606.ENSP00000267984Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells.
ARRDC4 protein networkhttps://string-db.org/network/9606.ENSP00000268042Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein [...]
CYP11A1 protein networkhttps://string-db.org/network/9606.ENSP00000268053Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of mo [...]
BBS4 protein networkhttps://string-db.org/network/9606.ENSP00000268057Bardet-Biedl syndrome 4 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...]
PML protein networkhttps://string-db.org/network/9606.ENSP00000268058Protein PML; Functions via its association with PML-nuclear bodies (PML- NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, [...]
ADAMTS17 protein networkhttps://string-db.org/network/9606.ENSP00000268070ADAM metallopeptidase with thrombospondin type 1 motif 17.
SCAMP2 protein networkhttps://string-db.org/network/9606.ENSP00000268099Secretory carrier-associated membrane protein 2; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family.
RHCG protein networkhttps://string-db.org/network/9606.ENSP00000268122Ammonium transporter Rh type C; Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
RLBP1 protein networkhttps://string-db.org/network/9606.ENSP00000268125Retinaldehyde-binding protein 1; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-r [...]
ABHD2 protein networkhttps://string-db.org/network/9606.ENSP00000268129Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone recepto [...]
WDR93 protein networkhttps://string-db.org/network/9606.ENSP00000268130WD repeat domain 93.
TICRR protein networkhttps://string-db.org/network/9606.ENSP00000268138Treslin; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loadin [...]
MFGE8 protein networkhttps://string-db.org/network/9606.ENSP00000268150Lactadherin short form; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By simila [...]
ZNF710 protein networkhttps://string-db.org/network/9606.ENSP00000268154Zinc finger protein 710; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ST8SIA2 protein networkhttps://string-db.org/network/9606.ENSP00000268164Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may [...]
IQGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000268182Ras GTPase-activating-like protein IQGAP1; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activ [...]
CRTC3 protein networkhttps://string-db.org/network/9606.ENSP00000268184CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...]
EFL1 protein networkhttps://string-db.org/network/9606.ENSP00000268206Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 [...]
SEPTIN12 protein networkhttps://string-db.org/network/9606.ENSP00000268231Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating t [...]
PMM2 protein networkhttps://string-db.org/network/9606.ENSP00000268261Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.
PRSS36 protein networkhttps://string-db.org/network/9606.ENSP00000268281Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg- AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala- Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a pr [...]
UQCRC2 protein networkhttps://string-db.org/network/9606.ENSP00000268379Cytochrome b-c1 complex subunit 2, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport [...]
CDR2 protein networkhttps://string-db.org/network/9606.ENSP00000268383Cerebellar degeneration related protein 2.
IGSF6 protein networkhttps://string-db.org/network/9606.ENSP00000268389Immunoglobulin superfamily member 6.
NKD1 protein networkhttps://string-db.org/network/9606.ENSP00000268459Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.
DHX38 protein networkhttps://string-db.org/network/9606.ENSP00000268482Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome.
TXNL4B protein networkhttps://string-db.org/network/9606.ENSP00000268483Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family.
NUDT7 protein networkhttps://string-db.org/network/9606.ENSP00000268533Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresp [...]
CMTM2 protein networkhttps://string-db.org/network/9606.ENSP00000268595CKLF like MARVEL transmembrane domain containing 2.
CDH11 protein networkhttps://string-db.org/network/9606.ENSP00000268603Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
CDH13 protein networkhttps://string-db.org/network/9606.ENSP00000268613Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
ZCCHC14 protein networkhttps://string-db.org/network/9606.ENSP00000268616Zinc finger CCHC-type containing 14.
ADAD2 protein networkhttps://string-db.org/network/9606.ENSP00000268624Adenosine deaminase domain containing 2.
IRF8 protein networkhttps://string-db.org/network/9606.ENSP00000268638Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (t [...]
ZNF174 protein networkhttps://string-db.org/network/9606.ENSP00000268655Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family.
RPL3L protein networkhttps://string-db.org/network/9606.ENSP00000268661Ribosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family.
NDUFB10 protein networkhttps://string-db.org/network/9606.ENSP00000268668NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
DEF8 protein networkhttps://string-db.org/network/9606.ENSP00000268676Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.
CBFA2T3 protein networkhttps://string-db.org/network/9606.ENSP00000268679Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...]
GALNS protein networkhttps://string-db.org/network/9606.ENSP00000268695N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family.
GAS8 protein networkhttps://string-db.org/network/9606.ENSP00000268699Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dis [...]
MED9 protein networkhttps://string-db.org/network/9606.ENSP00000268711Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
NCOR1 protein networkhttps://string-db.org/network/9606.ENSP00000268712Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin [...]
COPS3 protein networkhttps://string-db.org/network/9606.ENSP00000268717COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
GID4 protein networkhttps://string-db.org/network/9606.ENSP00000268719Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitina [...]
CPNE7 protein networkhttps://string-db.org/network/9606.ENSP00000268720Copine-7; Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family.
NEK8 protein networkhttps://string-db.org/network/9606.ENSP00000268766Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through ta [...]
GFOD2 protein networkhttps://string-db.org/network/9606.ENSP00000268797Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly.
NOB1 protein networkhttps://string-db.org/network/9606.ENSP00000268802RNA-binding protein NOB1; May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity); [...]
PRPSAP2 protein networkhttps://string-db.org/network/9606.ENSP00000268835Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
UNC45B protein networkhttps://string-db.org/network/9606.ENSP00000268876Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is ne [...]
KIF2B protein networkhttps://string-db.org/network/9606.ENSP00000268919Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromos [...]
EPN3 protein networkhttps://string-db.org/network/9606.ENSP00000268933Epsin-3; Epsin 3.
SGSM2 protein networkhttps://string-db.org/network/9606.ENSP00000268989Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosome [...]
LRRC46 protein networkhttps://string-db.org/network/9606.ENSP00000269025Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46.
RHBDL3 protein networkhttps://string-db.org/network/9606.ENSP00000269051Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 [...]
SPACA3 protein networkhttps://string-db.org/network/9606.ENSP00000269053Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could [...]
ABCA10 protein networkhttps://string-db.org/network/9606.ENSP00000269081ATP-binding cassette sub-family A member 10; Probable transporter which may play a role in macrophage lipid homeostasis.
G6PC3 protein networkhttps://string-db.org/network/9606.ENSP00000269097Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex [...]
C17orf64 protein networkhttps://string-db.org/network/9606.ENSP00000269127Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64.
CDH2 protein networkhttps://string-db.org/network/9606.ENSP00000269141Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the [...]
AFG3L2 protein networkhttps://string-db.org/network/9606.ENSP00000269143AFG3-like protein 2; ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, li [...]
IMPA2 protein networkhttps://string-db.org/network/9606.ENSP00000269159Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the [...]
SLC39A6 protein networkhttps://string-db.org/network/9606.ENSP00000269187Zinc transporter ZIP6; May act as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
GALNT1 protein networkhttps://string-db.org/network/9606.ENSP00000269195Polypeptide N-acetylgalactosaminyltransferase 1 soluble form; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a ser [...]
ASXL3 protein networkhttps://string-db.org/network/9606.ENSP00000269197Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive s [...]
MEP1B protein networkhttps://string-db.org/network/9606.ENSP00000269202Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, [...]
GAREM1 protein networkhttps://string-db.org/network/9606.ENSP00000269209GRB2-associated and regulator of MAPK protein 1; [Isoform 1]: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epide [...]
ESCO1 protein networkhttps://string-db.org/network/9606.ENSP00000269214N-acetyltransferase ESCO1; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromati [...]
GATA6 protein networkhttps://string-db.org/network/9606.ENSP00000269216Transcription factor GATA-6; Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial [...]
RMC1 protein networkhttps://string-db.org/network/9606.ENSP00000269221Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and [...]
NPC1 protein networkhttps://string-db.org/network/9606.ENSP00000269228NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lyso [...]
ZMYND15 protein networkhttps://string-db.org/network/9606.ENSP00000269289Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis.
SAT2 protein networkhttps://string-db.org/network/9606.ENSP00000269298Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine.
ASGR1 protein networkhttps://string-db.org/network/9606.ENSP00000269299Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor rec [...]
TP53 protein networkhttps://string-db.org/network/9606.ENSP00000269305Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle r [...]
TTYH2 protein networkhttps://string-db.org/network/9606.ENSP00000269346Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; [...]
FN3KRP protein networkhttps://string-db.org/network/9606.ENSP00000269373Ketosamine-3-kinase; Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosph [...]
TRIM65 protein networkhttps://string-db.org/network/9606.ENSP00000269383Tripartite motif containing 65; Belongs to the TRIM/RBCC family.
CBX8 protein networkhttps://string-db.org/network/9606.ENSP00000269385Chromobox protein homolog 8; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
SECTM1 protein networkhttps://string-db.org/network/9606.ENSP00000269389Secreted and transmembrane protein 1; May be involved in thymocyte signaling.
RNF157 protein networkhttps://string-db.org/network/9606.ENSP00000269391E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neu [...]
CEP131 protein networkhttps://string-db.org/network/9606.ENSP00000269392Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating c [...]
ZNF750 protein networkhttps://string-db.org/network/9606.ENSP00000269394Zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late [...]
CBX4 protein networkhttps://string-db.org/network/9606.ENSP00000269397E3 SUMO-protein ligase CBX4; E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly r [...]
RNF165 protein networkhttps://string-db.org/network/9606.ENSP00000269439E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing [...]
DYM protein networkhttps://string-db.org/network/9606.ENSP00000269445Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family.
ELAC1 protein networkhttps://string-db.org/network/9606.ENSP00000269466Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from p [...]
SERPINB13 protein networkhttps://string-db.org/network/9606.ENSP00000269489Serpin B13; May play a role in the proliferation or differentiation of keratinocytes; Belongs to the serpin family. Ov-serpin subfamily.
ZCCHC2 protein networkhttps://string-db.org/network/9606.ENSP00000269499Zinc finger CCHC-type containing 2.
CBLN2 protein networkhttps://string-db.org/network/9606.ENSP00000269503Cerebellin-2; Acts as a synaptic organizer in specific subsets of neurons in the brain (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (By simila [...]
ERBB2 protein networkhttps://string-db.org/network/9606.ENSP00000269571Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential comp [...]
KRT10 protein networkhttps://string-db.org/network/9606.ENSP00000269576Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to [...]
PNMT protein networkhttps://string-db.org/network/9606.ENSP00000269582Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
ARL5C protein networkhttps://string-db.org/network/9606.ENSP00000269586Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP.
IGFBP4 protein networkhttps://string-db.org/network/9606.ENSP00000269593Insulin-like growth factor-binding protein 4; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...]
TXNL4A protein networkhttps://string-db.org/network/9606.ENSP00000269601Thioredoxin-like protein 4A; Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the preca [...]
AKAP8 protein networkhttps://string-db.org/network/9606.ENSP00000269701A-kinase anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mito [...]
CYP4F22 protein networkhttps://string-db.org/network/9606.ENSP00000269703Cytochrome P450 4F22; A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega- hydroxylation) of ultra-long-chain fatty acyls (C28-C36 [...]
SLC39A3 protein networkhttps://string-db.org/network/9606.ENSP00000269740Zinc transporter ZIP3; Acts as a zinc-influx transporter.
ZNF544 protein networkhttps://string-db.org/network/9606.ENSP00000269829Zinc finger protein 544; May be involved in transcriptional regulation.
ZIM3 protein networkhttps://string-db.org/network/9606.ENSP00000269834Zinc finger imprinted 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PRDM15 protein networkhttps://string-db.org/network/9606.ENSP00000269844PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell [...]
PFKL protein networkhttps://string-db.org/network/9606.ENSP00000269848ATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively r [...]
FEM1A protein networkhttps://string-db.org/network/9606.ENSP00000269856Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory [...]
CIB3 protein networkhttps://string-db.org/network/9606.ENSP00000269878Calcium and integrin binding family member 3.
CALR3 protein networkhttps://string-db.org/network/9606.ENSP00000269881Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calc [...]
SH3GL1 protein networkhttps://string-db.org/network/9606.ENSP00000269886Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity); Belongs to the endophilin family.
PGPEP1 protein networkhttps://string-db.org/network/9606.ENSP00000269919Pyroglutamyl-peptidase 1; Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
DMRTC2 protein networkhttps://string-db.org/network/9606.ENSP00000269945Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development.
CCDC97 protein networkhttps://string-db.org/network/9606.ENSP00000269967Coiled-coil domain containing 97.
ZNF45 protein networkhttps://string-db.org/network/9606.ENSP00000269973Zinc finger protein 45; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
BCKDHA protein networkhttps://string-db.org/network/9606.ENSP000002699802-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It con [...]
ZFP14 protein networkhttps://string-db.org/network/9606.ENSP00000270001Zinc finger protein 14 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SSBP4 protein networkhttps://string-db.org/network/9606.ENSP00000270061Single stranded DNA binding protein 4.
SMG9 protein networkhttps://string-db.org/network/9606.ENSP00000270066Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SM [...]
PSG9 protein networkhttps://string-db.org/network/9606.ENSP00000270077Pregnancy specific beta-1-glycoprotein 9.
HUNK protein networkhttps://string-db.org/network/9606.ENSP00000270112Hormonally up-regulated Neu-associated kinase.
LRRC56 protein networkhttps://string-db.org/network/9606.ENSP00000270115Leucine-rich repeat-containing protein 56; Required for the assembly of dynein arms. Belongs to the LRRC56 family.
IFNAR1 protein networkhttps://string-db.org/network/9606.ENSP00000270139Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interfero [...]
SOD1 protein networkhttps://string-db.org/network/9606.ENSP00000270142Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
SIK1 protein networkhttps://string-db.org/network/9606.ENSP00000270162Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and di [...]
DNMT3L protein networkhttps://string-db.org/network/9606.ENSP00000270172DNA (cytosine-5)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By simil [...]
SCYL1 protein networkhttps://string-db.org/network/9606.ENSP00000270176N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the G [...]
DMWD protein networkhttps://string-db.org/network/9606.ENSP00000270223Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing.
SAE1 protein networkhttps://string-db.org/network/9606.ENSP00000270225SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins f [...]
BCAM protein networkhttps://string-db.org/network/9606.ENSP00000270233Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling.
NTN5 protein networkhttps://string-db.org/network/9606.ENSP00000270235Netrin-5; Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube.
LMTK3 protein networkhttps://string-db.org/network/9606.ENSP00000270238Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT- [...]
GEMIN7 protein networkhttps://string-db.org/network/9606.ENSP00000270257Gem-associated protein 7; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...]
FXYD7 protein networkhttps://string-db.org/network/9606.ENSP00000270310FXYD domain containing ion transport regulator 7; Belongs to the FXYD family.
SLC6A3 protein networkhttps://string-db.org/network/9606.ENSP00000270349Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
RNPEPL1 protein networkhttps://string-db.org/network/9606.ENSP00000270357Aminopeptidase RNPEPL1; Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine. Belongs to the peptidase M1 family.
CACNG8 protein networkhttps://string-db.org/network/9606.ENSP00000270458Voltage-dependent calcium channel gamma-8 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and ga [...]
TIMM29 protein networkhttps://string-db.org/network/9606.ENSP00000270502Mitochondrial import inner membrane translocase subunit Tim29; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitoc [...]
FBN3 protein networkhttps://string-db.org/network/9606.ENSP00000270509Fibrillin-3 C-terminal peptide; [Fibrillin-3]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in el [...]
ECSIT protein networkhttps://string-db.org/network/9606.ENSP00000270517Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa [...]
TIMM44 protein networkhttps://string-db.org/network/9606.ENSP00000270538Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inn [...]
TM4SF5 protein networkhttps://string-db.org/network/9606.ENSP00000270560Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine [...]
SLC47A1 protein networkhttps://string-db.org/network/9606.ENSP00000270570Multidrug and toxin extrusion protein 1; Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanid [...]
KLHDC4 protein networkhttps://string-db.org/network/9606.ENSP00000270583Kelch domain containing 4.
PSMB6 protein networkhttps://string-db.org/network/9606.ENSP00000270586Proteasome subunit beta type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
GPR32 protein networkhttps://string-db.org/network/9606.ENSP00000270590Probable G-protein coupled receptor 32; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
ACP4 protein networkhttps://string-db.org/network/9606.ENSP00000270593Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis.
RPS11 protein networkhttps://string-db.org/network/9606.ENSP00000270625Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family.
PTH2 protein networkhttps://string-db.org/network/9606.ENSP00000270631Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces prote [...]
IGLON5 protein networkhttps://string-db.org/network/9606.ENSP00000270642IgLON family member 5.
RCN3 protein networkhttps://string-db.org/network/9606.ENSP00000270645Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactan [...]
ZNF614 protein networkhttps://string-db.org/network/9606.ENSP00000270649Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
WRAP73 protein networkhttps://string-db.org/network/9606.ENSP00000270708WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP [...]
PRDM16 protein networkhttps://string-db.org/network/9606.ENSP00000270722Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) i [...]
ARHGEF19 protein networkhttps://string-db.org/network/9606.ENSP00000270747Rho guanine nucleotide exchange factor 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase.
PGD protein networkhttps://string-db.org/network/9606.ENSP000002707766-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
SH3BGRL3 protein networkhttps://string-db.org/network/9606.ENSP00000270792SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity.
IL22RA1 protein networkhttps://string-db.org/network/9606.ENSP00000270800Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. [...]
EVA1B protein networkhttps://string-db.org/network/9606.ENSP00000270824Eva-1 homolog B; Belongs to the EVA1 family.
PLK4 protein networkhttps://string-db.org/network/9606.ENSP00000270861Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental cen [...]
FCN3 protein networkhttps://string-db.org/network/9606.ENSP00000270879Ficolin-3; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/ol [...]
TINAGL1 protein networkhttps://string-db.org/network/9606.ENSP00000271064Tubulointerstitial nephritis antigen-like; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non cat [...]
MOB3C protein networkhttps://string-db.org/network/9606.ENSP00000271139MOB kinase activator 3C; May regulate the activity of kinases; Belongs to the MOB1/phocein family.
SLC44A3 protein networkhttps://string-db.org/network/9606.ENSP00000271227Choline transporter-like protein 3; Solute carrier family 44 member 3.
FNBP1L protein networkhttps://string-db.org/network/9606.ENSP00000271234Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bis [...]
CTTNBP2NL protein networkhttps://string-db.org/network/9606.ENSP00000271277CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like.
PSMA5 protein networkhttps://string-db.org/network/9606.ENSP00000271308Proteasome subunit alpha type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
PROK1 protein networkhttps://string-db.org/network/9606.ENSP00000271331Prokineticin-1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cell [...]
CELSR2 protein networkhttps://string-db.org/network/9606.ENSP00000271332Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. [...]
MPC2 protein networkhttps://string-db.org/network/9606.ENSP00000271373Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria.
SFT2D2 protein networkhttps://string-db.org/network/9606.ENSP00000271375Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.
ILDR2 protein networkhttps://string-db.org/network/9606.ENSP00000271417Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways. Belongs to the immunoglobulin superfamily. LISCH7 family.
FCGR2A protein networkhttps://string-db.org/network/9606.ENSP00000271450Low affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathog [...]
NUF2 protein networkhttps://string-db.org/network/9606.ENSP00000271452Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kin [...]
UAP1 protein networkhttps://string-db.org/network/9606.ENSP00000271469UDP-N-acetylgalactosamine pyrophosphorylase; Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, [...]
PRCC protein networkhttps://string-db.org/network/9606.ENSP00000271526Proline-rich protein PRCC; May regulate cell cycle progression through interaction with MAD2L2.
FCRL4 protein networkhttps://string-db.org/network/9606.ENSP00000271532Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
MEF2D protein networkhttps://string-db.org/network/9606.ENSP00000271555Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-indu [...]
HMCN1 protein networkhttps://string-db.org/network/9606.ENSP00000271588Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a [...]
PRUNE1 protein networkhttps://string-db.org/network/9606.ENSP00000271620Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a n [...]
SF3B4 protein networkhttps://string-db.org/network/9606.ENSP00000271628Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...]
CGN protein networkhttps://string-db.org/network/9606.ENSP00000271636Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family.
S100A11 protein networkhttps://string-db.org/network/9606.ENSP00000271638Protein S100-A11, N-terminally processed; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family.
SETDB1 protein networkhttps://string-db.org/network/9606.ENSP00000271640Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic tran [...]
CTSK protein networkhttps://string-db.org/network/9606.ENSP00000271651Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at [...]
CERS2 protein networkhttps://string-db.org/network/9606.ENSP00000271688Ceramide synthase 2; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) chain as acyl donor.
POGZ protein networkhttps://string-db.org/network/9606.ENSP00000271715Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its assoc [...]
GOLPH3L protein networkhttps://string-db.org/network/9606.ENSP00000271732Golgi phosphoprotein 3-like; Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and antero [...]
KCNH1 protein networkhttps://string-db.org/network/9606.ENSP00000271751Potassium voltage-gated channel subfamily H member 1; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Me [...]
EIF2D protein networkhttps://string-db.org/network/9606.ENSP00000271764Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tR [...]
CRNN protein networkhttps://string-db.org/network/9606.ENSP00000271835Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response v [...]
JTB protein networkhttps://string-db.org/network/9606.ENSP00000271843Protein JTB; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that ac [...]
SLC27A3 protein networkhttps://string-db.org/network/9606.ENSP00000271857Solute carrier family 27 member 3; Has acyl-CoA ligase activity for long-chain and very-long- chain fatty acids. Does not exhibit fatty acid transport activity (By similarity).
CREB3L4 protein networkhttps://string-db.org/network/9606.ENSP00000271889Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not [...]
CAPN9 protein networkhttps://string-db.org/network/9606.ENSP00000271971Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.
ACP1 protein networkhttps://string-db.org/network/9606.ENSP00000272067Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess ph [...]
SDE2 protein networkhttps://string-db.org/network/9606.ENSP00000272091Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP- box. The interaction with PCNA prevents mono [...]
CNIH3 protein networkhttps://string-db.org/network/9606.ENSP00000272133Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modula [...]
LEFTY1 protein networkhttps://string-db.org/network/9606.ENSP00000272134Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
C1orf35 protein networkhttps://string-db.org/network/9606.ENSP00000272139Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35.
WNT9A protein networkhttps://string-db.org/network/9606.ENSP00000272164Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal timing of IHH expres [...]
REN protein networkhttps://string-db.org/network/9606.ENSP00000272190Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an eleva [...]
PLEKHA6 protein networkhttps://string-db.org/network/9606.ENSP00000272203Pleckstrin homology domain containing A6.
ARL8A protein networkhttps://string-db.org/network/9606.ENSP00000272217ADP-ribosylation factor-like protein 8A; Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicl [...]
OSR1 protein networkhttps://string-db.org/network/9606.ENSP00000272223Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development.
GDF7 protein networkhttps://string-db.org/network/9606.ENSP00000272224Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex.
RHOB protein networkhttps://string-db.org/network/9606.ENSP00000272233Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling [...]
ATP6V1C2 protein networkhttps://string-db.org/network/9606.ENSP00000272238V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a sp [...]
GALM protein networkhttps://string-db.org/network/9606.ENSP00000272252Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).
ABCG8 protein networkhttps://string-db.org/network/9606.ENSP00000272286ATP-binding cassette sub-family G member 8; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role [...]
RPS27A protein networkhttps://string-db.org/network/9606.ENSP00000272317Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an is [...]
WDPCP protein networkhttps://string-db.org/network/9606.ENSP00000272321WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both cilio [...]
VPS54 protein networkhttps://string-db.org/network/9606.ENSP00000272322Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The [...]
REG3G protein networkhttps://string-db.org/network/9606.ENSP00000272324Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exp [...]
ETAA1 protein networkhttps://string-db.org/network/9606.ENSP00000272342Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replicat [...]
CLEC4F protein networkhttps://string-db.org/network/9606.ENSP00000272367C-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity).
MEIS1 protein networkhttps://string-db.org/network/9606.ENSP00000272369Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage dev [...]
OTOF protein networkhttps://string-db.org/network/9606.ENSP00000272371Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a [...]
TRIM43 protein networkhttps://string-db.org/network/9606.ENSP00000272395Tripartite motif containing 43.
MRPS5 protein networkhttps://string-db.org/network/9606.ENSP00000272418Mitochondrial ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family.
NAT8 protein networkhttps://string-db.org/network/9606.ENSP00000272425N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of r [...]
RTKN protein networkhttps://string-db.org/network/9606.ENSP00000272430Rhotekin; Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin str [...]
SFXN5 protein networkhttps://string-db.org/network/9606.ENSP00000272433Sideroflexin-5; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Transports citrate (By simil [...]
TEX261 protein networkhttps://string-db.org/network/9606.ENSP00000272438Protein TEX261; Testis expressed 261.
DUSP11 protein networkhttps://string-db.org/network/9606.ENSP00000272444RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase ac [...]
SULT1C4 protein networkhttps://string-db.org/network/9606.ENSP00000272452Sulfotransferase 1C4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neu [...]
MALL protein networkhttps://string-db.org/network/9606.ENSP00000272462MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family.
RALB protein networkhttps://string-db.org/network/9606.ENSP00000272519Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane [...]
C1QL2 protein networkhttps://string-db.org/network/9606.ENSP00000272520Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).
SLC20A1 protein networkhttps://string-db.org/network/9606.ENSP00000272542Sodium-dependent phosphate transporter 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for no [...]
CNGA3 protein networkhttps://string-db.org/network/9606.ENSP00000272602Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP w [...]
UBXN4 protein networkhttps://string-db.org/network/9606.ENSP00000272638UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
NXPH2 protein networkhttps://string-db.org/network/9606.ENSP00000272641Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.
POLR2D protein networkhttps://string-db.org/network/9606.ENSP00000272645DNA-directed RNA polymerase II subunit RPB4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
AMMECR1L protein networkhttps://string-db.org/network/9606.ENSP00000272647AMMECR1-like protein; AMMECR1 like.
SCRN3 protein networkhttps://string-db.org/network/9606.ENSP00000272732Secernin-3; Secernin 3.
TMEFF2 protein networkhttps://string-db.org/network/9606.ENSP00000272771Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Belongs t [...]
METTL21A protein networkhttps://string-db.org/network/9606.ENSP00000272839Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo t [...]
PTH2R protein networkhttps://string-db.org/network/9606.ENSP00000272847Parathyroid hormone 2 receptor; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsi [...]
CPO protein networkhttps://string-db.org/network/9606.ENSP00000272852Carboxypeptidase O; Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for [...]
ABCA12 protein networkhttps://string-db.org/network/9606.ENSP00000272895ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family.
SUMF1 protein networkhttps://string-db.org/network/9606.ENSP00000272902Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3- oxoalanine mo [...]
ACKR3 protein networkhttps://string-db.org/network/9606.ENSP00000272928Atypical chemokine receptor 3; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...]
HES6 protein networkhttps://string-db.org/network/9606.ENSP00000272937Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-me [...]
RAB5A protein networkhttps://string-db.org/network/9606.ENSP00000273047Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular res [...]
CTDSP1 protein networkhttps://string-db.org/network/9606.ENSP00000273062Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain [...]
SLC4A3 protein networkhttps://string-db.org/network/9606.ENSP00000273063Anion exchange protein 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transpo [...]
MARCHF4 protein networkhttps://string-db.org/network/9606.ENSP00000273067E3 ubiquitin-protein ligase MARCHF4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesic [...]
PNKD protein networkhttps://string-db.org/network/9606.ENSP00000273077Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway; Belongs to the metallo-bet [...]
DYNC1LI1 protein networkhttps://string-db.org/network/9606.ENSP00000273130Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to [...]
CSRNP1 protein networkhttps://string-db.org/network/9606.ENSP00000273153Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor- suppressor function. May play a [...]
SLC22A14 protein networkhttps://string-db.org/network/9606.ENSP00000273173Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
CTDSPL protein networkhttps://string-db.org/network/9606.ENSP00000273179CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially cataly [...]
STAC protein networkhttps://string-db.org/network/9606.ENSP00000273183SH3 and cysteine-rich domain-containing protein; Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor [...]
ARL6IP5 protein networkhttps://string-db.org/network/9606.ENSP00000273258PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in [...]
LRIG1 protein networkhttps://string-db.org/network/9606.ENSP00000273261Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of r [...]
ITIH1 protein networkhttps://string-db.org/network/9606.ENSP00000273283Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...]
LRTM1 protein networkhttps://string-db.org/network/9606.ENSP00000273286Leucine rich repeats and transmembrane domains 1.
CNPY2 protein networkhttps://string-db.org/network/9606.ENSP00000273308Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal [...]
LIMD1 protein networkhttps://string-db.org/network/9606.ENSP00000273317LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate deter [...]
ZKSCAN7 protein networkhttps://string-db.org/network/9606.ENSP00000273320Zinc finger protein with KRAB and SCAN domains 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NXPE3 protein networkhttps://string-db.org/network/9606.ENSP00000273347NXPE family member 3; Neurexophilin and PC-esterase domain family member 3.
ADGRG7 protein networkhttps://string-db.org/network/9606.ENSP00000273352Adhesion G-protein coupled receptor G7; Orphan receptor.
MYH15 protein networkhttps://string-db.org/network/9606.ENSP00000273353Myosin-15; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
ABHD10 protein networkhttps://string-db.org/network/9606.ENSP00000273359Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl- glucuronide, a metabolite of the immunosuppressant drug mycophenolate. Belon [...]
PLA1A protein networkhttps://string-db.org/network/9606.ENSP00000273371Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposome [...]
RABL3 protein networkhttps://string-db.org/network/9606.ENSP00000273375Rab-like protein 3; RAB, member of RAS oncogene family like 3; Belongs to the small GTPase superfamily. Rab family.
MAATS1 protein networkhttps://string-db.org/network/9606.ENSP00000273390Cilia- and flagella-associated protein 91; May play a role in spermatogenesis. May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).
BOC protein networkhttps://string-db.org/network/9606.ENSP00000273395Brother of CDO; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.
ATP6V1A protein networkhttps://string-db.org/network/9606.ENSP00000273398V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular comp [...]
ALDH1L1 protein networkhttps://string-db.org/network/9606.ENSP00000273450Cytosolic 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L1; In the N-terminal section; belongs to the GART family.
RNF7 protein networkhttps://string-db.org/network/9606.ENSP00000273480RING-box protein 2; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [...]
ISY1 protein networkhttps://string-db.org/network/9606.ENSP00000273541ISY1 splicing factor homolog.
FTH1 protein networkhttps://string-db.org/network/9606.ENSP00000273550Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrou [...]
AMT protein networkhttps://string-db.org/network/9606.ENSP00000273588Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
TCTA protein networkhttps://string-db.org/network/9606.ENSP00000273590T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family.
ABHD14A protein networkhttps://string-db.org/network/9606.ENSP00000273596Protein ABHD14A; Possible role in granule neuron development; Belongs to the AB hydrolase superfamily. ABHD14 family.
NICN1 protein networkhttps://string-db.org/network/9606.ENSP00000273598Nicolin-1; Nicolin 1.
UCN2 protein networkhttps://string-db.org/network/9606.ENSP00000273610Urocortin-2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress; Belongs to the sauvag [...]
STXBP5L protein networkhttps://string-db.org/network/9606.ENSP00000273666Syntaxin-binding protein 5-like; Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating ST [...]
EAF2 protein networkhttps://string-db.org/network/9606.ENSP00000273668ELL-associated factor 2; Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Pot [...]
TM4SF19 protein networkhttps://string-db.org/network/9606.ENSP00000273695Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family.
AHSG protein networkhttps://string-db.org/network/9606.ENSP00000273784Alpha-2-HS-glycoprotein chain A; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Belongs to the fetuin fam [...]
DGKQ protein networkhttps://string-db.org/network/9606.ENSP00000273814Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two sig [...]
CENPC protein networkhttps://string-db.org/network/9606.ENSP00000273853Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
CORIN protein networkhttps://string-db.org/network/9606.ENSP00000273857Atrial natriuretic peptide-converting enzyme, activated protease fragment; Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic [...]
ATP10D protein networkhttps://string-db.org/network/9606.ENSP00000273859Probable phospholipid-transporting ATPase VD; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...]
SLC10A4 protein networkhttps://string-db.org/network/9606.ENSP00000273861Sodium/bile acid cotransporter 4; Transporter for bile acids; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
SLC10A6 protein networkhttps://string-db.org/network/9606.ENSP00000273905Solute carrier family 10 member 6; Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner; Belongs to the [...]
ENOPH1 protein networkhttps://string-db.org/network/9606.ENSP00000273920Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1 [...]
CABS1 protein networkhttps://string-db.org/network/9606.ENSP00000273936Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1.
TRMT10A protein networkhttps://string-db.org/network/9606.ENSP00000273962tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably n [...]
KLHL8 protein networkhttps://string-db.org/network/9606.ENSP00000273963Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation [...]
PYURF protein networkhttps://string-db.org/network/9606.ENSP00000273968Protein preY, mitochondrial; PIGY upstream reading frame; Belongs to the PREY family.
CISD2 protein networkhttps://string-db.org/network/9606.ENSP00000273986CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interacti [...]
AP1AR protein networkhttps://string-db.org/network/9606.ENSP00000274000AP-1 complex-associated regulatory protein; Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of [...]
SPATA5 protein networkhttps://string-db.org/network/9606.ENSP00000274008ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. May be involved in morphol [...]
FABP2 protein networkhttps://string-db.org/network/9606.ENSP00000274024Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglycer [...]
SETD7 protein networkhttps://string-db.org/network/9606.ENSP00000274031Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcr [...]
NAF1 protein networkhttps://string-db.org/network/9606.ENSP00000274054H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs c [...]
SFRP2 protein networkhttps://string-db.org/network/9606.ENSP00000274063Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...]
GLRA3 protein networkhttps://string-db.org/network/9606.ENSP00000274093Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit compos [...]
NDUFS6 protein networkhttps://string-db.org/network/9606.ENSP00000274137NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be [...]
MARCHF6 protein networkhttps://string-db.org/network/9606.ENSP00000274140E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination [...]
ADAMTS16 protein networkhttps://string-db.org/network/9606.ENSP00000274181ADAM metallopeptidase with thrombospondin type 1 motif 16.
SRD5A1 protein networkhttps://string-db.org/network/9606.ENSP000002741923-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a cent [...]
OTULINL protein networkhttps://string-db.org/network/9606.ENSP00000274217Inactive ubiquitin thioesterase OTULINL; Lacks deubiquitinase activity; Belongs to the peptidase C65 family. Otulin subfamily.
RPL37 protein networkhttps://string-db.org/network/9606.ENSP0000027424260S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.
SKP2 protein networkhttps://string-db.org/network/9606.ENSP00000274255S-phase kinase-associated protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent protea [...]
OSMR protein networkhttps://string-db.org/network/9606.ENSP00000274276Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signa [...]
UGT3A1 protein networkhttps://string-db.org/network/9606.ENSP00000274278UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...]
PLK2 protein networkhttps://string-db.org/network/9606.ENSP00000274289Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by b [...]
GZMA protein networkhttps://string-db.org/network/9606.ENSP00000274306Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered i [...]
PELO protein networkhttps://string-db.org/network/9606.ENSP00000274311Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonuc [...]
HAPLN1 protein networkhttps://string-db.org/network/9606.ENSP00000274341Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
BHMT protein networkhttps://string-db.org/network/9606.ENSP00000274353Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reactio [...]
ANKRD31 protein networkhttps://string-db.org/network/9606.ENSP00000274361Ankyrin repeat domain-containing protein 31; Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinos [...]
IQGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000274364Ras GTPase-activating-like protein IQGAP2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
CRHBP protein networkhttps://string-db.org/network/9606.ENSP00000274368Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy; Belongs to the CRF-binding protein family.
RASA1 protein networkhttps://string-db.org/network/9606.ENSP00000274376Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the pr [...]
LIX1 protein networkhttps://string-db.org/network/9606.ENSP00000274382Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family.
GTF2H2 protein networkhttps://string-db.org/network/9606.ENSP00000274400General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotid [...]
SPATA9 protein networkhttps://string-db.org/network/9606.ENSP00000274432Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility.
FEM1C protein networkhttps://string-db.org/network/9606.ENSP00000274457Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family.
COMMD10 protein networkhttps://string-db.org/network/9606.ENSP00000274458COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B.
ADAMTS19 protein networkhttps://string-db.org/network/9606.ENSP00000274487ADAM metallopeptidase with thrombospondin type 1 motif 19.
YIPF5 protein networkhttps://string-db.org/network/9606.ENSP00000274496Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi.
ARHGAP26 protein networkhttps://string-db.org/network/9606.ENSP00000274498Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42.
LECT2 protein networkhttps://string-db.org/network/9606.ENSP00000274507Leukocyte cell-derived chemotaxin-2; Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Does not show metalloendopeptidase activity. Belongs to the LEC [...]
IL9 protein networkhttps://string-db.org/network/9606.ENSP00000274520Interleukin-9; Supports IL-2 independent and IL-4 independent growth of helper T-cells; Belongs to the IL-7/IL-9 family.
TIMD4 protein networkhttps://string-db.org/network/9606.ENSP00000274532T-cell immunoglobulin and mucin domain-containing protein 4; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotox [...]
GABRA6 protein networkhttps://string-db.org/network/9606.ENSP00000274545Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
GABRB2 protein networkhttps://string-db.org/network/9606.ENSP00000274547Gamma-aminobutyric acid receptor subunit beta-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. [...]
SPINK7 protein networkhttps://string-db.org/network/9606.ENSP00000274565Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor.
PCYOX1L protein networkhttps://string-db.org/network/9606.ENSP00000274569Prenylcysteine oxidase-like; Probable oxidoreductase.
N4BP3 protein networkhttps://string-db.org/network/9606.ENSP00000274605NEDD4-binding protein 3; Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior [...]
NHP2 protein networkhttps://string-db.org/network/9606.ENSP00000274606H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...]
FGF18 protein networkhttps://string-db.org/network/9606.ENSP00000274625Fibroblast growth factor 18; Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimu [...]
KCNMB1 protein networkhttps://string-db.org/network/9606.ENSP00000274629Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...]
MYLK4 protein networkhttps://string-db.org/network/9606.ENSP00000274643Myosin light chain kinase family member 4.
FAM217A protein networkhttps://string-db.org/network/9606.ENSP00000274673Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family.
CDKAL1 protein networkhttps://string-db.org/network/9606.ENSP00000274695Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladen [...]
PSD2 protein networkhttps://string-db.org/network/9606.ENSP00000274710Pleckstrin and Sec7 domain containing 2.
LRRTM2 protein networkhttps://string-db.org/network/9606.ENSP00000274711Leucine-rich repeat transmembrane neuronal protein 2; Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA rece [...]
ZMAT2 protein networkhttps://string-db.org/network/9606.ENSP00000274712Zinc finger matrin-type protein 2; Involved in pre-mRNA splicing as a component of the spliceosome.
GFRA3 protein networkhttps://string-db.org/network/9606.ENSP00000274721GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyr [...]
H2BC1 protein networkhttps://string-db.org/network/9606.ENSP00000274764Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical h [...]
KAAG1 protein networkhttps://string-db.org/network/9606.ENSP00000274766Kidney associated antigen 1.
TRIM7 protein networkhttps://string-db.org/network/9606.ENSP00000274773E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling [...]
HIGD2A protein networkhttps://string-db.org/network/9606.ENSP00000274787HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the [...]
PLA2G7 protein networkhttps://string-db.org/network/9606.ENSP00000274793Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specific [...]
RNF44 protein networkhttps://string-db.org/network/9606.ENSP00000274811Ring finger protein 44.
MMUT protein networkhttps://string-db.org/network/9606.ENSP00000274813Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has diffe [...]
ABT1 protein networkhttps://string-db.org/network/9606.ENSP00000274849Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II g [...]
SCUBE3 protein networkhttps://string-db.org/network/9606.ENSP00000274938Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TG [...]
FGD2 protein networkhttps://string-db.org/network/9606.ENSP00000274963FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not [...]
ANO7 protein networkhttps://string-db.org/network/9606.ENSP00000274979Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated c [...]
NFKBIE protein networkhttps://string-db.org/network/9606.ENSP00000275015NF-kappa-B inhibitor epsilon; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
CYP39A1 protein networkhttps://string-db.org/network/9606.ENSP0000027501624-hydroxycholesterol 7-alpha-hydroxylase; A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)- hydroxyc [...]
PHIP protein networkhttps://string-db.org/network/9606.ENSP00000275034PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an an [...]
MMS22L protein networkhttps://string-db.org/network/9606.ENSP00000275053Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is requ [...]
PM20D2 protein networkhttps://string-db.org/network/9606.ENSP00000275072Peptidase M20 domain containing 2.
CLVS2 protein networkhttps://string-db.org/network/9606.ENSP00000275162Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).
TAAR6 protein networkhttps://string-db.org/network/9606.ENSP00000275198Trace amine-associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...]
TAAR8 protein networkhttps://string-db.org/network/9606.ENSP00000275200Trace amine-associated receptor 8; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...]
TAAR1 protein networkhttps://string-db.org/network/9606.ENSP00000275216Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Un [...]
SLC18B1 protein networkhttps://string-db.org/network/9606.ENSP00000275227MFS-type transporter SLC18B1; Solute carrier family 18 member B1.
SLC2A12 protein networkhttps://string-db.org/network/9606.ENSP00000275230Solute carrier family 2, facilitated glucose transporter member 12; Insulin-independent facilitative glucose transporter. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1 [...]
SHPRH protein networkhttps://string-db.org/network/9606.ENSP00000275233E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of P [...]
SLC22A3 protein networkhttps://string-db.org/network/9606.ENSP00000275300Solute carrier family 22 member 3; Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmit [...]
VWDE protein networkhttps://string-db.org/network/9606.ENSP00000275358Von Willebrand factor D and EGF domains.
GNA12 protein networkhttps://string-db.org/network/9606.ENSP00000275364Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activat [...]
GGCT protein networkhttps://string-db.org/network/9606.ENSP00000275428Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c [...]
FERD3L protein networkhttps://string-db.org/network/9606.ENSP00000275461Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation [...]
EGFR protein networkhttps://string-db.org/network/9606.ENSP00000275493Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular resp [...]
CDCA5 protein networkhttps://string-db.org/network/9606.ENSP00000275517Sororin; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chr [...]
IGFBP1 protein networkhttps://string-db.org/network/9606.ENSP00000275525Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...]
SSC4D protein networkhttps://string-db.org/network/9606.ENSP00000275560Scavenger receptor cysteine-rich domain-containing group B protein; Scavenger receptor cysteine rich family member with 4 domains.
CCT6A protein networkhttps://string-db.org/network/9606.ENSP00000275603T-complex protein 1 subunit zeta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex [...]
SLC12A9 protein networkhttps://string-db.org/network/9606.ENSP00000275730Solute carrier family 12 member 9; May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function [...]
GIGYF1 protein networkhttps://string-db.org/network/9606.ENSP00000275732GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phos [...]
STRA8 protein networkhttps://string-db.org/network/9606.ENSP00000275764Stimulated by retinoic acid gene 8 protein homolog; Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA [...]
ZC3HAV1L protein networkhttps://string-db.org/network/9606.ENSP00000275766Zinc finger CCCH-type containing, antiviral 1 like.
TMEM140 protein networkhttps://string-db.org/network/9606.ENSP00000275767Transmembrane protein 140.
EPHA1 protein networkhttps://string-db.org/network/9606.ENSP00000275815Ephrin type-A receptor 1; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signali [...]
NOM1 protein networkhttps://string-db.org/network/9606.ENSP00000275820Nucleolar MIF4G domain-containing protein 1; Plays a role in targeting PPP1CA to the nucleolus.
TMEM47 protein networkhttps://string-db.org/network/9606.ENSP00000275954Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polym [...]
CDK16 protein networkhttps://string-db.org/network/9606.ENSP00000276052Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regula [...]
CHST7 protein networkhttps://string-db.org/network/9606.ENSP00000276055Carbohydrate sulfotransferase 7; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...]
NDUFB11 protein networkhttps://string-db.org/network/9606.ENSP00000276062NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...]
NONO protein networkhttps://string-db.org/network/9606.ENSP00000276079Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds [...]
CPXCR1 protein networkhttps://string-db.org/network/9606.ENSP00000276127CPX chromosome region candidate 1.
RIPPLY1 protein networkhttps://string-db.org/network/9606.ENSP00000276173Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, a [...]
FRMPD3 protein networkhttps://string-db.org/network/9606.ENSP00000276185FERM and PDZ domain containing 3.
HTR2C protein networkhttps://string-db.org/network/9606.ENSP000002761985-hydroxytryptamine receptor 2C; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkalo [...]
UPF3B protein networkhttps://string-db.org/network/9606.ENSP00000276201Regulator of nonsense transcripts 3B; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving a [...]
DOCK11 protein networkhttps://string-db.org/network/9606.ENSP00000276202Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is ass [...]
ARHGAP36 protein networkhttps://string-db.org/network/9606.ENSP00000276211Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
GPR119 protein networkhttps://string-db.org/network/9606.ENSP00000276218Glucose-dependent insulinotropic receptor; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulin [...]
CT55 protein networkhttps://string-db.org/network/9606.ENSP00000276241Cancer/testis antigen 55.
MFHAS1 protein networkhttps://string-db.org/network/9606.ENSP00000276282Malignant fibrous histiocytoma-amplified sequence 1; Probable GTP-binding protein. Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like rec [...]
DLC1 protein networkhttps://string-db.org/network/9606.ENSP00000276297Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological chan [...]
ATP6V1B2 protein networkhttps://string-db.org/network/9606.ENSP00000276390V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartment [...]
CHRNA6 protein networkhttps://string-db.org/network/9606.ENSP00000276410Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
GNRH1 protein networkhttps://string-db.org/network/9606.ENSP00000276414GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
BIN3 protein networkhttps://string-db.org/network/9606.ENSP00000276416Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin.
DOK2 protein networkhttps://string-db.org/network/9606.ENSP00000276420Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate [...]
TNFRSF10B protein networkhttps://string-db.org/network/9606.ENSP00000276431Tumor necrosis factor receptor superfamily member 10B; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death [...]
DOCK5 protein networkhttps://string-db.org/network/9606.ENSP00000276440Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with [...]
STAR protein networkhttps://string-db.org/network/9606.ENSP00000276449Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholest [...]
ST18 protein networkhttps://string-db.org/network/9606.ENSP00000276480Suppression of tumorigenicity 18 protein; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleot [...]
GINS4 protein networkhttps://string-db.org/network/9606.ENSP00000276533DNA replication complex GINS protein SLD5, N-terminally processed; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 i [...]
ARMC1 protein networkhttps://string-db.org/network/9606.ENSP00000276569Armadillo repeat containing 1.
DNAJC5B protein networkhttps://string-db.org/network/9606.ENSP00000276570DnaJ heat shock protein family member C5 beta.
CRH protein networkhttps://string-db.org/network/9606.ENSP00000276571Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By [...]
MRPS28 protein networkhttps://string-db.org/network/9606.ENSP00000276585Mitochondrial ribosomal protein S28; Belongs to the bacterial ribosomal protein bS1 family.
LACTB2 protein networkhttps://string-db.org/network/9606.ENSP00000276590Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no ac [...]
PRDM14 protein networkhttps://string-db.org/network/9606.ENSP00000276594PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisiti [...]
TERF1 protein networkhttps://string-db.org/network/9606.ENSP00000276603Telomeric repeat-binding factor 1; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component o [...]
PSKH2 protein networkhttps://string-db.org/network/9606.ENSP00000276616Protein serine kinase H2.
DPYS protein networkhttps://string-db.org/network/9606.ENSP00000276651Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrou [...]
LRP12 protein networkhttps://string-db.org/network/9606.ENSP00000276654Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppres [...]
RSPO2 protein networkhttps://string-db.org/network/9606.ENSP00000276659R-spondin-2; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...]
NDUFB9 protein networkhttps://string-db.org/network/9606.ENSP00000276689NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved [...]
TATDN1 protein networkhttps://string-db.org/network/9606.ENSP00000276692Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
C8orf76 protein networkhttps://string-db.org/network/9606.ENSP00000276704Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76.
GSDMC protein networkhttps://string-db.org/network/9606.ENSP00000276708Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Proba [...]
ZNF16 protein networkhttps://string-db.org/network/9606.ENSP00000276816Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and [...]
UHRF2 protein networkhttps://string-db.org/network/9606.ENSP00000276893E3 ubiquitin-protein ligase UHRF2; E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a ti [...]
PLIN2 protein networkhttps://string-db.org/network/9606.ENSP00000276914Perilipin-2; May be involved in development and maintenance of adipose tissue; Belongs to the perilipin family.
CDKN2B protein networkhttps://string-db.org/network/9606.ENSP00000276925Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kin [...]
IFNA1 protein networkhttps://string-db.org/network/9606.ENSP00000276927Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belong [...]
IFNK protein networkhttps://string-db.org/network/9606.ENSP00000276943Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interfer [...]
SIGMAR1 protein networkhttps://string-db.org/network/9606.ENSP00000277010Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the bio [...]
NTRK2 protein networkhttps://string-db.org/network/9606.ENSP00000277120BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, [...]
FAM120A protein networkhttps://string-db.org/network/9606.ENSP00000277165Constitutive coactivator of PPAR-gamma-like protein 1; May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. A [...]
OR13C4 protein networkhttps://string-db.org/network/9606.ENSP00000277216Olfactory receptor 13C4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF462 protein networkhttps://string-db.org/network/9606.ENSP00000277225Zinc finger protein 462; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic ste [...]
OR1K1 protein networkhttps://string-db.org/network/9606.ENSP00000277309Olfactory receptor 1K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ASB6 protein networkhttps://string-db.org/network/9606.ENSP00000277458Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
IDI2 protein networkhttps://string-db.org/network/9606.ENSP00000277517Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosp [...]
LCN9 protein networkhttps://string-db.org/network/9606.ENSP00000277526Epididymal-specific lipocalin-9; Lipocalin 9.
DPH7 protein networkhttps://string-db.org/network/9606.ENSP00000277540Diphthine methyltransferase; Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine whi [...]
NACC2 protein networkhttps://string-db.org/network/9606.ENSP00000277554Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the r [...]
PROSER2 protein networkhttps://string-db.org/network/9606.ENSP00000277570Proline and serine rich 2.
USP6NL protein networkhttps://string-db.org/network/9606.ENSP00000277575USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrogr [...]
MINDY3 protein networkhttps://string-db.org/network/9606.ENSP00000277632Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
NRBF2 protein networkhttps://string-db.org/network/9606.ENSP00000277746Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
GLUD1 protein networkhttps://string-db.org/network/9606.ENSP00000277865Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-k [...]
ABLIM1 protein networkhttps://string-db.org/network/9606.ENSP00000277895Actin-binding LIM protein 1; May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.
HABP2 protein networkhttps://string-db.org/network/9606.ENSP00000277903Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen an [...]
NPFFR1 protein networkhttps://string-db.org/network/9606.ENSP00000277942Neuropeptide FF receptor 1; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occu [...]
FUOM protein networkhttps://string-db.org/network/9606.ENSP00000278025Fucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is [...]
PAOX protein networkhttps://string-db.org/network/9606.ENSP00000278060Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can als [...]
PPRC1 protein networkhttps://string-db.org/network/9606.ENSP00000278070Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and ce [...]
ITPRIP protein networkhttps://string-db.org/network/9606.ENSP00000278071Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release.
LIN7C protein networkhttps://string-db.org/network/9606.ENSP00000278193Protein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...]
LRRC4C protein networkhttps://string-db.org/network/9606.ENSP00000278198Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons.
IMMP1L protein networkhttps://string-db.org/network/9606.ENSP00000278200Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into th [...]
SAA4 protein networkhttps://string-db.org/network/9606.ENSP00000278222Serum amyloid A-4 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family.
PGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000278243Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similari [...]
SCGB1A1 protein networkhttps://string-db.org/network/9606.ENSP00000278282Uteroglobin; Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
ZNF214 protein networkhttps://string-db.org/network/9606.ENSP00000278314Zinc finger protein 214; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF215 protein networkhttps://string-db.org/network/9606.ENSP00000278319Zinc finger protein 215; May be involved in transcriptional regulation.
HSD17B12 protein networkhttps://string-db.org/network/9606.ENSP00000278353Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the [...]
SLC1A2 protein networkhttps://string-db.org/network/9606.ENSP00000278379Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...]
SERPING1 protein networkhttps://string-db.org/network/9606.ENSP00000278407Plasma protease C1 inhibitor; Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May pla [...]
OR5F1 protein networkhttps://string-db.org/network/9606.ENSP00000278409Olfactory receptor 5F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SSRP1 protein networkhttps://string-db.org/network/9606.ENSP00000278412FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a [...]
TMX2 protein networkhttps://string-db.org/network/9606.ENSP00000278422Thioredoxin related transmembrane protein 2.
SLC43A1 protein networkhttps://string-db.org/network/9606.ENSP00000278426Large neutral amino acids transporter small subunit 3; Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 a [...]
HIKESHI protein networkhttps://string-db.org/network/9606.ENSP00000278483Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins i [...]
ENDOD1 protein networkhttps://string-db.org/network/9606.ENSP00000278505Endonuclease domain-containing 1 protein; May act as a DNase and a RNase; Belongs to the DNA/RNA non-specific endonuclease family.
TENM4 protein networkhttps://string-db.org/network/9606.ENSP00000278550Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during [...]
PAK1 protein networkhttps://string-db.org/network/9606.ENSP00000278568Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton d [...]
RPS3 protein networkhttps://string-db.org/network/9606.ENSP0000027857240S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bo [...]
ZC3H12C protein networkhttps://string-db.org/network/9606.ENSP00000278590Probable ribonuclease ZC3H12C; May function as RNase and regulate the levels of target RNA species; Belongs to the ZC3H12 family.
C11orf52 protein networkhttps://string-db.org/network/9606.ENSP00000278601Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52.
NPAT protein networkhttps://string-db.org/network/9606.ENSP00000278612Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 gene [...]
ATM protein networkhttps://string-db.org/network/9606.ENSP00000278616Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A l [...]
AASDHPPT protein networkhttps://string-db.org/network/9606.ENSP00000278618L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopante [...]
LAMTOR1 protein networkhttps://string-db.org/network/9606.ENSP00000278671Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...]
ST14 protein networkhttps://string-db.org/network/9606.ENSP00000278742Suppressor of tumorigenicity 14 protein; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of [...]
OVOL2 protein networkhttps://string-db.org/network/9606.ENSP00000278780Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal tran [...]
MTA2 protein networkhttps://string-db.org/network/9606.ENSP00000278823Metastasis-associated protein MTA2; May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
TMEM138 protein networkhttps://string-db.org/network/9606.ENSP00000278826Transmembrane protein 138; Required for ciliogenesis.
FADS3 protein networkhttps://string-db.org/network/9606.ENSP00000278829Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fat [...]
ROM1 protein networkhttps://string-db.org/network/9606.ENSP00000278833Rod outer segment membrane protein 1; Plays a role in rod outer segment (ROS) morphogenesis (By similarity). May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By [...]
MYRF protein networkhttps://string-db.org/network/9606.ENSP00000278836Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory fact [...]
FADS2 protein networkhttps://string-db.org/network/9606.ENSP00000278840Acyl-CoA 6-desaturase; Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty [...]
ZP1 protein networkhttps://string-db.org/network/9606.ENSP00000278853Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and [...]
OOSP2 protein networkhttps://string-db.org/network/9606.ENSP00000278855Oocyte secreted protein 2.
MS4A3 protein networkhttps://string-db.org/network/9606.ENSP00000278865Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through it [...]
NINL protein networkhttps://string-db.org/network/9606.ENSP00000278886Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell peripher [...]
MS4A2 protein networkhttps://string-db.org/network/9606.ENSP00000278888High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required [...]
EI24 protein networkhttps://string-db.org/network/9606.ENSP00000278903Etoposide-induced protein 2.4 homolog; Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity); B [...]
ESAM protein networkhttps://string-db.org/network/9606.ENSP00000278927Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction.
CEP164 protein networkhttps://string-db.org/network/9606.ENSP00000278935Centrosomal protein of 164 kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface [...]
MPZL2 protein networkhttps://string-db.org/network/9606.ENSP00000278937Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion.
SCN2B protein networkhttps://string-db.org/network/9606.ENSP00000278947Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the pla [...]
MPZL3 protein networkhttps://string-db.org/network/9606.ENSP00000278949Myelin protein zero-like protein 3; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family.
DUSP15 protein networkhttps://string-db.org/network/9606.ENSP00000278979Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfam [...]
COMMD7 protein networkhttps://string-db.org/network/9606.ENSP00000278980COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity.
MYL9 protein networkhttps://string-db.org/network/9606.ENSP00000279022Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. [...]
KIAA1755 protein networkhttps://string-db.org/network/9606.ENSP00000279024Uncharacterized protein KIAA1755; KIAA1755.
SLC13A3 protein networkhttps://string-db.org/network/9606.ENSP00000279027Solute carrier family 13 member 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetyl [...]
OCSTAMP protein networkhttps://string-db.org/network/9606.ENSP00000279028Osteoclast stimulatory transmembrane protein; Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion [...]
PIGT protein networkhttps://string-db.org/network/9606.ENSP00000279036GPI transamidase component PIG-T; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
SPINT4 protein networkhttps://string-db.org/network/9606.ENSP00000279058Serine peptidase inhibitor, Kunitz type 4.
LSM14B protein networkhttps://string-db.org/network/9606.ENSP00000279068Protein LSM14 homolog B; May play a role in control of mRNA translation.
CABLES2 protein networkhttps://string-db.org/network/9606.ENSP00000279101CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition; Belongs to the cyclin family.
AIP protein networkhttps://string-db.org/network/9606.ENSP00000279146AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targetin [...]
LTO1 protein networkhttps://string-db.org/network/9606.ENSP00000279147Protein LTO1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be r [...]
GPHA2 protein networkhttps://string-db.org/network/9606.ENSP00000279168Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP pro [...]
SLC22A9 protein networkhttps://string-db.org/network/9606.ENSP00000279178Solute carrier family 22 member 9; Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specificall [...]
NUDT22 protein networkhttps://string-db.org/network/9606.ENSP00000279206Uridine diphosphate glucose pyrophosphatase NUDT22; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose; B [...]
FERMT3 protein networkhttps://string-db.org/network/9606.ENSP00000279227Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-m [...]
MRPL49 protein networkhttps://string-db.org/network/9606.ENSP00000279242Mitochondrial ribosomal protein L49.
CDC42EP2 protein networkhttps://string-db.org/network/9606.ENSP00000279249Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...]
TM7SF2 protein networkhttps://string-db.org/network/9606.ENSP00000279263Delta(14)-sterol reductase TM7SF2; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
VPS51 protein networkhttps://string-db.org/network/9606.ENSP00000279281Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...]
PPP4C protein networkhttps://string-db.org/network/9606.ENSP00000279387Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs [...]
HIRIP3 protein networkhttps://string-db.org/network/9606.ENSP00000279392HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
MMP10 protein networkhttps://string-db.org/network/9606.ENSP00000279441Stromelysin-2; Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase; Belongs to the peptidase M10A family.
DUSP6 protein networkhttps://string-db.org/network/9606.ENSP00000279488Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal [...]
PRB4 protein networkhttps://string-db.org/network/9606.ENSP00000279575Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4.
OR8K1 protein networkhttps://string-db.org/network/9606.ENSP00000279783Olfactory receptor 8K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5M9 protein networkhttps://string-db.org/network/9606.ENSP00000279791Olfactory receptor 5M9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CTF1 protein networkhttps://string-db.org/network/9606.ENSP00000279804Cardiotrophin-1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
ARID5B protein networkhttps://string-db.org/network/9606.ENSP00000279873AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by form [...]
UHRF1BP1L protein networkhttps://string-db.org/network/9606.ENSP00000279907UHRF1-binding protein 1-like; UHRF1 binding protein 1 like.
KIAA1328 protein networkhttps://string-db.org/network/9606.ENSP00000280020Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes.
FAM124A protein networkhttps://string-db.org/network/9606.ENSP00000280057Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family.
HNMT protein networkhttps://string-db.org/network/9606.ENSP00000280097Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
SPOPL protein networkhttps://string-db.org/network/9606.ENSP00000280098Speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of [...]
PDCD4 protein networkhttps://string-db.org/network/9606.ENSP00000280154Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicas [...]
ADRA2A protein networkhttps://string-db.org/network/9606.ENSP00000280155Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agoni [...]
GPM6A protein networkhttps://string-db.org/network/9606.ENSP00000280187Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in n [...]
WDR17 protein networkhttps://string-db.org/network/9606.ENSP00000280190WD repeat domain 17.
SPATA4 protein networkhttps://string-db.org/network/9606.ENSP00000280191Spermatogenesis-associated protein 4; May play a role in apoptosis regulation.
FSIP1 protein networkhttps://string-db.org/network/9606.ENSP00000280236Fibrous sheath interacting protein 1; Belongs to the FSIP1 family.
CCDC83 protein networkhttps://string-db.org/network/9606.ENSP00000280245Coiled-coil domain containing 83.
PRSS23 protein networkhttps://string-db.org/network/9606.ENSP00000280258Serine protease 23; Belongs to the peptidase S1 family.
PPP1R1C protein networkhttps://string-db.org/network/9606.ENSP00000280295Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis.
CCT5 protein networkhttps://string-db.org/network/9606.ENSP00000280326T-complex protein 1 subunit epsilon; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC comp [...]
DLAT protein networkhttps://string-db.org/network/9606.ENSP00000280346Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby link [...]
PIH1D2 protein networkhttps://string-db.org/network/9606.ENSP00000280350PIH1 domain containing 2.
IL18 protein networkhttps://string-db.org/network/9606.ENSP00000280357Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, for [...]
TEX12 protein networkhttps://string-db.org/network/9606.ENSP00000280358Testis-expressed protein 12; Testis expressed 12.
PTS protein networkhttps://string-db.org/network/9606.ENSP000002803626-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydr [...]
USP15 protein networkhttps://string-db.org/network/9606.ENSP00000280377Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and R [...]
FREM2 protein networkhttps://string-db.org/network/9606.ENSP00000280481FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. Required for ep [...]
CRIM1 protein networkhttps://string-db.org/network/9606.ENSP00000280527Processed cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in c [...]
SEC24D protein networkhttps://string-db.org/network/9606.ENSP00000280551Protein transport protein Sec24D; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
DENR protein networkhttps://string-db.org/network/9606.ENSP00000280557Density-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of amin [...]
RILPL2 protein networkhttps://string-db.org/network/9606.ENSP00000280571RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular prote [...]
TKTL2 protein networkhttps://string-db.org/network/9606.ENSP00000280605Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activit [...]
PRSS53 protein networkhttps://string-db.org/network/9606.ENSP00000280606Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator.
SLC7A11 protein networkhttps://string-db.org/network/9606.ENSP00000280612Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. Belongs to the amino acid-polyami [...]
NOCT protein networkhttps://string-db.org/network/9606.ENSP00000280614Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of [...]
DCP1B protein networkhttps://string-db.org/network/9606.ENSP00000280665mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA m [...]
KCNA6 protein networkhttps://string-db.org/network/9606.ENSP00000280684Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective [...]
NGLY1 protein networkhttps://string-db.org/network/9606.ENSP00000280700Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degrad [...]
OXSM protein networkhttps://string-db.org/network/9606.ENSP000002807013-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belon [...]
LDHAL6A protein networkhttps://string-db.org/network/9606.ENSP00000280706L-lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed.
TMEM86A protein networkhttps://string-db.org/network/9606.ENSP00000280734Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A.
BTBD11 protein networkhttps://string-db.org/network/9606.ENSP00000280758Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; BTB domain containing 11.
ANK3 protein networkhttps://string-db.org/network/9606.ENSP00000280772Ankyrin-3; In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels [...]
PLBD2 protein networkhttps://string-db.org/network/9606.ENSP00000280800Putative phospholipase B-like 2 32 kDa form; Putative phospholipase.
SLC2A13 protein networkhttps://string-db.org/network/9606.ENSP00000280871Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
DIP2C protein networkhttps://string-db.org/network/9606.ENSP00000280886Disco interacting protein 2 homolog C.
DSC2 protein networkhttps://string-db.org/network/9606.ENSP00000280904Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...]
AKAP6 protein networkhttps://string-db.org/network/9606.ENSP00000280979A-kinase anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assemblin [...]
FAM177A1 protein networkhttps://string-db.org/network/9606.ENSP00000280987Protein FAM177A1; Family with sequence similarity 177 member A1.
THRSP protein networkhttps://string-db.org/network/9606.ENSP00000281030Thyroid hormone-inducible hepatic protein; Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length [...]
NDUFC2 protein networkhttps://string-db.org/network/9606.ENSP00000281031NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. C [...]
NARS2 protein networkhttps://string-db.org/network/9606.ENSP00000281038Probable asparagine--tRNA ligase, mitochondrial; asparaginyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family.
MYCN protein networkhttps://string-db.org/network/9606.ENSP00000281043N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells.
MSGN1 protein networkhttps://string-db.org/network/9606.ENSP00000281047Mesogenin-1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By simi [...]
NUBPL protein networkhttps://string-db.org/network/9606.ENSP00000281081Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits [...]
FER protein networkhttps://string-db.org/network/9606.ENSP00000281092Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule as [...]
CDC123 protein networkhttps://string-db.org/network/9606.ENSP00000281141Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle.
SCLT1 protein networkhttps://string-db.org/network/9606.ENSP00000281142Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity).
C4orf33 protein networkhttps://string-db.org/network/9606.ENSP00000281146UPF0462 protein C4orf33; Chromosome 4 open reading frame 33.
SLC25A31 protein networkhttps://string-db.org/network/9606.ENSP00000281154ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming proces [...]
KHDRBS2 protein networkhttps://string-db.org/network/9606.ENSP00000281156KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site select [...]
PTPRO protein networkhttps://string-db.org/network/9606.ENSP00000281171Receptor-type tyrosine-protein phosphatase O; Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyt [...]
ACAD8 protein networkhttps://string-db.org/network/9606.ENSP00000281182Isobutyryl-CoA dehydrogenase, mitochondrial; Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidat [...]
VPS26B protein networkhttps://string-db.org/network/9606.ENSP00000281187Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...]
QDPR protein networkhttps://string-db.org/network/9606.ENSP00000281243Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain d [...]
CGNL1 protein networkhttps://string-db.org/network/9606.ENSP00000281282Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.
POU4F2 protein networkhttps://string-db.org/network/9606.ENSP00000281321POU domain, class 4, transcription factor 2; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or rep [...]
PIGF protein networkhttps://string-db.org/network/9606.ENSP00000281382Phosphatidylinositol-glycan biosynthesis class F protein; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI.
ASAP2 protein networkhttps://string-db.org/network/9606.ENSP00000281419Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive [...]
BARX2 protein networkhttps://string-db.org/network/9606.ENSP00000281437Homeobox protein BarH-like 2; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM [...]
TMEM45B protein networkhttps://string-db.org/network/9606.ENSP00000281441Transmembrane protein 45B.
CENPU protein networkhttps://string-db.org/network/9606.ENSP00000281453Centromere protein U; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
SLC25A4 protein networkhttps://string-db.org/network/9606.ENSP00000281456ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
AMN1 protein networkhttps://string-db.org/network/9606.ENSP00000281471Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog.
NBAS protein networkhttps://string-db.org/network/9606.ENSP00000281513Neuroblastoma-amplified sequence; Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed [...]
ZNF385D protein networkhttps://string-db.org/network/9606.ENSP00000281523Zinc finger protein 385D.
GUF1 protein networkhttps://string-db.org/network/9606.ENSP00000281543Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRN [...]
PABPC3 protein networkhttps://string-db.org/network/9606.ENSP00000281589Polyadenylate-binding protein 3; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared t [...]
FBXO4 protein networkhttps://string-db.org/network/9606.ENSP00000281623F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradatio [...]
PARP8 protein networkhttps://string-db.org/network/9606.ENSP00000281631Protein mono-ADP-ribosyltransferase PARP8; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins.
NVL protein networkhttps://string-db.org/network/9606.ENSP00000281701Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and l [...]
GLT1D1 protein networkhttps://string-db.org/network/9606.ENSP00000281703Glycosyltransferase 1 domain containing 1; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
RBM46 protein networkhttps://string-db.org/network/9606.ENSP00000281722RNA binding motif protein 46.
TXNDC16 protein networkhttps://string-db.org/network/9606.ENSP00000281741Thioredoxin domain containing 16.
KANSL1L protein networkhttps://string-db.org/network/9606.ENSP00000281772KAT8 regulatory NSL complex subunit 1 like.
MCHR2 protein networkhttps://string-db.org/network/9606.ENSP00000281806Melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
EPHA4 protein networkhttps://string-db.org/network/9606.ENSP00000281821Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbori [...]
FARSB protein networkhttps://string-db.org/network/9606.ENSP00000281828phenylalanyl-tRNA synthetase subunit beta; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
KCNE4 protein networkhttps://string-db.org/network/9606.ENSP00000281830Potassium voltage-gated channel subfamily E member 4; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...]
TNFSF4 protein networkhttps://string-db.org/network/9606.ENSP00000281834Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
CFC1B protein networkhttps://string-db.org/network/9606.ENSP00000281882Cripto, FRL-1, cryptic family 1B.
MGAT5 protein networkhttps://string-db.org/network/9606.ENSP00000281923Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of bianten [...]
TMEM163 protein networkhttps://string-db.org/network/9606.ENSP00000281924Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles.
MED13L protein networkhttps://string-db.org/network/9606.ENSP00000281928Mediator of RNA polymerase II transcription subunit 13-like; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent gen [...]
HSPB8 protein networkhttps://string-db.org/network/9606.ENSP00000281938Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family.
GEMIN6 protein networkhttps://string-db.org/network/9606.ENSP00000281950Gem-associated protein 6; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...]
TMEM178A protein networkhttps://string-db.org/network/9606.ENSP00000281961Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the i [...]
OBI1 protein networkhttps://string-db.org/network/9606.ENSP00000282003ORC ubiquitin ligase 1; E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyz [...]
CYSLTR2 protein networkhttps://string-db.org/network/9606.ENSP00000282018Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation [...]
GRID2 protein networkhttps://string-db.org/network/9606.ENSP00000282020Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu [...]
ARL11 protein networkhttps://string-db.org/network/9606.ENSP00000282026ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor. Belongs to the small GTPase superfamily. Arf family.
ARL14EP protein networkhttps://string-db.org/network/9606.ENSP00000282032ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicl [...]
EPG5 protein networkhttps://string-db.org/network/9606.ENSP00000282041Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune [...]
HAUS1 protein networkhttps://string-db.org/network/9606.ENSP00000282058HAUS augmin-like complex subunit 1; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
SPC25 protein networkhttps://string-db.org/network/9606.ENSP00000282074Kinetochore protein Spc25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for ki [...]
PDE3B protein networkhttps://string-db.org/network/9606.ENSP00000282096cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important ph [...]
TCF7L1 protein networkhttps://string-db.org/network/9606.ENSP00000282111Transcription factor 7-like 1; Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the ter [...]
CRYGC protein networkhttps://string-db.org/network/9606.ENSP00000282141Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
KCNK13 protein networkhttps://string-db.org/network/9606.ENSP00000282146Potassium channel subfamily K member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
ATG10 protein networkhttps://string-db.org/network/9606.ENSP00000282185Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for [...]
FAM151B protein networkhttps://string-db.org/network/9606.ENSP00000282226Protein FAM151B; Family with sequence similarity 151 member B.
GUCY1A2 protein networkhttps://string-db.org/network/9606.ENSP00000282249Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit.
CWF19L2 protein networkhttps://string-db.org/network/9606.ENSP00000282251CWF19-like protein 2; CWF19 like cell cycle control factor 2; Belongs to the CWF19 family.
ANKRD44 protein networkhttps://string-db.org/network/9606.ENSP00000282272Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...]
MARS2 protein networkhttps://string-db.org/network/9606.ENSP00000282276Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial.
ZNF547 protein networkhttps://string-db.org/network/9606.ENSP00000282282Zinc finger protein 547; May be involved in transcriptional regulation.
ZNF773 protein networkhttps://string-db.org/network/9606.ENSP00000282292Zinc finger protein 773; May be involved in transcriptional regulation.
ZNF551 protein networkhttps://string-db.org/network/9606.ENSP00000282296Zinc finger protein 551; May be involved in transcriptional regulation.
ZNF256 protein networkhttps://string-db.org/network/9606.ENSP00000282308Zinc finger protein 256; Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Belongs to the krueppel C2H2-type zinc-finger protein family.
ZSCAN1 protein networkhttps://string-db.org/network/9606.ENSP00000282326Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation.
USP12 protein networkhttps://string-db.org/network/9606.ENSP00000282344Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not [...]
CAMK4 protein networkhttps://string-db.org/network/9606.ENSP00000282356Calcium/calmodulin-dependent protein kinase type IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phos [...]
TRIM36 protein networkhttps://string-db.org/network/9606.ENSP00000282369E3 ubiquitin-protein ligase TRIM36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cel [...]
TMED7-TICAM2 protein networkhttps://string-db.org/network/9606.ENSP00000282382TMED7-TICAM2 readthrough.
ZFP36L2 protein networkhttps://string-db.org/network/9606.ENSP00000282388mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail remov [...]
FLT1 protein networkhttps://string-db.org/network/9606.ENSP00000282397Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic v [...]
PLEKHH2 protein networkhttps://string-db.org/network/9606.ENSP00000282406Pleckstrin homology domain-containing family H member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabil [...]
PPM1B protein networkhttps://string-db.org/network/9606.ENSP00000282412Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1- mediated antiviral signaling by dephosphorylat [...]
IGSF10 protein networkhttps://string-db.org/network/9606.ENSP00000282466Immunoglobulin superfamily member 10; Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the mainte [...]
MBNL1 protein networkhttps://string-db.org/network/9606.ENSP00000282486Muscleblind-like protein 1; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...]
GRIA4 protein networkhttps://string-db.org/network/9606.ENSP00000282499Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...]
UGT3A2 protein networkhttps://string-db.org/network/9606.ENSP00000282507UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...]
NIPBL protein networkhttps://string-db.org/network/9606.ENSP00000282516Nipped-B-like protein; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates [...]
GADL1 protein networkhttps://string-db.org/network/9606.ENSP00000282538Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, res [...]
GPD1L protein networkhttps://string-db.org/network/9606.ENSP00000282541Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3- phosphate activat [...]
GJA1 protein networkhttps://string-db.org/network/9606.ENSP00000282561Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connex [...]
GMCL1 protein networkhttps://string-db.org/network/9606.ENSP00000282570Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By si [...]
CCNO protein networkhttps://string-db.org/network/9606.ENSP00000282572Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS t [...]
ITGA1 protein networkhttps://string-db.org/network/9606.ENSP00000282588Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negativ [...]
JADE2 protein networkhttps://string-db.org/network/9606.ENSP00000282605E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk [...]
CATSPER3 protein networkhttps://string-db.org/network/9606.ENSP00000282611Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...]
WASHC2A protein networkhttps://string-db.org/network/9606.ENSP00000282633WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recrui [...]
TCTEX1D1 protein networkhttps://string-db.org/network/9606.ENSP00000282670Tctex1 domain containing 1.
BMP3 protein networkhttps://string-db.org/network/9606.ENSP00000282701Bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
HHEX protein networkhttps://string-db.org/network/9606.ENSP00000282728Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior ident [...]
GRM1 protein networkhttps://string-db.org/network/9606.ENSP00000282753Metabotropic glutamate receptor 1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
GGPS1 protein networkhttps://string-db.org/network/9606.ENSP00000282841Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and gerany [...]
ADAMTS18 protein networkhttps://string-db.org/network/9606.ENSP00000282849ADAM metallopeptidase with thrombospondin type 1 motif 18.
ZNF117 protein networkhttps://string-db.org/network/9606.ENSP00000282869Zinc finger protein 117; May be involved in transcriptional regulation.
RAB3C protein networkhttps://string-db.org/network/9606.ENSP00000282878Ras-related protein Rab-3C; Protein transport. Probably involved in vesicular traffic (By similarity).
MED21 protein networkhttps://string-db.org/network/9606.ENSP00000282892Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
PLOD2 protein networkhttps://string-db.org/network/9606.ENSP00000282903Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units a [...]
STK32B protein networkhttps://string-db.org/network/9606.ENSP00000282908Serine/threonine kinase 32B.
ZIC1 protein networkhttps://string-db.org/network/9606.ENSP00000282928Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cor [...]
CENPH protein networkhttps://string-db.org/network/9606.ENSP00000283006Centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
TEKT5 protein networkhttps://string-db.org/network/9606.ENSP00000283025Tektin-5; May be a structural component of the sperm flagellum.
NUBP1 protein networkhttps://string-db.org/network/9606.ENSP00000283027Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP [...]
RIOK2 protein networkhttps://string-db.org/network/9606.ENSP00000283109Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosom [...]
SMARCA5 protein networkhttps://string-db.org/network/9606.ENSP00000283131SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome- remodeling activity. Complexes containin [...]
SYCP2L protein networkhttps://string-db.org/network/9606.ENSP00000283141Synaptonemal complex protein 2-like; Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Belongs to the SYCP2 family.
BMP6 protein networkhttps://string-db.org/network/9606.ENSP00000283147Bone morphogenetic protein 6; Induces cartilage and bone formation.
UXS1 protein networkhttps://string-db.org/network/9606.ENSP00000283148UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminogly [...]
RANBP2 protein networkhttps://string-db.org/network/9606.ENSP00000283195E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F [...]
TMEM87B protein networkhttps://string-db.org/network/9606.ENSP00000283206Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN); Belongs to the LU7TM family. TMEM87 subfamily.
OR14K1 protein networkhttps://string-db.org/network/9606.ENSP00000283225Olfactory receptor 14K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PTPRR protein networkhttps://string-db.org/network/9606.ENSP00000283228Receptor-type tyrosine-protein phosphatase R; Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephos [...]
CCDC148 protein networkhttps://string-db.org/network/9606.ENSP00000283233Coiled-coil domain containing 148.
PLA2R1 protein networkhttps://string-db.org/network/9606.ENSP00000283243Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to [...]
ITGB6 protein networkhttps://string-db.org/network/9606.ENSP00000283249Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 vi [...]
SCN3A protein networkhttps://string-db.org/network/9606.ENSP00000283254Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
FEZF2 protein networkhttps://string-db.org/network/9606.ENSP00000283268Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neu [...]
CD96 protein networkhttps://string-db.org/network/9606.ENSP00000283285T-cell surface protein tactile; May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting [...]
ATG3 protein networkhttps://string-db.org/network/9606.ENSP00000283290Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent [...]
ADGRF5 protein networkhttps://string-db.org/network/9606.ENSP00000283296Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. Belongs to the G-protein coupled rec [...]
ADGRF4 protein networkhttps://string-db.org/network/9606.ENSP00000283303Adhesion G protein-coupled receptor F4; Orphan receptor.
FRMD1 protein networkhttps://string-db.org/network/9606.ENSP00000283309FERM domain containing 1.
TRAPPC8 protein networkhttps://string-db.org/network/9606.ENSP00000283351Trafficking protein particle complex subunit 8; Plays a role in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Maintains together with TBC1D14 the cycling pool of ATG [...]
FAM81B protein networkhttps://string-db.org/network/9606.ENSP00000283357Protein FAM81B; Family with sequence similarity 81 member B.
LPCAT1 protein networkhttps://string-db.org/network/9606.ENSP00000283415Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium- independent (By similarity). Mediates the conversion of 1-acyl-sn- [...]
ZDHHC11 protein networkhttps://string-db.org/network/9606.ENSP00000283441Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family.
UBALD1 protein networkhttps://string-db.org/network/9606.ENSP00000283474UBA-like domain-containing protein 1; UBA like domain containing 1.
TEX29 protein networkhttps://string-db.org/network/9606.ENSP00000283547Testis-expressed protein 29; Testis expressed 29.
SPACA7 protein networkhttps://string-db.org/network/9606.ENSP00000283550Sperm acrosome-associated protein 7; Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.
UBP1 protein networkhttps://string-db.org/network/9606.ENSP00000283629Upstream-binding protein 1; Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-glo [...]
RMND5A protein networkhttps://string-db.org/network/9606.ENSP00000283632E3 ubiquitin-protein transferase RMND5A; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent pr [...]
RPIA protein networkhttps://string-db.org/network/9606.ENSP00000283646Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family.
VILL protein networkhttps://string-db.org/network/9606.ENSP00000283713Villin-like protein; Possible tumor suppressor.
SERPINB3 protein networkhttps://string-db.org/network/9606.ENSP00000283752Serpin B3; May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of [...]
HGD protein networkhttps://string-db.org/network/9606.ENSP00000283871Homogentisate 1,2-dioxygenase.
GTF2E1 protein networkhttps://string-db.org/network/9606.ENSP00000283875General transcription factor IIE subunit 1; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Bo [...]
CFDP1 protein networkhttps://string-db.org/network/9606.ENSP00000283882Craniofacial development protein 1; May play a role during embryogenesis.
C7orf31 protein networkhttps://string-db.org/network/9606.ENSP00000283905Uncharacterized protein C7orf31; Chromosome 7 open reading frame 31.
TMPRSS11D protein networkhttps://string-db.org/network/9606.ENSP00000283916Transmembrane protease serine 11D non-catalytic chain; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in [...]
HOXA10 protein networkhttps://string-db.org/network/9606.ENSP00000283921Homeobox protein Hox-A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
JAZF1 protein networkhttps://string-db.org/network/9606.ENSP00000283928Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of [...]
PID1 protein networkhttps://string-db.org/network/9606.ENSP00000283937PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation.
FBXO36 protein networkhttps://string-db.org/network/9606.ENSP00000283946F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
DDAH1 protein networkhttps://string-db.org/network/9606.ENSP00000284031N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in [...]
DGKE protein networkhttps://string-db.org/network/9606.ENSP00000284061Diacylglycerol kinase epsilon; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the sy [...]
MSI2 protein networkhttps://string-db.org/network/9606.ENSP00000284073RNA-binding protein Musashi homolog 2; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cel [...]
HS3ST3A1 protein networkhttps://string-db.org/network/9606.ENSP00000284110Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosam [...]
GDPD1 protein networkhttps://string-db.org/network/9606.ENSP00000284116Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (l [...]
SEMA3D protein networkhttps://string-db.org/network/9606.ENSP00000284136Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity).
ASB17 protein networkhttps://string-db.org/network/9606.ENSP00000284142Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
GRAP protein networkhttps://string-db.org/network/9606.ENSP00000284154GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing.
IMPACT protein networkhttps://string-db.org/network/9606.ENSP00000284202Protein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor [...]
THY1 protein networkhttps://string-db.org/network/9606.ENSP00000284240Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
C16orf74 protein networkhttps://string-db.org/network/9606.ENSP00000284245Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74.
JPH3 protein networkhttps://string-db.org/network/9606.ENSP00000284262Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...]
ANKH protein networkhttps://string-db.org/network/9606.ENSP00000284268Progressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family.
UBASH3B protein networkhttps://string-db.org/network/9606.ENSP00000284273Ubiquitin-associated and SH3 domain-containing protein B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target [...]
OTULIN protein networkhttps://string-db.org/network/9606.ENSP00000284274Ubiquitin thioesterase otulin; Deubiquitinase that specifically removes linear ('Met-1'- linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune respo [...]
PANX3 protein networkhttps://string-db.org/network/9606.ENSP00000284288Pannexin-3; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.
NRGN protein networkhttps://string-db.org/network/9606.ENSP00000284292NEUG(55-78); Acts as a 'third messenger' substrate of protein kinase C- mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By s [...]
GPR15 protein networkhttps://string-db.org/network/9606.ENSP00000284311G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; Belongs to the G-protein coupled receptor 1 family.
TOMM70 protein networkhttps://string-db.org/network/9606.ENSP00000284320Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins.
ABI3BP protein networkhttps://string-db.org/network/9606.ENSP00000284322Target of Nesh-SH3; ABI family member 3 binding protein.
CERS3 protein networkhttps://string-db.org/network/9606.ENSP00000284382Ceramide synthase 3; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) and ultra long chain (m [...]
ABCA6 protein networkhttps://string-db.org/network/9606.ENSP00000284425ATP-binding cassette sub-family A member 6; Probable transporter which may play a role in macrophage lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family.
UCHL1 protein networkhttps://string-db.org/network/9606.ENSP00000284440Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a th [...]
DISP1 protein networkhttps://string-db.org/network/9606.ENSP00000284476Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effect [...]
FAM167A protein networkhttps://string-db.org/network/9606.ENSP00000284486Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family.
NEIL2 protein networkhttps://string-db.org/network/9606.ENSP00000284503Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of [...]
ATP8B4 protein networkhttps://string-db.org/network/9606.ENSP00000284509Probable phospholipid-transporting ATPase IM; Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
WNT3A protein networkhttps://string-db.org/network/9606.ENSP00000284523Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription [...]
TRIM11 protein networkhttps://string-db.org/network/9606.ENSP00000284551E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly- [...]
PPP1R3A protein networkhttps://string-db.org/network/9606.ENSP00000284601Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, m [...]
CCSAP protein networkhttps://string-db.org/network/9606.ENSP00000284617Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with pol [...]
ASZ1 protein networkhttps://string-db.org/network/9606.ENSP00000284629Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which [...]
SH3RF1 protein networkhttps://string-db.org/network/9606.ENSP00000284637E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium [...]
KLHL41 protein networkhttps://string-db.org/network/9606.ENSP00000284669Kelch-like protein 41; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting la [...]
GPR26 protein networkhttps://string-db.org/network/9606.ENSP00000284674G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in [...]
DHX32 protein networkhttps://string-db.org/network/9606.ENSP00000284690Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily.
C10orf90 protein networkhttps://string-db.org/network/9606.ENSP00000284694(E2-independent) E3 ubiquitin-conjugating enzyme FATS; Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p5 [...]
OLA1 protein networkhttps://string-db.org/network/9606.ENSP00000284719Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. Y [...]
ATP5MC3 protein networkhttps://string-db.org/network/9606.ENSP00000284727ATP synthase F(0) complex subunit C3, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...]
PDLIM3 protein networkhttps://string-db.org/network/9606.ENSP00000284767PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells.
LY96 protein networkhttps://string-db.org/network/9606.ENSP00000284818Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wa [...]
TMSB4Y protein networkhttps://string-db.org/network/9606.ENSP00000284856Thymosin beta-4, Y-chromosomal; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By s [...]
CXADR protein networkhttps://string-db.org/network/9606.ENSP00000284878Coxsackievirus and adenovirus receptor; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. [...]
C21orf91 protein networkhttps://string-db.org/network/9606.ENSP00000284881Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating [...]
TMPRSS15 protein networkhttps://string-db.org/network/9606.ENSP00000284885Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion o [...]
APP protein networkhttps://string-db.org/network/9606.ENSP00000284981Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axono [...]
ADAMTS1 protein networkhttps://string-db.org/network/9606.ENSP00000284984A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938- Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain) [...]
ADAMTS5 protein networkhttps://string-db.org/network/9606.ENSP00000284987A disintegrin and metalloproteinase with thrombospondin motifs 5; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell [...]
TSEN2 protein networkhttps://string-db.org/network/9606.ENSP00000284995tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the spli [...]
SLFN13 protein networkhttps://string-db.org/network/9606.ENSP00000285013Schlafen family member 13; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. Does not act on tRNA(Sec). Able to restrict HIV-1 [...]
WNT7A protein networkhttps://string-db.org/network/9606.ENSP00000285018Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important [...]
XPC protein networkhttps://string-db.org/network/9606.ENSP00000285021DNA repair protein complementing XP-C cells; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has onl [...]
MYO5B protein networkhttps://string-db.org/network/9606.ENSP00000285039Unconventional myosin-Vb; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not fo [...]
FGD5 protein networkhttps://string-db.org/network/9606.ENSP00000285046FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 acti [...]
FLCN protein networkhttps://string-db.org/network/9606.ENSP00000285071Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.
ACAA2 protein networkhttps://string-db.org/network/9606.ENSP000002850933-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic pro [...]
SKA1 protein networkhttps://string-db.org/network/9606.ENSP00000285116Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Require [...]
USP43 protein networkhttps://string-db.org/network/9606.ENSP00000285199Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that [...]
RAB6B protein networkhttps://string-db.org/network/9606.ENSP00000285208Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells; Belongs to the small GTP [...]
ABCC3 protein networkhttps://string-db.org/network/9606.ENSP00000285238Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export o [...]
ANKRD40 protein networkhttps://string-db.org/network/9606.ENSP00000285243Ankyrin repeat domain 40.
VOPP1 protein networkhttps://string-db.org/network/9606.ENSP00000285279Vesicular, overexpressed in cancer, prosurvival protein 1; Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response [...]
MRPS17 protein networkhttps://string-db.org/network/9606.ENSP00000285298Mitochondrial ribosomal protein S17; Belongs to the universal ribosomal protein uS17 family.
DKK2 protein networkhttps://string-db.org/network/9606.ENSP00000285311Dickkopf-related protein 2; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...]
CA2 protein networkhttps://string-db.org/network/9606.ENSP00000285379Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulati [...]
CA3 protein networkhttps://string-db.org/network/9606.ENSP00000285381Carbonic anhydrase 3; Reversible hydration of carbon dioxide.
ATP6V0D2 protein networkhttps://string-db.org/network/9606.ENSP00000285393V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryot [...]
ERCC3 protein networkhttps://string-db.org/network/9606.ENSP00000285398General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, whic [...]
ODF1 protein networkhttps://string-db.org/network/9606.ENSP00000285402Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of [...]
KLF10 protein networkhttps://string-db.org/network/9606.ENSP00000285407Krueppel-like factor 10; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the p [...]
PIP4P2 protein networkhttps://string-db.org/network/9606.ENSP00000285419Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Do [...]
OTUD6B protein networkhttps://string-db.org/network/9606.ENSP00000285420Deubiquitinase OTUD6B; [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein s [...]
AGPAT5 protein networkhttps://string-db.org/network/9606.ENSP000002855181-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by [...]
MAN2B2 protein networkhttps://string-db.org/network/9606.ENSP00000285599Epididymis-specific alpha-mannosidase; Mannosidase alpha class 2B member 2; Belongs to the glycosyl hydrolase 38 family.
HSPA13 protein networkhttps://string-db.org/network/9606.ENSP00000285667Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.
SAMSN1 protein networkhttps://string-db.org/network/9606.ENSP00000285670SAM domain-containing protein SAMSN-1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization [...]
C16orf87 protein networkhttps://string-db.org/network/9606.ENSP00000285697UPF0547 protein C16orf87; Chromosome 16 open reading frame 87; Belongs to the UPF0547 family.
RHOC protein networkhttps://string-db.org/network/9606.ENSP00000285735Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule [...]
LONP2 protein networkhttps://string-db.org/network/9606.ENSP00000285737Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type [...]
TRIM74 protein networkhttps://string-db.org/network/9606.ENSP00000285805Tripartite motif containing 74; Belongs to the TRIM/RBCC family.
NIFK protein networkhttps://string-db.org/network/9606.ENSP00000285814Nucleolar protein interacting with the FHA domain of MKI67.
OXA1L protein networkhttps://string-db.org/network/9606.ENSP00000285848Mitochondrial inner membrane protein OXA1L; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome o [...]
CCDC146 protein networkhttps://string-db.org/network/9606.ENSP00000285871Coiled-coil domain containing 146.
GEMIN5 protein networkhttps://string-db.org/network/9606.ENSP00000285873Gem-associated protein 5; Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceos [...]
MAGEC1 protein networkhttps://string-db.org/network/9606.ENSP00000285879Melanoma-associated antigen C1; MAGE family member C1.
LRGUK protein networkhttps://string-db.org/network/9606.ENSP00000285928Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspect [...]
AKR1B1 protein networkhttps://string-db.org/network/9606.ENSP00000285930Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity tow [...]
SETD9 protein networkhttps://string-db.org/network/9606.ENSP00000285947SET domain containing 9.
NUP205 protein networkhttps://string-db.org/network/9606.ENSP00000285968Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC.
CYP2C18 protein networkhttps://string-db.org/network/9606.ENSP00000285979Cytochrome P450 2C18; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a va [...]
C1orf112 protein networkhttps://string-db.org/network/9606.ENSP00000286031Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112.
XAGE2 protein networkhttps://string-db.org/network/9606.ENSP00000286049X antigen family member 2.
PDE11A protein networkhttps://string-db.org/network/9606.ENSP00000286063Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolys [...]
RBM45 protein networkhttps://string-db.org/network/9606.ENSP00000286070RNA-binding protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.
PPIL3 protein networkhttps://string-db.org/network/9606.ENSP00000286175Peptidyl-prolyl cis-trans isomerase-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved [...]
CASP10 protein networkhttps://string-db.org/network/9606.ENSP00000286186Caspase-10 subunit p23/17; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May particip [...]
FZD7 protein networkhttps://string-db.org/network/9606.ENSP00000286201Frizzled-7; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK [...]
DEPTOR protein networkhttps://string-db.org/network/9606.ENSP00000286234DEP domain-containing mTOR-interacting protein; Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
SLC26A2 protein networkhttps://string-db.org/network/9606.ENSP00000286298Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation.
CSF1R protein networkhttps://string-db.org/network/9606.ENSP00000286301Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferat [...]
LSM11 protein networkhttps://string-db.org/network/9606.ENSP00000286307U7 snRNA-associated Sm-like protein LSm11; Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone [...]
MED7 protein networkhttps://string-db.org/network/9606.ENSP00000286317Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
TRIM42 protein networkhttps://string-db.org/network/9606.ENSP00000286349Tripartite motif containing 42; Belongs to the TRIM/RBCC family.
PXYLP1 protein networkhttps://string-db.org/network/9606.ENSP000002863532-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosa [...]
ADCY8 protein networkhttps://string-db.org/network/9606.ENSP00000286355Adenylate cyclase type 8; Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secreti [...]
RASA2 protein networkhttps://string-db.org/network/9606.ENSP00000286364Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
ATP1B3 protein networkhttps://string-db.org/network/9606.ENSP00000286371Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...]
SMC2 protein networkhttps://string-db.org/network/9606.ENSP00000286398Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The [...]
TMBIM4 protein networkhttps://string-db.org/network/9606.ENSP00000286424Protein lifeguard 4; Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphos [...]
VBP1 protein networkhttps://string-db.org/network/9606.ENSP00000286428Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
NAT2 protein networkhttps://string-db.org/network/9606.ENSP00000286479Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine s [...]
ELMSAN1 protein networkhttps://string-db.org/network/9606.ENSP00000286523Mitotic deacetylase-associated SANT domain protein.
GNAQ protein networkhttps://string-db.org/network/9606.ENSP00000286548Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regul [...]
WIF1 protein networkhttps://string-db.org/network/9606.ENSP00000286574Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
MMP16 protein networkhttps://string-db.org/network/9606.ENSP00000286614Matrix metalloproteinase-16; Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matr [...]
KCNMA1 protein networkhttps://string-db.org/network/9606.ENSP00000286628Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated [...]
BATF protein networkhttps://string-db.org/network/9606.ENSP00000286639Basic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the [...]
DCK protein networkhttps://string-db.org/network/9606.ENSP00000286648Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not d [...]
ADAMTS3 protein networkhttps://string-db.org/network/9606.ENSP00000286657A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens.
C8orf37 protein networkhttps://string-db.org/network/9606.ENSP00000286688Protein C8orf37; May be involved in photoreceptor outer segment disk morphogenesis (By similarity).
DRAM2 protein networkhttps://string-db.org/network/9606.ENSP00000286692DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to pr [...]
STOM protein networkhttps://string-db.org/network/9606.ENSP00000286713Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family.
PPEF2 protein networkhttps://string-db.org/network/9606.ENSP00000286719Serine/threonine-protein phosphatase with EF-hands 2; May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic curr [...]
CFAP161 protein networkhttps://string-db.org/network/9606.ENSP00000286732Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly.
NAAA protein networkhttps://string-db.org/network/9606.ENSP00000286733N-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoyl [...]
ADAMTSL3 protein networkhttps://string-db.org/network/9606.ENSP00000286744ADAMTS-like protein 3; ADAMTS like 3.
CXCL13 protein networkhttps://string-db.org/network/9606.ENSP00000286758C-X-C motif chemokine 13; Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5.
WHAMM protein networkhttps://string-db.org/network/9606.ENSP00000286760WASP homolog-associated protein with actin, membranes and microtubules; Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatu [...]
CCT8 protein networkhttps://string-db.org/network/9606.ENSP00000286788T-complex protein 1 subunit theta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC comple [...]
NAA11 protein networkhttps://string-db.org/network/9606.ENSP00000286794N-alpha-acetyltransferase 11; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex; Belongs to the a [...]
CLDN17 protein networkhttps://string-db.org/network/9606.ENSP00000286808Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tub [...]
TIAM1 protein networkhttps://string-db.org/network/9606.ENSP00000286827T-lymphoma invasion and metastasis-inducing protein 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimu [...]
SCAF4 protein networkhttps://string-db.org/network/9606.ENSP00000286835SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alterna [...]
ANKRD9 protein networkhttps://string-db.org/network/9606.ENSP00000286918Ankyrin repeat domain 9.
FUT6 protein networkhttps://string-db.org/network/9606.ENSP00000286955Alpha-(1,3)-fucosyltransferase 6; Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated subst [...]
PCDH1 protein networkhttps://string-db.org/network/9606.ENSP00000287008Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion.
GDF6 protein networkhttps://string-db.org/network/9606.ENSP00000287020Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal d [...]
MTERF3 protein networkhttps://string-db.org/network/9606.ENSP00000287025Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal as [...]
KCNS2 protein networkhttps://string-db.org/network/9606.ENSP00000287042Potassium voltage-gated channel subfamily S member 2; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB [...]
TYSND1 protein networkhttps://string-db.org/network/9606.ENSP00000287078Peroxisomal leader peptide-processing protease, 15 kDa form; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processe [...]
CD109 protein networkhttps://string-db.org/network/9606.ENSP00000287097CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.
NODAL protein networkhttps://string-db.org/network/9606.ENSP00000287139Nodal homolog; Essential for mesoderm formation and axial patterning during embryonic development; Belongs to the TGF-beta family.
PRG3 protein networkhttps://string-db.org/network/9606.ENSP00000287143Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 rel [...]
KIF6 protein networkhttps://string-db.org/network/9606.ENSP00000287152Kinesin-like protein KIF6; Kinesin family member 6.
UBE2L6 protein networkhttps://string-db.org/network/9606.ENSP00000287156Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquit [...]
ZDHHC5 protein networkhttps://string-db.org/network/9606.ENSP00000287169Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity).
CELF6 protein networkhttps://string-db.org/network/9606.ENSP00000287202CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissu [...]
ZFAND3 protein networkhttps://string-db.org/network/9606.ENSP00000287218Zinc finger AN1-type containing 3.
KAT6B protein networkhttps://string-db.org/network/9606.ENSP00000287239Histone acetyltransferase KAT6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2- dependent transcriptional activatio [...]
GLYATL2 protein networkhttps://string-db.org/network/9606.ENSP00000287275Glycine N-acyltransferase-like protein 2; Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and s [...]
AIFM1 protein networkhttps://string-db.org/network/9606.ENSP00000287295Apoptosis-inducing factor 1, mitochondrial; Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembr [...]
BAG4 protein networkhttps://string-db.org/network/9606.ENSP00000287322BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regul [...]
TBC1D31 protein networkhttps://string-db.org/network/9606.ENSP00000287380TBC1 domain family member 31.
WDYHV1 protein networkhttps://string-db.org/network/9606.ENSP00000287387Protein N-terminal glutamine amidohydrolase; Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Con [...]
ATAD2 protein networkhttps://string-db.org/network/9606.ENSP00000287394ATPase family AAA domain-containing protein 2; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as C [...]
NSMCE2 protein networkhttps://string-db.org/network/9606.ENSP00000287437E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for th [...]
ZNF689 protein networkhttps://string-db.org/network/9606.ENSP00000287461Zinc finger protein 689; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FRRS1 protein networkhttps://string-db.org/network/9606.ENSP00000287474Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family.
SASS6 protein networkhttps://string-db.org/network/9606.ENSP00000287482Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for [...]
COX6A2 protein networkhttps://string-db.org/network/9606.ENSP00000287490Cytochrome c oxidase subunit 6A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The r [...]
ZIC3 protein networkhttps://string-db.org/network/9606.ENSP00000287538Zinc finger protein ZIC 3; Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal G [...]
LHFPL4 protein networkhttps://string-db.org/network/9606.ENSP00000287585LHFPL tetraspan subfamily member 4 protein; Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma- aminobutyric acid receptors (GABAARs [...]
B3GNT7 protein networkhttps://string-db.org/network/9606.ENSP00000287590UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a [...]
BUB1B protein networkhttps://string-db.org/network/9606.ENSP00000287598Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until [...]
PDE6D protein networkhttps://string-db.org/network/9606.ENSP00000287600Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated [...]
SST protein networkhttps://string-db.org/network/9606.ENSP00000287641Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs gh [...]
FANCD2 protein networkhttps://string-db.org/network/9606.ENSP00000287647Fanconi anemia group D2 protein; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand [...]
TATDN2 protein networkhttps://string-db.org/network/9606.ENSP00000287652Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease.
NOMO1 protein networkhttps://string-db.org/network/9606.ENSP00000287667Nodal modulator 1; May antagonize Nodal signaling.
EXOG protein networkhttps://string-db.org/network/9606.ENSP00000287675Nuclease EXOG, mitochondrial; Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
NTAN1 protein networkhttps://string-db.org/network/9606.ENSP00000287706Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnov [...]
NMNAT2 protein networkhttps://string-db.org/network/9606.ENSP00000287713Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the for [...]
ZFYVE9 protein networkhttps://string-db.org/network/9606.ENSP00000287727Zinc finger FYVE domain-containing protein 9; Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TG [...]
LYZL4 protein networkhttps://string-db.org/network/9606.ENSP00000287748Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 f [...]
KLHL40 protein networkhttps://string-db.org/network/9606.ENSP00000287777Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by [...]
TIMP4 protein networkhttps://string-db.org/network/9606.ENSP00000287814Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2 [...]
PPARG protein networkhttps://string-db.org/network/9606.ENSP00000287820Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear recepto [...]
NRG1 protein networkhttps://string-db.org/network/9606.ENSP00000287842Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine [...]
ABCF2-2 protein networkhttps://string-db.org/network/9606.ENSP00000287844ATP binding cassette subfamily F member 2.
ODR4 protein networkhttps://string-db.org/network/9606.ENSP00000287859Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family.
PRKAG2 protein networkhttps://string-db.org/network/9606.ENSP000002878785'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...]
HTR5A protein networkhttps://string-db.org/network/9606.ENSP000002879075-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
CLDN12 protein networkhttps://string-db.org/network/9606.ENSP00000287916Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
FZD1 protein networkhttps://string-db.org/network/9606.ENSP00000287934Frizzled-1; Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing ac [...]
HMGCR protein networkhttps://string-db.org/network/9606.ENSP000002879363-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids th [...]
GATAD1 protein networkhttps://string-db.org/network/9606.ENSP00000287957GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form [...]
IPPK protein networkhttps://string-db.org/network/9606.ENSP00000287996Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homo [...]
THTPA protein networkhttps://string-db.org/network/9606.ENSP00000288014Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family.
PDF protein networkhttps://string-db.org/network/9606.ENSP00000288022Peptide deformylase, mitochondrial; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family.
TMED6 protein networkhttps://string-db.org/network/9606.ENSP00000288025Transmembrane p24 trafficking protein 6.
PDPR protein networkhttps://string-db.org/network/9606.ENSP00000288050Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine; Belongs to th [...]
ARMC12 protein networkhttps://string-db.org/network/9606.ENSP00000288065Armadillo repeat containing 12.
FCSK protein networkhttps://string-db.org/network/9606.ENSP00000288078L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.
MDP1 protein networkhttps://string-db.org/network/9606.ENSP00000288087Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.
KIT protein networkhttps://string-db.org/network/9606.ENSP00000288135Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and [...]
CACNA1D protein networkhttps://string-db.org/network/9606.ENSP00000288139Voltage-dependent L-type calcium channel subunit alpha-1D; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...]
IL17RB protein networkhttps://string-db.org/network/9606.ENSP00000288167Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
ZNF19 protein networkhttps://string-db.org/network/9606.ENSP00000288177Zinc finger protein 19; May be involved in transcriptional regulation.
CCNB2 protein networkhttps://string-db.org/network/9606.ENSP00000288207G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily.
ERC2 protein networkhttps://string-db.org/network/9606.ENSP00000288221ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May [...]
FAM81A protein networkhttps://string-db.org/network/9606.ENSP00000288228Protein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family.
MYO1E protein networkhttps://string-db.org/network/9606.ENSP00000288235Unconventional myosin-Ie; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous co [...]
APPL1 protein networkhttps://string-db.org/network/9606.ENSP00000288266DCC-interacting protein 13-alpha; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell prolife [...]
PREX2 protein networkhttps://string-db.org/network/9606.ENSP00000288368Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free [...]
C9orf43 protein networkhttps://string-db.org/network/9606.ENSP00000288462Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43.
DGKI protein networkhttps://string-db.org/network/9606.ENSP00000288490Diacylglycerol kinase iota.
COQ5 protein networkhttps://string-db.org/network/9606.ENSP000002885322-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-meth [...]
PSMG3 protein networkhttps://string-db.org/network/9606.ENSP00000288607Proteasome assembly chaperone 3; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes; B [...]
FMNL2 protein networkhttps://string-db.org/network/9606.ENSP00000288670Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family.
SPPL3 protein networkhttps://string-db.org/network/9606.ENSP00000288680Signal peptide peptidase-like 3; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. A [...]
DPYSL5 protein networkhttps://string-db.org/network/9606.ENSP00000288699Dihydropyrimidinase-related protein 5; May have a function in neuronal differentiation and/or axon growth; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinas [...]
DRC1 protein networkhttps://string-db.org/network/9606.ENSP00000288710Dynein regulatory complex protein 1; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dist [...]
PEX10 protein networkhttps://string-db.org/network/9606.ENSP00000288774Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes.
WIPI2 protein networkhttps://string-db.org/network/9606.ENSP00000288828WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged [...]
SMAD6 protein networkhttps://string-db.org/network/9606.ENSP00000288840Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-ka [...]
CIB4 protein networkhttps://string-db.org/network/9606.ENSP00000288861Calcium and integrin binding family member 4.
WDR66 protein networkhttps://string-db.org/network/9606.ENSP00000288912Cilia- and flagella-associated protein 251; Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).
MRPL17 protein networkhttps://string-db.org/network/9606.ENSP00000288937Mitochondrial ribosomal protein L17.
DUSP2 protein networkhttps://string-db.org/network/9606.ENSP00000288943Dual specificity protein phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
GRHL3 protein networkhttps://string-db.org/network/9606.ENSP00000288955Grainyhead-like protein 3 homolog; Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin [...]
HPD protein networkhttps://string-db.org/network/9606.ENSP000002890044-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.
RHPN1 protein networkhttps://string-db.org/network/9606.ENSP00000289013Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules; Belongs to the RHPN [...]
FANCC protein networkhttps://string-db.org/network/9606.ENSP00000289081Fanconi anemia group C protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...]
MRAS protein networkhttps://string-db.org/network/9606.ENSP00000289104Ras-related protein M-Ras; Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
ABHD3 protein networkhttps://string-db.org/network/9606.ENSP00000289119Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 [...]
TENT5B protein networkhttps://string-db.org/network/9606.ENSP00000289166Terminal nucleotidyltransferase 5B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the TENT family.
ACTR1B protein networkhttps://string-db.org/network/9606.ENSP00000289228Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
RHBDL2 protein networkhttps://string-db.org/network/9606.ENSP00000289248Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate [...]
PCDHAC2 protein networkhttps://string-db.org/network/9606.ENSP00000289269Protocadherin alpha-C2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHA13 protein networkhttps://string-db.org/network/9606.ENSP00000289272Protocadherin alpha-13; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
H2BC5 protein networkhttps://string-db.org/network/9606.ENSP00000289316Histone H2B type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
MITD1 protein networkhttps://string-db.org/network/9606.ENSP00000289359MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.
BTN3A1 protein networkhttps://string-db.org/network/9606.ENSP00000289361Butyrophilin subfamily 3 member A1; Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and [...]
EIF5B protein networkhttps://string-db.org/network/9606.ENSP00000289371Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex [...]
TMSB15A protein networkhttps://string-db.org/network/9606.ENSP00000289373Thymosin beta-15A; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); B [...]
CNOT11 protein networkhttps://string-db.org/network/9606.ENSP00000289382CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA d [...]
CATIP protein networkhttps://string-db.org/network/9606.ENSP00000289388Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization.
ACSM3 protein networkhttps://string-db.org/network/9606.ENSP00000289416Acyl-coenzyme A synthetase ACSM3, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activat [...]
CD1A protein networkhttps://string-db.org/network/9606.ENSP00000289429T-cell surface glycoprotein CD1a; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
HMHB1 protein networkhttps://string-db.org/network/9606.ENSP00000289448Minor histocompatibility antigen HB-1; Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when compl [...]
NCF1 protein networkhttps://string-db.org/network/9606.ENSP00000289473Neutrophil cytosol factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
ZFAND2B protein networkhttps://string-db.org/network/9606.ENSP00000289528AN1-type zinc finger protein 2B; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic [...]
NPC1L1 protein networkhttps://string-db.org/network/9606.ENSP00000289547NPC1-like intracellular cholesterol transporter 1; Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte [...]
SLCO2B1 protein networkhttps://string-db.org/network/9606.ENSP00000289575Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, t [...]
PAGE5 protein networkhttps://string-db.org/network/9606.ENSP00000289619PAGE family member 5; Belongs to the GAGE family.
PKD1L1 protein networkhttps://string-db.org/network/9606.ENSP00000289672Polycystic kidney disease protein 1-like 1; Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Fo [...]
SLAMF8 protein networkhttps://string-db.org/network/9606.ENSP00000289707SLAM family member 8; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.
CDH15 protein networkhttps://string-db.org/network/9606.ENSP00000289746Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
NBL1 protein networkhttps://string-db.org/network/9606.ENSP00000289749Neuroblastoma suppressor of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) o [...]
HTR6 protein networkhttps://string-db.org/network/9606.ENSP000002897535-hydroxytryptamine receptor 6; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...]
ZSCAN23 protein networkhttps://string-db.org/network/9606.ENSP00000289788Zinc finger and SCAN domain-containing protein 23; May be involved in transcriptional regulation.
SPATA2L protein networkhttps://string-db.org/network/9606.ENSP00000289805Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like.
FCER1G protein networkhttps://string-db.org/network/9606.ENSP00000289902High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various im [...]
FAM160B2 protein networkhttps://string-db.org/network/9606.ENSP00000289921Protein FAM160B2; Family with sequence similarity 160 member B2; Belongs to the UPF0518 family.
SLC5A11 protein networkhttps://string-db.org/network/9606.ENSP00000289932Sodium/myo-inositol cotransporter 2; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and ab [...]
CHRNB3 protein networkhttps://string-db.org/network/9606.ENSP00000289957Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...]
ARHGAP17 protein networkhttps://string-db.org/network/9606.ENSP00000289968Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarit [...]
C8orf58 protein networkhttps://string-db.org/network/9606.ENSP00000289989Uncharacterized protein C8orf58; Chromosome 8 open reading frame 58.
WNT9B protein networkhttps://string-db.org/network/9606.ENSP00000290015Protein Wnt-9b; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic [...]
CACHD1 protein networkhttps://string-db.org/network/9606.ENSP00000290039VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels.
TMEM141 protein networkhttps://string-db.org/network/9606.ENSP00000290079Transmembrane protein 141.
CELA3A protein networkhttps://string-db.org/network/9606.ENSP00000290122Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily.
MIS18A protein networkhttps://string-db.org/network/9606.ENSP00000290130Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
CFAP298 protein networkhttps://string-db.org/network/9606.ENSP00000290155Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance o [...]
KPNB1 protein networkhttps://string-db.org/network/9606.ENSP00000290158Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in c [...]
WNT4 protein networkhttps://string-db.org/network/9606.ENSP00000290167Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Re [...]
IL10RB protein networkhttps://string-db.org/network/9606.ENSP00000290200Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor [...]
MRPL10 protein networkhttps://string-db.org/network/9606.ENSP00000290208Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family.
SCRN2 protein networkhttps://string-db.org/network/9606.ENSP00000290216Secernin-2; Secernin 2; Belongs to the peptidase C69 family. Secernin subfamily.
NCOA5 protein networkhttps://string-db.org/network/9606.ENSP00000290231Nuclear receptor coactivator 5; Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently [...]
ELMO2 protein networkhttps://string-db.org/network/9606.ENSP00000290246Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...]
STC1 protein networkhttps://string-db.org/network/9606.ENSP00000290271Stanniocalcin-1; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
ARAF protein networkhttps://string-db.org/network/9606.ENSP00000290277Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein [...]
OGFR protein networkhttps://string-db.org/network/9606.ENSP00000290291Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met- enkephalin. Seems to be involved in growth regulation.
PRAC1 protein networkhttps://string-db.org/network/9606.ENSP00000290294PRAC1 small nuclear protein.
HOXB13 protein networkhttps://string-db.org/network/9606.ENSP00000290295Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
ATP5PO protein networkhttps://string-db.org/network/9606.ENSP00000290299ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...]
KCNE2 protein networkhttps://string-db.org/network/9606.ENSP00000290310Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...]
IGF2BP1 protein networkhttps://string-db.org/network/9606.ENSP00000290341Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows m [...]
CBR1 protein networkhttps://string-db.org/network/9606.ENSP00000290349Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menad [...]
CBR3 protein networkhttps://string-db.org/network/9606.ENSP00000290354Carbonyl reductase [NADPH] 3; Has low NADPH-dependent oxidoreductase activity towards 4- benzoylpyridine and menadione (in vitro). Belongs to the short-chain dehydrogenases/reductases (SDR) famil [...]
CIART protein networkhttps://string-db.org/network/9606.ENSP00000290363Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptiona [...]
GJD2 protein networkhttps://string-db.org/network/9606.ENSP00000290374Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
ACTC1 protein networkhttps://string-db.org/network/9606.ENSP00000290378Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
SIM2 protein networkhttps://string-db.org/network/9606.ENSP00000290399Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
NPTN protein networkhttps://string-db.org/network/9606.ENSP00000290401Neuroplastin; Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate ne [...]
CCDC142 protein networkhttps://string-db.org/network/9606.ENSP00000290418Coiled-coil domain containing 142.
MCAT protein networkhttps://string-db.org/network/9606.ENSP00000290429Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondria [...]
GOLGA6A protein networkhttps://string-db.org/network/9606.ENSP00000290438Golgin A6 family member A.
PLA2G4D protein networkhttps://string-db.org/network/9606.ENSP00000290472Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position [...]
RFX5 protein networkhttps://string-db.org/network/9606.ENSP00000290524DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Bel [...]
M1AP protein networkhttps://string-db.org/network/9606.ENSP00000290536Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis.
PSMB4 protein networkhttps://string-db.org/network/9606.ENSP00000290541Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
BTG2 protein networkhttps://string-db.org/network/9606.ENSP00000290551Protein BTG2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent ma [...]
IRX6 protein networkhttps://string-db.org/network/9606.ENSP00000290552Iroquois-class homeodomain protein IRX-6; Iroquois homeobox 6.
HK2 protein networkhttps://string-db.org/network/9606.ENSP00000290573Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the init [...]
CELF3 protein networkhttps://string-db.org/network/9606.ENSP00000290583CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue- [...]
STARD9 protein networkhttps://string-db.org/network/9606.ENSP00000290607StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM).
AMFR protein networkhttps://string-db.org/network/9606.ENSP00000290649E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Compone [...]
UBR1 protein networkhttps://string-db.org/network/9606.ENSP00000290650E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are desta [...]
MED8 protein networkhttps://string-db.org/network/9606.ENSP00000290663Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
RGL4 protein networkhttps://string-db.org/network/9606.ENSP00000290691Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4.
MT1A protein networkhttps://string-db.org/network/9606.ENSP00000290705Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
PGLYRP3 protein networkhttps://string-db.org/network/9606.ENSP00000290722Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...]
ISL2 protein networkhttps://string-db.org/network/9606.ENSP00000290759Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
GSTT2B protein networkhttps://string-db.org/network/9606.ENSP00000290765Glutathione S-transferase theta-2B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.
CPNE2 protein networkhttps://string-db.org/network/9606.ENSP00000290776Copine-2; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium- dependent cell membrane binding properties. Belongs to th [...]
ACE protein networkhttps://string-db.org/network/9606.ENSP00000290866Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensi [...]
TEPP protein networkhttps://string-db.org/network/9606.ENSP00000290871Testis, prostate and placenta expressed.
KIAA0895L protein networkhttps://string-db.org/network/9606.ENSP00000290881Uncharacterized protein KIAA0895-like; KIAA0895 like.
SHF protein networkhttps://string-db.org/network/9606.ENSP00000290894SH2 domain-containing adapter protein F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF.
CHCHD6 protein networkhttps://string-db.org/network/9606.ENSP00000290913MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
CTBP1 protein networkhttps://string-db.org/network/9606.ENSP00000290921C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and [...]
ANKRD18B protein networkhttps://string-db.org/network/9606.ENSP00000290943Ankyrin repeat domain 18B.
ATP6V0D1 protein networkhttps://string-db.org/network/9606.ENSP00000290949V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryot [...]
AGRP protein networkhttps://string-db.org/network/9606.ENSP00000290953Agouti-related protein; Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antag [...]
ZFYVE28 protein networkhttps://string-db.org/network/9606.ENSP00000290974Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Be [...]
PIP protein networkhttps://string-db.org/network/9606.ENSP00000291009Prolactin induced protein; Belongs to the PIP family.
PSKH1 protein networkhttps://string-db.org/network/9606.ENSP00000291041Serine/threonine-protein kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors [...]
ZNF235 protein networkhttps://string-db.org/network/9606.ENSP00000291182Zinc finger protein 235; May be involved in transcriptional regulation.
OR3A3 protein networkhttps://string-db.org/network/9606.ENSP00000291231Olfactory receptor 3A3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TNFRSF13C protein networkhttps://string-db.org/network/9606.ENSP00000291232Tumor necrosis factor receptor superfamily member 13C; B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
PTGIR protein networkhttps://string-db.org/network/9606.ENSP00000291294Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
CALM3 protein networkhttps://string-db.org/network/9606.ENSP00000291295Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodul [...]
SSU72 protein networkhttps://string-db.org/network/9606.ENSP00000291386RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA proces [...]
TRIM62 protein networkhttps://string-db.org/network/9606.ENSP00000291416E3 ubiquitin-protein ligase TRIM62; E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2; Belongs to the TRIM/RBCC family.
NR2F6 protein networkhttps://string-db.org/network/9606.ENSP00000291442Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5 [...]
CCDC58 protein networkhttps://string-db.org/network/9606.ENSP00000291458Coiled-coil domain containing 58; Belongs to the CCDC58 family.
HAPLN4 protein networkhttps://string-db.org/network/9606.ENSP00000291481Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix.
CILP2 protein networkhttps://string-db.org/network/9606.ENSP00000291495Cartilage intermediate layer protein 2 C1; May play a role in cartilage scaffolding.
TFF2 protein networkhttps://string-db.org/network/9606.ENSP00000291526Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel [...]
TFF1 protein networkhttps://string-db.org/network/9606.ENSP00000291527Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate cry [...]
RSPH1 protein networkhttps://string-db.org/network/9606.ENSP00000291536Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes.
PDE9A protein networkhttps://string-db.org/network/9606.ENSP00000291539High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specif [...]
PKNOX1 protein networkhttps://string-db.org/network/9606.ENSP00000291547Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1.
U2AF1 protein networkhttps://string-db.org/network/9606.ENSP00000291552Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required fo [...]
CRYAA protein networkhttps://string-db.org/network/9606.ENSP00000291554Alpha-crystallin A2(1-162); Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress [...]
HSF2BP protein networkhttps://string-db.org/network/9606.ENSP00000291560Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cyt [...]
PDXK protein networkhttps://string-db.org/network/9606.ENSP00000291565Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family.
CSTB protein networkhttps://string-db.org/network/9606.ENSP00000291568Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family.
AGPAT3 protein networkhttps://string-db.org/network/9606.ENSP000002915721-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by i [...]
TRAPPC10 protein networkhttps://string-db.org/network/9606.ENSP00000291574Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TMEM1 family.
PWP2 protein networkhttps://string-db.org/network/9606.ENSP00000291576Periodic tryptophan protein 2 homolog; PWP2 small subunit processome component.
GATD3A protein networkhttps://string-db.org/network/9606.ENSP00000291577Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial; Glutamine amidotransferase like class 1 domain containing 3A; Belongs to the GATD3 family.
AIRE protein networkhttps://string-db.org/network/9606.ENSP00000291582Autoimmune regulator; Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonalit [...]
LRRC3 protein networkhttps://string-db.org/network/9606.ENSP00000291592Leucine-rich repeat-containing protein 3; Leucine rich repeat containing 3.
FAM207A protein networkhttps://string-db.org/network/9606.ENSP00000291634Protein FAM207A; Family with sequence similarity 207 member A.
SPATC1L protein networkhttps://string-db.org/network/9606.ENSP00000291672Speriolin-like protein; Spermatogenesis and centriole associated 1 like.
MCM3AP protein networkhttps://string-db.org/network/9606.ENSP00000291688Germinal-center associated nuclear protein; [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylati [...]
C21orf58 protein networkhttps://string-db.org/network/9606.ENSP00000291691Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58.
S100B protein networkhttps://string-db.org/network/9606.ENSP00000291700Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium io [...]
SIGLEC12 protein networkhttps://string-db.org/network/9606.ENSP00000291707Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sia [...]
CLDND2 protein networkhttps://string-db.org/network/9606.ENSP00000291715Claudin domain containing 2.
FCN2 protein networkhttps://string-db.org/network/9606.ENSP00000291744Ficolin-2; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, [...]
LILRA4 protein networkhttps://string-db.org/network/9606.ENSP00000291759Leukocyte immunoglobulin-like receptor subfamily A member 4; Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the product [...]
HIPK4 protein networkhttps://string-db.org/network/9606.ENSP00000291823Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of t [...]
SHKBP1 protein networkhttps://string-db.org/network/9606.ENSP00000291842SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits [...]
KIR3DL3 protein networkhttps://string-db.org/network/9606.ENSP00000291860Killer cell immunoglobulin-like receptor 3DL3; Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
NCR1 protein networkhttps://string-db.org/network/9606.ENSP00000291890Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
ZER1 protein networkhttps://string-db.org/network/9606.ENSP00000291900Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine d [...]
PKN3 protein networkhttps://string-db.org/network/9606.ENSP00000291906Serine/threonine-protein kinase N3; Contributes to invasiveness in malignant prostate cancer.
TMEM190 protein networkhttps://string-db.org/network/9606.ENSP00000291934Transmembrane protein 190.
NLRP8 protein networkhttps://string-db.org/network/9606.ENSP00000291971NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation.
MED27 protein networkhttps://string-db.org/network/9606.ENSP00000292035Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
FXYD2 protein networkhttps://string-db.org/network/9606.ENSP00000292079Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase; Belongs [...]
TLCD1 protein networkhttps://string-db.org/network/9606.ENSP00000292090TLC domain-containing protein 1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyu [...]
TMEM199 protein networkhttps://string-db.org/network/9606.ENSP00000292114Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intrace [...]
PSG6 protein networkhttps://string-db.org/network/9606.ENSP00000292125Pregnancy specific beta-1-glycoprotein 6.
PHLDB3 protein networkhttps://string-db.org/network/9606.ENSP00000292140Pleckstrin homology like domain family B member 3.
ETHE1 protein networkhttps://string-db.org/network/9606.ENSP00000292147Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized [...]
S100A1 protein networkhttps://string-db.org/network/9606.ENSP00000292169Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational [...]
CXCR5 protein networkhttps://string-db.org/network/9606.ENSP00000292174C-X-C chemokine receptor type 5; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into th [...]
FLAD1 protein networkhttps://string-db.org/network/9606.ENSP00000292180Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belon [...]
UBE2Q1 protein networkhttps://string-db.org/network/9606.ENSP00000292211Ubiquitin-conjugating enzyme E2 Q1; Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell su [...]
ANO10 protein networkhttps://string-db.org/network/9606.ENSP00000292246Anoctamin-10; Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. Belongs to the anoctamin family.
CCR2 protein networkhttps://string-db.org/network/9606.ENSP00000292301C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction th [...]
CCR5 protein networkhttps://string-db.org/network/9606.ENSP00000292303C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the in [...]
CCDC12 protein networkhttps://string-db.org/network/9606.ENSP00000292314Coiled-coil domain containing 12.
PPP1R35 protein networkhttps://string-db.org/network/9606.ENSP00000292330Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity. Belongs to the PPP1R35 family.
RNF126 protein networkhttps://string-db.org/network/9606.ENSP00000292363E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'- linked pol [...]
GPC2 protein networkhttps://string-db.org/network/9606.ENSP00000292377Secreted glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Belongs to the glypican fa [...]
AZGP1 protein networkhttps://string-db.org/network/9606.ENSP00000292401Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to t [...]
FGFR4 protein networkhttps://string-db.org/network/9606.ENSP00000292408Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentia [...]
CYP11B1 protein networkhttps://string-db.org/network/9606.ENSP00000292427Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of [...]
LY6K protein networkhttps://string-db.org/network/9606.ENSP00000292430Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth.
NACC1 protein networkhttps://string-db.org/network/9606.ENSP00000292431Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Cont [...]
HK3 protein networkhttps://string-db.org/network/9606.ENSP00000292432Hexokinase-3; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the init [...]
ZSCAN21 protein networkhttps://string-db.org/network/9606.ENSP00000292450Zinc finger and SCAN domain-containing protein 21; Strong transcriptional activator.
ATP5MF protein networkhttps://string-db.org/network/9606.ENSP00000292475ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...]
CPSF4 protein networkhttps://string-db.org/network/9606.ENSP00000292476Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...]
PTCD1 protein networkhttps://string-db.org/network/9606.ENSP00000292478Pentatricopeptide repeat-containing protein 1, mitochondrial; Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria- encod [...]
PTGER1 protein networkhttps://string-db.org/network/9606.ENSP00000292513Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messen [...]
LRRC14 protein networkhttps://string-db.org/network/9606.ENSP00000292524Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs t [...]
ZNF333 protein networkhttps://string-db.org/network/9606.ENSP00000292530Zinc finger protein 333; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PPP1R16A protein networkhttps://string-db.org/network/9606.ENSP00000292539Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.
ZNF251 protein networkhttps://string-db.org/network/9606.ENSP00000292562Zinc finger protein 251; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ALKBH4 protein networkhttps://string-db.org/network/9606.ENSP00000292566Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-process [...]
CCDC105 protein networkhttps://string-db.org/network/9606.ENSP00000292574Coiled-coil domain containing 105.
ZNF250 protein networkhttps://string-db.org/network/9606.ENSP00000292579Zinc finger protein 250; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MRNIP protein networkhttps://string-db.org/network/9606.ENSP00000292586MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes [...]
LTC4S protein networkhttps://string-db.org/network/9606.ENSP00000292596Leukotriene C4 synthase; Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
MAML1 protein networkhttps://string-db.org/network/9606.ENSP00000292599Mastermind-like protein 1; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnov [...]
PGLYRP2 protein networkhttps://string-db.org/network/9606.ENSP00000292609N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity; Belo [...]
POLR2J protein networkhttps://string-db.org/network/9606.ENSP00000292614DNA-directed RNA polymerase II subunit RPB11-a; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RN [...]
LRWD1 protein networkhttps://string-db.org/network/9606.ENSP00000292616Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replic [...]
SCGB3A1 protein networkhttps://string-db.org/network/9606.ENSP00000292641Secretoglobin family 3A member 1; Secreted cytokine-like protein. Inhibits cell growth in vitro; Belongs to the secretoglobin family. UGRP subfamily.
CELF5 protein networkhttps://string-db.org/network/9606.ENSP00000292672CUGBP Elav-like family member 5; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissu [...]
YDJC protein networkhttps://string-db.org/network/9606.ENSP00000292778Carbohydrate deacetylase; Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. Belongs to the YdjC deacetylase family.
CCDC116 protein networkhttps://string-db.org/network/9606.ENSP00000292779Coiled-coil domain containing 116.
DCUN1D1 protein networkhttps://string-db.org/network/9606.ENSP00000292782DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 [...]
PCYT1A protein networkhttps://string-db.org/network/9606.ENSP00000292823Choline-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family.
ZNF585A protein networkhttps://string-db.org/network/9606.ENSP00000292841Zinc finger protein 585A; May be involved in transcriptional regulation.
FBXO17 protein networkhttps://string-db.org/network/9606.ENSP00000292852F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modifie [...]
FBXO27 protein networkhttps://string-db.org/network/9606.ENSP00000292853F-box only protein 27; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modifie [...]
U2AF1L4 protein networkhttps://string-db.org/network/9606.ENSP00000292879C3H1-type domain-containing protein; U2 small nuclear RNA auxiliary factor 1 like 4.
THAP8 protein networkhttps://string-db.org/network/9606.ENSP00000292894THAP domain containing 8.
HBE1 protein networkhttps://string-db.org/network/9606.ENSP00000292896Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family.
COX7A1 protein networkhttps://string-db.org/network/9606.ENSP00000292907Cytochrome c oxidase subunit 7A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The r [...]
ZNF382 protein networkhttps://string-db.org/network/9606.ENSP00000292928Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family.
GRIN2C protein networkhttps://string-db.org/network/9606.ENSP00000293190Glutamate receptor ionotropic, NMDA 2C; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...]
ACOX1 protein networkhttps://string-db.org/network/9606.ENSP00000293217Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decrease [...]
CYGB protein networkhttps://string-db.org/network/9606.ENSP00000293230Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.
CABP5 protein networkhttps://string-db.org/network/9606.ENSP00000293255Calcium-binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials (By similarity). I [...]
TMEM143 protein networkhttps://string-db.org/network/9606.ENSP00000293261Transmembrane protein 143.
BAX protein networkhttps://string-db.org/network/9606.ENSP00000293288Apoptosis regulator BAX; Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol me [...]
KLHL10 protein networkhttps://string-db.org/network/9606.ENSP00000293303Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target p [...]
STAT5B protein networkhttps://string-db.org/network/9606.ENSP00000293328Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and ot [...]
HCRT protein networkhttps://string-db.org/network/9606.ENSP00000293330Orexin-A; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these com [...]
ALDH16A1 protein networkhttps://string-db.org/network/9606.ENSP00000293350Aldehyde dehydrogenase 16 family member A1.
PSME3 protein networkhttps://string-db.org/network/9606.ENSP00000293362Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-ga [...]
NCKAP1L protein networkhttps://string-db.org/network/9606.ENSP00000293373Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythro [...]
ITGA5 protein networkhttps://string-db.org/network/9606.ENSP00000293379Integrin alpha-5 heavy chain; Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via [...]
NAGS protein networkhttps://string-db.org/network/9606.ENSP00000293404N-acetylglutamate synthase conserved domain form; Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate syn [...]
IZUMO2 protein networkhttps://string-db.org/network/9606.ENSP00000293405Izumo sperm-egg fusion protein 2; IZUMO family member 2.
ASB16 protein networkhttps://string-db.org/network/9606.ENSP00000293414Ankyrin repeat and SOCS box protein 16; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
SHANK1 protein networkhttps://string-db.org/network/9606.ENSP00000293441SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membran [...]
FAM171A2 protein networkhttps://string-db.org/network/9606.ENSP00000293443Protein FAM171A2; Family with sequence similarity 171 member A2.
ZNF613 protein networkhttps://string-db.org/network/9606.ENSP00000293471Zinc finger protein 613; May be involved in transcriptional regulation.
SDR9C7 protein networkhttps://string-db.org/network/9606.ENSP00000293502Short-chain dehydrogenase/reductase family 9C member 7; Displays weak conversion of all-trans-retinal to all-trans- retinol in the presence of NADH. Has apparently no steroid dehydrogenase activi [...]
WNT1 protein networkhttps://string-db.org/network/9606.ENSP00000293549Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transc [...]
AQP5 protein networkhttps://string-db.org/network/9606.ENSP00000293599Aquaporin-5; Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, con [...]
C6orf136 protein networkhttps://string-db.org/network/9606.ENSP00000293604Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136.
CELA1 protein networkhttps://string-db.org/network/9606.ENSP00000293636Chymotrypsin-like elastase family member 1; Acts upon elastin.
GRASP protein networkhttps://string-db.org/network/9606.ENSP00000293662General receptor for phosphoinositides 1-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamat [...]
KRT83 protein networkhttps://string-db.org/network/9606.ENSP00000293670Keratin, type II cuticular Hb3; Keratin 83; Belongs to the intermediate filament family.
SYCE2 protein networkhttps://string-db.org/network/9606.ENSP00000293695Synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...]
ZNF563 protein networkhttps://string-db.org/network/9606.ENSP00000293725Zinc finger protein 563; May be involved in transcriptional regulation.
KRT72 protein networkhttps://string-db.org/network/9606.ENSP00000293745Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
IP6K3 protein networkhttps://string-db.org/network/9606.ENSP00000293756Inositol hexakisphosphate kinase 3; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. B [...]
LEMD2 protein networkhttps://string-db.org/network/9606.ENSP00000293760LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope.
ALOX15 protein networkhttps://string-db.org/network/9606.ENSP00000293761Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioa [...]
ZNF653 protein networkhttps://string-db.org/network/9606.ENSP00000293771Zinc finger protein 653; Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity. Belongs to the krueppel C2H2-type zinc-finger protein family.
MED11 protein networkhttps://string-db.org/network/9606.ENSP00000293777Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
CXCL16 protein networkhttps://string-db.org/network/9606.ENSP00000293778C-X-C motif chemokine 16; Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology [...]
BCL6B protein networkhttps://string-db.org/network/9606.ENSP00000293805B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B- [...]
TNFSF12 protein networkhttps://string-db.org/network/9606.ENSP00000293825Tumor necrosis factor ligand superfamily member 12, membrane form; Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. [...]
ENSP00000293826 protein networkhttps://string-db.org/network/9606.ENSP00000293826TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family.
FGF11 protein networkhttps://string-db.org/network/9606.ENSP00000293829Fibroblast growth factor 11; Probably involved in nervous system development and function; Belongs to the heparin-binding growth factors family.
EIF4A1 protein networkhttps://string-db.org/network/9606.ENSP00000293831Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current mode [...]
CCDC42 protein networkhttps://string-db.org/network/9606.ENSP00000293845Coiled-coil domain-containing protein 42; Required for sperm development.
PRSS33 protein networkhttps://string-db.org/network/9606.ENSP00000293851Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues.
POLR3K protein networkhttps://string-db.org/network/9606.ENSP00000293860DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA [...]
LUC7L protein networkhttps://string-db.org/network/9606.ENSP00000293872Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain.
WDR90 protein networkhttps://string-db.org/network/9606.ENSP00000293879WD repeat-containing protein 90; Required for efficient primary cilium formation.
WDR24 protein networkhttps://string-db.org/network/9606.ENSP00000293883GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC [...]
CCDC78 protein networkhttps://string-db.org/network/9606.ENSP00000293889Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles [...]
SOX8 protein networkhttps://string-db.org/network/9606.ENSP00000293894Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By [...]
SSTR5 protein networkhttps://string-db.org/network/9606.ENSP00000293897Somatostatin receptor type 5; Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Incr [...]
NTN3 protein networkhttps://string-db.org/network/9606.ENSP00000293973Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons.
SLX4 protein networkhttps://string-db.org/network/9606.ENSP00000294008Structure-specific endonuclease subunit SLX4; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protec [...]
ADCY9 protein networkhttps://string-db.org/network/9606.ENSP00000294016Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades [...]
CLPB protein networkhttps://string-db.org/network/9606.ENSP00000294053Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process.
NEU3 protein networkhttps://string-db.org/network/9606.ENSP00000294064Sialidase-3; Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. Belongs to the glycosyl hydrolase 33 family.
MAP4K2 protein networkhttps://string-db.org/network/9606.ENSP00000294066Mitogen-activated protein kinase kinase kinase kinase 2; Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase [...]
GNG3 protein networkhttps://string-db.org/network/9606.ENSP00000294117Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
UBXN1 protein networkhttps://string-db.org/network/9606.ENSP00000294119UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Follo [...]
NCKIPSD protein networkhttps://string-db.org/network/9606.ENSP00000294129NCK-interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarit [...]
TAF6L protein networkhttps://string-db.org/network/9606.ENSP00000294168TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating hi [...]
STX5 protein networkhttps://string-db.org/network/9606.ENSP00000294179Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked [...]
RPL29 protein networkhttps://string-db.org/network/9606.ENSP0000029418960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family.
SPINDOC protein networkhttps://string-db.org/network/9606.ENSP00000294244Spindlin interactor and repressor of chromatin-binding protein; Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represse [...]
ZFPL1 protein networkhttps://string-db.org/network/9606.ENSP00000294258Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis- Golgi, possibly via its interaction with [...]
CABP2 protein networkhttps://string-db.org/network/9606.ENSP00000294288Calcium-binding protein 2; Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the [...]
LRP5 protein networkhttps://string-db.org/network/9606.ENSP00000294304Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activat [...]
TPCN2 protein networkhttps://string-db.org/network/9606.ENSP00000294309Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal [...]
FGF19 protein networkhttps://string-db.org/network/9606.ENSP00000294312Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stim [...]
PDZK1IP1 protein networkhttps://string-db.org/network/9606.ENSP00000294338PDZK1-interacting protein 1; May play an important role in tumor biology.
TAL1 protein networkhttps://string-db.org/network/9606.ENSP00000294339T-cell acute lymphocytic leukemia protein 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of [...]
ZYG11B protein networkhttps://string-db.org/network/9606.ENSP00000294353Protein zyg-11 homolog B; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine [...]
CZIB protein networkhttps://string-db.org/network/9606.ENSP00000294360CXXC motif containing zinc binding protein; Belongs to the UPF0587 family.
USP24 protein networkhttps://string-db.org/network/9606.ENSP00000294383Ubiquitin carboxyl-terminal hydrolase 24; Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including [...]
GMEB1 protein networkhttps://string-db.org/network/9606.ENSP00000294409Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increas [...]
RHCE protein networkhttps://string-db.org/network/9606.ENSP00000294413Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Belongs to the ammonium transporter (TC 2 [...]
RBP7 protein networkhttps://string-db.org/network/9606.ENSP00000294435Retinoid-binding protein 7; Intracellular transport of retinol.
SLC25A34 protein networkhttps://string-db.org/network/9606.ENSP00000294454Solute carrier family 25 member 34.
DISP3 protein networkhttps://string-db.org/network/9606.ENSP00000294484Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid [...]
DRAXIN protein networkhttps://string-db.org/network/9606.ENSP00000294485Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during developm [...]
PDPN protein networkhttps://string-db.org/network/9606.ENSP0000029448929kDa cytosolic podoplanin intracellular domain; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels sep [...]
LAPTM5 protein networkhttps://string-db.org/network/9606.ENSP00000294507Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family.
TMCO4 protein networkhttps://string-db.org/network/9606.ENSP00000294543Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family.
CCDC27 protein networkhttps://string-db.org/network/9606.ENSP00000294600Coiled-coil domain containing 27.
DOCK6 protein networkhttps://string-db.org/network/9606.ENSP00000294618Dedicator of cytokinesis protein 6; Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By [...]
LRRC53 protein networkhttps://string-db.org/network/9606.ENSP00000294635Leucine-rich repeat-containing protein 53; Leucine rich repeat containing 53.
LHX8 protein networkhttps://string-db.org/network/9606.ENSP00000294638LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
WDR63 protein networkhttps://string-db.org/network/9606.ENSP00000294664WD repeat-containing protein 63.
GBP7 protein networkhttps://string-db.org/network/9606.ENSP00000294671Guanylate-binding protein 7; Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad hos [...]
GFI1 protein networkhttps://string-db.org/network/9606.ENSP00000294702Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region [...]
AGL protein networkhttps://string-db.org/network/9606.ENSP00000294724Amylo-alpha-1,6-glucosidase; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
KCNT2 protein networkhttps://string-db.org/network/9606.ENSP00000294725Potassium channel subfamily T member 2; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride leve [...]
VCAM1 protein networkhttps://string-db.org/network/9606.ENSP00000294728Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocyt [...]
ZNF281 protein networkhttps://string-db.org/network/9606.ENSP00000294740Zinc finger protein 281; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepres [...]
ARPC5 protein networkhttps://string-db.org/network/9606.ENSP00000294742Actin-related protein 2/3 complex subunit 5; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The [...]
ZNF496 protein networkhttps://string-db.org/network/9606.ENSP00000294753Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family.
NCSTN protein networkhttps://string-db.org/network/9606.ENSP00000294785Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amylo [...]
C1orf74 protein networkhttps://string-db.org/network/9606.ENSP00000294811UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family.
LRRC52 protein networkhttps://string-db.org/network/9606.ENSP00000294818Leucine-rich repeat-containing protein 52; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...]
FAM71A protein networkhttps://string-db.org/network/9606.ENSP00000294829Protein FAM71A; Family with sequence similarity 71 member A; Belongs to the FAM71 family.
C1orf115 protein networkhttps://string-db.org/network/9606.ENSP00000294889Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115.
RBMS1 protein networkhttps://string-db.org/network/9606.ENSP00000294904RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif [...]
PPP1R21 protein networkhttps://string-db.org/network/9606.ENSP00000294952Protein phosphatase 1 regulatory subunit 21; Putative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.
LHCGR protein networkhttps://string-db.org/network/9606.ENSP00000294954Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
PKDCC protein networkhttps://string-db.org/network/9606.ENSP00000294964Extracellular tyrosine-protein kinase PKDCC; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is es [...]
HAAO protein networkhttps://string-db.org/network/9606.ENSP000002949733-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
CAPN2 protein networkhttps://string-db.org/network/9606.ENSP00000295006Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteoly [...]
REL protein networkhttps://string-db.org/network/9606.ENSP00000295025Proto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is i [...]
PEX13 protein networkhttps://string-db.org/network/9606.ENSP00000295030Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10 [...]
RFTN2 protein networkhttps://string-db.org/network/9606.ENSP00000295049Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subseque [...]
SPRTN protein networkhttps://string-db.org/network/9606.ENSP00000295050SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion [...]
CAPN13 protein networkhttps://string-db.org/network/9606.ENSP00000295055Calpain-13; Probable non-lysosomal thiol-protease.
LRRTM1 protein networkhttps://string-db.org/network/9606.ENSP00000295057Leucine-rich repeat transmembrane neuronal protein 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level; Belo [...]
MEMO1 protein networkhttps://string-db.org/network/9606.ENSP00000295065Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays [...]
MAIP1 protein networkhttps://string-db.org/network/9606.ENSP00000295079m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor p [...]
KCNF1 protein networkhttps://string-db.org/network/9606.ENSP00000295082Potassium voltage-gated channel subfamily F member 1; Putative voltage-gated potassium channel.
SLC66A3 protein networkhttps://string-db.org/network/9606.ENSP00000295083Solute carrier family 66 member 3.
ARL5A protein networkhttps://string-db.org/network/9606.ENSP00000295087ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity; Belongs to the small GTPase superfamily. Arf family.
LRATD1 protein networkhttps://string-db.org/network/9606.ENSP00000295092Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family.
ARHGAP15 protein networkhttps://string-db.org/network/9606.ENSP00000295095Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in a [...]
KCNJ3 protein networkhttps://string-db.org/network/9606.ENSP00000295101G protein-activated inward rectifier potassium channel 1; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow [...]
NEUROD1 protein networkhttps://string-db.org/network/9606.ENSP00000295108Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associ [...]
FRZB protein networkhttps://string-db.org/network/9606.ENSP00000295113Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...]
NUP35 protein networkhttps://string-db.org/network/9606.ENSP00000295119Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components [...]
WDR92 protein networkhttps://string-db.org/network/9606.ENSP00000295121WD repeat-containing protein 92; Seems to act as a modulator of apoptosis.
CCDC138 protein networkhttps://string-db.org/network/9606.ENSP00000295124Coiled-coil domain containing 138.
ZSWIM2 protein networkhttps://string-db.org/network/9606.ENSP00000295131E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 [...]
WDCP protein networkhttps://string-db.org/network/9606.ENSP00000295148WD repeat and coiled coil containing.
FAM228A protein networkhttps://string-db.org/network/9606.ENSP00000295150Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family.
CCDC74A protein networkhttps://string-db.org/network/9606.ENSP00000295171Coiled-coil domain containing 74A.
SLC16A14 protein networkhttps://string-db.org/network/9606.ENSP00000295190Monocarboxylate transporter 14; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
TEKT4 protein networkhttps://string-db.org/network/9606.ENSP00000295201Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family.
EN1 protein networkhttps://string-db.org/network/9606.ENSP00000295206Homeobox protein engrailed-1; Engrailed homeobox 1.
ZNF514 protein networkhttps://string-db.org/network/9606.ENSP00000295208Zinc finger protein 514; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SPATA18 protein networkhttps://string-db.org/network/9606.ENSP00000295213Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochond [...]
KCNIP3 protein networkhttps://string-db.org/network/9606.ENSP00000295225Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding [...]
CCDC140 protein networkhttps://string-db.org/network/9606.ENSP00000295226Coiled-coil domain-containing protein 140; CCDC140 long non-coding RNA.
INHBB protein networkhttps://string-db.org/network/9606.ENSP00000295228Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...]
BBS5 protein networkhttps://string-db.org/network/9606.ENSP00000295240Bardet-Biedl syndrome 5 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...]
HPGDS protein networkhttps://string-db.org/network/9606.ENSP00000295256Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhi [...]
PDHA2 protein networkhttps://string-db.org/network/9606.ENSP00000295266Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), an [...]
STPG2 protein networkhttps://string-db.org/network/9606.ENSP00000295268Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2.
SLC9A4 protein networkhttps://string-db.org/network/9606.ENSP00000295269Sodium/hydrogen exchanger 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
C1QTNF7 protein networkhttps://string-db.org/network/9606.ENSP00000295297Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7.
CHAC2 protein networkhttps://string-db.org/network/9606.ENSP00000295304Glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma [...]
TMOD4 protein networkhttps://string-db.org/network/9606.ENSP00000295314Tropomodulin-4; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...]
RNF149 protein networkhttps://string-db.org/network/9606.ENSP00000295317E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
IWS1 protein networkhttps://string-db.org/network/9606.ENSP00000295321Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA [...]
BMP10 protein networkhttps://string-db.org/network/9606.ENSP00000295379Bone morphogenetic protein 10; Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KI [...]
MERTK protein networkhttps://string-db.org/network/9606.ENSP00000295408Tyrosine-protein kinase Mer; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. [...]
CCNYL1 protein networkhttps://string-db.org/network/9606.ENSP00000295414Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family. Cyclin Y subfamily.
GNPDA2 protein networkhttps://string-db.org/network/9606.ENSP00000295448Glucosamine-6-phosphate deaminase 2.
GABRG1 protein networkhttps://string-db.org/network/9606.ENSP00000295452Gamma-aminobutyric acid receptor subunit gamma-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
ALPG protein networkhttps://string-db.org/network/9606.ENSP00000295453Alkaline phosphatase, germ cell.
GABRB1 protein networkhttps://string-db.org/network/9606.ENSP00000295454Gamma-aminobutyric acid receptor subunit beta-1; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine re [...]
NIPAL1 protein networkhttps://string-db.org/network/9606.ENSP00000295461Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+ [...]
ALPI protein networkhttps://string-db.org/network/9606.ENSP00000295463Alkaline phosphatase, intestinal.
HELQ protein networkhttps://string-db.org/network/9606.ENSP00000295488Helicase POLQ-like; Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2- med [...]
MRPS18C protein networkhttps://string-db.org/network/9606.ENSP00000295491Mitochondrial ribosomal protein S18C.
CLDN1 protein networkhttps://string-db.org/network/9606.ENSP00000295522Claudin-1; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the forma [...]
DCST1 protein networkhttps://string-db.org/network/9606.ENSP00000295542E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I- [...]
COL6A3 protein networkhttps://string-db.org/network/9606.ENSP00000295550Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein.
TAFA4 protein networkhttps://string-db.org/network/9606.ENSP00000295569Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity (By similarity). Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS rel [...]
POGLUT1 protein networkhttps://string-db.org/network/9606.ENSP00000295588Protein O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in [...]
CCKAR protein networkhttps://string-db.org/network/9606.ENSP00000295589Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher a [...]
PROK2 protein networkhttps://string-db.org/network/9606.ENSP00000295619Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize outpu [...]
TEX55 protein networkhttps://string-db.org/network/9606.ENSP00000295622Testis expressed 55.
LRRC58 protein networkhttps://string-db.org/network/9606.ENSP00000295628Leucine-rich repeat-containing protein 58; Leucine rich repeat containing 58.
FSTL1 protein networkhttps://string-db.org/network/9606.ENSP00000295633Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity).
RNPEP protein networkhttps://string-db.org/network/9606.ENSP00000295640Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin a [...]
PDCL2 protein networkhttps://string-db.org/network/9606.ENSP00000295645Phosducin-like protein 2; May play a role in germ cell maturation; Belongs to the phosducin family.
IGFBP7 protein networkhttps://string-db.org/network/9606.ENSP00000295666Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
KRTCAP2 protein networkhttps://string-db.org/network/9606.ENSP00000295682Keratinocyte-associated protein 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the l [...]
CXCR1 protein networkhttps://string-db.org/network/9606.ENSP00000295683C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is [...]
ARPC2 protein networkhttps://string-db.org/network/9606.ENSP00000295685Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting fact [...]
CCT3 protein networkhttps://string-db.org/network/9606.ENSP00000295688T-complex protein 1 subunit gamma; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC comple [...]
TMEM79 protein networkhttps://string-db.org/network/9606.ENSP00000295694Transmembrane protein 79; Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial c [...]
SSR2 protein networkhttps://string-db.org/network/9606.ENSP00000295702Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Be [...]
RNF25 protein networkhttps://string-db.org/network/9606.ENSP00000295704E3 ubiquitin-protein ligase RNF25; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF [...]
STK36 protein networkhttps://string-db.org/network/9606.ENSP00000295709Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Cont [...]
PTPRN protein networkhttps://string-db.org/network/9606.ENSP00000295718Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancr [...]
FEV protein networkhttps://string-db.org/network/9606.ENSP00000295727Protein FEV; Functions as a transcriptional regulator. According to it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic n [...]
CRYBA2 protein networkhttps://string-db.org/network/9606.ENSP00000295728Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens.
IHH protein networkhttps://string-db.org/network/9606.ENSP00000295731Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with s [...]
CIP2A protein networkhttps://string-db.org/network/9606.ENSP00000295746Protein CIP2A; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.
RETNLB protein networkhttps://string-db.org/network/9606.ENSP00000295755Resistin-like beta; Probable hormone; Belongs to the resistin/FIZZ family.
TRAT1 protein networkhttps://string-db.org/network/9606.ENSP00000295756T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells.
HDAC11 protein networkhttps://string-db.org/network/9606.ENSP00000295757Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic re [...]
GLB1L protein networkhttps://string-db.org/network/9606.ENSP00000295759Beta-galactosidase-1-like protein; Probable glycosyl hydrolase.
CHCHD4 protein networkhttps://string-db.org/network/9606.ENSP00000295767Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of [...]
STT3B protein networkhttps://string-db.org/network/9606.ENSP00000295770Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined gl [...]
SERPINI1 protein networkhttps://string-db.org/network/9606.ENSP00000295777Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for [...]
PRKCI protein networkhttps://string-db.org/network/9606.ENSP00000295797Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B act [...]
RETSAT protein networkhttps://string-db.org/network/9606.ENSP00000295802All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-c [...]
EIF5A2 protein networkhttps://string-db.org/network/9606.ENSP00000295822Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of deca [...]
EFHB protein networkhttps://string-db.org/network/9606.ENSP00000295824EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) an [...]
FABP1 protein networkhttps://string-db.org/network/9606.ENSP00000295834Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, a [...]
ABI2 protein networkhttps://string-db.org/network/9606.ENSP00000295851Abl interactor 2; Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 t [...]
SPICE1 protein networkhttps://string-db.org/network/9606.ENSP00000295872Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis.
CCDC191 protein networkhttps://string-db.org/network/9606.ENSP00000295878Coiled-coil domain containing 191.
NKX6-1 protein networkhttps://string-db.org/network/9606.ENSP00000295886Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta c [...]
CDS1 protein networkhttps://string-db.org/network/9606.ENSP00000295887Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression [...]
WDFY3 protein networkhttps://string-db.org/network/9606.ENSP00000295888WD repeat and FYVE domain-containing protein 3; Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core au [...]
C3orf49 protein networkhttps://string-db.org/network/9606.ENSP00000295896Putative uncharacterized protein C3orf49; Chromosome 3 open reading frame 49.
ALB protein networkhttps://string-db.org/network/9606.ENSP00000295897Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is t [...]
C4orf36 protein networkhttps://string-db.org/network/9606.ENSP00000295898Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36.
THOC7 protein networkhttps://string-db.org/network/9606.ENSP00000295899THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, proc [...]
ATXN7 protein networkhttps://string-db.org/network/9606.ENSP00000295900Ataxin-7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary [...]
ERICH6 protein networkhttps://string-db.org/network/9606.ENSP00000295910Glutamate-rich protein 6; Glutamate rich 6.
CCNL1 protein networkhttps://string-db.org/network/9606.ENSP00000295926Cyclin-L1; Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of R [...]
PTX3 protein networkhttps://string-db.org/network/9606.ENSP00000295927Pentraxin-related protein PTX3; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility.
SMIM14 protein networkhttps://string-db.org/network/9606.ENSP00000295958Small integral membrane protein 14.
ABHD6 protein networkhttps://string-db.org/network/9606.ENSP00000295962Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regu [...]
C3orf67 protein networkhttps://string-db.org/network/9606.ENSP00000295966Uncharacterized protein C3orf67.
RBM47 protein networkhttps://string-db.org/network/9606.ENSP00000295971RNA binding motif protein 47; Belongs to the RRM RBM47 family.
IL17RC protein networkhttps://string-db.org/network/9606.ENSP00000295981Interleukin-17 receptor C; Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeri [...]
SYN1 protein networkhttps://string-db.org/network/9606.ENSP00000295987Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS [...]
PCOLCE2 protein networkhttps://string-db.org/network/9606.ENSP00000295992Procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.
MTMR14 protein networkhttps://string-db.org/network/9606.ENSP00000296003Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIn [...]
TTC14 protein networkhttps://string-db.org/network/9606.ENSP00000296015Tetratricopeptide repeat domain 14; Belongs to the TTC14 family.
CXCL3 protein networkhttps://string-db.org/network/9606.ENSP00000296026C-X-C motif chemokine 3; Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fas [...]
CXCL5 protein networkhttps://string-db.org/network/9606.ENSP00000296027C-X-C motif chemokine 5; Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes; Belongs to the interc [...]
PPBP protein networkhttps://string-db.org/network/9606.ENSP00000296028Connective tissue-activating peptide III(1-81); LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid [...]
PF4 protein networkhttps://string-db.org/network/9606.ENSP00000296029Platelet factor 4, short form; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate ch [...]
SHROOM3 protein networkhttps://string-db.org/network/9606.ENSP00000296043Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and [...]
CPA3 protein networkhttps://string-db.org/network/9606.ENSP00000296046Carboxypeptidase A3.
HPS3 protein networkhttps://string-db.org/network/9606.ENSP00000296051Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation.
TM4SF18 protein networkhttps://string-db.org/network/9606.ENSP00000296059Transmembrane 4 L six family member 18.
SNRK protein networkhttps://string-db.org/network/9606.ENSP00000296088SNF-related serine/threonine-protein kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
ZNF502 protein networkhttps://string-db.org/network/9606.ENSP00000296091Zinc finger protein 502; May be involved in transcriptional regulation.
TCF23 protein networkhttps://string-db.org/network/9606.ENSP00000296096Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodim [...]
DNAJC5G protein networkhttps://string-db.org/network/9606.ENSP00000296097DnaJ heat shock protein family member C5 gamma.
TRIM54 protein networkhttps://string-db.org/network/9606.ENSP00000296098Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation.
UCN protein networkhttps://string-db.org/network/9606.ENSP00000296099Urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Plays a role in the establishment [...]
MRPL33 protein networkhttps://string-db.org/network/9606.ENSP00000296102Mitochondrial ribosomal protein L33.
KIAA1143 protein networkhttps://string-db.org/network/9606.ENSP00000296121Uncharacterized protein KIAA1143; KIAA1143.
TGM4 protein networkhttps://string-db.org/network/9606.ENSP00000296125Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins i [...]
CDCP1 protein networkhttps://string-db.org/network/9606.ENSP00000296129CUB domain-containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiat [...]
CLEC3B protein networkhttps://string-db.org/network/9606.ENSP00000296130Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.
LZTFL1 protein networkhttps://string-db.org/network/9606.ENSP00000296135Leucine zipper transcription factor-like protein 1; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the [...]
FYCO1 protein networkhttps://string-db.org/network/9606.ENSP00000296137FYVE and coiled-coil domain-containing protein 1; May mediate microtubule plus end-directed vesicle transport.
CCR1 protein networkhttps://string-db.org/network/9606.ENSP00000296140C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- 1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP- 1 and subsequently transduces [...]
RTP3 protein networkhttps://string-db.org/network/9606.ENSP00000296142Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family.
TDGF1 protein networkhttps://string-db.org/network/9606.ENSP00000296145Teratocarcinoma-derived growth factor 1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modul [...]
ELP6 protein networkhttps://string-db.org/network/9606.ENSP00000296149Elongator complex protein 6; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in trans [...]
DTX3L protein networkhttps://string-db.org/network/9606.ENSP00000296161E3 ubiquitin-protein ligase DTX3L; E3 ubiquitin-protein ligase which, in association with ADP- ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral res [...]
ITGB5 protein networkhttps://string-db.org/network/9606.ENSP00000296181Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
SNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000296215Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved i [...]
DNALI1 protein networkhttps://string-db.org/network/9606.ENSP00000296218Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility.
OSBPL11 protein networkhttps://string-db.org/network/9606.ENSP00000296220Oxysterol-binding protein-related protein 11; Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage [...]
KLF15 protein networkhttps://string-db.org/network/9606.ENSP00000296233Krueppel-like factor 15; Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By sim [...]
CAMK2N2 protein networkhttps://string-db.org/network/9606.ENSP00000296238Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the re [...]
LIPH protein networkhttps://string-db.org/network/9606.ENSP00000296252Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phosphol [...]
RPN1 protein networkhttps://string-db.org/network/9606.ENSP00000296255Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Ma [...]
SENP2 protein networkhttps://string-db.org/network/9606.ENSP00000296257Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ub [...]
IFT122 protein networkhttps://string-db.org/network/9606.ENSP00000296266Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors [...]
RHO protein networkhttps://string-db.org/network/9606.ENSP00000296271Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light- induced isomerization of the chromophore 11-cis-re [...]
MASP1 protein networkhttps://string-db.org/network/9606.ENSP00000296280Mannan binding lectin serine peptidase 1.
RFT1 protein networkhttps://string-db.org/network/9606.ENSP00000296292Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmi [...]
IL17RD protein networkhttps://string-db.org/network/9606.ENSP00000296318Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nu [...]
ZDHHC19 protein networkhttps://string-db.org/network/9606.ENSP00000296326Palmitoyltransferase ZDHHC19; Palmitoyltransferase that mediates palmitoylation of STAT3 and RRAS. Palmitoylation of STAT3 induces the homodimerization and transcriptional activation of STAT3, th [...]
SLC51A protein networkhttps://string-db.org/network/9606.ENSP00000296327Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export [...]
UBXN7 protein networkhttps://string-db.org/network/9606.ENSP00000296328UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitinati [...]
PIGX protein networkhttps://string-db.org/network/9606.ENSP00000296333Phosphatidylinositol-glycan biosynthesis class X protein; Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor [...]
RUBCN protein networkhttps://string-db.org/network/9606.ENSP00000296343Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophag [...]
MELTF protein networkhttps://string-db.org/network/9606.ENSP00000296350Melanotransferrin; Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc.
OTOP1 protein networkhttps://string-db.org/network/9606.ENSP00000296358Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage (By similarity). Proton-selective chan [...]
S100P protein networkhttps://string-db.org/network/9606.ENSP00000296370Protein S100-P; May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, an [...]
CLDN19 protein networkhttps://string-db.org/network/9606.ENSP00000296387Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
METAP1 protein networkhttps://string-db.org/network/9606.ENSP00000296411Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence [...]
ADH5 protein networkhttps://string-db.org/network/9606.ENSP00000296412Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such [...]
H2AZ1 protein networkhttps://string-db.org/network/9606.ENSP00000296417Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machiner [...]
EMCN protein networkhttps://string-db.org/network/9606.ENSP00000296420Endomucin; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and [...]
SLC9B1 protein networkhttps://string-db.org/network/9606.ENSP00000296422Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Belongs to the monovalent cati [...]
BDH2 protein networkhttps://string-db.org/network/9606.ENSP000002964243-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial entero [...]
CAMP protein networkhttps://string-db.org/network/9606.ENSP00000296435Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity.
FBXW12 protein networkhttps://string-db.org/network/9606.ENSP00000296438F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
SHISA5 protein networkhttps://string-db.org/network/9606.ENSP00000296444Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis.
BSN protein networkhttps://string-db.org/network/9606.ENSP00000296452Protein bassoon; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the [...]
APEH protein networkhttps://string-db.org/network/9606.ENSP00000296456Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N- [...]
HSPA4L protein networkhttps://string-db.org/network/9606.ENSP00000296464Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family.
MON1A protein networkhttps://string-db.org/network/9606.ENSP00000296473Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts i [...]
MST1R protein networkhttps://string-db.org/network/9606.ENSP00000296474Macrophage-stimulating protein receptor alpha chain; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many ph [...]
POC1A protein networkhttps://string-db.org/network/9606.ENSP00000296484POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps [...]
ETNPPL protein networkhttps://string-db.org/network/9606.ENSP00000296486Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde.
WDR82 protein networkhttps://string-db.org/network/9606.ENSP00000296490WD repeat-containing protein 82; Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4 [...]
PRSS12 protein networkhttps://string-db.org/network/9606.ENSP00000296498Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 fa [...]
NDST3 protein networkhttps://string-db.org/network/9606.ENSP00000296499Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...]
HMGB2 protein networkhttps://string-db.org/network/9606.ENSP00000296503High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associa [...]
SAP30 protein networkhttps://string-db.org/network/9606.ENSP00000296504Histone deacetylase complex subunit SAP30; Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of tr [...]
SCRG1 protein networkhttps://string-db.org/network/9606.ENSP00000296506Scrapie-responsive protein 1; Stimulator of chondrogenesis 1.
MAD2L1 protein networkhttps://string-db.org/network/9606.ENSP00000296509Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase pla [...]
ANXA5 protein networkhttps://string-db.org/network/9606.ENSP00000296511Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
ADAD1 protein networkhttps://string-db.org/network/9606.ENSP00000296513Adenosine deaminase domain-containing protein 1; Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).
GUCY1A1 protein networkhttps://string-db.org/network/9606.ENSP00000296518Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
HPGD protein networkhttps://string-db.org/network/9606.ENSP0000029652215-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent [...]
ASB5 protein networkhttps://string-db.org/network/9606.ENSP00000296525Ankyrin repeat and SOCS box protein 5; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
GRIA2 protein networkhttps://string-db.org/network/9606.ENSP00000296526Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...]
TMEM144 protein networkhttps://string-db.org/network/9606.ENSP00000296529Transmembrane protein 144; Belongs to the TMEM144 family.
NAA15 protein networkhttps://string-db.org/network/9606.ENSP00000296543N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT [...]
IL15 protein networkhttps://string-db.org/network/9606.ENSP00000296545Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2 [...]
ARFIP1 protein networkhttps://string-db.org/network/9606.ENSP00000296557Arfaptin-1; Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network. Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms [...]
ICE1 protein networkhttps://string-db.org/network/9606.ENSP00000296564Little elongation complex subunit 1; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Sp [...]
HHIP protein networkhttps://string-db.org/network/9606.ENSP00000296575Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family; Belongs to the HHIP famil [...]
ABCE1 protein networkhttps://string-db.org/network/9606.ENSP00000296577ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhi [...]
LSM6 protein networkhttps://string-db.org/network/9606.ENSP00000296581U6 snRNA-associated Sm-like protein LSm6; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
TMEM184C protein networkhttps://string-db.org/network/9606.ENSP00000296582Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family.
ITGA2 protein networkhttps://string-db.org/network/9606.ENSP00000296585Integrin alpha-2; Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in c [...]
SLC45A2 protein networkhttps://string-db.org/network/9606.ENSP00000296589Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuron [...]
EDIL3 protein networkhttps://string-db.org/network/9606.ENSP00000296591EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascu [...]
NDUFAF2 protein networkhttps://string-db.org/network/9606.ENSP00000296597NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NAD [...]
ZNF474 protein networkhttps://string-db.org/network/9606.ENSP00000296600Zinc finger protein 474.
LMBRD2 protein networkhttps://string-db.org/network/9606.ENSP00000296603G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also r [...]
STARD4 protein networkhttps://string-db.org/network/9606.ENSP00000296632StAR-related lipid transfer protein 4; Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.
F2RL2 protein networkhttps://string-db.org/network/9606.ENSP00000296641Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
ANKRD33B protein networkhttps://string-db.org/network/9606.ENSP00000296657Ankyrin repeat domain 33B.
CMBL protein networkhttps://string-db.org/network/9606.ENSP00000296658Carboxymethylenebutenolidase homolog; Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, i [...]
RPS23 protein networkhttps://string-db.org/network/9606.ENSP0000029667440S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RN [...]
F2RL1 protein networkhttps://string-db.org/network/9606.ENSP00000296677Proteinase-activated receptor 2, alternate cleaved 1; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pat [...]
WDR41 protein networkhttps://string-db.org/network/9606.ENSP00000296679WD repeat-containing protein 41; Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SM [...]
PRDM9 protein networkhttps://string-db.org/network/9606.ENSP00000296682Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively [...]
NDUFS4 protein networkhttps://string-db.org/network/9606.ENSP00000296684NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be [...]
SCGB3A2 protein networkhttps://string-db.org/network/9606.ENSP00000296694Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram [...]
SPINK1 protein networkhttps://string-db.org/network/9606.ENSP00000296695Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin- catalyzed premature activation of zymogens (By s [...]
TCERG1 protein networkhttps://string-db.org/network/9606.ENSP00000296702Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a T [...]
AFAP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000296721Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation.
TIGD6 protein networkhttps://string-db.org/network/9606.ENSP00000296736Tigger transposable element derived 6.
ENPP6 protein networkhttps://string-db.org/network/9606.ENSP00000296741Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to su [...]
ERAP1 protein networkhttps://string-db.org/network/9606.ENSP00000296754Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is [...]
MAP1B protein networkhttps://string-db.org/network/9606.ENSP00000296755Microtubule-associated protein 1B; Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accomp [...]
TMEM174 protein networkhttps://string-db.org/network/9606.ENSP00000296776Transmembrane protein 174.
CARTPT protein networkhttps://string-db.org/network/9606.ENSP00000296777Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation- [...]
RICTOR protein networkhttps://string-db.org/network/9606.ENSP00000296782Rapamycin-insensitive companion of mTOR; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mT [...]
ANKRA2 protein networkhttps://string-db.org/network/9606.ENSP00000296785Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity).
UBLCP1 protein networkhttps://string-db.org/network/9606.ENSP00000296786Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core [...]
UTP15 protein networkhttps://string-db.org/network/9606.ENSP00000296792U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription b [...]
TLR3 protein networkhttps://string-db.org/network/9606.ENSP00000296795Toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific [...]
CCDC127 protein networkhttps://string-db.org/network/9606.ENSP00000296824Coiled-coil domain containing 127.
FOXQ1 protein networkhttps://string-db.org/network/9606.ENSP00000296839Forkhead box protein Q1; Plays a role in hair follicle differentiation.
NKD2 protein networkhttps://string-db.org/network/9606.ENSP00000296849Protein naked cuticle homolog 2; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). [...]
RAPGEF6 protein networkhttps://string-db.org/network/9606.ENSP00000296859Rap guanine nucleotide exchange factor 6; Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
TNFRSF21 protein networkhttps://string-db.org/network/9606.ENSP00000296861Tumor necrosis factor receptor superfamily member 21; Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the [...]
ADGRF2 protein networkhttps://string-db.org/network/9606.ENSP00000296862Adhesion G-protein coupled receptor F2; Orphan receptor.
IL3 protein networkhttps://string-db.org/network/9606.ENSP00000296870Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell popul [...]
CSF2 protein networkhttps://string-db.org/network/9606.ENSP00000296871Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophag [...]
LEAP2 protein networkhttps://string-db.org/network/9606.ENSP00000296877Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity; Belongs to the LEAP2 family.
TLX3 protein networkhttps://string-db.org/network/9606.ENSP00000296921T cell leukemia homeobox 3.
NPM1 protein networkhttps://string-db.org/network/9606.ENSP00000296930Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppr [...]
TBXT protein networkhttps://string-db.org/network/9606.ENSP00000296946T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates ge [...]
CREBRF protein networkhttps://string-db.org/network/9606.ENSP00000296953CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the U [...]
DCBLD1 protein networkhttps://string-db.org/network/9606.ENSP00000296955Discoidin, CUB and LCCL domain containing 1.
IL22RA2 protein networkhttps://string-db.org/network/9606.ENSP00000296980Interleukin-22 receptor subunit alpha-2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May p [...]
SPATA48 protein networkhttps://string-db.org/network/9606.ENSP00000297001Spermatogenesis-associated protein 48; Spermatogenesis associated 48.
H2AC1 protein networkhttps://string-db.org/network/9606.ENSP00000297012Histone H2A type 1-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
SCIN protein networkhttps://string-db.org/network/9606.ENSP00000297029Adseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. [...]
CYTH3 protein networkhttps://string-db.org/network/9606.ENSP00000297044Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By sim [...]
DAGLB protein networkhttps://string-db.org/network/9606.ENSP00000297056Sn1-specific diacylglycerol lipase beta; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal gro [...]
KIAA0895 protein networkhttps://string-db.org/network/9606.ENSP00000297063Uncharacterized protein KIAA0895; KIAA0895.
TRA2A protein networkhttps://string-db.org/network/9606.ENSP00000297071Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
GALNT10 protein networkhttps://string-db.org/network/9606.ENSP00000297107Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
SAP30L protein networkhttps://string-db.org/network/9606.ENSP00000297109Histone deacetylase complex subunit SAP30L; [Isoform 1]: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitm [...]
MYOZ3 protein networkhttps://string-db.org/network/9606.ENSP00000297130Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...]
COG5 protein networkhttps://string-db.org/network/9606.ENSP00000297135Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family.
NEUROD6 protein networkhttps://string-db.org/network/9606.ENSP00000297142Neurogenic differentiation factor 6; Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammal [...]
BMT2 protein networkhttps://string-db.org/network/9606.ENSP00000297145S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts a [...]
GPR85 protein networkhttps://string-db.org/network/9606.ENSP00000297146Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
SLU7 protein networkhttps://string-db.org/network/9606.ENSP00000297151Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon [...]
CAMLG protein networkhttps://string-db.org/network/9606.ENSP00000297156Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
RP9 protein networkhttps://string-db.org/network/9606.ENSP00000297157Retinitis pigmentosa 9 protein; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity).
RELL2 protein networkhttps://string-db.org/network/9606.ENSP00000297164RELT-like protein 2; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed ; Belongs to the RELT family.
HSPA9 protein networkhttps://string-db.org/network/9606.ENSP00000297185Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly protein [...]
TEX47 protein networkhttps://string-db.org/network/9606.ENSP00000297203Testis-expressed protein 47; Testis expressed 47.
STEAP1 protein networkhttps://string-db.org/network/9606.ENSP00000297205Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor.
FABP5 protein networkhttps://string-db.org/network/9606.ENSP00000297258Fatty acid-binding protein 5; Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands the [...]
SHH protein networkhttps://string-db.org/network/9606.ENSP00000297261Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By simi [...]
CHMP4C protein networkhttps://string-db.org/network/9606.ENSP00000297265Charged multivesicular body protein 4c; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
FNDC1 protein networkhttps://string-db.org/network/9606.ENSP00000297267Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling.
COL1A2 protein networkhttps://string-db.org/network/9606.ENSP00000297268Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family.
CASD1 protein networkhttps://string-db.org/network/9606.ENSP00000297273N-acetylneuraminate 9-O-acetyltransferase; O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and ar [...]
SLC13A4 protein networkhttps://string-db.org/network/9606.ENSP00000297282Solute carrier family 13 member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV).
PGAM2 protein networkhttps://string-db.org/network/9606.ENSP00000297283Phosphoglycerate mutase 2; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but w [...]
BRI3 protein networkhttps://string-db.org/network/9606.ENSP00000297290Brain protein I3; Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver ; Belongs to the BRI3 family.
LMTK2 protein networkhttps://string-db.org/network/9606.ENSP00000297293Serine/threonine-protein kinase LMTK2; Phosphorylates PPP1C, phosphorylase b and CFTR; Belongs to the protein kinase superfamily. Tyr protein kinase family.
SLC35G3 protein networkhttps://string-db.org/network/9606.ENSP00000297307Solute carrier family 35 member G3.
RGS20 protein networkhttps://string-db.org/network/9606.ENSP00000297313Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds sele [...]
SOX17 protein networkhttps://string-db.org/network/9606.ENSP00000297316Transcription factor SOX-17; Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'- AACAAAG-3'. Modulates transcriptional reg [...]
ADCY1 protein networkhttps://string-db.org/network/9606.ENSP00000297323Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similari [...]
C8orf48 protein networkhttps://string-db.org/network/9606.ENSP00000297324Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48.
SUN3 protein networkhttps://string-db.org/network/9606.ENSP00000297325SUN domain-containing protein 3; As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleto [...]
RAD21 protein networkhttps://string-db.org/network/9606.ENSP00000297338Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DN [...]
MED30 protein networkhttps://string-db.org/network/9606.ENSP00000297347Mediator of RNA polymerase II transcription subunit 30; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
TNFRSF11B protein networkhttps://string-db.org/network/9606.ENSP00000297350Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts [...]
SBSPON protein networkhttps://string-db.org/network/9606.ENSP00000297354Somatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family.
EN2 protein networkhttps://string-db.org/network/9606.ENSP00000297375Homeobox protein engrailed-2; Engrailed homeobox 2; Belongs to the engrailed homeobox family.
CSMD3 protein networkhttps://string-db.org/network/9606.ENSP00000297405CUB and sushi domain-containing protein 3; Involved in dendrite development.
SPIDR protein networkhttps://string-db.org/network/9606.ENSP00000297423DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DN [...]
ORC5 protein networkhttps://string-db.org/network/9606.ENSP00000297431Origin recognition complex subunit 5; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...]
DEFA4 protein networkhttps://string-db.org/network/9606.ENSP00000297435Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with [...]
DEFA6 protein networkhttps://string-db.org/network/9606.ENSP00000297436Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
DEFB1 protein networkhttps://string-db.org/network/9606.ENSP00000297439Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Bind [...]
DNAAF5 protein networkhttps://string-db.org/network/9606.ENSP00000297440Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and out [...]
TMEM74 protein networkhttps://string-db.org/network/9606.ENSP00000297459Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction. Belongs to the TMEM74 family.
TMEM184A protein networkhttps://string-db.org/network/9606.ENSP00000297477Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).
NOS3 protein networkhttps://string-db.org/network/9606.ENSP00000297494Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular e [...]
ABCB8 protein networkhttps://string-db.org/network/9606.ENSP00000297504Mitochondrial potassium channel ATP-binding subunit; ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane. Together with CCDC51/MITOK, forms a pr [...]
MICALL2 protein networkhttps://string-db.org/network/9606.ENSP00000297508MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin [...]
ASIC3 protein networkhttps://string-db.org/network/9606.ENSP00000297512Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast [...]
SLC7A13 protein networkhttps://string-db.org/network/9606.ENSP00000297524Solute carrier family 7 member 13; Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
FASTK protein networkhttps://string-db.org/network/9606.ENSP00000297532Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro- apoptotic form of the rece [...]
FMC1 protein networkhttps://string-db.org/network/9606.ENSP00000297534Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) ; Belongs to the FMC1 family.
GBX1 protein networkhttps://string-db.org/network/9606.ENSP00000297537Homeobox protein GBX-1; Gastrulation brain homeobox 1.
PHAX protein networkhttps://string-db.org/network/9606.ENSP00000297540Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding c [...]
SLC25A32 protein networkhttps://string-db.org/network/9606.ENSP00000297578Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane.
DCAF13 protein networkhttps://string-db.org/network/9606.ENSP00000297579DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to [...]
DCSTAMP protein networkhttps://string-db.org/network/9606.ENSP00000297581Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF [...]
VIRMA protein networkhttps://string-db.org/network/9606.ENSP00000297591Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRN [...]
GEM protein networkhttps://string-db.org/network/9606.ENSP00000297596GTP-binding protein GEM; Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetec [...]
RPP25L protein networkhttps://string-db.org/network/9606.ENSP00000297613Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP.
C9orf24 protein networkhttps://string-db.org/network/9606.ENSP00000297623Spermatid-specific manchette-related protein 1; May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells. Belongs to the SMRP1 family.
MYORG protein networkhttps://string-db.org/network/9606.ENSP00000297625Myogenesis-regulating glycosidase; Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2.
TMEM65 protein networkhttps://string-db.org/network/9606.ENSP00000297632Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the [...]
CNTNAP3 protein networkhttps://string-db.org/network/9606.ENSP00000297668Contactin-associated protein-like 3; Contactin associated protein family member 3.
HSD3B7 protein networkhttps://string-db.org/network/9606.ENSP000002976793 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hy [...]
NFIL3 protein networkhttps://string-db.org/network/9606.ENSP00000297689Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and vi [...]
ZMAT4 protein networkhttps://string-db.org/network/9606.ENSP00000297737Zinc finger matrin-type 4.
PRSS37 protein networkhttps://string-db.org/network/9606.ENSP00000297767Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation [...]
CPA6 protein networkhttps://string-db.org/network/9606.ENSP00000297770Carboxypeptidase A6; May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensi [...]
ALDH1A1 protein networkhttps://string-db.org/network/9606.ENSP00000297785Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity [...]
CCDC136 protein networkhttps://string-db.org/network/9606.ENSP00000297788Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization.
KDM1B protein networkhttps://string-db.org/network/9606.ENSP00000297792Lysine demethylase 1B.
KIF27 protein networkhttps://string-db.org/network/9606.ENSP00000297814Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis.
SSMEM1 protein networkhttps://string-db.org/network/9606.ENSP00000297819Serine rich single-pass membrane protein 1.
ANKS6 protein networkhttps://string-db.org/network/9606.ENSP00000297837Ankyrin repeat and SAM domain-containing protein 6; Required for renal function.
COL14A1 protein networkhttps://string-db.org/network/9606.ENSP00000297848Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then [...]
ZHX1 protein networkhttps://string-db.org/network/9606.ENSP00000297857Zinc fingers and homeoboxes protein 1; Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule betwee [...]
METTL27 protein networkhttps://string-db.org/network/9606.ENSP00000297873Methyltransferase-like protein 27; Methyltransferase like 27.
VEGFD protein networkhttps://string-db.org/network/9606.ENSP00000297904Vascular endothelial growth factor D; Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on th [...]
OR1Q1 protein networkhttps://string-db.org/network/9606.ENSP00000297913Olfactory receptor 1Q1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
WNK2 protein networkhttps://string-db.org/network/9606.ENSP00000297954Serine/threonine-protein kinase WNK2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an a [...]
AQP7 protein networkhttps://string-db.org/network/9606.ENSP00000297988Aquaporin-7; Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH. The channel is also permeable to urea. Plays an important role in body energy homeosta [...]
NOL6 protein networkhttps://string-db.org/network/9606.ENSP00000297990Nucleolar protein 6; Belongs to the NRAP family.
AQP3 protein networkhttps://string-db.org/network/9606.ENSP00000297991Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC [...]
TRMT10B protein networkhttps://string-db.org/network/9606.ENSP00000297994tRNA methyltransferase 10 homolog B; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably n [...]
ARMC3 protein networkhttps://string-db.org/network/9606.ENSP00000298032Armadillo repeat containing 3.
MELK protein networkhttps://string-db.org/network/9606.ENSP00000298048Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulatio [...]
DEUP1 protein networkhttps://string-db.org/network/9606.ENSP00000298050Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole ampli [...]
FBXO33 protein networkhttps://string-db.org/network/9606.ENSP00000298097F-box only protein 33; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...]
LRFN5 protein networkhttps://string-db.org/network/9606.ENSP00000298119Leucine-rich repeat and fibronectin type-III domain-containing protein 5; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgr [...]
WDFY2 protein networkhttps://string-db.org/network/9606.ENSP00000298125WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-depende [...]
SPTSSA protein networkhttps://string-db.org/network/9606.ENSP00000298130Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrat [...]
WRN protein networkhttps://string-db.org/network/9606.ENSP00000298139Werner syndrome ATP-dependent helicase; Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a [...]
CFL2 protein networkhttps://string-db.org/network/9606.ENSP00000298159Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability [...]
SSX7 protein networkhttps://string-db.org/network/9606.ENSP00000298181Protein SSX7; Could act as a modulator of transcription; Belongs to the SSX family.
PGM2L1 protein networkhttps://string-db.org/network/9606.ENSP00000298198Glucose 1,6-bisphosphate synthase; Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosp [...]
FOLR2 protein networkhttps://string-db.org/network/9606.ENSP00000298223Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for fol [...]
INPPL1 protein networkhttps://string-db.org/network/9606.ENSP00000298229Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIn [...]
PHOX2A protein networkhttps://string-db.org/network/9606.ENSP00000298231Paired mesoderm homeobox protein 2A; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain [...]
CRYL1 protein networkhttps://string-db.org/network/9606.ENSP00000298248Lambda-crystallin homolog; Crystallin lambda 1.
HEPACAM protein networkhttps://string-db.org/network/9606.ENSP00000298251Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.
PCF11 protein networkhttps://string-db.org/network/9606.ENSP00000298281Pre-mRNA cleavage complex 2 protein Pcf11; Component of pre-mRNA cleavage complex II.
PKNOX2 protein networkhttps://string-db.org/network/9606.ENSP00000298282Homeobox protein PKNOX2; PBX/knotted 1 homeobox 2; Belongs to the TALE/MEIS homeobox family.
RPL10L protein networkhttps://string-db.org/network/9606.ENSP0000029828360S ribosomal protein L10-like; May play a role in compensating for the inactivated X-linked gene during spermatogenesis.
LRR1 protein networkhttps://string-db.org/network/9606.ENSP00000298288Leucine-rich repeat protein 1; May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS [...]
DNAAF2 protein networkhttps://string-db.org/network/9606.ENSP00000298292Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in t [...]
DEPP1 protein networkhttps://string-db.org/network/9606.ENSP00000298295Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS.
MAGEC3 protein networkhttps://string-db.org/network/9606.ENSP00000298296Melanoma-associated antigen C3; MAGE family member C3.
ZNF22 protein networkhttps://string-db.org/network/9606.ENSP00000298299Zinc finger protein 22; Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity).
KLHDC2 protein networkhttps://string-db.org/network/9606.ENSP00000298307Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
NEMF protein networkhttps://string-db.org/network/9606.ENSP00000298310Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized [...]
ARF6 protein networkhttps://string-db.org/network/9606.ENSP00000298316ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesi [...]
RPUSD4 protein networkhttps://string-db.org/network/9606.ENSP00000298317Mitochondrial RNA pseudouridine synthase RPUSD4; Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitoc [...]
TMEM63C protein networkhttps://string-db.org/network/9606.ENSP00000298351Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By s [...]
NGB protein networkhttps://string-db.org/network/9606.ENSP00000298352Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell [...]
TRIM9 protein networkhttps://string-db.org/network/9606.ENSP00000298355E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation [...]
AKR1E2 protein networkhttps://string-db.org/network/9606.ENSP000002983751,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH- dependent reductase activity to [...]
RXFP2 protein networkhttps://string-db.org/network/9606.ENSP00000298386Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for L [...]
SSX3 protein networkhttps://string-db.org/network/9606.ENSP00000298396Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family.
SEC61A2 protein networkhttps://string-db.org/network/9606.ENSP00000298428Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membran [...]
OXGR1 protein networkhttps://string-db.org/network/9606.ENSP000002984402-oxoglutarate receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).
ABRAXAS2 protein networkhttps://string-db.org/network/9606.ENSP00000298492BRISC complex subunit Abraxas 2; Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its s [...]
PRDX3 protein networkhttps://string-db.org/network/9606.ENSP00000298510Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively [...]
CLEC1B protein networkhttps://string-db.org/network/9606.ENSP00000298527C-type lectin domain family 1 member B; C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequenti [...]
SNAPC4 protein networkhttps://string-db.org/network/9606.ENSP00000298532snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...]
FRMD7 protein networkhttps://string-db.org/network/9606.ENSP00000298542FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability.
AK8 protein networkhttps://string-db.org/network/9606.ENSP00000298545Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest a [...]
TSC1 protein networkhttps://string-db.org/network/9606.ENSP00000298552Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required [...]
HPRT1 protein networkhttps://string-db.org/network/9606.ENSP00000298556Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosyl [...]
KIAA1191 protein networkhttps://string-db.org/network/9606.ENSP00000298569Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth; Belongs to the P33MONOX fa [...]
DUSP16 protein networkhttps://string-db.org/network/9606.ENSP00000298573Dual specificity protein phosphatase 16; Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
ZMYND19 protein networkhttps://string-db.org/network/9606.ENSP00000298585Zinc finger MYND domain-containing protein 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling.
STOX1 protein networkhttps://string-db.org/network/9606.ENSP00000298596Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of [...]
STK32C protein networkhttps://string-db.org/network/9606.ENSP00000298630Serine/threonine kinase 32C; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SLC39A2 protein networkhttps://string-db.org/network/9606.ENSP00000298681Zinc transporter ZIP2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cat [...]
RNASE7 protein networkhttps://string-db.org/network/9606.ENSP00000298690Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) agai [...]
ARHGEF40 protein networkhttps://string-db.org/network/9606.ENSP00000298694Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF).
C12orf50 protein networkhttps://string-db.org/network/9606.ENSP00000298699Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50.
PPP1R36 protein networkhttps://string-db.org/network/9606.ENSP00000298705Protein phosphatase 1 regulatory subunit 36; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
METTL3 protein networkhttps://string-db.org/network/9606.ENSP00000298717N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regu [...]
ERICH6B protein networkhttps://string-db.org/network/9606.ENSP00000298738Glutamate-rich protein 6B; Glutamate rich 6B.
GAS1 protein networkhttps://string-db.org/network/9606.ENSP00000298743Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
TRUB1 protein networkhttps://string-db.org/network/9606.ENSP00000298746Probable tRNA pseudouridine synthase 1; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harborin [...]
WAPL protein networkhttps://string-db.org/network/9606.ENSP00000298767Wings apart-like protein homolog; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion durin [...]
SHLD2 protein networkhttps://string-db.org/network/9606.ENSP00000298786Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex f [...]
ARHGAP42 protein networkhttps://string-db.org/network/9606.ENSP00000298815Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle.
TTLL5 protein networkhttps://string-db.org/network/9606.ENSP00000298832Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather tha [...]
RAPSN protein networkhttps://string-db.org/network/9606.ENSP0000029885443 kDa receptor-associated protein of the synapse; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the recept [...]
CPSF2 protein networkhttps://string-db.org/network/9606.ENSP00000298875Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...]
CAPRIN2 protein networkhttps://string-db.org/network/9606.ENSP00000298892Caprin-2; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY du [...]
LRRK2 protein networkhttps://string-db.org/network/9606.ENSP00000298910Leucine-rich repeat serine/threonine-protein kinase 2; Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, a [...]
CLMN protein networkhttps://string-db.org/network/9606.ENSP00000298912Calmin.
NELL1 protein networkhttps://string-db.org/network/9606.ENSP00000298925Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
C1QL3 protein networkhttps://string-db.org/network/9606.ENSP00000298943Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose [...]
SMCO4 protein networkhttps://string-db.org/network/9606.ENSP00000298966Single-pass membrane protein with coiled-coil domains 4; Belongs to the SMCO4 family.
PIWIL4 protein networkhttps://string-db.org/network/9606.ENSP00000299001Piwi-like protein 4; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarit [...]
LIPC protein networkhttps://string-db.org/network/9606.ENSP00000299022Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL m [...]
TCP11L2 protein networkhttps://string-db.org/network/9606.ENSP00000299045T-complex protein 11-like protein 2; T-complex 11 like 2; Belongs to the TCP11 family.
SPRED1 protein networkhttps://string-db.org/network/9606.ENSP00000299084Sprouty-related, EVH1 domain-containing protein 1; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By [...]
C14orf93 protein networkhttps://string-db.org/network/9606.ENSP00000299088Uncharacterized protein C14orf93; Chromosome 14 open reading frame 93.
JAM3 protein networkhttps://string-db.org/network/9606.ENSP00000299106Junctional adhesion molecule C; Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role [...]
VPS35 protein networkhttps://string-db.org/network/9606.ENSP00000299138Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...]
SPATA19 protein networkhttps://string-db.org/network/9606.ENSP00000299140Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis.
AMN protein networkhttps://string-db.org/network/9606.ENSP00000299155Soluble protein amnionless; Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex form [...]
IKBIP protein networkhttps://string-db.org/network/9606.ENSP00000299157IKBKB interacting protein.
FOXN4 protein networkhttps://string-db.org/network/9606.ENSP00000299162Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing t [...]
HIF1AN protein networkhttps://string-db.org/network/9606.ENSP00000299163Hypoxia-inducible factor 1-alpha inhibitor; Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the [...]
ADAMTS15 protein networkhttps://string-db.org/network/9606.ENSP00000299164ADAM metallopeptidase with thrombospondin type 1 motif 15.
NDUFB8 protein networkhttps://string-db.org/network/9606.ENSP00000299166NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...]
AVPR1A protein networkhttps://string-db.org/network/9606.ENSP00000299178Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has b [...]
C16orf78 protein networkhttps://string-db.org/network/9606.ENSP00000299191Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78.
HEATR3 protein networkhttps://string-db.org/network/9606.ENSP00000299192HEAT repeat containing 3.
CKB protein networkhttps://string-db.org/network/9606.ENSP00000299198Creatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy tran [...]
LARP6 protein networkhttps://string-db.org/network/9606.ENSP00000299213La-related protein 6; Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure [...]
ZNF319 protein networkhttps://string-db.org/network/9606.ENSP00000299237Zinc finger protein 319; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HPS6 protein networkhttps://string-db.org/network/9606.ENSP00000299238Hermansky-Pudlak syndrome 6 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as cargo adap [...]
COPS2 protein networkhttps://string-db.org/network/9606.ENSP00000299259COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential [...]
CHODL protein networkhttps://string-db.org/network/9606.ENSP00000299295Chondrolectin; May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.
PCBD1 protein networkhttps://string-db.org/network/9606.ENSP00000299299Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator [...]
CCT2 protein networkhttps://string-db.org/network/9606.ENSP00000299300T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex [...]
TMEM132B protein networkhttps://string-db.org/network/9606.ENSP00000299308Transmembrane protein 132B; Belongs to the TMEM132 family.
GNPTAB protein networkhttps://string-db.org/network/9606.ENSP00000299314N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residu [...]
C16orf71 protein networkhttps://string-db.org/network/9606.ENSP00000299320Uncharacterized protein C16orf71; Chromosome 16 open reading frame 71.
COX11 protein networkhttps://string-db.org/network/9606.ENSP00000299335Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B [...]
FAM227B protein networkhttps://string-db.org/network/9606.ENSP00000299338Protein FAM227B; Family with sequence similarity 227 member B.
CLDN10 protein networkhttps://string-db.org/network/9606.ENSP00000299339Claudin-10; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular e [...]
CYYR1 protein networkhttps://string-db.org/network/9606.ENSP00000299340Cysteine and tyrosine rich 1.
C2 protein networkhttps://string-db.org/network/9606.ENSP00000299367Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, th [...]
TRIM44 protein networkhttps://string-db.org/network/9606.ENSP00000299413Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regu [...]
CCDC182 protein networkhttps://string-db.org/network/9606.ENSP00000299415Coiled-coil domain containing 182.
TAF10 protein networkhttps://string-db.org/network/9606.ENSP00000299424Transcription initiation factor TFIID subunit 10; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a [...]
TPP1 protein networkhttps://string-db.org/network/9606.ENSP00000299427Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products pro [...]
MSS51 protein networkhttps://string-db.org/network/9606.ENSP00000299432Putative protein MSS51 homolog, mitochondrial; MSS51 mitochondrial translational activator.
RAG1 protein networkhttps://string-db.org/network/9606.ENSP00000299440V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assem [...]
DCHS1 protein networkhttps://string-db.org/network/9606.ENSP00000299441Protocadherin-16; Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis [...]
POTED protein networkhttps://string-db.org/network/9606.ENSP00000299443POTE ankyrin domain family member D; Belongs to the POTE family.
OR10A5 protein networkhttps://string-db.org/network/9606.ENSP00000299454Olfactory receptor 10A5; Odorant receptor (Potential). May be involved in taste perception.
OR2D2 protein networkhttps://string-db.org/network/9606.ENSP00000299459Olfactory receptor 2D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
NLRP14 protein networkhttps://string-db.org/network/9606.ENSP00000299481NACHT, LRR and PYD domains-containing protein 14; May be involved in inflammation and spermatogenesis.
PPFIBP2 protein networkhttps://string-db.org/network/9606.ENSP00000299492Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Belongs to the liprin family. Liprin-beta subfamily.
KIAA0355 protein networkhttps://string-db.org/network/9606.ENSP00000299505Uncharacterized protein KIAA0355.
IDH3A protein networkhttps://string-db.org/network/9606.ENSP00000299518Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer comp [...]
CRABP1 protein networkhttps://string-db.org/network/9606.ENSP00000299529Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors; Belongs to the calycin superfamily. Fatty-acid binding [...]
RNF169 protein networkhttps://string-db.org/network/9606.ENSP00000299563E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair site [...]
CHRNA5 protein networkhttps://string-db.org/network/9606.ENSP00000299565Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
ATMIN protein networkhttps://string-db.org/network/9606.ENSP00000299575ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absen [...]
C16orf46 protein networkhttps://string-db.org/network/9606.ENSP00000299578Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46.
LEO1 protein networkhttps://string-db.org/network/9606.ENSP00000299601RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development [...]
TMX3 protein networkhttps://string-db.org/network/9606.ENSP00000299608Protein disulfide-isomerase TMX3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.
ALG8 protein networkhttps://string-db.org/network/9606.ENSP00000299626Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers [...]
HDGFL3 protein networkhttps://string-db.org/network/9606.ENSP00000299633Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation.
POLR2M protein networkhttps://string-db.org/network/9606.ENSP00000299638DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many [...]
CLEC4E protein networkhttps://string-db.org/network/9606.ENSP00000299663C-type lectin domain family 4 member E; A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) [...]
CLEC4D protein networkhttps://string-db.org/network/9606.ENSP00000299665C-type lectin domain family 4 member D; A calcium-dependent lectin involved in innate recognition of pathogen-associated molecular patterns (PAMPs). Interacts with signaling adapter Fc receptor g [...]
ZNF407 protein networkhttps://string-db.org/network/9606.ENSP00000299687Zinc finger protein 407; May be involved in transcriptional regulation.
TK2 protein networkhttps://string-db.org/network/9606.ENSP00000299697Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulate [...]
A2ML1 protein networkhttps://string-db.org/network/9606.ENSP00000299698Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which conta [...]
TMED3 protein networkhttps://string-db.org/network/9606.ENSP00000299705Transmembrane emp24 domain-containing protein 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED1 [...]
SLC38A8 protein networkhttps://string-db.org/network/9606.ENSP00000299709Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family.
CPLX4 protein networkhttps://string-db.org/network/9606.ENSP00000299721Complexin-4; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By simil [...]
GALR1 protein networkhttps://string-db.org/network/9606.ENSP00000299727Galanin receptor type 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled recept [...]
CENPV protein networkhttps://string-db.org/network/9606.ENSP00000299736Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belong [...]
CDH16 protein networkhttps://string-db.org/network/9606.ENSP00000299752Cadherin-16; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
MC4R protein networkhttps://string-db.org/network/9606.ENSP00000299766Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic [...]
HSP90B1 protein networkhttps://string-db.org/network/9606.ENSP00000299767Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptor [...]
SLC9A5 protein networkhttps://string-db.org/network/9606.ENSP00000299798Sodium/hydrogen exchanger 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
NCAPH2 protein networkhttps://string-db.org/network/9606.ENSP00000299821Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishin [...]
PPP1R16B protein networkhttps://string-db.org/network/9606.ENSP00000299824Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in [...]
CHRFAM7A protein networkhttps://string-db.org/network/9606.ENSP00000299847CHRNA7-FAM7A fusion protein; CHRNA7 fusion.
POLR3E protein networkhttps://string-db.org/network/9606.ENSP00000299853DNA-directed RNA polymerase III subunit RPC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
MMP3 protein networkhttps://string-db.org/network/9606.ENSP00000299855Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase [...]
TVP23A protein networkhttps://string-db.org/network/9606.ENSP00000299866Trans-golgi network vesicle protein 23 homolog A; Belongs to the TVP23 family.
ZNF211 protein networkhttps://string-db.org/network/9606.ENSP00000299871Zinc finger protein 211; May be involved in transcriptional regulation.
TMPRSS5 protein networkhttps://string-db.org/network/9606.ENSP00000299882Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family.
COG1 protein networkhttps://string-db.org/network/9606.ENSP00000299886Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.
MARVELD3 protein networkhttps://string-db.org/network/9606.ENSP00000299952MARVEL domain containing 3.
CASC4 protein networkhttps://string-db.org/network/9606.ENSP00000299957Protein CASC4; Belongs to the GOLM1/CASC4 family.
SLFN5 protein networkhttps://string-db.org/network/9606.ENSP00000299977Schlafen family member 5; May have a role in hematopoietic cell differentiation. Belongs to the Schlafen family. Subgroup III subfamily.
BMERB1 protein networkhttps://string-db.org/network/9606.ENSP00000300006bMERB domain containing 1.
PPIB protein networkhttps://string-db.org/network/9606.ENSP00000300026Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding.
CIAO2A protein networkhttps://string-db.org/network/9606.ENSP00000300030Cytosolic iron-sulfur assembly component 2A; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster i [...]
PCLAF protein networkhttps://string-db.org/network/9606.ENSP00000300035PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interact [...]
LDHD protein networkhttps://string-db.org/network/9606.ENSP00000300051Probable D-lactate dehydrogenase, mitochondrial; Involved in D-lactate, but not L-lactate catabolic process. Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
PLIN1 protein networkhttps://string-db.org/network/9606.ENSP00000300055Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a ro [...]
PEX11A protein networkhttps://string-db.org/network/9606.ENSP00000300056Peroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By simi [...]
MESP1 protein networkhttps://string-db.org/network/9606.ENSP00000300057Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of th [...]
ANPEP protein networkhttps://string-db.org/network/9606.ENSP00000300060Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved i [...]
SCNN1G protein networkhttps://string-db.org/network/9606.ENSP00000300061Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...]
RBPMS2 protein networkhttps://string-db.org/network/9606.ENSP00000300069RNA-binding protein with multiple splicing 2; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA [...]
GLYATL1 protein networkhttps://string-db.org/network/9606.ENSP00000300079Glycine N-acyltransferase-like protein 1; Acyltransferase which transfers an acyl group to the N- terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. Belongs to the glycine N-acyltr [...]
TERF2IP protein networkhttps://string-db.org/network/9606.ENSP00000300086Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protecti [...]
DCTN5 protein networkhttps://string-db.org/network/9606.ENSP00000300087Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
PLK1 protein networkhttps://string-db.org/network/9606.ENSP00000300093Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome matura [...]
GPR182 protein networkhttps://string-db.org/network/9606.ENSP00000300098G-protein coupled receptor 182; Orphan receptor.
ZBTB39 protein networkhttps://string-db.org/network/9606.ENSP00000300101Zinc finger and BTB domain-containing protein 39; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CACNG2 protein networkhttps://string-db.org/network/9606.ENSP00000300105Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane a [...]
CLPX protein networkhttps://string-db.org/network/9606.ENSP00000300107ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradati [...]
CHP2 protein networkhttps://string-db.org/network/9606.ENSP00000300113Calcineurin B homologous protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in [...]
OR4D6 protein networkhttps://string-db.org/network/9606.ENSP00000300127Olfactory receptor 4D6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
NEMP1 protein networkhttps://string-db.org/network/9606.ENSP00000300128Nuclear envelope integral membrane protein 1.
NAB2 protein networkhttps://string-db.org/network/9606.ENSP00000300131NGFI-A-binding protein 2; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity); Belongs to the NAB family.
STAT6 protein networkhttps://string-db.org/network/9606.ENSP00000300134Signal transducer and activator of transcription 6; Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated [...]
ATP23 protein networkhttps://string-db.org/network/9606.ENSP00000300145Mitochondrial inner membrane protease ATP23 homolog; ATP23 metallopeptidase and ATP synthase assembly factor homolog.
PATL1 protein networkhttps://string-db.org/network/9606.ENSP00000300146Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and [...]
MRPL16 protein networkhttps://string-db.org/network/9606.ENSP00000300151Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family.
SCG5 protein networkhttps://string-db.org/network/9606.ENSP00000300175Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticul [...]
AGFG2 protein networkhttps://string-db.org/network/9606.ENSP00000300176Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2.
NYAP1 protein networkhttps://string-db.org/network/9606.ENSP00000300179Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesi [...]
TSC22D4 protein networkhttps://string-db.org/network/9606.ENSP00000300181TSC22 domain family protein 4; Transcriptional repressor.
MS4A6E protein networkhttps://string-db.org/network/9606.ENSP00000300182Membrane-spanning 4-domains subfamily A member 6E; May be involved in signal transduction as a component of a multimeric receptor complex.
MS4A7 protein networkhttps://string-db.org/network/9606.ENSP00000300184Membrane-spanning 4-domains subfamily A member 7; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
MS4A5 protein networkhttps://string-db.org/network/9606.ENSP00000300190Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex.
EEF1AKMT3 protein networkhttps://string-db.org/network/9606.ENSP00000300209EEF1A lysine methyltransferase 3; Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by [...]
CCNDBP1 protein networkhttps://string-db.org/network/9606.ENSP00000300213Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and b [...]
MS4A8 protein networkhttps://string-db.org/network/9606.ENSP00000300226Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex.
MAP1A protein networkhttps://string-db.org/network/9606.ENSP00000300231Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
AKTIP protein networkhttps://string-db.org/network/9606.ENSP00000300245AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sortin [...]
MAPRE2 protein networkhttps://string-db.org/network/9606.ENSP00000300249Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a [...]
EVA1C protein networkhttps://string-db.org/network/9606.ENSP00000300255Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family.
TCP10L protein networkhttps://string-db.org/network/9606.ENSP00000300258T-complex protein 10A homolog 1; May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.
CKMT1B protein networkhttps://string-db.org/network/9606.ENSP00000300283Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role [...]
PDIA3 protein networkhttps://string-db.org/network/9606.ENSP00000300289Protein disulfide-isomerase A3; Protein disulfide isomerase family A member 3; Belongs to the protein disulfide isomerase family.
NUDT21 protein networkhttps://string-db.org/network/9606.ENSP00000300291Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation pr [...]
NAT16 protein networkhttps://string-db.org/network/9606.ENSP00000300303Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of [...]
RUNX1 protein networkhttps://string-db.org/network/9606.ENSP00000300305Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the cor [...]
TPX2 protein networkhttps://string-db.org/network/9606.ENSP00000300403Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or [...]
B4GALNT2 protein networkhttps://string-db.org/network/9606.ENSP00000300404Beta-1,4 N-acetylgalactosaminyltransferase 2; Involved in the synthesis of the Sd(a) antigen (Sia-alpha2,3- [GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocyt [...]
SNRPD1 protein networkhttps://string-db.org/network/9606.ENSP00000300413Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, [...]
TMEM92 protein networkhttps://string-db.org/network/9606.ENSP00000300433Transmembrane protein 92.
COQ4 protein networkhttps://string-db.org/network/9606.ENSP00000300452Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzy [...]
SLC27A4 protein networkhttps://string-db.org/network/9606.ENSP00000300456Long-chain fatty acid transport protein 4; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intes [...]
TBC1D21 protein networkhttps://string-db.org/network/9606.ENSP00000300504TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possib [...]
COL6A2 protein networkhttps://string-db.org/network/9606.ENSP00000300527Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein.
PRR15L protein networkhttps://string-db.org/network/9606.ENSP00000300557Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family.
GPRC5B protein networkhttps://string-db.org/network/9606.ENSP00000300571G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein s [...]
CRK protein networkhttps://string-db.org/network/9606.ENSP00000300574Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent mann [...]
C16orf92 protein networkhttps://string-db.org/network/9606.ENSP00000300575Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92.
GOLGA6C protein networkhttps://string-db.org/network/9606.ENSP00000300576Golgin A6 family member C; Belongs to the GOLGA6 family.
TBC1D2B protein networkhttps://string-db.org/network/9606.ENSP00000300584TBC1 domain family member 2B; May act as a GTPase-activating protein.
NOD2 protein networkhttps://string-db.org/network/9606.ENSP00000300589Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds th [...]
HDHD2 protein networkhttps://string-db.org/network/9606.ENSP00000300605Haloacid dehalogenase like hydrolase domain containing 2.
ZNF91 protein networkhttps://string-db.org/network/9606.ENSP00000300619Zinc finger protein 91; Transcription factor specifically required to repress SINE- VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruitin [...]
GCN1 protein networkhttps://string-db.org/network/9606.ENSP00000300648eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating [...]
RNF214 protein networkhttps://string-db.org/network/9606.ENSP00000300650Ring finger protein 214.
MED1 protein networkhttps://string-db.org/network/9606.ENSP00000300651Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
PGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000300658Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 [...]
NFATC3 protein networkhttps://string-db.org/network/9606.ENSP00000300659Nuclear factor of activated T-cells, cytoplasmic 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the ind [...]
ATP5MG protein networkhttps://string-db.org/network/9606.ENSP00000300688ATP synthase subunit g, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...]
CD3D protein networkhttps://string-db.org/network/9606.ENSP00000300692T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cel [...]
RRM1 protein networkhttps://string-db.org/network/9606.ENSP00000300738Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
TRIM68 protein networkhttps://string-db.org/network/9606.ENSP00000300747E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
OR51B5 protein networkhttps://string-db.org/network/9606.ENSP00000300773Olfactory receptor 51B5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51Q1 protein networkhttps://string-db.org/network/9606.ENSP00000300778Olfactory receptor 51Q1; Odorant receptor.
FN3K protein networkhttps://string-db.org/network/9606.ENSP00000300784Fructosamine-3-kinase; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. [...]
ZNF428 protein networkhttps://string-db.org/network/9606.ENSP00000300811Zinc finger protein 428.
ZNF646 protein networkhttps://string-db.org/network/9606.ENSP00000300850Zinc finger protein 646; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF267 protein networkhttps://string-db.org/network/9606.ENSP00000300870Zinc finger protein 267; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GNG8 protein networkhttps://string-db.org/network/9606.ENSP00000300873Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
USP32 protein networkhttps://string-db.org/network/9606.ENSP00000300896Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family.
CA4 protein networkhttps://string-db.org/network/9606.ENSP00000300900Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload re [...]
RAB8A protein networkhttps://string-db.org/network/9606.ENSP00000300935Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
MIDN protein networkhttps://string-db.org/network/9606.ENSP00000300952Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin [...]
PCSK4 protein networkhttps://string-db.org/network/9606.ENSP00000300954Proprotein convertase subtilisin/kexin type 4; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (B [...]
JSRP1 protein networkhttps://string-db.org/network/9606.ENSP00000300961Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC [...]
KLHL26 protein networkhttps://string-db.org/network/9606.ENSP00000300976Kelch-like protein 26; Kelch like family member 26.
MVD protein networkhttps://string-db.org/network/9606.ENSP00000301012Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.
PIEZO1 protein networkhttps://string-db.org/network/9606.ENSP00000301015Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relations [...]
CDT1 protein networkhttps://string-db.org/network/9606.ENSP00000301019DNA replication factor Cdt1; Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre- replication complex assembly. Cooperates with CDC6 and the origin r [...]
ANKRD11 protein networkhttps://string-db.org/network/9606.ENSP00000301030Ankyrin repeat domain-containing protein 11; Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylase [...]
RSKR protein networkhttps://string-db.org/network/9606.ENSP00000301037Ribosomal protein S6 kinase related; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
PROCA1 protein networkhttps://string-db.org/network/9606.ENSP00000301039Protein interacting with cyclin A1; Belongs to the PROCA1 family.
LALBA protein networkhttps://string-db.org/network/9606.ENSP00000301046Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme [...]
CACNB3 protein networkhttps://string-db.org/network/9606.ENSP00000301050Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current [...]
TP53I13 protein networkhttps://string-db.org/network/9606.ENSP00000301057Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed.
WNT10B protein networkhttps://string-db.org/network/9606.ENSP00000301061Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and [...]
KMT2D protein networkhttps://string-db.org/network/9606.ENSP00000301067Histone-lysine N-methyltransferase 2D; Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a [...]
RHEBL1 protein networkhttps://string-db.org/network/9606.ENSP00000301068GTPase RhebL1; Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downst [...]
CYP2A6 protein networkhttps://string-db.org/network/9606.ENSP00000301141Cytochrome P450 2A6; Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation [...]
CYP2A7 protein networkhttps://string-db.org/network/9606.ENSP00000301146Cytochrome P450 2A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...]
GPD1 protein networkhttps://string-db.org/network/9606.ENSP00000301149Glycerol-3-phosphate dehydrogenase 1; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
LIN37 protein networkhttps://string-db.org/network/9606.ENSP00000301159Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component.
PRODH2 protein networkhttps://string-db.org/network/9606.ENSP00000301175Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can al [...]
AXL protein networkhttps://string-db.org/network/9606.ENSP00000301178Tyrosine-protein kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating [...]
DIP2B protein networkhttps://string-db.org/network/9606.ENSP00000301180Disco interacting protein 2 homolog B.
ANKRD33 protein networkhttps://string-db.org/network/9606.ENSP00000301190Photoreceptor ankyrin repeat protein; Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation.
CDC42EP5 protein networkhttps://string-db.org/network/9606.ENSP00000301200Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...]
LAIR2 protein networkhttps://string-db.org/network/9606.ENSP00000301202Leukocyte associated immunoglobulin like receptor 2.
TMEM145 protein networkhttps://string-db.org/network/9606.ENSP00000301204Transmembrane protein 145.
ZNF526 protein networkhttps://string-db.org/network/9606.ENSP00000301215Zinc finger protein 526; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GRIK5 protein networkhttps://string-db.org/network/9606.ENSP00000301218Glutamate receptor ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Gl [...]
PPP1R14A protein networkhttps://string-db.org/network/9606.ENSP00000301242Protein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylatio [...]
SPINT2 protein networkhttps://string-db.org/network/9606.ENSP00000301244Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
C19orf33 protein networkhttps://string-db.org/network/9606.ENSP00000301246Immortalization up-regulated protein; Chromosome 19 open reading frame 33.
PSCA protein networkhttps://string-db.org/network/9606.ENSP00000301258Prostate stem cell antigen; May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
LY6D protein networkhttps://string-db.org/network/9606.ENSP00000301263Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.
TMIGD2 protein networkhttps://string-db.org/network/9606.ENSP00000301272Transmembrane and immunoglobulin domain-containing protein 2; Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the [...]
CHAF1A protein networkhttps://string-db.org/network/9606.ENSP00000301280Chromatin assembly factor 1 subunit A; Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto repl [...]
UBXN6 protein networkhttps://string-db.org/network/9606.ENSP00000301281UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular proces [...]
NLRP4 protein networkhttps://string-db.org/network/9606.ENSP00000301295NACHT, LRR and PYD domains-containing protein 4; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound rece [...]
SLC39A4 protein networkhttps://string-db.org/network/9606.ENSP00000301305Zinc transporter ZIP4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).
ZNF582 protein networkhttps://string-db.org/network/9606.ENSP00000301310Zinc finger protein 582; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZFP28 protein networkhttps://string-db.org/network/9606.ENSP00000301318Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development.
MFSD3 protein networkhttps://string-db.org/network/9606.ENSP00000301327Major facilitator superfamily domain containing 3.
GLOD4 protein networkhttps://string-db.org/network/9606.ENSP00000301329Glyoxalase domain containing 4.
KIFC2 protein networkhttps://string-db.org/network/9606.ENSP00000301332Kinesin-like protein KIFC2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendr [...]
RILP protein networkhttps://string-db.org/network/9606.ENSP00000301336Rab-interacting lysosomal protein; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induce [...]
TSR1 protein networkhttps://string-db.org/network/9606.ENSP00000301364Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GT [...]
TRPV3 protein networkhttps://string-db.org/network/9606.ENSP00000301365Transient receptor potential cation channel subfamily V member 3; Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and s [...]
CYB5D2 protein networkhttps://string-db.org/network/9606.ENSP00000301391Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation.
PELP1 protein networkhttps://string-db.org/network/9606.ENSP00000301396Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcripti [...]
ZNF577 protein networkhttps://string-db.org/network/9606.ENSP00000301399Zinc finger protein 577; May be involved in transcriptional regulation.
CGB1 protein networkhttps://string-db.org/network/9606.ENSP00000301407Chorionic gonadotropin subunit beta 1.
CGB5 protein networkhttps://string-db.org/network/9606.ENSP00000301408Choriogonadotropin subunit beta 3; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalen [...]
KLK1 protein networkhttps://string-db.org/network/9606.ENSP00000301420Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily.
ACER1 protein networkhttps://string-db.org/network/9606.ENSP00000301452Alkaline ceramidase 1; Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphoryl [...]
SLC25A23 protein networkhttps://string-db.org/network/9606.ENSP00000301454Calcium-binding mitochondrial carrier protein SCaMC-3; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mi [...]
ANGPTL4 protein networkhttps://string-db.org/network/9606.ENSP00000301455Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabol [...]
NDUFA7 protein networkhttps://string-db.org/network/9606.ENSP00000301457NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
CD320 protein networkhttps://string-db.org/network/9606.ENSP00000301458CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (F [...]
RCOR2 protein networkhttps://string-db.org/network/9606.ENSP00000301459REST corepressor 2; May act as a component of a corepressor complex that represses transcription.
SPRYD3 protein networkhttps://string-db.org/network/9606.ENSP00000301463SPRY domain containing 3.
IGFBP6 protein networkhttps://string-db.org/network/9606.ENSP00000301464Insulin-like growth factor-binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...]
SOAT2 protein networkhttps://string-db.org/network/9606.ENSP00000301466Sterol O-acyltransferase 2; Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl e [...]
ZNF560 protein networkhttps://string-db.org/network/9606.ENSP00000301480Zinc finger protein 560; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CDK2AP2 protein networkhttps://string-db.org/network/9606.ENSP00000301488Cyclin-dependent kinase 2-associated protein 2; Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs [...]
PRDX2 protein networkhttps://string-db.org/network/9606.ENSP00000301522Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...]
OR5I1 protein networkhttps://string-db.org/network/9606.ENSP00000301532Olfactory receptor 5I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF443 protein networkhttps://string-db.org/network/9606.ENSP00000301547Zinc finger protein 443; May be involved in transcriptional regulation.
MRPL58 protein networkhttps://string-db.org/network/9606.ENSP00000301585Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that [...]
ATP5PD protein networkhttps://string-db.org/network/9606.ENSP00000301587ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...]
TMEM88 protein networkhttps://string-db.org/network/9606.ENSP00000301599Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commit [...]
BIRC5 protein networkhttps://string-db.org/network/9606.ENSP00000301633Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex ( [...]
CYP7A1 protein networkhttps://string-db.org/network/9606.ENSP00000301645Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inser [...]
KRT16 protein networkhttps://string-db.org/network/9606.ENSP00000301653Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some infl [...]
KRT27 protein networkhttps://string-db.org/network/9606.ENSP00000301656Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).
GSDMA protein networkhttps://string-db.org/network/9606.ENSP00000301659Gasdermin-A; May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidyl [...]
GHDC protein networkhttps://string-db.org/network/9606.ENSP00000301671GH3 domain-containing protein; GH3 domain containing.
SOST protein networkhttps://string-db.org/network/9606.ENSP00000301691Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
UNKL protein networkhttps://string-db.org/network/9606.ENSP00000301712Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other subst [...]
E4F1 protein networkhttps://string-db.org/network/9606.ENSP00000301727Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin- associated TP53. Functions in cell survival [...]
ECI1 protein networkhttps://string-db.org/network/9606.ENSP00000301729Enoyl-CoA delta isomerase 1, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species.
ABCA3 protein networkhttps://string-db.org/network/9606.ENSP00000301732ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter s [...]
KCTD5 protein networkhttps://string-db.org/network/9606.ENSP00000301738BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB [...]
SRRM2 protein networkhttps://string-db.org/network/9606.ENSP00000301740Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome. Belongs to the CWC21 family.
ZNF597 protein networkhttps://string-db.org/network/9606.ENSP00000301744Zinc finger protein 597; May be involved in transcriptional regulation.
SDHAF2 protein networkhttps://string-db.org/network/9606.ENSP00000301761Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...]
DDB1 protein networkhttps://string-db.org/network/9606.ENSP00000301764DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damag [...]
VPS37C protein networkhttps://string-db.org/network/9606.ENSP00000301765Vacuolar protein sorting-associated protein 37C; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...]
HNRNPUL2 protein networkhttps://string-db.org/network/9606.ENSP00000301785Heterogeneous nuclear ribonucleoprotein U like 2.
POLR2G protein networkhttps://string-db.org/network/9606.ENSP00000301788DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
PLAAT5 protein networkhttps://string-db.org/network/9606.ENSP00000301790Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent re [...]
ENTPD3 protein networkhttps://string-db.org/network/9606.ENSP00000301825Ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP.
ULK4 protein networkhttps://string-db.org/network/9606.ENSP00000301831Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as c [...]
FADD protein networkhttps://string-db.org/network/9606.ENSP00000301838FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-ind [...]
LTBP3 protein networkhttps://string-db.org/network/9606.ENSP00000301873Latent-transforming growth factor beta-binding protein 3; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent [...]
BATF2 protein networkhttps://string-db.org/network/9606.ENSP00000301887Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, par [...]
SLC22A11 protein networkhttps://string-db.org/network/9606.ENSP00000301891Solute carrier family 22 member 11; Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
MAJIN protein networkhttps://string-db.org/network/9606.ENSP00000301896Membrane anchored junction protein.
SCARA3 protein networkhttps://string-db.org/network/9606.ENSP00000301904Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
PNOC protein networkhttps://string-db.org/network/9606.ENSP00000301908Prepronociceptin; [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in ne [...]
GPR25 protein networkhttps://string-db.org/network/9606.ENSP00000301917Probable G-protein coupled receptor 25; Orphan receptor.
SOX7 protein networkhttps://string-db.org/network/9606.ENSP00000301921Transcription factor SOX-7; Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further diffe [...]
TRIM35 protein networkhttps://string-db.org/network/9606.ENSP00000301924Tripartite motif-containing protein 35; Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth. Involved in the [...]
TMEM256 protein networkhttps://string-db.org/network/9606.ENSP00000301939Transmembrane protein 256.
ANTXR1 protein networkhttps://string-db.org/network/9606.ENSP00000301945Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collage [...]
ACSM1 protein networkhttps://string-db.org/network/9606.ENSP00000301956Acyl-coenzyme A synthetase ACSM1, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain [...]
USP42 protein networkhttps://string-db.org/network/9606.ENSP00000301962Ubiquitin carboxyl-terminal hydrolase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis.
MYRIP protein networkhttps://string-db.org/network/9606.ENSP00000301972Rab effector MyRIP; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicl [...]
MFF protein networkhttps://string-db.org/network/9606.ENSP00000302037Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mito [...]
RNASE6 protein networkhttps://string-db.org/network/9606.ENSP00000302046Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram- negative bacteria, in [...]
ECEL1 protein networkhttps://string-db.org/network/9606.ENSP00000302051Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
C3AR1 protein networkhttps://string-db.org/network/9606.ENSP00000302079C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion p [...]
LGALS4 protein networkhttps://string-db.org/network/9606.ENSP00000302100Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
CRYGA protein networkhttps://string-db.org/network/9606.ENSP00000302105Gamma-crystallin A; Crystallins are the dominant structural components of the vertebrate eye lens.
PANK1 protein networkhttps://string-db.org/network/9606.ENSP00000302108Pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration; Belongs to the type II pantothenate kinase family.
MGMT protein networkhttps://string-db.org/network/9606.ENSP00000302111Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the [...]
PRELID1 protein networkhttps://string-db.org/network/9606.ENSP00000302114PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In [...]
TMEM154 protein networkhttps://string-db.org/network/9606.ENSP00000302144Transmembrane protein 154.
PRL protein networkhttps://string-db.org/network/9606.ENSP00000302150Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Belongs to the somatotropin/prolactin family.
LSM3 protein networkhttps://string-db.org/network/9606.ENSP00000302160U6 snRNA-associated Sm-like protein LSm3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
MBOAT2 protein networkhttps://string-db.org/network/9606.ENSP00000302177Lysophospholipid acyltransferase 2; Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1 [...]
NHLH1 protein networkhttps://string-db.org/network/9606.ENSP00000302189Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
ATP6V1G2 protein networkhttps://string-db.org/network/9606.ENSP00000302194V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...]
OR10V1 protein networkhttps://string-db.org/network/9606.ENSP00000302199Olfactory receptor 10V1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ATOH1 protein networkhttps://string-db.org/network/9606.ENSP00000302216Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator o [...]
ZNF25 protein networkhttps://string-db.org/network/9606.ENSP00000302222Zinc finger protein 25; May be involved in transcriptional regulation.
ALKBH3 protein networkhttps://string-db.org/network/9606.ENSP00000302232Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladeno [...]
CCL11 protein networkhttps://string-db.org/network/9606.ENSP00000302234Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
GBX2 protein networkhttps://string-db.org/network/9606.ENSP00000302251Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo.
VXN protein networkhttps://string-db.org/network/9606.ENSP00000302260Vexin; Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis.
C1QTNF4 protein networkhttps://string-db.org/network/9606.ENSP00000302274Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent. Seems t [...]
HEXIM2 protein networkhttps://string-db.org/network/9606.ENSP00000302276Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP com [...]
EMB protein networkhttps://string-db.org/network/9606.ENSP00000302289Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additio [...]
LGI3 protein networkhttps://string-db.org/network/9606.ENSP00000302297Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis.
PRY protein networkhttps://string-db.org/network/9606.ENSP00000302319PTPN13-like protein, Y-linked; PTPN13 like Y-linked.
RNASE3 protein networkhttps://string-db.org/network/9606.ENSP00000302324Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including [...]
PYGO1 protein networkhttps://string-db.org/network/9606.ENSP00000302327Pygopus homolog 1; Involved in signal transduction through the Wnt pathway.
LDHAL6B protein networkhttps://string-db.org/network/9606.ENSP00000302393Lactate dehydrogenase A like 6B.
TPST1 protein networkhttps://string-db.org/network/9606.ENSP00000302413Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the pr [...]
NANP protein networkhttps://string-db.org/network/9606.ENSP00000302441N-acylneuraminate-9-phosphatase; N-acetylneuraminic acid phosphatase.
ZNF17 protein networkhttps://string-db.org/network/9606.ENSP00000302455Zinc finger protein 17; May be involved in transcriptional regulation.
KLF13 protein networkhttps://string-db.org/network/9606.ENSP00000302456Krueppel-like factor 13; Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the [...]
HSPB2 protein networkhttps://string-db.org/network/9606.ENSP00000302476Heat shock protein beta-2; May regulate the kinase DMPK.
POLR1D protein networkhttps://string-db.org/network/9606.ENSP00000302478DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common co [...]
CSDC2 protein networkhttps://string-db.org/network/9606.ENSP00000302485Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might pla [...]
MAP2K1 protein networkhttps://string-db.org/network/9606.ENSP00000302486Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracel [...]
BUB1 protein networkhttps://string-db.org/network/9606.ENSP00000302530Mitotic checkpoint serine/threonine-protein kinase BUB1; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signalin [...]
MDM1 protein networkhttps://string-db.org/network/9606.ENSP00000302537Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules.
CXXC5 protein networkhttps://string-db.org/network/9606.ENSP00000302543CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity i [...]
HOXD4 protein networkhttps://string-db.org/network/9606.ENSP00000302548Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
GLOD5 protein networkhttps://string-db.org/network/9606.ENSP00000302552Glyoxalase domain containing 5; Belongs to the glyoxalase I family.
HSPBAP1 protein networkhttps://string-db.org/network/9606.ENSP00000302562HSPB1-associated protein 1; May play a role in cellular stress response.
CLEC7A protein networkhttps://string-db.org/network/9606.ENSP00000302569C-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta- 1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteri [...]
LRATD2 protein networkhttps://string-db.org/network/9606.ENSP00000302578Protein LRATD2; LRAT domain containing 2; Belongs to the LRATD family.
SCEL protein networkhttps://string-db.org/network/9606.ENSP00000302579Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sc [...]
KBTBD2 protein networkhttps://string-db.org/network/9606.ENSP00000302586Kelch repeat and BTB domain containing 2.
FUT9 protein networkhttps://string-db.org/network/9606.ENSP000003025994-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal [...]
ZNF556 protein networkhttps://string-db.org/network/9606.ENSP00000302603Zinc finger protein 556; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
AGXT protein networkhttps://string-db.org/network/9606.ENSP00000302620Alanine--glyoxylate and serine--pyruvate aminotransferase.
LRG1 protein networkhttps://string-db.org/network/9606.ENSP00000302621Leucine rich alpha-2-glycoprotein 1.
AXIN2 protein networkhttps://string-db.org/network/9606.ENSP00000302625Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
CHSY3 protein networkhttps://string-db.org/network/9606.ENSP00000302629Chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...]
ONECUT1 protein networkhttps://string-db.org/network/9606.ENSP00000302630Hepatocyte nuclear factor 6; Transcriptional activator. Binds the consensus sequence 5'- DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes [...]
UBTF protein networkhttps://string-db.org/network/9606.ENSP00000302640Nucleolar transcription factor 1; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription facto [...]
NRTN protein networkhttps://string-db.org/network/9606.ENSP00000302648Neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopo [...]
ABHD15 protein networkhttps://string-db.org/network/9606.ENSP00000302657Protein ABHD15; Abhydrolase domain containing 15.
GPR22 protein networkhttps://string-db.org/network/9606.ENSP00000302676G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway. May be involved in ciliogenesis (By similarity).
MUC17 protein networkhttps://string-db.org/network/9606.ENSP00000302716Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces.
KCNAB3 protein networkhttps://string-db.org/network/9606.ENSP00000302719Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.
INSL5 protein networkhttps://string-db.org/network/9606.ENSP00000302724Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for thi [...]
GUSB protein networkhttps://string-db.org/network/9606.ENSP00000302728Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.
FOXD4L1 protein networkhttps://string-db.org/network/9606.ENSP00000302756Forkhead box D4 like 1.
PAIP1 protein networkhttps://string-db.org/network/9606.ENSP00000302768Polyadenylate-binding protein-interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is medi [...]
ZNF296 protein networkhttps://string-db.org/network/9606.ENSP00000302770Zinc finger protein 296; May be a transcriptional corepressor with KLF4.
TRAPPC1 protein networkhttps://string-db.org/network/9606.ENSP00000302783Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily.
XPO6 protein networkhttps://string-db.org/network/9606.ENSP00000302790Exportin-6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
TRMT61B protein networkhttps://string-db.org/network/9606.ENSP00000302801tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including [...]
DDI1 protein networkhttps://string-db.org/network/9606.ENSP00000302805Protein DDI1 homolog 1; Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with [...]
MTNR1A protein networkhttps://string-db.org/network/9606.ENSP00000302811Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis tox [...]
OTP protein networkhttps://string-db.org/network/9606.ENSP00000302814Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells.
MAEA protein networkhttps://string-db.org/network/9606.ENSP00000302830E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent prot [...]
GIMAP1 protein networkhttps://string-db.org/network/9606.ENSP00000302833GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity).
DNAJC18 protein networkhttps://string-db.org/network/9606.ENSP00000302843DnaJ heat shock protein family member C18.
PTGER4 protein networkhttps://string-db.org/network/9606.ENSP00000302846Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on [...]
SLC23A1 protein networkhttps://string-db.org/network/9606.ENSP00000302851Solute carrier family 23 member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate; Belongs to the xanthine/uracil pe [...]
ZNF280A protein networkhttps://string-db.org/network/9606.ENSP00000302855Zinc finger protein 280A; May function as a transcription factor.
OR1L3 protein networkhttps://string-db.org/network/9606.ENSP00000302863Olfactory receptor 1L3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR7G3 protein networkhttps://string-db.org/network/9606.ENSP00000302867Olfactory receptor 7G3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PA2G4 protein networkhttps://string-db.org/network/9606.ENSP00000302886Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) an [...]
ARAP2 protein networkhttps://string-db.org/network/9606.ENSP00000302895Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodel [...]
AURKC protein networkhttps://string-db.org/network/9606.ENSP00000302898Aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions a [...]
SH3D19 protein networkhttps://string-db.org/network/9606.ENSP00000302913SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced [...]
IL17D protein networkhttps://string-db.org/network/9606.ENSP00000302924Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells.
IL16 protein networkhttps://string-db.org/network/9606.ENSP00000302935Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyt [...]
WFDC13 protein networkhttps://string-db.org/network/9606.ENSP00000302938WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
HSPA4 protein networkhttps://string-db.org/network/9606.ENSP00000302961Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.
HDAC3 protein networkhttps://string-db.org/network/9606.ENSP00000302967Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deace [...]
CDY1 protein networkhttps://string-db.org/network/9606.ENSP00000302968Testis-specific chromodomain protein Y 1; Has histone acetyltransferase activity, with a preference for histone H4.
SPRY3 protein networkhttps://string-db.org/network/9606.ENSP00000302978Protein sprouty homolog 3; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family.
ZRSR2 protein networkhttps://string-db.org/network/9606.ENSP00000303015U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with t [...]
TM4SF20 protein networkhttps://string-db.org/network/9606.ENSP00000303028Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen sy [...]
AFAP1L2 protein networkhttps://string-db.org/network/9606.ENSP00000303042Actin filament-associated protein 1-like 2; May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
PPIC protein networkhttps://string-db.org/network/9606.ENSP00000303057Peptidyl-prolyl cis-trans isomerase C; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the [...]
CEP120 protein networkhttps://string-db.org/network/9606.ENSP00000303058Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nucl [...]
XAGE3 protein networkhttps://string-db.org/network/9606.ENSP00000303061X antigen family member 3.
SCGB1D1 protein networkhttps://string-db.org/network/9606.ENSP00000303070Secretoglobin family 1D member 1; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of [...]
GOT1L1 protein networkhttps://string-db.org/network/9606.ENSP00000303077Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1.
VSTM2A protein networkhttps://string-db.org/network/9606.ENSP00000303108V-set and transmembrane domain-containing protein 2A; Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of pre [...]
VAT1L protein networkhttps://string-db.org/network/9606.ENSP00000303129Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport 1 like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
TMED10 protein networkhttps://string-db.org/network/9606.ENSP00000303145Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side [...]
MAT2A protein networkhttps://string-db.org/network/9606.ENSP00000303147S-adenosylmethionine synthase isoform type-2; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: [...]
TMEM37 protein networkhttps://string-db.org/network/9606.ENSP00000303148Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By simila [...]
GPR27 protein networkhttps://string-db.org/network/9606.ENSP00000303149Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.
COL22A1 protein networkhttps://string-db.org/network/9606.ENSP00000303153Collagen alpha-1(XXII) chain; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
CCDC8 protein networkhttps://string-db.org/network/9606.ENSP00000303158Coiled-coil domain-containing protein 8; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates mic [...]
UGT1A6 protein networkhttps://string-db.org/network/9606.ENSP00000303174UDP-glucuronosyltransferase 1-6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity [...]
CDY1B protein networkhttps://string-db.org/network/9606.ENSP00000303178Chromodomain Y-linked 1B.
RGL1 protein networkhttps://string-db.org/network/9606.ENSP00000303192Ral guanine nucleotide dissociation stimulator-like 1; Probable guanine nucleotide exchange factor.
REG1B protein networkhttps://string-db.org/network/9606.ENSP00000303206Lithostathine-1-beta; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
PCSK9 protein networkhttps://string-db.org/network/9606.ENSP00000303208Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein rece [...]
ACHE protein networkhttps://string-db.org/network/9606.ENSP00000303211Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis. Belongs t [...]
MTCH2 protein networkhttps://string-db.org/network/9606.ENSP00000303222Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Belongs to the mitochondrial carrier (TC 2.A.29) family.
IL12A protein networkhttps://string-db.org/network/9606.ENSP00000303231Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the producti [...]
ACOT12 protein networkhttps://string-db.org/network/9606.ENSP00000303246Acetyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to r [...]
ZNF804A protein networkhttps://string-db.org/network/9606.ENSP00000303252Zinc finger protein 804A.
RNASE2 protein networkhttps://string-db.org/network/9606.ENSP00000303276Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for de [...]
PRY2 protein networkhttps://string-db.org/network/9606.ENSP00000303300PTPN13 like Y-linked 2.
JUNB protein networkhttps://string-db.org/network/9606.ENSP00000303315Transcription factor jun-B; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'; Belongs to the bZIP [...]
TACR3 protein networkhttps://string-db.org/network/9606.ENSP00000303325Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messeng [...]
DCXR protein networkhttps://string-db.org/network/9606.ENSP00000303356L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metab [...]
LMAN2 protein networkhttps://string-db.org/network/9606.ENSP00000303366Vesicular integral-membrane protein VIP36; Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high- mannose type glycans and may a [...]
H2AC8 protein networkhttps://string-db.org/network/9606.ENSP00000303373Histone H2A type 1-B/E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Hist [...]
HSPB3 protein networkhttps://string-db.org/network/9606.ENSP00000303394Heat shock protein beta-3; Inhibitor of actin polymerization.
MTBP protein networkhttps://string-db.org/network/9606.ENSP00000303398Mdm2-binding protein; Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2- dependent p53/TP53 homeostasis in unstressed c [...]
FNTA protein networkhttps://string-db.org/network/9606.ENSP00000303423Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfe [...]
PTGDR protein networkhttps://string-db.org/network/9606.ENSP00000303424Prostaglandin D2 receptor; Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of i [...]
PDS5A protein networkhttps://string-db.org/network/9606.ENSP00000303427Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chro [...]
USP38 protein networkhttps://string-db.org/network/9606.ENSP00000303434Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards 'Lys- 63'-linked ubiquitin chains; Belongs to the peptidase C19 family.
TSNARE1 protein networkhttps://string-db.org/network/9606.ENSP00000303437t-SNARE domain containing 1.
TRH protein networkhttps://string-db.org/network/9606.ENSP00000303452Pro-thyrotropin-releasing hormone; As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone syn [...]
ZCCHC4 protein networkhttps://string-db.org/network/9606.ENSP00000303468rRNA N6-adenosine-methyltransferase ZCCHC4; rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is require [...]
REEP4 protein networkhttps://string-db.org/network/9606.ENSP00000303482Receptor expression-enhancing protein 4; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from ch [...]
C5orf34 protein networkhttps://string-db.org/network/9606.ENSP00000303490Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34.
BCR protein networkhttps://string-db.org/network/9606.ENSP00000303507Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) [...]
FRMD3 protein networkhttps://string-db.org/network/9606.ENSP00000303508FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer.
PEX6 protein networkhttps://string-db.org/network/9606.ENSP00000303511Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase [...]
DUS1L protein networkhttps://string-db.org/network/9606.ENSP00000303515tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily.
TACR1 protein networkhttps://string-db.org/network/9606.ENSP00000303522Substance-P receptor; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger syste [...]
CBR4 protein networkhttps://string-db.org/network/9606.ENSP00000303525Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid bi [...]
DEFB4A protein networkhttps://string-db.org/network/9606.ENSP00000303532Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse [...]
ZNF138 protein networkhttps://string-db.org/network/9606.ENSP00000303533Zinc finger protein 138.
SCN1A protein networkhttps://string-db.org/network/9606.ENSP00000303540Sodium channel protein type 1 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
GPR82 protein networkhttps://string-db.org/network/9606.ENSP00000303549Probable G-protein coupled receptor 82; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
CYTL1 protein networkhttps://string-db.org/network/9606.ENSP00000303550Cytokine-like protein 1; Cytokine like 1.
ANKMY2 protein networkhttps://string-db.org/network/9606.ENSP00000303570Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia.
NUDT9 protein networkhttps://string-db.org/network/9606.ENSP00000303575ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
NKIRAS2 protein networkhttps://string-db.org/network/9606.ENSP00000303580NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (N [...]
N6AMT1 protein networkhttps://string-db.org/network/9606.ENSP00000303584Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylati [...]
HSFY1 protein networkhttps://string-db.org/network/9606.ENSP00000303599Heat shock transcription factor Y-linked 1; Belongs to the HSF family.
LRP8 protein networkhttps://string-db.org/network/9606.ENSP00000303634Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Ree [...]
NTSR2 protein networkhttps://string-db.org/network/9606.ENSP00000303686Neurotensin receptor type 2; Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
ZNF57 protein networkhttps://string-db.org/network/9606.ENSP00000303696Zinc finger protein 57; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CDC25A protein networkhttps://string-db.org/network/9606.ENSP00000303706M-phase inducer phosphatase 1; Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activit [...]
UBE2E1 protein networkhttps://string-db.org/network/9606.ENSP00000303709Ubiquitin-conjugating enzyme E2 E1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Me [...]
PPID protein networkhttps://string-db.org/network/9606.ENSP00000303754Peptidyl-prolyl cis-trans isomerase D; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act [...]
LUZP1 protein networkhttps://string-db.org/network/9606.ENSP00000303758Leucine zipper protein 1.
HTRA3 protein networkhttps://string-db.org/network/9606.ENSP00000303766Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits si [...]
AKNA protein networkhttps://string-db.org/network/9606.ENSP00000303769Microtubule organization protein AKNA; Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and ret [...]
PROKR1 protein networkhttps://string-db.org/network/9606.ENSP00000303775Prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinosit [...]
TEX13B protein networkhttps://string-db.org/network/9606.ENSP00000303777Testis-expressed protein 13B; Testis expressed 13B; Belongs to the TEX13 family.
OR7G2 protein networkhttps://string-db.org/network/9606.ENSP00000303822Olfactory receptor 7G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
INSR protein networkhttps://string-db.org/network/9606.ENSP00000303830Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, includ [...]
OR8I2 protein networkhttps://string-db.org/network/9606.ENSP00000303864Olfactory receptor 8I2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DCLK2 protein networkhttps://string-db.org/network/9606.ENSP00000303887Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-reg [...]
TWF2 protein networkhttps://string-db.org/network/9606.ENSP00000303908Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also [...]
ABR protein networkhttps://string-db.org/network/9606.ENSP00000303909Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activatin [...]
ZNF561 protein networkhttps://string-db.org/network/9606.ENSP00000303915Zinc finger protein 561; May be involved in transcriptional regulation.
MZB1 protein networkhttps://string-db.org/network/9606.ENSP00000303920Marginal zone B- and B1-cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular [...]
KIAA0232 protein networkhttps://string-db.org/network/9606.ENSP00000303928Uncharacterized protein KIAA0232; KIAA0232.
GP9 protein networkhttps://string-db.org/network/9606.ENSP00000303942Platelet glycoprotein IX; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces [...]
CTRB2 protein networkhttps://string-db.org/network/9606.ENSP00000303963Chymotrypsinogen B2; Belongs to the peptidase S1 family.
SYCE1 protein networkhttps://string-db.org/network/9606.ENSP00000303978Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...]
TMEM223 protein networkhttps://string-db.org/network/9606.ENSP00000303987Transmembrane protein 223.
TMEM43 protein networkhttps://string-db.org/network/9606.ENSP00000303992Transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the [...]
GTPBP2 protein networkhttps://string-db.org/network/9606.ENSP00000303997GTP binding protein 2.
FOXA3 protein networkhttps://string-db.org/network/9606.ENSP00000304004Hepatocyte nuclear factor 3-gamma; Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core [...]
STARD5 protein networkhttps://string-db.org/network/9606.ENSP00000304032StAR-related lipid transfer protein 5; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).
RNF139 protein networkhttps://string-db.org/network/9606.ENSP00000304051E3 ubiquitin-protein ligase RNF139; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I u [...]
C7orf33 protein networkhttps://string-db.org/network/9606.ENSP00000304071Uncharacterized protein C7orf33; Chromosome 7 open reading frame 33.
OR4K15 protein networkhttps://string-db.org/network/9606.ENSP00000304077Olfactory receptor 4K15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FAM83B protein networkhttps://string-db.org/network/9606.ENSP00000304078Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR s [...]
COPS6 protein networkhttps://string-db.org/network/9606.ENSP00000304102COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
FAM171B protein networkhttps://string-db.org/network/9606.ENSP00000304108Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family.
KCNG3 protein networkhttps://string-db.org/network/9606.ENSP00000304127Potassium voltage-gated channel subfamily G member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; this pr [...]
SCG2 protein networkhttps://string-db.org/network/9606.ENSP00000304133Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
RBMXL2 protein networkhttps://string-db.org/network/9606.ENSP00000304139RNA-binding motif protein, X-linked-like-2; RBMX like 2.
COPS9 protein networkhttps://string-db.org/network/9606.ENSP00000304147COP9 signalosome complex subunit 9; [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essenti [...]
OR8U1 protein networkhttps://string-db.org/network/9606.ENSP00000304188Olfactory receptor 8U1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PCNX1 protein networkhttps://string-db.org/network/9606.ENSP00000304192Pecanex-like protein 1; Pecanex 1; Belongs to the pecanex family.
HIPK3 protein networkhttps://string-db.org/network/9606.ENSP00000304226Homeodomain-interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to [...]
HINT1 protein networkhttps://string-db.org/network/9606.ENSP00000304229Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monopho [...]
PCDHA10 protein networkhttps://string-db.org/network/9606.ENSP00000304234Protocadherin alpha-10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
OR1L6 protein networkhttps://string-db.org/network/9606.ENSP00000304235Olfactory receptor 1L6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CDK5R2 protein networkhttps://string-db.org/network/9606.ENSP00000304250Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII.
ZNF33A protein networkhttps://string-db.org/network/9606.ENSP00000304268Zinc finger protein 33A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TM4SF1 protein networkhttps://string-db.org/network/9606.ENSP00000304277Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family.
RAC3 protein networkhttps://string-db.org/network/9606.ENSP00000304283Ras-related C3 botulinum toxin substrate 3; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of ef [...]
FOXI1 protein networkhttps://string-db.org/network/9606.ENSP00000304286Forkhead box protein I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH [...]
CHRNB1 protein networkhttps://string-db.org/network/9606.ENSP00000304290Acetylcholine receptor subunit beta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting chan [...]
ANKRD27 protein networkhttps://string-db.org/network/9606.ENSP00000304292Ankyrin repeat domain-containing protein 27; May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane [...]
COPRS protein networkhttps://string-db.org/network/9606.ENSP00000304327Coordinator of PRMT5 and differentiation stimulator; Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation [...]
GSX1 protein networkhttps://string-db.org/network/9606.ENSP00000304331GS homeobox 1; Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary developmen [...]
PYDC1 protein networkhttps://string-db.org/network/9606.ENSP00000304336Pyrin domain-containing protein 1; Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses [...]
POP7 protein networkhttps://string-db.org/network/9606.ENSP00000304353Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclea [...]
CCDC126 protein networkhttps://string-db.org/network/9606.ENSP00000304355Coiled-coil domain containing 126.
SMYD4 protein networkhttps://string-db.org/network/9606.ENSP00000304360SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily.
C1GALT1C1 protein networkhttps://string-db.org/network/9606.ENSP00000304364C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycop [...]
RAB24 protein networkhttps://string-db.org/network/9606.ENSP00000304376Ras-related protein Rab-24; May be involved in autophagy-related processes. Belongs to the small GTPase superfamily. Rab family.
COL3A1 protein networkhttps://string-db.org/network/9606.ENSP00000304408Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in [...]
C2orf68 protein networkhttps://string-db.org/network/9606.ENSP00000304410UPF0561 protein C2orf68; Chromosome 2 open reading frame 68.
OR2B2 protein networkhttps://string-db.org/network/9606.ENSP00000304419Olfactory receptor 2B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
KREMEN2 protein networkhttps://string-db.org/network/9606.ENSP00000304422Kremen protein 2; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb de [...]
SNX7 protein networkhttps://string-db.org/network/9606.ENSP00000304429Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
FAM189A2 protein networkhttps://string-db.org/network/9606.ENSP00000304435Protein FAM189A2; Family with sequence similarity 189 member A2.
KNDC1 protein networkhttps://string-db.org/network/9606.ENSP00000304437Kinase non-catalytic C-lobe domain-containing protein 1; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pa [...]
HAS3 protein networkhttps://string-db.org/network/9606.ENSP00000304440Hyaluronan synthase 3; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...]
THOP1 protein networkhttps://string-db.org/network/9606.ENSP00000304467Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor prote [...]
ADORA2B protein networkhttps://string-db.org/network/9606.ENSP00000304501Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
SIX2 protein networkhttps://string-db.org/network/9606.ENSP00000304502Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenc [...]
MPLKIP protein networkhttps://string-db.org/network/9606.ENSP00000304553M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
ANKS3 protein networkhttps://string-db.org/network/9606.ENSP00000304586Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney.
FASN protein networkhttps://string-db.org/network/9606.ENSP000003045923-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has [...]
ZNHIT1 protein networkhttps://string-db.org/network/9606.ENSP00000304593Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 withou [...]
MAGI3 protein networkhttps://string-db.org/network/9606.ENSP00000304604Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Co [...]
RETREG1 protein networkhttps://string-db.org/network/9606.ENSP00000304642Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and E [...]
CALML6 protein networkhttps://string-db.org/network/9606.ENSP00000304643Calmodulin-like protein 6; Calmodulin like 6; Belongs to the calmodulin family. Calglandulin subfamily.
CTNNA1 protein networkhttps://string-db.org/network/9606.ENSP00000304669Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and w [...]
RNFT1 protein networkhttps://string-db.org/network/9606.ENSP00000304670E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate [...]
ATOH8 protein networkhttps://string-db.org/network/9606.ENSP00000304676Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH [...]
THAP11 protein networkhttps://string-db.org/network/9606.ENSP00000304689THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor th [...]
MSANTD4 protein networkhttps://string-db.org/network/9606.ENSP00000304713Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils.
SPACA5B protein networkhttps://string-db.org/network/9606.ENSP00000304762Sperm acrosome associated 5B; Belongs to the glycosyl hydrolase 22 family.
P2RY1 protein networkhttps://string-db.org/network/9606.ENSP00000304767P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, [...]
ZNF467 protein networkhttps://string-db.org/network/9606.ENSP00000304769Zinc finger protein 467; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of s [...]
CES3 protein networkhttps://string-db.org/network/9606.ENSP00000304782Carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-pipe [...]
SLC26A5 protein networkhttps://string-db.org/network/9606.ENSP00000304783Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to- [...]
DTYMK protein networkhttps://string-db.org/network/9606.ENSP00000304802Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family.
UGT2B7 protein networkhttps://string-db.org/network/9606.ENSP00000304811UDP-glucuronosyltransferase 2B7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
CSN3 protein networkhttps://string-db.org/network/9606.ENSP00000304822Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family.
UGT1A1 protein networkhttps://string-db.org/network/9606.ENSP00000304845UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates [...]
NUDCD2 protein networkhttps://string-db.org/network/9606.ENSP00000304854NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
ATP6V1E2 protein networkhttps://string-db.org/network/9606.ENSP00000304891V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intrace [...]
IRS1 protein networkhttps://string-db.org/network/9606.ENSP00000304895Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins contain [...]
CD2BP2 protein networkhttps://string-db.org/network/9606.ENSP00000304903CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.
TXNDC2 protein networkhttps://string-db.org/network/9606.ENSP00000304908Thioredoxin domain-containing protein 2; Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulf [...]
IL13 protein networkhttps://string-db.org/network/9606.ENSP00000304915Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. [...]
LRRC28 protein networkhttps://string-db.org/network/9606.ENSP00000304923Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28.
PPDPFL protein networkhttps://string-db.org/network/9606.ENSP00000304926Pancreatic progenitor cell differentiation and proliferation factor like.
SOSTDC1 protein networkhttps://string-db.org/network/9606.ENSP00000304930Sclerostin domain-containing protein 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits T [...]
TCTN2 protein networkhttps://string-db.org/network/9606.ENSP00000304941Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between t [...]
ROBO4 protein networkhttps://string-db.org/network/9606.ENSP00000304945Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migr [...]
MN1 protein networkhttps://string-db.org/network/9606.ENSP00000304956Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate [...]
BFSP2 protein networkhttps://string-db.org/network/9606.ENSP00000304987Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA.
PSG8 protein networkhttps://string-db.org/network/9606.ENSP00000305005Pregnancy specific beta-1-glycoprotein 8.
OR2K2 protein networkhttps://string-db.org/network/9606.ENSP00000305055Olfactory receptor 2K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMEM192 protein networkhttps://string-db.org/network/9606.ENSP00000305069Transmembrane protein 192.
RFXANK protein networkhttps://string-db.org/network/9606.ENSP00000305071DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. R [...]
ZNF439 protein networkhttps://string-db.org/network/9606.ENSP00000305077Zinc finger protein 439; May be involved in transcriptional regulation.
C22orf15 protein networkhttps://string-db.org/network/9606.ENSP00000305096Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15.
GIMAP8 protein networkhttps://string-db.org/network/9606.ENSP00000305107GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections.
SOCS5 protein networkhttps://string-db.org/network/9606.ENSP00000305133Suppressor of cytokine signaling 5; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of [...]
MCRIP2 protein networkhttps://string-db.org/network/9606.ENSP00000305138MAPK regulated corepressor interacting protein 2; Belongs to the MCRIP family.
PWWP2A protein networkhttps://string-db.org/network/9606.ENSP00000305151PWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. [...]
TRIM56 protein networkhttps://string-db.org/network/9606.ENSP00000305161E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets [...]
HS1BP3 protein networkhttps://string-db.org/network/9606.ENSP00000305193HCLS1-binding protein 3; May be a modulator of IL-2 signaling.
CKAP2L protein networkhttps://string-db.org/network/9606.ENSP00000305204Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells.
UGT2B4 protein networkhttps://string-db.org/network/9606.ENSP00000305221UDP-glucuronosyltransferase 2B4; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on [...]
SRP9 protein networkhttps://string-db.org/network/9606.ENSP00000305230Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with [...]
IRX1 protein networkhttps://string-db.org/network/9606.ENSP00000305244Iroquois-class homeodomain protein IRX-1; Iroquois homeobox 1.
STX8 protein networkhttps://string-db.org/network/9606.ENSP00000305255Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER; Belongs to the syntaxin fami [...]
GNB2 protein networkhttps://string-db.org/network/9606.ENSP00000305260Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...]
KRT28 protein networkhttps://string-db.org/network/9606.ENSP00000305263Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).
NLGN2 protein networkhttps://string-db.org/network/9606.ENSP00000305288Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other [...]
SLC6A19 protein networkhttps://string-db.org/network/9606.ENSP00000305302Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This upta [...]
FSTL5 protein networkhttps://string-db.org/network/9606.ENSP00000305334Follistatin-related protein 5; Follistatin like 5.
SOX14 protein networkhttps://string-db.org/network/9606.ENSP00000305343Transcription factor SOX-14; Acts as a negative regulator of transcription.
ADRB2 protein networkhttps://string-db.org/network/9606.ENSP00000305372Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epin [...]
ZNF440 protein networkhttps://string-db.org/network/9606.ENSP00000305373Zinc finger protein 440; May be involved in transcriptional regulation.
OR5T3 protein networkhttps://string-db.org/network/9606.ENSP00000305403Olfactory receptor 5T3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
S1PR1 protein networkhttps://string-db.org/network/9606.ENSP00000305416Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G prot [...]
CEBPB protein networkhttps://string-db.org/network/9606.ENSP00000305422CCAAT/enhancer-binding protein beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis [...]
OR1F1 protein networkhttps://string-db.org/network/9606.ENSP00000305424Olfactory receptor 1F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TUB protein networkhttps://string-db.org/network/9606.ENSP00000305426Tubby protein homolog; Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitr [...]
COG7 protein networkhttps://string-db.org/network/9606.ENSP00000305442Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function.
CNNM3 protein networkhttps://string-db.org/network/9606.ENSP00000305449Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family.
PDILT protein networkhttps://string-db.org/network/9606.ENSP00000305465Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis; Belongs to the protein disulfide isomerase family.
OR1S2 protein networkhttps://string-db.org/network/9606.ENSP00000305469Olfactory receptor 1S2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FEN1 protein networkhttps://string-db.org/network/9606.ENSP00000305480Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhan [...]
SPATA5L1 protein networkhttps://string-db.org/network/9606.ENSP00000305494Spermatogenesis-associated protein 5-like protein 1; Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. AFG2 subfamily.
SIRPG protein networkhttps://string-db.org/network/9606.ENSP00000305529Signal-regulatory protein gamma; Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells r [...]
THAP9 protein networkhttps://string-db.org/network/9606.ENSP00000305533DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition.
PCBP1 protein networkhttps://string-db.org/network/9606.ENSP00000305556Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replica [...]
B3GNT2 protein networkhttps://string-db.org/network/9606.ENSP00000305595N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elon [...]
FAM71B protein networkhttps://string-db.org/network/9606.ENSP00000305596Protein FAM71B; May be involved in RNA biogenesis.
FUT3 protein networkhttps://string-db.org/network/9606.ENSP00000305603Galactoside 3(4)-L-fucosyltransferase; May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. [...]
CPLX1 protein networkhttps://string-db.org/network/9606.ENSP00000305613Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigza [...]
NXNL1 protein networkhttps://string-db.org/network/9606.ENSP00000305631Nucleoredoxin-like protein 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods. Belongs to the nucleoredoxin family.
HOMER2 protein networkhttps://string-db.org/network/9606.ENSP00000305632Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...]
VAMP5 protein networkhttps://string-db.org/network/9606.ENSP00000305647Vesicle-associated membrane protein 5; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
CXCL10 protein networkhttps://string-db.org/network/9606.ENSP00000305651C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of c [...]
LETM1 protein networkhttps://string-db.org/network/9606.ENSP00000305653Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochond [...]
TVP23B protein networkhttps://string-db.org/network/9606.ENSP00000305654Trans-golgi network vesicle protein 23 homolog B; Belongs to the TVP23 family.
CAVIN2 protein networkhttps://string-db.org/network/9606.ENSP00000305675Caveolae-associated protein 2; Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola [...]
MRPL39 protein networkhttps://string-db.org/network/9606.ENSP00000305682Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family.
DERPC protein networkhttps://string-db.org/network/9606.ENSP00000305687Decreased expression in renal and prostate cancer protein; Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed; Belongs to the DERPC family.
GAA protein networkhttps://string-db.org/network/9606.ENSP0000030569270 kDa lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked g [...]
RBFA protein networkhttps://string-db.org/network/9606.ENSP00000305696Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A.
HOOK3 protein networkhttps://string-db.org/network/9606.ENSP00000305699Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). [...]
KCTD19 protein networkhttps://string-db.org/network/9606.ENSP00000305702BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain containing 19.
BMP1 protein networkhttps://string-db.org/network/9606.ENSP00000305714Bone morphogenetic protein 1; Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early develo [...]
IBTK protein networkhttps://string-db.org/network/9606.ENSP00000305721Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interferenc [...]
CHST11 protein networkhttps://string-db.org/network/9606.ENSP00000305725Carbohydrate sulfotransferase 11; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant pr [...]
CST1 protein networkhttps://string-db.org/network/9606.ENSP00000305731Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence [...]
LRTOMT protein networkhttps://string-db.org/network/9606.ENSP00000305742Transmembrane O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory funct [...]
MRGPRX1 protein networkhttps://string-db.org/network/9606.ENSP00000305766Mas-related G-protein coupled receptor member X1; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...]
SMAD1 protein networkhttps://string-db.org/network/9606.ENSP00000305769Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). SMAD1/OAZ [...]
SF3B3 protein networkhttps://string-db.org/network/9606.ENSP00000305790Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly [...]
STX18 protein networkhttps://string-db.org/network/9606.ENSP00000305810Syntaxin-18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
GPRIN1 protein networkhttps://string-db.org/network/9606.ENSP00000305839G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth.
SPACA5 protein networkhttps://string-db.org/network/9606.ENSP00000305847Sperm acrosome associated 5.
TM4SF4 protein networkhttps://string-db.org/network/9606.ENSP00000305852Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
SHLD1 protein networkhttps://string-db.org/network/9606.ENSP00000305875Shieldin complex subunit 1; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex f [...]
NMUR1 protein networkhttps://string-db.org/network/9606.ENSP00000305877Neuromedin-U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides.
TMEM208 protein networkhttps://string-db.org/network/9606.ENSP00000305892Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
KMT5B protein networkhttps://string-db.org/network/9606.ENSP00000305899Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce r [...]
UTF1 protein networkhttps://string-db.org/network/9606.ENSP00000305906Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2.
BRD3 protein networkhttps://string-db.org/network/9606.ENSP00000305918Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and in [...]
HTRA4 protein networkhttps://string-db.org/network/9606.ENSP00000305919Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family.
PPP4R4 protein networkhttps://string-db.org/network/9606.ENSP00000305924Serine/threonine-protein phosphatase 4 regulatory subunit 4; Putative regulatory subunit of serine/threonine-protein phosphatase 4.
OTUD7A protein networkhttps://string-db.org/network/9606.ENSP00000305926OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family.
USH2A protein networkhttps://string-db.org/network/9606.ENSP00000305941Usherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in dev [...]
OR4D5 protein networkhttps://string-db.org/network/9606.ENSP00000305970Olfactory receptor 4D5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SLCO1A2 protein networkhttps://string-db.org/network/9606.ENSP00000305974Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjug [...]
KRTAP1-1 protein networkhttps://string-db.org/network/9606.ENSP00000305975Keratin-associated protein 1-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
SIK2 protein networkhttps://string-db.org/network/9606.ENSP00000305976Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activi [...]
ALCAM protein networkhttps://string-db.org/network/9606.ENSP00000305988CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and pro [...]
PGK2 protein networkhttps://string-db.org/network/9606.ENSP00000305995Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family.
ATP5ME protein networkhttps://string-db.org/network/9606.ENSP00000306003ATP synthase subunit e, mitochondrial, N-terminally processed; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient [...]
ARF4 protein networkhttps://string-db.org/network/9606.ENSP00000306010ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may mo [...]
SYNPO2 protein networkhttps://string-db.org/network/9606.ENSP00000306015Synaptopodin-2; Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapt [...]
NUDT6 protein networkhttps://string-db.org/network/9606.ENSP00000306070Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation. Belongs to the Nudix hydrolase family.
MRM3 protein networkhttps://string-db.org/network/9606.ENSP00000306080rRNA methyltransferase 3, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S [...]
OR10H2 protein networkhttps://string-db.org/network/9606.ENSP00000306095Olfactory receptor 10H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FGB protein networkhttps://string-db.org/network/9606.ENSP00000306099Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fi [...]
PAM protein networkhttps://string-db.org/network/9606.ENSP00000306100Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive a [...]
CEP89 protein networkhttps://string-db.org/network/9606.ENSP00000306105Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity.
DDX19A protein networkhttps://string-db.org/network/9606.ENSP00000306117ATP-dependent RNA helicase DDX19A; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein par [...]
RPAP1 protein networkhttps://string-db.org/network/9606.ENSP00000306123RNA polymerase II-associated protein 1; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to r [...]
PRKCE protein networkhttps://string-db.org/network/9606.ENSP00000306124Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cell [...]
DRD5 protein networkhttps://string-db.org/network/9606.ENSP00000306129D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.
GRM5 protein networkhttps://string-db.org/network/9606.ENSP00000306138Metabotropic glutamate receptor 5; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
IL7R protein networkhttps://string-db.org/network/9606.ENSP00000306157Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP); Belongs to the type I cytokine receptor family. Type 4 subfamily [...]
ANKRD2 protein networkhttps://string-db.org/network/9606.ENSP00000306163Ankyrin repeat domain-containing protein 2; Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate [...]
ANTXR2 protein networkhttps://string-db.org/network/9606.ENSP00000306185Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family.
MMGT1 protein networkhttps://string-db.org/network/9606.ENSP00000306220Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family.
FOS protein networkhttps://string-db.org/network/9606.ENSP00000306245Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each [...]
ITPR1 protein networkhttps://string-db.org/network/9606.ENSP00000306253Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved i [...]
KRT78 protein networkhttps://string-db.org/network/9606.ENSP00000306261Keratin, type II cytoskeletal 78; Keratin 78; Belongs to the intermediate filament family.
KCNK3 protein networkhttps://string-db.org/network/9606.ENSP00000306275Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of [...]
TPD52L1 protein networkhttps://string-db.org/network/9606.ENSP00000306285Tumor protein D53; TPD52 like 1.
GON7 protein networkhttps://string-db.org/network/9606.ENSP00000306320EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...]
PWWP2B protein networkhttps://string-db.org/network/9606.ENSP00000306324PWWP domain containing 2B.
SLC25A33 protein networkhttps://string-db.org/network/9606.ENSP00000306328Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deox [...]
YWHAG protein networkhttps://string-db.org/network/9606.ENSP0000030633014-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partn [...]
RFX2 protein networkhttps://string-db.org/network/9606.ENSP00000306335DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such a [...]
CDKL2 protein networkhttps://string-db.org/network/9606.ENSP00000306340Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2.
TMEM135 protein networkhttps://string-db.org/network/9606.ENSP00000306344Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes D [...]
TBCA protein networkhttps://string-db.org/network/9606.ENSP00000306362Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
ZNF3 protein networkhttps://string-db.org/network/9606.ENSP00000306372Zinc finger protein 3; Involved in cell differentiation and/or proliferation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PRSS27 protein networkhttps://string-db.org/network/9606.ENSP00000306390Serine protease 27.
RNF187 protein networkhttps://string-db.org/network/9606.ENSP00000306396E3 ubiquitin-protein ligase RNF187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independe [...]
UQCRFS1 protein networkhttps://string-db.org/network/9606.ENSP00000306397Cytochrome b-c1 complex subunit Rieske, mitochondrial; [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembran [...]
ARMC4 protein networkhttps://string-db.org/network/9606.ENSP00000306410Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly.
CHCHD7 protein networkhttps://string-db.org/network/9606.ENSP00000306425Coiled-coil-helix-coiled-coil-helix domain containing 7; Belongs to the CHCHD7 family.
GPR37 protein networkhttps://string-db.org/network/9606.ENSP00000306449Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G- [...]
B4GALT6 protein networkhttps://string-db.org/network/9606.ENSP00000306459Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point [...]
SPRR1B protein networkhttps://string-db.org/network/9606.ENSP00000306461Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transg [...]
SHCBP1 protein networkhttps://string-db.org/network/9606.ENSP00000306473SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstre [...]
CHRM1 protein networkhttps://string-db.org/network/9606.ENSP00000306490Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...]
RAB33B protein networkhttps://string-db.org/network/9606.ENSP00000306496Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagoso [...]
KCNJ4 protein networkhttps://string-db.org/network/9606.ENSP00000306497Inward rectifier potassium channel 4; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dep [...]
CXCL8 protein networkhttps://string-db.org/network/9606.ENSP00000306512Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell ty [...]
CAMTA1 protein networkhttps://string-db.org/network/9606.ENSP00000306522Calmodulin-binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor. Belongs to the CAMTA family.
INSM2 protein networkhttps://string-db.org/network/9606.ENSP00000306523Insulinoma-associated protein 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.
DESI2 protein networkhttps://string-db.org/network/9606.ENSP00000306528Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabiliz [...]
MRPL13 protein networkhttps://string-db.org/network/9606.ENSP00000306548Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family.
HSFY2 protein networkhttps://string-db.org/network/9606.ENSP00000306549Heat shock transcription factor Y-linked 2.
OGG1 protein networkhttps://string-db.org/network/9606.ENSP00000306561DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) [...]
TMEM42 protein networkhttps://string-db.org/network/9606.ENSP00000306564Transmembrane protein 42.
ISG20 protein networkhttps://string-db.org/network/9606.ENSP00000306565Interferon-stimulated gene 20 kDa protein; Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antivira [...]
ADH1B protein networkhttps://string-db.org/network/9606.ENSP00000306606All-trans-retinol dehydrogenase [NAD(+)] ADH1B; Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate to retinoid m [...]
PPIH protein networkhttps://string-db.org/network/9606.ENSP00000306614Peptidyl-prolyl cis-trans isomerase H; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in [...]
ASPSCR1 protein networkhttps://string-db.org/network/9606.ENSP00000306625Tether containing UBX domain for GLUT4; Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at [...]
SLC9C1 protein networkhttps://string-db.org/network/9606.ENSP00000306627Sodium/hydrogen exchanger 10; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hy [...]
RGPD8 protein networkhttps://string-db.org/network/9606.ENSP00000306637RANBP2 like and GRIP domain containing 8.
ADRA1B protein networkhttps://string-db.org/network/9606.ENSP00000306662Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect i [...]
NUDT16L1 protein networkhttps://string-db.org/network/9606.ENSP00000306670Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem T [...]
ANKK1 protein networkhttps://string-db.org/network/9606.ENSP00000306678Ankyrin repeat and kinase domain containing 1.
PPM1D protein networkhttps://string-db.org/network/9606.ENSP00000306682Protein phosphatase 1D; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-1 [...]
BOLA2B protein networkhttps://string-db.org/network/9606.ENSP00000306752BolA-like protein 2; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothi [...]
NEUROD2 protein networkhttps://string-db.org/network/9606.ENSP00000306754Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. C [...]
ZNF584 protein networkhttps://string-db.org/network/9606.ENSP00000306756Zinc finger protein 584; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
LRRC45 protein networkhttps://string-db.org/network/9606.ENSP00000306760Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
LDB2 protein networkhttps://string-db.org/network/9606.ENSP00000306772LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
CCDC110 protein networkhttps://string-db.org/network/9606.ENSP00000306776Coiled-coil domain containing 110.
ARL6IP1 protein networkhttps://string-db.org/network/9606.ENSP00000306788ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent [...]
RBKS protein networkhttps://string-db.org/network/9606.ENSP00000306817Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histi [...]
AVEN protein networkhttps://string-db.org/network/9606.ENSP00000306822Cell death regulator Aven; Protects against apoptosis mediated by Apaf-1.
SEMA4C protein networkhttps://string-db.org/network/9606.ENSP00000306844Semaphorin-4C; Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-124 [...]
VASN protein networkhttps://string-db.org/network/9606.ENSP00000306864Vasorin; May act as an inhibitor of TGF-beta signaling.
GABARAP protein networkhttps://string-db.org/network/9606.ENSP00000306866Gamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved [...]
SEC23A protein networkhttps://string-db.org/network/9606.ENSP00000306881Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
CXCL11 protein networkhttps://string-db.org/network/9606.ENSP00000306884C-X-C motif chemokine 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May p [...]
TMEM126A protein networkhttps://string-db.org/network/9606.ENSP00000306887Transmembrane protein 126A; Belongs to the TMEM126 family.
FAM151A protein networkhttps://string-db.org/network/9606.ENSP00000306888Protein FAM151A; Family with sequence similarity 151 member A; Belongs to the FAM151 family.
ETV5 protein networkhttps://string-db.org/network/9606.ENSP00000306894ETS translocation variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'; Belongs to the ETS family.
PRND protein networkhttps://string-db.org/network/9606.ENSP00000306900Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+) ; Belongs to the prion family.
MRPL4 protein networkhttps://string-db.org/network/9606.ENSP00000306902Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family.
RNF181 protein networkhttps://string-db.org/network/9606.ENSP00000306906E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...]
PCDHGC4 protein networkhttps://string-db.org/network/9606.ENSP00000306918Protocadherin gamma-C4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GLB1 protein networkhttps://string-db.org/network/9606.ENSP00000306920Beta-galactosidase; [Isoform 1]: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
CDCA7 protein networkhttps://string-db.org/network/9606.ENSP00000306968Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insuffici [...]
OR1N1 protein networkhttps://string-db.org/network/9606.ENSP00000306974Olfactory receptor 1N1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
YEATS2 protein networkhttps://string-db.org/network/9606.ENSP00000306983YEATS domain-containing protein 2; Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and bind [...]
HAS2 protein networkhttps://string-db.org/network/9606.ENSP00000306991Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...]
MYOZ2 protein networkhttps://string-db.org/network/9606.ENSP00000306997Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...]
ESCO2 protein networkhttps://string-db.org/network/9606.ENSP00000306999N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromati [...]
APLF protein networkhttps://string-db.org/network/9606.ENSP00000307004Aprataxin and PNK-like factor; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post- [...]
IRX2 protein networkhttps://string-db.org/network/9606.ENSP00000307006Iroquois-class homeodomain protein IRX-2; Iroquois homeobox 2.
KRT73 protein networkhttps://string-db.org/network/9606.ENSP00000307014Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
KLF11 protein networkhttps://string-db.org/network/9606.ENSP00000307023Krueppel-like factor 11; Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like [...]
BNC1 protein networkhttps://string-db.org/network/9606.ENSP00000307041Zinc finger protein basonuclin-1; Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the ver [...]
SDC2 protein networkhttps://string-db.org/network/9606.ENSP00000307046Syndecan-2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).
KIF5B protein networkhttps://string-db.org/network/9606.ENSP00000307078Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells [...]
MAP6 protein networkhttps://string-db.org/network/9606.ENSP00000307093Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By si [...]
DEGS2 protein networkhttps://string-db.org/network/9606.ENSP00000307126Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.
C8orf74 protein networkhttps://string-db.org/network/9606.ENSP00000307129Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74.
CST5 protein networkhttps://string-db.org/network/9606.ENSP00000307132Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H [...]
CTNND2 protein networkhttps://string-db.org/network/9606.ENSP00000307134Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It pr [...]
TEX37 protein networkhttps://string-db.org/network/9606.ENSP00000307142Testis-expressed sequence 37 protein; Testis expressed 37.
DONSON protein networkhttps://string-db.org/network/9606.ENSP00000307143Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for [...]
RBMY1F protein networkhttps://string-db.org/network/9606.ENSP00000307155RNA binding motif protein Y-linked family 1 member F.
LAMB2 protein networkhttps://string-db.org/network/9606.ENSP00000307156Laminin subunit beta-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
OR8B12 protein networkhttps://string-db.org/network/9606.ENSP00000307159Olfactory receptor 8B12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PATE1 protein networkhttps://string-db.org/network/9606.ENSP00000307164Prostate and testis expressed 1; Belongs to the PATE family.
RAMAC protein networkhttps://string-db.org/network/9606.ENSP00000307181RNA guanine-N7 methyltransferase activating subunit; Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-c [...]
ING2 protein networkhttps://string-db.org/network/9606.ENSP00000307183Inhibitor of growth protein 2; Seems to be involved in p53/TP53 activation and p53/TP53- dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like co [...]
ASL protein networkhttps://string-db.org/network/9606.ENSP00000307188Argininosuccinate lyase.
DNAJB7 protein networkhttps://string-db.org/network/9606.ENSP00000307197DnaJ homolog subfamily B member 7; Probably acts as a co-chaperone.
AHSP protein networkhttps://string-db.org/network/9606.ENSP00000307199Alpha-hemoglobin-stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglo [...]
BPTF protein networkhttps://string-db.org/network/9606.ENSP00000307208Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcripti [...]
LCMT2 protein networkhttps://string-db.org/network/9606.ENSP00000307214tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modifie [...]
PCDHB1 protein networkhttps://string-db.org/network/9606.ENSP00000307234Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
EIF2AK3 protein networkhttps://string-db.org/network/9606.ENSP00000307235Eukaryotic translation initiation factor 2-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alph [...]
KRT74 protein networkhttps://string-db.org/network/9606.ENSP00000307240Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
PDHB protein networkhttps://string-db.org/network/9606.ENSP00000307241Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the gly [...]
AAMDC protein networkhttps://string-db.org/network/9606.ENSP00000307254Mth938 domain-containing protein; May play a role in preadipocyte differentiation and adipogenesis; Belongs to the AAMDC family.
P2RY12 protein networkhttps://string-db.org/network/9606.ENSP00000307259P2Y purinoceptor 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregati [...]
TBL2 protein networkhttps://string-db.org/network/9606.ENSP00000307260Transducin beta like 2.
C11orf24 protein networkhttps://string-db.org/network/9606.ENSP00000307264Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24.
IRF2BP1 protein networkhttps://string-db.org/network/9606.ENSP00000307265Interferon regulatory factor 2-binding protein 1; Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as a [...]
RPTOR protein networkhttps://string-db.org/network/9606.ENSP00000307272Regulatory-associated protein of mTOR; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response [...]
SCAMP3 protein networkhttps://string-db.org/network/9606.ENSP00000307275Secretory carrier-associated membrane protein 3; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family.
MYL1 protein networkhttps://string-db.org/network/9606.ENSP00000307280Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.
MCM7 protein networkhttps://string-db.org/network/9606.ENSP00000307288DNA replication licensing factor MCM7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
CAVIN3 protein networkhttps://string-db.org/network/9606.ENSP00000307292Caveolae-associated protein 3; Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth m [...]
CHST14 protein networkhttps://string-db.org/network/9606.ENSP00000307297Carbohydrate sulfotransferase 14; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0- [...]
FEM1B protein networkhttps://string-db.org/network/9606.ENSP00000307298Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associate [...]
DDIT4 protein networkhttps://string-db.org/network/9606.ENSP00000307305DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of [...]
HOXC10 protein networkhttps://string-db.org/network/9606.ENSP00000307321Homeobox protein Hox-C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
HCN1 protein networkhttps://string-db.org/network/9606.ENSP00000307342Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to [...]
SHE protein networkhttps://string-db.org/network/9606.ENSP00000307369SH2 domain-containing adapter protein E; Src homology 2 domain containing E.
MLLT10 protein networkhttps://string-db.org/network/9606.ENSP00000307411Protein AF-10; Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified [...]
MGAT2 protein networkhttps://string-db.org/network/9606.ENSP00000307423Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free te [...]
SLC22A25 protein networkhttps://string-db.org/network/9606.ENSP00000307443Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
NECAB2 protein networkhttps://string-db.org/network/9606.ENSP00000307449N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling effici [...]
MINAR1 protein networkhttps://string-db.org/network/9606.ENSP00000307461Major intrinsically disordered Notch2-binding receptor 1; Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR. N [...]
ARNT2 protein networkhttps://string-db.org/network/9606.ENSP00000307479Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal functio [...]
WDR48 protein networkhttps://string-db.org/network/9606.ENSP00000307491WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost in [...]
CALB2 protein networkhttps://string-db.org/network/9606.ENSP00000307508Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; Belongs to the calbindin family.
MRC2 protein networkhttps://string-db.org/network/9606.ENSP00000307513C-type mannose receptor 2; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release [...]
OR9G4 protein networkhttps://string-db.org/network/9606.ENSP00000307515Olfactory receptor 9G4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMPRSS11E protein networkhttps://string-db.org/network/9606.ENSP00000307519Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position.
CST2 protein networkhttps://string-db.org/network/9606.ENSP00000307540Cystatin-SA; Thiol protease inhibitor.
NPTX1 protein networkhttps://string-db.org/network/9606.ENSP00000307549Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitat [...]
QARS1 protein networkhttps://string-db.org/network/9606.ENSP00000307567Glutamine--tRNA ligase; Glutamine--tRNA ligase. Plays a critical role in brain development. Belongs to the class-I aminoacyl-tRNA synthetase family.
OR9K2 protein networkhttps://string-db.org/network/9606.ENSP00000307598Olfactory receptor 9K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZBTB5 protein networkhttps://string-db.org/network/9606.ENSP00000307604Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation.
AGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000307634Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP [...]
MORN4 protein networkhttps://string-db.org/network/9606.ENSP00000307636MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.
TTC36 protein networkhttps://string-db.org/network/9606.ENSP00000307640Tetratricopeptide repeat domain 36.
VPS50 protein networkhttps://string-db.org/network/9606.ENSP00000307666Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferri [...]
CANT1 protein networkhttps://string-db.org/network/9606.ENSP00000307674Soluble calcium-activated nucleotidase 1; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity [...]
TADA3 protein networkhttps://string-db.org/network/9606.ENSP00000307684Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be consid [...]
ACOX2 protein networkhttps://string-db.org/network/9606.ENSP00000307697Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Capable of oxidizing short as well as long chain 2-methyl bran [...]
TSPAN5 protein networkhttps://string-db.org/network/9606.ENSP00000307701Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Belongs to the tetraspanin (TM4SF) family.
H1-4 protein networkhttps://string-db.org/network/9606.ENSP00000307705Histone H1.4; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...]
NSG2 protein networkhttps://string-db.org/network/9606.ENSP00000307722Neuronal vesicle trafficking associated 2.
OR2C1 protein networkhttps://string-db.org/network/9606.ENSP00000307726Olfactory receptor 2C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6Q1 protein networkhttps://string-db.org/network/9606.ENSP00000307734Olfactory receptor 6Q1; Odorant receptor.
CMTM8 protein networkhttps://string-db.org/network/9606.ENSP00000307741CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family.
ZNF608 protein networkhttps://string-db.org/network/9606.ENSP00000307746Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription.
HTR1E protein networkhttps://string-db.org/network/9606.ENSP000003077665-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding cau [...]
ZNF239 protein networkhttps://string-db.org/network/9606.ENSP00000307774Zinc finger protein 239; May be involved in transcriptional regulation.
CYCS protein networkhttps://string-db.org/network/9606.ENSP00000307786Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrom [...]
ZPLD1 protein networkhttps://string-db.org/network/9606.ENSP00000307801Zona pellucida-like domain-containing protein 1, secreted form; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.
NPFFR2 protein networkhttps://string-db.org/network/9606.ENSP00000307822Neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occu [...]
ADGRF3 protein networkhttps://string-db.org/network/9606.ENSP00000307831Adhesion G-protein coupled receptor F3; Orphan receptor.
FBXO22 protein networkhttps://string-db.org/network/9606.ENSP00000307833F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric prot [...]
DRAP1 protein networkhttps://string-db.org/network/9606.ENSP00000307850Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction [...]
MUS81 protein networkhttps://string-db.org/network/9606.ENSP00000307853Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch [...]
PCMTD2 protein networkhttps://string-db.org/network/9606.ENSP00000307854protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family.
ZBTB4 protein networkhttps://string-db.org/network/9606.ENSP00000307858Zinc finger and BTB domain-containing protein 4; Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affi [...]
DIRC1 protein networkhttps://string-db.org/network/9606.ENSP00000307860Disrupted in renal carcinoma 1.
U2AF2 protein networkhttps://string-db.org/network/9606.ENSP00000307863Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-ter [...]
RPL13 protein networkhttps://string-db.org/network/9606.ENSP00000307889Ribosomal protein L13.
GLUL protein networkhttps://string-db.org/network/9606.ENSP00000307900Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates t [...]
CHST2 protein networkhttps://string-db.org/network/9606.ENSP00000307911Carbohydrate sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...]
GCC2 protein networkhttps://string-db.org/network/9606.ENSP00000307939GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the [...]
EEF2 protein networkhttps://string-db.org/network/9606.ENSP00000307940Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- [...]
HIGD2B protein networkhttps://string-db.org/network/9606.ENSP00000307951HIG1 hypoxia inducible domain family member 2B.
FAM174A protein networkhttps://string-db.org/network/9606.ENSP00000307954Membrane protein FAM174A; Family with sequence similarity 174 member A.
IQCF1 protein networkhttps://string-db.org/network/9606.ENSP00000307958IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction.
DST protein networkhttps://string-db.org/network/9606.ENSP00000307959Dystonin; Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the ac [...]
RFNG protein networkhttps://string-db.org/network/9606.ENSP00000307971Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of [...]
METTL18 protein networkhttps://string-db.org/network/9606.ENSP00000307975Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase; Belongs to the methyltransferase superfamily. METTL18 family.
TUT1 protein networkhttps://string-db.org/network/9606.ENSP00000308000Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates [...]
PABPC5 protein networkhttps://string-db.org/network/9606.ENSP00000308012Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than [...]
TADA2B protein networkhttps://string-db.org/network/9606.ENSP00000308022Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.
PCSK1 protein networkhttps://string-db.org/network/9606.ENSP00000308024Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephali [...]
CYP2S1 protein networkhttps://string-db.org/network/9606.ENSP00000308032Cytochrome P450 2S1; A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans- retinoic acid. [...]
OR10P1 protein networkhttps://string-db.org/network/9606.ENSP00000308082Olfactory receptor 10P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CD248 protein networkhttps://string-db.org/network/9606.ENSP00000308117Endosialin; May play a role in tumor angiogenesis.
ATP6V0A4 protein networkhttps://string-db.org/network/9606.ENSP00000308122V-type proton ATPase 116 kDa subunit a isoform 4; Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney.
AMZ1 protein networkhttps://string-db.org/network/9606.ENSP00000308149Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2. Belongs to the peptidase M54 family.
WDR3 protein networkhttps://string-db.org/network/9606.ENSP00000308179WD repeat domain 3; Belongs to the WD repeat WDR3/UTP12 family.
RNASEH2C protein networkhttps://string-db.org/network/9606.ENSP00000308193Ribonuclease H2 subunit C; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the rem [...]
MMP14 protein networkhttps://string-db.org/network/9606.ENSP00000308208Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and [...]
RGMB protein networkhttps://string-db.org/network/9606.ENSP00000308219RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogeneti [...]
COMMD1 protein networkhttps://string-db.org/network/9606.ENSP00000308236COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitinatio [...]
PTDSS2 protein networkhttps://string-db.org/network/9606.ENSP00000308258Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is spe [...]
MRPL38 protein networkhttps://string-db.org/network/9606.ENSP00000308275Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
C9orf131 protein networkhttps://string-db.org/network/9606.ENSP00000308279Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131.
FAM170B protein networkhttps://string-db.org/network/9606.ENSP00000308292Protein FAM170B; Plays a role in fertilization through the acrosome reaction. Belongs to the FAM170 family.
PPP1R3B protein networkhttps://string-db.org/network/9606.ENSP00000308318Protein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its [...]
UTP23 protein networkhttps://string-db.org/network/9606.ENSP00000308332rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily.
SEC16B protein networkhttps://string-db.org/network/9606.ENSP00000308339Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory c [...]
MLKL protein networkhttps://string-db.org/network/9606.ENSP00000308351Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to [...]
TIGD3 protein networkhttps://string-db.org/network/9606.ENSP00000308354Tigger transposable element derived 3.
P2RY14 protein networkhttps://string-db.org/network/9606.ENSP00000308361P2Y purinoceptor 14; Receptor for UDP-glucose and other UDP-sugar coupled to G- proteins. Not activated by ATP, ADP, UTP or ATP.
LEMD3 protein networkhttps://string-db.org/network/9606.ENSP00000308369Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced ce [...]
H2AZ2 protein networkhttps://string-db.org/network/9606.ENSP00000308405Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machiner [...]
RPS6KB2 protein networkhttps://string-db.org/network/9606.ENSP00000308413Ribosomal protein S6 kinase beta-2; Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell prolife [...]
CYB5B protein networkhttps://string-db.org/network/9606.ENSP00000308430Cytochrome b5 type B; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
KRT17 protein networkhttps://string-db.org/network/9606.ENSP00000308452Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Re [...]
RND1 protein networkhttps://string-db.org/network/9606.ENSP00000308461Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac [...]
EIF4EBP3 protein networkhttps://string-db.org/network/9606.ENSP00000308472Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphoryla [...]
GPR171 protein networkhttps://string-db.org/network/9606.ENSP00000308479Probable G-protein coupled receptor 171; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
ARL10 protein networkhttps://string-db.org/network/9606.ENSP00000308496ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family.
GEMIN2 protein networkhttps://string-db.org/network/9606.ENSP00000308533Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...]
GOLT1A protein networkhttps://string-db.org/network/9606.ENSP00000308535Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family.
F2 protein networkhttps://string-db.org/network/9606.ENSP00000308541Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protei [...]
MEPCE protein networkhttps://string-db.org/network/9606.ENSP000003085467SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
ZNHIT2 protein networkhttps://string-db.org/network/9606.ENSP00000308548Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 [...]
RHOD protein networkhttps://string-db.org/network/9606.ENSP00000308576Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of ac [...]
ZNF431 protein networkhttps://string-db.org/network/9606.ENSP00000308578Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transc [...]
CENPS protein networkhttps://string-db.org/network/9606.ENSP00000308583Centromere protein S; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 comple [...]
GAL3ST3 protein networkhttps://string-db.org/network/9606.ENSP00000308591Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-Glc [...]
DLEC1 protein networkhttps://string-db.org/network/9606.ENSP00000308597Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation.
AGR3 protein networkhttps://string-db.org/network/9606.ENSP00000308606Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calci [...]
GPD2 protein networkhttps://string-db.org/network/9606.ENSP00000308610Glycerol-3-phosphate dehydrogenase, mitochondrial; Glycerol-3-phosphate dehydrogenase 2; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
GLE1 protein networkhttps://string-db.org/network/9606.ENSP00000308622Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear por [...]
OR10AD1 protein networkhttps://string-db.org/network/9606.ENSP00000308689Olfactory receptor 10AD1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DPY19L1 protein networkhttps://string-db.org/network/9606.ENSP00000308695Probable C-mannosyltransferase DPY19L1; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
INHBC protein networkhttps://string-db.org/network/9606.ENSP00000308716Inhibin beta C chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...]
MRPL48 protein networkhttps://string-db.org/network/9606.ENSP00000308717Mitochondrial ribosomal protein L48.
PRSS1 protein networkhttps://string-db.org/network/9606.ENSP00000308720Alpha-trypsin chain 1; Has activity against the synthetic substrates Boc-Phe-Ser- Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg- Mec. The single-chain form is more active [...]
GABRB3 protein networkhttps://string-db.org/network/9606.ENSP00000308725Gamma-aminobutyric acid receptor subunit beta-3; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. [...]
SUSD5 protein networkhttps://string-db.org/network/9606.ENSP00000308727Sushi domain containing 5.
GPR151 protein networkhttps://string-db.org/network/9606.ENSP00000308733G-protein coupled receptor 151; Proton-sensing G-protein coupled receptor.
CBX2 protein networkhttps://string-db.org/network/9606.ENSP00000308750Chromobox protein homolog 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
TMOD3 protein networkhttps://string-db.org/network/9606.ENSP00000308753Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...]
ZBTB21 protein networkhttps://string-db.org/network/9606.ENSP00000308759Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor.
OR52I2 protein networkhttps://string-db.org/network/9606.ENSP00000308764Olfactory receptor 52I2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SULT1B1 protein networkhttps://string-db.org/network/9606.ENSP00000308770Sulfotransferase family cytosolic 1B member 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurot [...]
ANKS4B protein networkhttps://string-db.org/network/9606.ENSP00000308772Ankyrin repeat and SAM domain-containing protein 4B; As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organiza [...]
GP6 protein networkhttps://string-db.org/network/9606.ENSP00000308782Platelet glycoprotein VI; Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin fo [...]
CCL19 protein networkhttps://string-db.org/network/9606.ENSP00000308815C-C motif chemokine 19; May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T [...]
RIC3 protein networkhttps://string-db.org/network/9606.ENSP00000308820Protein RIC-3; Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotonin [...]
CCDC74B protein networkhttps://string-db.org/network/9606.ENSP00000308873Coiled-coil domain containing 74B.
SNED1 protein networkhttps://string-db.org/network/9606.ENSP00000308893Sushi, nidogen and EGF like domains 1.
SLC19A1 protein networkhttps://string-db.org/network/9606.ENSP00000308895Reduced folate transporter; Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides. Has high affinity for N5-methyltetrahydrofolate, the predominant circulat [...]
MRPL11 protein networkhttps://string-db.org/network/9606.ENSP00000308897Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family.
GPR148 protein networkhttps://string-db.org/network/9606.ENSP00000308908Probable G-protein coupled receptor 148; Orphan receptor.
ZCCHC12 protein networkhttps://string-db.org/network/9606.ENSP00000308921Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMA [...]
TLR10 protein networkhttps://string-db.org/network/9606.ENSP00000308925Toll-like receptor 10; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [...]
PPM1J protein networkhttps://string-db.org/network/9606.ENSP00000308926Protein phosphatase, Mg2+/Mn2+ dependent 1J; Belongs to the PP2C family.
PMP22 protein networkhttps://string-db.org/network/9606.ENSP00000308937Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family.
PLG protein networkhttps://string-db.org/network/9606.ENSP00000308938Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, [...]
HLTF protein networkhttps://string-db.org/network/9606.ENSP00000308944Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for trans [...]
PSG1 protein networkhttps://string-db.org/network/9606.ENSP00000308970Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family.
VWC2L protein networkhttps://string-db.org/network/9606.ENSP00000308976Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization.
THAP6 protein networkhttps://string-db.org/network/9606.ENSP00000309007THAP domain containing 6.
VCPIP1 protein networkhttps://string-db.org/network/9606.ENSP00000309031Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitiona [...]
TSPAN17 protein networkhttps://string-db.org/network/9606.ENSP00000309036Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family.
CATSPER1 protein networkhttps://string-db.org/network/9606.ENSP00000309052Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...]
PLAC8L1 protein networkhttps://string-db.org/network/9606.ENSP00000309087PLAC8-like protein 1; PLAC8 like 1; Belongs to the cornifelin family.
GMPPB protein networkhttps://string-db.org/network/9606.ENSP00000309092Mannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Belongs to the transferase hexapept [...]
B4GAT1 protein networkhttps://string-db.org/network/9606.ENSP00000309096Beta-1,4-glucuronyltransferase 1; Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor [...]
PTPN7 protein networkhttps://string-db.org/network/9606.ENSP00000309116Tyrosine-protein phosphatase non-receptor type 7; Protein phosphatase that acts preferentially on tyrosine- phosphorylated MAPK1. Plays a role in the regulation of T and B- lymphocyte development [...]
OLR1 protein networkhttps://string-db.org/network/9606.ENSP00000309124Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascu [...]
NSUN5 protein networkhttps://string-db.org/network/9606.ENSP00000309126Probable 28S rRNA (cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA.
BCL2L14 protein networkhttps://string-db.org/network/9606.ENSP00000309132Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis.
MARCHF3 protein networkhttps://string-db.org/network/9606.ENSP00000309141E3 ubiquitin-protein ligase MARCHF3; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in t [...]
PDE12 protein networkhttps://string-db.org/network/9606.ENSP000003091422',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modula [...]
ZNF471 protein networkhttps://string-db.org/network/9606.ENSP00000309161Zinc finger protein 471; May be involved in transcriptional regulation.
RCE1 protein networkhttps://string-db.org/network/9606.ENSP00000309163CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K- Ras, N-Ras, H-Ras, RAP1B and G-gamma-1.
SH3RF3 protein networkhttps://string-db.org/network/9606.ENSP00000309186E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity.
CBY2 protein networkhttps://string-db.org/network/9606.ENSP00000309189Chibby family member 2.
UBE3C protein networkhttps://string-db.org/network/9606.ENSP00000309198Ubiquitin-protein ligase E3C; E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquit [...]
POMZP3 protein networkhttps://string-db.org/network/9606.ENSP00000309233POM121 and ZP3 fusion.
LRRC7 protein networkhttps://string-db.org/network/9606.ENSP00000309245Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N- [...]
USP48 protein networkhttps://string-db.org/network/9606.ENSP00000309262Ubiquitin carboxyl-terminal hydrolase 48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of [...]
CHST1 protein networkhttps://string-db.org/network/9606.ENSP00000309270Carbohydrate sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) resid [...]
CCDC96 protein networkhttps://string-db.org/network/9606.ENSP00000309285Coiled-coil domain containing 96.
ZNF680 protein networkhttps://string-db.org/network/9606.ENSP00000309330Zinc finger protein 680; May be involved in transcriptional regulation.
RPL15 protein networkhttps://string-db.org/network/9606.ENSP00000309334Ribosomal protein L15.
HOXC5 protein networkhttps://string-db.org/network/9606.ENSP00000309336Homeobox protein Hox-C5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
CLCF1 protein networkhttps://string-db.org/network/9606.ENSP00000309338Cardiotrophin-like cytokine factor 1; In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). Also stimulates B-cells. [...]
CD164 protein networkhttps://string-db.org/network/9606.ENSP00000309376Sialomucin core protein 24; Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell pr [...]
TRAM1L1 protein networkhttps://string-db.org/network/9606.ENSP00000309402Translocating chain-associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; Belongs to the TRAM family.
CLTB protein networkhttps://string-db.org/network/9606.ENSP00000309415Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.
ZDHHC24 protein networkhttps://string-db.org/network/9606.ENSP00000309429Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family.
PIGS protein networkhttps://string-db.org/network/9606.ENSP00000309430GPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates.
RETREG3 protein networkhttps://string-db.org/network/9606.ENSP00000309432Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth. Belongs to the RETREG family.
HOXB9 protein networkhttps://string-db.org/network/9606.ENSP00000309439Homeobox protein Hox-B9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
VPS41 protein networkhttps://string-db.org/network/9606.ENSP00000309457Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...]
LIPT2 protein networkhttps://string-db.org/network/9606.ENSP00000309463Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes [...]
PSMD1 protein networkhttps://string-db.org/network/9606.ENSP0000030947426S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
ACO1 protein networkhttps://string-db.org/network/9606.ENSP00000309477Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, seques [...]
GPRC6A protein networkhttps://string-db.org/network/9606.ENSP00000309493G-protein coupled receptor family C group 6 member A; Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar am [...]
NWD2 protein networkhttps://string-db.org/network/9606.ENSP00000309501NACHT and WD repeat domain containing 2.
SLC26A7 protein networkhttps://string-db.org/network/9606.ENSP00000309504Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the e [...]
PHYHD1 protein networkhttps://string-db.org/network/9606.ENSP00000309515Phytanoyl-CoA dioxygenase domain-containing protein 1; Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is no [...]
LIME1 protein networkhttps://string-db.org/network/9606.ENSP00000309521Lck-interacting transmembrane adapter 1; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence [...]
CSHL1 protein networkhttps://string-db.org/network/9606.ENSP00000309524Chorionic somatomammotropin hormone-like 1; May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.
DAPL1 protein networkhttps://string-db.org/network/9606.ENSP00000309538Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis.
PGA5 protein networkhttps://string-db.org/network/9606.ENSP00000309542Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
PDP2 protein networkhttps://string-db.org/network/9606.ENSP00000309548[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate [...]
HCFC1 protein networkhttps://string-db.org/network/9606.ENSP00000309555HCF C-terminal chain 1; Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its abilit [...]
UQCRH protein networkhttps://string-db.org/network/9606.ENSP00000309565Cytochrome b-c1 complex subunit 6, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport [...]
KLF7 protein networkhttps://string-db.org/network/9606.ENSP00000309570Krueppel-like factor 7; Transcriptional factor. Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation. [...]
TERT protein networkhttps://string-db.org/network/9606.ENSP00000309572Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, [...]
PRKACA protein networkhttps://string-db.org/network/9606.ENSP00000309591cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regu [...]
TWNK protein networkhttps://string-db.org/network/9606.ENSP00000309595Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime mai [...]
MAP3K11 protein networkhttps://string-db.org/network/9606.ENSP00000309597Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), [...]
ZNF408 protein networkhttps://string-db.org/network/9606.ENSP00000309606Zinc finger protein 408; May be involved in transcriptional regulation.
METTL2A protein networkhttps://string-db.org/network/9606.ENSP00000309610tRNA N(3)-methylcytidine methyltransferase METTL2A; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of [...]
XXYLT1 protein networkhttps://string-db.org/network/9606.ENSP00000309640Xyloside xylosyltransferase 1; Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins b [...]
BOD1 protein networkhttps://string-db.org/network/9606.ENSP00000309644Biorientation of chromosomes in cell division protein 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
GLIS1 protein networkhttps://string-db.org/network/9606.ENSP00000309653Zinc finger protein GLIS1; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involv [...]
OR52W1 protein networkhttps://string-db.org/network/9606.ENSP00000309673Olfactory receptor 52W1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LRCH4 protein networkhttps://string-db.org/network/9606.ENSP00000309689Leucine rich repeats and calponin homology domain containing 4.
SH3PXD2B protein networkhttps://string-db.org/network/9606.ENSP00000309714SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidas [...]
SLCO4C1 protein networkhttps://string-db.org/network/9606.ENSP00000309741Solute carrier organic anion transporter family member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAM [...]
APOBEC3F protein networkhttps://string-db.org/network/9606.ENSP00000309749DNA dC->dU-editing enzyme APOBEC-3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
SLC16A13 protein networkhttps://string-db.org/network/9606.ENSP00000309751Monocarboxylate transporter 13; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
NLRP6 protein networkhttps://string-db.org/network/9606.ENSP00000309767NACHT, LRR and PYD domains-containing protein 6; As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...]
CPED1 protein networkhttps://string-db.org/network/9606.ENSP00000309772Cadherin like and PC-esterase domain containing 1.
MIS18BP1 protein networkhttps://string-db.org/network/9606.ENSP00000309790Mis18-binding protein 1; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
TMEM234 protein networkhttps://string-db.org/network/9606.ENSP00000309792Transmembrane protein 234; Belongs to the TMEM234 family.
TBC1D16 protein networkhttps://string-db.org/network/9606.ENSP00000309794TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s).
RPL38 protein networkhttps://string-db.org/network/9606.ENSP00000309830Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family.
CCDC13 protein networkhttps://string-db.org/network/9606.ENSP00000309836Coiled-coil domain-containing protein 13; Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia.
NARF protein networkhttps://string-db.org/network/9606.ENSP00000309899Nuclear prelamin A recognition factor; Belongs to the NARF family.
TBX5 protein networkhttps://string-db.org/network/9606.ENSP00000309913T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif [...]
SPNS1 protein networkhttps://string-db.org/network/9606.ENSP00000309945Protein spinster homolog 1; Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.
EFEMP2 protein networkhttps://string-db.org/network/9606.ENSP00000309953EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family.
ADAM17 protein networkhttps://string-db.org/network/9606.ENSP00000309968Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble [...]
CNIH2 protein networkhttps://string-db.org/network/9606.ENSP00000310003Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modula [...]
NR1D2 protein networkhttps://string-db.org/network/9606.ENSP00000310006Nuclear receptor subfamily 1 group D member 2; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex tr [...]
SWSAP1 protein networkhttps://string-db.org/network/9606.ENSP00000310008ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its AT [...]
ADAT1 protein networkhttps://string-db.org/network/9606.ENSP00000310015tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA-Ala.
CD34 protein networkhttps://string-db.org/network/9606.ENSP00000310036Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or dire [...]
ZNF622 protein networkhttps://string-db.org/network/9606.ENSP00000310042Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development.
FAM53A protein networkhttps://string-db.org/network/9606.ENSP00000310057Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle. Belongs to the FAM53 family.
TAOK2 protein networkhttps://string-db.org/network/9606.ENSP00000310094Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 M [...]
TMEM255A protein networkhttps://string-db.org/network/9606.ENSP00000310110Transmembrane protein 255A; Belongs to the TMEM255 family.
PPP1R14B protein networkhttps://string-db.org/network/9606.ENSP00000310117Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
ALG10B protein networkhttps://string-db.org/network/9606.ENSP00000310120Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide pre [...]
PSMD2 protein networkhttps://string-db.org/network/9606.ENSP0000031012926S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
CYP2W1 protein networkhttps://string-db.org/network/9606.ENSP00000310149Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of [...]
FOSL1 protein networkhttps://string-db.org/network/9606.ENSP00000310170Fos-related antigen 1; FOS like 1, AP-1 transcription factor subunit; Belongs to the bZIP family. Fos subfamily.
FAM241A protein networkhttps://string-db.org/network/9606.ENSP00000310182Uncharacterized protein FAM241A; Family with sequence similarity 241 member A.
NRIP3 protein networkhttps://string-db.org/network/9606.ENSP00000310205Nuclear receptor interacting protein 3.
SLC5A6 protein networkhttps://string-db.org/network/9606.ENSP00000310208Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
KLRC4 protein networkhttps://string-db.org/network/9606.ENSP00000310216NKG2-F type II integral membrane protein; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells.
HSPA6 protein networkhttps://string-db.org/network/9606.ENSP00000310219Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized p [...]
RAB1B protein networkhttps://string-db.org/network/9606.ENSP00000310226Ras-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
SLC22A13 protein networkhttps://string-db.org/network/9606.ENSP00000310241Solute carrier family 22 member 13.
RASGRP1 protein networkhttps://string-db.org/network/9606.ENSP00000310244RAS guanyl-releasing protein 1; Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activa [...]
GPR152 protein networkhttps://string-db.org/network/9606.ENSP00000310255Probable G-protein coupled receptor 152; Orphan receptor.
INTS6 protein networkhttps://string-db.org/network/9606.ENSP00000310260Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
TNFRSF10D protein networkhttps://string-db.org/network/9606.ENSP00000310263Tumor necrosis factor receptor superfamily member 10D; Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects again [...]
SP3 protein networkhttps://string-db.org/network/9606.ENSP00000310301Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements [...]
TOPAZ1 protein networkhttps://string-db.org/network/9606.ENSP00000310303Protein TOPAZ1; Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for no [...]
P2RY2 protein networkhttps://string-db.org/network/9606.ENSP00000310305P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylt [...]
FBXO45 protein networkhttps://string-db.org/network/9606.ENSP00000310332F-box/SPRY domain-containing protein 1; Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Play [...]
REP15 protein networkhttps://string-db.org/network/9606.ENSP00000310335Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment.
RESF1 protein networkhttps://string-db.org/network/9606.ENSP00000310338Retroelement silencing factor 1; Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or [...]
RMI2 protein networkhttps://string-db.org/network/9606.ENSP00000310356RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is requi [...]
MLC1 protein networkhttps://string-db.org/network/9606.ENSP00000310375Membrane protein MLC1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx.
XCR1 protein networkhttps://string-db.org/network/9606.ENSP00000310405Chemokine XC receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin.
RIN1 protein networkhttps://string-db.org/network/9606.ENSP00000310406Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First [...]
LMAN1L protein networkhttps://string-db.org/network/9606.ENSP00000310431Protein ERGIC-53-like; Lectin, mannose binding 1 like.
GLS2 protein networkhttps://string-db.org/network/9606.ENSP00000310447Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing [...]
SART1 protein networkhttps://string-db.org/network/9606.ENSP00000310448U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to th [...]
AKIP1 protein networkhttps://string-db.org/network/9606.ENSP00000310459A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRK [...]
ZNF624 protein networkhttps://string-db.org/network/9606.ENSP00000310472Zinc finger protein 624; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SLC16A11 protein networkhttps://string-db.org/network/9606.ENSP00000310490Monocarboxylate transporter 11; Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overex [...]
ARHGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000310491Rho GTPase-activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.
PRM1 protein networkhttps://string-db.org/network/9606.ENSP00000310515Sperm protamine P1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive c [...]
ERCC4 protein networkhttps://string-db.org/network/9606.ENSP00000310520DNA repair endonuclease XPF; Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that [...]
SEC22A protein networkhttps://string-db.org/network/9606.ENSP00000310521Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex.
ADCK5 protein networkhttps://string-db.org/network/9606.ENSP00000310547Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosp [...]
LCLAT1 protein networkhttps://string-db.org/network/9606.ENSP00000310551Lysocardiolipin acyltransferase 1; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeli [...]
KCNE3 protein networkhttps://string-db.org/network/9606.ENSP00000310557Potassium voltage-gated channel subfamily E member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...]
ARHGAP32 protein networkhttps://string-db.org/network/9606.ENSP00000310561Rho GTPase-activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during t [...]
DSEL protein networkhttps://string-db.org/network/9606.ENSP00000310565Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family.
PSMC5 protein networkhttps://string-db.org/network/9606.ENSP0000031057226S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
KRT25 protein networkhttps://string-db.org/network/9606.ENSP00000310573Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) ( [...]
PCP2 protein networkhttps://string-db.org/network/9606.ENSP00000310585Purkinje cell protein 2 homolog; May function as a cell-type specific modulator for G protein- mediated cell signaling.
MAP9 protein networkhttps://string-db.org/network/9606.ENSP00000310593Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing inter [...]
FNDC9 protein networkhttps://string-db.org/network/9606.ENSP00000310594Fibronectin type III domain containing 9.
LSM1 protein networkhttps://string-db.org/network/9606.ENSP00000310596U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing [...]
SNX32 protein networkhttps://string-db.org/network/9606.ENSP00000310620Sorting nexin-32; May be involved in several stages of intracellular trafficking.
APOBEC4 protein networkhttps://string-db.org/network/9606.ENSP00000310622Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known.
ISCU protein networkhttps://string-db.org/network/9606.ENSP00000310623Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mi [...]
MRGPRD protein networkhttps://string-db.org/network/9606.ENSP00000310631Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for [...]
OR8S1 protein networkhttps://string-db.org/network/9606.ENSP00000310632Olfactory receptor 8S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
BRSK1 protein networkhttps://string-db.org/network/9606.ENSP00000310649Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, [...]
NDST2 protein networkhttps://string-db.org/network/9606.ENSP00000310657Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...]
SCUBE2 protein networkhttps://string-db.org/network/9606.ENSP00000310658Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhN [...]
PDE7B protein networkhttps://string-db.org/network/9606.ENSP00000310661cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-m [...]
NUP93 protein networkhttps://string-db.org/network/9606.ENSP00000310668Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal developme [...]
CCAR2 protein networkhttps://string-db.org/network/9606.ENSP00000310670Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and [...]
ABCD2 protein networkhttps://string-db.org/network/9606.ENSP00000310688ATP-binding cassette sub-family D member 2; Probable transporter; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
B4GALT2 protein networkhttps://string-db.org/network/9606.ENSP00000310696Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce la [...]
CYP7B1 protein networkhttps://string-db.org/network/9606.ENSP00000310721Cytochrome P450 7B1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inse [...]
MOS protein networkhttps://string-db.org/network/9606.ENSP00000310722MOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
DDX23 protein networkhttps://string-db.org/network/9606.ENSP00000310723Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation.
MRPL57 protein networkhttps://string-db.org/network/9606.ENSP00000310726Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family.
OR1L1 protein networkhttps://string-db.org/network/9606.ENSP00000310773Olfactory receptor 1L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5J2 protein networkhttps://string-db.org/network/9606.ENSP00000310788Olfactory receptor 5J2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
THAP2 protein networkhttps://string-db.org/network/9606.ENSP00000310796THAP domain containing 2.
LKAAEAR1 protein networkhttps://string-db.org/network/9606.ENSP00000310801Protein LKAAEAR1; LKAAEAR motif containing 1.
SFT2D3 protein networkhttps://string-db.org/network/9606.ENSP00000310803Vesicle transport protein SFT2C; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.
CFAP70 protein networkhttps://string-db.org/network/9606.ENSP00000310829Cilia and flagella associated protein 70; Belongs to the CFAP70 family.
CTSF protein networkhttps://string-db.org/network/9606.ENSP00000310832Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
FBXO31 protein networkhttps://string-db.org/network/9606.ENSP00000310841F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin- [...]
FANCI protein networkhttps://string-db.org/network/9606.ENSP00000310842Fanconi anemia group I protein; Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting [...]
VN1R4 protein networkhttps://string-db.org/network/9606.ENSP00000310856Vomeronasal type-1 receptor 4; Putative pheromone receptor; Belongs to the G-protein coupled receptor 1 family.
KRT2 protein networkhttps://string-db.org/network/9606.ENSP00000310861Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. Plays a role in the establish [...]
COQ2 protein networkhttps://string-db.org/network/9606.ENSP000003108734-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction [...]
MAL protein networkhttps://string-db.org/network/9606.ENSP00000310880Myelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis an [...]
CSRP2 protein networkhttps://string-db.org/network/9606.ENSP00000310901Cysteine and glycine-rich protein 2; Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in [...]
PPARD protein networkhttps://string-db.org/network/9606.ENSP00000310928Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference [...]
MADD protein networkhttps://string-db.org/network/9606.ENSP00000310933MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell prolife [...]
PHYKPL protein networkhttps://string-db.org/network/9606.ENSP000003109785-phosphohydroxy-L-lysine phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5- phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semi [...]
NAGPA protein networkhttps://string-db.org/network/9606.ENSP00000310998N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by [...]
MAPK7 protein networkhttps://string-db.org/network/9606.ENSP00000311005Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. [...]
ELF5 protein networkhttps://string-db.org/network/9606.ENSP00000311010ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. Belongs to the ETS family.
ABCC12 protein networkhttps://string-db.org/network/9606.ENSP00000311030Multidrug resistance-associated protein 9; Probable transporter.
CASP3 protein networkhttps://string-db.org/network/9606.ENSP00000311032Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) [...]
CD200R1 protein networkhttps://string-db.org/network/9606.ENSP00000311035Cell surface glycoprotein CD200 receptor 1; Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules includin [...]
OR6M1 protein networkhttps://string-db.org/network/9606.ENSP00000311038Olfactory receptor 6M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CKS1B protein networkhttps://string-db.org/network/9606.ENSP00000311083Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
CYP4A11 protein networkhttps://string-db.org/network/9606.ENSP00000311095Cytochrome P450 4A11; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one [...]
PSMA8 protein networkhttps://string-db.org/network/9606.ENSP00000311121Proteasome subunit alpha-type 8; Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating [...]
TMEM52 protein networkhttps://string-db.org/network/9606.ENSP00000311122Transmembrane protein 52.
VEGFB protein networkhttps://string-db.org/network/9606.ENSP00000311127Vascular endothelial growth factor B; Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
DHX37 protein networkhttps://string-db.org/network/9606.ENSP00000311135Probable ATP-dependent RNA helicase DHX37; DEAH-box helicase 37.
AQP1 protein networkhttps://string-db.org/network/9606.ENSP00000311165Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the di [...]
ZNF497 protein networkhttps://string-db.org/network/9606.ENSP00000311183Zinc finger protein 497; May be involved in transcriptional regulation.
WFIKKN2 protein networkhttps://string-db.org/network/9606.ENSP00000311184WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metallopro [...]
NPAS4 protein networkhttps://string-db.org/network/9606.ENSP00000311196Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contex [...]
C1orf100 protein networkhttps://string-db.org/network/9606.ENSP00000311218Uncharacterized protein C1orf100; Chromosome 1 open reading frame 100.
TRIM59 protein networkhttps://string-db.org/network/9606.ENSP00000311219Tripartite motif-containing protein 59; May serve as a multifunctional regulator for innate immune signaling pathways.
ZMAT3 protein networkhttps://string-db.org/network/9606.ENSP00000311221Zinc finger matrin-type protein 3; Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regul [...]
ACOT1 protein networkhttps://string-db.org/network/9606.ENSP00000311224Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular leve [...]
STOX2 protein networkhttps://string-db.org/network/9606.ENSP00000311257Storkhead-box protein 2; Storkhead box 2.
DNAH7 protein networkhttps://string-db.org/network/9606.ENSP00000311273Dynein heavy chain 7, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
ELF4 protein networkhttps://string-db.org/network/9606.ENSP00000311280ETS-related transcription factor Elf-4; Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor gene [...]
PROP1 protein networkhttps://string-db.org/network/9606.ENSP00000311290Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
SLCO2A1 protein networkhttps://string-db.org/network/9606.ENSP00000311291Solute carrier organic anion transporter family member 2A1; May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the cleara [...]
CTSW protein networkhttps://string-db.org/network/9606.ENSP00000311300Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family.
CST6 protein networkhttps://string-db.org/network/9606.ENSP00000311313Cystatin-M; Shows moderate inhibition of cathepsin B but is not active against cathepsin C; Belongs to the cystatin family.
ATG4D protein networkhttps://string-db.org/network/9606.ENSP00000311318Cysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG [...]
ZNF417 protein networkhttps://string-db.org/network/9606.ENSP00000311319Zinc finger protein 417; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP8B3 protein networkhttps://string-db.org/network/9606.ENSP00000311336Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membran [...]
WDR49 protein networkhttps://string-db.org/network/9606.ENSP00000311343WD repeat domain 49.
PPP2R1B protein networkhttps://string-db.org/network/9606.ENSP00000311344Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the cat [...]
RAD9A protein networkhttps://string-db.org/network/9606.ENSP00000311360Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon [...]
MUCL1 protein networkhttps://string-db.org/network/9606.ENSP00000311364Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer.
POLD4 protein networkhttps://string-db.org/network/9606.ENSP00000311368DNA polymerase delta subunit 4; As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, incre [...]
RNASE8 protein networkhttps://string-db.org/network/9606.ENSP00000311398Ribonuclease 8; Has a low ribonuclease activity.
VPS26C protein networkhttps://string-db.org/network/9606.ENSP00000311399Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) an [...]
DENND6A protein networkhttps://string-db.org/network/9606.ENSP00000311401Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 [...]
ADCY6 protein networkhttps://string-db.org/network/9606.ENSP00000311405Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta- adrenergic receptor [...]
SNX33 protein networkhttps://string-db.org/network/9606.ENSP00000311427Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during i [...]
ZWILCH protein networkhttps://string-db.org/network/9606.ENSP00000311429Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 comple [...]
RPL4 protein networkhttps://string-db.org/network/9606.ENSP00000311430Ribosomal protein L4.
ABRA protein networkhttps://string-db.org/network/9606.ENSP00000311436Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)-dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanis [...]
ASPHD1 protein networkhttps://string-db.org/network/9606.ENSP00000311447Aspartate beta-hydroxylase domain containing 1.
RAB6A protein networkhttps://string-db.org/network/9606.ENSP00000311449Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independe [...]
GSTM1 protein networkhttps://string-db.org/network/9606.ENSP00000311469Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
OR10AG1 protein networkhttps://string-db.org/network/9606.ENSP00000311477Olfactory receptor 10AG1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
C11orf86 protein networkhttps://string-db.org/network/9606.ENSP00000311479Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86.
C12orf66 protein networkhttps://string-db.org/network/9606.ENSP00000311486KICSTOR complex protein C12orf66; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GAT [...]
ISX protein networkhttps://string-db.org/network/9606.ENSP00000311492Intestine-specific homeobox; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine ( [...]
MZT2A protein networkhttps://string-db.org/network/9606.ENSP00000311500Mitotic spindle organizing protein 2A; Belongs to the MOZART2 family.
HEG1 protein networkhttps://string-db.org/network/9606.ENSP00000311502Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial ce [...]
IQCB1 protein networkhttps://string-db.org/network/9606.ENSP00000311505IQ calmodulin-binding motif-containing protein 1; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation o [...]
RSF1 protein networkhttps://string-db.org/network/9606.ENSP00000311513Remodeling and spacing factor 1; Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX t [...]
ZNF490 protein networkhttps://string-db.org/network/9606.ENSP00000311521Zinc finger protein 490; May be involved in transcriptional regulation.
GPR162 protein networkhttps://string-db.org/network/9606.ENSP00000311528Probable G-protein coupled receptor 162; Orphan receptor.
ARR3 protein networkhttps://string-db.org/network/9606.ENSP00000311538Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.
ADGRE1 protein networkhttps://string-db.org/network/9606.ENSP00000311545Adhesion G protein-coupled receptor E1; Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regu [...]
TNKS protein networkhttps://string-db.org/network/9606.ENSP00000311579Poly [ADP-ribose] polymerase tankyrase-1; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of [...]
OR4B1 protein networkhttps://string-db.org/network/9606.ENSP00000311605Olfactory receptor 4B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SPSB4 protein networkhttps://string-db.org/network/9606.ENSP00000311609SPRY domain-containing SOCS box protein 4; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitina [...]
UGT8 protein networkhttps://string-db.org/network/9606.ENSP000003116482-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingo [...]
GRAMD2A protein networkhttps://string-db.org/network/9606.ENSP00000311657GRAM domain-containing protein 2A; Participates in the organization of endoplasmic reticulum- plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calci [...]
PPP1R8 protein networkhttps://string-db.org/network/9606.ENSP00000311677Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-ass [...]
ZNF483 protein networkhttps://string-db.org/network/9606.ENSP00000311679Zinc finger protein 483; May be involved in transcriptional regulation.
SPEG protein networkhttps://string-db.org/network/9606.ENSP00000311684Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; Belongs to the protein kinase supe [...]
NIPAL4 protein networkhttps://string-db.org/network/9606.ENSP00000311687Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity [...]
CCDC85B protein networkhttps://string-db.org/network/9606.ENSP00000311695Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth. May function in a [...]
FGF5 protein networkhttps://string-db.org/network/9606.ENSP00000311697Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhi [...]
RTP1 protein networkhttps://string-db.org/network/9606.ENSP00000311712Receptor-transporting protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs; Belongs to the TMEM7 family.
OXSR1 protein networkhttps://string-db.org/network/9606.ENSP00000311713Serine/threonine-protein kinase OSR1; Phosphorylates RELL1, RELL2 and RELT. Phosphorylates PAK1. Phosphorylates PLSCR1 in the presence of RELT. Belongs to the protein kinase superfamily. STE Ser/ [...]
KLK10 protein networkhttps://string-db.org/network/9606.ENSP00000311746Kallikrein-10; Has a tumor-suppressor role for NES1 in breast and prostate cancer; Belongs to the peptidase S1 family. Kallikrein subfamily.
RBM14 protein networkhttps://string-db.org/network/9606.ENSP00000311747RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcript [...]
TTC9B protein networkhttps://string-db.org/network/9606.ENSP00000311760Tetratricopeptide repeat domain 9B; Belongs to the TTC9 family.
ZMIZ2 protein networkhttps://string-db.org/network/9606.ENSP00000311778Zinc finger MIZ domain-containing protein 2; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.
REST protein networkhttps://string-db.org/network/9606.ENSP00000311816RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the [...]
CTBP2 protein networkhttps://string-db.org/network/9606.ENSP00000311825C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-h [...]
MSL2 protein networkhttps://string-db.org/network/9606.ENSP00000311827E3 ubiquitin-protein ligase MSL2; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher [...]
SLC37A2 protein networkhttps://string-db.org/network/9606.ENSP00000311833Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and transl [...]
SNTG2 protein networkhttps://string-db.org/network/9606.ENSP00000311837Gamma-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystro [...]
PTPN2 protein networkhttps://string-db.org/network/9606.ENSP00000311857Tyrosine-protein phosphatase non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also [...]
MS4A10 protein networkhttps://string-db.org/network/9606.ENSP00000311862Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
DAW1 protein networkhttps://string-db.org/network/9606.ENSP00000311899Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly. Belongs to the WD repeat WDR69 family.
LTBP4 protein networkhttps://string-db.org/network/9606.ENSP00000311905Latent-transforming growth factor beta-binding protein 4; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent [...]
ZNF738 protein networkhttps://string-db.org/network/9606.ENSP00000311957Protein ZNF738; May be involved in transcriptional regulation.
GGA2 protein networkhttps://string-db.org/network/9606.ENSP00000311962ADP-ribosylation factor-binding protein GGA2; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathr [...]
DUS3L protein networkhttps://string-db.org/network/9606.ENSP00000311977tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus3 subfamily.
NAXD protein networkhttps://string-db.org/network/9606.ENSP00000311984ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which cataly [...]
NEFH protein networkhttps://string-db.org/network/9606.ENSP00000311997Neurofilament heavy polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important [...]
HAVCR2 protein networkhttps://string-db.org/network/9606.ENSP00000312002Hepatitis A virus cellular receptor 2; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulati [...]
TLCD3A protein networkhttps://string-db.org/network/9606.ENSP00000312017TLC domain containing 3A.
FUT1 protein networkhttps://string-db.org/network/9606.ENSP00000312021Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the s [...]
CD7 protein networkhttps://string-db.org/network/9606.ENSP00000312027T-cell antigen CD7; Not yet known.
SRP68 protein networkhttps://string-db.org/network/9606.ENSP00000312066Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S [...]
PCDHGC3 protein networkhttps://string-db.org/network/9606.ENSP00000312070Protocadherin gamma-C3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
SSH3 protein networkhttps://string-db.org/network/9606.ENSP00000312081Protein phosphatase Slingshot homolog 3; Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing [...]
TLR8 protein networkhttps://string-db.org/network/9606.ENSP00000312082Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific [...]
UBXN2A protein networkhttps://string-db.org/network/9606.ENSP00000312107UBX domain protein 2A.
ADCY4 protein networkhttps://string-db.org/network/9606.ENSP00000312126Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
KCNG4 protein networkhttps://string-db.org/network/9606.ENSP00000312129Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...]
PRG2 protein networkhttps://string-db.org/network/9606.ENSP00000312134Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hy [...]
TNS3 protein networkhttps://string-db.org/network/9606.ENSP00000312143Tensin-3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of I [...]
TRIB1 protein networkhttps://string-db.org/network/9606.ENSP00000312150Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1- binding motif is masked by autoinhibitory interactions with the protein ki [...]
BTN2A1 protein networkhttps://string-db.org/network/9606.ENSP00000312158Butyrophilin subfamily 2 member A1.
ELMO1 protein networkhttps://string-db.org/network/9606.ENSP00000312185Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...]
ZHX3 protein networkhttps://string-db.org/network/9606.ENSP00000312222Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene [...]
DTD2 protein networkhttps://string-db.org/network/9606.ENSP00000312224D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs (By similarity). Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS (By simil [...]
MSL3 protein networkhttps://string-db.org/network/9606.ENSP00000312244Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority [...]
ADPGK protein networkhttps://string-db.org/network/9606.ENSP00000312250ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By simi [...]
GRK2 protein networkhttps://string-db.org/network/9606.ENSP00000312262Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key reg [...]
YPEL2 protein networkhttps://string-db.org/network/9606.ENSP00000312272Protein yippee-like 2; Yippee like 2.
LGI4 protein networkhttps://string-db.org/network/9606.ENSP00000312273Leucine-rich repeat LGI family member 4; Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).
SPESP1 protein networkhttps://string-db.org/network/9606.ENSP00000312284Sperm equatorial segment protein 1; Involved in fertilization ability of sperm. Belongs to the SPESP1 family.
PLA2G1B protein networkhttps://string-db.org/network/9606.ENSP00000312286Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precurso [...]
MOBP protein networkhttps://string-db.org/network/9606.ENSP00000312293Myelin-associated oligodendrocyte basic protein; May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic [...]
FRG2C protein networkhttps://string-db.org/network/9606.ENSP00000312299Protein FRG2-like-2; FSHD region gene 2 family member C.
TPMT protein networkhttps://string-db.org/network/9606.ENSP00000312304Thiopurine S-methyltransferase; Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also c [...]
MRPL46 protein networkhttps://string-db.org/network/9606.ENSP00000312311Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family.
ZNRD2 protein networkhttps://string-db.org/network/9606.ENSP00000312318Protein ZNRD2; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies.
AOC3 protein networkhttps://string-db.org/network/9606.ENSP00000312326Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular end [...]
TRMT10C protein networkhttps://string-db.org/network/9606.ENSP00000312356tRNA methyltransferase 10 homolog C; Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/ [...]
CD84 protein networkhttps://string-db.org/network/9606.ENSP00000312367SLAM family member 5; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...]
SNX31 protein networkhttps://string-db.org/network/9606.ENSP00000312368Sorting nexin-31; May be involved in protein trafficking. Belongs to the sorting nexin family.
KMT2E protein networkhttps://string-db.org/network/9606.ENSP00000312379Inactive histone-lysine N-methyltransferase 2E; Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin intera [...]
EVX2 protein networkhttps://string-db.org/network/9606.ENSP00000312385Even-skipped homeobox 2; Belongs to the even-skipped homeobox family.
KLHL3 protein networkhttps://string-db.org/network/9606.ENSP00000312397Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts [...]
CCDC63 protein networkhttps://string-db.org/network/9606.ENSP00000312399Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads.
OR2Y1 protein networkhttps://string-db.org/network/9606.ENSP00000312403Olfactory receptor 2Y1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PPM1E protein networkhttps://string-db.org/network/9606.ENSP00000312411Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhi [...]
SSX5 protein networkhttps://string-db.org/network/9606.ENSP00000312415Protein SSX5; Could act as a modulator of transcription.
RNF26 protein networkhttps://string-db.org/network/9606.ENSP00000312439E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear po [...]
AP1G2 protein networkhttps://string-db.org/network/9606.ENSP00000312442AP-1 complex subunit gamma-like 2; May function in protein sorting in late endosomes or multivesucular bodies (MVBs).
CFLAR protein networkhttps://string-db.org/network/9606.ENSP00000312455CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an [...]
BAALC protein networkhttps://string-db.org/network/9606.ENSP00000312457BAALC binder of MAP3K1 and KLF4.
ARV1 protein networkhttps://string-db.org/network/9606.ENSP00000312458Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membr [...]
CSPG4 protein networkhttps://string-db.org/network/9606.ENSP00000312506Chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibi [...]
LRFN4 protein networkhttps://string-db.org/network/9606.ENSP00000312535Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By simil [...]
DNAH12 protein networkhttps://string-db.org/network/9606.ENSP00000312554Dynein heavy chain 12, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
COQ10A protein networkhttps://string-db.org/network/9606.ENSP00000312587Coenzyme Q-binding protein COQ10 homolog A, mitochondrial; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 fro [...]
TMEM70 protein networkhttps://string-db.org/network/9606.ENSP00000312599Transmembrane protein 70, mitochondrial; Involved in biogenesis of mitochondrial ATP synthase. Belongs to the TMEM70 family.
TMEM134 protein networkhttps://string-db.org/network/9606.ENSP00000312615Transmembrane protein 134.
NFYC protein networkhttps://string-db.org/network/9606.ENSP00000312617Nuclear transcription factor Y subunit gamma; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the prom [...]
ACAD9 protein networkhttps://string-db.org/network/9606.ENSP00000312618Complex I assembly factor ACAD9, mitochondrial; As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphor [...]
TCAP protein networkhttps://string-db.org/network/9606.ENSP00000312624Telethonin; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
INSM1 protein networkhttps://string-db.org/network/9606.ENSP00000312631Insulinoma-associated protein 1; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or feta [...]
PDLIM2 protein networkhttps://string-db.org/network/9606.ENSP00000312634PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression en [...]
PPARGC1B protein networkhttps://string-db.org/network/9606.ENSP00000312649Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of es [...]
LEP protein networkhttps://string-db.org/network/9606.ENSP00000312652Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, whic [...]
CHRNA9 protein networkhttps://string-db.org/network/9606.ENSP00000312663Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the op [...]
CASP2 protein networkhttps://string-db.org/network/9606.ENSP00000312664Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivatin [...]
EHBP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000312671EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking.
TLCD5 protein networkhttps://string-db.org/network/9606.ENSP00000312672TLC domain containing 5; Belongs to the TLCD5 family.
GH1 protein networkhttps://string-db.org/network/9606.ENSP00000312673Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentia [...]
TRIM72 protein networkhttps://string-db.org/network/9606.ENSP00000312675Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically [...]
B3GNT8 protein networkhttps://string-db.org/network/9606.ENSP00000312700UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N- glyc [...]
DEFB114 protein networkhttps://string-db.org/network/9606.ENSP00000312702Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram- negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and [...]
CCDC65 protein networkhttps://string-db.org/network/9606.ENSP00000312706Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dis [...]
TAF7 protein networkhttps://string-db.org/network/9606.ENSP00000312709Transcription initiation factor TFIID subunit 7; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in [...]
RAB8B protein networkhttps://string-db.org/network/9606.ENSP00000312734Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
CAMKK2 protein networkhttps://string-db.org/network/9606.ENSP00000312741Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular proc [...]
PHETA2 protein networkhttps://string-db.org/network/9606.ENSP00000312753Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian fam [...]
CEP295NL protein networkhttps://string-db.org/network/9606.ENSP00000312767CEP295 N-terminal-like protein; CEP295 N-terminal like.
C2orf69 protein networkhttps://string-db.org/network/9606.ENSP00000312770UPF0565 protein C2orf69; Chromosome 2 open reading frame 69.
SPACA4 protein networkhttps://string-db.org/network/9606.ENSP00000312774Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization.
IFT80 protein networkhttps://string-db.org/network/9606.ENSP00000312778Intraflagellar transport protein 80 homolog; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.
KCNK10 protein networkhttps://string-db.org/network/9606.ENSP00000312811Potassium channel subfamily K member 10; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and [...]
KCTD2 protein networkhttps://string-db.org/network/9606.ENSP00000312814BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2.
MLXIP protein networkhttps://string-db.org/network/9606.ENSP00000312834MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycoly [...]
SEZ6 protein networkhttps://string-db.org/network/9606.ENSP00000312942Seizure protein 6 homolog; May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongat [...]
STAB1 protein networkhttps://string-db.org/network/9606.ENSP00000312946Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. [...]
USP39 protein networkhttps://string-db.org/network/9606.ENSP00000312981U4/U6.U5 tri-snRNP-associated protein 2; Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mR [...]
HNF4A protein networkhttps://string-db.org/network/9606.ENSP00000312987Hepatocyte nuclear factor 4-alpha; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the [...]
NFKBIB protein networkhttps://string-db.org/network/9606.ENSP00000312988NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kapp [...]
CLSPN protein networkhttps://string-db.org/network/9606.ENSP00000312995Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds [...]
GNAI2 protein networkhttps://string-db.org/network/9606.ENSP00000312999Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The [...]
PABPC1 protein networkhttps://string-db.org/network/9606.ENSP00000313007Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its [...]
FBXW5 protein networkhttps://string-db.org/network/9606.ENSP00000313034F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition [...]
NIPSNAP2 protein networkhttps://string-db.org/network/9606.ENSP00000313050Protein NipSnap homolog 2; May act as a positive regulator of L-type calcium channels. Belongs to the NipSnap family.
SHISA2 protein networkhttps://string-db.org/network/9606.ENSP00000313079Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family.
NETO1 protein networkhttps://string-db.org/network/9606.ENSP00000313088Neuropilin and tolloid-like protein 1; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for m [...]
OR6S1 protein networkhttps://string-db.org/network/9606.ENSP00000313110Olfactory receptor 6S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SNX14 protein networkhttps://string-db.org/network/9606.ENSP00000313121Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for [...]
EXD2 protein networkhttps://string-db.org/network/9606.ENSP00000313140Exonuclease 3'-5' domain-containing protein 2; Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In pre [...]
ZNF366 protein networkhttps://string-db.org/network/9606.ENSP00000313158Zinc finger protein 366; Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.
FBXO34 protein networkhttps://string-db.org/network/9606.ENSP00000313159F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
NPHP1 protein networkhttps://string-db.org/network/9606.ENSP00000313169Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with N [...]
ATAD5 protein networkhttps://string-db.org/network/9606.ENSP00000313171ATPase family AAA domain-containing protein 5; Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is com [...]
BVES protein networkhttps://string-db.org/network/9606.ENSP00000313172Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) p [...]
HNRNPD protein networkhttps://string-db.org/network/9606.ENSP00000313199Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU- rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Als [...]
CTXN1 protein networkhttps://string-db.org/network/9606.ENSP00000313226Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family.
HSF5 protein networkhttps://string-db.org/network/9606.ENSP00000313243Heat shock factor protein 5; May act as a transcriptional factor.
FUZ protein networkhttps://string-db.org/network/9606.ENSP00000313309Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of t [...]
SLC35C1 protein networkhttps://string-db.org/network/9606.ENSP00000313318GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily.
C3orf80 protein networkhttps://string-db.org/network/9606.ENSP00000313324Uncharacterized membrane protein C3orf80; Chromosome 3 open reading frame 80.
RNASEH1 protein networkhttps://string-db.org/network/9606.ENSP00000313350Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid forma [...]
PANK2 protein networkhttps://string-db.org/network/9606.ENSP00000313377Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis. Belongs to the type II pantothenate kinase family.
OR1E1 protein networkhttps://string-db.org/network/9606.ENSP00000313384Olfactory receptor 1E1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DAB2 protein networkhttps://string-db.org/network/9606.ENSP00000313391Disabled homolog 2; Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clat [...]
CD19 protein networkhttps://string-db.org/network/9606.ENSP00000313419B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for [...]
PRKDC protein networkhttps://string-db.org/network/9606.ENSP00000313420DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for doub [...]
ARL6IP4 protein networkhttps://string-db.org/network/9606.ENSP00000313422ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. I [...]
GFRA4 protein networkhttps://string-db.org/network/9606.ENSP00000313423GDNF family receptor alpha-4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnata [...]
GRHPR protein networkhttps://string-db.org/network/9606.ENSP00000313432Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glyce [...]
MMP19 protein networkhttps://string-db.org/network/9606.ENSP00000313437Matrix metalloproteinase-19; Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemo [...]
ZNF491 protein networkhttps://string-db.org/network/9606.ENSP00000313443Zinc finger protein 491; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
UBA6 protein networkhttps://string-db.org/network/9606.ENSP00000313454Ubiquitin-like modifier-activating enzyme 6; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine [...]
PFAS protein networkhttps://string-db.org/network/9606.ENSP00000313490Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ri [...]
HROB protein networkhttps://string-db.org/network/9606.ENSP00000313500Uncharacterized protein C17orf53; Homologous recombination factor with OB-fold.
PHKB protein networkhttps://string-db.org/network/9606.ENSP00000313504Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory uni [...]
LGALS7B protein networkhttps://string-db.org/network/9606.ENSP00000313571Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and [...]
KLK2 protein networkhttps://string-db.org/network/9606.ENSP00000313581Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily.
ZNF436 protein networkhttps://string-db.org/network/9606.ENSP00000313582Zinc finger protein 436; May be a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP10B protein networkhttps://string-db.org/network/9606.ENSP00000313600Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...]
CC2D1A protein networkhttps://string-db.org/network/9606.ENSP00000313601Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The com [...]
ABCF1 protein networkhttps://string-db.org/network/9606.ENSP00000313603ATP-binding cassette sub-family F member 1; Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.
ALS2CL protein networkhttps://string-db.org/network/9606.ENSP00000313670ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.
SPHK1 protein networkhttps://string-db.org/network/9606.ENSP00000313681Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sph [...]
FTMT protein networkhttps://string-db.org/network/9606.ENSP00000313691Ferritin, mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited [...]
HEPHL1 protein networkhttps://string-db.org/network/9606.ENSP00000313699Ferroxidase HEPHL1; Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intrace [...]
SSNA1 protein networkhttps://string-db.org/network/9606.ENSP00000313752SS nuclear autoantigen 1.
OR3A1 protein networkhttps://string-db.org/network/9606.ENSP00000313803Olfactory receptor 3A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
AMBN protein networkhttps://string-db.org/network/9606.ENSP00000313809Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family.
USP20 protein networkhttps://string-db.org/network/9606.ENSP00000313811Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by m [...]
KHDRBS1 protein networkhttps://string-db.org/network/9606.ENSP00000313829KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptor [...]
LCN15 protein networkhttps://string-db.org/network/9606.ENSP00000313833Lipocalin-15; Lipocalin 15.
PDS5B protein networkhttps://string-db.org/network/9606.ENSP00000313851Sister chromatid cohesion protein PDS5 homolog B; Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid coh [...]
CLPTM1L protein networkhttps://string-db.org/network/9606.ENSP00000313854Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed. Belongs to the CLPTM1 family.
GORASP1 protein networkhttps://string-db.org/network/9606.ENSP00000313869Golgi reassembly-stacking protein 1; Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis. Key st [...]
CD46 protein networkhttps://string-db.org/network/9606.ENSP00000313875Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on ho [...]
TSFM protein networkhttps://string-db.org/network/9606.ENSP00000313877Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolys [...]
MKRN3 protein networkhttps://string-db.org/network/9606.ENSP00000313881Probable E3 ubiquitin-protein ligase makorin-3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
MSRA protein networkhttps://string-db.org/network/9606.ENSP00000313921Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reducti [...]
BICRAL protein networkhttps://string-db.org/network/9606.ENSP00000313933BRD4-interacting chromatin-remodeling complex-associated protein-like; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin stru [...]
OR2AE1 protein networkhttps://string-db.org/network/9606.ENSP00000313936Olfactory receptor 2AE1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
AURKB protein networkhttps://string-db.org/network/9606.ENSP00000313950Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions a [...]
TTC27 protein networkhttps://string-db.org/network/9606.ENSP00000313953Tetratricopeptide repeat domain 27.
C1QB protein networkhttps://string-db.org/network/9606.ENSP00000313967Complement C1q subcomponent subunit B; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...]
NSD3 protein networkhttps://string-db.org/network/9606.ENSP00000313983Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents [...]
KLHDC3 protein networkhttps://string-db.org/network/9606.ENSP00000313995Kelch domain-containing protein 3; May be involved in meiotic recombination process.
ANAPC2 protein networkhttps://string-db.org/network/9606.ENSP00000314004Anaphase-promoting complex subunit 2; Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 [...]
SIDT2 protein networkhttps://string-db.org/network/9606.ENSP00000314023SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported [...]
SENP3 protein networkhttps://string-db.org/network/9606.ENSP00000314029Sentrin-specific protease 3; Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which [...]
DNAJA2 protein networkhttps://string-db.org/network/9606.ENSP00000314030DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
AGPAT4 protein networkhttps://string-db.org/network/9606.ENSP000003140361-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by i [...]
MRGPRX4 protein networkhttps://string-db.org/network/9606.ENSP00000314042Mas-related G-protein coupled receptor member X4; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...]
PAK2 protein networkhttps://string-db.org/network/9606.ENSP00000314067Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle [...]
HIC1 protein networkhttps://string-db.org/network/9606.ENSP00000314080Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in devel [...]
CA5B protein networkhttps://string-db.org/network/9606.ENSP00000314099Carbonic anhydrase 5B, mitochondrial; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family.
TMEM107 protein networkhttps://string-db.org/network/9606.ENSP00000314116Transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GL [...]
TFE3 protein networkhttps://string-db.org/network/9606.ENSP00000314129Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or wit [...]
BOK protein networkhttps://string-db.org/network/9606.ENSP00000314132Bcl-2-related ovarian killer protein; [Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regula [...]
KLK3 protein networkhttps://string-db.org/network/9606.ENSP00000314151Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
SNAP47 protein networkhttps://string-db.org/network/9606.ENSP00000314157Synaptosomal-associated protein 47; Plays a role in intracellular membrane fusion.
SAMD12 protein networkhttps://string-db.org/network/9606.ENSP00000314173Sterile alpha motif domain containing 12.
WDR75 protein networkhttps://string-db.org/network/9606.ENSP00000314193WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
MBOAT4 protein networkhttps://string-db.org/network/9606.ENSP00000314196Ghrelin O-acyltransferase; Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid; Belongs [...]
GPR88 protein networkhttps://string-db.org/network/9606.ENSP00000314223Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional [...]
EEF1AKMT4 protein networkhttps://string-db.org/network/9606.ENSP00000314295EEF1A lysine methyltransferase 4; Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 [...]
CFHR1 protein networkhttps://string-db.org/network/9606.ENSP00000314299Complement factor H-related protein 1; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...]
OR10Q1 protein networkhttps://string-db.org/network/9606.ENSP00000314324Olfactory receptor 10Q1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DDX10 protein networkhttps://string-db.org/network/9606.ENSP00000314348Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
GRINA protein networkhttps://string-db.org/network/9606.ENSP00000314380Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily.
PRMT9 protein networkhttps://string-db.org/network/9606.ENSP00000314396Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically m [...]
CA8 protein networkhttps://string-db.org/network/9606.ENSP00000314407Carbonic anhydrase-related protein; Does not have a carbonic anhydrase catalytic activity.
PER1 protein networkhttps://string-db.org/network/9606.ENSP00000314420Period circadian protein homolog 1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiolo [...]
METTL1 protein networkhttps://string-db.org/network/9606.ENSP00000314441tRNA (guanine-N(7)-)-methyltransferase; Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the [...]
WDR35 protein networkhttps://string-db.org/network/9606.ENSP00000314444WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it i [...]
UNCX protein networkhttps://string-db.org/network/9606.ENSP00000314480Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May [...]
MEIOB protein networkhttps://string-db.org/network/9606.ENSP00000314484Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and cro [...]
GAK protein networkhttps://string-db.org/network/9606.ENSP00000314499Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Exp [...]
GALNT14 protein networkhttps://string-db.org/network/9606.ENSP00000314500Polypeptide N-acetylgalactosaminyltransferase 14; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
MCM9 protein networkhttps://string-db.org/network/9606.ENSP00000314505DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (H [...]
GBA protein networkhttps://string-db.org/network/9606.ENSP00000314508Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a [...]
LYSMD3 protein networkhttps://string-db.org/network/9606.ENSP00000314518LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity.
MAGEB18 protein networkhttps://string-db.org/network/9606.ENSP00000314543Melanoma-associated antigen B18; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization o [...]
CCZ1B protein networkhttps://string-db.org/network/9606.ENSP00000314544CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated.
UACA protein networkhttps://string-db.org/network/9606.ENSP00000314556Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulat [...]
MAP6D1 protein networkhttps://string-db.org/network/9606.ENSP00000314560MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family.
SGSH protein networkhttps://string-db.org/network/9606.ENSP00000314606N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation. Belongs to the sulfatase family.
KLHL11 protein networkhttps://string-db.org/network/9606.ENSP00000314608Kelch-like protein 11; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their pr [...]
ARFGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000314615ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes [...]
ZFAND2A protein networkhttps://string-db.org/network/9606.ENSP00000314619Zinc finger AN1-type containing 2A.
ALDH5A1 protein networkhttps://string-db.org/network/9606.ENSP00000314649Succinate-semialdehyde dehydrogenase, mitochondrial; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
ZHX2 protein networkhttps://string-db.org/network/9606.ENSP00000314709Zinc fingers and homeoboxes protein 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it [...]
PPFIBP1 protein networkhttps://string-db.org/network/9606.ENSP00000314724Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. Belongs to the liprin family. Liprin-beta subfamily.
TOLLIP protein networkhttps://string-db.org/network/9606.ENSP00000314733Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits [...]
MBLAC2 protein networkhttps://string-db.org/network/9606.ENSP00000314776Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
BOLL protein networkhttps://string-db.org/network/9606.ENSP00000314792Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity); Belongs [...]
FOXR1 protein networkhttps://string-db.org/network/9606.ENSP00000314806Forkhead box R1.
IL1RAP protein networkhttps://string-db.org/network/9606.ENSP00000314807Interleukin-1 receptor accessory protein; Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to I [...]
EDDM3B protein networkhttps://string-db.org/network/9606.ENSP00000314810Epididymal secretory protein E3-beta; Possible function in sperm maturation.
ALOXE3 protein networkhttps://string-db.org/network/9606.ENSP00000314879Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compare [...]
ANGPT2 protein networkhttps://string-db.org/network/9606.ENSP00000314897Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence [...]
LRRN1 protein networkhttps://string-db.org/network/9606.ENSP00000314901Leucine rich repeat neuronal 1.
RPRM protein networkhttps://string-db.org/network/9606.ENSP00000314946Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC [...]
IL20RA protein networkhttps://string-db.org/network/9606.ENSP00000314976Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
RRH protein networkhttps://string-db.org/network/9606.ENSP00000314992Visual pigment-like receptor peropsin; May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compound [...]
SLC28A2 protein networkhttps://string-db.org/network/9606.ENSP00000315006Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selecti [...]
EDNRA protein networkhttps://string-db.org/network/9606.ENSP00000315011Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of bindin [...]
CRAT protein networkhttps://string-db.org/network/9606.ENSP00000315013Carnitine O-acetyltransferase; Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport [...]
MRPL1 protein networkhttps://string-db.org/network/9606.ENSP00000315017Mitochondrial ribosomal protein L1.
PPP1R42 protein networkhttps://string-db.org/network/9606.ENSP00000315035Protein phosphatase 1 regulatory subunit 42; Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.
MAGEF1 protein networkhttps://string-db.org/network/9606.ENSP00000315064Melanoma-associated antigen F1; Enhances ubiquitin ligase activity of RING-type zinc finger- containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ub [...]
GJD4 protein networkhttps://string-db.org/network/9606.ENSP00000315070Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
LSMEM2 protein networkhttps://string-db.org/network/9606.ENSP00000315081Leucine rich single-pass membrane protein 2.
EDDM3A protein networkhttps://string-db.org/network/9606.ENSP00000315098Epididymal secretory protein E3-alpha; Possible function in sperm maturation.
GPR137C protein networkhttps://string-db.org/network/9606.ENSP00000315106Integral membrane protein GPR137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes; Belongs to the GPR137 family.
RNF31 protein networkhttps://string-db.org/network/9606.ENSP00000315112E3 ubiquitin-protein ligase RNF31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in N [...]
COQ8B protein networkhttps://string-db.org/network/9606.ENSP00000315118Atypical kinase COQ8B, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respi [...]
CLU protein networkhttps://string-db.org/network/9606.ENSP00000315130Clusterin alpha chain; [Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits f [...]
APBA3 protein networkhttps://string-db.org/network/9606.ENSP00000315136Amyloid-beta A4 precursor protein-binding family A member 3; May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A [...]
SGPP2 protein networkhttps://string-db.org/network/9606.ENSP00000315137Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sp [...]
METAP1D protein networkhttps://string-db.org/network/9606.ENSP00000315152Methionine aminopeptidase 1D, mitochondrial; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is [...]
SHQ1 protein networkhttps://string-db.org/network/9606.ENSP00000315182Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthes [...]
ITGA3 protein networkhttps://string-db.org/network/9606.ENSP00000315190Integrin alpha-3 heavy chain; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha- 3/beta-1 provides a docking site for F [...]
CREG2 protein networkhttps://string-db.org/network/9606.ENSP00000315203Protein CREG2; Cellular repressor of E1A stimulated genes 2.
FAM71C protein networkhttps://string-db.org/network/9606.ENSP00000315247Protein FAM71C; Family with sequence similarity 71 member C.
GLTP protein networkhttps://string-db.org/network/9606.ENSP00000315263Glycolipid transfer protein; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transf [...]
DYNAP protein networkhttps://string-db.org/network/9606.ENSP00000315265Dynactin-associated protein; Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473'.
KIAA1549L protein networkhttps://string-db.org/network/9606.ENSP00000315295UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family.
CALML3 protein networkhttps://string-db.org/network/9606.ENSP00000315299Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 he [...]
D2HGDH protein networkhttps://string-db.org/network/9606.ENSP00000315351D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha- ketoglutarate.
ARL6IP6 protein networkhttps://string-db.org/network/9606.ENSP00000315357ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family.
C5orf46 protein networkhttps://string-db.org/network/9606.ENSP00000315370Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46.
ANO5 protein networkhttps://string-db.org/network/9606.ENSP00000315371Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity.
PRPF3 protein networkhttps://string-db.org/network/9606.ENSP00000315379U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precat [...]
ASPRV1 protein networkhttps://string-db.org/network/9606.ENSP00000315383Aspartic peptidase retroviral like 1.
POGLUT3 protein networkhttps://string-db.org/network/9606.ENSP00000315386Protein O-glucosyltransferase 3; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. [...]
TMEM102 protein networkhttps://string-db.org/network/9606.ENSP00000315387Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway.
MRPS31 protein networkhttps://string-db.org/network/9606.ENSP00000315397Mitochondrial ribosomal protein S31.
OSBPL3 protein networkhttps://string-db.org/network/9606.ENSP00000315410Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA an [...]
ALX1 protein networkhttps://string-db.org/network/9606.ENSP00000315417ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Mo [...]
DSCAML1 protein networkhttps://string-db.org/network/9606.ENSP00000315465Down syndrome cell adhesion molecule-like protein 1; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the sam [...]
GIMAP7 protein networkhttps://string-db.org/network/9606.ENSP00000315474GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits.
EXOSC4 protein networkhttps://string-db.org/network/9606.ENSP00000315476Exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
CD209 protein networkhttps://string-db.org/network/9606.ENSP00000315477CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis o [...]
ZNF875 protein networkhttps://string-db.org/network/9606.ENSP00000315505Zinc finger protein 875; May be involved in transcriptional regulation.
SPEM1 protein networkhttps://string-db.org/network/9606.ENSP00000315554Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis.
TEX44 protein networkhttps://string-db.org/network/9606.ENSP00000315557Testis-expressed protein 44; Testis expressed 44.
LGALS9B protein networkhttps://string-db.org/network/9606.ENSP00000315564Galectin-9B; Binds galactosides.
AVL9 protein networkhttps://string-db.org/network/9606.ENSP00000315568Late secretory pathway protein AVL9 homolog; Functions in cell migration.
DIS3L2 protein networkhttps://string-db.org/network/9606.ENSP00000315569DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation [...]
CHRNA3 protein networkhttps://string-db.org/network/9606.ENSP00000315602Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
ERICH5 protein networkhttps://string-db.org/network/9606.ENSP00000315614Glutamate-rich protein 5; Glutamate rich 5.
SWAP70 protein networkhttps://string-db.org/network/9606.ENSP00000315630Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase rece [...]
TYMS protein networkhttps://string-db.org/network/9606.ENSP00000315644Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
KCNG2 protein networkhttps://string-db.org/network/9606.ENSP00000315654Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belo [...]
DNMBP protein networkhttps://string-db.org/network/9606.ENSP00000315659Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. R [...]
ZNF18 protein networkhttps://string-db.org/network/9606.ENSP00000315664Zinc finger protein 18; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PEX7 protein networkhttps://string-db.org/network/9606.ENSP00000315680Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin [...]
PAM16 protein networkhttps://string-db.org/network/9606.ENSP00000315693Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase a [...]
CHAF1B protein networkhttps://string-db.org/network/9606.ENSP00000315700Chromatin assembly factor 1 subunit B; Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 per [...]
MOB4 protein networkhttps://string-db.org/network/9606.ENSP00000315702MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.
SSH1 protein networkhttps://string-db.org/network/9606.ENSP00000315713Protein phosphatase Slingshot homolog 1; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequ [...]
METRNL protein networkhttps://string-db.org/network/9606.ENSP00000315731Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following co [...]
CCNG2 protein networkhttps://string-db.org/network/9606.ENSP00000315743Cyclin-G2; May play a role in growth regulation and in negative regulation of cell cycle progression; Belongs to the cyclin family. Cyclin G subfamily.
STAT2 protein networkhttps://string-db.org/network/9606.ENSP00000315768Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding [...]
NDUFS8 protein networkhttps://string-db.org/network/9606.ENSP00000315774NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...]
COG4 protein networkhttps://string-db.org/network/9606.ENSP00000315775Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Belongs t [...]
CSTF3 protein networkhttps://string-db.org/network/9606.ENSP00000315791Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs.
ZNF575 protein networkhttps://string-db.org/network/9606.ENSP00000315870Zinc finger protein 575; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ANXA2R protein networkhttps://string-db.org/network/9606.ENSP00000315915Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation.
AHCYL2 protein networkhttps://string-db.org/network/9606.ENSP00000315931Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sen [...]
HOXD8 protein networkhttps://string-db.org/network/9606.ENSP00000315949Homeobox protein Hox-D8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
DPY19L2 protein networkhttps://string-db.org/network/9606.ENSP00000315988Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis for [...]
LILRB1 protein networkhttps://string-db.org/network/9606.ENSP00000315997Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18 [...]
SCAMP4 protein networkhttps://string-db.org/network/9606.ENSP00000316007Secretory carrier-associated membrane protein 4; Probably involved in membrane protein trafficking.
SPAG11A protein networkhttps://string-db.org/network/9606.ENSP00000316012Sperm-associated antigen 11A; May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.
TLN1 protein networkhttps://string-db.org/network/9606.ENSP00000316029Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact an [...]
NUP98 protein networkhttps://string-db.org/network/9606.ENSP00000316032Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. M [...]
HNRNPA0 protein networkhttps://string-db.org/network/9606.ENSP00000316042Heterogeneous nuclear ribonucleoprotein A0; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of c [...]
DVL3 protein networkhttps://string-db.org/network/9606.ENSP00000316054Segment polarity protein dishevelled homolog DVL-3; Involved in the signal transduction pathway mediated by multiple Wnt genes.
AGGF1 protein networkhttps://string-db.org/network/9606.ENSP00000316109Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting th [...]
SGF29 protein networkhttps://string-db.org/network/9606.ENSP00000316114SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and bin [...]
SYNE4 protein networkhttps://string-db.org/network/9606.ENSP00000316130Nesprin-4; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic intera [...]
DRICH1 protein networkhttps://string-db.org/network/9606.ENSP00000316137Aspartate-rich protein 1; Aspartate rich 1.
SFTPC protein networkhttps://string-db.org/network/9606.ENSP00000316152Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air sp [...]
B3GNT5 protein networkhttps://string-db.org/network/9606.ENSP00000316173Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on g [...]
UBE2N protein networkhttps://string-db.org/network/9606.ENSP00000316176Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination doe [...]
CLEC4M protein networkhttps://string-db.org/network/9606.ENSP00000316228C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently [...]
HTR1A protein networkhttps://string-db.org/network/9606.ENSP000003162445-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes [...]
SCD5 protein networkhttps://string-db.org/network/9606.ENSP00000316329Stearoyl-CoA desaturase 5; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyze [...]
FARS2 protein networkhttps://string-db.org/network/9606.ENSP00000316335Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m- [...]
BAIAP2 protein networkhttps://string-db.org/network/9606.ENSP00000316338Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganizat [...]
USP9X protein networkhttps://string-db.org/network/9606.ENSP00000316357Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulat [...]
DLGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000316377Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family.
CSH1 protein networkhttps://string-db.org/network/9606.ENSP00000316416Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR thr [...]
PACS1 protein networkhttps://string-db.org/network/9606.ENSP00000316454Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans- Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Contro [...]
DEGS1 protein networkhttps://string-db.org/network/9606.ENSP00000316476Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine). Belongs to the fatty acid desatur [...]
KCTD14 protein networkhttps://string-db.org/network/9606.ENSP00000316482BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14.
FCAMR protein networkhttps://string-db.org/network/9606.ENSP00000316491High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytos [...]
DCAF4L2 protein networkhttps://string-db.org/network/9606.ENSP00000316496DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2.
TLK2 protein networkhttps://string-db.org/network/9606.ENSP00000316512Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromos [...]
OR9A2 protein networkhttps://string-db.org/network/9606.ENSP00000316518Olfactory receptor 9A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF609 protein networkhttps://string-db.org/network/9606.ENSP00000316527Zinc finger protein 609; Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with N [...]
RAPH1 protein networkhttps://string-db.org/network/9606.ENSP00000316543Ras-associated and pleckstrin homology domains-containing protein 1; Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhe [...]
SUZ12 protein networkhttps://string-db.org/network/9606.ENSP00000316578Polycomb protein SUZ12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional re [...]
RANBP10 protein networkhttps://string-db.org/network/9606.ENSP00000316589Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex t [...]
GTPBP6 protein networkhttps://string-db.org/network/9606.ENSP00000316598GTP binding protein 6.
CNGB3 protein networkhttps://string-db.org/network/9606.ENSP00000316605Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which le [...]
SWI5 protein networkhttps://string-db.org/network/9606.ENSP00000316609DNA repair protein SWI5 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.
RNF152 protein networkhttps://string-db.org/network/9606.ENSP00000316628E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and [...]
C3orf22 protein networkhttps://string-db.org/network/9606.ENSP00000316644Uncharacterized protein C3orf22; Chromosome 3 open reading frame 22.
OSBPL2 protein networkhttps://string-db.org/network/9606.ENSP00000316649Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma [...]
ACTL9 protein networkhttps://string-db.org/network/9606.ENSP00000316674Actin-like protein 9; Actin like 9.
PVRIG protein networkhttps://string-db.org/network/9606.ENSP00000316675Transmembrane protein PVRIG; Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T [...]
CEP295 protein networkhttps://string-db.org/network/9606.ENSP00000316681Centrosomal protein of 295 kDa; Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CEN [...]
RHOJ protein networkhttps://string-db.org/network/9606.ENSP00000316729Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its in [...]
LCE1D protein networkhttps://string-db.org/network/9606.ENSP00000316737Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum.
TMEM270 protein networkhttps://string-db.org/network/9606.ENSP00000316775Transmembrane protein 270.
BIN1 protein networkhttps://string-db.org/network/9606.ENSP00000316779Myc box-dependent-interacting protein 1; Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tub [...]
NBPF3 protein networkhttps://string-db.org/network/9606.ENSP00000316782Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family.
HSD11B2 protein networkhttps://string-db.org/network/9606.ENSP00000316786Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonse [...]
RTL3 protein networkhttps://string-db.org/network/9606.ENSP00000316794Retrotransposon Gag-like protein 3; May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
PITPNA protein networkhttps://string-db.org/network/9606.ENSP00000316809Phosphatidylinositol transfer protein alpha isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
SIX5 protein networkhttps://string-db.org/network/9606.ENSP00000316842Homeobox protein SIX5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCA [...]
ARHGEF4 protein networkhttps://string-db.org/network/9606.ENSP00000316845Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex [...]
GPM6B protein networkhttps://string-db.org/network/9606.ENSP00000316861Neuronal membrane glycoprotein M6-b; May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; th [...]
P3H2 protein networkhttps://string-db.org/network/9606.ENSP00000316881Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 [...]
SFXN1 protein networkhttps://string-db.org/network/9606.ENSP00000316905Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to [...]
SLC17A8 protein networkhttps://string-db.org/network/9606.ENSP00000316909Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...]
ACSS1 protein networkhttps://string-db.org/network/9606.ENSP00000316924Acetyl-coenzyme A synthetase 2-like, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much [...]
TMEM31 protein networkhttps://string-db.org/network/9606.ENSP00000316940Transmembrane protein 31.
CLK4 protein networkhttps://string-db.org/network/9606.ENSP00000316948Dual specificity protein kinase CLK4; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the sp [...]
MYEF2 protein networkhttps://string-db.org/network/9606.ENSP00000316950Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function a [...]
OR7A5 protein networkhttps://string-db.org/network/9606.ENSP00000316955Olfactory receptor 7A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TM6SF1 protein networkhttps://string-db.org/network/9606.ENSP00000317000Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family.
GCNT4 protein networkhttps://string-db.org/network/9606.ENSP00000317027Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. [...]
RMI1 protein networkhttps://string-db.org/network/9606.ENSP00000317039RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA [...]
SNRNP200 protein networkhttps://string-db.org/network/9606.ENSP00000317123U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome [...]
PLXND1 protein networkhttps://string-db.org/network/9606.ENSP00000317128Plexin-D1; Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wi [...]
PIBF1 protein networkhttps://string-db.org/network/9606.ENSP00000317144Progesterone-induced-blocking factor 1; Plays a role in ciliogenesis. [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with ar [...]
CYC1 protein networkhttps://string-db.org/network/9606.ENSP00000317159Cytochrome c1, heme protein, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain [...]
PLEKHD1 protein networkhttps://string-db.org/network/9606.ENSP00000317175Pleckstrin homology and coiled-coil domain containing D1; Belongs to the PLEKHD1 family.
PLD6 protein networkhttps://string-db.org/network/9606.ENSP00000317177Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the act [...]
CAPN6 protein networkhttps://string-db.org/network/9606.ENSP00000317214Calpain-6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interactio [...]
SAMD4B protein networkhttps://string-db.org/network/9606.ENSP00000317224Protein Smaug homolog 2; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A. Belongs to the SMAUG family.
FKBP10 protein networkhttps://string-db.org/network/9606.ENSP00000317232Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis.
CPNE1 protein networkhttps://string-db.org/network/9606.ENSP00000317257Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium- dependen [...]
MET protein networkhttps://string-db.org/network/9606.ENSP00000317272Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates m [...]
FAM220A protein networkhttps://string-db.org/network/9606.ENSP00000317289Protein FAM220A; May negatively regulate STAT3.
LPCAT4 protein networkhttps://string-db.org/network/9606.ENSP00000317300Lysophospholipid acyltransferase LPCAT4; Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolam [...]
CABP1 protein networkhttps://string-db.org/network/9606.ENSP00000317310Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist- induced intracellular calcium signaling. Enhances inactivation [...]
UBASH3A protein networkhttps://string-db.org/network/9606.ENSP00000317327Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target [...]
SSR4 protein networkhttps://string-db.org/network/9606.ENSP00000317331Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; B [...]
NEUROG2 protein networkhttps://string-db.org/network/9606.ENSP00000317333Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3').
TCP1 protein networkhttps://string-db.org/network/9606.ENSP00000317334T-complex protein 1 subunit alpha; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC comple [...]
OR13D1 protein networkhttps://string-db.org/network/9606.ENSP00000317357Olfactory receptor 13D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MRPS11 protein networkhttps://string-db.org/network/9606.ENSP00000317376Mitochondrial ribosomal protein S11.
GLS protein networkhttps://string-db.org/network/9606.ENSP00000317379Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasi [...]
SLC36A4 protein networkhttps://string-db.org/network/9606.ENSP00000317382Proton-coupled amino acid transporter 4; Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine. Belongs to the amino acid/polyam [...]
CHST13 protein networkhttps://string-db.org/network/9606.ENSP00000317404Carbohydrate sulfotransferase 13; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant pr [...]
ENTHD1 protein networkhttps://string-db.org/network/9606.ENSP00000317431ENTH domain containing 1.
CNPY1 protein networkhttps://string-db.org/network/9606.ENSP00000317439Canopy FGF signaling regulator 1; Belongs to the canopy family.
PSAPL1 protein networkhttps://string-db.org/network/9606.ENSP00000317445Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids.
CHMP6 protein networkhttps://string-db.org/network/9606.ENSP00000317468Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
BBS1 protein networkhttps://string-db.org/network/9606.ENSP00000317469Bardet-Biedl syndrome 1 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...]
RABGGTB protein networkhttps://string-db.org/network/9606.ENSP00000317473Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -X [...]
OR4F4 protein networkhttps://string-db.org/network/9606.ENSP00000317482Olfactory receptor 4F4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
EID2B protein networkhttps://string-db.org/network/9606.ENSP00000317564EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation.
GRK3 protein networkhttps://string-db.org/network/9606.ENSP00000317578Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors; Belongs to the protein kinase superfamily. AGC Ser/T [...]
C16orf58 protein networkhttps://string-db.org/network/9606.ENSP00000317579RUS1 family protein C16orf58.
NEUROG1 protein networkhttps://string-db.org/network/9606.ENSP00000317580Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromati [...]
TPPP2 protein networkhttps://string-db.org/network/9606.ENSP00000317595Tubulin polymerization-promoting protein family member 2; Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no mic [...]
ZNF518B protein networkhttps://string-db.org/network/9606.ENSP00000317614Zinc finger protein 518B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RECQL5 protein networkhttps://string-db.org/network/9606.ENSP00000317636ATP-dependent DNA helicase Q5; Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage s [...]
C12orf40 protein networkhttps://string-db.org/network/9606.ENSP00000317671Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40.
APOL1 protein networkhttps://string-db.org/network/9606.ENSP00000317674Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver.
ZFP42 protein networkhttps://string-db.org/network/9606.ENSP00000317686Zinc finger protein 42 homolog; Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA anti [...]
RPP25 protein networkhttps://string-db.org/network/9606.ENSP00000317691Ribonuclease P protein subunit p25; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclea [...]
STX4 protein networkhttps://string-db.org/network/9606.ENSP00000317714Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 [...]
PIPOX protein networkhttps://string-db.org/network/9606.ENSP00000317721Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline.
HARBI1 protein networkhttps://string-db.org/network/9606.ENSP00000317743Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.
COX5A protein networkhttps://string-db.org/network/9606.ENSP00000317780Cytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
SPTBN5 protein networkhttps://string-db.org/network/9606.ENSP00000317790Spectrin beta, non-erythrocytic 5.
SH2D3C protein networkhttps://string-db.org/network/9606.ENSP00000317817SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-depende [...]
PRR15 protein networkhttps://string-db.org/network/9606.ENSP00000317836Proline-rich protein 15; May have a role in proliferation and/or differentiation.
RBBP6 protein networkhttps://string-db.org/network/9606.ENSP00000317872E3 ubiquitin-protein ligase RBBP6; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promot [...]
TNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000317891TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B- dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link [...]
RPTN protein networkhttps://string-db.org/network/9606.ENSP00000317895Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.
CEP57 protein networkhttps://string-db.org/network/9606.ENSP00000317902Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear t [...]
GYS1 protein networkhttps://string-db.org/network/9606.ENSP00000317904Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.
EEA1 protein networkhttps://string-db.org/network/9606.ENSP00000317955Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
WDTC1 protein networkhttps://string-db.org/network/9606.ENSP00000317971WD and tetratricopeptide repeats protein 1; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
ROCK2 protein networkhttps://string-db.org/network/9606.ENSP00000317985Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organizat [...]
NOC2L protein networkhttps://string-db.org/network/9606.ENSP00000317992Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53- [...]
DUOX1 protein networkhttps://string-db.org/network/9606.ENSP00000317997Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-me [...]
WASHC5 protein networkhttps://string-db.org/network/9606.ENSP00000318016WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...]
ODF3L2 protein networkhttps://string-db.org/network/9606.ENSP00000318029Outer dense fiber of sperm tails 3 like 2.
RPRML protein networkhttps://string-db.org/network/9606.ENSP00000318032Reprimo-like protein; Reprimo like.
EGR3 protein networkhttps://string-db.org/network/9606.ENSP00000318057Early growth response protein 3; Probable transcription factor involved in muscle spindle development; Belongs to the EGR C2H2-type zinc-finger protein family.
ENPP4 protein networkhttps://string-db.org/network/9606.ENSP00000318066Bis(5'-adenosyl)-triphosphatase ENPP4; Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of v [...]
HINFP protein networkhttps://string-db.org/network/9606.ENSP00000318085Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene tra [...]
MAP7D3 protein networkhttps://string-db.org/network/9606.ENSP00000318086MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules.
SCMH1 protein networkhttps://string-db.org/network/9606.ENSP00000318094Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes.
CLDN22 protein networkhttps://string-db.org/network/9606.ENSP00000318113Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
BLOC1S4 protein networkhttps://string-db.org/network/9606.ENSP00000318128Biogenesis of lysosome-related organelles complex 1 subunit 4; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
PNMA8A protein networkhttps://string-db.org/network/9606.ENSP00000318131Paraneoplastic antigen-like protein 8A; PNMA family member 8A.
FUT7 protein networkhttps://string-db.org/network/9606.ENSP00000318142Alpha-(1,3)-fucosyltransferase 7; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine [...]
EDEM3 protein networkhttps://string-db.org/network/9606.ENSP00000318147ER degradation-enhancing alpha-mannosidase-like protein 3; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose [...]
MRFAP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000318154Morf4 family associated protein 1 like 1.
MRPS24 protein networkhttps://string-db.org/network/9606.ENSP00000318158Mitochondrial ribosomal protein S24; Belongs to the universal ribosomal protein uS3 family.
OS9 protein networkhttps://string-db.org/network/9606.ENSP00000318165Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as imprope [...]
PRKRA protein networkhttps://string-db.org/network/9606.ENSP00000318176Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha [...]
FUBP3 protein networkhttps://string-db.org/network/9606.ENSP00000318177Far upstream element-binding protein 3; May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.
NCL protein networkhttps://string-db.org/network/9606.ENSP00000318195Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensat [...]
TUBA3E protein networkhttps://string-db.org/network/9606.ENSP00000318197Detyrosinated tubulin alpha-3E chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site [...]
ZDHHC22 protein networkhttps://string-db.org/network/9606.ENSP00000318222Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. Might also mediate palmitoylation of CNN3 (By [...]
COL26A1 protein networkhttps://string-db.org/network/9606.ENSP00000318234Collagen type XXVI alpha 1 chain.
CSRNP3 protein networkhttps://string-db.org/network/9606.ENSP00000318258Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).
PROM2 protein networkhttps://string-db.org/network/9606.ENSP00000318270Prominin-2; Prominin 2.
RUVBL1 protein networkhttps://string-db.org/network/9606.ENSP00000318297RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits [...]
TENT5A protein networkhttps://string-db.org/network/9606.ENSP00000318298Terminal nucleotidyltransferase 5A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase.
MPI protein networkhttps://string-db.org/network/9606.ENSP00000318318Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the mannose-6 [...]
BCKDHB protein networkhttps://string-db.org/network/9606.ENSP000003183512-oxoisovalerate dehydrogenase subunit beta, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It cont [...]
MRFAP1 protein networkhttps://string-db.org/network/9606.ENSP00000318352Morf4 family associated protein 1.
AQP10 protein networkhttps://string-db.org/network/9606.ENSP00000318355Aquaporin-10; [Isoform 1]: Water channel that mediates water transport across cell membranes irrespective of the cytosolic pH. The channel is permeable to glycerol, especially when the cytosolic [...]
ZNF513 protein networkhttps://string-db.org/network/9606.ENSP00000318373Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance.
LENG8 protein networkhttps://string-db.org/network/9606.ENSP00000318374Leukocyte receptor cluster member 8.
KIAA0319L protein networkhttps://string-db.org/network/9606.ENSP00000318406Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R.
LINS1 protein networkhttps://string-db.org/network/9606.ENSP00000318423Lines homolog 1.
CCDC114 protein networkhttps://string-db.org/network/9606.ENSP00000318429Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family [...]
FDCSP protein networkhttps://string-db.org/network/9606.ENSP00000318437Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.
YME1L1 protein networkhttps://string-db.org/network/9606.ENSP00000318480ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial interm [...]
CDK5R1 protein networkhttps://string-db.org/network/9606.ENSP00000318486Cyclin-dependent kinase 5 activator 1, p25; p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine [...]
BACE1 protein networkhttps://string-db.org/network/9606.ENSP00000318585Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, [...]
PRTFDC1 protein networkhttps://string-db.org/network/9606.ENSP00000318602Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) [...]
MAF1 protein networkhttps://string-db.org/network/9606.ENSP00000318604Repressor of RNA polymerase III transcription MAF1 homolog; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cell [...]
LDLRAD3 protein networkhttps://string-db.org/network/9606.ENSP00000318607Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide product [...]
TRIM73 protein networkhttps://string-db.org/network/9606.ENSP00000318615Tripartite motif containing 73; Belongs to the TRIM/RBCC family.
VPS37A protein networkhttps://string-db.org/network/9606.ENSP00000318629Vacuolar protein sorting-associated protein 37A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...]
SUMO4 protein networkhttps://string-db.org/network/9606.ENSP00000318635Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate pr [...]
INTS3 protein networkhttps://string-db.org/network/9606.ENSP00000318641Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent [...]
RPS15A protein networkhttps://string-db.org/network/9606.ENSP0000031864640S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis.
GREM2 protein networkhttps://string-db.org/network/9606.ENSP00000318650Gremlin-2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morph [...]
VSIG2 protein networkhttps://string-db.org/network/9606.ENSP00000318684V-set and immunoglobulin domain containing 2.
GCFC2 protein networkhttps://string-db.org/network/9606.ENSP00000318690GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calc [...]
TUBB6 protein networkhttps://string-db.org/network/9606.ENSP00000318697Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...]
FAM9B protein networkhttps://string-db.org/network/9606.ENSP00000318716Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family.
AQP11 protein networkhttps://string-db.org/network/9606.ENSP00000318770Aquaporin-11; Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organ [...]
BHLHE22 protein networkhttps://string-db.org/network/9606.ENSP00000318799Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, pro [...]
SYTL2 protein networkhttps://string-db.org/network/9606.ENSP00000318803Synaptotagmin-like protein 2; Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immu [...]
CRLF3 protein networkhttps://string-db.org/network/9606.ENSP00000318804Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression.
GCC1 protein networkhttps://string-db.org/network/9606.ENSP00000318821GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure.
BID protein networkhttps://string-db.org/network/9606.ENSP00000318822BH3-interacting domain death agonist p11; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases an [...]
OR10H4 protein networkhttps://string-db.org/network/9606.ENSP00000318834Olfactory receptor 10H4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SF3B2 protein networkhttps://string-db.org/network/9606.ENSP00000318861Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...]
CYP8B1 protein networkhttps://string-db.org/network/9606.ENSP000003188677-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha- dihydrox [...]
SHMT1 protein networkhttps://string-db.org/network/9606.ENSP00000318868Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine.
OR4F21 protein networkhttps://string-db.org/network/9606.ENSP00000318878Olfactory receptor 4F21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FMN2 protein networkhttps://string-db.org/network/9606.ENSP00000318884Formin-2; Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE [...]
SOBP protein networkhttps://string-db.org/network/9606.ENSP00000318900Sine oculis-binding protein homolog; Implicated in development of the cochlea.
CA13 protein networkhttps://string-db.org/network/9606.ENSP00000318912Carbonic anhydrase 13; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family.
PNMA1 protein networkhttps://string-db.org/network/9606.ENSP00000318914Paraneoplastic antigen Ma1; PNMA family member 1; Belongs to the PNMA family.
MARCO protein networkhttps://string-db.org/network/9606.ENSP00000318916Macrophage receptor MARCO; Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages ( [...]
TRAF7 protein networkhttps://string-db.org/network/9606.ENSP00000318944E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and D [...]
OR52K2 protein networkhttps://string-db.org/network/9606.ENSP00000318956Olfactory receptor 52K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SLC35C2 protein networkhttps://string-db.org/network/9606.ENSP00000318960Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a f [...]
PINX1 protein networkhttps://string-db.org/network/9606.ENSP00000318966PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 bindin [...]
FAM133A protein networkhttps://string-db.org/network/9606.ENSP00000318974Protein FAM133A; Family with sequence similarity 133 member A.
EPSTI1 protein networkhttps://string-db.org/network/9606.ENSP00000318982Epithelial-stromal interaction protein 1; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (B [...]
NSUN3 protein networkhttps://string-db.org/network/9606.ENSP00000318986tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial; Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt- tRNA(Met). mt [...]
OR11H4 protein networkhttps://string-db.org/network/9606.ENSP00000318997Olfactory receptor 11H4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
C11orf16 protein networkhttps://string-db.org/network/9606.ENSP00000318999Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16.
CCDC71 protein networkhttps://string-db.org/network/9606.ENSP00000319006Coiled-coil domain containing 71.
CETN1 protein networkhttps://string-db.org/network/9606.ENSP00000319052Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function. Plays a role in sperm cilia formation (By similarity).
ZNF77 protein networkhttps://string-db.org/network/9606.ENSP00000319053Zinc finger protein 77; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CAMK2G protein networkhttps://string-db.org/network/9606.ENSP00000319060Calcium/calmodulin-dependent protein kinase type II subunit gamma; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, [...]
OR11H6 protein networkhttps://string-db.org/network/9606.ENSP00000319071Olfactory receptor 11H6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RAP2B protein networkhttps://string-db.org/network/9606.ENSP00000319096Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of P [...]
SUPT6H protein networkhttps://string-db.org/network/9606.ENSP00000319104Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the t [...]
GSX2 protein networkhttps://string-db.org/network/9606.ENSP00000319118GS homeobox 2; During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, neces [...]
DEFB112 protein networkhttps://string-db.org/network/9606.ENSP00000319126Beta-defensin 112; Has antibacterial activity; Belongs to the beta-defensin family.
PSG11 protein networkhttps://string-db.org/network/9606.ENSP00000319140Pregnancy specific beta-1-glycoprotein 11.
CYBRD1 protein networkhttps://string-db.org/network/9606.ENSP00000319141Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating [...]
PRMT5 protein networkhttps://string-db.org/network/9606.ENSP00000319169Protein arginine N-methyltransferase 5, N-terminally processed; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginin [...]
DHFR2 protein networkhttps://string-db.org/network/9606.ENSP00000319170Dihydrofolate reductase 2, mitochondrial; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mt [...]
KDF1 protein networkhttps://string-db.org/network/9606.ENSP00000319179Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter [...]
STK17A protein networkhttps://string-db.org/network/9606.ENSP00000319192Serine/threonine-protein kinase 17A; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species. Belongs to the protein kinase superfamily. CAMK Ser/T [...]
OR4K17 protein networkhttps://string-db.org/network/9606.ENSP00000319197Olfactory receptor 4K17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4L1 protein networkhttps://string-db.org/network/9606.ENSP00000319217Olfactory receptor 4L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF720 protein networkhttps://string-db.org/network/9606.ENSP00000319222Putative protein ZNF720; Zinc finger protein 720.
PHLDA2 protein networkhttps://string-db.org/network/9606.ENSP00000319231Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing [...]
MAGOHB protein networkhttps://string-db.org/network/9606.ENSP00000319240Protein mago nashi homolog 2; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NM [...]
GPR62 protein networkhttps://string-db.org/network/9606.ENSP00000319250G-protein coupled receptor 62; Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for [...]
CHORDC1 protein networkhttps://string-db.org/network/9606.ENSP00000319255Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play [...]
BASP1 protein networkhttps://string-db.org/network/9606.ENSP00000319281Brain abundant membrane attached signal protein 1; Belongs to the BASP1 family.
ZNF572 protein networkhttps://string-db.org/network/9606.ENSP00000319305Zinc finger protein 572; May be involved in transcriptional regulation.
LSM10 protein networkhttps://string-db.org/network/9606.ENSP00000319341U7 snRNA-associated Sm-like protein LSm10; Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA pro [...]
KCNMB3 protein networkhttps://string-db.org/network/9606.ENSP00000319370Calcium-activated potassium channel subunit beta-3; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...]
MAMDC4 protein networkhttps://string-db.org/network/9606.ENSP00000319388Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia.
ARMC10 protein networkhttps://string-db.org/network/9606.ENSP00000319412Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53.
SKA3 protein networkhttps://string-db.org/network/9606.ENSP00000319417Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA [...]
CPN2 protein networkhttps://string-db.org/network/9606.ENSP00000319464Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric mod [...]
ICOS protein networkhttps://string-db.org/network/9606.ENSP00000319476Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interact [...]
DCUN1D3 protein networkhttps://string-db.org/network/9606.ENSP00000319482DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like c [...]
TSPAN16 protein networkhttps://string-db.org/network/9606.ENSP00000319486Tetraspanin-16; Tetraspanin 16.
UGDH protein networkhttps://string-db.org/network/9606.ENSP00000319501UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulf [...]
OR4K5 protein networkhttps://string-db.org/network/9606.ENSP00000319511Olfactory receptor 4K5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GCSH protein networkhttps://string-db.org/network/9606.ENSP00000319531Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P prote [...]
OR2A4 protein networkhttps://string-db.org/network/9606.ENSP00000319546Olfactory receptor 2A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PRR18 protein networkhttps://string-db.org/network/9606.ENSP00000319590Proline-rich protein 18; Proline rich 18.
KCND3 protein networkhttps://string-db.org/network/9606.ENSP00000319591Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I( [...]
SNAPC5 protein networkhttps://string-db.org/network/9606.ENSP00000319597snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...]
SULT1C2 protein networkhttps://string-db.org/network/9606.ENSP00000319622Sulfotransferase 1C2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neu [...]
IGDCC4 protein networkhttps://string-db.org/network/9606.ENSP00000319623Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family.
CXCR2 protein networkhttps://string-db.org/network/9606.ENSP00000319635C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is m [...]
B3GNT4 protein networkhttps://string-db.org/network/9606.ENSP00000319636N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosacc [...]
DMRTA1 protein networkhttps://string-db.org/network/9606.ENSP00000319651Doublesex- and mab-3-related transcription factor A1; DMRT like family A1; Belongs to the DMRT family.
NUDC protein networkhttps://string-db.org/network/9606.ENSP00000319664Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. [...]
GPR89A protein networkhttps://string-db.org/network/9606.ENSP00000319673Golgi pH regulator A; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance; Belongs to the Golgi pH regulat [...]
DUOXA2 protein networkhttps://string-db.org/network/9606.ENSP00000319705Dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synth [...]
AGTRAP protein networkhttps://string-db.org/network/9606.ENSP00000319713Type-1 angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechan [...]
FRMD8 protein networkhttps://string-db.org/network/9606.ENSP00000319726FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involve [...]
PRSS8 protein networkhttps://string-db.org/network/9606.ENSP00000319730Prostasin heavy chain; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage [...]
RCN2 protein networkhttps://string-db.org/network/9606.ENSP00000319739Reticulocalbin-2; Not known. Binds calcium.
GPR4 protein networkhttps://string-db.org/network/9606.ENSP00000319744G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production.
TNS2 protein networkhttps://string-db.org/network/9606.ENSP00000319756Tensin-2; Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its [...]
RAB43 protein networkhttps://string-db.org/network/9606.ENSP00000319781Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
NQO1 protein networkhttps://string-db.org/network/9606.ENSP00000319788NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in b [...]
SERINC4 protein networkhttps://string-db.org/network/9606.ENSP00000319796Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids.
H1-8 protein networkhttps://string-db.org/network/9606.ENSP00000319799Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic mat [...]
PCK1 protein networkhttps://string-db.org/network/9606.ENSP00000319814Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low gluco [...]
OPA3 protein networkhttps://string-db.org/network/9606.ENSP00000319817Outer mitochondrial membrane lipid metabolism regulator OPA3.
ZNF687 protein networkhttps://string-db.org/network/9606.ENSP00000319829Zinc finger protein 687; May be involved in transcriptional regulation.
DEF6 protein networkhttps://string-db.org/network/9606.ENSP00000319831Differentially expressed in FDCP 6 homolog; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, R [...]
SLURP2 protein networkhttps://string-db.org/network/9606.ENSP00000319846Secreted Ly-6/uPAR domain-containing protein 2; Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, dif [...]
CHDH protein networkhttps://string-db.org/network/9606.ENSP00000319851Choline dehydrogenase, mitochondrial; Choline dehydrogenase.
ADGRE2 protein networkhttps://string-db.org/network/9606.ENSP00000319883Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxi [...]
TCIM protein networkhttps://string-db.org/network/9606.ENSP00000319914Transcriptional and immune response regulator; Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type [...]
ITFG1 protein networkhttps://string-db.org/network/9606.ENSP00000319918T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family.
BBX protein networkhttps://string-db.org/network/9606.ENSP00000319974HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase.
B3GNTL1 protein networkhttps://string-db.org/network/9606.ENSP00000319979UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; Putative glycosyltransferase; Belongs to the glycosyltransferase 2 family.
SLC16A6 protein networkhttps://string-db.org/network/9606.ENSP00000319991Monocarboxylate transporter 7; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...]
TMEM11 protein networkhttps://string-db.org/network/9606.ENSP00000319992Transmembrane protein 11, mitochondrial; Plays a role in mitochondrial morphogenesis. Belongs to the TMEM11 family.
MPDZ protein networkhttps://string-db.org/network/9606.ENSP00000320006Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR p [...]
PHYHIP protein networkhttps://string-db.org/network/9606.ENSP00000320017Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system.
CACNB2 protein networkhttps://string-db.org/network/9606.ENSP00000320025Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...]
ARHGAP33 protein networkhttps://string-db.org/network/9606.ENSP00000320038Rho GTPase-activating protein 33; May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a down [...]
LYPLA1 protein networkhttps://string-db.org/network/9606.ENSP00000320043Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low l [...]
OR4D11 protein networkhttps://string-db.org/network/9606.ENSP00000320077Olfactory receptor 4D11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DIPK2A protein networkhttps://string-db.org/network/9606.ENSP00000320081Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIPK family.
CD276 protein networkhttps://string-db.org/network/9606.ENSP00000320084CD276 antigen; May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role o [...]
NKX2-6 protein networkhttps://string-db.org/network/9606.ENSP00000320089Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.
SH3GL3 protein networkhttps://string-db.org/network/9606.ENSP00000320092Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity).
ZNF784 protein networkhttps://string-db.org/network/9606.ENSP00000320096Zinc finger protein 784; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TRIP10 protein networkhttps://string-db.org/network/9606.ENSP00000320117Cdc42-interacting protein 4; Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganiz [...]
DYNC1I1 protein networkhttps://string-db.org/network/9606.ENSP00000320130Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargo [...]
EZH2 protein networkhttps://string-db.org/network/9606.ENSP00000320147Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, lead [...]
PKM protein networkhttps://string-db.org/network/9606.ENSP00000320171Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activati [...]
HCLS1 protein networkhttps://string-db.org/network/9606.ENSP00000320176Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lympho [...]
GHRHR protein networkhttps://string-db.org/network/9606.ENSP00000320180Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growt [...]
MRPS23 protein networkhttps://string-db.org/network/9606.ENSP00000320184Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family.
ZNF579 protein networkhttps://string-db.org/network/9606.ENSP00000320188Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CIDEA protein networkhttps://string-db.org/network/9606.ENSP00000320209Cell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS [...]
SLC26A10 protein networkhttps://string-db.org/network/9606.ENSP00000320217Solute carrier family 26 member 10; Chloride/bicarbonate exchanger.
ARSJ protein networkhttps://string-db.org/network/9606.ENSP00000320219Arylsulfatase family member J.
CCDC168 protein networkhttps://string-db.org/network/9606.ENSP00000320232Coiled-coil domain containing 168.
TIMM22 protein networkhttps://string-db.org/network/9606.ENSP00000320236Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins [...]
SLC9A9 protein networkhttps://string-db.org/network/9606.ENSP00000320246Sodium/hydrogen exchanger 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved i [...]
AQP6 protein networkhttps://string-db.org/network/9606.ENSP00000320247Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism.
NEPRO protein networkhttps://string-db.org/network/9606.ENSP00000320251Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibi [...]
OSBPL1A protein networkhttps://string-db.org/network/9606.ENSP00000320291Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP [...]
TUBB3 protein networkhttps://string-db.org/network/9606.ENSP00000320295Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...]
FARSA protein networkhttps://string-db.org/network/9606.ENSP00000320309phenylalanyl-tRNA synthetase subunit alpha.
NEU4 protein networkhttps://string-db.org/network/9606.ENSP00000320318Sialidase-4; May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic [...]
NPEPPS protein networkhttps://string-db.org/network/9606.ENSP00000320324Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regula [...]
PLAAT3 protein networkhttps://string-db.org/network/9606.ENSP00000320337Phospholipase A and acyltransferase 3; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent re [...]
ELL3 protein networkhttps://string-db.org/network/9606.ENSP00000320346RNA polymerase II elongation factor ELL3; Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future act [...]
ZFP3 protein networkhttps://string-db.org/network/9606.ENSP00000320347Zinc finger protein 3 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
IFT22 protein networkhttps://string-db.org/network/9606.ENSP00000320359Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family.
P2RY13 protein networkhttps://string-db.org/network/9606.ENSP00000320376P2Y purinoceptor 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
SLC7A8 protein networkhttps://string-db.org/network/9606.ENSP00000320378Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalani [...]
UGT2B17 protein networkhttps://string-db.org/network/9606.ENSP00000320401UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of thi [...]
VPS37D protein networkhttps://string-db.org/network/9606.ENSP00000320416Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...]
S100Z protein networkhttps://string-db.org/network/9606.ENSP00000320430S100 calcium binding protein Z; Belongs to the S-100 family.
ST8SIA3 protein networkhttps://string-db.org/network/9606.ENSP00000320431Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alp [...]
CTNNAL1 protein networkhttps://string-db.org/network/9606.ENSP00000320434Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
ARID1A protein networkhttps://string-db.org/network/9606.ENSP00000320485AT-rich interactive domain-containing protein 1A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component [...]
NAP1L5 protein networkhttps://string-db.org/network/9606.ENSP00000320488Nucleosome assembly protein 1 like 5.
RNF185 protein networkhttps://string-db.org/network/9606.ENSP00000320508E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic [...]
BANK1 protein networkhttps://string-db.org/network/9606.ENSP00000320509B-cell scaffold protein with ankyrin repeats; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and [...]
LRRC75B protein networkhttps://string-db.org/network/9606.ENSP00000320520Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B.
FAM3A protein networkhttps://string-db.org/network/9606.ENSP00000320521Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family.
WFDC9 protein networkhttps://string-db.org/network/9606.ENSP00000320532Protein WFDC9; WAP four-disulfide core domain 9.
EPN2 protein networkhttps://string-db.org/network/9606.ENSP00000320543Epsin-2; Plays a role in the formation of clathrin-coated invaginations and endocytosis; Belongs to the epsin family.
DNAJC4 protein networkhttps://string-db.org/network/9606.ENSP00000320548DnaJ heat shock protein family member C4.
OR2D3 protein networkhttps://string-db.org/network/9606.ENSP00000320560Olfactory receptor 2D3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
WDFY4 protein networkhttps://string-db.org/network/9606.ENSP00000320563WD repeat- and FYVE domain-containing protein 4; Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts [...]
ING3 protein networkhttps://string-db.org/network/9606.ENSP00000320566Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleoso [...]
MRPS33 protein networkhttps://string-db.org/network/9606.ENSP00000320567Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family.
FAXDC2 protein networkhttps://string-db.org/network/9606.ENSP00000320604Fatty acid hydroxylase domain-containing protein 2; Promotes megakaryocyte differentiation by enhancing ERK phosphorylation and up-regulating RUNX1 expression.
SLCO3A1 protein networkhttps://string-db.org/network/9606.ENSP00000320634Solute carrier organic anion transporter family member 3A1; Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate. Mediates transport of prostaglandins (PG) E1 and [...]
WDR97 protein networkhttps://string-db.org/network/9606.ENSP00000320648WD repeat domain 97.
CCDC89 protein networkhttps://string-db.org/network/9606.ENSP00000320649Coiled-coil domain containing 89; Belongs to the CCDC89 family.
DNAJC25 protein networkhttps://string-db.org/network/9606.ENSP00000320650DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family.
YARS2 protein networkhttps://string-db.org/network/9606.ENSP00000320658Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acc [...]
EML4 protein networkhttps://string-db.org/network/9606.ENSP00000320663Echinoderm microtubule-associated protein-like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP fam [...]
STX19 protein networkhttps://string-db.org/network/9606.ENSP00000320679Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR); Belongs to the syntaxin family.
SLC25A36 protein networkhttps://string-db.org/network/9606.ENSP00000320688Solute carrier family 25 member 36; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleosi [...]
TMEM150B protein networkhttps://string-db.org/network/9606.ENSP00000320757Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes [...]
USF3 protein networkhttps://string-db.org/network/9606.ENSP00000320794Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhe [...]
TUBD1 protein networkhttps://string-db.org/network/9606.ENSP00000320797Tubulin delta chain; Acts as a positive regulator of hedgehog signaling and regulates ciliary function; Belongs to the tubulin family.
DEFB104A protein networkhttps://string-db.org/network/9606.ENSP00000320813Beta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family.
GDPD4 protein networkhttps://string-db.org/network/9606.ENSP00000320815Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family.
KIF1C protein networkhttps://string-db.org/network/9606.ENSP00000320821Kinesin-like protein KIF1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility.
CCDC184 protein networkhttps://string-db.org/network/9606.ENSP00000320849Coiled-coil domain containing 184.
CALR protein networkhttps://string-db.org/network/9606.ENSP00000320866Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts [...]
TRIM41 protein networkhttps://string-db.org/network/9606.ENSP00000320869E3 ubiquitin-protein ligase TRIM41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. Belongs to the TRIM/RBCC family.
SPAST protein networkhttps://string-db.org/network/9606.ENSP00000320885Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with [...]
MLXIPL protein networkhttps://string-db.org/network/9606.ENSP00000320886Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity).
RNF168 protein networkhttps://string-db.org/network/9606.ENSP00000320898E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ub [...]
WIPF2 protein networkhttps://string-db.org/network/9606.ENSP00000320924WAS/WASL-interacting protein family member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspik [...]
SLC2A4 protein networkhttps://string-db.org/network/9606.ENSP00000320935Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to i [...]
IL17RA protein networkhttps://string-db.org/network/9606.ENSP00000320936Interleukin-17 receptor A; Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17 [...]
CNOT1 protein networkhttps://string-db.org/network/9606.ENSP00000320949CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including [...]
DEFB103A protein networkhttps://string-db.org/network/9606.ENSP00000320951Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresi [...]
VGLL2 protein networkhttps://string-db.org/network/9606.ENSP00000320957Transcription cofactor vestigial-like protein 2; May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles; Belongs to the vestigial family.
CD300LG protein networkhttps://string-db.org/network/9606.ENSP00000321005CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity).
C11orf42 protein networkhttps://string-db.org/network/9606.ENSP00000321021Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42.
LURAP1L protein networkhttps://string-db.org/network/9606.ENSP00000321026Leucine rich adaptor protein 1 like.
TMEM86B protein networkhttps://string-db.org/network/9606.ENSP00000321038Lysoplasmalogenase; Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the [...]
ME2 protein networkhttps://string-db.org/network/9606.ENSP00000321070NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family.
SIGLEC8 protein networkhttps://string-db.org/network/9606.ENSP00000321077Sialic acid-binding Ig-like lectin 8; Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds t [...]
TAC1 protein networkhttps://string-db.org/network/9606.ENSP00000321106C-terminal-flanking peptide; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) man [...]
SPOCK2 protein networkhttps://string-db.org/network/9606.ENSP00000321108Testican-2; May participate in diverse steps of neurogenesis. Binds calcium.
ZNF554 protein networkhttps://string-db.org/network/9606.ENSP00000321132Zinc finger protein 554; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RBM44 protein networkhttps://string-db.org/network/9606.ENSP00000321179RNA-binding protein 44; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for [...]
ATP11B protein networkhttps://string-db.org/network/9606.ENSP00000321195Probable phospholipid-transporting ATPase IF; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...]
OR56B4 protein networkhttps://string-db.org/network/9606.ENSP00000321196Olfactory receptor 56B4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TNIP2 protein networkhttps://string-db.org/network/9606.ENSP00000321203TNFAIP3-interacting protein 2; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appea [...]
SH2B1 protein networkhttps://string-db.org/network/9606.ENSP00000321221SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine ki [...]
RCHY1 protein networkhttps://string-db.org/network/9606.ENSP00000321239RING finger and CHY zinc finger domain-containing protein 1; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Prefer [...]
OR56A1 protein networkhttps://string-db.org/network/9606.ENSP00000321246Olfactory receptor 56A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SIGLECL1 protein networkhttps://string-db.org/network/9606.ENSP00000321249SIGLEC family like 1.
TALDO1 protein networkhttps://string-db.org/network/9606.ENSP00000321259Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
COX8A protein networkhttps://string-db.org/network/9606.ENSP00000321260Cytochrome c oxidase subunit 8A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
PXMP2 protein networkhttps://string-db.org/network/9606.ENSP00000321271Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.
VCX2 protein networkhttps://string-db.org/network/9606.ENSP00000321309Variable charge X-linked protein 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family.
HGH1 protein networkhttps://string-db.org/network/9606.ENSP00000321320HGH1 homolog; Belongs to the HGH1 family.
F2R protein networkhttps://string-db.org/network/9606.ENSP00000321326Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vas [...]
RNF144A protein networkhttps://string-db.org/network/9606.ENSP00000321330E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly trans [...]
LPA protein networkhttps://string-db.org/network/9606.ENSP00000321334Apolipoprotein(a); Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) [...]
OR4C5 protein networkhttps://string-db.org/network/9606.ENSP00000321338Olfactory receptor 4C5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IL23R protein networkhttps://string-db.org/network/9606.ENSP00000321345Interleukin-23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably [...]
TTLL11 protein networkhttps://string-db.org/network/9606.ENSP00000321346Tubulin polyglutamylase TTLL11; Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiati [...]
STRBP protein networkhttps://string-db.org/network/9606.ENSP00000321347Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently [...]
DIAPH2 protein networkhttps://string-db.org/network/9606.ENSP00000321348Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are se [...]
C14orf177 protein networkhttps://string-db.org/network/9606.ENSP00000321360Putative uncharacterized protein C14orf177; Chromosome 14 putative open reading frame 177.
ZBED2 protein networkhttps://string-db.org/network/9606.ENSP00000321370Zinc finger BED-type containing 2.
FBXO39 protein networkhttps://string-db.org/network/9606.ENSP00000321386F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
ASB4 protein networkhttps://string-db.org/network/9606.ENSP00000321388Ankyrin repeat and SOCS box protein 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
SLC34A1 protein networkhttps://string-db.org/network/9606.ENSP00000321424Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the a [...]
KCNH5 protein networkhttps://string-db.org/network/9606.ENSP00000321427Potassium voltage-gated channel subfamily H member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties ma [...]
MSC protein networkhttps://string-db.org/network/9606.ENSP00000321445Musculin; Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation.
OR4S1 protein networkhttps://string-db.org/network/9606.ENSP00000321447Olfactory receptor 4S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RRP7A protein networkhttps://string-db.org/network/9606.ENSP00000321449Ribosomal RNA processing 7 homolog A.
MICU3 protein networkhttps://string-db.org/network/9606.ENSP00000321455Calcium uptake protein 3, mitochondrial; May play a role in mitochondrial calcium uptake.
KLHL38 protein networkhttps://string-db.org/network/9606.ENSP00000321475Kelch-like protein 38; Kelch like family member 38.
SLC37A3 protein networkhttps://string-db.org/network/9606.ENSP00000321498Sugar phosphate exchanger 3; Solute carrier family 37 member 3.
OR4X1 protein networkhttps://string-db.org/network/9606.ENSP00000321506Olfactory receptor 4X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
C19orf18 protein networkhttps://string-db.org/network/9606.ENSP00000321519Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18.
LLGL1 protein networkhttps://string-db.org/network/9606.ENSP00000321537Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic sp [...]
KBTBD11 protein networkhttps://string-db.org/network/9606.ENSP00000321544Kelch repeat and BTB domain containing 11.
BORCS5 protein networkhttps://string-db.org/network/9606.ENSP00000321546BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...]
DCBLD2 protein networkhttps://string-db.org/network/9606.ENSP00000321573Discoidin, CUB and LCCL domain containing 2.
IMPDH2 protein networkhttps://string-db.org/network/9606.ENSP00000321584Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthe [...]
CRMP1 protein networkhttps://string-db.org/network/9606.ENSP00000321606Dihydropyrimidinase-related protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance proces [...]
ANKZF1 protein networkhttps://string-db.org/network/9606.ENSP00000321617Ankyrin repeat and zinc finger domain-containing protein 1; Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellul [...]
ANKFN1 protein networkhttps://string-db.org/network/9606.ENSP00000321627Ankyrin repeat and fibronectin type III domain containing 1.
TOP3A protein networkhttps://string-db.org/network/9606.ENSP00000321636DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the D [...]
CDC25C protein networkhttps://string-db.org/network/9606.ENSP00000321656M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly eff [...]
ANKRD23 protein networkhttps://string-db.org/network/9606.ENSP00000321679Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression [...]
MEOX1 protein networkhttps://string-db.org/network/9606.ENSP00000321684Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome [...]
GATD1 protein networkhttps://string-db.org/network/9606.ENSP00000321691Glutamine amidotransferase like class 1 domain containing 1; Belongs to the peptidase C56 family.
TACC1 protein networkhttps://string-db.org/network/9606.ENSP00000321703Transforming acidic coiled-coil-containing protein 1; Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Migh [...]
GEMIN4 protein networkhttps://string-db.org/network/9606.ENSP00000321706Gem-associated protein 4; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...]
DIS3L protein networkhttps://string-db.org/network/9606.ENSP00000321711DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA proce [...]
OR51V1 protein networkhttps://string-db.org/network/9606.ENSP00000321729Olfactory receptor 51V1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SLC16A8 protein networkhttps://string-db.org/network/9606.ENSP00000321735Monocarboxylate transporter 3; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...]
H2BC4 protein networkhttps://string-db.org/network/9606.ENSP00000321744Histone H2B type 1-C/E/F/G/I; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template [...]
FGF8 protein networkhttps://string-db.org/network/9606.ENSP00000321797Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear an [...]
PAQR4 protein networkhttps://string-db.org/network/9606.ENSP00000321804Progestin and adipoQ receptor family member 4.
RIT2 protein networkhttps://string-db.org/network/9606.ENSP00000321805GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.
TRIT1 protein networkhttps://string-db.org/network/9606.ENSP00000321810tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethyla [...]
ZNF776 protein networkhttps://string-db.org/network/9606.ENSP00000321812Zinc finger protein 776; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
STXBP5 protein networkhttps://string-db.org/network/9606.ENSP00000321826Syntaxin-binding protein 5; Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May [...]
ETV4 protein networkhttps://string-db.org/network/9606.ENSP00000321835ETS translocation variant 4; Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.
ZNF671 protein networkhttps://string-db.org/network/9606.ENSP00000321848Zinc finger protein 671; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SERPINF2 protein networkhttps://string-db.org/network/9606.ENSP00000321853Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin.
CRELD1 protein networkhttps://string-db.org/network/9606.ENSP00000321856Protein disulfide isomerase CRELD1; Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane (By similarity); Belongs to th [...]
B3GNT3 protein networkhttps://string-db.org/network/9606.ENSP00000321874N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosacc [...]
FBXL13 protein networkhttps://string-db.org/network/9606.ENSP00000321927Dynein regulatory complex subunit 6; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dis [...]
FAIM2 protein networkhttps://string-db.org/network/9606.ENSP00000321951Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May pla [...]
FIBIN protein networkhttps://string-db.org/network/9606.ENSP00000321962Fin bud initiation factor homolog; Belongs to the FIBIN family.
ZSCAN4 protein networkhttps://string-db.org/network/9606.ENSP00000321963Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic [...]
RHOT2 protein networkhttps://string-db.org/network/9606.ENSP00000321971Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (B [...]
NKPD1 protein networkhttps://string-db.org/network/9606.ENSP00000321976NTPase KAP family P-loop domain containing 1.
TSPEAR protein networkhttps://string-db.org/network/9606.ENSP00000321987Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play [...]
LARP1B protein networkhttps://string-db.org/network/9606.ENSP00000321997La ribonucleoprotein 1B; Belongs to the LARP family.
SLC25A22 protein networkhttps://string-db.org/network/9606.ENSP00000322020Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). Belongs to the mitochondrial carrier (TC 2 [...]
C7 protein networkhttps://string-db.org/network/9606.ENSP00000322061Complement component C7; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. [...]
OR52E2 protein networkhttps://string-db.org/network/9606.ENSP00000322088Olfactory receptor 52E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ATG4C protein networkhttps://string-db.org/network/9606.ENSP00000322159Cysteine protease ATG4C; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required [...]
PFN4 protein networkhttps://string-db.org/network/9606.ENSP00000322170Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) [...]
DSCC1 protein networkhttps://string-db.org/network/9606.ENSP00000322180Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid coh [...]
DPM2 protein networkhttps://string-db.org/network/9606.ENSP00000322181Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; [...]
DEFB104B protein networkhttps://string-db.org/network/9606.ENSP00000322191Defensin beta 104B.
PGA3 protein networkhttps://string-db.org/network/9606.ENSP00000322192Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
PITPNM2 protein networkhttps://string-db.org/network/9606.ENSP00000322218Membrane-associated phosphatidylinositol transfer protein 2; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions.
FADS1 protein networkhttps://string-db.org/network/9606.ENSP00000322229Acyl-CoA (8-3)-desaturase; Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the ca [...]
C14orf119 protein networkhttps://string-db.org/network/9606.ENSP00000322238Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119.
ORAI3 protein networkhttps://string-db.org/network/9606.ENSP00000322249Protein orai-3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import; Belongs to the Orai family.
TNNI3K protein networkhttps://string-db.org/network/9606.ENSP00000322251Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
ZNF620 protein networkhttps://string-db.org/network/9606.ENSP00000322265Zinc finger protein 620; May be involved in transcriptional regulation.
OLFML3 protein networkhttps://string-db.org/network/9606.ENSP00000322273Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) a [...]
VNN2 protein networkhttps://string-db.org/network/9606.ENSP00000322276Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cystea [...]
TMTC2 protein networkhttps://string-db.org/network/9606.ENSP00000322300Protein O-mannosyl-transferase TMTC2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated pr [...]
PORCN protein networkhttps://string-db.org/network/9606.ENSP00000322304Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, [...]
COQ7 protein networkhttps://string-db.org/network/9606.ENSP000003223165-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural rol [...]
FAM20C protein networkhttps://string-db.org/network/9606.ENSP00000322323Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in bio [...]
VN1R1 protein networkhttps://string-db.org/network/9606.ENSP00000322339Vomeronasal type-1 receptor 1; Putative pheromone receptor; Belongs to the G-protein coupled receptor 1 family.
CDK20 protein networkhttps://string-db.org/network/9606.ENSP00000322343Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of th [...]
ZNF236 protein networkhttps://string-db.org/network/9606.ENSP00000322361Zinc finger protein 236; May be involved in transcriptional regulation.
PLEKHF2 protein networkhttps://string-db.org/network/9606.ENSP00000322373Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellu [...]
RRS1 protein networkhttps://string-db.org/network/9606.ENSP00000322396Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs t [...]
KDM5D protein networkhttps://string-db.org/network/9606.ENSP00000322408Lysine-specific demethylase 5D; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', [...]
HBA1 protein networkhttps://string-db.org/network/9606.ENSP00000322421Hemoglobin subunit alpha 1.
TUFM protein networkhttps://string-db.org/network/9606.ENSP00000322439Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy [...]
SIAH2 protein networkhttps://string-db.org/network/9606.ENSP00000322457E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from a [...]
SCN4B protein networkhttps://string-db.org/network/9606.ENSP00000322460Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage [...]
C3orf38 protein networkhttps://string-db.org/network/9606.ENSP00000322469Uncharacterized protein C3orf38; May be involved in apoptosis regulation.
DCTPP1 protein networkhttps://string-db.org/network/9606.ENSP00000322524dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and [...]
PELI3 protein networkhttps://string-db.org/network/9606.ENSP00000322532E3 ubiquitin-protein ligase pellino homolog 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathwa [...]
ZNF543 protein networkhttps://string-db.org/network/9606.ENSP00000322545Zinc finger protein 543; May be involved in transcriptional regulation.
SOX11 protein networkhttps://string-db.org/network/9606.ENSP00000322568Transcription factor SOX-11; Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.
POLE protein networkhttps://string-db.org/network/9606.ENSP00000322570DNA polymerase epsilon catalytic subunit A; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication (By similarity). Required during synthesis of th [...]
PHF23 protein networkhttps://string-db.org/network/9606.ENSP00000322579PHD finger protein 23; Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvat [...]
C4orf17 protein networkhttps://string-db.org/network/9606.ENSP00000322582Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17.
RAB39A protein networkhttps://string-db.org/network/9606.ENSP00000322594Ras-related protein Rab-39A; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Play [...]
ERICH3 protein networkhttps://string-db.org/network/9606.ENSP00000322609Glutamate-rich protein 3; Glutamate rich 3.
HTR3C protein networkhttps://string-db.org/network/9606.ENSP000003226175-hydroxytryptamine receptor 3C; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
ARL4D protein networkhttps://string-db.org/network/9606.ENSP00000322628ADP-ribosylation factor-like protein 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...]
SPATA31E1 protein networkhttps://string-db.org/network/9606.ENSP00000322640Spermatogenesis-associated protein 31E1; May play a role in spermatogenesis; Belongs to the SPATA31 family.
SLC25A41 protein networkhttps://string-db.org/network/9606.ENSP00000322649Solute carrier family 25 member 41.
HMGCS1 protein networkhttps://string-db.org/network/9606.ENSP00000322706Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
GLYR1 protein networkhttps://string-db.org/network/9606.ENSP00000322716Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes. Binds DNA (in vi [...]
ITM2C protein networkhttps://string-db.org/network/9606.ENSP00000322730Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-sec [...]
OR51S1 protein networkhttps://string-db.org/network/9606.ENSP00000322754Olfactory receptor 51S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RHBDF2 protein networkhttps://string-db.org/network/9606.ENSP00000322775Inactive rhomboid protein 2; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migr [...]
OR5AK2 protein networkhttps://string-db.org/network/9606.ENSP00000322784Olfactory receptor 5AK2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MMP1 protein networkhttps://string-db.org/network/9606.ENSP0000032278822 kDa interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cl [...]
OR52N2 protein networkhttps://string-db.org/network/9606.ENSP00000322801Olfactory receptor 52N2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TSPYL5 protein networkhttps://string-db.org/network/9606.ENSP00000322802Testis-specific Y-encoded-like protein 5; Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulati [...]
MTSS1 protein networkhttps://string-db.org/network/9606.ENSP00000322804Protein MTSS 1; May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.
ROGDI protein networkhttps://string-db.org/network/9606.ENSP00000322832Protein rogdi homolog; Rogdi atypical leucine zipper.
TMEM40 protein networkhttps://string-db.org/network/9606.ENSP00000322837Transmembrane protein 40.
ZMYM3 protein networkhttps://string-db.org/network/9606.ENSP00000322845Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization.
DTX2 protein networkhttps://string-db.org/network/9606.ENSP00000322885Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Prob [...]
EBF1 protein networkhttps://string-db.org/network/9606.ENSP00000322898Transcription factor COE1; Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
ZNF843 protein networkhttps://string-db.org/network/9606.ENSP00000322899Zinc finger protein 843.
ZMYM4 protein networkhttps://string-db.org/network/9606.ENSP00000322915Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization.
HTR1F protein networkhttps://string-db.org/network/9606.ENSP000003229245-hydroxytryptamine receptor 1F; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding cau [...]
LRSAM1 protein networkhttps://string-db.org/network/9606.ENSP00000322937E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF re [...]
OR56B1 protein networkhttps://string-db.org/network/9606.ENSP00000322939Olfactory receptor 56B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MFAP3 protein networkhttps://string-db.org/network/9606.ENSP00000322956Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils.
BCAT2 protein networkhttps://string-db.org/network/9606.ENSP00000322991Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also fun [...]
ACPP protein networkhttps://string-db.org/network/9606.ENSP00000323036Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphat [...]
EXOSC3 protein networkhttps://string-db.org/network/9606.ENSP00000323046Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
MTG1 protein networkhttps://string-db.org/network/9606.ENSP00000323047Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to [...]
EIF2S3B protein networkhttps://string-db.org/network/9606.ENSP00000323063Eukaryotic translation initiation factor 2 subunit gamma B.
GADD45GIP1 protein networkhttps://string-db.org/network/9606.ENSP00000323065Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effe [...]
TMEM168 protein networkhttps://string-db.org/network/9606.ENSP00000323068Transmembrane protein 168; Belongs to the TMEM168 family.
ACOT4 protein networkhttps://string-db.org/network/9606.ENSP00000323071Peroxisomal succinyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...]
RAI1 protein networkhttps://string-db.org/network/9606.ENSP00000323074Retinoic acid-induced protein 1; Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transc [...]
NDUFAF3 protein networkhttps://string-db.org/network/9606.ENSP00000323076NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
AMIGO3 protein networkhttps://string-db.org/network/9606.ENSP00000323096Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity).
ATRIP protein networkhttps://string-db.org/network/9606.ENSP00000323099ATR-interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Belongs to the ATRIP family.
ZKSCAN1 protein networkhttps://string-db.org/network/9606.ENSP00000323148Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation.
DAND5 protein networkhttps://string-db.org/network/9606.ENSP00000323155DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot- containing proteins play important rol [...]
ZBTB2 protein networkhttps://string-db.org/network/9606.ENSP00000323183Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation.
SAGE1 protein networkhttps://string-db.org/network/9606.ENSP00000323191Sarcoma antigen 1.
GOLGA8R protein networkhttps://string-db.org/network/9606.ENSP00000323217Golgin A8 family member R.
E2F7 protein networkhttps://string-db.org/network/9606.ENSP00000323246Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly act [...]
MARVELD2 protein networkhttps://string-db.org/network/9606.ENSP00000323264MARVEL domain-containing protein 2; Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separa [...]
DNAAF4 protein networkhttps://string-db.org/network/9606.ENSP00000323275Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the st [...]
CD6 protein networkhttps://string-db.org/network/9606.ENSP00000323280T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades [...]
RPUSD2 protein networkhttps://string-db.org/network/9606.ENSP00000323288RNA pseudouridine synthase domain containing 2.
SPAG5 protein networkhttps://string-db.org/network/9606.ENSP00000323300Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing o [...]
POC1B protein networkhttps://string-db.org/network/9606.ENSP00000323302POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps [...]
LSMEM1 protein networkhttps://string-db.org/network/9606.ENSP00000323304Leucine rich single-pass membrane protein 1.
PDIA5 protein networkhttps://string-db.org/network/9606.ENSP00000323313Protein disulfide-isomerase A5; Protein disulfide isomerase family A member 5.
SIGLEC7 protein networkhttps://string-db.org/network/9606.ENSP00000323328Sialic acid-binding Ig-like lectin 7; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also bi [...]
CBLL2 protein networkhttps://string-db.org/network/9606.ENSP00000323348E3 ubiquitin-protein ligase CBLL2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates.
OR5M8 protein networkhttps://string-db.org/network/9606.ENSP00000323354Olfactory receptor 5M8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FAM187B protein networkhttps://string-db.org/network/9606.ENSP00000323355Protein FAM187B; Family with sequence similarity 187 member B.
SMC1A protein networkhttps://string-db.org/network/9606.ENSP00000323421Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for th [...]
ISG20L2 protein networkhttps://string-db.org/network/9606.ENSP00000323424Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containi [...]
SNX22 protein networkhttps://string-db.org/network/9606.ENSP00000323435Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the [...]
TPRX1 protein networkhttps://string-db.org/network/9606.ENSP00000323455Tetrapeptide repeat homeobox 1.
PNKP protein networkhttps://string-db.org/network/9606.ENSP00000323511Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) path [...]
UTS2R protein networkhttps://string-db.org/network/9606.ENSP00000323516Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messeng [...]
MKLN1 protein networkhttps://string-db.org/network/9606.ENSP00000323527Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcr [...]
SLC6A18 protein networkhttps://string-db.org/network/9606.ENSP00000323549Inactive sodium-dependent neutral amino acid transporter B(0)AT3; Does not show neutral amino acid transporter activity.
SLC2A2 protein networkhttps://string-db.org/network/9606.ENSP00000323568Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer [...]
IFT88 protein networkhttps://string-db.org/network/9606.ENSP00000323580Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic c [...]
ITLN1 protein networkhttps://string-db.org/network/9606.ENSP00000323587Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, includin [...]
SOX2 protein networkhttps://string-db.org/network/9606.ENSP00000323588Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FG [...]
FAM210A protein networkhttps://string-db.org/network/9606.ENSP00000323635Protein FAM210A; May play a role in the structure and strength of both muscle and bone.
TTC39C protein networkhttps://string-db.org/network/9606.ENSP00000323645Tetratricopeptide repeat domain 39C.
DBF4B protein networkhttps://string-db.org/network/9606.ENSP00000323663Protein DBF4 homolog B; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and [...]
ZBTB7A protein networkhttps://string-db.org/network/9606.ENSP00000323670Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and s [...]
ZADH2 protein networkhttps://string-db.org/network/9606.ENSP00000323678Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto [...]
UBE2O protein networkhttps://string-db.org/network/9606.ENSP00000323687(E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negative [...]
OR5T2 protein networkhttps://string-db.org/network/9606.ENSP00000323688Olfactory receptor 5T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CRTAP protein networkhttps://string-db.org/network/9606.ENSP00000323696Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family.
MED14 protein networkhttps://string-db.org/network/9606.ENSP00000323720Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
UCP3 protein networkhttps://string-db.org/network/9606.ENSP00000323740Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a re [...]
CCDC43 protein networkhttps://string-db.org/network/9606.ENSP00000323782Coiled-coil domain containing 43; Belongs to the CCDC43 family.
TEX35 protein networkhttps://string-db.org/network/9606.ENSP00000323795Testis-expressed protein 35; Testis expressed 35.
HACL1 protein networkhttps://string-db.org/network/9606.ENSP000003238112-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme fam [...]
AHRR protein networkhttps://string-db.org/network/9606.ENSP00000323816Aryl hydrocarbon receptor repressor; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this [...]
ARL14 protein networkhttps://string-db.org/network/9606.ENSP00000323847ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along th [...]
OR8K5 protein networkhttps://string-db.org/network/9606.ENSP00000323853Olfactory receptor 8K5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PLEC protein networkhttps://string-db.org/network/9606.ENSP00000323856Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin t [...]
DDX54 protein networkhttps://string-db.org/network/9606.ENSP00000323858ATP-dependent RNA helicase DDX54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors.
PRKAG1 protein networkhttps://string-db.org/network/9606.ENSP000003238675'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...]
P2RY11 protein networkhttps://string-db.org/network/9606.ENSP00000323872P2Y purinoceptor 11; Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
ZNRF2 protein networkhttps://string-db.org/network/9606.ENSP00000323879E3 ubiquitin-protein ligase ZNRF2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiq [...]
FOXJ1 protein networkhttps://string-db.org/network/9606.ENSP00000323880Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFA [...]
TRIM25 protein networkhttps://string-db.org/network/9606.ENSP00000323889E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. M [...]
FZD2 protein networkhttps://string-db.org/network/9606.ENSP00000323901Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...]
TRIM55 protein networkhttps://string-db.org/network/9606.ENSP00000323913Tripartite motif-containing protein 55; May regulate gene expression and protein turnover in muscle cells.
TRPM8 protein networkhttps://string-db.org/network/9606.ENSP00000323926Transient receptor potential cation channel subfamily M member 8; Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold [...]
PLXDC1 protein networkhttps://string-db.org/network/9606.ENSP00000323927Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis.
OR8H3 protein networkhttps://string-db.org/network/9606.ENSP00000323928Olfactory receptor 8H3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
A2M protein networkhttps://string-db.org/network/9606.ENSP00000323929Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cl [...]
ZNF771 protein networkhttps://string-db.org/network/9606.ENSP00000323945Zinc finger protein 771; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SMARCE1 protein networkhttps://string-db.org/network/9606.ENSP00000323967SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...]
CRIPAK protein networkhttps://string-db.org/network/9606.ENSP00000323978Cysteine-rich PAK1 inhibitor; Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence.
KIF15 protein networkhttps://string-db.org/network/9606.ENSP00000324020Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 s [...]
ZNF48 protein networkhttps://string-db.org/network/9606.ENSP00000324056Zinc finger protein 48; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF354C protein networkhttps://string-db.org/network/9606.ENSP00000324064Zinc finger protein 354C; May function as a transcription repressor. Binds to 5'-CCACA- 3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation ( [...]
CD151 protein networkhttps://string-db.org/network/9606.ENSP00000324101CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
ENO3 protein networkhttps://string-db.org/network/9606.ENSP00000324105Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family.
PRPF31 protein networkhttps://string-db.org/network/9606.ENSP00000324122U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks [...]
POLR2L protein networkhttps://string-db.org/network/9606.ENSP00000324124DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...]
PSD3 protein networkhttps://string-db.org/network/9606.ENSP00000324127PH and SEC7 domain-containing protein 3; Guanine nucleotide exchange factor for ARF6.
HSPA5 protein networkhttps://string-db.org/network/9606.ENSP00000324173Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct foldi [...]
MAMSTR protein networkhttps://string-db.org/network/9606.ENSP00000324175MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF [...]
KCNRG protein networkhttps://string-db.org/network/9606.ENSP00000324191Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes.
AATK protein networkhttps://string-db.org/network/9606.ENSP00000324196Serine/threonine-protein kinase LMTK1; May be involved in neuronal differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family.
WRAP53 protein networkhttps://string-db.org/network/9606.ENSP00000324203Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) p [...]
MTURN protein networkhttps://string-db.org/network/9606.ENSP00000324204Maturin; Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression. Represses NF-kappa-B transcriptional activity by inhibiting [...]
OXTR protein networkhttps://string-db.org/network/9606.ENSP00000324270Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein c [...]
APOLD1 protein networkhttps://string-db.org/network/9606.ENSP00000324277Apolipoprotein L domain-containing protein 1; May be involved in angiogenesis. May play a role in activity- dependent changes of brain vasculature. May affect blood-brain permeability.
ACAP2 protein networkhttps://string-db.org/network/9606.ENSP00000324287Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
STXBP6 protein networkhttps://string-db.org/network/9606.ENSP00000324302Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
TRAPPC12 protein networkhttps://string-db.org/network/9606.ENSP00000324318Trafficking protein particle complex subunit 12; Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role [...]
TCTEX1D2 protein networkhttps://string-db.org/network/9606.ENSP00000324323Tctex1 domain-containing protein 2; Required for proper retrograde ciliary transport. Belongs to the dynein light chain Tctex-type family.
UPB1 protein networkhttps://string-db.org/network/9606.ENSP00000324343Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N- [...]
PHF21B protein networkhttps://string-db.org/network/9606.ENSP00000324403PHD finger protein 21B.
TCHP protein networkhttps://string-db.org/network/9606.ENSP00000324404Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate c [...]
SYT9 protein networkhttps://string-db.org/network/9606.ENSP00000324419Synaptotagmin-9; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...]
ZYX protein networkhttps://string-db.org/network/9606.ENSP00000324422Zyxin; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. [...]
YLPM1 protein networkhttps://string-db.org/network/9606.ENSP00000324463YLP motif-containing protein 1; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its dow [...]
BAIAP3 protein networkhttps://string-db.org/network/9606.ENSP00000324510BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endos [...]
SEPTIN1 protein networkhttps://string-db.org/network/9606.ENSP00000324511Septin-1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin G [...]
MYO1D protein networkhttps://string-db.org/network/9606.ENSP00000324527Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in [...]
LAMA3 protein networkhttps://string-db.org/network/9606.ENSP00000324532Laminin subunit alpha-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
OR14C36 protein networkhttps://string-db.org/network/9606.ENSP00000324534Olfactory receptor 14C36; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2M7 protein networkhttps://string-db.org/network/9606.ENSP00000324557Olfactory receptor 2M7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ULK1 protein networkhttps://string-db.org/network/9606.ENSP00000324560Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the format [...]
FLII protein networkhttps://string-db.org/network/9606.ENSP00000324573Protein flightless-1 homolog; May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in es [...]
FAM193A protein networkhttps://string-db.org/network/9606.ENSP00000324587Protein FAM193A; Family with sequence similarity 193 member A; Belongs to the FAM193 family.
ZNF540 protein networkhttps://string-db.org/network/9606.ENSP00000324598Zinc finger protein 540; May act as a transcriptional repressor.
ZNF660 protein networkhttps://string-db.org/network/9606.ENSP00000324605Zinc finger protein 660; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NAPG protein networkhttps://string-db.org/network/9606.ENSP00000324628Gamma-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family.
DEFB103B protein networkhttps://string-db.org/network/9606.ENSP00000324633Defensin beta 103B.
CYP2B6 protein networkhttps://string-db.org/network/9606.ENSP00000324648Cytochrome P450 2B6; A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate [...]
TMEM108 protein networkhttps://string-db.org/network/9606.ENSP00000324651Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surfa [...]
C16orf89 protein networkhttps://string-db.org/network/9606.ENSP00000324672UPF0764 protein C16orf89; Chromosome 16 open reading frame 89; Belongs to the UPF0764 family.
GRHL1 protein networkhttps://string-db.org/network/9606.ENSP00000324693Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context [...]
MAB21L2 protein networkhttps://string-db.org/network/9606.ENSP00000324701Protein mab-21-like 2; Required for several aspects of embryonic development including normal development of the eye; Belongs to the mab-21 family.
SAV1 protein networkhttps://string-db.org/network/9606.ENSP00000324729Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...]
MAP11 protein networkhttps://string-db.org/network/9606.ENSP00000324741Microtubule-associated protein 11; Microtubule associated protein wich seems to play a role in spindle dynamics and cell division. Modulates YAP1 activity as transcriptional regulator.
WFIKKN1 protein networkhttps://string-db.org/network/9606.ENSP00000324763WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metallopro [...]
NFATC2IP protein networkhttps://string-db.org/network/9606.ENSP00000324792NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. [...]
PPP2R1A protein networkhttps://string-db.org/network/9606.ENSP00000324804Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the ca [...]
GSK3B protein networkhttps://string-db.org/network/9606.ENSP00000324806Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcripti [...]
MVB12A protein networkhttps://string-db.org/network/9606.ENSP00000324810Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bod [...]
AKAP17A protein networkhttps://string-db.org/network/9606.ENSP00000324827A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner.
AACS protein networkhttps://string-db.org/network/9606.ENSP00000324842Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity); Bel [...]
STK11 protein networkhttps://string-db.org/network/9606.ENSP00000324856Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in [...]
SEMA6D protein networkhttps://string-db.org/network/9606.ENSP00000324857Semaphorin-6D; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other ne [...]
CD28 protein networkhttps://string-db.org/network/9606.ENSP00000324890T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of [...]
IQCK protein networkhttps://string-db.org/network/9606.ENSP00000324901IQ motif containing K.
C14orf39 protein networkhttps://string-db.org/network/9606.ENSP00000324920Protein SIX6OS1; Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropria [...]
MBOAT1 protein networkhttps://string-db.org/network/9606.ENSP00000324944Lysophospholipid acyltransferase 1; Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-di [...]
RNF14 protein networkhttps://string-db.org/network/9606.ENSP00000324956E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which co [...]
OR4C15 protein networkhttps://string-db.org/network/9606.ENSP00000324958Olfactory receptor 4C15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CABP4 protein networkhttps://string-db.org/network/9606.ENSP00000324960Calcium-binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. [...]
COPG1 protein networkhttps://string-db.org/network/9606.ENSP00000325002Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosy [...]
NCAPD2 protein networkhttps://string-db.org/network/9606.ENSP00000325017Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...]
ZNF569 protein networkhttps://string-db.org/network/9606.ENSP00000325018Zinc finger protein 569; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
OR4A15 protein networkhttps://string-db.org/network/9606.ENSP00000325065Olfactory receptor 4A15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PPP2R2A protein networkhttps://string-db.org/network/9606.ENSP00000325074Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...]
OR2AJ1 protein networkhttps://string-db.org/network/9606.ENSP00000325078Olfactory receptor 2AJ1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LRCH2 protein networkhttps://string-db.org/network/9606.ENSP00000325091Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton.
PGR protein networkhttps://string-db.org/network/9606.ENSP00000325120Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissue [...]
OR4A16 protein networkhttps://string-db.org/network/9606.ENSP00000325128Olfactory receptor 4A16; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
HADHB protein networkhttps://string-db.org/network/9606.ENSP00000325136Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial [...]
COL12A1 protein networkhttps://string-db.org/network/9606.ENSP00000325146Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains [...]
OR6T1 protein networkhttps://string-db.org/network/9606.ENSP00000325203Olfactory receptor 6T1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MYLPF protein networkhttps://string-db.org/network/9606.ENSP00000325239Myosin light chain, phosphorylatable, fast skeletal muscle.
LASP1 protein networkhttps://string-db.org/network/9606.ENSP00000325240LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regu [...]
TTC9C protein networkhttps://string-db.org/network/9606.ENSP00000325266Tetratricopeptide repeat domain 9C; Belongs to the TTC9 family.
MTMR4 protein networkhttps://string-db.org/network/9606.ENSP00000325285Myotubularin-related protein 4; Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para- nitrophenylphosphate. Phosphorylates ph [...]
HASPIN protein networkhttps://string-db.org/network/9606.ENSP00000325290Serine/threonine-protein kinase haspin; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate act [...]
PKD2L1 protein networkhttps://string-db.org/network/9606.ENSP00000325296Polycystic kidney disease 2-like 1 protein; Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium- permeant ion c [...]
CDPF1 protein networkhttps://string-db.org/network/9606.ENSP00000325301Cysteine rich DPF motif domain containing 1.
METAP2 protein networkhttps://string-db.org/network/9606.ENSP00000325312Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence [...]
MAP1S protein networkhttps://string-db.org/network/9606.ENSP00000325313Microtubule-associated protein 1S; Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the m [...]
ZNF335 protein networkhttps://string-db.org/network/9606.ENSP00000325326Zinc finger protein 335; Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhance [...]
CASKIN2 protein networkhttps://string-db.org/network/9606.ENSP00000325355Caskin-2; CASK interacting protein 2.
AP3S1 protein networkhttps://string-db.org/network/9606.ENSP00000325369AP-3 complex subunit sigma-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...]
HNRNPM protein networkhttps://string-db.org/network/9606.ENSP00000325376Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoemb [...]
WDR33 protein networkhttps://string-db.org/network/9606.ENSP00000325377pre-mRNA 3' end processing protein WDR33; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
TPRKB protein networkhttps://string-db.org/network/9606.ENSP00000325398EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...]
MYPOP protein networkhttps://string-db.org/network/9606.ENSP00000325402Myb-related transcription factor, partner of profilin; Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduce [...]
PARL protein networkhttps://string-db.org/network/9606.ENSP00000325421Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 w [...]
MAT2B protein networkhttps://string-db.org/network/9606.ENSP00000325425Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Reg [...]
KARS1 protein networkhttps://string-db.org/network/9606.ENSP00000325448Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred [...]
CERS5 protein networkhttps://string-db.org/network/9606.ENSP00000325485Ceramide synthase 5; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as a [...]
C11orf71 protein networkhttps://string-db.org/network/9606.ENSP00000325508Uncharacterized protein C11orf71; Chromosome 11 open reading frame 71.
KIR3DL2 protein networkhttps://string-db.org/network/9606.ENSP00000325525Killer cell immunoglobulin-like receptor 3DL2; Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates [...]
WNT11 protein networkhttps://string-db.org/network/9606.ENSP00000325526Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...]
FBN1 protein networkhttps://string-db.org/network/9606.ENSP00000325527Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connect [...]
PLAG1 protein networkhttps://string-db.org/network/9606.ENSP00000325546Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultur [...]
CNDP2 protein networkhttps://string-db.org/network/9606.ENSP00000325548Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via a [...]
TMC8 protein networkhttps://string-db.org/network/9606.ENSP00000325561Transmembrane channel-like protein 8; Probable ion channel; Belongs to the TMC family.
MICOS10 protein networkhttps://string-db.org/network/9606.ENSP00000325562MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
SYCN protein networkhttps://string-db.org/network/9606.ENSP00000325564Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in o [...]
PTPRCAP protein networkhttps://string-db.org/network/9606.ENSP00000325589Protein tyrosine phosphatase receptor type C associated protein.
RUFY1 protein networkhttps://string-db.org/network/9606.ENSP00000325594RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.
MED16 protein networkhttps://string-db.org/network/9606.ENSP00000325612Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
ZNF639 protein networkhttps://string-db.org/network/9606.ENSP00000325634Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family.
PRM3 protein networkhttps://string-db.org/network/9606.ENSP00000325638Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex [...]
CHCHD5 protein networkhttps://string-db.org/network/9606.ENSP00000325655Coiled-coil-helix-coiled-coil-helix domain containing 5.
NFKBIZ protein networkhttps://string-db.org/network/9606.ENSP00000325663NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits [...]
EXOC3L1 protein networkhttps://string-db.org/network/9606.ENSP00000325674Exocyst complex component 3-like protein; As part of the exocyst, may play a role in regulated exocytosis of insulin granules.
RNF40 protein networkhttps://string-db.org/network/9606.ENSP00000325677E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a spec [...]
CCZ1 protein networkhttps://string-db.org/network/9606.ENSP00000325681CCZ1 homolog, vacuolar protein trafficking and biogenesis associated.
CARM1 protein networkhttps://string-db.org/network/9606.ENSP00000325690Histone-arginine methyltransferase CARM1; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription [...]
CD37 protein networkhttps://string-db.org/network/9606.ENSP00000325708Leukocyte antigen CD37; CD37 molecule.
TNP2 protein networkhttps://string-db.org/network/9606.ENSP00000325738Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it [...]
STK25 protein networkhttps://string-db.org/network/9606.ENSP00000325748Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears [...]
GJC3 protein networkhttps://string-db.org/network/9606.ENSP00000325775Gap junction gamma-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
SERTM1 protein networkhttps://string-db.org/network/9606.ENSP00000325776Serine rich and transmembrane domain containing 1.
SPECC1L protein networkhttps://string-db.org/network/9606.ENSP00000325785Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migr [...]
LRRN4CL protein networkhttps://string-db.org/network/9606.ENSP00000325808LRRN4 C-terminal-like protein; LRRN4 C-terminal like.
NR2F1 protein networkhttps://string-db.org/network/9606.ENSP00000325819COUP transcription factor 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiati [...]
CYP11B2 protein networkhttps://string-db.org/network/9606.ENSP00000325822Cytochrome P450 11B2, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11 [...]
SEC16A protein networkhttps://string-db.org/network/9606.ENSP00000325827Protein transport protein Sec16A; Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic ret [...]
DIRAS1 protein networkhttps://string-db.org/network/9606.ENSP00000325836GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form.
MRE11 protein networkhttps://string-db.org/network/9606.ENSP00000325863Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and me [...]
ODF3 protein networkhttps://string-db.org/network/9606.ENSP00000325868Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maint [...]
ANKDD1A protein networkhttps://string-db.org/network/9606.ENSP00000325895Ankyrin repeat and death domain containing 1A.
SRSF7 protein networkhttps://string-db.org/network/9606.ENSP00000325905Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter [...]
PCSK7 protein networkhttps://string-db.org/network/9606.ENSP00000325917Proprotein convertase subtilisin/kexin type 7; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...]
PSMG2 protein networkhttps://string-db.org/network/9606.ENSP00000325919Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 prot [...]
LNX2 protein networkhttps://string-db.org/network/9606.ENSP00000325929Ligand of numb-protein X 2.
RIC8A protein networkhttps://string-db.org/network/9606.ENSP00000325941Synembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for fre [...]
CDHR3 protein networkhttps://string-db.org/network/9606.ENSP00000325954Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may th [...]
PTPMT1 protein networkhttps://string-db.org/network/9606.ENSP00000325958Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (By similarity). PGP is [...]
LRRC31 protein networkhttps://string-db.org/network/9606.ENSP00000325978Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31.
PUS10 protein networkhttps://string-db.org/network/9606.ENSP00000326003Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formatio [...]
PRX protein networkhttps://string-db.org/network/9606.ENSP00000326018Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the mainte [...]
FHL5 protein networkhttps://string-db.org/network/9606.ENSP00000326022Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner.
PPP1CA protein networkhttps://string-db.org/network/9606.ENSP00000326031Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate h [...]
TUBA3D protein networkhttps://string-db.org/network/9606.ENSP00000326042Detyrosinated tubulin alpha-3C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site [...]
COX14 protein networkhttps://string-db.org/network/9606.ENSP00000326052Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cyto [...]
TMEM39A protein networkhttps://string-db.org/network/9606.ENSP00000326063Transmembrane protein 39A; Belongs to the TMEM39 family.
SLC41A3 protein networkhttps://string-db.org/network/9606.ENSP00000326070Solute carrier family 41 member 3.
RNF166 protein networkhttps://string-db.org/network/9606.ENSP00000326095E3 ubiquitin-protein ligase RNF166; E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interfe [...]
C5orf30 protein networkhttps://string-db.org/network/9606.ENSP00000326110Macrophage immunometabolism regulator; Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macr [...]
PMAIP1 protein networkhttps://string-db.org/network/9606.ENSP00000326119Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. [...]
LARP4B protein networkhttps://string-db.org/network/9606.ENSP00000326128La-related protein 4B; Stimulates mRNA translation.
KLK4 protein networkhttps://string-db.org/network/9606.ENSP00000326159Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline [...]
RFFL protein networkhttps://string-db.org/network/9606.ENSP00000326170E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. M [...]
ZBTB11 protein networkhttps://string-db.org/network/9606.ENSP00000326200Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation.
DHRS4 protein networkhttps://string-db.org/network/9606.ENSP00000326219Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficien [...]
GANC protein networkhttps://string-db.org/network/9606.ENSP00000326227Neutral alpha-glucosidase C; Has alpha-glucosidase activity. Belongs to the glycosyl hydrolase 31 family.
OR52D1 protein networkhttps://string-db.org/network/9606.ENSP00000326232Olfactory receptor 52D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CAPZA3 protein networkhttps://string-db.org/network/9606.ENSP00000326238F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...]
MYNN protein networkhttps://string-db.org/network/9606.ENSP00000326240Myoneurin.
TMEM151A protein networkhttps://string-db.org/network/9606.ENSP00000326244Transmembrane protein 151A.
SAMD9L protein networkhttps://string-db.org/network/9606.ENSP00000326247Sterile alpha motif domain-containing protein 9-like; May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors.
ZNF454 protein networkhttps://string-db.org/network/9606.ENSP00000326249Zinc finger protein 454; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RTBDN protein networkhttps://string-db.org/network/9606.ENSP00000326253Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport.
SRRM1 protein networkhttps://string-db.org/network/9606.ENSP00000326261Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing [...]
EFCAB11 protein networkhttps://string-db.org/network/9606.ENSP00000326267EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11.
FOXL1 protein networkhttps://string-db.org/network/9606.ENSP00000326272Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 [...]
OR2G3 protein networkhttps://string-db.org/network/9606.ENSP00000326301Olfactory receptor 2G3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SLC25A20 protein networkhttps://string-db.org/network/9606.ENSP00000326305Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial m [...]
DEFB124 protein networkhttps://string-db.org/network/9606.ENSP00000326309Beta-defensin 124; Has antibacterial activity; Belongs to the beta-defensin family.
LRRC37A protein networkhttps://string-db.org/network/9606.ENSP00000326324Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A.
ATG16L2 protein networkhttps://string-db.org/network/9606.ENSP00000326340Autophagy-related protein 16-2; May play a role in autophagy.
ELMOD2 protein networkhttps://string-db.org/network/9606.ENSP00000326342ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. [...]
OR2G2 protein networkhttps://string-db.org/network/9606.ENSP00000326349Olfactory receptor 2G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PSEN1 protein networkhttps://string-db.org/network/9606.ENSP00000326366Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors [...]
EIF4A2 protein networkhttps://string-db.org/network/9606.ENSP00000326381Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current mod [...]
CLEC1A protein networkhttps://string-db.org/network/9606.ENSP00000326407C-type lectin domain family 1 member A.
CWF19L1 protein networkhttps://string-db.org/network/9606.ENSP00000326411CWF19-like protein 1; CWF19 like cell cycle control factor 1.
NADSYN1 protein networkhttps://string-db.org/network/9606.ENSP00000326424Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
CCR8 protein networkhttps://string-db.org/network/9606.ENSP00000326432C-C chemokine receptor type 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
SHISA3 protein networkhttps://string-db.org/network/9606.ENSP00000326445Protein shisa-3 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
ABHD1 protein networkhttps://string-db.org/network/9606.ENSP00000326491Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
PAGR1 protein networkhttps://string-db.org/network/9606.ENSP00000326519PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in associa [...]
THOC6 protein networkhttps://string-db.org/network/9606.ENSP00000326531THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically ass [...]
TACC3 protein networkhttps://string-db.org/network/9606.ENSP00000326550Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-medi [...]
KDM3B protein networkhttps://string-db.org/network/9606.ENSP00000326563Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates fo [...]
FKRP protein networkhttps://string-db.org/network/9606.ENSP00000326570Fukutin-related protein; Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- [...]
PEG3 protein networkhttps://string-db.org/network/9606.ENSP00000326581Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts sy [...]
PRSS50 protein networkhttps://string-db.org/network/9606.ENSP00000326598Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family.
SMCHD1 protein networkhttps://string-db.org/network/9606.ENSP00000326603Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in e [...]
LMBR1 protein networkhttps://string-db.org/network/9606.ENSP00000326604Limb region 1 protein homolog; Putative membrane receptor.
ZFPM1 protein networkhttps://string-db.org/network/9606.ENSP00000326630Zinc finger protein ZFPM1; Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodim [...]
HPS1 protein networkhttps://string-db.org/network/9606.ENSP00000326649Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting t [...]
FAM71F1 protein networkhttps://string-db.org/network/9606.ENSP00000326652Protein FAM71F1; Family with sequence similarity 71 member F1.
SLC47A2 protein networkhttps://string-db.org/network/9606.ENSP00000326671Multidrug and toxin extrusion protein 2; Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, p [...]
SLC25A42 protein networkhttps://string-db.org/network/9606.ENSP00000326693Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and [...]
PLEKHO2 protein networkhttps://string-db.org/network/9606.ENSP00000326706Pleckstrin homology domain containing O2.
OVCH1 protein networkhttps://string-db.org/network/9606.ENSP00000326708Ovochymase-1; Ovochymase 1.
OR10A7 protein networkhttps://string-db.org/network/9606.ENSP00000326718Olfactory receptor 10A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TNFRSF12A protein networkhttps://string-db.org/network/9606.ENSP00000326737Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. [...]
LRIG3 protein networkhttps://string-db.org/network/9606.ENSP00000326759Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epitheliu [...]
MED25 protein networkhttps://string-db.org/network/9606.ENSP00000326767Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
CUL1 protein networkhttps://string-db.org/network/9606.ENSP00000326804Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle pr [...]
NCBP2 protein networkhttps://string-db.org/network/9606.ENSP00000326806Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mR [...]
YOD1 protein networkhttps://string-db.org/network/9606.ENSP00000326813Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. M [...]
LRRC57 protein networkhttps://string-db.org/network/9606.ENSP00000326817Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57.
C14orf28 protein networkhttps://string-db.org/network/9606.ENSP00000326846Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28.
NT5DC1 protein networkhttps://string-db.org/network/9606.ENSP000003268585'-nucleotidase domain containing 1.
ORMDL1 protein networkhttps://string-db.org/network/9606.ENSP00000326869ORM1-like protein 1; Negative regulator of sphingolipid synthesis.
C5orf22 protein networkhttps://string-db.org/network/9606.ENSP00000326879UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family.
LIMS2 protein networkhttps://string-db.org/network/9606.ENSP00000326888LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface re [...]
SERTAD2 protein networkhttps://string-db.org/network/9606.ENSP00000326933SERTA domain-containing protein 2; Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivato [...]
FTSJ1 protein networkhttps://string-db.org/network/9606.ENSP00000326948Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs; Belongs to the c [...]
IMP3 protein networkhttps://string-db.org/network/9606.ENSP00000326981U3 small nucleolar ribonucleoprotein protein IMP3; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processi [...]
CLIP4 protein networkhttps://string-db.org/network/9606.ENSP00000327009CAP-Gly domain containing linker protein family member 4.
RORC protein networkhttps://string-db.org/network/9606.ENSP00000327025Nuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequenc [...]
MAF protein networkhttps://string-db.org/network/9606.ENSP00000327048Transcription factor Maf; Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to cry [...]
LMNB2 protein networkhttps://string-db.org/network/9606.ENSP00000327054Lamin-B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope an [...]
MDH2 protein networkhttps://string-db.org/network/9606.ENSP00000327070Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2.
PCM1 protein networkhttps://string-db.org/network/9606.ENSP00000327077Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Re [...]
EHD3 protein networkhttps://string-db.org/network/9606.ENSP00000327116EH domain-containing protein 3; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding [...]
ZNF354B protein networkhttps://string-db.org/network/9606.ENSP00000327143Zinc finger protein 354B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FLNC protein networkhttps://string-db.org/network/9606.ENSP00000327145Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskele [...]
PRR7 protein networkhttps://string-db.org/network/9606.ENSP00000327168Proline-rich protein 7; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-media [...]
UTP4 protein networkhttps://string-db.org/network/9606.ENSP00000327179U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at [...]
CCT6B protein networkhttps://string-db.org/network/9606.ENSP00000327191T-complex protein 1 subunit zeta-2; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
SENP5 protein networkhttps://string-db.org/network/9606.ENSP00000327197Sentrin-specific protease 5; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targ [...]
NRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000327213Nuclear receptor-interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone recep [...]
ATP13A2 protein networkhttps://string-db.org/network/9606.ENSP00000327214Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintena [...]
TMCO5A protein networkhttps://string-db.org/network/9606.ENSP00000327234Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family.
VIPR1 protein networkhttps://string-db.org/network/9606.ENSP00000327246Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > [...]
NOS2 protein networkhttps://string-db.org/network/9606.ENSP00000327251Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal act [...]
PPM1A protein networkhttps://string-db.org/network/9606.ENSP00000327255Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear ex [...]
NDUFV2 protein networkhttps://string-db.org/network/9606.ENSP00000327268NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minima [...]
ITGA11 protein networkhttps://string-db.org/network/9606.ENSP00000327290Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen.
THNSL2 protein networkhttps://string-db.org/network/9606.ENSP00000327323Threonine synthase-like 2; [Isoform 1]: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and [...]
BGN protein networkhttps://string-db.org/network/9606.ENSP00000327336Biglycan; May be involved in collagen fiber assembly.
IGIP protein networkhttps://string-db.org/network/9606.ENSP00000327344IgA-inducing protein homolog; Enhances IgA secretion from B-cells stimulated via CD40.
COL10A1 protein networkhttps://string-db.org/network/9606.ENSP00000327368Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.
GPR39 protein networkhttps://string-db.org/network/9606.ENSP00000327417G-protein coupled receptor 39; Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. I [...]
HBG1 protein networkhttps://string-db.org/network/9606.ENSP00000327431Hemoglobin subunit gamma 1.
SETD3 protein networkhttps://string-db.org/network/9606.ENSP00000327436Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscl [...]
BMP8A protein networkhttps://string-db.org/network/9606.ENSP00000327440Bone morphogenetic protein 8A; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...]
ACSM2B protein networkhttps://string-db.org/network/9606.ENSP00000327453Acyl-coenzyme A synthetase ACSM2B, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chai [...]
APOBEC3B protein networkhttps://string-db.org/network/9606.ENSP00000327459DNA dC->dU-editing enzyme APOBEC-3B; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
SMDT1 protein networkhttps://string-db.org/network/9606.ENSP00000327467Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required t [...]
KLHDC8B protein networkhttps://string-db.org/network/9606.ENSP00000327468Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stabilit [...]
TSEN54 protein networkhttps://string-db.org/network/9606.ENSP00000327487tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. I [...]
C16orf54 protein networkhttps://string-db.org/network/9606.ENSP00000327506Transmembrane protein C16orf54; Chromosome 16 open reading frame 54.
STAC2 protein networkhttps://string-db.org/network/9606.ENSP00000327509SH3 and cysteine-rich domain-containing protein 2; Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel [...]
CSF1 protein networkhttps://string-db.org/network/9606.ENSP00000327513Processed macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especial [...]
OR4F6 protein networkhttps://string-db.org/network/9606.ENSP00000327525Olfactory receptor 4F6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LYG2 protein networkhttps://string-db.org/network/9606.ENSP00000327533Lysozyme g-like protein 2; May act as a potent antibacterial protein that may play a role in the innate immunity; Belongs to the glycosyl hydrolase 23 family.
ZNF534 protein networkhttps://string-db.org/network/9606.ENSP00000327538Zinc finger protein 534; May be involved in transcriptional regulation.
NPTXR protein networkhttps://string-db.org/network/9606.ENSP00000327545Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of [...]
ACP7 protein networkhttps://string-db.org/network/9606.ENSP00000327557Acid phosphatase 7, tartrate resistant; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
SLC22A10 protein networkhttps://string-db.org/network/9606.ENSP00000327569Solute carrier family 22 member 10.
GLUD2 protein networkhttps://string-db.org/network/9606.ENSP00000327589Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
CLEC4G protein networkhttps://string-db.org/network/9606.ENSP00000327599C-type lectin domain family 4 member G; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro. (Microbial infection) Acts as a recepto [...]
TRIM49 protein networkhttps://string-db.org/network/9606.ENSP00000327604Tripartite motif containing 49; Belongs to the TRIM/RBCC family.
ADAMTSL5 protein networkhttps://string-db.org/network/9606.ENSP00000327608ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM).
KCNK12 protein networkhttps://string-db.org/network/9606.ENSP00000327611Potassium channel subfamily K member 12; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional [...]
VPS33B protein networkhttps://string-db.org/network/9606.ENSP00000327650Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysos [...]
LRRC14B protein networkhttps://string-db.org/network/9606.ENSP00000327675Leucine-rich repeat-containing protein 14B; Leucine rich repeat containing 14B; Belongs to the PRAME family. LRRC14 subfamily.
GRIK1 protein networkhttps://string-db.org/network/9606.ENSP00000327687Glutamate receptor ionotropic, kainate 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitato [...]
AP2A2 protein networkhttps://string-db.org/network/9606.ENSP00000327694AP-2 complex subunit alpha-2; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathw [...]
TAS2R60 protein networkhttps://string-db.org/network/9606.ENSP00000327724Taste receptor type 2 member 60; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
C7orf61 protein networkhttps://string-db.org/network/9606.ENSP00000327732Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61.
TRIML1 protein networkhttps://string-db.org/network/9606.ENSP00000327738Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.
NKX2-5 protein networkhttps://string-db.org/network/9606.ENSP00000327758Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds [...]
CLASP2 protein networkhttps://string-db.org/network/9606.ENSP00000327760CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating fr [...]
NLRP10 protein networkhttps://string-db.org/network/9606.ENSP00000327763NACHT, LRR and PYD domains-containing protein 10; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by F [...]
IZUMO1 protein networkhttps://string-db.org/network/9606.ENSP00000327786Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a [...]
DCAF4L1 protein networkhttps://string-db.org/network/9606.ENSP00000327796DDB1- and CUL4-associated factor 4-like protein 1; DDB1 and CUL4 associated factor 4 like 1.
P4HB protein networkhttps://string-db.org/network/9606.ENSP00000327801Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves dis [...]
XPOT protein networkhttps://string-db.org/network/9606.ENSP00000327821Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear po [...]
IFNLR1 protein networkhttps://string-db.org/network/9606.ENSP00000327824Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activ [...]
ATAT1 protein networkhttps://string-db.org/network/9606.ENSP00000327832Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynami [...]
SH2D7 protein networkhttps://string-db.org/network/9606.ENSP00000327846SH2 domain containing 7.
INTS5 protein networkhttps://string-db.org/network/9606.ENSP00000327889Integrator complex subunit 5; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
IL3RA protein networkhttps://string-db.org/network/9606.ENSP00000327890Interleukin-3 receptor subunit alpha; This is a receptor for interleukin-3.
ACSM5 protein networkhttps://string-db.org/network/9606.ENSP00000327916Acyl-coenzyme A synthetase ACSM5, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Belongs to the ATP-dependent AMP-b [...]
SLC5A2 protein networkhttps://string-db.org/network/9606.ENSP00000327943Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
C19orf71 protein networkhttps://string-db.org/network/9606.ENSP00000327950Uncharacterized protein C19orf71; Chromosome 19 open reading frame 71.
TGIF1 protein networkhttps://string-db.org/network/9606.ENSP00000327959Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR [...]
SNAI3 protein networkhttps://string-db.org/network/9606.ENSP00000327968Zinc finger protein SNAI3; Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the [...]
DHRS7C protein networkhttps://string-db.org/network/9606.ENSP00000327975Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase.
TRIM50 protein networkhttps://string-db.org/network/9606.ENSP00000327994E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induce [...]
YAF2 protein networkhttps://string-db.org/network/9606.ENSP00000328004YY1-associated factor 2; Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysi [...]
TNFAIP8L3 protein networkhttps://string-db.org/network/9606.ENSP00000328016Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- b [...]
SRPRA protein networkhttps://string-db.org/network/9606.ENSP00000328023Signal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targetin [...]
DGAT2L6 protein networkhttps://string-db.org/network/9606.ENSP00000328036Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity [...]
RLIM protein networkhttps://string-db.org/network/9606.ENSP00000328059E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation [...]
SPEM2 protein networkhttps://string-db.org/network/9606.ENSP00000328061Uncharacterized protein SPEM2; SPEM family member 2.
C6orf58 protein networkhttps://string-db.org/network/9606.ENSP00000328069Protein LEG1 homolog; May be involved in early liver development.
GLTPD2 protein networkhttps://string-db.org/network/9606.ENSP00000328070Glycolipid transfer protein domain containing 2; Belongs to the GLTP family.
WDR53 protein networkhttps://string-db.org/network/9606.ENSP00000328079WD repeat domain 53; Belongs to the WD repeat WDR53 family.
ARHGEF37 protein networkhttps://string-db.org/network/9606.ENSP00000328083Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF).
PAWR protein networkhttps://string-db.org/network/9606.ENSP00000328088PRKC apoptosis WT1 regulator protein; Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of [...]
IL25 protein networkhttps://string-db.org/network/9606.ENSP00000328111Interleukin-25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses; Belongs to the IL-17 [...]
MCF2L2 protein networkhttps://string-db.org/network/9606.ENSP00000328118Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor. Belongs to the MCF2 family.
IL20RB protein networkhttps://string-db.org/network/9606.ENSP00000328133Interleukin-20 receptor subunit beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
MT1E protein networkhttps://string-db.org/network/9606.ENSP00000328137Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.
JAG2 protein networkhttps://string-db.org/network/9606.ENSP00000328169Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
PIF1 protein networkhttps://string-db.org/network/9606.ENSP00000328174ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) [...]
NOG protein networkhttps://string-db.org/network/9606.ENSP00000328181Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formati [...]
CLN8 protein networkhttps://string-db.org/network/9606.ENSP00000328182Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.
FBXO21 protein networkhttps://string-db.org/network/9606.ENSP00000328187F-box only protein 21; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
TRAIP protein networkhttps://string-db.org/network/9606.ENSP00000328203E3 ubiquitin-protein ligase TRAIP; E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- a [...]
TNFRSF18 protein networkhttps://string-db.org/network/9606.ENSP00000328207Tumor necrosis factor receptor superfamily member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-c [...]
OR56A4 protein networkhttps://string-db.org/network/9606.ENSP00000328215Olfactory receptor 56A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CDCA2 protein networkhttps://string-db.org/network/9606.ENSP00000328228Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts [...]
FFAR3 protein networkhttps://string-db.org/network/9606.ENSP00000328230Free fatty acid receptor 3; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulatio [...]
ELOA3D protein networkhttps://string-db.org/network/9606.ENSP00000328232Elongin-A3 member D; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. [...]
KNTC1 protein networkhttps://string-db.org/network/9606.ENSP00000328236Kinetochore-associated protein 1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-M [...]
ZNF71 protein networkhttps://string-db.org/network/9606.ENSP00000328245Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation.
RIOX2 protein networkhttps://string-db.org/network/9606.ENSP00000328251Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 ( [...]
HMG20B protein networkhttps://string-db.org/network/9606.ENSP00000328269High mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promot [...]
KRTAP4-6 protein networkhttps://string-db.org/network/9606.ENSP00000328270Keratin associated protein 4-6.
B4GALNT4 protein networkhttps://string-db.org/network/9606.ENSP00000328277N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-lin [...]
RNF123 protein networkhttps://string-db.org/network/9606.ENSP00000328287E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which [...]
FAM47B protein networkhttps://string-db.org/network/9606.ENSP00000328307Protein FAM47B; Family with sequence similarity 47 member B; Belongs to the FAM47 family.
PTTG1IP protein networkhttps://string-db.org/network/9606.ENSP00000328325Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation.
XKR4 protein networkhttps://string-db.org/network/9606.ENSP00000328326XK-related protein 4; XK related 4.
ASB7 protein networkhttps://string-db.org/network/9606.ENSP00000328327Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
CEND1 protein networkhttps://string-db.org/network/9606.ENSP00000328336Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation.
RNF135 protein networkhttps://string-db.org/network/9606.ENSP00000328340E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the an [...]
FAM110C protein networkhttps://string-db.org/network/9606.ENSP00000328347Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway.
KRT79 protein networkhttps://string-db.org/network/9606.ENSP00000328358Keratin, type II cytoskeletal 79; Keratin 79; Belongs to the intermediate filament family.
DEFA3 protein networkhttps://string-db.org/network/9606.ENSP00000328359Neutrophil defensin 2; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are th [...]
MAFA protein networkhttps://string-db.org/network/9606.ENSP00000328364Transcription factor MafA; Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to co [...]
VMO1 protein networkhttps://string-db.org/network/9606.ENSP00000328397Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family.
OR6C76 protein networkhttps://string-db.org/network/9606.ENSP00000328402Olfactory receptor 6C76; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PDE6G protein networkhttps://string-db.org/network/9606.ENSP00000328412Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector mol [...]
REC114 protein networkhttps://string-db.org/network/9606.ENSP00000328423Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC3 [...]
TASOR2 protein networkhttps://string-db.org/network/9606.ENSP00000328426Protein TASOR 2; Transcription activation suppressor family member 2; Belongs to the TASOR family.
KRTAP4-8 protein networkhttps://string-db.org/network/9606.ENSP00000328444Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
S1PR5 protein networkhttps://string-db.org/network/9606.ENSP00000328472Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of [...]
CNGA2 protein networkhttps://string-db.org/network/9606.ENSP00000328478Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to b [...]
H2AC14 protein networkhttps://string-db.org/network/9606.ENSP00000328484Histone H2A type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
CCDC87 protein networkhttps://string-db.org/network/9606.ENSP00000328487Coiled-coil domain-containing protein 87; Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fer [...]
KCNA4 protein networkhttps://string-db.org/network/9606.ENSP00000328511Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective [...]
ZNF696 protein networkhttps://string-db.org/network/9606.ENSP00000328515Zinc finger protein 696; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DENND5A protein networkhttps://string-db.org/network/9606.ENSP00000328524DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound R [...]
DNMT3B protein networkhttps://string-db.org/network/9606.ENSP00000328547DNA (cytosine-5)-methyltransferase 3B; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coord [...]
RAB28 protein networkhttps://string-db.org/network/9606.ENSP00000328551Ras-related protein Rab-28; RAB28, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family.
GLRX5 protein networkhttps://string-db.org/network/9606.ENSP00000328570Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an [...]
SIX6 protein networkhttps://string-db.org/network/9606.ENSP00000328596Homeobox protein SIX6; May be involved in eye development.
HOXD1 protein networkhttps://string-db.org/network/9606.ENSP00000328598Homeobox protein Hox-D1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
NRROS protein networkhttps://string-db.org/network/9606.ENSP00000328625Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system (By similarity). Re [...]
C2CD4C protein networkhttps://string-db.org/network/9606.ENSP00000328677C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family.
MOB2 protein networkhttps://string-db.org/network/9606.ENSP00000328694MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L; Belongs to the MOB1/phocein family.
CABCOCO1 protein networkhttps://string-db.org/network/9606.ENSP00000328698Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement.
RXFP3 protein networkhttps://string-db.org/network/9606.ENSP00000328708Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.
FOXK1 protein networkhttps://string-db.org/network/9606.ENSP00000328720Forkhead box protein K1; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recog [...]
SELENOF protein networkhttps://string-db.org/network/9606.ENSP00000328729Selenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic r [...]
PRR23B protein networkhttps://string-db.org/network/9606.ENSP00000328768Proline-rich protein 23B; Proline rich 23B; Belongs to the PRR23 family.
HEXIM1 protein networkhttps://string-db.org/network/9606.ENSP00000328773Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP com [...]
EFNA5 protein networkhttps://string-db.org/network/9606.ENSP00000328777Ephrin-A5; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...]
KCNH8 protein networkhttps://string-db.org/network/9606.ENSP00000328813Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties [...]
GPR132 protein networkhttps://string-db.org/network/9606.ENSP00000328818Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G [...]
TOP1MT protein networkhttps://string-db.org/network/9606.ENSP00000328835DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of t [...]
RBM10 protein networkhttps://string-db.org/network/9606.ENSP00000328848RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for pol [...]
NOC4L protein networkhttps://string-db.org/network/9606.ENSP00000328854Nucleolar complex associated 4 homolog; Belongs to the CBF/MAK21 family.
TRAK2 protein networkhttps://string-db.org/network/9606.ENSP00000328875Trafficking kinesin-binding protein 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR; Belongs to the milton family.
OR52E6 protein networkhttps://string-db.org/network/9606.ENSP00000328878Olfactory receptor 52E6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
KANK3 protein networkhttps://string-db.org/network/9606.ENSP00000328923KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization.
HOXB4 protein networkhttps://string-db.org/network/9606.ENSP00000328928Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
AFMID protein networkhttps://string-db.org/network/9606.ENSP00000328938Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized [...]
SLX1B protein networkhttps://string-db.org/network/9606.ENSP00000328940SLX1 homolog B, structure-specific endonuclease subunit.
SCN5A protein networkhttps://string-db.org/network/9606.ENSP00000328968Sodium channel protein type 5 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...]
RPH3AL protein networkhttps://string-db.org/network/9606.ENSP00000328977Rab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epit [...]
CHST6 protein networkhttps://string-db.org/network/9606.ENSP00000328983Carbohydrate sulfotransferase 6; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...]
PAXBP1 protein networkhttps://string-db.org/network/9606.ENSP00000328992PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyl [...]
TRAK1 protein networkhttps://string-db.org/network/9606.ENSP00000328998Trafficking kinesin-binding protein 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors. Involved in mito [...]
HAX1 protein networkhttps://string-db.org/network/9606.ENSP00000329002HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. [...]
SLC25A18 protein networkhttps://string-db.org/network/9606.ENSP00000329033Mitochondrial glutamate carrier 2; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
FAM174B protein networkhttps://string-db.org/network/9606.ENSP00000329040Membrane protein FAM174B; Essential for Golgi structural integrity.
OR4C46 protein networkhttps://string-db.org/network/9606.ENSP00000329056Olfactory receptor 4C46; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TPH2 protein networkhttps://string-db.org/network/9606.ENSP00000329093Tryptophan hydroxylase 2.
PHF6 protein networkhttps://string-db.org/network/9606.ENSP00000329097PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.
LIN9 protein networkhttps://string-db.org/network/9606.ENSP00000329102Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expres [...]
BPY2 protein networkhttps://string-db.org/network/9606.ENSP00000329106Basic charge Y-linked 2.
PRKCH protein networkhttps://string-db.org/network/9606.ENSP00000329127Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in ker [...]
C1QTNF12 protein networkhttps://string-db.org/network/9606.ENSP00000329137Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses [...]
CREB3L2 protein networkhttps://string-db.org/network/9606.ENSP00000329140Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, in [...]
OR6C70 protein networkhttps://string-db.org/network/9606.ENSP00000329153Olfactory receptor 6C70; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CLRN1 protein networkhttps://string-db.org/network/9606.ENSP00000329158Clarin-1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina; Belongs to the cla [...]
KRT36 protein networkhttps://string-db.org/network/9606.ENSP00000329165Keratin, type I cuticular Ha6; Keratin 36; Belongs to the intermediate filament family.
POU3F2 protein networkhttps://string-db.org/network/9606.ENSP00000329170POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consist [...]
STAC3 protein networkhttps://string-db.org/network/9606.ENSP00000329200SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. [...]
SIVA1 protein networkhttps://string-db.org/network/9606.ENSP00000329213Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-media [...]
ST6GALNAC3 protein networkhttps://string-db.org/network/9606.ENSP00000329214Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-a [...]
FMNL1 protein networkhttps://string-db.org/network/9606.ENSP00000329219Formin-like protein 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization [...]
KRT7 protein networkhttps://string-db.org/network/9606.ENSP00000329243Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA [...]
ZNF662 protein networkhttps://string-db.org/network/9606.ENSP00000329264Zinc finger protein 662; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SNN protein networkhttps://string-db.org/network/9606.ENSP00000329287Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation.
GKN2 protein networkhttps://string-db.org/network/9606.ENSP00000329292Gastrokine-2; Gastrokine 2.
NXPH3 protein networkhttps://string-db.org/network/9606.ENSP00000329295Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family.
IGLL1 protein networkhttps://string-db.org/network/9606.ENSP00000329312Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development.
TMEM121B protein networkhttps://string-db.org/network/9606.ENSP00000329318Transmembrane protein 121B.
SP1 protein networkhttps://string-db.org/network/9606.ENSP00000329357Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and reg [...]
CCDC137 protein networkhttps://string-db.org/network/9606.ENSP00000329360Coiled-coil domain containing 137.
SERPINA7 protein networkhttps://string-db.org/network/9606.ENSP00000329374Thyroxine-binding globulin; Major thyroid hormone transport protein in serum; Belongs to the serpin family.
GP1BA protein networkhttps://string-db.org/network/9606.ENSP00000329380Platelet glycoprotein Ib alpha chain; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to [...]
PCP4 protein networkhttps://string-db.org/network/9606.ENSP00000329403Calmodulin regulator protein PCP4; Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may pla [...]
COPB2 protein networkhttps://string-db.org/network/9606.ENSP00000329419Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynth [...]
SLC25A21 protein networkhttps://string-db.org/network/9606.ENSP00000329452Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a l [...]
SIRT7 protein networkhttps://string-db.org/network/9606.ENSP00000329466NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on [...]
KDELR1 protein networkhttps://string-db.org/network/9606.ENSP00000329471ER lumen protein-retaining receptor 1; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Gol [...]
FAM187A protein networkhttps://string-db.org/network/9606.ENSP00000329499Ig-like V-type domain-containing protein FAM187A; Family with sequence similarity 187 member A.
CD300C protein networkhttps://string-db.org/network/9606.ENSP00000329507CMRF35-like molecule 6; CD300c molecule; Belongs to the CD300 family.
SPDYE4 protein networkhttps://string-db.org/network/9606.ENSP00000329522Speedy protein E4; speedy/RINGO cell cycle regulator family member E4; Belongs to the Speedy/Ringo family.
TRARG1 protein networkhttps://string-db.org/network/9606.ENSP00000329548Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial [...]
TMEM89 protein networkhttps://string-db.org/network/9606.ENSP00000329557Transmembrane protein 89.
GRPEL2 protein networkhttps://string-db.org/network/9606.ENSP00000329558GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mit [...]
SPDYE3 protein networkhttps://string-db.org/network/9606.ENSP00000329565Speedy protein E3; speedy/RINGO cell cycle regulator family member E3.
ODF3L1 protein networkhttps://string-db.org/network/9606.ENSP00000329584Outer dense fiber of sperm tails 3 like 1; Belongs to the ODF3 family.
YBEY protein networkhttps://string-db.org/network/9606.ENSP00000329614Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation.
ZNF804B protein networkhttps://string-db.org/network/9606.ENSP00000329638Zinc finger protein 804B.
ACTL10 protein networkhttps://string-db.org/network/9606.ENSP00000329647Actin-like protein 10; Actin like 10; Belongs to the actin family.
GALNT17 protein networkhttps://string-db.org/network/9606.ENSP00000329654Polypeptide N-acetylgalactosaminyltransferase 17; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or th [...]
H1-10 protein networkhttps://string-db.org/network/9606.ENSP00000329662Histone H1x; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.
SHC4 protein networkhttps://string-db.org/network/9606.ENSP00000329668SHC-transforming protein 4; Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
GALR2 protein networkhttps://string-db.org/network/9606.ENSP00000329684Galanin receptor type 2; Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/pr [...]
PLPP2 protein networkhttps://string-db.org/network/9606.ENSP00000329697Phospholipid phosphatase 2; Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatid [...]
DRG1 protein networkhttps://string-db.org/network/9606.ENSP00000329715Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is [...]
CPNE8 protein networkhttps://string-db.org/network/9606.ENSP00000329748Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family.
ATP6V0C protein networkhttps://string-db.org/network/9606.ENSP00000329757V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of [...]
ZNF85 protein networkhttps://string-db.org/network/9606.ENSP00000329793Zinc finger protein 85; May be a transcriptional repressor.
TCEAL7 protein networkhttps://string-db.org/network/9606.ENSP00000329794Transcription elongation factor A protein-like 7; Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its ta [...]
CADM1 protein networkhttps://string-db.org/network/9606.ENSP00000329797Cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent mann [...]
ZAR1 protein networkhttps://string-db.org/network/9606.ENSP00000329803Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity).
SPATA31A6 protein networkhttps://string-db.org/network/9606.ENSP00000329825Spermatogenesis-associated protein 31A6; May play a role in spermatogenesis; Belongs to the SPATA31 family.
GALNT9 protein networkhttps://string-db.org/network/9606.ENSP00000329846Polypeptide N-acetylgalactosaminyltransferase 9; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threon [...]
TRMT12 protein networkhttps://string-db.org/network/9606.ENSP00000329858tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guano [...]
CCDC172 protein networkhttps://string-db.org/network/9606.ENSP00000329860Coiled-coil domain containing 172.
TPO protein networkhttps://string-db.org/network/9606.ENSP00000329869Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
PHACTR1 protein networkhttps://string-db.org/network/9606.ENSP00000329880Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, ce [...]
DEFA5 protein networkhttps://string-db.org/network/9606.ENSP00000329890Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert [...]
IQCF2 protein networkhttps://string-db.org/network/9606.ENSP00000329904IQ motif containing F2.
PSMG1 protein networkhttps://string-db.org/network/9606.ENSP00000329915Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 prot [...]
MEX3B protein networkhttps://string-db.org/network/9606.ENSP00000329918RNA-binding protein MEX3B; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
MCEMP1 protein networkhttps://string-db.org/network/9606.ENSP00000329920Mast cell expressed membrane protein 1.
CALHM1 protein networkhttps://string-db.org/network/9606.ENSP00000329926Calcium homeostasis modulator protein 1; Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes (By similarity). Specifically presen [...]
LGALS9C protein networkhttps://string-db.org/network/9606.ENSP00000329932Galectin-9C; Binds galactosides.
PHF12 protein networkhttps://string-db.org/network/9606.ENSP00000329933PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an assoc [...]
LRRC36 protein networkhttps://string-db.org/network/9606.ENSP00000329943Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36.
TBK1 protein networkhttps://string-db.org/network/9606.ENSP00000329967Serine/threonine-protein kinase TBK1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by v [...]
OR4F16 protein networkhttps://string-db.org/network/9606.ENSP00000329982Olfactory receptor 4F3/4F16/4F29; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IFNL1 protein networkhttps://string-db.org/network/9606.ENSP00000329991Interferon lambda-1; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...]
FAM186A protein networkhttps://string-db.org/network/9606.ENSP00000329995Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family.
PIWIL3 protein networkhttps://string-db.org/network/9606.ENSP00000330031Piwi-like protein 3; May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRN [...]
UPP1 protein networkhttps://string-db.org/network/9606.ENSP00000330032Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as [...]
OR4Q3 protein networkhttps://string-db.org/network/9606.ENSP00000330049Olfactory receptor 4Q3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MFSD6L protein networkhttps://string-db.org/network/9606.ENSP00000330051Major facilitator superfamily domain containing 6 like.
H1-5 protein networkhttps://string-db.org/network/9606.ENSP00000330074Histone H1.5; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...]
OGFOD3 protein networkhttps://string-db.org/network/9606.ENSP000003300752-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family.
FBXL6 protein networkhttps://string-db.org/network/9606.ENSP00000330098F-box/LRR-repeat protein 6; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
KRT76 protein networkhttps://string-db.org/network/9606.ENSP00000330101Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification. Belongs to the intermediate filament family.
GRID1 protein networkhttps://string-db.org/network/9606.ENSP00000330148Glutamate receptor ionotropic, delta-1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu [...]
RSRC2 protein networkhttps://string-db.org/network/9606.ENSP00000330188Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family.
POU6F1 protein networkhttps://string-db.org/network/9606.ENSP00000330190POU domain, class 6, transcription factor 1; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3').
SLC6A17 protein networkhttps://string-db.org/network/9606.ENSP00000330199Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of [...]
BTNL9 protein networkhttps://string-db.org/network/9606.ENSP00000330200Butyrophilin-like protein 9; Butyrophilin like 9; Belongs to the immunoglobulin superfamily. BTN/MOG family.
SOX1 protein networkhttps://string-db.org/network/9606.ENSP00000330218Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins an [...]
SPSB1 protein networkhttps://string-db.org/network/9606.ENSP00000330221SPRY domain-containing SOCS box protein 1; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitina [...]
CASP9 protein networkhttps://string-db.org/network/9606.ENSP00000330237Caspase-9 subunit p10; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves an [...]
CCDC34 protein networkhttps://string-db.org/network/9606.ENSP00000330240Coiled-coil domain containing 34.
NT5DC4 protein networkhttps://string-db.org/network/9606.ENSP000003302475'-nucleotidase domain containing 4; Belongs to the 5'(3')-deoxyribonucleotidase family.
RESP18 protein networkhttps://string-db.org/network/9606.ENSP00000330269Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs.
PLEKHH1 protein networkhttps://string-db.org/network/9606.ENSP00000330278Pleckstrin homology, MyTH4 and FERM domain containing H1.
NPBWR1 protein networkhttps://string-db.org/network/9606.ENSP00000330284Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food inta [...]
TRAPPC6B protein networkhttps://string-db.org/network/9606.ENSP00000330289Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved i [...]
OR52L1 protein networkhttps://string-db.org/network/9606.ENSP00000330338Olfactory receptor 52L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SOCS3 protein networkhttps://string-db.org/network/9606.ENSP00000330341Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of [...]
DDX41 protein networkhttps://string-db.org/network/9606.ENSP00000330349Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post- transcriptional gene expression. May be involved in pre-mRNA splicing. Belongs to the DEAD [...]
C8orf33 protein networkhttps://string-db.org/network/9606.ENSP00000330361UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family.
WDR5B protein networkhttps://string-db.org/network/9606.ENSP00000330381WD repeat-containing protein 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex; Belongs to the WD repeat WDR5/wds family.
PDGFB protein networkhttps://string-db.org/network/9606.ENSP00000330382Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Poten [...]
PTRHD1 protein networkhttps://string-db.org/network/9606.ENSP00000330389peptidyl-tRNA hydrolase domain containing 1.
SPRR3 protein networkhttps://string-db.org/network/9606.ENSP00000330391Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes.
LEPR protein networkhttps://string-db.org/network/9606.ENSP00000330393Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STA [...]
C1QTNF8 protein networkhttps://string-db.org/network/9606.ENSP00000330426Complement C1q tumor necrosis factor-related protein 8; May play a role as ligand of RXFP1.
FAM83F protein networkhttps://string-db.org/network/9606.ENSP00000330432Protein FAM83F; Family with sequence similarity 83 member F.
TM2D3 protein networkhttps://string-db.org/network/9606.ENSP00000330433TM2 domain containing 3.
PLB1 protein networkhttps://string-db.org/network/9606.ENSP00000330442Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Prefer [...]
DDX59 protein networkhttps://string-db.org/network/9606.ENSP00000330460Probable ATP-dependent RNA helicase DDX59; DEAD-box helicase 59.
TMPRSS11B protein networkhttps://string-db.org/network/9606.ENSP00000330475Transmembrane protease serine 11B; Serine protease.
AMY1B protein networkhttps://string-db.org/network/9606.ENSP00000330484Amylase alpha 1B; Belongs to the glycosyl hydrolase 13 family.
CXorf38 protein networkhttps://string-db.org/network/9606.ENSP00000330488Uncharacterized protein CXorf38; Chromosome X open reading frame 38.
CTHRC1 protein networkhttps://string-db.org/network/9606.ENSP00000330523Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition.
MAPK8IP2 protein networkhttps://string-db.org/network/9606.ENSP00000330572C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...]
MT1H protein networkhttps://string-db.org/network/9606.ENSP00000330587Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
HHIPL1 protein networkhttps://string-db.org/network/9606.ENSP00000330601HHIP-like protein 1; HHIP like 1; Belongs to the HHIP family.
HS3ST4 protein networkhttps://string-db.org/network/9606.ENSP00000330606Heparan sulfate glucosamine 3-O-sulfotransferase 4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamin [...]
MRGPRG protein networkhttps://string-db.org/network/9606.ENSP00000330612Mas-related G-protein coupled receptor member G; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); Belongs to th [...]
RTN4RL1 protein networkhttps://string-db.org/network/9606.ENSP00000330631Reticulon-4 receptor-like 1; Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Con [...]
CNTN2 protein networkhttps://string-db.org/network/9606.ENSP00000330633Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at t [...]
PAPPA protein networkhttps://string-db.org/network/9606.ENSP00000330658Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cle [...]
NSMCE3 protein networkhttps://string-db.org/network/9606.ENSP00000330694Non-structural maintenance of chromosomes element 3 homolog; Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex [...]
P2RX7 protein networkhttps://string-db.org/network/9606.ENSP00000330696P2X purinoceptor 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecul [...]
KRTAP11-1 protein networkhttps://string-db.org/network/9606.ENSP00000330720Keratin-associated protein 11-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
COA5 protein networkhttps://string-db.org/network/9606.ENSP00000330730Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process.
NDUFA12 protein networkhttps://string-db.org/network/9606.ENSP00000330737NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...]
KRTAP20-2 protein networkhttps://string-db.org/network/9606.ENSP00000330746Keratin-associated protein 20-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
BRWD1 protein networkhttps://string-db.org/network/9606.ENSP00000330753Bromodomain and WD repeat-containing protein 1; May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and [...]
OTOL1 protein networkhttps://string-db.org/network/9606.ENSP00000330808Otolin-1; Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts [...]
IFITM1 protein networkhttps://string-db.org/network/9606.ENSP00000330825Interferon-induced transmembrane protein 1; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral f [...]
ZNF775 protein networkhttps://string-db.org/network/9606.ENSP00000330838Zinc finger protein 775; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RGPD6 protein networkhttps://string-db.org/network/9606.ENSP00000330842RANBP2 like and GRIP domain containing 6.
OPCML protein networkhttps://string-db.org/network/9606.ENSP00000330862Opioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family.
FANCF protein networkhttps://string-db.org/network/9606.ENSP00000330875Fanconi anemia group F protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...]
KPNA7 protein networkhttps://string-db.org/network/9606.ENSP00000330878Importin subunit alpha-8; Functions in nuclear protein import; Belongs to the importin alpha family.
POLR2J2 protein networkhttps://string-db.org/network/9606.ENSP00000330898DNA-directed RNA polymerase II subunit RPB11-b1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of R [...]
OR2T34 protein networkhttps://string-db.org/network/9606.ENSP00000330904Olfactory receptor 2T34; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PGP protein networkhttps://string-db.org/network/9606.ENSP00000330918Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic inte [...]
TMED9 protein networkhttps://string-db.org/network/9606.ENSP00000330945Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport invo [...]
IL1R2 protein networkhttps://string-db.org/network/9606.ENSP00000330959Interleukin-1 receptor type 2, membrane form; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing it [...]
C10orf120 protein networkhttps://string-db.org/network/9606.ENSP00000331012Uncharacterized protein C10orf120; Chromosome 10 open reading frame 120.
RPS27L protein networkhttps://string-db.org/network/9606.ENSP00000331019Ribosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family.
OLIG2 protein networkhttps://string-db.org/network/9606.ENSP00000331040Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. F [...]
ENKUR protein networkhttps://string-db.org/network/9606.ENSP00000331044Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.
VSTM4 protein networkhttps://string-db.org/network/9606.ENSP00000331062V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L- VGCC) currents in retinal photoreceptors.
PPP1R27 protein networkhttps://string-db.org/network/9606.ENSP00000331065Protein phosphatase 1 regulatory subunit 27; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
ODF4 protein networkhttps://string-db.org/network/9606.ENSP00000331086Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskel [...]
TSSC4 protein networkhttps://string-db.org/network/9606.ENSP00000331087Protein TSSC4; Tumor suppressing subtransferable candidate 4.
IP6K2 protein networkhttps://string-db.org/network/9606.ENSP00000331103Inositol hexakisphosphate kinase 2; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).
PEX26 protein networkhttps://string-db.org/network/9606.ENSP00000331106Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required fo [...]
ZNRD1 protein networkhttps://string-db.org/network/9606.ENSP00000331111DNA-directed RNA polymerase I subunit RPA12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
BOLA2 protein networkhttps://string-db.org/network/9606.ENSP00000331127bolA family member 2.
MXI1 protein networkhttps://string-db.org/network/9606.ENSP00000331152Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus ant [...]
LMNTD2 protein networkhttps://string-db.org/network/9606.ENSP00000331167Lamin tail domain containing 2.
CD8B protein networkhttps://string-db.org/network/9606.ENSP00000331172T-cell surface glycoprotein CD8 beta chain; CD8b molecule.
HGS protein networkhttps://string-db.org/network/9606.ENSP00000331201Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA [...]
C11orf54 protein networkhttps://string-db.org/network/9606.ENSP00000331209Ester hydrolase C11orf54; Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate.
BCAN protein networkhttps://string-db.org/network/9606.ENSP00000331210Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain [...]
RBM43 protein networkhttps://string-db.org/network/9606.ENSP00000331211RNA binding motif protein 43.
KREMEN1 protein networkhttps://string-db.org/network/9606.ENSP00000331242Kremen protein 1; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, [...]
POMK protein networkhttps://string-db.org/network/9606.ENSP00000331258Protein O-mannose kinase; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-ace [...]
ANKRD45 protein networkhttps://string-db.org/network/9606.ENSP00000331268Ankyrin repeat domain 45.
UBALD2 protein networkhttps://string-db.org/network/9606.ENSP00000331298UBA-like domain-containing protein 2; UBA like domain containing 2; Belongs to the UBALD family.
ELOA2 protein networkhttps://string-db.org/network/9606.ENSP00000331302Elongin-A2; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit [...]
TOB2 protein networkhttps://string-db.org/network/9606.ENSP00000331305Protein Tob2; Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases; Belongs to the BTG family.
MORF4L1 protein networkhttps://string-db.org/network/9606.ENSP00000331310Mortality factor 4-like protein 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...]
GNB1L protein networkhttps://string-db.org/network/9606.ENSP00000331313G protein subunit beta 1 like.
RAB11FIP1 protein networkhttps://string-db.org/network/9606.ENSP00000331342Rab11 family-interacting protein 1; A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in pha [...]
GAST protein networkhttps://string-db.org/network/9606.ENSP00000331358Big gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and inc [...]
SERPINB8 protein networkhttps://string-db.org/network/9606.ENSP00000331368Serpin B8; Has an important role in epithelial desmosome-mediated cell- cell adhesion; Belongs to the serpin family. Ov-serpin subfamily.
BOLA3 protein networkhttps://string-db.org/network/9606.ENSP00000331369BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together w [...]
SERHL2 protein networkhttps://string-db.org/network/9606.ENSP00000331376Serine hydrolase-like protein 2; Probable serine hydrolase. May be related to cell muscle hypertrophy.
KIAA0825 protein networkhttps://string-db.org/network/9606.ENSP00000331385Uncharacterized protein KIAA0825; KIAA0825.
FAM43B protein networkhttps://string-db.org/network/9606.ENSP00000331397Protein FAM43B; Family with sequence similarity 43 member B; Belongs to the FAM43 family.
FBLN7 protein networkhttps://string-db.org/network/9606.ENSP00000331411Fibulin-7; An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as i [...]
MBD3L5 protein networkhttps://string-db.org/network/9606.ENSP00000331435methyl-CpG binding domain protein 3 like 5.
ZNF704 protein networkhttps://string-db.org/network/9606.ENSP00000331462Zinc finger protein 704; Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer.
ZNF84 protein networkhttps://string-db.org/network/9606.ENSP00000331465Zinc finger protein 84; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DBX2 protein networkhttps://string-db.org/network/9606.ENSP00000331470Homeobox protein DBX2; Developing brain homeobox 2.
SYNDIG1L protein networkhttps://string-db.org/network/9606.ENSP00000331474Synapse differentiation-inducing gene protein 1-like; Synapse differentiation inducing 1 like.
CYB5D1 protein networkhttps://string-db.org/network/9606.ENSP00000331479Cytochrome b5 domain containing 1.
NPLOC4 protein networkhttps://string-db.org/network/9606.ENSP00000331487Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER [...]
TEX19 protein networkhttps://string-db.org/network/9606.ENSP00000331500Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates w [...]
FES protein networkhttps://string-db.org/network/9606.ENSP00000331504Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell at [...]
SPATA32 protein networkhttps://string-db.org/network/9606.ENSP00000331532Spermatogenesis-associated protein 32; Spermatogenesis associated 32.
FBLN1 protein networkhttps://string-db.org/network/9606.ENSP00000331544Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important fo [...]
OR1G1 protein networkhttps://string-db.org/network/9606.ENSP00000331545Olfactory receptor 1G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CYLC1 protein networkhttps://string-db.org/network/9606.ENSP00000331556Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
ZNF397 protein networkhttps://string-db.org/network/9606.ENSP00000331577Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor.
C11orf87 protein networkhttps://string-db.org/network/9606.ENSP00000331581Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87.
GPR173 protein networkhttps://string-db.org/network/9606.ENSP00000331600Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20 (By similarity). It mediates the Phoenixin-14 and Phoenixin-20 augmentation of [...]
PRKCD protein networkhttps://string-db.org/network/9606.ENSP00000331602Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death a [...]
IRX3 protein networkhttps://string-db.org/network/9606.ENSP00000331608Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the [...]
IKZF1 protein networkhttps://string-db.org/network/9606.ENSP00000331614DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and act [...]
ZKSCAN2 protein networkhttps://string-db.org/network/9606.ENSP00000331626Zinc finger protein with KRAB and SCAN domains 2; May be involved in transcriptional regulation.
CAPN12 protein networkhttps://string-db.org/network/9606.ENSP00000331636Calpain-12; Calcium-regulated non-lysosomal thiol-protease.
TMEM186 protein networkhttps://string-db.org/network/9606.ENSP00000331640Transmembrane protein 186.
PGBD2 protein networkhttps://string-db.org/network/9606.ENSP00000331643piggyBac transposable element derived 2.
PKP3 protein networkhttps://string-db.org/network/9606.ENSP00000331678Plakophilin-3; May play a role in junctional plaques; Belongs to the beta-catenin family.
DGCR6 protein networkhttps://string-db.org/network/9606.ENSP00000331681Protein DGCR6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
KLHL22 protein networkhttps://string-db.org/network/9606.ENSP00000331682Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) [...]
C12orf60 protein networkhttps://string-db.org/network/9606.ENSP00000331691Uncharacterized protein C12orf60; Chromosome 12 open reading frame 60.
XKR3 protein networkhttps://string-db.org/network/9606.ENSP00000331704XK-related protein 3; XK related 3; Belongs to the XK family.
C16orf72 protein networkhttps://string-db.org/network/9606.ENSP00000331720UPF0472 protein C16orf72; Chromosome 16 open reading frame 72.
KCNH7 protein networkhttps://string-db.org/network/9606.ENSP00000331727Potassium voltage-gated channel subfamily H member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly; Belongs to [...]
RIPPLY3 protein networkhttps://string-db.org/network/9606.ENSP00000331734Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By [...]
SELE protein networkhttps://string-db.org/network/9606.ENSP00000331736E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May h [...]
HOXB2 protein networkhttps://string-db.org/network/9606.ENSP00000331741Homeobox protein Hox-B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
GDF3 protein networkhttps://string-db.org/network/9606.ENSP00000331745Growth/differentiation factor 3; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and me [...]
CALCA protein networkhttps://string-db.org/network/9606.ENSP00000331746Calcitonin; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
RAB12 protein networkhttps://string-db.org/network/9606.ENSP00000331748Ras-related protein Rab-12; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
TBX1 protein networkhttps://string-db.org/network/9606.ENSP00000331791T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).
OR5P2 protein networkhttps://string-db.org/network/9606.ENSP00000331823Olfactory receptor 5P2; Odorant receptor (Potential). May be involved in taste perception.
GAS6 protein networkhttps://string-db.org/network/9606.ENSP00000331831Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6 [...]
NPIPA1 protein networkhttps://string-db.org/network/9606.ENSP00000331843Nuclear pore complex interacting protein family member A1.
PRR14L protein networkhttps://string-db.org/network/9606.ENSP00000331845Protein PRR14L; Proline rich 14 like.
MRPL54 protein networkhttps://string-db.org/network/9606.ENSP00000331849Mitochondrial ribosomal protein L54.
NLRP9 protein networkhttps://string-db.org/network/9606.ENSP00000331857NACHT, LRR and PYD domains-containing protein 9; As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including r [...]
TAS1R1 protein networkhttps://string-db.org/network/9606.ENSP00000331867Taste receptor type 1 member 1; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species ca [...]
PRMT3 protein networkhttps://string-db.org/network/9606.ENSP00000331879Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins.
IDH2 protein networkhttps://string-db.org/network/9606.ENSP00000331897Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belong [...]
EEF1G protein networkhttps://string-db.org/network/9606.ENSP00000331901Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.
COL4A5 protein networkhttps://string-db.org/network/9606.ENSP00000331902Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
DHX34 protein networkhttps://string-db.org/network/9606.ENSP00000331907Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily.
RFLNB protein networkhttps://string-db.org/network/9606.ENSP00000331915Refilin-B; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elem [...]
ZNF789 protein networkhttps://string-db.org/network/9606.ENSP00000331927Zinc finger protein 789; May be involved in transcriptional regulation.
AEN protein networkhttps://string-db.org/network/9606.ENSP00000331944Apoptosis-enhancing nuclease; Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-s [...]
TLCD2 protein networkhttps://string-db.org/network/9606.ENSP00000331965TLC domain-containing protein 2; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyu [...]
CARMIL1 protein networkhttps://string-db.org/network/9606.ENSP00000331983F-actin-uncapping protein LRRC16A; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin [...]
ZGPAT protein networkhttps://string-db.org/network/9606.ENSP00000332013Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting t [...]
PROSER1 protein networkhttps://string-db.org/network/9606.ENSP00000332034Proline and serine rich 1.
CD86 protein networkhttps://string-db.org/network/9606.ENSP00000332049T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a cr [...]
SNX20 protein networkhttps://string-db.org/network/9606.ENSP00000332062Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalizati [...]
MGAT1 protein networkhttps://string-db.org/network/9606.ENSP00000332073Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-gly [...]
NAA38 protein networkhttps://string-db.org/network/9606.ENSP00000332103N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
EFCAB13 protein networkhttps://string-db.org/network/9606.ENSP00000332111EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13.
EPHB3 protein networkhttps://string-db.org/network/9606.ENSP00000332118Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
PRAMEF1 protein networkhttps://string-db.org/network/9606.ENSP00000332134PRAME family member 1; Belongs to the PRAME family.
DZIP1L protein networkhttps://string-db.org/network/9606.ENSP00000332148Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane ; Belongs t [...]
SRARP protein networkhttps://string-db.org/network/9606.ENSP00000332162Steroid receptor-associated and regulated protein; May regulate the transcriptional function of androgen and estrogen receptors.
SPRR4 protein networkhttps://string-db.org/network/9606.ENSP00000332163Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family.
SLIT3 protein networkhttps://string-db.org/network/9606.ENSP00000332164Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
H2AC20 protein networkhttps://string-db.org/network/9606.ENSP00000332194Histone H2A type 2-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
NOP10 protein networkhttps://string-db.org/network/9606.ENSP00000332198H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...]
RFX6 protein networkhttps://string-db.org/network/9606.ENSP00000332208DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 isl [...]
PSG3 protein networkhttps://string-db.org/network/9606.ENSP00000332215Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family.
PMCH protein networkhttps://string-db.org/network/9606.ENSP00000332225Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as [...]
ATP6V0A2 protein networkhttps://string-db.org/network/9606.ENSP00000332247V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi func [...]
ALDH1A3 protein networkhttps://string-db.org/network/9606.ENSP00000332256Aldehyde dehydrogenase family 1 member A3; NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitr [...]
SYNGR1 protein networkhttps://string-db.org/network/9606.ENSP00000332287Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesic [...]
TRIM61 protein networkhttps://string-db.org/network/9606.ENSP00000332288Putative tripartite motif-containing protein 61; Tripartite motif containing 61.
ASCL2 protein networkhttps://string-db.org/network/9606.ENSP00000332293Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
RARB protein networkhttps://string-db.org/network/9606.ENSP00000332296Retinoic acid receptor beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic a [...]
ZNF703 protein networkhttps://string-db.org/network/9606.ENSP00000332325Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates ce [...]
DDX28 protein networkhttps://string-db.org/network/9606.ENSP00000332340Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this [...]
PTCH1 protein networkhttps://string-db.org/network/9606.ENSP00000332353Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's p [...]
COL7A1 protein networkhttps://string-db.org/network/9606.ENSP00000332371Collagen alpha-1(VII) chain; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence [...]
BRICD5 protein networkhttps://string-db.org/network/9606.ENSP00000332389BRICHOS domain containing 5.
TMIGD1 protein networkhttps://string-db.org/network/9606.ENSP00000332404Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative [...]
SDR42E1 protein networkhttps://string-db.org/network/9606.ENSP00000332407Short chain dehydrogenase/reductase family 42E, member 1.
BEST3 protein networkhttps://string-db.org/network/9606.ENSP00000332413Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.
ZSCAN22 protein networkhttps://string-db.org/network/9606.ENSP00000332433Zinc finger and SCAN domain-containing protein 22; May be involved in transcriptional regulation.
CSTF2T protein networkhttps://string-db.org/network/9606.ENSP00000332444Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre- mRNAs (By similar [...]
ADAT3 protein networkhttps://string-db.org/network/9606.ENSP00000332448Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.
CRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000332449Cysteine-rich protein 1; Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
RIPK4 protein networkhttps://string-db.org/network/9606.ENSP00000332454Receptor-interacting serine/threonine-protein kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation.
SPPL2C protein networkhttps://string-db.org/network/9606.ENSP00000332488Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.
OR4N4 protein networkhttps://string-db.org/network/9606.ENSP00000332500Olfactory receptor 4N4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CCR10 protein networkhttps://string-db.org/network/9606.ENSP00000332504C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B [...]
OLFML1 protein networkhttps://string-db.org/network/9606.ENSP00000332511Olfactomedin-like protein 1; Olfactomedin like 1.
SH3BGR protein networkhttps://string-db.org/network/9606.ENSP00000332513SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family.
OTOP2 protein networkhttps://string-db.org/network/9606.ENSP00000332528Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellu [...]
RNLS protein networkhttps://string-db.org/network/9606.ENSP00000332530Renalase; Catalyzes the oxidation of the less abundant 1,2-dihydro- beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in [...]
GRIN2A protein networkhttps://string-db.org/network/9606.ENSP00000332549Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...]
SULT4A1 protein networkhttps://string-db.org/network/9606.ENSP00000332565Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxin [...]
OSBP2 protein networkhttps://string-db.org/network/9606.ENSP00000332576Oxysterol-binding protein 2; Binds 7-ketocholesterol.
NPY2R protein networkhttps://string-db.org/network/9606.ENSP00000332591Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-3 [...]
SPAG16 protein networkhttps://string-db.org/network/9606.ENSP00000332592Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate [...]
ZNF92 protein networkhttps://string-db.org/network/9606.ENSP00000332595Zinc finger protein 92; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CTAG1B protein networkhttps://string-db.org/network/9606.ENSP00000332602Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family.
EIF3C protein networkhttps://string-db.org/network/9606.ENSP00000332604Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
OAF protein networkhttps://string-db.org/network/9606.ENSP00000332613Out at first homolog; Belongs to the OAF family.
FAM169B protein networkhttps://string-db.org/network/9606.ENSP00000332615Protein FAM169B; Family with sequence similarity 169 member B; Belongs to the FAM169 family.
MFSD10 protein networkhttps://string-db.org/network/9606.ENSP00000332646Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non- steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as [...]
ENPP7 protein networkhttps://string-db.org/network/9606.ENSP00000332656Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Converts sphingomyelin to ceramide and phosphocholine. Has also phospholipase C activity and can cleave phosphocholine from palmi [...]
CCR4 protein networkhttps://string-db.org/network/9606.ENSP00000332659C-C chemokine receptor type 4; High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which [...]
CYP2A13 protein networkhttps://string-db.org/network/9606.ENSP00000332679Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenyl [...]
LRP2BP protein networkhttps://string-db.org/network/9606.ENSP00000332681LRP2-binding protein; May act as an adapter that regulates LRP2 function.
KRTAP6-1 protein networkhttps://string-db.org/network/9606.ENSP00000332690Keratin-associated protein 6-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
PURA protein networkhttps://string-db.org/network/9606.ENSP00000332706Transcriptional activator protein Pur-alpha; This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. [...]
COLEC10 protein networkhttps://string-db.org/network/9606.ENSP00000332723Collectin-10; Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of ce [...]
UNC5A protein networkhttps://string-db.org/network/9606.ENSP00000332737Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neu [...]
ZKSCAN8 protein networkhttps://string-db.org/network/9606.ENSP00000332750Zinc finger protein with KRAB and SCAN domains 8; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP11C protein networkhttps://string-db.org/network/9606.ENSP00000332756Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
FUT10 protein networkhttps://string-db.org/network/9606.ENSP00000332757Alpha-(1,3)-fucosyltransferase 10; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family.
NPB protein networkhttps://string-db.org/network/9606.ENSP00000332766Neuropeptide B-23; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.
CLCNKA protein networkhttps://string-db.org/network/9606.ENSP00000332771Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transdu [...]
YIPF7 protein networkhttps://string-db.org/network/9606.ENSP00000332772Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family.
IGDCC3 protein networkhttps://string-db.org/network/9606.ENSP00000332773Immunoglobulin superfamily DCC subclass member 3.
ANO9 protein networkhttps://string-db.org/network/9606.ENSP00000332788Anoctamin-9; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated c [...]
H2AC21 protein networkhttps://string-db.org/network/9606.ENSP00000332790Histone H2A type 2-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
KLHL15 protein networkhttps://string-db.org/network/9606.ENSP00000332791Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PP [...]
KRTAP8-1 protein networkhttps://string-db.org/network/9606.ENSP00000332805Keratin-associated protein 8-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
EMILIN3 protein networkhttps://string-db.org/network/9606.ENSP00000332806EMILIN-3; Elastin microfibril interfacer 3.
PCARE protein networkhttps://string-db.org/network/9606.ENSP00000332809Photoreceptor cilium actin regulator; Plays an essential role for normal photoreceptor cell maintenance and vision.
PTGDR2 protein networkhttps://string-db.org/network/9606.ENSP00000332812Prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)- protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mo [...]
ZNF530 protein networkhttps://string-db.org/network/9606.ENSP00000332861Zinc finger protein 530; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FAM166C protein networkhttps://string-db.org/network/9606.ENSP00000332875Protein FAM166C; Family with sequence similarity 166 member C; Belongs to the FAM166C family.
FLRT2 protein networkhttps://string-db.org/network/9606.ENSP00000332879Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also [...]
FREM3 protein networkhttps://string-db.org/network/9606.ENSP00000332886FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion.
UQCR10 protein networkhttps://string-db.org/network/9606.ENSP00000332887Cytochrome b-c1 complex subunit 9; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which dr [...]
ADGRG3 protein networkhttps://string-db.org/network/9606.ENSP00000332900Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By sim [...]
IZUMO1R protein networkhttps://string-db.org/network/9606.ENSP00000332963Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO [...]
TRIM64B protein networkhttps://string-db.org/network/9606.ENSP00000332969Putative tripartite motif-containing protein 64B; Tripartite motif containing 64B; Belongs to the TRIM/RBCC family.
SMAD3 protein networkhttps://string-db.org/network/9606.ENSP00000332973Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth fac [...]
BACE2 protein networkhttps://string-db.org/network/9606.ENSP00000332979Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release [...]
WBP2NL protein networkhttps://string-db.org/network/9606.ENSP00000332983Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization.
PRSS55 protein networkhttps://string-db.org/network/9606.ENSP00000333003Serine protease 55; Probable serine protease.
SS18L1 protein networkhttps://string-db.org/network/9606.ENSP00000333012Calcium-responsive transactivator; Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to [...]
TTC32 protein networkhttps://string-db.org/network/9606.ENSP00000333018Tetratricopeptide repeat domain 32.
ADSS1 protein networkhttps://string-db.org/network/9606.ENSP00000333019Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes [...]
PHF7 protein networkhttps://string-db.org/network/9606.ENSP00000333024PHD finger protein 7; May play a role in spermatogenesis.
ACTRT3 protein networkhttps://string-db.org/network/9606.ENSP00000333037Actin related protein T3.
C14orf180 protein networkhttps://string-db.org/network/9606.ENSP00000333041Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180.
FIGLA protein networkhttps://string-db.org/network/9606.ENSP00000333097Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-spec [...]
PLA2G6 protein networkhttps://string-db.org/network/9606.ENSP0000033314285/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopre [...]
GH2 protein networkhttps://string-db.org/network/9606.ENSP00000333157Chorionic somatomammotropin hormone 1 isoform 2; Growth hormone 2.
MARCHF11 protein networkhttps://string-db.org/network/9606.ENSP00000333181E3 ubiquitin-protein ligase MARCHF11; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the fo [...]
MBD3L3 protein networkhttps://string-db.org/network/9606.ENSP00000333183methyl-CpG binding domain protein 3 like 3.
OR4F15 protein networkhttps://string-db.org/network/9606.ENSP00000333184Olfactory receptor 4F15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SERPINA5 protein networkhttps://string-db.org/network/9606.ENSP00000333203Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation [...]
CYP2U1 protein networkhttps://string-db.org/network/9606.ENSP00000333212Cytochrome P450 2U1; A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a sub [...]
ZNF470 protein networkhttps://string-db.org/network/9606.ENSP00000333223Zinc finger protein 470; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DEFB108B protein networkhttps://string-db.org/network/9606.ENSP00000333234Beta-defensin 108B; Has antibacterial activity.
INPP5J protein networkhttps://string-db.org/network/9606.ENSP00000333262Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bi [...]
UBA7 protein networkhttps://string-db.org/network/9606.ENSP00000333266Ubiquitin-like modifier-activating enzyme 7; Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine [...]
NR2C1 protein networkhttps://string-db.org/network/9606.ENSP00000333275Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor [...]
H3C13 protein networkhttps://string-db.org/network/9606.ENSP00000333277Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones there [...]
FAAP100 protein networkhttps://string-db.org/network/9606.ENSP00000333283Fanconi anemia core complex-associated protein 100; Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core com [...]
SPNS2 protein networkhttps://string-db.org/network/9606.ENSP00000333292Protein spinster homolog 2; Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function. S1P is a bioactive signaling molecule that regulate [...]
LAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000333298Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
HSD17B13 protein networkhttps://string-db.org/network/9606.ENSP00000333300Hydroxysteroid 17-beta dehydrogenase 13.
SULT1C3 protein networkhttps://string-db.org/network/9606.ENSP00000333310Sulfotransferase 1C3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups [...]
TUBA8 protein networkhttps://string-db.org/network/9606.ENSP00000333326Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...]
USP17L2 protein networkhttps://string-db.org/network/9606.ENSP00000333329Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation b [...]
JRKL protein networkhttps://string-db.org/network/9606.ENSP00000333350Jerky protein homolog-like; JRK like; Belongs to the tigger transposable element derived protein family.
RNASE10 protein networkhttps://string-db.org/network/9606.ENSP00000333358Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pe [...]
DNAH8 protein networkhttps://string-db.org/network/9606.ENSP00000333363Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
CCDC60 protein networkhttps://string-db.org/network/9606.ENSP00000333374Coiled-coil domain containing 60.
USP45 protein networkhttps://string-db.org/network/9606.ENSP00000333376Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function.
ARSI protein networkhttps://string-db.org/network/9606.ENSP00000333395Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is [...]
MRPL40 protein networkhttps://string-db.org/network/9606.ENSP00000333401Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family.
SKA2 protein networkhttps://string-db.org/network/9606.ENSP00000333433Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Require [...]
TREX2 protein networkhttps://string-db.org/network/9606.ENSP00000333441Three prime repair exonuclease 2; Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair.
MAGEA2B protein networkhttps://string-db.org/network/9606.ENSP00000333487Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiqui [...]
URAD protein networkhttps://string-db.org/network/9606.ENSP00000333490Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; Catalyzes the stereoselective decarboxylation of 2-oxo-4- hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
KCND2 protein networkhttps://string-db.org/network/9606.ENSP00000333496Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the [...]
SLC24A3 protein networkhttps://string-db.org/network/9606.ENSP00000333519Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
CYP2F1 protein networkhttps://string-db.org/network/9606.ENSP00000333534Cytochrome P450 2F1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses [...]
MIPOL1 protein networkhttps://string-db.org/network/9606.ENSP00000333539Mirror-image polydactyly 1.
RAB11B protein networkhttps://string-db.org/network/9606.ENSP00000333547Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle be [...]
PLPBP protein networkhttps://string-db.org/network/9606.ENSP00000333551Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active f [...]
SLC35D3 protein networkhttps://string-db.org/network/9606.ENSP00000333591Solute carrier family 35 member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules; Belongs to the TPT transporter family. SLC35D subfamily.
NXPH4 protein networkhttps://string-db.org/network/9606.ENSP00000333593Neurexophilin-4; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.
MTA1 protein networkhttps://string-db.org/network/9606.ENSP00000333633Metastasis-associated protein MTA1; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone- deacetylase multiprotein complex (Nu [...]
IFNL2 protein networkhttps://string-db.org/network/9606.ENSP00000333639Interferon lambda-2; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...]
EYA2 protein networkhttps://string-db.org/network/9606.ENSP00000333640Eyes absent homolog 2; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Ty [...]
MX2 protein networkhttps://string-db.org/network/9606.ENSP00000333657Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral [...]
ZNF571 protein networkhttps://string-db.org/network/9606.ENSP00000333660Zinc finger protein 571; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ACAA1 protein networkhttps://string-db.org/network/9606.ENSP000003336643-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.
ADI1 protein networkhttps://string-db.org/network/9606.ENSP000003336661,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also d [...]
SHMT2 protein networkhttps://string-db.org/network/9606.ENSP00000333667Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine [...]
NFAM1 protein networkhttps://string-db.org/network/9606.ENSP00000333680NFAT activation molecule 1; May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcript [...]
MAPK11 protein networkhttps://string-db.org/network/9606.ENSP00000333685Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an [...]
TMEM179B protein networkhttps://string-db.org/network/9606.ENSP00000333697Transmembrane protein 179B; Belongs to the TMEM179 family.
OR6X1 protein networkhttps://string-db.org/network/9606.ENSP00000333724Olfactory receptor 6X1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF26 protein networkhttps://string-db.org/network/9606.ENSP00000333725Zinc finger protein 26; May be involved in transcriptional regulation.
NPAP1 protein networkhttps://string-db.org/network/9606.ENSP00000333735Nuclear pore-associated protein 1; May be involved in spermatogenesis.
BSG protein networkhttps://string-db.org/network/9606.ENSP00000333769Basigin; Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane. Plays pivotal roles in spermatogenesis, emb [...]
ZNF479 protein networkhttps://string-db.org/network/9606.ENSP00000333776Zinc finger protein 479; May be involved in transcriptional regulation.
EVI2B protein networkhttps://string-db.org/network/9606.ENSP00000333779Protein EVI2B; Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor [...]
MRGPRX2 protein networkhttps://string-db.org/network/9606.ENSP00000333800Mas-related G-protein coupled receptor member X2; Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a bas [...]
ZNF599 protein networkhttps://string-db.org/network/9606.ENSP00000333802Zinc finger protein 599; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ALG12 protein networkhttps://string-db.org/network/9606.ENSP00000333813Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2) [...]
MC2R protein networkhttps://string-db.org/network/9606.ENSP00000333821Adrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). Belongs to the G-protein coupled r [...]
CMTM4 protein networkhttps://string-db.org/network/9606.ENSP00000333833CKLF-like MARVEL transmembrane domain-containing protein 4; Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune toler [...]
FIGN protein networkhttps://string-db.org/network/9606.ENSP00000333836Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule [...]
MRPL12 protein networkhttps://string-db.org/network/9606.ENSP0000033383739S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family.
C11orf88 protein networkhttps://string-db.org/network/9606.ENSP00000333845UPF0722 protein C11orf88.
KRTAP22-1 protein networkhttps://string-db.org/network/9606.ENSP00000333887Keratin-associated protein 22-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
RPS6KA4 protein networkhttps://string-db.org/network/9606.ENSP00000333896Ribosomal protein S6 kinase alpha-4; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the reg [...]
OIT3 protein networkhttps://string-db.org/network/9606.ENSP00000333900Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development.
CFAP73 protein networkhttps://string-db.org/network/9606.ENSP00000333915Cilia- and flagella-associated protein 73; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Belongs to the CFAP73 family.
DUSP18 protein networkhttps://string-db.org/network/9606.ENSP00000333917Dual specificity protein phosphatase 18; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphoth [...]
BTLA protein networkhttps://string-db.org/network/9606.ENSP00000333919B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or [...]
TTF1 protein networkhttps://string-db.org/network/9606.ENSP00000333920Transcription termination factor 1; Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription o [...]
ABCC5 protein networkhttps://string-db.org/network/9606.ENSP00000333926Multidrug resistance-associated protein 5; Acts as a multispecific organic anion pump which can transport nucleotide analogs; Belongs to the ABC transporter superfamily. ABCC family. Conjugate tr [...]
TRMT11 protein networkhttps://string-db.org/network/9606.ENSP00000333934tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide [...]
NEXN protein networkhttps://string-db.org/network/9606.ENSP00000333938Nexilin; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
KIF9 protein networkhttps://string-db.org/network/9606.ENSP00000333942Kinesin-like protein KIF9; Kinesin family member 9.
COQ6 protein networkhttps://string-db.org/network/9606.ENSP00000333946Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexa [...]
CHST15 protein networkhttps://string-db.org/network/9606.ENSP00000333947Carbohydrate sulfotransferase 15; Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroit [...]
RPS19BP1 protein networkhttps://string-db.org/network/9606.ENSP00000333948Active regulator of SIRT1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. Belongs [...]
LCE5A protein networkhttps://string-db.org/network/9606.ENSP00000333952Late cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
SELENOV protein networkhttps://string-db.org/network/9606.ENSP00000333956Selenoprotein V; May be involved in a redox-related process.
ZNF749 protein networkhttps://string-db.org/network/9606.ENSP00000333980Zinc finger protein 749; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NDEL1 protein networkhttps://string-db.org/network/9606.ENSP00000333982Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least i [...]
TRDN protein networkhttps://string-db.org/network/9606.ENSP00000333984Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contractio [...]
KRTAP17-1 protein networkhttps://string-db.org/network/9606.ENSP00000333993Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
HAP1 protein networkhttps://string-db.org/network/9606.ENSP00000334002Huntingtin-associated protein 1; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within [...]
INTU protein networkhttps://string-db.org/network/9606.ENSP00000334003Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of [...]
PARVA protein networkhttps://string-db.org/network/9606.ENSP00000334008Alpha-parvin; Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the [...]
EMC10 protein networkhttps://string-db.org/network/9606.ENSP00000334037ER membrane protein complex subunit 10; Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activ [...]
RSBN1L protein networkhttps://string-db.org/network/9606.ENSP00000334040Lysine-specific demethylase RSBN1L; Lysine-specific demethylase that specifically demethylates methylated lysine residues of proteins; Belongs to the round spermatid basic protein 1 family.
TAC4 protein networkhttps://string-db.org/network/9606.ENSP00000334042Endokinin-A/B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscl [...]
UBL4B protein networkhttps://string-db.org/network/9606.ENSP00000334044Ubiquitin-like protein 4B; Ubiquitin like 4B.
TAS2R42 protein networkhttps://string-db.org/network/9606.ENSP00000334050Taste receptor type 2 member 42; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
GNAL protein networkhttps://string-db.org/network/9606.ENSP00000334051Guanine nucleotide-binding protein G(olf) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(o [...]
OR13C8 protein networkhttps://string-db.org/network/9606.ENSP00000334068Olfactory receptor 13C8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMEM212 protein networkhttps://string-db.org/network/9606.ENSP00000334072Transmembrane protein 212.
EXOC7 protein networkhttps://string-db.org/network/9606.ENSP00000334100Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeti [...]
DHRSX protein networkhttps://string-db.org/network/9606.ENSP00000334113Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation-induced autophagy ; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
OR10T2 protein networkhttps://string-db.org/network/9606.ENSP00000334115Olfactory receptor 10T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FGF3 protein networkhttps://string-db.org/network/9606.ENSP00000334122Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the h [...]
CYP27C1 protein networkhttps://string-db.org/network/9606.ENSP00000334128Cytochrome P450 27C1; Catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4-didehydroretinol (also called vitamin A2, the precursor of 11- [...]
RGS9BP protein networkhttps://string-db.org/network/9606.ENSP00000334134Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via it [...]
KLHDC10 protein networkhttps://string-db.org/network/9606.ENSP00000334140Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5.
F3 protein networkhttps://string-db.org/network/9606.ENSP00000334145Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a ro [...]
WDR25 protein networkhttps://string-db.org/network/9606.ENSP00000334148WD repeat domain 25.
RFTN1 protein networkhttps://string-db.org/network/9606.ENSP00000334153Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic c [...]
KDM4D protein networkhttps://string-db.org/network/9606.ENSP00000334181Lysine-specific demethylase 4D; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', [...]
VWCE protein networkhttps://string-db.org/network/9606.ENSP00000334186Von Willebrand factor C and EGF domain-containing protein; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
LCE1F protein networkhttps://string-db.org/network/9606.ENSP00000334187Late cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum.
KRTAP10-11 protein networkhttps://string-db.org/network/9606.ENSP00000334197Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), whic [...]
CACNA1H protein networkhttps://string-db.org/network/9606.ENSP00000334198Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activat [...]
ATP4B protein networkhttps://string-db.org/network/9606.ENSP00000334216Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial [...]
SLC36A2 protein networkhttps://string-db.org/network/9606.ENSP00000334223Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine [...]
CYP4Z1 protein networkhttps://string-db.org/network/9606.ENSP00000334246Cytochrome P450 family 4 subfamily Z member 1.
C5orf38 protein networkhttps://string-db.org/network/9606.ENSP00000334267Protein CEI; Chromosome 5 open reading frame 38.
UGT2B28 protein networkhttps://string-db.org/network/9606.ENSP00000334276UDP-glucuronosyltransferase 2B28; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuron [...]
KRTAP21-2 protein networkhttps://string-db.org/network/9606.ENSP00000334287Keratin-associated protein 21-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
C9orf85 protein networkhttps://string-db.org/network/9606.ENSP00000334289Uncharacterized protein C9orf85; Chromosome 9 open reading frame 85.
TCFL5 protein networkhttps://string-db.org/network/9606.ENSP00000334294Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.
ACTL7A protein networkhttps://string-db.org/network/9606.ENSP00000334300Actin-like protein 7A; Actin like 7A; Belongs to the actin family.
SYNE3 protein networkhttps://string-db.org/network/9606.ENSP00000334308Nesprin-3; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interac [...]
EML1 protein networkhttps://string-db.org/network/9606.ENSP00000334314Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic s [...]
PCLO protein networkhttps://string-db.org/network/9606.ENSP00000334319Protein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (By similarity). After synthesis, par [...]
UNC5B protein networkhttps://string-db.org/network/9606.ENSP00000334329Netrin receptor UNC5B; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in gro [...]
DEFB105A protein networkhttps://string-db.org/network/9606.ENSP00000334330Beta-defensin 105; Has antibacterial activity.
DEFB106B protein networkhttps://string-db.org/network/9606.ENSP00000334364Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2. Belongs to the beta-defensin family.
KPNA4 protein networkhttps://string-db.org/network/9606.ENSP00000334373Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...]
SLITRK2 protein networkhttps://string-db.org/network/9606.ENSP00000334374SLIT and NTRK-like protein 2; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Suppresses neurite outgrowth (By similarity).
C2CD3 protein networkhttps://string-db.org/network/9606.ENSP00000334379C2 domain-containing protein 3; Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal [...]
HOMER1 protein networkhttps://string-db.org/network/9606.ENSP00000334382Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...]
OR4F5 protein networkhttps://string-db.org/network/9606.ENSP00000334393Olfactory receptor 4F5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PRAMEF14 protein networkhttps://string-db.org/network/9606.ENSP00000334410PRAME family member 14.
FAM183A protein networkhttps://string-db.org/network/9606.ENSP00000334415Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family.
OR4C12 protein networkhttps://string-db.org/network/9606.ENSP00000334418Olfactory receptor 4C12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FAM9C protein networkhttps://string-db.org/network/9606.ENSP00000334430Protein FAM9C; Family with sequence similarity 9 member C.
NUDT17 protein networkhttps://string-db.org/network/9606.ENSP00000334437Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family.
OR10J5 protein networkhttps://string-db.org/network/9606.ENSP00000334441Olfactory receptor 10J5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GNG2 protein networkhttps://string-db.org/network/9606.ENSP00000334448Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
OR13F1 protein networkhttps://string-db.org/network/9606.ENSP00000334452Olfactory receptor 13F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5D14 protein networkhttps://string-db.org/network/9606.ENSP00000334456Olfactory receptor 5D14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LYPD6 protein networkhttps://string-db.org/network/9606.ENSP00000334463Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a p [...]
FOXE3 protein networkhttps://string-db.org/network/9606.ENSP00000334472Forkhead box protein E3; Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle. During lens development, controls the ratio [...]
ZMIZ1 protein networkhttps://string-db.org/network/9606.ENSP00000334474Zinc finger MIZ domain-containing protein 1; Acts as transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR act [...]
DMRTC1B protein networkhttps://string-db.org/network/9606.ENSP00000334501Doublesex- and mab-3-related transcription factor C1; DMRT like family C1B; Belongs to the DMRT family.
SREK1 protein networkhttps://string-db.org/network/9606.ENSP00000334538Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SF [...]
TAL2 protein networkhttps://string-db.org/network/9606.ENSP00000334547T-cell acute lymphocytic leukemia protein 2; TAL bHLH transcription factor 2.
KRTAP6-2 protein networkhttps://string-db.org/network/9606.ENSP00000334560Keratin-associated protein 6-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
POLR3C protein networkhttps://string-db.org/network/9606.ENSP00000334564DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core com [...]
CYP2R1 protein networkhttps://string-db.org/network/9606.ENSP00000334592Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3).
TMPRSS11A protein networkhttps://string-db.org/network/9606.ENSP00000334611Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
PDZD8 protein networkhttps://string-db.org/network/9606.ENSP00000334642PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering [...]
LCE3C protein networkhttps://string-db.org/network/9606.ENSP00000334644Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicro [...]
KCNK18 protein networkhttps://string-db.org/network/9606.ENSP00000334650Potassium channel subfamily K member 18; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets [...]
TRIM46 protein networkhttps://string-db.org/network/9606.ENSP00000334657Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for [...]
FSCN2 protein networkhttps://string-db.org/network/9606.ENSP00000334665Fascin-2; Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
ERCC6L protein networkhttps://string-db.org/network/9606.ENSP00000334675DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetocho [...]
DEFB107A protein networkhttps://string-db.org/network/9606.ENSP00000334681Beta-defensin 107; Has antibacterial activity.
ZNF568 protein networkhttps://string-db.org/network/9606.ENSP00000334685Zinc finger protein 568; Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. E [...]
KRTAP19-7 protein networkhttps://string-db.org/network/9606.ENSP00000334696Keratin-associated protein 19-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
IGFN1 protein networkhttps://string-db.org/network/9606.ENSP00000334714Immunoglobulin like and fibronectin type III domain containing 1.
CCDC84 protein networkhttps://string-db.org/network/9606.ENSP00000334767Coiled-coil domain-containing protein 84.
TESC protein networkhttps://string-db.org/network/9606.ENSP00000334785Calcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, c [...]
KRT26 protein networkhttps://string-db.org/network/9606.ENSP00000334798Keratin, type I cytoskeletal 26; Keratin 26.
DHRS4L2 protein networkhttps://string-db.org/network/9606.ENSP00000334801Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase.
H1-7 protein networkhttps://string-db.org/network/9606.ENSP00000334805Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Inv [...]
USP16 protein networkhttps://string-db.org/network/9606.ENSP00000334808Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactiva [...]
RAX protein networkhttps://string-db.org/network/9606.ENSP00000334813Retinal homeobox protein Rx; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor cons [...]
KRTAP13-4 protein networkhttps://string-db.org/network/9606.ENSP00000334834Keratin-associated protein 13-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
BMP2K protein networkhttps://string-db.org/network/9606.ENSP00000334836BMP-2-inducible protein kinase; May be involved in osteoblast differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
TMEM216 protein networkhttps://string-db.org/network/9606.ENSP00000334844Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.
TMEM104 protein networkhttps://string-db.org/network/9606.ENSP00000334849Transmembrane protein 104; Belongs to the TMEM104 family.
RGS7BP protein networkhttps://string-db.org/network/9606.ENSP00000334851Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellula [...]
ZNF555 protein networkhttps://string-db.org/network/9606.ENSP00000334853Zinc finger protein 555; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZACN protein networkhttps://string-db.org/network/9606.ENSP00000334854Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel.
KRTAP15-1 protein networkhttps://string-db.org/network/9606.ENSP00000334866Keratin-associated protein 15-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
LCE1A protein networkhttps://string-db.org/network/9606.ENSP00000334869Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum.
MT1F protein networkhttps://string-db.org/network/9606.ENSP00000334872Metallothionein-1F; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
GRK1 protein networkhttps://string-db.org/network/9606.ENSP00000334876Rhodopsin kinase GRK1; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. [...]
SOWAHB protein networkhttps://string-db.org/network/9606.ENSP00000334879Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family.
PDE2A protein networkhttps://string-db.org/network/9606.ENSP00000334910cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important phys [...]
KRTAP9-4 protein networkhttps://string-db.org/network/9606.ENSP00000334922Keratin-associated protein 9-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
PTPRB protein networkhttps://string-db.org/network/9606.ENSP00000334928Receptor-type tyrosine-protein phosphatase beta; Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential fo [...]
OR9Q1 protein networkhttps://string-db.org/network/9606.ENSP00000334934Olfactory receptor 9Q1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
UPK3B protein networkhttps://string-db.org/network/9606.ENSP00000334938Putative postmeiotic segregation increased 2-like protein 11; Uroplakin 3B.
GGN protein networkhttps://string-db.org/network/9606.ENSP00000334940Gametogenetin; May be involved in spermatogenesis.
PTPRU protein networkhttps://string-db.org/network/9606.ENSP00000334941Receptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proli [...]
ADGRA3 protein networkhttps://string-db.org/network/9606.ENSP00000334952Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled recept [...]
CARMIL2 protein networkhttps://string-db.org/network/9606.ENSP00000334958Capping protein, Arp2/3 and myosin-I linker protein 2; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filamen [...]
C3orf70 protein networkhttps://string-db.org/network/9606.ENSP00000334974UPF0524 protein C3orf70; May play a role in neuronal and neurobehavioral development.
KRTAP19-5 protein networkhttps://string-db.org/network/9606.ENSP00000334985Keratin-associated protein 19-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
CCIN protein networkhttps://string-db.org/network/9606.ENSP00000334996Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation.
MT1B protein networkhttps://string-db.org/network/9606.ENSP00000334998Metallothionein-1B; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
LCE3A protein networkhttps://string-db.org/network/9606.ENSP00000335006Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicro [...]
SPIN2B protein networkhttps://string-db.org/network/9606.ENSP00000335008Spindlin-2B; Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Exhibits H3K4me3-bind [...]
PRR30 protein networkhttps://string-db.org/network/9606.ENSP00000335017Proline-rich protein 30; Proline rich 30.
SERPINA11 protein networkhttps://string-db.org/network/9606.ENSP00000335024Serpin family A member 11.
OR5D18 protein networkhttps://string-db.org/network/9606.ENSP00000335025Olfactory receptor 5D18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RASA3 protein networkhttps://string-db.org/network/9606.ENSP00000335029Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
VSTM2B protein networkhttps://string-db.org/network/9606.ENSP00000335038V-set and transmembrane domain containing 2B.
NIBAN3 protein networkhttps://string-db.org/network/9606.ENSP00000335040Niban apoptosis regulator 3; Belongs to the Niban family.
ZNF486 protein networkhttps://string-db.org/network/9606.ENSP00000335042Zinc finger protein 486; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ARID2 protein networkhttps://string-db.org/network/9606.ENSP00000335044AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required fo [...]
WASF3 protein networkhttps://string-db.org/network/9606.ENSP00000335055Wiskott-Aldrich syndrome protein family member 3; Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...]
HPDL protein networkhttps://string-db.org/network/9606.ENSP000003350604-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity; Belongs to the 4HPPD family.
PDCD1 protein networkhttps://string-db.org/network/9606.ENSP00000335062Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals [...]
GHRL protein networkhttps://string-db.org/network/9606.ENSP00000335074Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating ef [...]
EDARADD protein networkhttps://string-db.org/network/9606.ENSP00000335076Ectodysplasin-A receptor-associated adapter protein; Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal org [...]
FAM91A1 protein networkhttps://string-db.org/network/9606.ENSP00000335082Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1.
ZNRF1 protein networkhttps://string-db.org/network/9606.ENSP00000335091E3 ubiquitin-protein ligase ZNRF1; E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the estab [...]
TMEM17 protein networkhttps://string-db.org/network/9606.ENSP00000335094Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of tran [...]
ANKRD37 protein networkhttps://string-db.org/network/9606.ENSP00000335147Ankyrin repeat domain 37.
HSP90AA1 protein networkhttps://string-db.org/network/9606.ENSP00000335153Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle con [...]
ADGRD2 protein networkhttps://string-db.org/network/9606.ENSP00000335156Adhesion G-protein coupled receptor D2; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
GPR142 protein networkhttps://string-db.org/network/9606.ENSP00000335158Probable G-protein coupled receptor 142; Orphan receptor.
TBX10 protein networkhttps://string-db.org/network/9606.ENSP00000335191T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes.
VPS39 protein networkhttps://string-db.org/network/9606.ENSP00000335193Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this woul [...]
GLDN protein networkhttps://string-db.org/network/9606.ENSP00000335196Gliomedin shedded ectodomain; Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between S [...]
BCDIN3D protein networkhttps://string-db.org/network/9606.ENSP00000335201RNA 5'-monophosphate methyltransferase; O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also met [...]
ATP5IF1 protein networkhttps://string-db.org/network/9606.ENSP00000335203ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts [...]
ENTPD5 protein networkhttps://string-db.org/network/9606.ENSP00000335246Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation a [...]
STARD10 protein networkhttps://string-db.org/network/9606.ENSP00000335247START domain-containing protein 10; May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containi [...]
ANGPTL5 protein networkhttps://string-db.org/network/9606.ENSP00000335255Angiopoietin-related protein 5; Angiopoietin like 5.
TMLHE protein networkhttps://string-db.org/network/9606.ENSP00000335261Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
DEFB105B protein networkhttps://string-db.org/network/9606.ENSP00000335281Defensin beta 105B.
C1QL4 protein networkhttps://string-db.org/network/9606.ENSP00000335285Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte d [...]
SLC51B protein networkhttps://string-db.org/network/9606.ENSP00000335292Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export [...]
DLST protein networkhttps://string-db.org/network/9606.ENSP000003353042-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex. The 2-oxoglutar [...]
DPPA4 protein networkhttps://string-db.org/network/9606.ENSP00000335306Developmental pluripotency-associated protein 4; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ec [...]
DEFB106A protein networkhttps://string-db.org/network/9606.ENSP00000335307Defensin beta 106A.
BCL9L protein networkhttps://string-db.org/network/9606.ENSP00000335320B-cell CLL/lymphoma 9-like protein; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic tra [...]
SF3B1 protein networkhttps://string-db.org/network/9606.ENSP00000335321Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...]
CCDC73 protein networkhttps://string-db.org/network/9606.ENSP00000335325Coiled-coil domain containing 73.
CDKN3 protein networkhttps://string-db.org/network/9606.ENSP00000335357Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. D [...]
LCE3B protein networkhttps://string-db.org/network/9606.ENSP00000335358Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicro [...]
TRAPPC11 protein networkhttps://string-db.org/network/9606.ENSP00000335371Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
DEFB128 protein networkhttps://string-db.org/network/9606.ENSP00000335382Beta-defensin 128; Has antibacterial activity; Belongs to the beta-defensin family.
ZPBP2 protein networkhttps://string-db.org/network/9606.ENSP00000335384Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization.
SPATA12 protein networkhttps://string-db.org/network/9606.ENSP00000335392Spermatogenesis-associated protein 12; Spermatogenesis associated 12.
RTN4RL2 protein networkhttps://string-db.org/network/9606.ENSP00000335397Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant [...]
ZNF20 protein networkhttps://string-db.org/network/9606.ENSP00000335437Zinc finger protein 20; May be involved in transcriptional regulation.
NME9 protein networkhttps://string-db.org/network/9606.ENSP00000335444Thioredoxin domain-containing protein 6; May be a regulator of microtubule physiology; Belongs to the NDK family.
KNL1 protein networkhttps://string-db.org/network/9606.ENSP00000335463Kinetochore scaffold 1; Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of t [...]
EMID1 protein networkhttps://string-db.org/network/9606.ENSP00000335481EMI domain containing 1.
FOXD2 protein networkhttps://string-db.org/network/9606.ENSP00000335493Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis.
C7orf57 protein networkhttps://string-db.org/network/9606.ENSP00000335500Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57.
KRTAP20-1 protein networkhttps://string-db.org/network/9606.ENSP00000335503Keratin-associated protein 20-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
DEFB131A protein networkhttps://string-db.org/network/9606.ENSP00000335538Beta-defensin 131A; Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion ; Belongs to the beta-defensin famil [...]
SLX4IP protein networkhttps://string-db.org/network/9606.ENSP00000335557SLX4 interacting protein.
ARHGEF25 protein networkhttps://string-db.org/network/9606.ENSP00000335560Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a g [...]
KRTAP10-8 protein networkhttps://string-db.org/network/9606.ENSP00000335565Keratin-associated protein 10-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP21-1 protein networkhttps://string-db.org/network/9606.ENSP00000335566Keratin-associated protein 21-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP19-4 protein networkhttps://string-db.org/network/9606.ENSP00000335567Keratin-associated protein 19-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
OR1J2 protein networkhttps://string-db.org/network/9606.ENSP00000335575Olfactory receptor 1J2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ARGFX protein networkhttps://string-db.org/network/9606.ENSP00000335578Arginine-fifty homeobox; Putative transcription factor.
TCP11L1 protein networkhttps://string-db.org/network/9606.ENSP00000335595T-complex protein 11-like protein 1; T-complex 11 like 1.
CMTM7 protein networkhttps://string-db.org/network/9606.ENSP00000335605CKLF like MARVEL transmembrane domain containing 7.
SPATA21 protein networkhttps://string-db.org/network/9606.ENSP00000335612Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids.
PPFIA3 protein networkhttps://string-db.org/network/9606.ENSP00000335614Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...]
BTBD7 protein networkhttps://string-db.org/network/9606.ENSP00000335615BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, [...]
GSTA1 protein networkhttps://string-db.org/network/9606.ENSP00000335620Glutathione S-transferase A1, N-terminally processed; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide rang [...]
VSIG10L protein networkhttps://string-db.org/network/9606.ENSP00000335623V-set and immunoglobulin domain containing 10 like.
SPDYA protein networkhttps://string-db.org/network/9606.ENSP00000335628Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing [...]
CHP1 protein networkhttps://string-db.org/network/9606.ENSP00000335632Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcriptio [...]
NAA20 protein networkhttps://string-db.org/network/9606.ENSP00000335636N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met- [...]
FSD2 protein networkhttps://string-db.org/network/9606.ENSP00000335651Fibronectin type III and SPRY domain containing 2.
FMNL3 protein networkhttps://string-db.org/network/9606.ENSP00000335655Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesi [...]
KRTAP19-2 protein networkhttps://string-db.org/network/9606.ENSP00000335660Keratin-associated protein 19-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
PRELID2 protein networkhttps://string-db.org/network/9606.ENSP00000335675PRELI domain containing 2.
FOXK2 protein networkhttps://string-db.org/network/9606.ENSP00000335677Forkhead box protein K2; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy (By similarity). Recognizes and binds the forkhead [...]
PSME3IP1 protein networkhttps://string-db.org/network/9606.ENSP00000335808PSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of so [...]
TTC7B protein networkhttps://string-db.org/network/9606.ENSP00000336127Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinosit [...]
CEP63 protein networkhttps://string-db.org/network/9606.ENSP00000336524Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and [...]
NR1I2 protein networkhttps://string-db.org/network/9606.ENSP00000336528Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcriptio [...]
CLDN2 protein networkhttps://string-db.org/network/9606.ENSP00000336571Claudin-2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
CDR2L protein networkhttps://string-db.org/network/9606.ENSP00000336587Cerebellar degeneration related protein 2 like.
RAD54B protein networkhttps://string-db.org/network/9606.ENSP00000336606DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epista [...]
STRADA protein networkhttps://string-db.org/network/9606.ENSP00000336655STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation ty [...]
LRRC71 protein networkhttps://string-db.org/network/9606.ENSP00000336661Leucine-rich repeat-containing protein 71; Leucine rich repeat containing 71.
AP1S1 protein networkhttps://string-db.org/network/9606.ENSP00000336666AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP c [...]
CBX3 protein networkhttps://string-db.org/network/9606.ENSP00000336687Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigeneti [...]
ABHD12B protein networkhttps://string-db.org/network/9606.ENSP00000336693Protein ABHD12B; Abhydrolase domain containing 12B; Belongs to the serine esterase family.
RAD51C protein networkhttps://string-db.org/network/9606.ENSP00000336701DNA repair protein RAD51 homolog 3; Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA bre [...]
EIF5A protein networkhttps://string-db.org/network/9606.ENSP00000336702Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of deca [...]
TNPO1 protein networkhttps://string-db.org/network/9606.ENSP00000336712Transportin-1; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of t [...]
LARP1 protein networkhttps://string-db.org/network/9606.ENSP00000336721La-related protein 1; RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. [...]
TBC1D22A protein networkhttps://string-db.org/network/9606.ENSP00000336724TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s).
GALNT16 protein networkhttps://string-db.org/network/9606.ENSP00000336729Polypeptide N-acetylgalactosaminyltransferase 16; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
ST6GALNAC4 protein networkhttps://string-db.org/network/9606.ENSP00000336733N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D); Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc res [...]
LIMK1 protein networkhttps://string-db.org/network/9606.ENSP00000336740LIM domain kinase 1; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pa [...]
DHX15 protein networkhttps://string-db.org/network/9606.ENSP00000336741Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to [...]
HIP1 protein networkhttps://string-db.org/network/9606.ENSP00000336747Huntingtin-interacting protein 1; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependen [...]
SUPT7L protein networkhttps://string-db.org/network/9606.ENSP00000336750SPT7 like, STAGA complex subunit gamma.
FIP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000336752Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA [...]
ANG protein networkhttps://string-db.org/network/9606.ENSP00000336762Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing [...]
KIR2DL1 protein networkhttps://string-db.org/network/9606.ENSP00000336769Killer cell immunoglobulin-like receptor 2DL1; Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis; Belong [...]
SYNM protein networkhttps://string-db.org/network/9606.ENSP00000336775Synemin; Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its i [...]
TNRC6C protein networkhttps://string-db.org/network/9606.ENSP00000336783Trinucleotide repeat-containing gene 6C protein; Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs b [...]
ATF4 protein networkhttps://string-db.org/network/9606.ENSP00000336790Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular [...]
TUBA1B protein networkhttps://string-db.org/network/9606.ENSP00000336799Detyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site [...]
KLHL25 protein networkhttps://string-db.org/network/9606.ENSP00000336800Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by med [...]
LUZP2 protein networkhttps://string-db.org/network/9606.ENSP00000336817Leucine zipper protein 2.
FGG protein networkhttps://string-db.org/network/9606.ENSP00000336829Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary co [...]
PLS1 protein networkhttps://string-db.org/network/9606.ENSP00000336831Plastin-1; Actin-bundling protein in the absence of calcium.
ACTR8 protein networkhttps://string-db.org/network/9606.ENSP00000336842Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. [...]
IQCH protein networkhttps://string-db.org/network/9606.ENSP00000336861IQ domain-containing protein H; May play a regulatory role in spermatogenesis.
RBBP9 protein networkhttps://string-db.org/network/9606.ENSP00000336866Serine hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. M [...]
CENPA protein networkhttps://string-db.org/network/9606.ENSP00000336868Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric ch [...]
SLC39A9 protein networkhttps://string-db.org/network/9606.ENSP00000336887Zinc transporter ZIP9; May act as a zinc-influx transporter.
NAB1 protein networkhttps://string-db.org/network/9606.ENSP00000336894NGFI-A-binding protein 1; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2.
FGD3 protein networkhttps://string-db.org/network/9606.ENSP00000336914FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for fre [...]
ARHGAP10 protein networkhttps://string-db.org/network/9606.ENSP00000336923Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organizat [...]
PNRC1 protein networkhttps://string-db.org/network/9606.ENSP00000336931Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction.
CLPTM1 protein networkhttps://string-db.org/network/9606.ENSP00000336994Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family.
HJV protein networkhttps://string-db.org/network/9606.ENSP00000337014Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. Belongs to the repuls [...]
UNC119 protein networkhttps://string-db.org/network/9606.ENSP00000337040Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacte [...]
SEL1L protein networkhttps://string-db.org/network/9606.ENSP00000337053Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfol [...]
NME1 protein networkhttps://string-db.org/network/9606.ENSP00000337060Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...]
CXCL14 protein networkhttps://string-db.org/network/9606.ENSP00000337065C-X-C motif chemokine 14; Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not i [...]
ZNF112 protein networkhttps://string-db.org/network/9606.ENSP00000337081Zinc finger protein 112; May be involved in transcriptional regulation.
MEN1 protein networkhttps://string-db.org/network/9606.ENSP00000337088Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Bi [...]
CHAT protein networkhttps://string-db.org/network/9606.ENSP00000337103Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. Belongs to the carnitine/choline acetyltransferase fami [...]
ZNF354A protein networkhttps://string-db.org/network/9606.ENSP00000337122Zinc finger protein 354A; Belongs to the krueppel C2H2-type zinc-finger protein family.
EDN3 protein networkhttps://string-db.org/network/9606.ENSP00000337128Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides.
SERPINA9 protein networkhttps://string-db.org/network/9606.ENSP00000337133Serpin A9; Protease inhibitor that inhibits trypsin and trypsin-like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro).
ENOX2 protein networkhttps://string-db.org/network/9606.ENSP00000337146Protein disulfide-thiol oxidoreductase; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at t [...]
EPB41L1 protein networkhttps://string-db.org/network/9606.ENSP00000337168Band 4.1-like protein 1; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channel [...]
AZIN1 protein networkhttps://string-db.org/network/9606.ENSP00000337180Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that cou [...]
PRPF4B protein networkhttps://string-db.org/network/9606.ENSP00000337194Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
LRAT protein networkhttps://string-db.org/network/9606.ENSP00000337224Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms [...]
CDCA4 protein networkhttps://string-db.org/network/9606.ENSP00000337226Cell division cycle-associated protein 4; May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells a [...]
ARHGEF1 protein networkhttps://string-db.org/network/9606.ENSP00000337261Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activa [...]
CENPQ protein networkhttps://string-db.org/network/9606.ENSP00000337289Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
SIRT6 protein networkhttps://string-db.org/network/9606.ENSP00000337332NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chrom [...]
SLC22A8 protein networkhttps://string-db.org/network/9606.ENSP00000337335Solute carrier family 22 member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transp [...]
TDP1 protein networkhttps://string-db.org/network/9606.ENSP00000337353Tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phospha [...]
LIPA protein networkhttps://string-db.org/network/9606.ENSP00000337354Lysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis [...]
HDHD5 protein networkhttps://string-db.org/network/9606.ENSP00000337358Haloacid dehalogenase like hydrolase domain containing 5.
ZNF224 protein networkhttps://string-db.org/network/9606.ENSP00000337368Zinc finger protein 224; May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing [...]
NLRP3 protein networkhttps://string-db.org/network/9606.ENSP00000337383NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...]
ZFP36L1 protein networkhttps://string-db.org/network/9606.ENSP00000337386mRNA decay activator protein ZFP36L1; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail remov [...]
UXT protein networkhttps://string-db.org/network/9606.ENSP00000337393Protein UXT; Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chro [...]
HYAL3 protein networkhttps://string-db.org/network/9606.ENSP00000337425Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Invol [...]
IL17F protein networkhttps://string-db.org/network/9606.ENSP00000337432Interleukin-17F; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the product [...]
DACT1 protein networkhttps://string-db.org/network/9606.ENSP00000337439Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways throu [...]
NXN protein networkhttps://string-db.org/network/9606.ENSP00000337443Nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a tra [...]
ELAC2 protein networkhttps://string-db.org/network/9606.ENSP00000337445Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3'- processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from p [...]
STARD3 protein networkhttps://string-db.org/network/9606.ENSP00000337446StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticul [...]
CYP3A7 protein networkhttps://string-db.org/network/9606.ENSP00000337450Cytochrome P450 3A7; A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins during embryogenesis. Mechanistically, uses molecular oxygen inserting one oxygen [...]
EPHA3 protein networkhttps://string-db.org/network/9606.ENSP00000337451Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
NIPA1 protein networkhttps://string-db.org/network/9606.ENSP00000337452Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By si [...]
WFDC10B protein networkhttps://string-db.org/network/9606.ENSP00000337466Protein WFDC10B; WAP four-disulfide core domain 10B.
ZNF324B protein networkhttps://string-db.org/network/9606.ENSP00000337473Zinc finger protein 324B; May be involved in transcriptional regulation.
SINHCAF protein networkhttps://string-db.org/network/9606.ENSP00000337477SIN3-HDAC complex-associated factor; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathw [...]
ARL17A protein networkhttps://string-db.org/network/9606.ENSP00000337478ADP-ribosylation factor-like protein 17; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein traff [...]
PCGF5 protein networkhttps://string-db.org/network/9606.ENSP00000337500Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes [...]
NRIP2 protein networkhttps://string-db.org/network/9606.ENSP00000337501Nuclear receptor-interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2.
FBXO40 protein networkhttps://string-db.org/network/9606.ENSP00000337510F-box only protein 40; Probable substrate-recognition component of the SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis.
CMTR2 protein networkhttps://string-db.org/network/9606.ENSP00000337512Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Met [...]
SRA1 protein networkhttps://string-db.org/network/9606.ENSP00000337513Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mec [...]
ZNF548 protein networkhttps://string-db.org/network/9606.ENSP00000337555Zinc finger protein 548; May be involved in transcriptional regulation.
DGKH protein networkhttps://string-db.org/network/9606.ENSP00000337572Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathw [...]
GGTLC1 protein networkhttps://string-db.org/network/9606.ENSP00000337587Gamma-glutamyltransferase light chain 1.
LIMS1 protein networkhttps://string-db.org/network/9606.ENSP00000337598LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface re [...]
NIPA2 protein networkhttps://string-db.org/network/9606.ENSP00000337618Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family.
RNASEH2B protein networkhttps://string-db.org/network/9606.ENSP00000337623Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the rem [...]
SARNP protein networkhttps://string-db.org/network/9606.ENSP00000337632SAP domain-containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment reg [...]
PPP2R5E protein networkhttps://string-db.org/network/9606.ENSP00000337641Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...]
EBAG9 protein networkhttps://string-db.org/network/9606.ENSP00000337675Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting [...]
SEC62 protein networkhttps://string-db.org/network/9606.ENSP00000337688Translocation protein SEC62; Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory prot [...]
MAPK15 protein networkhttps://string-db.org/network/9606.ENSP00000337691Mitogen-activated protein kinase 15; Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity [...]
PNPLA2 protein networkhttps://string-db.org/network/9606.ENSP00000337701Patatin-like phospholipase domain-containing protein 2; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase act [...]
CIDEB protein networkhttps://string-db.org/network/9606.ENSP00000337731Cell death activator CIDE-B; Activates apoptosis.
RUNDC3B protein networkhttps://string-db.org/network/9606.ENSP00000337732RUN domain containing 3B.
KLK5 protein networkhttps://string-db.org/network/9606.ENSP00000337733Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily.
ISYNA1 protein networkhttps://string-db.org/network/9606.ENSP00000337746Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rat [...]
PIDD1 protein networkhttps://string-db.org/network/9606.ENSP00000337797P53-induced death domain-containing protein 1; Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associa [...]
SPAG17 protein networkhttps://string-db.org/network/9606.ENSP00000337804Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone [...]
MMP25 protein networkhttps://string-db.org/network/9606.ENSP00000337816Matrix metalloproteinase-25; May activate progelatinase A.
RTN4 protein networkhttps://string-db.org/network/9606.ENSP00000337838Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They infl [...]
KPTN protein networkhttps://string-db.org/network/9606.ENSP00000337850KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR [...]
ZNF576 protein networkhttps://string-db.org/network/9606.ENSP00000337852Zinc finger protein 576; May be involved in transcriptional regulation.
HEXD protein networkhttps://string-db.org/network/9606.ENSP00000337854Hexosaminidase D; Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N- acetylgalactosamine (GalNAc) from cellular substrates. Has a [...]
OVOL1 protein networkhttps://string-db.org/network/9606.ENSP00000337862Putative transcription factor Ovo-like 1; Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital s [...]
MXD4 protein networkhttps://string-db.org/network/9606.ENSP00000337889Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence- specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC [...]
MPP7 protein networkhttps://string-db.org/network/9606.ENSP00000337907MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein c [...]
PACRG protein networkhttps://string-db.org/network/9606.ENSP00000337946Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pae [...]
HTR7 protein networkhttps://string-db.org/network/9606.ENSP000003379495-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...]
GDPD5 protein networkhttps://string-db.org/network/9606.ENSP00000337972Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By sim [...]
SUV39H1 protein networkhttps://string-db.org/network/9606.ENSP00000337976Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates hi [...]
SPTY2D1 protein networkhttps://string-db.org/network/9606.ENSP00000337991Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding [...]
NCKAP5L protein networkhttps://string-db.org/network/9606.ENSP00000337998Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylati [...]
IL21R protein networkhttps://string-db.org/network/9606.ENSP00000338010Interleukin-21 receptor; This is a receptor for interleukin-21.
CCDC183 protein networkhttps://string-db.org/network/9606.ENSP00000338013Coiled-coil domain containing 183.
DNAJB2 protein networkhttps://string-db.org/network/9606.ENSP00000338019DnaJ homolog subfamily B member 2; Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In par [...]
STARD7 protein networkhttps://string-db.org/network/9606.ENSP00000338030StAR-related lipid transfer protein 7, mitochondrial; May play a protective role in mucosal tissues by preventing exaggerated allergic responses.
SPRYD4 protein networkhttps://string-db.org/network/9606.ENSP00000338034SPRY domain containing 4.
PSMF1 protein networkhttps://string-db.org/network/9606.ENSP00000338039Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the ac [...]
MRPL30 protein networkhttps://string-db.org/network/9606.ENSP00000338057Mitochondrial ribosomal protein L30.
HBG2 protein networkhttps://string-db.org/network/9606.ENSP00000338082Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
TARS3 protein networkhttps://string-db.org/network/9606.ENSP00000338093Threonine--tRNA ligase 2, cytoplasmic; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the [...]
TESK1 protein networkhttps://string-db.org/network/9606.ENSP00000338127Dual specificity testis-specific protein kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and [...]
KLRD1 protein networkhttps://string-db.org/network/9606.ENSP00000338130Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
ZBTB16 protein networkhttps://string-db.org/network/9606.ENSP00000338157Zinc finger and BTB domain-containing protein 16; Acts as a transcriptional repressor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tiss [...]
TMEM217 protein networkhttps://string-db.org/network/9606.ENSP00000338164Transmembrane protein 217.
TMEM39B protein networkhttps://string-db.org/network/9606.ENSP00000338165Transmembrane protein 39B; Belongs to the TMEM39 family.
SKAP1 protein networkhttps://string-db.org/network/9606.ENSP00000338171Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T- cells and antigen-presentin [...]
PUM2 protein networkhttps://string-db.org/network/9606.ENSP00000338173Pumilio homolog 2; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Resp [...]
PLCB1 protein networkhttps://string-db.org/network/9606.ENSP000003381851-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...]
EED protein networkhttps://string-db.org/network/9606.ENSP00000338186Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affec [...]
SNTB2 protein networkhttps://string-db.org/network/9606.ENSP00000338191Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and th [...]
LMO1 protein networkhttps://string-db.org/network/9606.ENSP00000338207Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
ZNF532 protein networkhttps://string-db.org/network/9606.ENSP00000338217Zinc finger protein 532; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MTDH protein networkhttps://string-db.org/network/9606.ENSP00000338235Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent grow [...]
CDC42EP4 protein networkhttps://string-db.org/network/9606.ENSP00000338258Cdc42 effector protein 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...]
APOL4 protein networkhttps://string-db.org/network/9606.ENSP00000338260Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity).
HEY1 protein networkhttps://string-db.org/network/9606.ENSP00000338272Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalin [...]
CRISP1 protein networkhttps://string-db.org/network/9606.ENSP00000338276Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family.
NPAS2 protein networkhttps://string-db.org/network/9606.ENSP00000338283Neuronal PAS domain-containing protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various ph [...]
GZF1 protein networkhttps://string-db.org/network/9606.ENSP00000338290GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression.
PAQR6 protein networkhttps://string-db.org/network/9606.ENSP00000338330Membrane progestin receptor delta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis [...]
SGCD protein networkhttps://string-db.org/network/9606.ENSP00000338343Delta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
UBE2G2 protein networkhttps://string-db.org/network/9606.ENSP00000338348Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved [...]
NUDT4 protein networkhttps://string-db.org/network/9606.ENSP00000338352Diphosphoinositol polyphosphate phosphohydrolase NUDT4B; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiph [...]
CELA3B protein networkhttps://string-db.org/network/9606.ENSP00000338369Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity.
MRPL35 protein networkhttps://string-db.org/network/9606.ENSP00000338389Mitochondrial ribosomal protein L35.
UBA1 protein networkhttps://string-db.org/network/9606.ENSP00000338413Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquit [...]
MGAT4B protein networkhttps://string-db.org/network/9606.ENSP00000338487Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N- [...]
AGTPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000338512Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...]
FAM53B protein networkhttps://string-db.org/network/9606.ENSP00000338532Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization.
TTC33 protein networkhttps://string-db.org/network/9606.ENSP00000338533Tetratricopeptide repeat domain 33.
STX3 protein networkhttps://string-db.org/network/9606.ENSP00000338562Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones.
ZNF212 protein networkhttps://string-db.org/network/9606.ENSP00000338572Zinc finger protein 212; May be involved in transcriptional regulation.
THEM6 protein networkhttps://string-db.org/network/9606.ENSP00000338607Protein THEM6; Thioesterase superfamily member 6.
CRYGN protein networkhttps://string-db.org/network/9606.ENSP00000338613Crystallin gamma N.
TASP1 protein networkhttps://string-db.org/network/9606.ENSP00000338624Threonine aspartase subunit alpha; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster. Belongs to the Ntn-hydrolase family.
SLC6A16 protein networkhttps://string-db.org/network/9606.ENSP00000338627Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5; Solute carrier family 6 member 16.
RERE protein networkhttps://string-db.org/network/9606.ENSP00000338629Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits [...]
PWWP3B protein networkhttps://string-db.org/network/9606.ENSP00000338641PWWP domain-containing DNA repair factor 3B; PWWP domain containing 3B; Belongs to the PWWP3A family.
MS4A4A protein networkhttps://string-db.org/network/9606.ENSP00000338648Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex.
RHOBTB1 protein networkhttps://string-db.org/network/9606.ENSP00000338671Rho-related BTB domain-containing protein 1; Rho related BTB domain containing 1.
CDK10 protein networkhttps://string-db.org/network/9606.ENSP00000338673Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the re [...]
UGP2 protein networkhttps://string-db.org/network/9606.ENSP00000338703UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family.
LRRFIP2 protein networkhttps://string-db.org/network/9606.ENSP00000338727Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regul [...]
CCDC88A protein networkhttps://string-db.org/network/9606.ENSP00000338728Girdin; Bifunctional modulator of guanine nucleotide-binding proteins (G proteins). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-bindi [...]
NPHP3 protein networkhttps://string-db.org/network/9606.ENSP00000338766Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt s [...]
ASAP3 protein networkhttps://string-db.org/network/9606.ENSP00000338769Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; Promotes cell proliferation.
ZNF420 protein networkhttps://string-db.org/network/9606.ENSP00000338770Zinc finger protein 420; May be involved in transcriptional regulation.
AP3S2 protein networkhttps://string-db.org/network/9606.ENSP00000338777AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...]
CHST5 protein networkhttps://string-db.org/network/9606.ENSP00000338783Carbohydrate sulfotransferase 5; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...]
STARD13 protein networkhttps://string-db.org/network/9606.ENSP00000338785StAR-related lipid transfer protein 13; GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motili [...]
ZC3H15 protein networkhttps://string-db.org/network/9606.ENSP00000338788Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions.
SSX2 protein networkhttps://string-db.org/network/9606.ENSP00000338796SSX family member 2.
NFAT5 protein networkhttps://string-db.org/network/9606.ENSP00000338806Nuclear factor of activated T-cells 5; Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional respon [...]
ZBTB49 protein networkhttps://string-db.org/network/9606.ENSP00000338807Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. [Isoform 3]: Activates RB1 [...]
C1QTNF6 protein networkhttps://string-db.org/network/9606.ENSP00000338812Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6.
BAG5 protein networkhttps://string-db.org/network/9606.ENSP00000338814BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor f [...]
SEC23B protein networkhttps://string-db.org/network/9606.ENSP00000338844Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
ZNF444 protein networkhttps://string-db.org/network/9606.ENSP00000338860Zinc finger protein 444; Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family.
BRIX1 protein networkhttps://string-db.org/network/9606.ENSP00000338862Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit.
RASGRP2 protein networkhttps://string-db.org/network/9606.ENSP00000338864RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates othe [...]
C2CD2L protein networkhttps://string-db.org/network/9606.ENSP00000338885Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in [...]
LRRC8D protein networkhttps://string-db.org/network/9606.ENSP00000338887Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...]
ZNF385A protein networkhttps://string-db.org/network/9606.ENSP00000338927Zinc finger protein 385A; RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA an [...]
EZR protein networkhttps://string-db.org/network/9606.ENSP00000338934Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical p [...]
GGT7 protein networkhttps://string-db.org/network/9606.ENSP00000338964Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family.
ARHGAP6 protein networkhttps://string-db.org/network/9606.ENSP00000338967Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin [...]
PRELID3A protein networkhttps://string-db.org/network/9606.ENSP00000338988PRELI domain containing protein 3A; In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the m [...]
ATG101 protein networkhttps://string-db.org/network/9606.ENSP00000338990Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation. Belongs to the ATG101 family.
TUBB protein networkhttps://string-db.org/network/9606.ENSP00000339001Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chai [...]
FOXG1 protein networkhttps://string-db.org/network/9606.ENSP00000339004Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telen [...]
ATAD1 protein networkhttps://string-db.org/network/9606.ENSP00000339017ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learnin [...]
ZFP91 protein networkhttps://string-db.org/network/9606.ENSP00000339030E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby act [...]
EEF1A1 protein networkhttps://string-db.org/network/9606.ENSP00000339063Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that ac [...]
FGFBP3 protein networkhttps://string-db.org/network/9606.ENSP00000339067Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix g [...]
RBMX2 protein networkhttps://string-db.org/network/9606.ENSP00000339090RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the IST3 family.
ANAPC1 protein networkhttps://string-db.org/network/9606.ENSP00000339109Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...]
ESPNL protein networkhttps://string-db.org/network/9606.ENSP00000339115Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing.
ERAS protein networkhttps://string-db.org/network/9606.ENSP00000339136GTPase ERas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity); Belongs to the s [...]
RRP1B protein networkhttps://string-db.org/network/9606.ENSP00000339145Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional acti [...]
CPM protein networkhttps://string-db.org/network/9606.ENSP00000339157Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth fac [...]
AIDA protein networkhttps://string-db.org/network/9606.ENSP00000339161Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. [...]
TSSK4 protein networkhttps://string-db.org/network/9606.ENSP00000339179Testis-specific serine/threonine-protein kinase 4; Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre [...]
ATP13A4 protein networkhttps://string-db.org/network/9606.ENSP00000339182ATPase 13A4.
GRAP2 protein networkhttps://string-db.org/network/9606.ENSP00000339186GRB2-related adapter protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.
CAV1 protein networkhttps://string-db.org/network/9606.ENSP00000339191Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the r [...]
DPP8 protein networkhttps://string-db.org/network/9606.ENSP00000339208Dipeptidyl peptidase 8; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2.
KRTAP24-1 protein networkhttps://string-db.org/network/9606.ENSP00000339238Keratin-associated protein 24-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
DPPA3 protein networkhttps://string-db.org/network/9606.ENSP00000339250Developmental pluripotency-associated protein 3; Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA [...]
KRTDAP protein networkhttps://string-db.org/network/9606.ENSP00000339251Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis.
SLC6A13 protein networkhttps://string-db.org/network/9606.ENSP00000339260Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be i [...]
CCDC30 protein networkhttps://string-db.org/network/9606.ENSP00000339280Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family.
TRIO protein networkhttps://string-db.org/network/9606.ENSP00000339299Triple functional domain protein; Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. [...]
ZNF70 protein networkhttps://string-db.org/network/9606.ENSP00000339314Zinc finger protein 70; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SMIM15 protein networkhttps://string-db.org/network/9606.ENSP00000339324Small integral membrane protein 15.
PLAUR protein networkhttps://string-db.org/network/9606.ENSP00000339328Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-inde [...]
KCTD21 protein networkhttps://string-db.org/network/9606.ENSP00000339340BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal [...]
KLRG2 protein networkhttps://string-db.org/network/9606.ENSP00000339356Killer cell lectin like receptor G2.
LGALS12 protein networkhttps://string-db.org/network/9606.ENSP00000339374Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.
RGS12 protein networkhttps://string-db.org/network/9606.ENSP00000339381Regulator of G-protein signaling 12; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...]
OTUD6A protein networkhttps://string-db.org/network/9606.ENSP00000339389OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.
CDH26 protein networkhttps://string-db.org/network/9606.ENSP00000339390Cadherin-like protein 26; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contr [...]
HLA-DQA1 protein networkhttps://string-db.org/network/9606.ENSP00000339398Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family.
ASCC1 protein networkhttps://string-db.org/network/9606.ENSP00000339404Activating signal cointegrator 1 complex subunit 1; Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF- kappa-B, SRF and AP1 transactiv [...]
TP53TG3B protein networkhttps://string-db.org/network/9606.ENSP00000339405TP53-target gene 3 protein; May play a significant role in p53/TP53-mediating signaling pathway.
SRR protein networkhttps://string-db.org/network/9606.ENSP00000339435Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
CFAP52 protein networkhttps://string-db.org/network/9606.ENSP00000339449Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family.
RHOG protein networkhttps://string-db.org/network/9606.ENSP00000339467Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structur [...]
ICOSLG protein networkhttps://string-db.org/network/9606.ENSP00000339477Ig-like domain-containing protein; Inducible T cell costimulator ligand.
NT5C2 protein networkhttps://string-db.org/network/9606.ENSP00000339479Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Pre [...]
ZFAND4 protein networkhttps://string-db.org/network/9606.ENSP00000339484Zinc finger AN1-type containing 4.
NELFB protein networkhttps://string-db.org/network/9606.ENSP00000339495Negative elongation factor B; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...]
H2AP protein networkhttps://string-db.org/network/9606.ENSP00000339511Huntingtin-interacting protein M; H2A.P histone.
DFFB protein networkhttps://string-db.org/network/9606.ENSP00000339524DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
FOXO3 protein networkhttps://string-db.org/network/9606.ENSP00000339527Forkhead box protein O3; Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a [...]
THUMPD3 protein networkhttps://string-db.org/network/9606.ENSP00000339532THUMP domain containing 3.
H1-2 protein networkhttps://string-db.org/network/9606.ENSP00000339566Histone H1.2; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...]
RHD protein networkhttps://string-db.org/network/9606.ENSP00000339577Rh blood group D antigen; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
ZNF449 protein networkhttps://string-db.org/network/9606.ENSP00000339585Zinc finger protein 449; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GSDME protein networkhttps://string-db.org/network/9606.ENSP00000339587Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53.
POFUT2 protein networkhttps://string-db.org/network/9606.ENSP00000339613GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2 [...]
LCN6 protein networkhttps://string-db.org/network/9606.ENSP00000339621Epididymal-specific lipocalin-6; May play a role in male fertility.
SLC35E4 protein networkhttps://string-db.org/network/9606.ENSP00000339626Solute carrier family 35 member E4; Putative transporter.
KIR2DL4 protein networkhttps://string-db.org/network/9606.ENSP00000339634Killer cell immunoglobulin-like receptor 2DL4; Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a noname [...]
BRAT1 protein networkhttps://string-db.org/network/9606.ENSP00000339637BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Play [...]
TRIM2 protein networkhttps://string-db.org/network/9606.ENSP00000339659Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May p [...]
RASSF4 protein networkhttps://string-db.org/network/9606.ENSP00000339692Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.
NDUFA4 protein networkhttps://string-db.org/network/9606.ENSP00000339720Cytochrome c oxidase subunit NDUFA4; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory c [...]
CIR1 protein networkhttps://string-db.org/network/9606.ENSP00000339723Corepressor interacting with RBPJ 1; May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruit [...]
OR14I1 protein networkhttps://string-db.org/network/9606.ENSP00000339726Olfactory receptor 14I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
THBS4 protein networkhttps://string-db.org/network/9606.ENSP00000339730Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and [...]
ARL4C protein networkhttps://string-db.org/network/9606.ENSP00000339754ADP-ribosylation factor-like protein 4C; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...]
PRDM8 protein networkhttps://string-db.org/network/9606.ENSP00000339764PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcripti [...]
ZNF433 protein networkhttps://string-db.org/network/9606.ENSP00000339767Zinc finger protein 433; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ACSL4 protein networkhttps://string-db.org/network/9606.ENSP00000339787Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Pr [...]
RPL7 protein networkhttps://string-db.org/network/9606.ENSP0000033979560S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free t [...]
IDS protein networkhttps://string-db.org/network/9606.ENSP00000339801Iduronate 2-sulfatase 14 kDa chain; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate.
ANKRD34B protein networkhttps://string-db.org/network/9606.ENSP00000339802Ankyrin repeat domain 34B; Belongs to the ANKRD34 family.
TSLP protein networkhttps://string-db.org/network/9606.ENSP00000339804Thymic stromal lymphopoietin; [Isoform 1]: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cell [...]
TPST2 protein networkhttps://string-db.org/network/9606.ENSP00000339813Protein-tyrosine sulfotransferase 2; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
ZNF546 protein networkhttps://string-db.org/network/9606.ENSP00000339823Zinc finger protein 546; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FGFR3 protein networkhttps://string-db.org/network/9606.ENSP00000339824Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, [...]
PIK3AP1 protein networkhttps://string-db.org/network/9606.ENSP00000339826Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signa [...]
TMEM220 protein networkhttps://string-db.org/network/9606.ENSP00000339830Transmembrane protein 220.
SNRNP48 protein networkhttps://string-db.org/network/9606.ENSP00000339834U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5' splice site recognition.
H3-5 protein networkhttps://string-db.org/network/9606.ENSP00000339835Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...]
MRPL43 protein networkhttps://string-db.org/network/9606.ENSP00000339844Mitochondrial ribosomal protein L43.
DPYSL4 protein networkhttps://string-db.org/network/9606.ENSP00000339850Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse a [...]
CLCN1 protein networkhttps://string-db.org/network/9606.ENSP00000339867Chloride channel protein 1; Voltage-gated chloride channel. Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. Belongs to the chloride channel ( [...]
MIOS protein networkhttps://string-db.org/network/9606.ENSP00000339881GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 [...]
LBR protein networkhttps://string-db.org/network/9606.ENSP00000339883Delta(14)-sterol reductase LBR; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in m [...]
FLRT3 protein networkhttps://string-db.org/network/9606.ENSP00000339912Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. [...]
LIMK2 protein networkhttps://string-db.org/network/9606.ENSP00000339916LIM domain kinase 2; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pa [...]
TAF9B protein networkhttps://string-db.org/network/9606.ENSP00000339917Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of [...]
XRRA1 protein networkhttps://string-db.org/network/9606.ENSP00000339918X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation.
PKLR protein networkhttps://string-db.org/network/9606.ENSP00000339933Pyruvate kinase PKLR; Plays a key role in glycolysis.
MROH8 protein networkhttps://string-db.org/network/9606.ENSP00000339971Protein MROH8; Maestro heat like repeat family member 8.
TBC1D28 protein networkhttps://string-db.org/network/9606.ENSP00000339973TBC1 domain family member 28.
TAF1A protein networkhttps://string-db.org/network/9606.ENSP00000339976TATA box-binding protein-associated factor RNA polymerase I subunit A; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation compl [...]
MYB protein networkhttps://string-db.org/network/9606.ENSP00000339992Transcriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and [...]
ZNF564 protein networkhttps://string-db.org/network/9606.ENSP00000340004Zinc finger protein 564; May be involved in transcriptional regulation.
HSPD1 protein networkhttps://string-db.org/network/9606.ENSP0000034001960 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported prote [...]
KRCC1 protein networkhttps://string-db.org/network/9606.ENSP00000340083Lysine rich coiled-coil 1.
THEG protein networkhttps://string-db.org/network/9606.ENSP00000340088Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis.
PPP1R17 protein networkhttps://string-db.org/network/9606.ENSP00000340125Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.
ZNF383 protein networkhttps://string-db.org/network/9606.ENSP00000340132Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.
RBPMS protein networkhttps://string-db.org/network/9606.ENSP00000340176RNA-binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to inc [...]
GLYAT protein networkhttps://string-db.org/network/9606.ENSP00000340200Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrate [...]
CORO1B protein networkhttps://string-db.org/network/9606.ENSP00000340211Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).
TMEM202 protein networkhttps://string-db.org/network/9606.ENSP00000340212Transmembrane protein 202.
C7orf26 protein networkhttps://string-db.org/network/9606.ENSP00000340220Uncharacterized protein C7orf26; Chromosome 7 open reading frame 26.
LMX1A protein networkhttps://string-db.org/network/9606.ENSP00000340226LIM homeobox transcription factor 1-alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the [...]
SERINC3 protein networkhttps://string-db.org/network/9606.ENSP00000340243Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the vira [...]
TAF3 protein networkhttps://string-db.org/network/9606.ENSP00000340271Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeri [...]
PARK7 protein networkhttps://string-db.org/network/9606.ENSP00000340278Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive ca [...]
SSX2IP protein networkhttps://string-db.org/network/9606.ENSP00000340279Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Ma [...]
DLK1 protein networkhttps://string-db.org/network/9606.ENSP00000340292Protein delta homolog 1; May have a role in neuroendocrine differentiation.
ACSM6 protein networkhttps://string-db.org/network/9606.ENSP00000340296Acyl-coenzyme A synthetase ACSM6, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Belongs to the ATP-dependent AMP-b [...]
ZDHHC1 protein networkhttps://string-db.org/network/9606.ENSP00000340299Probable palmitoyltransferase ZDHHC1; Zinc finger DHHC-type containing 1; Belongs to the DHHC palmitoyltransferase family.
UBE2V1 protein networkhttps://string-db.org/network/9606.ENSP00000340305Ubiquitin conjugating enzyme E2 V1.
NYX protein networkhttps://string-db.org/network/9606.ENSP00000340328Nyctalopin.
CAPRIN1 protein networkhttps://string-db.org/network/9606.ENSP00000340329Caprin-1; May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly an [...]
KAT5 protein networkhttps://string-db.org/network/9606.ENSP00000340330Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...]
TCF7 protein networkhttps://string-db.org/network/9606.ENSP00000340347Transcription factor 7; Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal C [...]
ACVR2B protein networkhttps://string-db.org/network/9606.ENSP00000340361Activin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or [...]
DYRK1A protein networkhttps://string-db.org/network/9606.ENSP00000340373Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway [...]
SLC15A5 protein networkhttps://string-db.org/network/9606.ENSP00000340402Solute carrier family 15 member 5; Proton oligopeptide cotransporter.
SMPD1 protein networkhttps://string-db.org/network/9606.ENSP00000340409Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 3 l [...]
ERMP1 protein networkhttps://string-db.org/network/9606.ENSP00000340427Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family.
RTL6 protein networkhttps://string-db.org/network/9606.ENSP00000340434Retrotransposon Gag like 6.
SAXO2 protein networkhttps://string-db.org/network/9606.ENSP00000340445Stabilizer of axonemal microtubules 2.
RAP1GDS1 protein networkhttps://string-db.org/network/9606.ENSP00000340454Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP- binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating t [...]
GANAB protein networkhttps://string-db.org/network/9606.ENSP00000340466Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precur [...]
CARMIL3 protein networkhttps://string-db.org/network/9606.ENSP00000340467Capping protein regulator and myosin 1 linker 3; Belongs to the CARMIL family.
EXD3 protein networkhttps://string-db.org/network/9606.ENSP00000340474Exonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity); Belongs to the mut-7 family.
ZNF395 protein networkhttps://string-db.org/network/9606.ENSP00000340494Zinc finger protein 395; Plays a role in papillomavirus genes transcription.
SENP8 protein networkhttps://string-db.org/network/9606.ENSP00000340505Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted prot [...]
TRIM24 protein networkhttps://string-db.org/network/9606.ENSP00000340507Transcription intermediary factor 1-alpha; Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts w [...]
PPL protein networkhttps://string-db.org/network/9606.ENSP00000340510Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated si [...]
ZNF14 protein networkhttps://string-db.org/network/9606.ENSP00000340514Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
LRRC37B protein networkhttps://string-db.org/network/9606.ENSP00000340519Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B.
UTS2B protein networkhttps://string-db.org/network/9606.ENSP00000340526Urotensin-2B; Potent vasoconstrictor; Belongs to the urotensin-2 family.
KRTAP4-5 protein networkhttps://string-db.org/network/9606.ENSP00000340546Keratin-associated protein 4-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
COX8C protein networkhttps://string-db.org/network/9606.ENSP00000340568Cytochrome c oxidase subunit 8C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
RASSF6 protein networkhttps://string-db.org/network/9606.ENSP00000340578Ras association domain-containing protein 6; Involved in the induction of apoptosis, through both caspase- dependent and caspase-independent pathways. May act as a Ras effector protein. May suppr [...]
RTL4 protein networkhttps://string-db.org/network/9606.ENSP00000340590Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system.
SYDE2 protein networkhttps://string-db.org/network/9606.ENSP00000340594Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
UBE3B protein networkhttps://string-db.org/network/9606.ENSP00000340596Ubiquitin-protein ligase E3B; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to t [...]
SGK2 protein networkhttps://string-db.org/network/9606.ENSP00000340608Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proli [...]
DUPD1 protein networkhttps://string-db.org/network/9606.ENSP00000340609Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a s [...]
POTEH protein networkhttps://string-db.org/network/9606.ENSP00000340610POTE ankyrin domain family member H.
TERB2 protein networkhttps://string-db.org/network/9606.ENSP00000340644Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homolo [...]
HUWE1 protein networkhttps://string-db.org/network/9606.ENSP00000340648E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyu [...]
ELSPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000340660Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity); Belongs to the seminal [...]
TMEM248 protein networkhttps://string-db.org/network/9606.ENSP00000340668Transmembrane protein 248.
ARMCX3 protein networkhttps://string-db.org/network/9606.ENSP00000340672Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its inte [...]
WNT8B protein networkhttps://string-db.org/network/9606.ENSP00000340677Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, nota [...]
ZNF823 protein networkhttps://string-db.org/network/9606.ENSP00000340683Zinc finger protein 823; May be involved in transcriptional regulation.
MAOA protein networkhttps://string-db.org/network/9606.ENSP00000340684Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in th [...]
ADGRL1 protein networkhttps://string-db.org/network/9606.ENSP00000340688Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive ex [...]
EIF4EBP1 protein networkhttps://string-db.org/network/9606.ENSP00000340691Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphoryla [...]
GYG1 protein networkhttps://string-db.org/network/9606.ENSP00000340736Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Belongs to the glycosyltransferase 8 family. Gly [...]
OR13H1 protein networkhttps://string-db.org/network/9606.ENSP00000340748Olfactory receptor 13H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CFAP65 protein networkhttps://string-db.org/network/9606.ENSP00000340776Cilia- and flagella-associated protein 65; May play a role in sperm motility. Belongs to the CFAP65 family.
ZNF326 protein networkhttps://string-db.org/network/9606.ENSP00000340796DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates tran [...]
GJB5 protein networkhttps://string-db.org/network/9606.ENSP00000340811Gap junction beta-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
MAPT protein networkhttps://string-db.org/network/9606.ENSP00000340820Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal micro [...]
GTF2F2 protein networkhttps://string-db.org/network/9606.ENSP00000340823General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration w [...]
OSTF1 protein networkhttps://string-db.org/network/9606.ENSP00000340836Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
ZC3H12B protein networkhttps://string-db.org/network/9606.ENSP00000340839Probable ribonuclease ZC3H12B; May function as RNase and regulate the levels of target RNA species.
ZNF621 protein networkhttps://string-db.org/network/9606.ENSP00000340841Zinc finger protein 621; May be involved in transcriptional regulation.
C1QTNF1 protein networkhttps://string-db.org/network/9606.ENSP00000340864Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1.
MEF2C protein networkhttps://string-db.org/network/9606.ENSP00000340874Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphog [...]
SMARCB1 protein networkhttps://string-db.org/network/9606.ENSP00000340883SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays [...]
C5orf47 protein networkhttps://string-db.org/network/9606.ENSP00000340887Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47.
ASH2L protein networkhttps://string-db.org/network/9606.ENSP00000340896Set1/Ash2 histone methyltransferase complex subunit ASH2; Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not [...]
MIA3 protein networkhttps://string-db.org/network/9606.ENSP00000340900Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated [...]
TRPC6 protein networkhttps://string-db.org/network/9606.ENSP00000340913Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...]
SYT3 protein networkhttps://string-db.org/network/9606.ENSP00000340914Synaptotagmin-3; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to [...]
DMP1 protein networkhttps://string-db.org/network/9606.ENSP00000340935Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional [...]
CLDN18 protein networkhttps://string-db.org/network/9606.ENSP00000340939Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
CRHR2 protein networkhttps://string-db.org/network/9606.ENSP00000340943Corticotropin-releasing factor receptor 2; G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a [...]
CNBD2 protein networkhttps://string-db.org/network/9606.ENSP00000340954Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the [...]
SOWAHD protein networkhttps://string-db.org/network/9606.ENSP00000340975Ankyrin repeat domain-containing protein SOWAHD; Sosondowah ankyrin repeat domain family member D; Belongs to the SOWAH family.
RNF175 protein networkhttps://string-db.org/network/9606.ENSP00000340979Ring finger protein 175.
SPAG8 protein networkhttps://string-db.org/network/9606.ENSP00000340982Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of C [...]
LRRC25 protein networkhttps://string-db.org/network/9606.ENSP00000340983Leucine-rich repeat-containing protein 25; Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specif [...]
LDLRAD2 protein networkhttps://string-db.org/network/9606.ENSP00000340988Low density lipoprotein receptor class A domain containing 2.
SFN protein networkhttps://string-db.org/network/9606.ENSP0000034098914-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognit [...]
NTN4 protein networkhttps://string-db.org/network/9606.ENSP00000340998Netrin-4; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.
AMTN protein networkhttps://string-db.org/network/9606.ENSP00000341013Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of a [...]
NANOS2 protein networkhttps://string-db.org/network/9606.ENSP00000341021Nanos homolog 2; Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis [...]
CSN2 protein networkhttps://string-db.org/network/9606.ENSP00000341030Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family.
TPRG1 protein networkhttps://string-db.org/network/9606.ENSP00000341031Tumor protein p63 regulated 1; Belongs to the TPRG1 family.
WNT7B protein networkhttps://string-db.org/network/9606.ENSP00000341032Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal fusion of the c [...]
ACACB protein networkhttps://string-db.org/network/9606.ENSP00000341044Acetyl-CoA carboxylase 2; Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism. Catalyzes a 2 steps reaction starti [...]
UGT2B15 protein networkhttps://string-db.org/network/9606.ENSP00000341045UDP-glucuronosyltransferase 2B15; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays act [...]
CLEC18B protein networkhttps://string-db.org/network/9606.ENSP00000341051C-type lectin domain family 18 member B; Binds polysaccharides in a Ca(2+)-independent manner (By similarity).
ARHGEF3 protein networkhttps://string-db.org/network/9606.ENSP00000341071Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
MRPL20 protein networkhttps://string-db.org/network/9606.ENSP00000341082Mitochondrial ribosomal protein L20.
NPR2 protein networkhttps://string-db.org/network/9606.ENSP00000341083Atrial natriuretic peptide receptor 2; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation o [...]
H2AC7 protein networkhttps://string-db.org/network/9606.ENSP00000341094Histone H2A type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
HMX2 protein networkhttps://string-db.org/network/9606.ENSP00000341108Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development; Belongs to the HMX homeobox family.
SDSL protein networkhttps://string-db.org/network/9606.ENSP00000341117Serine dehydratase-like; Has low serine dehydratase and threonine dehydratase activity.
C3orf62 protein networkhttps://string-db.org/network/9606.ENSP00000341139Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62.
SIGLEC1 protein networkhttps://string-db.org/network/9606.ENSP00000341141Sialoadhesin; Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including [...]
CERKL protein networkhttps://string-db.org/network/9606.ENSP00000341159Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.
ZNF772 protein networkhttps://string-db.org/network/9606.ENSP00000341165Zinc finger protein 772; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PTN protein networkhttps://string-db.org/network/9606.ENSP00000341170Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sul [...]
MTSS2 protein networkhttps://string-db.org/network/9606.ENSP00000341171Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin b [...]
C15orf62 protein networkhttps://string-db.org/network/9606.ENSP00000341178Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62.
PTK2 protein networkhttps://string-db.org/network/9606.ENSP00000341189Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation a [...]
NEO1 protein networkhttps://string-db.org/network/9606.ENSP00000341198Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. [...]
CHST4 protein networkhttps://string-db.org/network/9606.ENSP00000341206Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...]
STAT5A protein networkhttps://string-db.org/network/9606.ENSP00000341208Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and ot [...]
RAB5IF protein networkhttps://string-db.org/network/9606.ENSP00000341213RAB5 interacting factor.
H1-6 protein networkhttps://string-db.org/network/9606.ENSP00000341214Histone H1t; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin archite [...]
ZNF695 protein networkhttps://string-db.org/network/9606.ENSP00000341236Zinc finger protein 695; May be involved in transcriptional regulation.
RBPJL protein networkhttps://string-db.org/network/9606.ENSP00000341243Recombining binding protein suppressor of hairless-like protein; Putative transcription factor, which cooperates with EBNA2 to activate transcription; Belongs to the Su(H) family.
GSPT2 protein networkhttps://string-db.org/network/9606.ENSP00000341247Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulat [...]
TRADD protein networkhttps://string-db.org/network/9606.ENSP00000341268Tumor necrosis factor receptor type 1-associated DEATH domain protein; The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by [...]
JARID2 protein networkhttps://string-db.org/network/9606.ENSP00000341280Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hema [...]
TUBB4B protein networkhttps://string-db.org/network/9606.ENSP00000341289Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...]
WNK1 protein networkhttps://string-db.org/network/9606.ENSP00000341292Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an a [...]
SRFBP1 protein networkhttps://string-db.org/network/9606.ENSP00000341324Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of S [...]
KLHL6 protein networkhttps://string-db.org/network/9606.ENSP00000341342Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
TEKT1 protein networkhttps://string-db.org/network/9606.ENSP00000341346Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family.
DCAF5 protein networkhttps://string-db.org/network/9606.ENSP00000341351DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
RNF13 protein networkhttps://string-db.org/network/9606.ENSP00000341361E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of J [...]
TMEM230 protein networkhttps://string-db.org/network/9606.ENSP00000341364Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family.
C6orf132 protein networkhttps://string-db.org/network/9606.ENSP00000341368Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132.
SMC4 protein networkhttps://string-db.org/network/9606.ENSP00000341382Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The [...]
PLET1 protein networkhttps://string-db.org/network/9606.ENSP00000341412Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a ro [...]
P4HTM protein networkhttps://string-db.org/network/9606.ENSP00000341422Transmembrane prolyl 4-hydroxylase; Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564' [...]
SNTN protein networkhttps://string-db.org/network/9606.ENSP00000341442Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules.
RANBP3 protein networkhttps://string-db.org/network/9606.ENSP00000341483Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In [...]
SYDE1 protein networkhttps://string-db.org/network/9606.ENSP00000341489Rho GTPase-activating protein SYDE1; GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells m [...]
ISM2 protein networkhttps://string-db.org/network/9606.ENSP00000341490Isthmin-2; Isthmin 2.
SEPTIN6 protein networkhttps://string-db.org/network/9606.ENSP00000341524Septin-6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous st [...]
ZNF34 protein networkhttps://string-db.org/network/9606.ENSP00000341528Zinc finger protein 34; May be involved in transcriptional regulation.
TCAIM protein networkhttps://string-db.org/network/9606.ENSP00000341539T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis.
KLHL33 protein networkhttps://string-db.org/network/9606.ENSP00000341549Kelch-like protein 33; Kelch like family member 33.
SLC24A5 protein networkhttps://string-db.org/network/9606.ENSP00000341550Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. P [...]
SMAD4 protein networkhttps://string-db.org/network/9606.ENSP00000341551Mothers against decapentaplegic homolog 4; In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phospho [...]
B4GALNT1 protein networkhttps://string-db.org/network/9606.ENSP00000341562Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.
PAQR9 protein networkhttps://string-db.org/network/9606.ENSP00000341564Membrane progestin receptor epsilon; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signali [...]
FAM111B protein networkhttps://string-db.org/network/9606.ENSP00000341565Protein FAM111B; Family with sequence similarity 111 member B; Belongs to the FAM111 family.
OR52B6 protein networkhttps://string-db.org/network/9606.ENSP00000341581Olfactory receptor 52B6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FAM114A2 protein networkhttps://string-db.org/network/9606.ENSP00000341597Protein FAM114A2; Family with sequence similarity 114 member A2; Belongs to the FAM114 family.
C15orf48 protein networkhttps://string-db.org/network/9606.ENSP00000341610Normal mucosa of esophagus-specific gene 1 protein; Chromosome 15 open reading frame 48; Belongs to the complex I NDUFA4 subunit family.
CYB5A protein networkhttps://string-db.org/network/9606.ENSP00000341625Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
NCR3LG1 protein networkhttps://string-db.org/network/9606.ENSP00000341637Natural cytotoxicity triggering receptor 3 ligand 1; Triggers NCR3-dependent natural killer cell activation.
THYN1 protein networkhttps://string-db.org/network/9606.ENSP00000341657Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
AGMO protein networkhttps://string-db.org/network/9606.ENSP00000341662Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.
TPD52L3 protein networkhttps://string-db.org/network/9606.ENSP00000341677Tumor protein D55; TPD52 like 3; Belongs to the TPD52 family.
DTNBP1 protein networkhttps://string-db.org/network/9606.ENSP00000341680Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with [...]
CCDC15 protein networkhttps://string-db.org/network/9606.ENSP00000341684Coiled-coil domain containing 15.
ENSA protein networkhttps://string-db.org/network/9606.ENSP00000341743Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with [...]
BSPH1 protein networkhttps://string-db.org/network/9606.ENSP00000341762Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phosph [...]
SPATA16 protein networkhttps://string-db.org/network/9606.ENSP00000341765Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
PPP1CC protein networkhttps://string-db.org/network/9606.ENSP00000341779Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate h [...]
ADIPOR1 protein networkhttps://string-db.org/network/9606.ENSP00000341785Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and f [...]
BTNL3 protein networkhttps://string-db.org/network/9606.ENSP00000341787Butyrophilin-like protein 3; Butyrophilin like 3.
TCTEX1D4 protein networkhttps://string-db.org/network/9606.ENSP00000341803Tctex1 domain containing 4.
PHF10 protein networkhttps://string-db.org/network/9606.ENSP00000341805PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is requir [...]
SOX18 protein networkhttps://string-db.org/network/9606.ENSP00000341815Transcription factor SOX-18; Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular d [...]
VWC2 protein networkhttps://string-db.org/network/9606.ENSP00000341819Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity).
FPR3 protein networkhttps://string-db.org/network/9606.ENSP00000341821N-formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutro [...]
HNRNPA1 protein networkhttps://string-db.org/network/9606.ENSP00000341826Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may [...]
TNNI3 protein networkhttps://string-db.org/network/9606.ENSP00000341838Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
ETV7 protein networkhttps://string-db.org/network/9606.ENSP00000341843Transcription factor ETV7; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor [...]
RIOK3 protein networkhttps://string-db.org/network/9606.ENSP00000341874Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA vir [...]
RPS2 protein networkhttps://string-db.org/network/9606.ENSP00000341885Ribosomal protein S2.
RASAL3 protein networkhttps://string-db.org/network/9606.ENSP00000341905RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regul [...]
PALM protein networkhttps://string-db.org/network/9606.ENSP00000341911Paralemmin-1; Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation a [...]
PTCHD4 protein networkhttps://string-db.org/network/9606.ENSP00000341914Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, includi [...]
CAV3 protein networkhttps://string-db.org/network/9606.ENSP00000341940Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-ga [...]
ATP13A5 protein networkhttps://string-db.org/network/9606.ENSP00000341942ATPase 13A5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
LRRC66 protein networkhttps://string-db.org/network/9606.ENSP00000341944Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66.
LIN54 protein networkhttps://string-db.org/network/9606.ENSP00000341947Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds [...]
TP53BP2 protein networkhttps://string-db.org/network/9606.ENSP00000341957Apoptosis-stimulating of p53 protein 2; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing [...]
FOXD4L3 protein networkhttps://string-db.org/network/9606.ENSP00000341961Forkhead box D4 like 3.
RSC1A1 protein networkhttps://string-db.org/network/9606.ENSP00000341963Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Als [...]
SPATA31D1 protein networkhttps://string-db.org/network/9606.ENSP00000341988Spermatogenesis-associated protein 31D1; May play a role in spermatogenesis; Belongs to the SPATA31 family.
NANOS3 protein networkhttps://string-db.org/network/9606.ENSP00000341992Nanos homolog 3; Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell pro [...]
ZNF93 protein networkhttps://string-db.org/network/9606.ENSP00000342002Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expres [...]
CYP1A2 protein networkhttps://string-db.org/network/9606.ENSP00000342007Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molec [...]
DMKN protein networkhttps://string-db.org/network/9606.ENSP00000342012Dermokine; May act as a soluble regulator of keratinocyte differentiation.
COX19 protein networkhttps://string-db.org/network/9606.ENSP00000342015Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be requir [...]
ZNF189 protein networkhttps://string-db.org/network/9606.ENSP00000342019Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FBXO38 protein networkhttps://string-db.org/network/9606.ENSP00000342023F-box only protein 38; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...]
PRDX6 protein networkhttps://string-db.org/network/9606.ENSP00000342026Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain or [...]
CS protein networkhttps://string-db.org/network/9606.ENSP00000342056Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.
SLPI protein networkhttps://string-db.org/network/9606.ENSP00000342082Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial [...]
OBP2A protein networkhttps://string-db.org/network/9606.ENSP00000342097Odorant binding protein 2A; Belongs to the calycin superfamily. Lipocalin family.
SPINT1 protein networkhttps://string-db.org/network/9606.ENSP00000342098Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
DYRK2 protein networkhttps://string-db.org/network/9606.ENSP00000342105Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of [...]
SERPINA12 protein networkhttps://string-db.org/network/9606.ENSP00000342109Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. Belongs to the serpin family.
ICAM4 protein networkhttps://string-db.org/network/9606.ENSP00000342114Intercellular adhesion molecule 4; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha- 4/beta-1 and alpha-V integrins.
HHIPL2 protein networkhttps://string-db.org/network/9606.ENSP00000342118HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family.
CREB3 protein networkhttps://string-db.org/network/9606.ENSP00000342136Processed cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a rol [...]
NCCRP1 protein networkhttps://string-db.org/network/9606.ENSP00000342137F-box only protein 50; Promotes cell proliferation.
PDZK1 protein networkhttps://string-db.org/network/9606.ENSP00000342143Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apica [...]
EVC2 protein networkhttps://string-db.org/network/9606.ENSP00000342144Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryoni [...]
TMEM167B protein networkhttps://string-db.org/network/9606.ENSP00000342148Protein kish-B; Involved in the early part of the secretory pathway. Belongs to the KISH family.
NCR3 protein networkhttps://string-db.org/network/9606.ENSP00000342156Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells [...]
TMEM221 protein networkhttps://string-db.org/network/9606.ENSP00000342162Transmembrane protein 221.
TEX9 protein networkhttps://string-db.org/network/9606.ENSP00000342169Testis-expressed protein 9; Testis expressed 9.
LRRIQ4 protein networkhttps://string-db.org/network/9606.ENSP00000342188Leucine rich repeats and IQ motif containing 4.
BTNL8 protein networkhttps://string-db.org/network/9606.ENSP00000342197Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Be [...]
KIR2DL3 protein networkhttps://string-db.org/network/9606.ENSP00000342215Killer cell immunoglobulin-like receptor 2DL3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA- Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysi [...]
ABCA9 protein networkhttps://string-db.org/network/9606.ENSP00000342216ATP-binding cassette sub-family A member 9; May play a role in monocyte differentiation and lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family.
TRPV2 protein networkhttps://string-db.org/network/9606.ENSP00000342222Transient receptor potential cation channel subfamily V member 2; Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF- I [...]
ERBB4 protein networkhttps://string-db.org/network/9606.ENSP00000342235Receptor tyrosine-protein kinase erbB-4; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the hear [...]
XAGE5 protein networkhttps://string-db.org/network/9606.ENSP00000342240X antigen family member 5; Belongs to the GAGE family.
C15orf61 protein networkhttps://string-db.org/network/9606.ENSP00000342254Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61.
NUP43 protein networkhttps://string-db.org/network/9606.ENSP00000342262Nucleoporin Nup43; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex [...]
SLC25A15 protein networkhttps://string-db.org/network/9606.ENSP00000342267Mitochondrial ornithine transporter 1; Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix [...]
SNX18 protein networkhttps://string-db.org/network/9606.ENSP00000342276Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. [...]
OAS2 protein networkhttps://string-db.org/network/9606.ENSP000003422782'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded [...]
ANKRD55 protein networkhttps://string-db.org/network/9606.ENSP00000342295Ankyrin repeat domain 55.
FOXM1 protein networkhttps://string-db.org/network/9606.ENSP00000342307Forkhead box protein M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays a [...]
SAMD11 protein networkhttps://string-db.org/network/9606.ENSP00000342313Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development.
TM7SF3 protein networkhttps://string-db.org/network/9606.ENSP00000342322Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is [...]
BORCS7 protein networkhttps://string-db.org/network/9606.ENSP00000342331BLOC-1-related complex subunit 7; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...]
FAM180A protein networkhttps://string-db.org/network/9606.ENSP00000342336Protein FAM180A; Family with sequence similarity 180 member A.
NRF1 protein networkhttps://string-db.org/network/9606.ENSP00000342351Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth an [...]
OSTN protein networkhttps://string-db.org/network/9606.ENSP00000342356Processed Osteocrin; Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarizati [...]
SNRPD2 protein networkhttps://string-db.org/network/9606.ENSP00000342374Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, [...]
PTGES protein networkhttps://string-db.org/network/9606.ENSP00000342385Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2); Belongs to the MAPEG family.
MESP2 protein networkhttps://string-db.org/network/9606.ENSP00000342392Mesoderm posterior protein 2; Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates a [...]
NRN1L protein networkhttps://string-db.org/network/9606.ENSP00000342411Neuritin-like protein; Neuritin 1 like.
BAZ1B protein networkhttps://string-db.org/network/9606.ENSP00000342434Tyrosine-protein kinase BAZ1B; Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phospho [...]
OR5W2 protein networkhttps://string-db.org/network/9606.ENSP00000342448Olfactory receptor 5W2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ATP9A protein networkhttps://string-db.org/network/9606.ENSP00000342481Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A.
TSTD2 protein networkhttps://string-db.org/network/9606.ENSP00000342499Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2; Thiosulfate sulfurtransferase like domain containing 2.
MFSD2B protein networkhttps://string-db.org/network/9606.ENSP00000342501Major facilitator superfamily domain-containing protein 2B; Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphin [...]
PYCR2 protein networkhttps://string-db.org/network/9606.ENSP00000342502Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation [...]
CEP97 protein networkhttps://string-db.org/network/9606.ENSP00000342510Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recru [...]
C3orf33 protein networkhttps://string-db.org/network/9606.ENSP00000342512Protein C3orf33; [Isoform 2]: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane.
IFI6 protein networkhttps://string-db.org/network/9606.ENSP00000342513Interferon alpha-inducible protein 6; Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to [...]
STMN4 protein networkhttps://string-db.org/network/9606.ENSP00000342538Stathmin-4; Exhibits microtubule-destabilizing activity.
HRH3 protein networkhttps://string-db.org/network/9606.ENSP00000342560Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and dis [...]
TREML4 protein networkhttps://string-db.org/network/9606.ENSP00000342570Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages.
FAM221A protein networkhttps://string-db.org/network/9606.ENSP00000342576Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family.
FAM184A protein networkhttps://string-db.org/network/9606.ENSP00000342604Protein FAM184A; Family with sequence similarity 184 member A.
ACER2 protein networkhttps://string-db.org/network/9606.ENSP00000342609Alkaline ceramidase 2; Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosp [...]
PDE4B protein networkhttps://string-db.org/network/9606.ENSP00000342637cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central ner [...]
AURKAIP1 protein networkhttps://string-db.org/network/9606.ENSP00000342676Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down- regulation through proteasome-dependent degradation.
EZHIP protein networkhttps://string-db.org/network/9606.ENSP00000342680EZH inhibitory protein; Inhibits PRC2/EED-EZH2 complex function thereby causing down- regulation of H3K27me3. In the PRC2/EED-EZH2 complex, interacts and inhibits EZH2 methyltransferase activity.
CD5 protein networkhttps://string-db.org/network/9606.ENSP00000342681T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation.
CFAP36 protein networkhttps://string-db.org/network/9606.ENSP00000342699Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family.
KRT77 protein networkhttps://string-db.org/network/9606.ENSP00000342710Keratin, type II cytoskeletal 1b; Keratin 77.
RNF41 protein networkhttps://string-db.org/network/9606.ENSP00000342755E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production o [...]
PPM1G protein networkhttps://string-db.org/network/9606.ENSP00000342778Protein phosphatase, Mg2+/Mn2+ dependent 1G.
FAM25A protein networkhttps://string-db.org/network/9606.ENSP00000342790Protein FAM25A; Family with sequence similarity 25 member A; Belongs to the FAM25 family.
PLD1 protein networkhttps://string-db.org/network/9606.ENSP00000342793Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulatio [...]
FAIM protein networkhttps://string-db.org/network/9606.ENSP00000342805Fas apoptotic inhibitory molecule 1; Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Belongs to the FAIM1 family.
USP9Y protein networkhttps://string-db.org/network/9606.ENSP00000342812Probable ubiquitin carboxyl-terminal hydrolase FAF-Y; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated p [...]
ZNF669 protein networkhttps://string-db.org/network/9606.ENSP00000342818Zinc finger protein 669; May be involved in transcriptional regulation.
NKX2-3 protein networkhttps://string-db.org/network/9606.ENSP00000342828Homeobox protein Nkx-2.3; Transcription factor; Belongs to the NK-2 homeobox family.
YPEL1 protein networkhttps://string-db.org/network/9606.ENSP00000342832Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Belongs to the yippee family.
OR6C74 protein networkhttps://string-db.org/network/9606.ENSP00000342836Olfactory receptor 6C74; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LYSMD4 protein networkhttps://string-db.org/network/9606.ENSP00000342840LysM and putative peptidoglycan-binding domain-containing protein 4; LysM domain containing 4.
NOXA1 protein networkhttps://string-db.org/network/9606.ENSP00000342848NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of [...]
SERPINA6 protein networkhttps://string-db.org/network/9606.ENSP00000342850Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
FERMT2 protein networkhttps://string-db.org/network/9606.ENSP00000342858Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosph [...]
POLR2K protein networkhttps://string-db.org/network/9606.ENSP00000342889DNA-directed RNA polymerases I, II, and III subunit RPABC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...]
MCPH1 protein networkhttps://string-db.org/network/9606.ENSP00000342924Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
POU1F1 protein networkhttps://string-db.org/network/9606.ENSP00000342931Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituita [...]
UPK3BL1 protein networkhttps://string-db.org/network/9606.ENSP00000342938Uroplakin-3b-like protein 1; Uroplakin 3B like 1.
ADCY2 protein networkhttps://string-db.org/network/9606.ENSP00000342952Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and [...]
SERINC1 protein networkhttps://string-db.org/network/9606.ENSP00000342962Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family.
ZNF791 protein networkhttps://string-db.org/network/9606.ENSP00000342974Zinc finger protein 791; May be involved in transcriptional regulation.
ADGRG5 protein networkhttps://string-db.org/network/9606.ENSP00000342981Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and [...]
UBE4B protein networkhttps://string-db.org/network/9606.ENSP00000343001Ubiquitin conjugation factor E4 B; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases (By similarity). May also function as an E4 liga [...]
B3GLCT protein networkhttps://string-db.org/network/9606.ENSP00000343002Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of protein [...]
SP100 protein networkhttps://string-db.org/network/9606.ENSP00000343023Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes includi [...]
RBM5 protein networkhttps://string-db.org/network/9606.ENSP00000343054RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to t [...]
GOLGA8B protein networkhttps://string-db.org/network/9606.ENSP00000343064Golgin subfamily A member 8B; May be involved in maintaining Golgi structure. Belongs to the GOLGA8 family.
PUS7L protein networkhttps://string-db.org/network/9606.ENSP00000343081Pseudouridylate synthase 7 homolog-like protein; Pseudouridylate synthase that catalyzes pseudouridylation of RNAs; Belongs to the pseudouridine synthase TruD family.
PRMT7 protein networkhttps://string-db.org/network/9606.ENSP00000343103Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a prefere [...]
LAMTOR4 protein networkhttps://string-db.org/network/9606.ENSP00000343118Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growt [...]
TRIM29 protein networkhttps://string-db.org/network/9606.ENSP00000343129Tripartite motif-containing protein 29; Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, [...]
XIRP1 protein networkhttps://string-db.org/network/9606.ENSP00000343140Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization. Belongs to the Xin family.
PARD6G protein networkhttps://string-db.org/network/9606.ENSP00000343144Partitioning defective 6 homolog gamma; Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The [...]
EPB41L3 protein networkhttps://string-db.org/network/9606.ENSP00000343158Band 4.1-like protein 3, N-terminally processed; Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, includ [...]
C2orf80 protein networkhttps://string-db.org/network/9606.ENSP00000343171Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80.
PRR27 protein networkhttps://string-db.org/network/9606.ENSP00000343172Proline-rich protein 27; Proline rich 27.
PPCDC protein networkhttps://string-db.org/network/9606.ENSP00000343190Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine; Belongs to [...]
SKOR1 protein networkhttps://string-db.org/network/9606.ENSP00000343200SKI family transcriptional corepressor 1.
LRRC69 protein networkhttps://string-db.org/network/9606.ENSP00000343221Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69.
TCL1B protein networkhttps://string-db.org/network/9606.ENSP00000343223T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2.
ZBED6CL protein networkhttps://string-db.org/network/9606.ENSP00000343242ZBED6 C-terminal-like protein; ZBED6 C-terminal like.
DUSP21 protein networkhttps://string-db.org/network/9606.ENSP00000343244Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphoth [...]
SBK1 protein networkhttps://string-db.org/network/9606.ENSP00000343248Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development; Belongs to the protein kinase superfamily. Ser/Thr protein kinas [...]
KLHL7 protein networkhttps://string-db.org/network/9606.ENSP00000343273Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substr [...]
FOXN3 protein networkhttps://string-db.org/network/9606.ENSP00000343288Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).
CFAP77 protein networkhttps://string-db.org/network/9606.ENSP00000343290Cilia and flagella associated protein 77.
PKN1 protein networkhttps://string-db.org/network/9606.ENSP00000343325Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migr [...]
LIPI protein networkhttps://string-db.org/network/9606.ENSP00000343331Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2- acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phosphol [...]
P2RX2 protein networkhttps://string-db.org/network/9606.ENSP00000343339P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) [...]
VMAC protein networkhttps://string-db.org/network/9606.ENSP00000343348Vimentin type intermediate filament associated coiled-coil protein.
VSTM1 protein networkhttps://string-db.org/network/9606.ENSP00000343366V-set and transmembrane domain-containing protein 1; [Isoform 2]: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-c [...]
CCDC18 protein networkhttps://string-db.org/network/9606.ENSP00000343377Coiled-coil domain containing 18.
TMPPE protein networkhttps://string-db.org/network/9606.ENSP00000343398Transmembrane protein with metallophosphoesterase domain.
SEC24C protein networkhttps://string-db.org/network/9606.ENSP00000343405Protein transport protein Sec24C; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
BABAM2 protein networkhttps://string-db.org/network/9606.ENSP00000343412BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to t [...]
GPR18 protein networkhttps://string-db.org/network/9606.ENSP00000343428N-arachidonyl glycine receptor; Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated [...]
YIF1B protein networkhttps://string-db.org/network/9606.ENSP00000343435Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein.
SERPINB4 protein networkhttps://string-db.org/network/9606.ENSP00000343445Serpin B4; May act as a protease inhibitor to modulate the host immune response against tumor cells.
NBR1 protein networkhttps://string-db.org/network/9606.ENSP00000343479Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
LCTL protein networkhttps://string-db.org/network/9606.ENSP00000343490Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho sub [...]
C17orf99 protein networkhttps://string-db.org/network/9606.ENSP00000343493Protein IL-40; Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production.
NOSIP protein networkhttps://string-db.org/network/9606.ENSP00000343497Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/thr [...]
TNFSF13 protein networkhttps://string-db.org/network/9606.ENSP00000343505Tumor necrosis factor ligand superfamily member 13; Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/ma [...]
TMEM198 protein networkhttps://string-db.org/network/9606.ENSP00000343507Transmembrane protein 198; Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 t [...]
TCEA2 protein networkhttps://string-db.org/network/9606.ENSP00000343515Transcription elongation factor A protein 2; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...]
OR1J4 protein networkhttps://string-db.org/network/9606.ENSP00000343521Olfactory receptor 1J4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
USP1 protein networkhttps://string-db.org/network/9606.ENSP00000343526Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis [...]
USP7 protein networkhttps://string-db.org/network/9606.ENSP00000343535Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents [...]
ICMT protein networkhttps://string-db.org/network/9606.ENSP00000343552Protein-S-isoprenylcysteine O-methyltransferase; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
TPSAB1 protein networkhttps://string-db.org/network/9606.ENSP00000343577Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate [...]
ZFP30 protein networkhttps://string-db.org/network/9606.ENSP00000343581Zinc finger protein 30 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF606 protein networkhttps://string-db.org/network/9606.ENSP00000343617Zinc finger protein 606; May act as a transcriptional repressor.
HOXA9 protein networkhttps://string-db.org/network/9606.ENSP00000343619Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PRRC2C protein networkhttps://string-db.org/network/9606.ENSP00000343629Protein PRRC2C; Proline rich coiled-coil 2C.
FOXN2 protein networkhttps://string-db.org/network/9606.ENSP00000343633Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR.
MEAK7 protein networkhttps://string-db.org/network/9606.ENSP00000343635MTOR-associated protein MEAK7; Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration. Recruits MTOR at the lysoso [...]
GFRAL protein networkhttps://string-db.org/network/9606.ENSP00000343636GDNF family receptor alpha-like; Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon [...]
RAPGEF5 protein networkhttps://string-db.org/network/9606.ENSP00000343656Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
MCCC2 protein networkhttps://string-db.org/network/9606.ENSP00000343657Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to [...]
MAP4K4 protein networkhttps://string-db.org/network/9606.ENSP00000343658Mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstr [...]
ASTL protein networkhttps://string-db.org/network/9606.ENSP00000343674Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease f [...]
GJA4 protein networkhttps://string-db.org/network/9606.ENSP00000343676Gap junction alpha-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
DPYSL3 protein networkhttps://string-db.org/network/9606.ENSP00000343690Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse a [...]
KPNA1 protein networkhttps://string-db.org/network/9606.ENSP00000343701Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing ei [...]
MAGEH1 protein networkhttps://string-db.org/network/9606.ENSP00000343706Melanoma-associated antigen H1; MAGE family member H1.
ATR protein networkhttps://string-db.org/network/9606.ENSP00000343741Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA r [...]
BROX protein networkhttps://string-db.org/network/9606.ENSP00000343742BRO1 domain-containing protein BROX; BRO1 domain and CAAX motif containing; Belongs to the BROX family.
CORO2A protein networkhttps://string-db.org/network/9606.ENSP00000343746Coronin-2A; Coronin 2A; Belongs to the WD repeat coronin family.
ADRB3 protein networkhttps://string-db.org/network/9606.ENSP00000343782Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of [...]
CDK5RAP2 protein networkhttps://string-db.org/network/9606.ENSP00000343818CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centr [...]
UGT1A10 protein networkhttps://string-db.org/network/9606.ENSP00000343838UDP-glucuronosyltransferase 1-10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...]
NEK10 protein networkhttps://string-db.org/network/9606.ENSP00000343847Serine/threonine-protein kinase Nek10; NIMA related kinase 10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.
MRRF protein networkhttps://string-db.org/network/9606.ENSP00000343867Ribosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by rec [...]
TMTC4 protein networkhttps://string-db.org/network/9606.ENSP00000343871Protein O-mannosyl-transferase TMTC4; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated pr [...]
PPA2 protein networkhttps://string-db.org/network/9606.ENSP00000343885Inorganic pyrophosphatase 2, mitochondrial; Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organizati [...]
CPTP protein networkhttps://string-db.org/network/9606.ENSP00000343890Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Go [...]
NLRP13 protein networkhttps://string-db.org/network/9606.ENSP00000343891NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation.
SMARCA4 protein networkhttps://string-db.org/network/9606.ENSP00000343896Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin [...]
FRMD6 protein networkhttps://string-db.org/network/9606.ENSP00000343899FERM domain containing 6.
CPSF4L protein networkhttps://string-db.org/network/9606.ENSP00000343900Putative cleavage and polyadenylation specificity factor subunit 4-like protein; Cleavage and polyadenylation specific factor 4 like; Belongs to the CPSF4/YTH1 family.
PRELP protein networkhttps://string-db.org/network/9606.ENSP00000343924Prolargin; May anchor basement membranes to the underlying connective tissue.
ESR2 protein networkhttps://string-db.org/network/9606.ENSP00000343925Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) [...]
KLHL17 protein networkhttps://string-db.org/network/9606.ENSP00000343930Kelch-like protein 17; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequen [...]
CCR6 protein networkhttps://string-db.org/network/9606.ENSP00000343952C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is [...]
IFNAR2 protein networkhttps://string-db.org/network/9606.ENSP00000343957Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activati [...]
PSPC1 protein networkhttps://string-db.org/network/9606.ENSP00000343966Paraspeckle component 1; Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and po [...]
OR2S2 protein networkhttps://string-db.org/network/9606.ENSP00000344040Olfactory receptor 2S2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SYNGR4 protein networkhttps://string-db.org/network/9606.ENSP00000344041Synaptogyrin-4; Synaptogyrin 4.
METTL24 protein networkhttps://string-db.org/network/9606.ENSP00000344071Methyltransferase-like protein 24; Methyltransferase like 24.
AUTS2 protein networkhttps://string-db.org/network/9606.ENSP00000344087Autism susceptibility gene 2 protein; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes [...]
POMGNT2 protein networkhttps://string-db.org/network/9606.ENSP00000344125Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the m [...]
ZNF648 protein networkhttps://string-db.org/network/9606.ENSP00000344129Zinc finger protein 648; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PPP1R32 protein networkhttps://string-db.org/network/9606.ENSP00000344140Protein phosphatase 1 regulatory subunit 32.
ABCA2 protein networkhttps://string-db.org/network/9606.ENSP00000344155ATP-binding cassette sub-family A member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.
ZNF136 protein networkhttps://string-db.org/network/9606.ENSP00000344162Zinc finger protein 136; May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain; Belongs t [...]
TMEM189-UBE2V1 protein networkhttps://string-db.org/network/9606.ENSP00000344166TMEM189-UBE2V1 readthrough.
TRIM14 protein networkhttps://string-db.org/network/9606.ENSP00000344208Tripartite motif-containing protein 14; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane [...]
TP53INP1 protein networkhttps://string-db.org/network/9606.ENSP00000344215Tumor protein p53-inducible nuclear protein 1; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a [...]
C1orf162 protein networkhttps://string-db.org/network/9606.ENSP00000344218Transmembrane protein C1orf162; Chromosome 1 open reading frame 162.
SUSD4 protein networkhttps://string-db.org/network/9606.ENSP00000344219Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bou [...]
PDPK1 protein networkhttps://string-db.org/network/9606.ENSP000003442203-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets i [...]
MBTPS1 protein networkhttps://string-db.org/network/9606.ENSP00000344223Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other [...]
LRRC43 protein networkhttps://string-db.org/network/9606.ENSP00000344233Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43.
ZMAT5 protein networkhttps://string-db.org/network/9606.ENSP00000344241Zinc finger matrin-type 5.
LRRC17 protein networkhttps://string-db.org/network/9606.ENSP00000344242Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similar [...]
GALNT15 protein networkhttps://string-db.org/network/9606.ENSP00000344260Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
BSX protein networkhttps://string-db.org/network/9606.ENSP00000344285Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal [...]
PTAR1 protein networkhttps://string-db.org/network/9606.ENSP00000344299Protein prenyltransferase alpha subunit repeat containing 1.
OFD1 protein networkhttps://string-db.org/network/9606.ENSP00000344314Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific prot [...]
DIPK1C protein networkhttps://string-db.org/network/9606.ENSP00000344331Divergent protein kinase domain 1C.
ATF3 protein networkhttps://string-db.org/network/9606.ENSP00000344352Cyclic AMP-dependent transcription factor ATF-3; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Re [...]
CLUAP1 protein networkhttps://string-db.org/network/9606.ENSP00000344392Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.
FCF1 protein networkhttps://string-db.org/network/9606.ENSP00000344393rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly; Belongs to the UTP23/FCF1 family. FCF1 subfamily.
LIN28B protein networkhttps://string-db.org/network/9606.ENSP00000344401Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including p [...]
TAS1R3 protein networkhttps://string-db.org/network/9606.ENSP00000344411Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synth [...]
KRTAP1-3 protein networkhttps://string-db.org/network/9606.ENSP00000344420Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
SUSD6 protein networkhttps://string-db.org/network/9606.ENSP00000344424Sushi domain-containing protein 6; May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUV [...]
IFITM10 protein networkhttps://string-db.org/network/9606.ENSP00000344430Interferon induced transmembrane protein 10.
DNAJB13 protein networkhttps://string-db.org/network/9606.ENSP00000344431DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes.
DOK7 protein networkhttps://string-db.org/network/9606.ENSP00000344432Protein Dok-7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor ( [...]
FGD6 protein networkhttps://string-db.org/network/9606.ENSP00000344446FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating [...]
PROZ protein networkhttps://string-db.org/network/9606.ENSP00000344458Vitamin K-dependent protein Z; Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa i [...]
PEAR1 protein networkhttps://string-db.org/network/9606.ENSP00000344465Platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells.
SDC3 protein networkhttps://string-db.org/network/9606.ENSP00000344468Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferrin [...]
NR4A2 protein networkhttps://string-db.org/network/9606.ENSP00000344479Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during develop [...]
JPH1 protein networkhttps://string-db.org/network/9606.ENSP00000344488Junctophilin-1; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...]
RNF133 protein networkhttps://string-db.org/network/9606.ENSP00000344489E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity.
TMEM201 protein networkhttps://string-db.org/network/9606.ENSP00000344503Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin-dependent nuclear movement via association with transmembran [...]
H1-0 protein networkhttps://string-db.org/network/9606.ENSP00000344504Histone H1.0, N-terminally processed; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal s [...]
IKZF3 protein networkhttps://string-db.org/network/9606.ENSP00000344544Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, pro [...]
SCGB1C1 protein networkhttps://string-db.org/network/9606.ENSP00000344545Secretoglobin family 1C member 1.
PTMA protein networkhttps://string-db.org/network/9606.ENSP00000344547Prothymosin alpha, N-terminally processed; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections; Belongs to the pro/parathymosin family.
CORO6 protein networkhttps://string-db.org/network/9606.ENSP00000344562Coronin-6; Coronin 6.
CLEC12B protein networkhttps://string-db.org/network/9606.ENSP00000344563C-type lectin domain family 12 member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphoryl [...]
FIBP protein networkhttps://string-db.org/network/9606.ENSP00000344572Acidic fibroblast growth factor intracellular-binding protein; May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo [...]
APOL3 protein networkhttps://string-db.org/network/9606.ENSP00000344577Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
FSCB protein networkhttps://string-db.org/network/9606.ENSP00000344579Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium.
BTG3 protein networkhttps://string-db.org/network/9606.ENSP00000344609Protein BTG3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
CCNG1 protein networkhttps://string-db.org/network/9606.ENSP00000344635Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular [...]
SLC37A1 protein networkhttps://string-db.org/network/9606.ENSP00000344648Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and transl [...]
NF2 protein networkhttps://string-db.org/network/9606.ENSP00000344666Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosi [...]
DHRS2 protein networkhttps://string-db.org/network/9606.ENSP00000344674Dehydrogenase/reductase SDR family member 2, mitochondrial; Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione a [...]
TOX2 protein networkhttps://string-db.org/network/9606.ENSP00000344724TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system.
FAM166A protein networkhttps://string-db.org/network/9606.ENSP00000344729Protein FAM166A; Family with sequence similarity 166 member A.
INSIG1 protein networkhttps://string-db.org/network/9606.ENSP00000344741Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding protein [...]
CFAP100 protein networkhttps://string-db.org/network/9606.ENSP00000344749Cilia- and flagella-associated protein 100; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.
ECM2 protein networkhttps://string-db.org/network/9606.ENSP00000344758Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness.
GFI1B protein networkhttps://string-db.org/network/9606.ENSP00000344782Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM [...]
NFASC protein networkhttps://string-db.org/network/9606.ENSP00000344786Neurofascin; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
ZNF600 protein networkhttps://string-db.org/network/9606.ENSP00000344791Zinc finger protein 600; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MOCS1 protein networkhttps://string-db.org/network/9606.ENSP00000344794Cyclic pyranopterin monophosphate synthase; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A c [...]
SLC24A2 protein networkhttps://string-db.org/network/9606.ENSP00000344801Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapi [...]
BSDC1 protein networkhttps://string-db.org/network/9606.ENSP00000344816BSD domain containing 1.
CMTM5 protein networkhttps://string-db.org/network/9606.ENSP00000344819CKLF like MARVEL transmembrane domain containing 5; Belongs to the chemokine-like factor family.
KCNK7 protein networkhttps://string-db.org/network/9606.ENSP00000344820Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as [...]
ZNF678 protein networkhttps://string-db.org/network/9606.ENSP00000344828Zinc finger protein 678; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
QPCT protein networkhttps://string-db.org/network/9606.ENSP00000344829Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue an [...]
SLC25A40 protein networkhttps://string-db.org/network/9606.ENSP00000344831Solute carrier family 25 member 40.
FBXL14 protein networkhttps://string-db.org/network/9606.ENSP00000344855F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitina [...]
IGFL3 protein networkhttps://string-db.org/network/9606.ENSP00000344860Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor.
C9orf153 protein networkhttps://string-db.org/network/9606.ENSP00000344865Uncharacterized protein C9orf153; Chromosome 9 open reading frame 153.
FBXL5 protein networkhttps://string-db.org/network/9606.ENSP00000344866F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradati [...]
MAFK protein networkhttps://string-db.org/network/9606.ENSP00000344903Transcription factor MafK; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they act as transcr [...]
CSTL1 protein networkhttps://string-db.org/network/9606.ENSP00000344907Cystatin like 1.
BPIFB6 protein networkhttps://string-db.org/network/9606.ENSP00000344929BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
DPY19L3 protein networkhttps://string-db.org/network/9606.ENSP00000344937Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family.
UNC119B protein networkhttps://string-db.org/network/9606.ENSP00000344942Protein unc-119 homolog B; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for t [...]
SPRY4 protein networkhttps://string-db.org/network/9606.ENSP00000344967Protein sprouty homolog 4; Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs [...]
DALRD3 protein networkhttps://string-db.org/network/9606.ENSP00000344989DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3.
PALM3 protein networkhttps://string-db.org/network/9606.ENSP00000344996Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling.
CRTC1 protein networkhttps://string-db.org/network/9606.ENSP00000345001CREB-regulated transcription coactivator 1; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...]
FBLN5 protein networkhttps://string-db.org/network/9606.ENSP00000345008Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes el [...]
GSTO2 protein networkhttps://string-db.org/network/9606.ENSP00000345023Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Pa [...]
GLI4 protein networkhttps://string-db.org/network/9606.ENSP00000345024GLI family zinc finger 4.
FAM47A protein networkhttps://string-db.org/network/9606.ENSP00000345029Protein FAM47A; Family with sequence similarity 47 member A.
KCNQ5 protein networkhttps://string-db.org/network/9606.ENSP00000345055Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium condu [...]
PRICKLE1 protein networkhttps://string-db.org/network/9606.ENSP00000345064Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogeneti [...]
MAP2K3 protein networkhttps://string-db.org/network/9606.ENSP00000345083Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a thr [...]
IMPDH1 protein networkhttps://string-db.org/network/9606.ENSP00000345096Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthe [...]
PEAK3 protein networkhttps://string-db.org/network/9606.ENSP00000345102Protein PEAK3; Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellip [...]
C2orf88 protein networkhttps://string-db.org/network/9606.ENSP00000345107Small membrane A-kinase anchor protein; Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane. Belongs to the small membrane AKAP fam [...]
CDC42BPG protein networkhttps://string-db.org/network/9606.ENSP00000345133Serine/threonine-protein kinase MRCK gamma; May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, throu [...]
NKX2-4 protein networkhttps://string-db.org/network/9606.ENSP00000345147Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family.
RFPL4AL1 protein networkhttps://string-db.org/network/9606.ENSP00000345151Ret finger protein like 4A like 1.
APOD protein networkhttps://string-db.org/network/9606.ENSP00000345179Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transp [...]
OLFM3 protein networkhttps://string-db.org/network/9606.ENSP00000345192Noelin-3; Olfactomedin 3.
SHANK2 protein networkhttps://string-db.org/network/9606.ENSP00000345193SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membran [...]
UBQLN2 protein networkhttps://string-db.org/network/9606.ENSP00000345195Ubiquilin-2; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticul [...]
RBPJ protein networkhttps://string-db.org/network/9606.ENSP00000345206Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates [...]
USP54 protein networkhttps://string-db.org/network/9606.ENSP00000345216Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family.
DNER protein networkhttps://string-db.org/network/9606.ENSP00000345229Delta and Notch-like epidermal growth factor-related receptor; Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
SIGLEC10 protein networkhttps://string-db.org/network/9606.ENSP00000345243Sialic acid-binding Ig-like lectin 10; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By simi [...]
EPB41 protein networkhttps://string-db.org/network/9606.ENSP00000345259Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformabili [...]
ZDHHC3 protein networkhttps://string-db.org/network/9606.ENSP00000345268Palmitoyltransferase ZDHHC3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/ [...]
MGAT3 protein networkhttps://string-db.org/network/9606.ENSP00000345270Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the [...]
GPT2 protein networkhttps://string-db.org/network/9606.ENSP00000345282Alanine aminotransferase 2; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Belongs to the class-I pyridoxal-phosphate-dependent aminotr [...]
NDRG3 protein networkhttps://string-db.org/network/9606.ENSP00000345292Protein NDRG3; NDRG family member 3; Belongs to the NDRG family.
SH2D4B protein networkhttps://string-db.org/network/9606.ENSP00000345295SH2 domain containing 4B.
ZNF69 protein networkhttps://string-db.org/network/9606.ENSP00000345333Zinc finger protein 69.
PTGES2 protein networkhttps://string-db.org/network/9606.ENSP00000345341Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
CTSL protein networkhttps://string-db.org/network/9606.ENSP00000345344Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subs [...]
HMGB1 protein networkhttps://string-db.org/network/9606.ENSP00000345347High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone [...]
PODXL2 protein networkhttps://string-db.org/network/9606.ENSP00000345359Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with [...]
ARPC5L protein networkhttps://string-db.org/network/9606.ENSP00000345361Actin-related protein 2/3 complex subunit 5-like protein; May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating n [...]
RTP5 protein networkhttps://string-db.org/network/9606.ENSP00000345374Receptor transporter protein 5.
PAPLN protein networkhttps://string-db.org/network/9606.ENSP00000345395Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family.
SPRED3 protein networkhttps://string-db.org/network/9606.ENSP00000345405Sprouty-related, EVH1 domain-containing protein 3; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase.
CPSF7 protein networkhttps://string-db.org/network/9606.ENSP00000345412Cleavage and polyadenylation specificity factor subunit 7; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation pr [...]
ASCL4 protein networkhttps://string-db.org/network/9606.ENSP00000345420Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development.
CASKIN1 protein networkhttps://string-db.org/network/9606.ENSP00000345436Caskin-1; May link the scaffolding protein CASK to downstream intracellular effectors.
SAMM50 protein networkhttps://string-db.org/network/9606.ENSP00000345445Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory cha [...]
NHLRC1 protein networkhttps://string-db.org/network/9606.ENSP00000345464E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates [...]
TMEM215 protein networkhttps://string-db.org/network/9606.ENSP00000345468Transmembrane protein 215.
CCDC38 protein networkhttps://string-db.org/network/9606.ENSP00000345470Coiled-coil domain containing 38.
ZNF587 protein networkhttps://string-db.org/network/9606.ENSP00000345479Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PCDHB13 protein networkhttps://string-db.org/network/9606.ENSP00000345491Protocadherin beta-13; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
SH2B3 protein networkhttps://string-db.org/network/9606.ENSP00000345492SH2B adapter protein 3; Links T-cell receptor activation signal to phospholipase C- gamma-1, GRB2 and phosphatidylinositol 3-kinase.
PLSCR1 protein networkhttps://string-db.org/network/9606.ENSP00000345494Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...]
PDE4D protein networkhttps://string-db.org/network/9606.ENSP00000345502cAMP-specific 3',5'-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
SLC35F6 protein networkhttps://string-db.org/network/9606.ENSP00000345528Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PD [...]
ENO4 protein networkhttps://string-db.org/network/9606.ENSP00000345555Enolase 4; May be required for sperm motility and function.
E2F1 protein networkhttps://string-db.org/network/9606.ENSP00000345571Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of gen [...]
DNAJB12 protein networkhttps://string-db.org/network/9606.ENSP00000345575DnaJ homolog subfamily B member 12; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded prot [...]
MAP3K15 protein networkhttps://string-db.org/network/9606.ENSP00000345629Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
ZCCHC13 protein networkhttps://string-db.org/network/9606.ENSP00000345633Zinc finger CCHC-type containing 13.
VAPA protein networkhttps://string-db.org/network/9606.ENSP00000345656Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in tu [...]
CA7 protein networkhttps://string-db.org/network/9606.ENSP00000345659Carbonic anhydrase 7; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family.
ILDR1 protein networkhttps://string-db.org/network/9606.ENSP00000345667Immunoglobulin-like domain-containing receptor 1; Putative membrane receptor.
CTSB protein networkhttps://string-db.org/network/9606.ENSP00000345672Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Cleaves matrix extracellular phosphoglycoprotein MEPE. Involved in [...]
GATA2 protein networkhttps://string-db.org/network/9606.ENSP00000345681Endothelial transcription factor GATA-2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'- AGATAG-3'.
NFYA protein networkhttps://string-db.org/network/9606.ENSP00000345702Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the prom [...]
KCNJ11 protein networkhttps://string-db.org/network/9606.ENSP00000345708ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to f [...]
NKAPL protein networkhttps://string-db.org/network/9606.ENSP00000345716NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.
TOR1A protein networkhttps://string-db.org/network/9606.ENSP00000345719Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Invo [...]
ATP7A protein networkhttps://string-db.org/network/9606.ENSP00000345728Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular co [...]
DLG1 protein networkhttps://string-db.org/network/9606.ENSP00000345731Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane [...]
SCNN1B protein networkhttps://string-db.org/network/9606.ENSP00000345751Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and w [...]
MTMR2 protein networkhttps://string-db.org/network/9606.ENSP00000345752Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-b [...]
ANKRD6 protein networkhttps://string-db.org/network/9606.ENSP00000345767Ankyrin repeat domain-containing protein 6; Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-c [...]
TEAD3 protein networkhttps://string-db.org/network/9606.ENSP00000345772Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...]
BEND7 protein networkhttps://string-db.org/network/9606.ENSP00000345773BEN domain containing 7.
ALDH3A2 protein networkhttps://string-db.org/network/9606.ENSP00000345774Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehyde [...]
FZD9 protein networkhttps://string-db.org/network/9606.ENSP00000345785Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulati [...]
ZC3H7B protein networkhttps://string-db.org/network/9606.ENSP00000345793Zinc finger CCCH domain-containing protein 7B; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apic [...]
KRBOX4 protein networkhttps://string-db.org/network/9606.ENSP00000345797KRAB box domain containing 4.
ARHGAP12 protein networkhttps://string-db.org/network/9606.ENSP00000345808Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
ZNF197 protein networkhttps://string-db.org/network/9606.ENSP00000345809Zinc finger protein 197; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TSPOAP1 protein networkhttps://string-db.org/network/9606.ENSP00000345824Peripheral-type benzodiazepine receptor-associated protein 1; TSPO associated protein 1; Belongs to the RIMBP family.
PMEPA1 protein networkhttps://string-db.org/network/9606.ENSP00000345826Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix product [...]
DPY30 protein networkhttps://string-db.org/network/9606.ENSP00000345837Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific t [...]
ANP32B protein networkhttps://string-db.org/network/9606.ENSP00000345848Acidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression f [...]
SPAM1 protein networkhttps://string-db.org/network/9606.ENSP00000345849Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus [...]
DUSP9 protein networkhttps://string-db.org/network/9606.ENSP00000345853Dual specificity protein phosphatase 9; Inactivates MAP kinases. Has a specificity for the ERK family; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity sub [...]
GJB4 protein networkhttps://string-db.org/network/9606.ENSP00000345868Gap junction beta-4 protein; Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the do [...]
SLC26A3 protein networkhttps://string-db.org/network/9606.ENSP00000345873Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bic [...]
NUP50 protein networkhttps://string-db.org/network/9606.ENSP00000345895Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembl [...]
LYAR protein networkhttps://string-db.org/network/9606.ENSP00000345917Cell growth-regulating nucleolar protein; Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and [...]
RPS21 protein networkhttps://string-db.org/network/9606.ENSP00000345957Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family.
FYB2 protein networkhttps://string-db.org/network/9606.ENSP00000345972FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion [...]
TRAF3IP2 protein networkhttps://string-db.org/network/9606.ENSP00000345984Adapter protein CIKS; Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress- activated protein kinase (SAPK)/JNK.
LRFN2 protein networkhttps://string-db.org/network/9606.ENSP00000345985Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 [...]
PLCH1 protein networkhttps://string-db.org/network/9606.ENSP000003459881-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calciu [...]
DMPK protein networkhttps://string-db.org/network/9606.ENSP00000345997Myotonin-protein kinase; Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation [...]
RPL3 protein networkhttps://string-db.org/network/9606.ENSP0000034600160S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
RPL36AL protein networkhttps://string-db.org/network/9606.ENSP00000346012Ribosomal protein L36a like; Belongs to the eukaryotic ribosomal protein eL42 family.
RPL27A protein networkhttps://string-db.org/network/9606.ENSP00000346015Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family.
RPL21 protein networkhttps://string-db.org/network/9606.ENSP0000034602760S ribosomal protein L21; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL21 family.
ANXA2 protein networkhttps://string-db.org/network/9606.ENSP00000346032Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in he [...]
RPLP1 protein networkhttps://string-db.org/network/9606.ENSP0000034603760S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.
RPS3A protein networkhttps://string-db.org/network/9606.ENSP0000034605040S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family.
TDRD6 protein networkhttps://string-db.org/network/9606.ENSP00000346065Tudor domain-containing protein 6; Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (du [...]
RPL22L1 protein networkhttps://string-db.org/network/9606.ENSP00000346080Ribosomal protein L22 like 1; Belongs to the eukaryotic ribosomal protein eL22 family.
RPL22 protein networkhttps://string-db.org/network/9606.ENSP00000346088Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family.
GPX4 protein networkhttps://string-db.org/network/9606.ENSP00000346103Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (B [...]
SLC12A6 protein networkhttps://string-db.org/network/9606.ENSP00000346112Solute carrier family 12 member 6; Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
DDX21 protein networkhttps://string-db.org/network/9606.ENSP00000346120Nucleolar RNA helicase 2; RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from p [...]
PLEKHB1 protein networkhttps://string-db.org/network/9606.ENSP00000346127Pleckstrin homology domain containing B1.
SVIP protein networkhttps://string-db.org/network/9606.ENSP00000346130Small VCP interacting protein; Belongs to the SVIP family.
TBC1D20 protein networkhttps://string-db.org/network/9606.ENSP00000346139TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of [...]
PRKAA1 protein networkhttps://string-db.org/network/9606.ENSP000003461485'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular e [...]
MAGI2 protein networkhttps://string-db.org/network/9606.ENSP00000346151Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion pr [...]
UCKL1 protein networkhttps://string-db.org/network/9606.ENSP00000346155Uridine-cytidine kinase-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation; Belongs to the uridine kinase family.
REG4 protein networkhttps://string-db.org/network/9606.ENSP00000346158Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be inv [...]
DUSP19 protein networkhttps://string-db.org/network/9606.ENSP00000346160Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins.
ETFB protein networkhttps://string-db.org/network/9606.ENSP00000346173Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glut [...]
SETDB2 protein networkhttps://string-db.org/network/9606.ENSP00000346175Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 ( [...]
NDUFV3 protein networkhttps://string-db.org/network/9606.ENSP00000346196NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...]
TAP1 protein networkhttps://string-db.org/network/9606.ENSP00000346206Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold [...]
FBXO2 protein networkhttps://string-db.org/network/9606.ENSP00000346240F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradatio [...]
BPIFA1 protein networkhttps://string-db.org/network/9606.ENSP00000346251BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune [...]
PPTC7 protein networkhttps://string-db.org/network/9606.ENSP00000346255Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is lik [...]
SYT5 protein networkhttps://string-db.org/network/9606.ENSP00000346265Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...]
PRAMEF20 protein networkhttps://string-db.org/network/9606.ENSP00000346275PRAME family member 20; Belongs to the PRAME family.
HRCT1 protein networkhttps://string-db.org/network/9606.ENSP00000346283Histidine rich carboxyl terminus 1.
SLC6A20 protein networkhttps://string-db.org/network/9606.ENSP00000346298Sodium- and chloride-dependent transporter XTRP3; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. In [...]
CRKL protein networkhttps://string-db.org/network/9606.ENSP00000346300Crk-like protein; May mediate the transduction of intracellular signals.
NRDE2 protein networkhttps://string-db.org/network/9606.ENSP00000346335Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing variou [...]
COPS8 protein networkhttps://string-db.org/network/9606.ENSP00000346340COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
RFPL1 protein networkhttps://string-db.org/network/9606.ENSP00000346342Ret finger protein-like 1; Negatively regulates the G2-M phase transition, possibly by promoting cyclin B1/CCNB1 and CDK1 proteasomal degradation and thereby preventing their accumulation during [...]
ZNF774 protein networkhttps://string-db.org/network/9606.ENSP00000346348Zinc finger protein 774; May be involved in transcriptional regulation.
KIAA0586 protein networkhttps://string-db.org/network/9606.ENSP00000346359Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes [...]
APBB3 protein networkhttps://string-db.org/network/9606.ENSP00000346378Amyloid-beta A4 precursor protein-binding family B member 3; May modulate the internalization of amyloid-beta precursor protein.
FAM78B protein networkhttps://string-db.org/network/9606.ENSP00000346404Protein FAM78B; Family with sequence similarity 78 member B; Belongs to the FAM78 family.
LRRIQ3 protein networkhttps://string-db.org/network/9606.ENSP00000346414Leucine rich repeats and IQ motif containing 3.
ATG7 protein networkhttps://string-db.org/network/9606.ENSP00000346437Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 [...]
LRMP protein networkhttps://string-db.org/network/9606.ENSP00000346442Processed lymphoid-restricted membrane protein; Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with [...]
IPO4 protein networkhttps://string-db.org/network/9606.ENSP00000346453Importin-4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...]
VPS72 protein networkhttps://string-db.org/network/9606.ENSP00000346464Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component [...]
WDR91 protein networkhttps://string-db.org/network/9606.ENSP00000346466WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying [...]
ADAMTSL2 protein networkhttps://string-db.org/network/9606.ENSP00000346478ADAMTS-like protein 2; ADAMTS like 2.
DDRGK1 protein networkhttps://string-db.org/network/9606.ENSP00000346483DDRGK domain-containing protein 1; Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may [...]
MAK protein networkhttps://string-db.org/network/9606.ENSP00000346484Serine/threonine-protein kinase MAK; Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle- [...]
PDGFA protein networkhttps://string-db.org/network/9606.ENSP00000346508Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Poten [...]
H2AB2 protein networkhttps://string-db.org/network/9606.ENSP00000346509Histone H2A-Bbd type 2/3; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact [...]
SCN8A protein networkhttps://string-db.org/network/9606.ENSP00000346534Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
KRTAP23-1 protein networkhttps://string-db.org/network/9606.ENSP00000346536Keratin-associated protein 23-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
SMOC2 protein networkhttps://string-db.org/network/9606.ENSP00000346537SPARC-related modular calcium-binding protein 2; Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
ANXA6 protein networkhttps://string-db.org/network/9606.ENSP00000346550Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family.
FILIP1L protein networkhttps://string-db.org/network/9606.ENSP00000346560Filamin A-interacting protein 1-like; Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation a [...]
AK5 protein networkhttps://string-db.org/network/9606.ENSP00000346577Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Act [...]
STYX protein networkhttps://string-db.org/network/9606.ENSP00000346599Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatio [...]
ZBTB45 protein networkhttps://string-db.org/network/9606.ENSP00000346603Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By simila [...]
TYW5 protein networkhttps://string-db.org/network/9606.ENSP00000346627tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at t [...]
THRAP3 protein networkhttps://string-db.org/network/9606.ENSP00000346634Thyroid hormone receptor-associated protein 3; Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction compl [...]
ERO1B protein networkhttps://string-db.org/network/9606.ENSP00000346635ERO1-like protein beta; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in or [...]
HKDC1 protein networkhttps://string-db.org/network/9606.ENSP00000346643Hexokinase HKDC1; Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to ot [...]
OCA2 protein networkhttps://string-db.org/network/9606.ENSP00000346659P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the comp [...]
WNK3 protein networkhttps://string-db.org/network/9606.ENSP00000346667Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an ac [...]
FYN protein networkhttps://string-db.org/network/9606.ENSP00000346671Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated [...]
ELOVL2 protein networkhttps://string-db.org/network/9606.ENSP00000346693Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
HNRNPA2B1 protein networkhttps://string-db.org/network/9606.ENSP00000346694Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arr [...]
BMF protein networkhttps://string-db.org/network/9606.ENSP00000346697Bcl-2-modifying factor; May play a role in apoptosis. Isoform 1 seems to be the main initiator.
PES1 protein networkhttps://string-db.org/network/9606.ENSP00000346725Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family.
ZNF589 protein networkhttps://string-db.org/network/9606.ENSP00000346729Zinc finger protein 589; May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor; Belongs to the krueppel C2H2- [...]
ACAP3 protein networkhttps://string-db.org/network/9606.ENSP00000346733Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family.
SND1 protein networkhttps://string-db.org/network/9606.ENSP00000346762Staphylococcal nuclease domain-containing protein 1; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs in [...]
UGT1A9 protein networkhttps://string-db.org/network/9606.ENSP00000346768UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity [...]
PCDHB11 protein networkhttps://string-db.org/network/9606.ENSP00000346802Protocadherin beta-11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
CRYBA4 protein networkhttps://string-db.org/network/9606.ENSP00000346805Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
PGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000346809GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic re [...]
ALDH9A1 protein networkhttps://string-db.org/network/9606.ENSP000003468274-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irrever [...]
WLS protein networkhttps://string-db.org/network/9606.ENSP00000346829Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular [...]
FN1 protein networkhttps://string-db.org/network/9606.ENSP00000346839Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wo [...]
FAR1 protein networkhttps://string-db.org/network/9606.ENSP00000346874Fatty acyl-CoA reductase 1; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalo [...]
NKX2-1 protein networkhttps://string-db.org/network/9606.ENSP00000346879Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the mai [...]
GABPA protein networkhttps://string-db.org/network/9606.ENSP00000346886GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Belongs to the ETS famil [...]
NRDC protein networkhttps://string-db.org/network/9606.ENSP00000346890Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs; Belongs to the peptidase M16 family.
SERF1A protein networkhttps://string-db.org/network/9606.ENSP00000346892Small EDRK-rich factor 1; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into c [...]
FMO1 protein networkhttps://string-db.org/network/9606.ENSP00000346901Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenatio [...]
TRIM6-TRIM34 protein networkhttps://string-db.org/network/9606.ENSP00000346916Tripartite motif-containing protein 34; May function as antiviral protein and may contribute to the defense against retroviral infections; Belongs to the TRIM/RBCC family.
NAA80 protein networkhttps://string-db.org/network/9606.ENSP00000346927N-alpha-acetyltransferase 80; N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respect [...]
C6orf120 protein networkhttps://string-db.org/network/9606.ENSP00000346931UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
TMEM205 protein networkhttps://string-db.org/network/9606.ENSP00000346954Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
SLC25A26 protein networkhttps://string-db.org/network/9606.ENSP00000346955S-adenosylmethionine mitochondrial carrier protein; Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates t [...]
SLC38A6 protein networkhttps://string-db.org/network/9606.ENSP00000346959Probable sodium-coupled neutral amino acid transporter 6; Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate.
EGFLAM protein networkhttps://string-db.org/network/9606.ENSP00000346964Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the phot [...]
TMEM207 protein networkhttps://string-db.org/network/9606.ENSP00000346981Transmembrane protein 207.
WAC protein networkhttps://string-db.org/network/9606.ENSP00000346986WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase [...]
SCARA5 protein networkhttps://string-db.org/network/9606.ENSP00000346990Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosi [...]
SUV39H2 protein networkhttps://string-db.org/network/9606.ENSP00000346997Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation [...]
OR5K4 protein networkhttps://string-db.org/network/9606.ENSP00000347003Olfactory receptor 5K4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LUC7L2 protein networkhttps://string-db.org/network/9606.ENSP00000347005Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain.
PIP4K2C protein networkhttps://string-db.org/network/9606.ENSP00000347032Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.
PLSCR4 protein networkhttps://string-db.org/network/9606.ENSP00000347038Phospholipid scramblase 4; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...]
FMOD protein networkhttps://string-db.org/network/9606.ENSP00000347041Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class [...]
ZNF649 protein networkhttps://string-db.org/network/9606.ENSP00000347043Zinc finger protein 649; Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathwa [...]
PDE5A protein networkhttps://string-db.org/network/9606.ENSP00000347046cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specifi [...]
MYL4 protein networkhttps://string-db.org/network/9606.ENSP00000347055Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium.
LARGE1 protein networkhttps://string-db.org/network/9606.ENSP00000347088LARGE xylosyl- and glucuronyltransferase 1; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phospho [...]
H2BW2 protein networkhttps://string-db.org/network/9606.ENSP00000347119Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
NET1 protein networkhttps://string-db.org/network/9606.ENSP00000347134Neuroepithelial cell-transforming gene 1 protein; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stre [...]
ASGR2 protein networkhttps://string-db.org/network/9606.ENSP00000347140Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor rec [...]
ATRNL1 protein networkhttps://string-db.org/network/9606.ENSP00000347152Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis.
H4C11 protein networkhttps://string-db.org/network/9606.ENSP00000347168H4 clustered histone 11.
NEIL1 protein networkhttps://string-db.org/network/9606.ENSP00000347170Endonuclease 8-like 1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for [...]
HTT protein networkhttps://string-db.org/network/9606.ENSP00000347184Huntingtin, myristoylated N-terminal fragment; [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function.
KCTD6 protein networkhttps://string-db.org/network/9606.ENSP00000347188BTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal d [...]
KLHL28 protein networkhttps://string-db.org/network/9606.ENSP00000347193Kelch-like protein 28; Kelch like family member 28.
STIMATE protein networkhttps://string-db.org/network/9606.ENSP00000347195Store-operated calcium entry regulator STIMATE; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), [...]
C5AR1 protein networkhttps://string-db.org/network/9606.ENSP00000347197C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high- affinity s [...]
SRGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000347198SLIT-ROBO Rho GTPase-activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of [...]
GPAA1 protein networkhttps://string-db.org/network/9606.ENSP00000347206Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate [...]
ENTPD2 protein networkhttps://string-db.org/network/9606.ENSP00000347213Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal exte [...]
GPBP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000347224Vasculin-like protein 1; Possible transcription factor.
BLM protein networkhttps://string-db.org/network/9606.ENSP00000347232Bloom syndrome protein; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of [...]
ITSN2 protein networkhttps://string-db.org/network/9606.ENSP00000347244Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs [...]
MRPL52 protein networkhttps://string-db.org/network/9606.ENSP00000347277Mitochondrial ribosomal protein L52.
C6orf89 protein networkhttps://string-db.org/network/9606.ENSP00000347322Bombesin receptor-activated protein C6orf89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells.
MSRB3 protein networkhttps://string-db.org/network/9606.ENSP00000347324Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
ZNF607 protein networkhttps://string-db.org/network/9606.ENSP00000347338Zinc finger protein 607; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
POLR3H protein networkhttps://string-db.org/network/9606.ENSP00000347345DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
MAGEA11 protein networkhttps://string-db.org/network/9606.ENSP00000347358Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal d [...]
OCLN protein networkhttps://string-db.org/network/9606.ENSP00000347379Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctio [...]
AP3M1 protein networkhttps://string-db.org/network/9606.ENSP00000347408AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral struct [...]
KEL protein networkhttps://string-db.org/network/9606.ENSP00000347409Kell blood group glycoprotein; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
OR5H2 protein networkhttps://string-db.org/network/9606.ENSP00000347418Olfactory receptor 5H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MINK1 protein networkhttps://string-db.org/network/9606.ENSP00000347427Misshapen-like kinase 1; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. R [...]
OR2L5 protein networkhttps://string-db.org/network/9606.ENSP00000347428Olfactory receptor 2L5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
APCDD1 protein networkhttps://string-db.org/network/9606.ENSP00000347433Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt a [...]
TDRD7 protein networkhttps://string-db.org/network/9606.ENSP00000347444Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and reg [...]
LINGO1 protein networkhttps://string-db.org/network/9606.ENSP00000347451Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation resp [...]
ANO1 protein networkhttps://string-db.org/network/9606.ENSP00000347454Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial [...]
DNM3 protein networkhttps://string-db.org/network/9606.ENSP00000347457Dynamin-3; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, [...]
GIT2 protein networkhttps://string-db.org/network/9606.ENSP00000347464ARF GTPase-activating protein GIT2; GTPase-activating protein for the ADP ribosylation factor family.
THSD4 protein networkhttps://string-db.org/network/9606.ENSP00000347484Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active [...]
MORN3 protein networkhttps://string-db.org/network/9606.ENSP00000347486MORN repeat containing 3.
WARS1 protein networkhttps://string-db.org/network/9606.ENSP00000347495Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas [...]
ZFYVE19 protein networkhttps://string-db.org/network/9606.ENSP00000347498Abscission/NoCut checkpoint regulator; Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolu [...]
MYH7 protein networkhttps://string-db.org/network/9606.ENSP00000347507Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute [...]
SHTN1 protein networkhttps://string-db.org/network/9606.ENSP00000347532Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch enga [...]
SYT17 protein networkhttps://string-db.org/network/9606.ENSP00000347538Synaptotagmin-17; Plays a role in dendrite formation by melanocytes ; Belongs to the synaptotagmin family.
RNF220 protein networkhttps://string-db.org/network/9606.ENSP00000347548E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, act [...]
MFSD12 protein networkhttps://string-db.org/network/9606.ENSP00000347583Major facilitator superfamily domain containing 12.
CCDC69 protein networkhttps://string-db.org/network/9606.ENSP00000347586Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spin [...]
GFRA1 protein networkhttps://string-db.org/network/9606.ENSP00000347591GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).
ARID4A protein networkhttps://string-db.org/network/9606.ENSP00000347602AT-rich interactive domain-containing protein 4A; DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen [...]
NUDCD3 protein networkhttps://string-db.org/network/9606.ENSP00000347626NudC domain containing 3.
KRTAP13-1 protein networkhttps://string-db.org/network/9606.ENSP00000347635Keratin-associated protein 13-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
SOX12 protein networkhttps://string-db.org/network/9606.ENSP00000347646Transcription factor SOX-12; Binds to the sequence 5'-AACAAT-3'.
ZNF512 protein networkhttps://string-db.org/network/9606.ENSP00000347648Zinc finger protein 512; May be involved in transcriptional regulation.
P3H4 protein networkhttps://string-db.org/network/9606.ENSP00000347649Endoplasmic reticulum protein SC65; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly [...]
GRK6 protein networkhttps://string-db.org/network/9606.ENSP00000347655G protein-coupled receptor kinase 6; Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor dese [...]
VANGL1 protein networkhttps://string-db.org/network/9606.ENSP00000347672VANGL planar cell polarity protein 1.
LMX1B protein networkhttps://string-db.org/network/9606.ENSP00000347684LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
PDE4C-2 protein networkhttps://string-db.org/network/9606.ENSP00000347689cAMP-specific 3',5'-cyclic phosphodiesterase 4C; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phospho [...]
OPHN1 protein networkhttps://string-db.org/network/9606.ENSP00000347710Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in s [...]
C2CD4A protein networkhttps://string-db.org/network/9606.ENSP00000347712C2 calcium-dependent domain-containing protein 4A; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family.
FCAR protein networkhttps://string-db.org/network/9606.ENSP00000347714Immunoglobulin alpha Fc receptor; Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
DPF1 protein networkhttps://string-db.org/network/9606.ENSP00000347716Zinc finger protein neuro-d4; May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the ne [...]
DHCR7 protein networkhttps://string-db.org/network/9606.ENSP000003477177-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family.
TBCD protein networkhttps://string-db.org/network/9606.ENSP00000347719Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtub [...]
SPNS3 protein networkhttps://string-db.org/network/9606.ENSP00000347721Protein spinster homolog 3; Sphingolipid transporter.
ZNF536 protein networkhttps://string-db.org/network/9606.ENSP00000347730Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3'; Belongs to the krueppel C2H2-type zinc-finger protein [...]
PDZD3 protein networkhttps://string-db.org/network/9606.ENSP00000347742Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9 [...]
HTR3A protein networkhttps://string-db.org/network/9606.ENSP000003477545-hydroxytryptamine receptor 3A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
ZNF140 protein networkhttps://string-db.org/network/9606.ENSP00000347755Zinc finger protein 140; May be involved in transcriptional regulation as a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family.
NEK5 protein networkhttps://string-db.org/network/9606.ENSP00000347767Serine/threonine-protein kinase Nek5; NIMA related kinase 5.
SLC26A8 protein networkhttps://string-db.org/network/9606.ENSP00000347778Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meio [...]
SYNJ2 protein networkhttps://string-db.org/network/9606.ENSP00000347792Synaptojanin-2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis; Belongs t [...]
ANKRD35 protein networkhttps://string-db.org/network/9606.ENSP00000347802Ankyrin repeat domain 35.
DEFB107B protein networkhttps://string-db.org/network/9606.ENSP00000347810Defensin beta 107B.
MORC4 protein networkhttps://string-db.org/network/9606.ENSP00000347821MORC family CW-type zinc finger 4.
KRT39 protein networkhttps://string-db.org/network/9606.ENSP00000347823Keratin, type I cytoskeletal 39; May play a role in late hair differentiation.
FBXL3 protein networkhttps://string-db.org/network/9606.ENSP00000347834F-box/LRR-repeat protein 3; Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the sp [...]
UBE2H protein networkhttps://string-db.org/network/9606.ENSP00000347836Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, [...]
TASOR protein networkhttps://string-db.org/network/9606.ENSP00000347845Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain [...]
SORBS2 protein networkhttps://string-db.org/network/9606.ENSP00000347852Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex w [...]
VAT1 protein networkhttps://string-db.org/network/9606.ENSP00000347872Synaptic vesicle membrane protein VAT-1 homolog; Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect [...]
MBD6 protein networkhttps://string-db.org/network/9606.ENSP00000347896Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
TTC30A protein networkhttps://string-db.org/network/9606.ENSP00000347915Tetratricopeptide repeat protein 30A; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are tra [...]
CLEC12A protein networkhttps://string-db.org/network/9606.ENSP00000347916C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
SFXN4 protein networkhttps://string-db.org/network/9606.ENSP00000347924Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria. Belongs to the sideroflexin [...]
PCNX3 protein networkhttps://string-db.org/network/9606.ENSP00000347931Pecanex-like protein 3; Pecanex 3; Belongs to the pecanex family.
PLGLB1 protein networkhttps://string-db.org/network/9606.ENSP00000347933Plasminogen-like protein B; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin t [...]
RET protein networkhttps://string-db.org/network/9606.ENSP00000347942Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, ce [...]
TNFRSF14 protein networkhttps://string-db.org/network/9606.ENSP00000347948Tumor necrosis factor receptor superfamily member 14; Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin s [...]
UBQLN3 protein networkhttps://string-db.org/network/9606.ENSP00000347997Ubiquilin-3; Ubiquilin 3.
PRPF39 protein networkhttps://string-db.org/network/9606.ENSP00000348010Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing.
SLC17A5 protein networkhttps://string-db.org/network/9606.ENSP00000348019Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Medi [...]
MLH3 protein networkhttps://string-db.org/network/9606.ENSP00000348020DNA mismatch repair protein Mlh3; Probably involved in the repair of mismatches in DNA.
OR11L1 protein networkhttps://string-db.org/network/9606.ENSP00000348033Olfactory receptor 11L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LRRC20 protein networkhttps://string-db.org/network/9606.ENSP00000348043Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20.
COMMD6 protein networkhttps://string-db.org/network/9606.ENSP00000348054COMM domain-containing protein 6; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF- kappa-B. Inhibits TNF-induced NFKB1 activation.
UBE2I protein networkhttps://string-db.org/network/9606.ENSP00000348056SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3, SUMO4 and SUMO1P1/SUMO5 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other p [...]
ART3 protein networkhttps://string-db.org/network/9606.ENSP00000348064ADP-ribosyltransferase 3.
SREBF1 protein networkhttps://string-db.org/network/9606.ENSP00000348069Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to [...]
CLEC9A protein networkhttps://string-db.org/network/9606.ENSP00000348074C-type lectin domain family 9 member A; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes fil [...]
FAM227A protein networkhttps://string-db.org/network/9606.ENSP00000348086Protein FAM227A; Family with sequence similarity 227 member A.
ERCC6 protein networkhttps://string-db.org/network/9606.ENSP00000348089DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the tr [...]
PDLIM7 protein networkhttps://string-db.org/network/9606.ENSP00000348099PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding pro [...]
C1D protein networkhttps://string-db.org/network/9606.ENSP00000348107Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MP [...]
KHDRBS3 protein networkhttps://string-db.org/network/9606.ENSP00000348108KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site select [...]
SVIL protein networkhttps://string-db.org/network/9606.ENSP00000348128Supervillin; [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to my [...]
WDR88 protein networkhttps://string-db.org/network/9606.ENSP00000348129WD repeat domain 88.
STK31 protein networkhttps://string-db.org/network/9606.ENSP00000348132Serine/threonine kinase 31; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
C14orf178 protein networkhttps://string-db.org/network/9606.ENSP00000348145Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178.
GPR160 protein networkhttps://string-db.org/network/9606.ENSP00000348161Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF507 protein networkhttps://string-db.org/network/9606.ENSP00000348162Zinc finger protein 507; May be involved in transcriptional regulation.
PLS3 protein networkhttps://string-db.org/network/9606.ENSP00000348163Plastin-3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development.
GTF2E2 protein networkhttps://string-db.org/network/9606.ENSP00000348168Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFI [...]
NLGN4Y protein networkhttps://string-db.org/network/9606.ENSP00000348169Neuroligin-4, Y-linked; Putative neuronal cell surface protein involved in cell-cell- interactions.
HP protein networkhttps://string-db.org/network/9606.ENSP00000348170Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to [...]
PRELID3B protein networkhttps://string-db.org/network/9606.ENSP00000348206PRELI domain containing 3B.
SLC25A46 protein networkhttps://string-db.org/network/9606.ENSP00000348211Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family.
SH3PXD2A protein networkhttps://string-db.org/network/9606.ENSP00000348215SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metal [...]
TRIM4 protein networkhttps://string-db.org/network/9606.ENSP00000348216E3 ubiquitin-protein ligase TRIM4; E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradati [...]
TAT protein networkhttps://string-db.org/network/9606.ENSP00000348234Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate a [...]
STK39 protein networkhttps://string-db.org/network/9606.ENSP00000348278STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffol [...]
TRIM13 protein networkhttps://string-db.org/network/9606.ENSP00000348299E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a [...]
BTG4 protein networkhttps://string-db.org/network/9606.ENSP00000348300Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest.
MMP23B protein networkhttps://string-db.org/network/9606.ENSP00000348308Matrix metalloproteinase-23, soluble form; Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity).
SPEF2 protein networkhttps://string-db.org/network/9606.ENSP00000348314Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Play [...]
JPT1 protein networkhttps://string-db.org/network/9606.ENSP00000348316Jupiter microtubule associated homolog 1, N-terminally processed; Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppressio [...]
MYO9A protein networkhttps://string-db.org/network/9606.ENSP00000348349Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity [...]
CYP20A1 protein networkhttps://string-db.org/network/9606.ENSP00000348380Cytochrome P450 family 20 subfamily A member 1.
ADD3 protein networkhttps://string-db.org/network/9606.ENSP00000348381Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. Belongs to the aldol [...]
COL27A1 protein networkhttps://string-db.org/network/9606.ENSP00000348385Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone; Belongs to the fibrillar collagen family.
NPEPL1 protein networkhttps://string-db.org/network/9606.ENSP00000348395Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
TJP1 protein networkhttps://string-db.org/network/9606.ENSP00000348416Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, an [...]
ZNF44 protein networkhttps://string-db.org/network/9606.ENSP00000348419Zinc finger protein 44; May be involved in transcriptional regulation.
ACSL5 protein networkhttps://string-db.org/network/9606.ENSP00000348429Long-chain-fatty-acid--CoA ligase 5; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. A [...]
PSMD12 protein networkhttps://string-db.org/network/9606.ENSP0000034844226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...]
OR8B4 protein networkhttps://string-db.org/network/9606.ENSP00000348449Olfactory receptor 8B4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ANO2 protein networkhttps://string-db.org/network/9606.ENSP00000348453Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in [...]
UVRAG protein networkhttps://string-db.org/network/9606.ENSP00000348455UV radiation resistance-associated gene protein; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the [...]
ACMSD protein networkhttps://string-db.org/network/9606.ENSP000003484592-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non [...]
NPAS3 protein networkhttps://string-db.org/network/9606.ENSP00000348460Neuronal PAS domain-containing protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity).
RAC1 protein networkhttps://string-db.org/network/9606.ENSP00000348461Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of [...]
SH3YL1 protein networkhttps://string-db.org/network/9606.ENSP00000348471SH3 domain-containing YSC84-like protein 1; SH3 and SYLF domain containing 1.
PXK protein networkhttps://string-db.org/network/9606.ENSP00000348472PX domain-containing protein kinase-like protein; Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and [...]
FBRS protein networkhttps://string-db.org/network/9606.ENSP00000348489Probable fibrosin-1; Fibrosin.
SUN5 protein networkhttps://string-db.org/network/9606.ENSP00000348496SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
GTF3C1 protein networkhttps://string-db.org/network/9606.ENSP00000348510General transcription factor 3C polypeptide 1; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required fo [...]
CENPL protein networkhttps://string-db.org/network/9606.ENSP00000348527Centromere protein L; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
RBM38 protein networkhttps://string-db.org/network/9606.ENSP00000348538RNA-binding protein 38; RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p [...]
CDC16 protein networkhttps://string-db.org/network/9606.ENSP00000348554Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
CDAN1 protein networkhttps://string-db.org/network/9606.ENSP00000348564Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly.
UBA5 protein networkhttps://string-db.org/network/9606.ENSP00000348565Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2. Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
AKAP9 protein networkhttps://string-db.org/network/9606.ENSP00000348573A-kinase anchor protein 9; Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi appar [...]
SDAD1 protein networkhttps://string-db.org/network/9606.ENSP00000348596Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.
AMPH protein networkhttps://string-db.org/network/9606.ENSP00000348602Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton.
RBCK1 protein networkhttps://string-db.org/network/9606.ENSP00000348632RanBP-type and C3HC4-type zinc finger-containing protein 1; E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then tra [...]
JAML protein networkhttps://string-db.org/network/9606.ENSP00000348635Junctional adhesion molecule-like; Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane recepto [...]
TMPRSS11F protein networkhttps://string-db.org/network/9606.ENSP00000348639Transmembrane protease serine 11F; Probable serine protease; Belongs to the peptidase S1 family.
PXDNL protein networkhttps://string-db.org/network/9606.ENSP00000348645Peroxidasin-like protein; [Isoform PMR1]: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs.
GALNT6 protein networkhttps://string-db.org/network/9606.ENSP00000348668Polypeptide N-acetylgalactosaminyltransferase 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threon [...]
ZNF770 protein networkhttps://string-db.org/network/9606.ENSP00000348673Zinc finger protein 770; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
UPF2 protein networkhttps://string-db.org/network/9606.ENSP00000348708Regulator of nonsense transcripts 2; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by [...]
AREL1 protein networkhttps://string-db.org/network/9606.ENSP00000348714Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfe [...]
ORAI2 protein networkhttps://string-db.org/network/9606.ENSP00000348752Protein orai-2; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
SPRED2 protein networkhttps://string-db.org/network/9606.ENSP00000348753Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.
CCDC151 protein networkhttps://string-db.org/network/9606.ENSP00000348757Coiled-coil domain-containing protein 151; Ciliary protein involved in outer dynein arm assembly and required for motile cilia function.
ARIH2 protein networkhttps://string-db.org/network/9606.ENSP00000348769E3 ubiquitin-protein ligase ARIH2; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiq [...]
PITPNM1 protein networkhttps://string-db.org/network/9606.ENSP00000348772Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in [...]
ACOX3 protein networkhttps://string-db.org/network/9606.ENSP00000348775Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids. Belongs to the acyl-CoA oxidase family.
MYOM1 protein networkhttps://string-db.org/network/9606.ENSP00000348821Myomesin-1; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
ARHGEF26 protein networkhttps://string-db.org/network/9606.ENSP00000348828Rho guanine nucleotide exchange factor 26; Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the [...]
UBE2C protein networkhttps://string-db.org/network/9606.ENSP00000348838Ubiquitin-conjugating enzyme E2 C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitinati [...]
EML6 protein networkhttps://string-db.org/network/9606.ENSP00000348842Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
WDR45 protein networkhttps://string-db.org/network/9606.ENSP00000348848WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged [...]
RPS26 protein networkhttps://string-db.org/network/9606.ENSP00000348849Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.
STOML2 protein networkhttps://string-db.org/network/9606.ENSP00000348886Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enric [...]
PIGR protein networkhttps://string-db.org/network/9606.ENSP00000348888Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the [...]
AADACL2 protein networkhttps://string-db.org/network/9606.ENSP00000348911Arylacetamide deacetylase like 2.
ADAM33 protein networkhttps://string-db.org/network/9606.ENSP00000348912Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain 33.
H2BC7 protein networkhttps://string-db.org/network/9606.ENSP00000348924H2B clustered histone 7.
FABP7 protein networkhttps://string-db.org/network/9606.ENSP00000348931Fatty acid-binding protein, brain; B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for [...]
CCDC25 protein networkhttps://string-db.org/network/9606.ENSP00000348933Coiled-coil domain containing 25; Belongs to the CCDC25 family.
RSPO1 protein networkhttps://string-db.org/network/9606.ENSP00000348944R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...]
MAN1A2 protein networkhttps://string-db.org/network/9606.ENSP00000348959Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce [...]
DYNC1H1 protein networkhttps://string-db.org/network/9606.ENSP00000348965Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the f [...]
WFDC11 protein networkhttps://string-db.org/network/9606.ENSP00000348968Protein WFDC11; WAP four-disulfide core domain 11.
MEGF6 protein networkhttps://string-db.org/network/9606.ENSP00000348982Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6.
SON protein networkhttps://string-db.org/network/9606.ENSP00000348984Protein SON; RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-c [...]
PTGER3 protein networkhttps://string-db.org/network/9606.ENSP00000349003Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to [...]
PEX14 protein networkhttps://string-db.org/network/9606.ENSP00000349016Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic [...]
ARC protein networkhttps://string-db.org/network/9606.ENSP00000349022Activity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transf [...]
NRARP protein networkhttps://string-db.org/network/9606.ENSP00000349041Notch-regulated ankyrin repeat-containing protein; Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstrea [...]
OSCP1 protein networkhttps://string-db.org/network/9606.ENSP00000349052Protein OSCP1; May be involved in drug clearance in the placenta.
FDPS protein networkhttps://string-db.org/network/9606.ENSP00000349078Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites includ [...]
MAGEA1 protein networkhttps://string-db.org/network/9606.ENSP00000349085Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) [...]
TMEM259 protein networkhttps://string-db.org/network/9606.ENSP00000349087Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against E [...]
SEPTIN10 protein networkhttps://string-db.org/network/9606.ENSP00000349116Septin-10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
PPP4R2 protein networkhttps://string-db.org/network/9606.ENSP00000349124Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule orga [...]
RSPO3 protein networkhttps://string-db.org/network/9606.ENSP00000349131R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6 [...]
ATP5F1C protein networkhttps://string-db.org/network/9606.ENSP00000349142ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...]
BTN2A2 protein networkhttps://string-db.org/network/9606.ENSP00000349143Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion. Belongs to the immunoglobulin [...]
CNNM1 protein networkhttps://string-db.org/network/9606.ENSP00000349147Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family.
SIAH1 protein networkhttps://string-db.org/network/9606.ENSP00000349156E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from a [...]
ZNF790 protein networkhttps://string-db.org/network/9606.ENSP00000349161Zinc finger protein 790; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HNRNPH1 protein networkhttps://string-db.org/network/9606.ENSP00000349168Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the [...]
HVCN1 protein networkhttps://string-db.org/network/9606.ENSP00000349181Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with the [...]
CRB3 protein networkhttps://string-db.org/network/9606.ENSP00000349204Protein crumbs homolog 3; Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.
PIK3R4 protein networkhttps://string-db.org/network/9606.ENSP00000349205Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a [...]
PIWIL2 protein networkhttps://string-db.org/network/9606.ENSP00000349208Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline i [...]
CCDC88B protein networkhttps://string-db.org/network/9606.ENSP00000349238Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+ [...]
EDRF1 protein networkhttps://string-db.org/network/9606.ENSP00000349244Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene.
ITGAL protein networkhttps://string-db.org/network/9606.ENSP00000349252Integrin alpha-L; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubi [...]
SPTBN1 protein networkhttps://string-db.org/network/9606.ENSP00000349259Spectrin beta chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent m [...]
HBM protein networkhttps://string-db.org/network/9606.ENSP00000349270Hemoglobin subunit mu.
PPP1R26 protein networkhttps://string-db.org/network/9606.ENSP00000349274Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation.
ARMCX2 protein networkhttps://string-db.org/network/9606.ENSP00000349281Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells.
TBC1D9B protein networkhttps://string-db.org/network/9606.ENSP00000349291TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s).
TMEM71 protein networkhttps://string-db.org/network/9606.ENSP00000349296Transmembrane protein 71; Belongs to the TMEM71 family.
MYLIP protein networkhttps://string-db.org/network/9606.ENSP00000349298E3 ubiquitin-protein ligase MYLIP; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. A [...]
GOLGA4 protein networkhttps://string-db.org/network/9606.ENSP00000349305Golgin subfamily A member 4; Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi [...]
NHEJ1 protein networkhttps://string-db.org/network/9606.ENSP00000349313Non-homologous end-joining factor 1; DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a brid [...]
CACNA2D1 protein networkhttps://string-db.org/network/9606.ENSP00000349320Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...]
TNFRSF10C protein networkhttps://string-db.org/network/9606.ENSP00000349324Tumor necrosis factor receptor superfamily member 10C; Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells [...]
BICD2 protein networkhttps://string-db.org/network/9606.ENSP00000349351Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence [...]
C12orf29 protein networkhttps://string-db.org/network/9606.ENSP00000349358Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29.
SASH3 protein networkhttps://string-db.org/network/9606.ENSP00000349359SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes.
IL27 protein networkhttps://string-db.org/network/9606.ENSP00000349365Interleukin-27 subunit alpha; Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, tha [...]
ABCD4 protein networkhttps://string-db.org/network/9606.ENSP00000349396ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.
SLITRK4 protein networkhttps://string-db.org/network/9606.ENSP00000349400SLIT and NTRK-like protein 4; It is involved in synaptogenesis and promotes synapse differentiation. Suppresses neurite outgrowth (By similarity); Belongs to the SLITRK family.
ZNF708 protein networkhttps://string-db.org/network/9606.ENSP00000349401Zinc finger protein 708; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PTBP1 protein networkhttps://string-db.org/network/9606.ENSP00000349428Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell dif [...]
H2BC12 protein networkhttps://string-db.org/network/9606.ENSP00000349430Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
ADAM15 protein networkhttps://string-db.org/network/9606.ENSP00000349436Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both h [...]
IGF2R protein networkhttps://string-db.org/network/9606.ENSP00000349437Cation-independent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl [...]
TXNDC11 protein networkhttps://string-db.org/network/9606.ENSP00000349439Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex co [...]
ARG1 protein networkhttps://string-db.org/network/9606.ENSP00000349446Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bio [...]
CLCC1 protein networkhttps://string-db.org/network/9606.ENSP00000349456Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel. Plays a role in retina development. Belongs to the chloride channel MCLC family.
ICK protein networkhttps://string-db.org/network/9606.ENSP00000349458Serine/threonine-protein kinase ICK; Required for ciliogenesis. Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway [...]
SPINK14 protein networkhttps://string-db.org/network/9606.ENSP00000349459Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor.
SCRIB protein networkhttps://string-db.org/network/9606.ENSP00000349486Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establ [...]
MFNG protein networkhttps://string-db.org/network/9606.ENSP00000349490Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of No [...]
GUCA2A protein networkhttps://string-db.org/network/9606.ENSP00000349493HMW-guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin fam [...]
ZNF254 protein networkhttps://string-db.org/network/9606.ENSP00000349494Zinc finger protein 254; May be involved in transcriptional regulation.
ZBTB14 protein networkhttps://string-db.org/network/9606.ENSP00000349503Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA- 3'. Binds to 5 [...]
CAVIN1 protein networkhttps://string-db.org/network/9606.ENSP00000349541Caveolae-associated protein 1; Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is [...]
PEX2 protein networkhttps://string-db.org/network/9606.ENSP00000349543Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family.
RASSF1 protein networkhttps://string-db.org/network/9606.ENSP00000349547Ras association domain-containing protein 1; Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apopto [...]
CFAP43 protein networkhttps://string-db.org/network/9606.ENSP00000349568Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.
MOB3A protein networkhttps://string-db.org/network/9606.ENSP00000349575MOB kinase activator 3A; May regulate the activity of kinases.
DCTD protein networkhttps://string-db.org/network/9606.ENSP00000349576Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase.
PRODH protein networkhttps://string-db.org/network/9606.ENSP00000349577Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.
ANK2 protein networkhttps://string-db.org/network/9606.ENSP00000349588Ankyrin-2; Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated musc [...]
ZHX1-C8orf76 protein networkhttps://string-db.org/network/9606.ENSP00000349593Zinc fingers and homeoboxes protein 1, isoform 2; ZHX1-C8orf76 readthrough.
ELAVL4 protein networkhttps://string-db.org/network/9606.ENSP00000349594ELAV-like protein 4; RNA-binding protein that is involved in the post- transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. [...]
ATP2A1 protein networkhttps://string-db.org/network/9606.ENSP00000349595Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sa [...]
TRIM38 protein networkhttps://string-db.org/network/9606.ENSP00000349596E3 ubiquitin-protein ligase TRIM38; E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediat [...]
ADIPOR2 protein networkhttps://string-db.org/network/9606.ENSP00000349616Adiponectin receptor protein 2; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. [...]
LRBA protein networkhttps://string-db.org/network/9606.ENSP00000349629Lipopolysaccharide-responsive and beige-like anchor protein; May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of im [...]
MCRS1 protein networkhttps://string-db.org/network/9606.ENSP00000349640Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal hist [...]
XPNPEP3 protein networkhttps://string-db.org/network/9606.ENSP00000349658Xaa-Pro aminopeptidase 3; Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at th [...]
TEX43 protein networkhttps://string-db.org/network/9606.ENSP00000349669Testis-expressed protein 43; Testis expressed 43.
SPOCK3 protein networkhttps://string-db.org/network/9606.ENSP00000349677Testican-3; May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
MYBPHL protein networkhttps://string-db.org/network/9606.ENSP00000349678Myosin-binding protein H-like; Myosin binding protein H like; Belongs to the immunoglobulin superfamily. MyBP family.
DYNLRB1 protein networkhttps://string-db.org/network/9606.ENSP00000349679Dynein light chain roadblock-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and [...]
GM2A protein networkhttps://string-db.org/network/9606.ENSP00000349687Ganglioside GM2 activator isoform short; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium- independent phospholipase ac [...]
ZDHHC9 protein networkhttps://string-db.org/network/9606.ENSP00000349689Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
ZMYM6 protein networkhttps://string-db.org/network/9606.ENSP00000349708Zinc finger MYM-type protein 6; Plays a role in the regulation of cell morphology and cytoskeletal organization.
RAET1E protein networkhttps://string-db.org/network/9606.ENSP00000349709Retinoic acid early transcript 1E; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family.
UBE2D3 protein networkhttps://string-db.org/network/9606.ENSP00000349722Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family.
BCL11B protein networkhttps://string-db.org/network/9606.ENSP00000349723B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopo [...]
DOK3 protein networkhttps://string-db.org/network/9606.ENSP00000349727Docking protein 3; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative [...]
C3orf18 protein networkhttps://string-db.org/network/9606.ENSP00000349732Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18.
SFPQ protein networkhttps://string-db.org/network/9606.ENSP00000349748Splicing factor, proline- and glutamine-rich; DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and f [...]
DCHS2 protein networkhttps://string-db.org/network/9606.ENSP00000349768Protocadherin-23; Calcium-dependent cell-adhesion protein.
TBC1D8B protein networkhttps://string-db.org/network/9606.ENSP00000349781TBC1 domain family member 8B; Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein.
MAP1LC3C protein networkhttps://string-db.org/network/9606.ENSP00000349785Microtubule-associated proteins 1A/1B light chain 3C; Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits [...]
COL9A1 protein networkhttps://string-db.org/network/9606.ENSP00000349790Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye.
INKA2 protein networkhttps://string-db.org/network/9606.ENSP00000349805PAK4-inhibitor INKA2; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity; Belongs to the INKA family.
SMARCAL1 protein networkhttps://string-db.org/network/9606.ENSP00000349823SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA [...]
REPS2 protein networkhttps://string-db.org/network/9606.ENSP00000349824RalBP1-associated Eps domain-containing protein 2; Involved in growth factor signaling through its influence on the Ral signaling pathway.
PRRC2B protein networkhttps://string-db.org/network/9606.ENSP00000349856Protein PRRC2B; Proline rich coiled-coil 2B.
GFPT1 protein networkhttps://string-db.org/network/9606.ENSP00000349860Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N [...]
NUDT13 protein networkhttps://string-db.org/network/9606.ENSP00000349874Nucleoside diphosphate-linked moiety X motif 13; Nudix hydrolase 13.
ATP13A1 protein networkhttps://string-db.org/network/9606.ENSP00000349877Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis. Belongs to the cation transpor [...]
GALP protein networkhttps://string-db.org/network/9606.ENSP00000349884Galanin-like peptide; [Isoform 1]: Hypothalamic neuropeptide which binds to the G- protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological [...]
ANKRD20A4 protein networkhttps://string-db.org/network/9606.ENSP00000349891Ankyrin repeat domain-containing protein 20A4.
DLK2 protein networkhttps://string-db.org/network/9606.ENSP00000349893Protein delta homolog 2; Regulates adipogenesis.
LAGE3 protein networkhttps://string-db.org/network/9606.ENSP00000349923EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...]
ENTR1 protein networkhttps://string-db.org/network/9606.ENSP00000349929Endosome-associated-trafficking regulator 1; Endosome-associated protein that plays a role in membrane receptor sorting, cytokinesis and ciliogenesis. Involved in the endosome-to-plasma membrane [...]
OR11G2 protein networkhttps://string-db.org/network/9606.ENSP00000349930Olfactory receptor 11G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PRAMEF8 protein networkhttps://string-db.org/network/9606.ENSP00000349931PRAME family member 8; Belongs to the PRAME family.
OR5B17 protein networkhttps://string-db.org/network/9606.ENSP00000349945Olfactory receptor 5B17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CGB3 protein networkhttps://string-db.org/network/9606.ENSP00000349954Chorionic gonadotropin subunit beta 3.
ANAPC11 protein networkhttps://string-db.org/network/9606.ENSP00000349957Anaphase-promoting complex subunit 11; Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 [...]
CCRL2 protein networkhttps://string-db.org/network/9606.ENSP00000349967C-C chemokine receptor-like 2; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capt [...]
ERGIC3 protein networkhttps://string-db.org/network/9606.ENSP00000349970Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family.
CEACAM3 protein networkhttps://string-db.org/network/9606.ENSP00000349971Carcinoembryonic antigen-related cell adhesion molecule 3; Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, includ [...]
GIP protein networkhttps://string-db.org/network/9606.ENSP00000350005Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
ACSL3 protein networkhttps://string-db.org/network/9606.ENSP00000350012Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation. Required for the inco [...]
FRMD4A protein networkhttps://string-db.org/network/9606.ENSP00000350032FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRM [...]
SMC1B protein networkhttps://string-db.org/network/9606.ENSP00000350036Structural maintenance of chromosomes protein 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its esta [...]
HOMEZ protein networkhttps://string-db.org/network/9606.ENSP00000350049Homeobox and leucine zipper protein Homez; May function as a transcriptional regulator.
TMEM229B protein networkhttps://string-db.org/network/9606.ENSP00000350050Transmembrane protein 229B.
ECE2 protein networkhttps://string-db.org/network/9606.ENSP00000350066Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, p [...]
STRN3 protein networkhttps://string-db.org/network/9606.ENSP00000350071Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein.
ARPIN protein networkhttps://string-db.org/network/9606.ENSP00000350075Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoher [...]
ARID5A protein networkhttps://string-db.org/network/9606.ENSP00000350078AT-rich interactive domain-containing protein 5A; Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repre [...]
ZNF43 protein networkhttps://string-db.org/network/9606.ENSP00000350085Zinc finger protein 43; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HNRNPA1L2 protein networkhttps://string-db.org/network/9606.ENSP00000350090Heterogeneous nuclear ribonucleoprotein A1-like 2; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice [...]
POP5 protein networkhttps://string-db.org/network/9606.ENSP00000350098Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease co [...]
TOR4A protein networkhttps://string-db.org/network/9606.ENSP00000350102Torsin-4A; Torsin family 4 member A.
PLN protein networkhttps://string-db.org/network/9606.ENSP00000350132Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of th [...]
RIMKLB protein networkhttps://string-db.org/network/9606.ENSP00000350136Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N- acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-a [...]
SYCP2 protein networkhttps://string-db.org/network/9606.ENSP00000350162Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Requ [...]
FXR1 protein networkhttps://string-db.org/network/9606.ENSP00000350170Fragile X mental retardation syndrome-related protein 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local tran [...]
MAP3K6 protein networkhttps://string-db.org/network/9606.ENSP00000350195Mitogen-activated protein kinase kinase kinase 6; Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.
SSTR2 protein networkhttps://string-db.org/network/9606.ENSP00000350198Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates [...]
AP1B1 protein networkhttps://string-db.org/network/9606.ENSP00000350199AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP com [...]
DNAJC14 protein networkhttps://string-db.org/network/9606.ENSP00000350223DnaJ homolog subfamily C member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.
BMX protein networkhttps://string-db.org/network/9606.ENSP00000350224Cytoplasmic tyrosine-protein kinase BMX; Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganiza [...]
POT1 protein networkhttps://string-db.org/network/9606.ENSP00000350249Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded t [...]
CCR9 protein networkhttps://string-db.org/network/9606.ENSP00000350256C-C chemokine receptor type 9; Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 [...]
FAM219B protein networkhttps://string-db.org/network/9606.ENSP00000350260Protein FAM219B; Family with sequence similarity 219 member B.
DENND2D protein networkhttps://string-db.org/network/9606.ENSP00000350266DENN domain-containing protein 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...]
BRPF3 protein networkhttps://string-db.org/network/9606.ENSP00000350267Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
SLC30A7 protein networkhttps://string-db.org/network/9606.ENSP00000350278Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requi [...]
ZNF816 protein networkhttps://string-db.org/network/9606.ENSP00000350295Zinc finger protein 816; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP2B4 protein networkhttps://string-db.org/network/9606.ENSP00000350310Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the ce [...]
BCO2 protein networkhttps://string-db.org/network/9606.ENSP00000350314Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta- ionone. Besides beta-carotene, l [...]
ASB13 protein networkhttps://string-db.org/network/9606.ENSP00000350331Ankyrin repeat and SOCS box protein 13; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
MYBPC2 protein networkhttps://string-db.org/network/9606.ENSP00000350332Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin fil [...]
SAP130 protein networkhttps://string-db.org/network/9606.ENSP00000350333Histone deacetylase complex subunit SAP130; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interacti [...]
GRM7 protein networkhttps://string-db.org/network/9606.ENSP00000350348Metabotropic glutamate receptor 7; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
ETFBKMT protein networkhttps://string-db.org/network/9606.ENSP00000350353Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negativel [...]
PRAMEF12 protein networkhttps://string-db.org/network/9606.ENSP00000350358PRAME family member 12; Belongs to the PRAME family.
CREB5 protein networkhttps://string-db.org/network/9606.ENSP00000350359Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription.
NEGR1 protein networkhttps://string-db.org/network/9606.ENSP00000350364Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belon [...]
MAFG protein networkhttps://string-db.org/network/9606.ENSP00000350369Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve [...]
MCTP2 protein networkhttps://string-db.org/network/9606.ENSP00000350377Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family.
GOLGA7 protein networkhttps://string-db.org/network/9606.ENSP00000350378Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
CHM protein networkhttps://string-db.org/network/9606.ENSP00000350386Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate p [...]
HHLA2 protein networkhttps://string-db.org/network/9606.ENSP00000350402HERV-H LTR-associating protein 2; Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT [...]
GJA9 protein networkhttps://string-db.org/network/9606.ENSP00000350415Gap junction alpha-9 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
ZNF98 protein networkhttps://string-db.org/network/9606.ENSP00000350418Zinc finger protein 98; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
APOA4 protein networkhttps://string-db.org/network/9606.ENSP00000350425Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a [...]
SGO2 protein networkhttps://string-db.org/network/9606.ENSP00000350447Shugoshin 2; Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres f [...]
PRIM1 protein networkhttps://string-db.org/network/9606.ENSP00000350491DNA primase small subunit; Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an es [...]
AIG1 protein networkhttps://string-db.org/network/9606.ENSP00000350509Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal [...]
COPS5 protein networkhttps://string-db.org/network/9606.ENSP00000350512COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an esse [...]
LVRN protein networkhttps://string-db.org/network/9606.ENSP00000350541Aminopeptidase Q; Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a ma [...]
SEMA4F protein networkhttps://string-db.org/network/9606.ENSP00000350547Semaphorin-4F; Probable cell surface receptor that regulates oligodendroglial precursor cell migration (By similarity). Might also regulate differentiation of oligodendroglial precursor cells (By [...]
HMX3 protein networkhttps://string-db.org/network/9606.ENSP00000350549Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core seque [...]
RFX4 protein networkhttps://string-db.org/network/9606.ENSP00000350552Transcription factor RFX4; Transcription factor that plays a role in early brain development. May activate transcription by interacting directly with the X-box. May activate transcription from CX [...]
ZBTB44 protein networkhttps://string-db.org/network/9606.ENSP00000350574Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation.
ZNF441 protein networkhttps://string-db.org/network/9606.ENSP00000350576Zinc finger protein 441; May be involved in transcriptional regulation.
TLL2 protein networkhttps://string-db.org/network/9606.ENSP00000350630Tolloid-like protein 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral [...]
SERTAD1 protein networkhttps://string-db.org/network/9606.ENSP00000350633SERTA domain-containing protein 1; Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 [...]
ERI2 protein networkhttps://string-db.org/network/9606.ENSP00000350651ERI1 exoribonuclease family member 2; Belongs to the ERI2 family.
FAM3B protein networkhttps://string-db.org/network/9606.ENSP00000350673Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family.
PHF8 protein networkhttps://string-db.org/network/9606.ENSP00000350676Histone lysine demethylase PHF8; Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain developme [...]
ELK4 protein networkhttps://string-db.org/network/9606.ENSP00000350681ETS domain-containing protein Elk-4; Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by d [...]
ANKLE2 protein networkhttps://string-db.org/network/9606.ENSP00000350686Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF [...]
DDX47 protein networkhttps://string-db.org/network/9606.ENSP00000350698Probable ATP-dependent RNA helicase DDX47; Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors. Belongs to the DEAD box helicase famil [...]
C1orf109 protein networkhttps://string-db.org/network/9606.ENSP00000350704Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition.
RAD23B protein networkhttps://string-db.org/network/9606.ENSP00000350708UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultan [...]
TUSC1 protein networkhttps://string-db.org/network/9606.ENSP00000350716Tumor suppressor candidate 1.
TMCC2 protein networkhttps://string-db.org/network/9606.ENSP00000350718Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.
SYNE2 protein networkhttps://string-db.org/network/9606.ENSP00000350719Nesprin-2; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC [...]
ST7L protein networkhttps://string-db.org/network/9606.ENSP00000350734Suppression of tumorigenicity 7 like; Belongs to the ST7 family.
GMFB protein networkhttps://string-db.org/network/9606.ENSP00000350757Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding p [...]
ASIC4 protein networkhttps://string-db.org/network/9606.ENSP00000350786Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity.
NR3C2 protein networkhttps://string-db.org/network/9606.ENSP00000350815Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements [...]
MPPED2 protein networkhttps://string-db.org/network/9606.ENSP00000350833Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system.
PAX5 protein networkhttps://string-db.org/network/9606.ENSP00000350844Paired box protein Pax-5; May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specifi [...]
HMGN5 protein networkhttps://string-db.org/network/9606.ENSP00000350848High mobility group nucleosome-binding domain-containing protein 5; Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin com [...]
C8orf86 protein networkhttps://string-db.org/network/9606.ENSP00000350856Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86.
METTL9 protein networkhttps://string-db.org/network/9606.ENSP00000350874Methyltransferase-like protein 9; Methyltransferase like 9.
GRAMD1C protein networkhttps://string-db.org/network/9606.ENSP00000350881Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique doma [...]
EPHB4 protein networkhttps://string-db.org/network/9606.ENSP00000350896Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
CTSE protein networkhttps://string-db.org/network/9606.ENSP00000350911Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation [...]
GAD1 protein networkhttps://string-db.org/network/9606.ENSP00000350928Glutamate decarboxylase 1; Catalyzes the production of GABA.
RABEP2 protein networkhttps://string-db.org/network/9606.ENSP00000350934Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor [...]
TES protein networkhttps://string-db.org/network/9606.ENSP00000350937Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act a [...]
GMPPA protein networkhttps://string-db.org/network/9606.ENSP00000350949Mannose-1-phosphate guanyltransferase alpha; May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose.
DMAC1 protein networkhttps://string-db.org/network/9606.ENSP00000350961Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of [...]
RTP2 protein networkhttps://string-db.org/network/9606.ENSP00000350976Receptor-transporting protein 2; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs.
LCA5L protein networkhttps://string-db.org/network/9606.ENSP00000351008Lebercilin-like protein; Lebercilin LCA5 like.
NF1 protein networkhttps://string-db.org/network/9606.ENSP00000351015Neurofibromin truncated; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity.
TPM1 protein networkhttps://string-db.org/network/9606.ENSP00000351022Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebra [...]
HSD17B11 protein networkhttps://string-db.org/network/9606.ENSP00000351035Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidoge [...]
FAM217B protein networkhttps://string-db.org/network/9606.ENSP00000351040Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family.
ZNF100 protein networkhttps://string-db.org/network/9606.ENSP00000351042Zinc finger protein 100; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZC3HC1 protein networkhttps://string-db.org/network/9606.ENSP00000351052Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of [...]
CX3CR1 protein networkhttps://string-db.org/network/9606.ENSP00000351059CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV- 1 vir [...]
SUSD2 protein networkhttps://string-db.org/network/9606.ENSP00000351075Sushi domain-containing protein 2; May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G [...]
WDR55 protein networkhttps://string-db.org/network/9606.ENSP00000351100WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).
FRYL protein networkhttps://string-db.org/network/9606.ENSP00000351113Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning se [...]
RHOT1 protein networkhttps://string-db.org/network/9606.ENSP00000351132Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
XAB2 protein networkhttps://string-db.org/network/9606.ENSP00000351137Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing. Belongs to the c [...]
MIGA2 protein networkhttps://string-db.org/network/9606.ENSP00000351138Mitoguardin 2; Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regu [...]
WTAP protein networkhttps://string-db.org/network/9606.ENSP00000351141Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency [...]
GRM8 protein networkhttps://string-db.org/network/9606.ENSP00000351142Metabotropic glutamate receptor 8; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
DCAF4 protein networkhttps://string-db.org/network/9606.ENSP00000351147DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
ATL1 protein networkhttps://string-db.org/network/9606.ENSP00000351155Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...]
TXNDC15 protein networkhttps://string-db.org/network/9606.ENSP00000351157Thioredoxin domain-containing protein 15; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis.
CNOT3 protein networkhttps://string-db.org/network/9606.ENSP00000351159CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...]
DNA2 protein networkhttps://string-db.org/network/9606.ENSP00000351185DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long [...]
ITIH2 protein networkhttps://string-db.org/network/9606.ENSP00000351190Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...]
TXLNB protein networkhttps://string-db.org/network/9606.ENSP00000351206Beta-taxilin; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic; Belongs to the taxilin family.
KIAA1671 protein networkhttps://string-db.org/network/9606.ENSP00000351207Uncharacterized protein KIAA1671; KIAA1671.
EPHA2 protein networkhttps://string-db.org/network/9606.ENSP00000351209Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signali [...]
OR6C6 protein networkhttps://string-db.org/network/9606.ENSP00000351211Olfactory receptor 6C6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TOMM7 protein networkhttps://string-db.org/network/9606.ENSP00000351214Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stab [...]
PDE11A-2 protein networkhttps://string-db.org/network/9606.ENSP00000351232Phosphodiesterase 11A.
VN1R2 protein networkhttps://string-db.org/network/9606.ENSP00000351244Vomeronasal type-1 receptor 2; Putative pheromone receptor.
TRIM33 protein networkhttps://string-db.org/network/9606.ENSP00000351250E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to doe [...]
STAT4 protein networkhttps://string-db.org/network/9606.ENSP00000351255Signal transducer and activator of transcription 4; Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
CASP8 protein networkhttps://string-db.org/network/9606.ENSP00000351273Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD [...]
ZNF429 protein networkhttps://string-db.org/network/9606.ENSP00000351280Zinc finger protein 429; May be involved in transcriptional regulation.
RAD52 protein networkhttps://string-db.org/network/9606.ENSP00000351284DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-strande [...]
COL6A6 protein networkhttps://string-db.org/network/9606.ENSP00000351310Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein.
PSMB10 protein networkhttps://string-db.org/network/9606.ENSP00000351314Proteasome subunit beta type-10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the le [...]
PLEKHG1 protein networkhttps://string-db.org/network/9606.ENSP00000351318Pleckstrin homology and RhoGEF domain containing G1.
PATE2 protein networkhttps://string-db.org/network/9606.ENSP00000351325Prostate and testis expressed 2.
AKAP4 protein networkhttps://string-db.org/network/9606.ENSP00000351327A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family.
ARHGAP19 protein networkhttps://string-db.org/network/9606.ENSP00000351333Rho GTPase-activating protein 19; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
PLXNB1 protein networkhttps://string-db.org/network/9606.ENSP00000351338Plexin-B1; Receptor for SEMA4D. Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role i [...]
PTPN5 protein networkhttps://string-db.org/network/9606.ENSP00000351342Tyrosine-protein phosphatase non-receptor type 5; May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family k [...]
ALKAL1 protein networkhttps://string-db.org/network/9606.ENSP00000351345ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly.
VPS13B protein networkhttps://string-db.org/network/9606.ENSP00000351346Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family.
PFN3 protein networkhttps://string-db.org/network/9606.ENSP00000351379Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatid [...]
TMA16 protein networkhttps://string-db.org/network/9606.ENSP00000351380Translation machinery associated 16 homolog.
ZNF781 protein networkhttps://string-db.org/network/9606.ENSP00000351391Zinc finger protein 781; May be involved in transcriptional regulation.
SCGB1D4 protein networkhttps://string-db.org/network/9606.ENSP00000351395Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily.
ARNT protein networkhttps://string-db.org/network/9606.ENSP00000351407Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the n [...]
ANKRD17 protein networkhttps://string-db.org/network/9606.ENSP00000351416Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA r [...]
REX1BD protein networkhttps://string-db.org/network/9606.ENSP00000351422Required for excision 1-B domain containing.
GYPE protein networkhttps://string-db.org/network/9606.ENSP00000351430Glycophorin-E; This protein is a minor sialoglycoprotein in human erythrocyte membranes; Belongs to the glycophorin-A family.
WDR5 protein networkhttps://string-db.org/network/9606.ENSP00000351446WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is invo [...]
OR5AC2 protein networkhttps://string-db.org/network/9606.ENSP00000351466Olfactory receptor 5AC2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GIMAP5 protein networkhttps://string-db.org/network/9606.ENSP00000351473GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequesterin [...]
PASK protein networkhttps://string-db.org/network/9606.ENSP00000351475PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably [...]
NAALADL1 protein networkhttps://string-db.org/network/9606.ENSP00000351484Aminopeptidase NAALADL1; Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity w [...]
MAX protein networkhttps://string-db.org/network/9606.ENSP00000351490Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcrip [...]
UBL5 protein networkhttps://string-db.org/network/9606.ENSP00000351492Ubiquitin-like protein 5; Ubiquitin like 5.
FCGR2B protein networkhttps://string-db.org/network/9606.ENSP00000351497Low affinity immunoglobulin gamma Fc region receptor II-b; Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector an [...]
ENTPD4 protein networkhttps://string-db.org/network/9606.ENSP00000351520Ectonucleoside triphosphate diphosphohydrolase 4; Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity wi [...]
ZXDA protein networkhttps://string-db.org/network/9606.ENSP00000351530Zinc finger X-linked protein ZXDA; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
QSOX2 protein networkhttps://string-db.org/network/9606.ENSP00000351536Sulfhydryl oxidase 2; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond [...]
ZBTB18 protein networkhttps://string-db.org/network/9606.ENSP00000351539Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myog [...]
BDP1 protein networkhttps://string-db.org/network/9606.ENSP00000351575Transcription factor TFIIIB component B'' homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for [...]
H2AC13 protein networkhttps://string-db.org/network/9606.ENSP00000351589Histone H2A type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones [...]
NLGN3 protein networkhttps://string-db.org/network/9606.ENSP00000351591Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may [...]
FUT4 protein networkhttps://string-db.org/network/9606.ENSP00000351602Alpha-(1,3)-fucosyltransferase 4; May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
FZD6 protein networkhttps://string-db.org/network/9606.ENSP00000351605Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...]
SYN3 protein networkhttps://string-db.org/network/9606.ENSP00000351614Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis.
PBLD protein networkhttps://string-db.org/network/9606.ENSP00000351619Phenazine biosynthesis like protein domain containing.
FAM76B protein networkhttps://string-db.org/network/9606.ENSP00000351631Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family.
FAM3D protein networkhttps://string-db.org/network/9606.ENSP00000351632Protein FAM3D; FAM3 metabolism regulating signaling molecule D; Belongs to the FAM3 family.
BCAS4 protein networkhttps://string-db.org/network/9606.ENSP00000351642Breast carcinoma amplified sequence 4; Belongs to the cappuccino family.
GTPBP3 protein networkhttps://string-db.org/network/9606.ENSP00000351644tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
STIP1 protein networkhttps://string-db.org/network/9606.ENSP00000351646Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).
MANEA protein networkhttps://string-db.org/network/9606.ENSP00000351669Glycoprotein endo-alpha-1,2-mannosidase; Mannosidase endo-alpha.
CCL20 protein networkhttps://string-db.org/network/9606.ENSP00000351671C-C motif chemokine 20; Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellula [...]
CNDP1 protein networkhttps://string-db.org/network/9606.ENSP00000351682Carnosine dipeptidase 1; Belongs to the peptidase M20A family.
PRDM10 protein networkhttps://string-db.org/network/9606.ENSP00000351686PR domain zinc finger protein 10; May be involved in transcriptional regulation.
REV3L protein networkhttps://string-db.org/network/9606.ENSP00000351697DNA polymerase zeta catalytic subunit; Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exo [...]
GK2 protein networkhttps://string-db.org/network/9606.ENSP00000351706Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family.
CCER1 protein networkhttps://string-db.org/network/9606.ENSP00000351727Coiled-coil glutamate rich protein 1.
TMC2 protein networkhttps://string-db.org/network/9606.ENSP00000351732Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in m [...]
TMEM126B protein networkhttps://string-db.org/network/9606.ENSP00000351737Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing [...]
FAM114A1 protein networkhttps://string-db.org/network/9606.ENSP00000351740Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family.
TFEB protein networkhttps://string-db.org/network/9606.ENSP00000351742Transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TF [...]
COL20A1 protein networkhttps://string-db.org/network/9606.ENSP00000351767Collagen alpha-1(XX) chain; Probable collagen protein.
FHAD1 protein networkhttps://string-db.org/network/9606.ENSP00000351770Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1.
VCP protein networkhttps://string-db.org/network/9606.ENSP00000351777Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional end [...]
PELI1 protein networkhttps://string-db.org/network/9606.ENSP00000351789E3 ubiquitin-protein ligase pellino homolog 1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathwa [...]
MYPN protein networkhttps://string-db.org/network/9606.ENSP00000351790Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family.
ELN protein networkhttps://string-db.org/network/9606.ENSP00000351807Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabili [...]
EDC4 protein networkhttps://string-db.org/network/9606.ENSP00000351811Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of [...]
MARCHF5 protein networkhttps://string-db.org/network/9606.ENSP00000351813E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondr [...]
RAB3GAP2 protein networkhttps://string-db.org/network/9606.ENSP00000351832Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are [...]
POTEC protein networkhttps://string-db.org/network/9606.ENSP00000351856POTE ankyrin domain family member C.
SPANXC protein networkhttps://string-db.org/network/9606.ENSP00000351884Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family.
TGFBR2 protein networkhttps://string-db.org/network/9606.ENSP00000351905TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokine [...]
MAP3K5 protein networkhttps://string-db.org/network/9606.ENSP00000351908Mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...]
AP2A1 protein networkhttps://string-db.org/network/9606.ENSP00000351926AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathw [...]
KLHL9 protein networkhttps://string-db.org/network/9606.ENSP00000351933Kelch-like protein 9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin [...]
C17orf80 protein networkhttps://string-db.org/network/9606.ENSP00000351937Uncharacterized protein C17orf80; Chromosome 17 open reading frame 80.
SMARCAD1 protein networkhttps://string-db.org/network/9606.ENSP00000351947ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end [...]
PDE3A protein networkhttps://string-db.org/network/9606.ENSP00000351957cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important ph [...]
SFTA2 protein networkhttps://string-db.org/network/9606.ENSP00000351989Surfactant-associated protein 2; Putative surfactant protein.
NAE1 protein networkhttps://string-db.org/network/9606.ENSP00000351990NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter l [...]
CACNA1G protein networkhttps://string-db.org/network/9606.ENSP00000352011Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...]
NOL12 protein networkhttps://string-db.org/network/9606.ENSP00000352021Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family.
KCNQ2 protein networkhttps://string-db.org/network/9606.ENSP00000352035Potassium voltage-gated channel subfamily KQT member 2; Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a s [...]
NLRC3 protein networkhttps://string-db.org/network/9606.ENSP00000352039NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM1 [...]
WWP2 protein networkhttps://string-db.org/network/9606.ENSP00000352069NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...]
CD163 protein networkhttps://string-db.org/network/9606.ENSP00000352071Scavenger receptor cysteine-rich type 1 protein M130; Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby prote [...]
SPTSSB protein networkhttps://string-db.org/network/9606.ENSP00000352097Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrat [...]
GOLGA8A protein networkhttps://string-db.org/network/9606.ENSP00000352111Golgin subfamily A member 8A; May be involved in maintaining Golgi structure.
H2AC11 protein networkhttps://string-db.org/network/9606.ENSP00000352119H2A clustered histone 11.
KIRREL1 protein networkhttps://string-db.org/network/9606.ENSP00000352138Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans [...]
ELAVL3 protein networkhttps://string-db.org/network/9606.ENSP00000352162ELAV-like protein 3; RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved [...]
LYPD2 protein networkhttps://string-db.org/network/9606.ENSP00000352163LY6/PLAUR domain containing 2.
SLC25A29 protein networkhttps://string-db.org/network/9606.ENSP00000352167Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in ce [...]
VSIG10 protein networkhttps://string-db.org/network/9606.ENSP00000352172V-set and immunoglobulin domain containing 10.
PLAC1 protein networkhttps://string-db.org/network/9606.ENSP00000352173Placenta-specific protein 1; May play a role in placental development. Belongs to the PLAC1 family.
FAM86C1 protein networkhttps://string-db.org/network/9606.ENSP00000352182Protein FAM86C1.
PHF2 protein networkhttps://string-db.org/network/9606.ENSP00000352185Lysine-specific demethylase PHF2; Lysine demethylase that demethylates both histones and non- histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by P [...]
MYOF protein networkhttps://string-db.org/network/9606.ENSP00000352208Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress [...]
SLC2A10 protein networkhttps://string-db.org/network/9606.ENSP00000352216Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter required for the development of the cardiovascular system; Belongs to the major facilitator su [...]
ZNF705A protein networkhttps://string-db.org/network/9606.ENSP00000352233Zinc finger protein 705A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ANXA10 protein networkhttps://string-db.org/network/9606.ENSP00000352248Annexin A10.
H3C12 protein networkhttps://string-db.org/network/9606.ENSP00000352252Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones there [...]
XRCC6 protein networkhttps://string-db.org/network/9606.ENSP00000352257X-ray repair cross-complementing protein 6; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork- [...]
CD2AP protein networkhttps://string-db.org/network/9606.ENSP00000352264CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regu [...]
TPGS1 protein networkhttps://string-db.org/network/9606.ENSP00000352265Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity).
AADACL3 protein networkhttps://string-db.org/network/9606.ENSP00000352268Arylacetamide deacetylase like 3; Belongs to the 'GDXG' lipolytic enzyme family.
XRCC2 protein networkhttps://string-db.org/network/9606.ENSP00000352271DNA repair protein XRCC2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of [...]
MYOZ1 protein networkhttps://string-db.org/network/9606.ENSP00000352272Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...]
KLHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000352282Kelch domain containing 1.
TMEM139 protein networkhttps://string-db.org/network/9606.ENSP00000352284Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1.
PLXNB2 protein networkhttps://string-db.org/network/9606.ENSP00000352288Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is requir [...]
CGB2 protein networkhttps://string-db.org/network/9606.ENSP00000352295Chorionic gonadotropin subunit beta 2.
SLFNL1 protein networkhttps://string-db.org/network/9606.ENSP00000352299Schlafen-like protein 1; Schlafen like 1.
KLHL14 protein networkhttps://string-db.org/network/9606.ENSP00000352314Kelch-like protein 14; Kelch like family member 14.
TRPV6 protein networkhttps://string-db.org/network/9606.ENSP00000352358Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca [...]
NUP214 protein networkhttps://string-db.org/network/9606.ENSP00000352400Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.
RPE protein networkhttps://string-db.org/network/9606.ENSP00000352401Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate.
BABAM1 protein networkhttps://string-db.org/network/9606.ENSP00000352408BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to t [...]
TMC3 protein networkhttps://string-db.org/network/9606.ENSP00000352413Transmembrane channel-like protein 3; Probable ion channel.
FGF17 protein networkhttps://string-db.org/network/9606.ENSP00000352414Fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for norm [...]
LDLRAD4 protein networkhttps://string-db.org/network/9606.ENSP00000352420Low-density lipoprotein receptor class A domain-containing protein 4; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiat [...]
TIAF1 protein networkhttps://string-db.org/network/9606.ENSP00000352424TGFB1-induced anti-apoptotic factor 1; Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alph [...]
RGR protein networkhttps://string-db.org/network/9606.ENSP00000352427RPE-retinal G protein-coupled receptor; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like [...]
PCBP2 protein networkhttps://string-db.org/network/9606.ENSP00000352438Poly(rC)-binding protein 2; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates [...]
ZNF33B protein networkhttps://string-db.org/network/9606.ENSP00000352444Zinc finger protein 33B; May be involved in transcriptional regulation.
C1orf116 protein networkhttps://string-db.org/network/9606.ENSP00000352447Specifically androgen-regulated gene protein; Putative androgen-specific receptor. Belongs to the SARG family.
MFAP5 protein networkhttps://string-db.org/network/9606.ENSP00000352455Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel int [...]
PLGLB2 protein networkhttps://string-db.org/network/9606.ENSP00000352458Plasminogen like B2.
TCF20 protein networkhttps://string-db.org/network/9606.ENSP00000352463Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional a [...]
TECPR2 protein networkhttps://string-db.org/network/9606.ENSP00000352510Tectonin beta-propeller repeat-containing protein 2; Probably plays a role as positive regulator of autophagy. Belongs to the WD repeat KIAA0329 family.
MPZL1 protein networkhttps://string-db.org/network/9606.ENSP00000352513Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP [...]
DNMT1 protein networkhttps://string-db.org/network/9606.ENSP00000352516DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern i [...]
ATP6V1H protein networkhttps://string-db.org/network/9606.ENSP00000352522V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar [...]
KCNK5 protein networkhttps://string-db.org/network/9606.ENSP00000352527Potassium channel subfamily K member 5; pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations.
GTF3C2 protein networkhttps://string-db.org/network/9606.ENSP00000352536General transcription factor 3C polypeptide 2; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required fo [...]
EMP2 protein networkhttps://string-db.org/network/9606.ENSP00000352540Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell mi [...]
CPLX2 protein networkhttps://string-db.org/network/9606.ENSP00000352544Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of [...]
CALCR protein networkhttps://string-db.org/network/9606.ENSP00000352561Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to th [...]
HAND2 protein networkhttps://string-db.org/network/9606.ENSP00000352565Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for v [...]
PCNT protein networkhttps://string-db.org/network/9606.ENSP00000352572Pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, togeth [...]
AKR1B10 protein networkhttps://string-db.org/network/9606.ENSP00000352584Aldo-keto reductase family 1 member B10; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic acti [...]
LRP10 protein networkhttps://string-db.org/network/9606.ENSP00000352601Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake [...]
OR2T3 protein networkhttps://string-db.org/network/9606.ENSP00000352604Olfactory receptor 2T3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RYR1 protein networkhttps://string-db.org/network/9606.ENSP00000352608Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction followin [...]
ZSWIM5 protein networkhttps://string-db.org/network/9606.ENSP00000352614Zinc finger SWIM-type containing 5.
OR6K2 protein networkhttps://string-db.org/network/9606.ENSP00000352626Olfactory receptor 6K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
H2AC17 protein networkhttps://string-db.org/network/9606.ENSP00000352627H2A clustered histone 17.
CELA2A protein networkhttps://string-db.org/network/9606.ENSP00000352639Chymotrypsin-like elastase family member 2A; Acts upon elastin.
LRRC61 protein networkhttps://string-db.org/network/9606.ENSP00000352642Leucine-rich repeat-containing protein 61; Leucine rich repeat containing 61.
TYW1 protein networkhttps://string-db.org/network/9606.ENSP00000352645S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base f [...]
PGLYRP4 protein networkhttps://string-db.org/network/9606.ENSP00000352672Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...]
ELF3 protein networkhttps://string-db.org/network/9606.ENSP00000352673ETS-related transcription factor Elf-3; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with [...]
ZRANB1 protein networkhttps://string-db.org/network/9606.ENSP00000352676Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'- [...]
SUPV3L1 protein networkhttps://string-db.org/network/9606.ENSP00000352678ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang dou [...]
HIBCH protein networkhttps://string-db.org/network/9606.ENSP000003527063-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrog [...]
G3BP2 protein networkhttps://string-db.org/network/9606.ENSP00000352738Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling.
DSG4 protein networkhttps://string-db.org/network/9606.ENSP00000352785Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition fr [...]
COL18A1 protein networkhttps://string-db.org/network/9606.ENSP00000352798Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin: Potently inhibits endothelial cell proli [...]
ZDHHC14 protein networkhttps://string-db.org/network/9606.ENSP00000352821Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type palmitoyltransferase 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
PTPN22 protein networkhttps://string-db.org/network/9606.ENSP00000352833Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TC [...]
MB protein networkhttps://string-db.org/network/9606.ENSP00000352835Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
ZNF675 protein networkhttps://string-db.org/network/9606.ENSP00000352836Zinc finger protein 675; May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity.
ZNF808 protein networkhttps://string-db.org/network/9606.ENSP00000352846Zinc finger protein 808; May be involved in transcriptional regulation.
SIRPB2 protein networkhttps://string-db.org/network/9606.ENSP00000352849Signal-regulatory protein beta-2; Signal regulatory protein beta 2.
PLXNA4 protein networkhttps://string-db.org/network/9606.ENSP00000352882Plexin-A4; Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Cla [...]
RXRG protein networkhttps://string-db.org/network/9606.ENSP00000352900Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retin [...]
NT5C1B protein networkhttps://string-db.org/network/9606.ENSP00000352904Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
TRRAP protein networkhttps://string-db.org/network/9606.ENSP00000352925Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a sp [...]
TEAD4 protein networkhttps://string-db.org/network/9606.ENSP00000352926Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...]
MTCL1 protein networkhttps://string-db.org/network/9606.ENSP00000352927Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and ma [...]
DDA1 protein networkhttps://string-db.org/network/9606.ENSP00000352928DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform fo [...]
SPINK5 protein networkhttps://string-db.org/network/9606.ENSP00000352936Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti- inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity a [...]
KCTD18 protein networkhttps://string-db.org/network/9606.ENSP00000352941BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18.
RBM23 protein networkhttps://string-db.org/network/9606.ENSP00000352956Probable RNA-binding protein 23; Probable RNA-binding protein. May be involved in pre-mRNA splicing process; Belongs to the splicing factor SR family.
PLPPR3 protein networkhttps://string-db.org/network/9606.ENSP00000352962Phospholipid phosphatase-related protein type 3; Phospholipid phosphatase related 3.
ART5 protein networkhttps://string-db.org/network/9606.ENSP00000352992ADP-ribosyltransferase 5.
SULF2 protein networkhttps://string-db.org/network/9606.ENSP00000353007Extracellular sulfatase Sulf-2; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specif [...]
ATG2B protein networkhttps://string-db.org/network/9606.ENSP00000353010Autophagy-related protein 2 homolog B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Belongs to the ATG2 family.
CLEC14A protein networkhttps://string-db.org/network/9606.ENSP00000353013C-type lectin domain containing 14A.
FAM3C protein networkhttps://string-db.org/network/9606.ENSP00000353025Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
PTPRF protein networkhttps://string-db.org/network/9606.ENSP00000353030Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its a [...]
P2RX4 protein networkhttps://string-db.org/network/9606.ENSP00000353032P2X purinoceptor 4; Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.
CCT8L2 protein networkhttps://string-db.org/network/9606.ENSP00000353048T-complex protein 1 subunit theta-like 2; Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis; Belongs to the TCP-1 chaperonin family.
ZNF517 protein networkhttps://string-db.org/network/9606.ENSP00000353058Zinc finger protein 517; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP2A3 protein networkhttps://string-db.org/network/9606.ENSP00000353072Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytoso [...]
MCMBP protein networkhttps://string-db.org/network/9606.ENSP00000353098Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes [...]
HLA-DRB1 protein networkhttps://string-db.org/network/9606.ENSP00000353099HLA class II histocompatibility antigen, DRB1 beta chain; A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA- DRA, [...]
DHDDS protein networkhttps://string-db.org/network/9606.ENSP00000353104Dehydrodolichyl diphosphate synthase complex subunit DHDDS; With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) b [...]
AHNAK2 protein networkhttps://string-db.org/network/9606.ENSP00000353114AHNAK nucleoprotein 2.
DCAF12L2 protein networkhttps://string-db.org/network/9606.ENSP00000353128DDB1- and CUL4-associated factor 12-like protein 2; DDB1 and CUL4 associated factor 12 like 2; Belongs to the WD repeat DCAF12 family.
KCTD8 protein networkhttps://string-db.org/network/9606.ENSP00000353129BTB/POZ domain-containing protein KCTD8; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...]
DMBX1 protein networkhttps://string-db.org/network/9606.ENSP00000353132Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. May repress OTX2- mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3 [...]
GAL3ST4 protein networkhttps://string-db.org/network/9606.ENSP00000353142Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and [...]
TPK1 protein networkhttps://string-db.org/network/9606.ENSP00000353165Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.
PYY protein networkhttps://string-db.org/network/9606.ENSP00000353198Peptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
LCE1B protein networkhttps://string-db.org/network/9606.ENSP00000353203Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.
C17orf97 protein networkhttps://string-db.org/network/9606.ENSP00000353245Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation.
MAK16 protein networkhttps://string-db.org/network/9606.ENSP00000353246MAK16 homolog.
AGBL5 protein networkhttps://string-db.org/network/9606.ENSP00000353249Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains g [...]
CD300A protein networkhttps://string-db.org/network/9606.ENSP00000353259CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. [...]
ERGIC2 protein networkhttps://string-db.org/network/9606.ENSP00000353270Endoplasmic reticulum-Golgi intermediate compartment protein 2; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family.
DDX3Y protein networkhttps://string-db.org/network/9606.ENSP00000353284ATP-dependent RNA helicase DDX3Y; Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway (By similarity). Belongs to the DEAD box helicase [...]
SCNN1A protein networkhttps://string-db.org/network/9606.ENSP00000353292Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...]
CBWD3 protein networkhttps://string-db.org/network/9606.ENSP00000353295COBW domain containing 3.
KIRREL2 protein networkhttps://string-db.org/network/9606.ENSP00000353331Kin of IRRE-like protein 2; May regulate basal insulin secretion. Belongs to the immunoglobulin superfamily.
RTEL1 protein networkhttps://string-db.org/network/9606.ENSP00000353332Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase [...]
OR52M1 protein networkhttps://string-db.org/network/9606.ENSP00000353343Olfactory receptor 52M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ETS2 protein networkhttps://string-db.org/network/9606.ENSP00000353344Protein C-ets-2; Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
MAP4 protein networkhttps://string-db.org/network/9606.ENSP00000353375Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
CCDC102B protein networkhttps://string-db.org/network/9606.ENSP00000353377Coiled-coil domain containing 102B.
MAGEA4 protein networkhttps://string-db.org/network/9606.ENSP00000353379Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
F8 protein networkhttps://string-db.org/network/9606.ENSP00000353393Factor VIIIa heavy chain, 200 kDa isoform; Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
CUX1 protein networkhttps://string-db.org/network/9606.ENSP00000353401Homeobox protein cut-like 1; Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in [...]
MSN protein networkhttps://string-db.org/network/9606.ENSP00000353408Moesin; Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cort [...]
ATP2B2 protein networkhttps://string-db.org/network/9606.ENSP00000353414Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.
VPS13A protein networkhttps://string-db.org/network/9606.ENSP00000353422Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane.
RAB5B protein networkhttps://string-db.org/network/9606.ENSP00000353444Ras-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity).
MYLK protein networkhttps://string-db.org/network/9606.ENSP00000353452Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light c [...]
CASS4 protein networkhttps://string-db.org/network/9606.ENSP00000353462Cas scaffolding protein family member 4; Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhe [...]
C20orf96 protein networkhttps://string-db.org/network/9606.ENSP00000353470Uncharacterized protein C20orf96; Chromosome 20 open reading frame 96.
CLDN7 protein networkhttps://string-db.org/network/9606.ENSP00000353475Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family.
ZNF460 protein networkhttps://string-db.org/network/9606.ENSP00000353491Zinc finger protein 460; May be involved in transcriptional regulation.
LZTS3 protein networkhttps://string-db.org/network/9606.ENSP00000353496Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belong [...]
MAP2 protein networkhttps://string-db.org/network/9606.ENSP00000353508Microtubule-associated protein 2; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubule [...]
PARP9 protein networkhttps://string-db.org/network/9606.ENSP00000353512Protein mono-ADP-ribosyltransferase PARP9; ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediat [...]
OR2W3 protein networkhttps://string-db.org/network/9606.ENSP00000353516Olfactory receptor 2W3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ANKS1A protein networkhttps://string-db.org/network/9606.ENSP00000353518Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction [...]
OR5B21 protein networkhttps://string-db.org/network/9606.ENSP00000353537Olfactory receptor 5B21; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
LRRCC1 protein networkhttps://string-db.org/network/9606.ENSP00000353538Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis.
SLC35F1 protein networkhttps://string-db.org/network/9606.ENSP00000353557Solute carrier family 35 member F1; Putative solute transporter.
EIF2B3 protein networkhttps://string-db.org/network/9606.ENSP00000353575Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family.
NRP2 protein networkhttps://string-db.org/network/9606.ENSP00000353582Neuropilin-2; High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.
MYH10 protein networkhttps://string-db.org/network/9606.ENSP00000353590Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I coll [...]
SULT1A4 protein networkhttps://string-db.org/network/9606.ENSP00000353600Sulfotransferase 1A3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as [...]
DSC3 protein networkhttps://string-db.org/network/9606.ENSP00000353608Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...]
CLPSL2 protein networkhttps://string-db.org/network/9606.ENSP00000353639Colipase-like protein 2; Colipase like 2.
PLEKHG4 protein networkhttps://string-db.org/network/9606.ENSP00000353646Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.
FABP12 protein networkhttps://string-db.org/network/9606.ENSP00000353650Fatty acid-binding protein 12; May play a role in lipid transport.
ZNF528 protein networkhttps://string-db.org/network/9606.ENSP00000353652Zinc finger protein 528; May be involved in transcriptional regulation.
COL4A2 protein networkhttps://string-db.org/network/9606.ENSP00000353654Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
SPOCD1 protein networkhttps://string-db.org/network/9606.ENSP00000353670SPOC domain containing 1.
CCDC144A protein networkhttps://string-db.org/network/9606.ENSP00000353717Coiled-coil domain containing 144A.
CES1 protein networkhttps://string-db.org/network/9606.ENSP00000353720Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity [...]
DPP4 protein networkhttps://string-db.org/network/9606.ENSP00000353731Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive r [...]
CLIP3 protein networkhttps://string-db.org/network/9606.ENSP00000353732CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and [...]
PLAGL1 protein networkhttps://string-db.org/network/9606.ENSP00000353734Zinc finger protein PLAGL1; Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
TOPORS protein networkhttps://string-db.org/network/9606.ENSP00000353735E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apopto [...]
PCMTD1 protein networkhttps://string-db.org/network/9606.ENSP00000353739protein-L-isoaspartate O-methyltransferase domain containing 1.
ETF1 protein networkhttps://string-db.org/network/9606.ENSP00000353741Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the tran [...]
KRTAP26-1 protein networkhttps://string-db.org/network/9606.ENSP00000353742Keratin-associated protein 26-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
MMP17 protein networkhttps://string-db.org/network/9606.ENSP00000353767Matrix metalloproteinase-17; Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth f [...]
SCAF1 protein networkhttps://string-db.org/network/9606.ENSP00000353769Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing.
RRM2 protein networkhttps://string-db.org/network/9606.ENSP00000353770Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. In [...]
TPPP protein networkhttps://string-db.org/network/9606.ENSP00000353785Tubulin polymerization-promoting protein; Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation fac [...]
SLC6A9 protein networkhttps://string-db.org/network/9606.ENSP00000353791Sodium- and chloride-dependent glycine transporter 1; Terminates the action of glycine by its high affinity sodium- dependent reuptake into presynaptic terminals. May play a role in regulation of [...]
WDHD1 protein networkhttps://string-db.org/network/9606.ENSP00000353793WD repeat and HMG-box DNA-binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA [...]
FBXL22 protein networkhttps://string-db.org/network/9606.ENSP00000353794F-box and leucine-rich protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-acti [...]
ANKRD53 protein networkhttps://string-db.org/network/9606.ENSP00000353796Ankyrin repeat domain-containing protein 53; Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization.
PIM3 protein networkhttps://string-db.org/network/9606.ENSP00000353824Serine/threonine-protein kinase pim-3; Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigene [...]
LONP1 protein networkhttps://string-db.org/network/9606.ENSP00000353826Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-l [...]
DCLK1 protein networkhttps://string-db.org/network/9606.ENSP00000353846Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in function [...]
ITGB1BP1 protein networkhttps://string-db.org/network/9606.ENSP00000353850Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alph [...]
C15orf39 protein networkhttps://string-db.org/network/9606.ENSP00000353854Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39.
ZNF148 protein networkhttps://string-db.org/network/9606.ENSP00000353863Zinc finger protein 148; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhanc [...]
PAK3 protein networkhttps://string-db.org/network/9606.ENSP00000353864Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cy [...]
PCED1A protein networkhttps://string-db.org/network/9606.ENSP00000353868PC-esterase domain containing 1A; Belongs to the PC-esterase family.
TLR9 protein networkhttps://string-db.org/network/9606.ENSP00000353874Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific [...]
LGALS14 protein networkhttps://string-db.org/network/9606.ENSP00000353893Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.
CSNK1G3 protein networkhttps://string-db.org/network/9606.ENSP00000353904Casein kinase I isoform gamma-3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...]
FUT8 protein networkhttps://string-db.org/network/9606.ENSP00000353910Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 f [...]
HTR4 protein networkhttps://string-db.org/network/9606.ENSP000003539155-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...]
ADARB1 protein networkhttps://string-db.org/network/9606.ENSP00000353920Double-stranded RNA-specific editase 1; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene express [...]
ZNF711 protein networkhttps://string-db.org/network/9606.ENSP00000353922Zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demet [...]
DRC7 protein networkhttps://string-db.org/network/9606.ENSP00000353942Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dist [...]
CLIC6 protein networkhttps://string-db.org/network/9606.ENSP00000353959Chloride intracellular channel protein 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride [...]
KRTAP12-2 protein networkhttps://string-db.org/network/9606.ENSP00000354001Keratin-associated protein 12-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
GYPA protein networkhttps://string-db.org/network/9606.ENSP00000354003Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group recep [...]
TRPM6 protein networkhttps://string-db.org/network/9606.ENSP00000354006Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial [...]
BSCL2 protein networkhttps://string-db.org/network/9606.ENSP00000354032Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lip [...]
UBAP2 protein networkhttps://string-db.org/network/9606.ENSP00000354039Ubiquitin associated protein 2.
GTPBP4 protein networkhttps://string-db.org/network/9606.ENSP00000354040Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
GLT8D2 protein networkhttps://string-db.org/network/9606.ENSP00000354053Glycosyltransferase 8 domain containing 2.
SCUBE1 protein networkhttps://string-db.org/network/9606.ENSP00000354080Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
ANKHD1 protein networkhttps://string-db.org/network/9606.ENSP00000354085Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapop [...]
SIGLEC14 protein networkhttps://string-db.org/network/9606.ENSP00000354090Sialic acid-binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Belongs to the immunoglobulin superfamily. SIGLEC ( [...]
GNL3L protein networkhttps://string-db.org/network/9606.ENSP00000354091Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination an [...]
RGS22 protein networkhttps://string-db.org/network/9606.ENSP00000354109Regulator of G-protein signaling 22; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
DNAJC5 protein networkhttps://string-db.org/network/9606.ENSP00000354111DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calci [...]
EIF3B protein networkhttps://string-db.org/network/9606.ENSP00000354125Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...]
MTHFSD protein networkhttps://string-db.org/network/9606.ENSP00000354152Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing.
ERC1 protein networkhttps://string-db.org/network/9606.ENSP00000354158ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at t [...]
FAM110A protein networkhttps://string-db.org/network/9606.ENSP00000354163Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family.
UBE2Z protein networkhttps://string-db.org/network/9606.ENSP00000354201Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involv [...]
TOMM20L protein networkhttps://string-db.org/network/9606.ENSP00000354204TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like.
ZNF219 protein networkhttps://string-db.org/network/9606.ENSP00000354206Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG- 3'. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regula [...]
NTRK3 protein networkhttps://string-db.org/network/9606.ENSP00000354207NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activ [...]
HS3ST3B1 protein networkhttps://string-db.org/network/9606.ENSP00000354213Heparan sulfate glucosamine 3-O-sulfotransferase 3B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosam [...]
PPP1R13L protein networkhttps://string-db.org/network/9606.ENSP00000354218RelA-associated inhibitor; Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV- [...]
MPC1 protein networkhttps://string-db.org/network/9606.ENSP00000354223Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
C11orf80 protein networkhttps://string-db.org/network/9606.ENSP00000354227Type 2 DNA topoisomerase 6 subunit B-like; [Isoform 3]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that for [...]
NCKAP1 protein networkhttps://string-db.org/network/9606.ENSP00000354251Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Act [...]
CPZ protein networkhttps://string-db.org/network/9606.ENSP00000354255Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during proh [...]
PRSS3 protein networkhttps://string-db.org/network/9606.ENSP00000354280Trypsin-3; Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. Belongs to the peptidase S1 family.
CTRB1 protein networkhttps://string-db.org/network/9606.ENSP00000354294Chymotrypsinogen B1; Belongs to the peptidase S1 family.
ZSCAN12 protein networkhttps://string-db.org/network/9606.ENSP00000354305Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation.
TMEM239 protein networkhttps://string-db.org/network/9606.ENSP00000354312Transmembrane protein 239.
HAO2 protein networkhttps://string-db.org/network/9606.ENSP00000354314Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
MPEG1 protein networkhttps://string-db.org/network/9606.ENSP00000354335Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by inserting into the bacterial surface to form pores (By similarity). By breachi [...]
UBA3 protein networkhttps://string-db.org/network/9606.ENSP00000354340NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter lin [...]
MATR3-2 protein networkhttps://string-db.org/network/9606.ENSP00000354346Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a ro [...]
GSTM3 protein networkhttps://string-db.org/network/9606.ENSP00000354357Glutathione S-transferase Mu 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous [...]
LAMC3 protein networkhttps://string-db.org/network/9606.ENSP00000354360Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
RFWD3 protein networkhttps://string-db.org/network/9606.ENSP00000354361E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage [...]
RAB25 protein networkhttps://string-db.org/network/9606.ENSP00000354376Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of [...]
ZNF37A protein networkhttps://string-db.org/network/9606.ENSP00000354377Zinc finger protein 37A; May be involved in transcriptional regulation.
STAT1 protein networkhttps://string-db.org/network/9606.ENSP00000354394Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other c [...]
SLFN12L protein networkhttps://string-db.org/network/9606.ENSP00000354412Schlafen family member 12 like; Belongs to the Schlafen family.
ZNF627 protein networkhttps://string-db.org/network/9606.ENSP00000354414Zinc finger protein 627; May be involved in transcriptional regulation.
CCL28 protein networkhttps://string-db.org/network/9606.ENSP00000354416C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
ANKRD30A protein networkhttps://string-db.org/network/9606.ENSP00000354432Ankyrin repeat domain 30A.
TMEM184B protein networkhttps://string-db.org/network/9606.ENSP00000354441Transmembrane protein 184B; May activate the MAP kinase signaling pathway. Belongs to the TMEM184 family.
IQGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000354451Ras GTPase-activating-like protein IQGAP3; IQ motif containing GTPase activating protein 3.
ZFP2 protein networkhttps://string-db.org/network/9606.ENSP00000354453Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance.
C8A protein networkhttps://string-db.org/network/9606.ENSP00000354458Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of t [...]
PHETA1 protein networkhttps://string-db.org/network/9606.ENSP00000354461Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.
CYB5R3 protein networkhttps://string-db.org/network/9606.ENSP00000354468NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
SREBF2 protein networkhttps://string-db.org/network/9606.ENSP00000354476Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to [...]
DLX1 protein networkhttps://string-db.org/network/9606.ENSP00000354478Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the tra [...]
BRINP2 protein networkhttps://string-db.org/network/9606.ENSP00000354481BMP/retinoic acid-inducible neural-specific protein 2; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
DUSP27 protein networkhttps://string-db.org/network/9606.ENSP00000354483Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
ZEB1 protein networkhttps://string-db.org/network/9606.ENSP00000354487Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending [...]
TNNI1 protein networkhttps://string-db.org/network/9606.ENSP00000354488Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase act [...]
ATP1A2 protein networkhttps://string-db.org/network/9606.ENSP00000354490Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...]
FAN1 protein networkhttps://string-db.org/network/9606.ENSP00000354497Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair [...]
PHLDB1 protein networkhttps://string-db.org/network/9606.ENSP00000354498Pleckstrin homology like domain family B member 1.
MT-CO1 protein networkhttps://string-db.org/network/9606.ENSP00000354499Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain [...]
ZNF277 protein networkhttps://string-db.org/network/9606.ENSP00000354501Zinc finger protein 277; May be involved in transcriptional regulation; Belongs to the ZNF277 family.
ASTN2 protein networkhttps://string-db.org/network/9606.ENSP00000354504Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular tra [...]
COMT protein networkhttps://string-db.org/network/9606.ENSP00000354511Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certa [...]
ZNF830 protein networkhttps://string-db.org/network/9606.ENSP00000354518Zinc finger protein 830; May play a role in pre-mRNA splicing as component of the spliceosome. Acts as an important regulator of the cell cycle that participates in the maintenance of genome inte [...]
TOP1 protein networkhttps://string-db.org/network/9606.ENSP00000354522DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA dup [...]
MRPL24 protein networkhttps://string-db.org/network/9606.ENSP00000354525Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family.
PNP protein networkhttps://string-db.org/network/9606.ENSP00000354532Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formati [...]
ASTN1 protein networkhttps://string-db.org/network/9606.ENSP00000354536Astrotactin-1; Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migr [...]
TSC22D2 protein networkhttps://string-db.org/network/9606.ENSP00000354543TSC22 domain family member 2.
ZFP69B protein networkhttps://string-db.org/network/9606.ENSP00000354547Zinc finger protein 69 homolog B; May be involved in transcriptional regulation. Essential for Golgi structural integrity.
GLMP protein networkhttps://string-db.org/network/9606.ENSP00000354553Glycosylated lysosomal membrane protein; Belongs to the GLMP family.
MT-CYB protein networkhttps://string-db.org/network/9606.ENSP00000354554Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates ele [...]
MTOR protein networkhttps://string-db.org/network/9606.ENSP00000354558Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, [...]
KIFAP3 protein networkhttps://string-db.org/network/9606.ENSP00000354560Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeri [...]
CD3E protein networkhttps://string-db.org/network/9606.ENSP00000354566T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting c [...]
RNF121 protein networkhttps://string-db.org/network/9606.ENSP00000354571Ring finger protein 121; Belongs to the RNF121 family.
MACF1 protein networkhttps://string-db.org/network/9606.ENSP00000354573Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtu [...]
MRPL21 protein networkhttps://string-db.org/network/9606.ENSP00000354580Mitochondrial ribosomal protein L21.
GPX6 protein networkhttps://string-db.org/network/9606.ENSP00000354581Glutathione peroxidase 6.
MFAP3L protein networkhttps://string-db.org/network/9606.ENSP00000354583Microfibrillar-associated protein 3-like; May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.
SFT2D1 protein networkhttps://string-db.org/network/9606.ENSP00000354590Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.
DENND4B protein networkhttps://string-db.org/network/9606.ENSP00000354597DENN domain-containing protein 4B; Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab proteins into their a [...]
FZD5 protein networkhttps://string-db.org/network/9606.ENSP00000354607Frizzled-5; Receptor for Wnt proteins. Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpresse [...]
PPT2 protein networkhttps://string-db.org/network/9606.ENSP00000354608Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and [...]
AMY2B protein networkhttps://string-db.org/network/9606.ENSP00000354610Amylase alpha 2B; Belongs to the glycosyl hydrolase 13 family.
PTGS1 protein networkhttps://string-db.org/network/9606.ENSP00000354612Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in t [...]
SMURF1 protein networkhttps://string-db.org/network/9606.ENSP00000354621E3 ubiquitin-protein ligase SMURF1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor- [...]
RUNDC1 protein networkhttps://string-db.org/network/9606.ENSP00000354622RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.
WHRN protein networkhttps://string-db.org/network/9606.ENSP00000354623Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. In [...]
MT-ATP6 protein networkhttps://string-db.org/network/9606.ENSP00000354632ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated [...]
TAF11 protein networkhttps://string-db.org/network/9606.ENSP00000354633Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectivel [...]
DIO1 protein networkhttps://string-db.org/network/9606.ENSP00000354643Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in [...]
GPATCH3 protein networkhttps://string-db.org/network/9606.ENSP00000354645G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migratio [...]
MAGT1 protein networkhttps://string-db.org/network/9606.ENSP00000354649Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked o [...]
NPY1R protein networkhttps://string-db.org/network/9606.ENSP00000354652Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] [...]
MAGEC2 protein networkhttps://string-db.org/network/9606.ENSP00000354660Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM [...]
MT-ND6 protein networkhttps://string-db.org/network/9606.ENSP00000354665NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
MINDY1 protein networkhttps://string-db.org/network/9606.ENSP00000354669Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for l [...]
MAST2 protein networkhttps://string-db.org/network/9606.ENSP00000354671Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modula [...]
GPX7 protein networkhttps://string-db.org/network/9606.ENSP00000354677Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects agai [...]
OPA1 protein networkhttps://string-db.org/network/9606.ENSP00000354681Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondr [...]
ZNF630 protein networkhttps://string-db.org/network/9606.ENSP00000354683Zinc finger protein 630; May be involved in transcriptional regulation.
ZNF652 protein networkhttps://string-db.org/network/9606.ENSP00000354686Zinc finger protein 652; Functions as a transcriptional repressor.
MT-ND1 protein networkhttps://string-db.org/network/9606.ENSP00000354687NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
DENND10 protein networkhttps://string-db.org/network/9606.ENSP00000354688DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly t [...]
SLC39A13 protein networkhttps://string-db.org/network/9606.ENSP00000354689Zinc transporter ZIP13; Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
FCRL5 protein networkhttps://string-db.org/network/9606.ENSP00000354691Fc receptor-like protein 5; May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role i [...]
AKAP13 protein networkhttps://string-db.org/network/9606.ENSP00000354718A-kinase anchor protein 13; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response [...]
SMC3 protein networkhttps://string-db.org/network/9606.ENSP00000354720Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous [...]
SLC26A1 protein networkhttps://string-db.org/network/9606.ENSP00000354721Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (B [...]
EIF1AY protein networkhttps://string-db.org/network/9606.ENSP00000354722Eukaryotic translation initiation factor 1A, Y-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding [...]
H2BW1 protein networkhttps://string-db.org/network/9606.ENSP00000354723Histone H2B type W-T; Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, [...]
PCGF3 protein networkhttps://string-db.org/network/9606.ENSP00000354724Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes [...]
MT-ND4L protein networkhttps://string-db.org/network/9606.ENSP00000354728NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required fo [...]
PRR5-ARHGAP8 protein networkhttps://string-db.org/network/9606.ENSP00000354732PRR5-ARHGAP8 readthrough.
SBNO2 protein networkhttps://string-db.org/network/9606.ENSP00000354733Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhanc [...]
RPL12 protein networkhttps://string-db.org/network/9606.ENSP0000035473960S ribosomal protein L12; Binds directly to 26S ribosomal RNA.
IPO9 protein networkhttps://string-db.org/network/9606.ENSP00000354742Importin-9; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...]
COA3 protein networkhttps://string-db.org/network/9606.ENSP00000354762Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, t [...]
MVB12B protein networkhttps://string-db.org/network/9606.ENSP00000354772Multivesicular body subunit 12B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bod [...]
SPRYD7 protein networkhttps://string-db.org/network/9606.ENSP00000354774SPRY domain containing 7.
PJA2 protein networkhttps://string-db.org/network/9606.ENSP00000354775E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulator [...]
TBKBP1 protein networkhttps://string-db.org/network/9606.ENSP00000354777TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.
CNTNAP2 protein networkhttps://string-db.org/network/9606.ENSP00000354778Contactin-associated protein-like 2; Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical fo [...]
CD247 protein networkhttps://string-db.org/network/9606.ENSP00000354782T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cell [...]
DCTN1 protein networkhttps://string-db.org/network/9606.ENSP00000354791Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein [...]
ZNF521 protein networkhttps://string-db.org/network/9606.ENSP00000354794Zinc finger protein 521; Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartmen [...]
SPOUT1 protein networkhttps://string-db.org/network/9606.ENSP00000354812Putative methyltransferase C9orf114; Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote [...]
MT-ND5 protein networkhttps://string-db.org/network/9606.ENSP00000354813NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
XAF1 protein networkhttps://string-db.org/network/9606.ENSP00000354822XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and in [...]
CALD1 protein networkhttps://string-db.org/network/9606.ENSP00000354826Caldesmon; Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments [...]
SGMS1 protein networkhttps://string-db.org/network/9606.ENSP00000354829Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, [...]
DDIT4L protein networkhttps://string-db.org/network/9606.ENSP00000354830DNA damage-inducible transcript 4-like protein; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
ARHGEF2 protein networkhttps://string-db.org/network/9606.ENSP00000354837Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendr [...]
TOX protein networkhttps://string-db.org/network/9606.ENSP00000354842Thymocyte selection-associated high mobility group box protein TOX; Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell devel [...]
KIFBP protein networkhttps://string-db.org/network/9606.ENSP00000354848KIF-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development; Belongs to the KIF-binding pr [...]
OGA protein networkhttps://string-db.org/network/9606.ENSP00000354850Protein O-GlcNAcase; [Isoform 1]: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitrophe [...]
NFE2L1 protein networkhttps://string-db.org/network/9606.ENSP00000354855Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stres [...]
DRD2 protein networkhttps://string-db.org/network/9606.ENSP00000354859D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.
PPEF1 protein networkhttps://string-db.org/network/9606.ENSP00000354871Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; Belongs to the PPP phosphatase fami [...]
SEPTIN4 protein networkhttps://string-db.org/network/9606.ENSP00000354874Uncharacterized protein C17orf47; Septin 4.
MT-CO2 protein networkhttps://string-db.org/network/9606.ENSP00000354876Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain [...]
KIF21A protein networkhttps://string-db.org/network/9606.ENSP00000354878Kinesin-like protein KIF21A; Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
RASSF9 protein networkhttps://string-db.org/network/9606.ENSP00000354884Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells.
SLC25A47 protein networkhttps://string-db.org/network/9606.ENSP00000354886Solute carrier family 25 member 47; Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential.
CCDC152 protein networkhttps://string-db.org/network/9606.ENSP00000354888Coiled-coil domain containing 152.
FAM163A protein networkhttps://string-db.org/network/9606.ENSP00000354891Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family.
GJB1 protein networkhttps://string-db.org/network/9606.ENSP00000354900Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
CXCL9 protein networkhttps://string-db.org/network/9606.ENSP00000354901C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to [...]
NRG2 protein networkhttps://string-db.org/network/9606.ENSP00000354910Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine [...]
TIFA protein networkhttps://string-db.org/network/9606.ENSP00000354911TRAF-interacting protein with FHA domain-containing protein A; Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pa [...]
MAGEE1 protein networkhttps://string-db.org/network/9606.ENSP00000354912Melanoma-associated antigen E1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...]
CDC14A protein networkhttps://string-db.org/network/9606.ENSP00000354916Dual specificity protein phosphatase CDC14A; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early [...]
TOGARAM1 protein networkhttps://string-db.org/network/9606.ENSP00000354917TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cil [...]
VEPH1 protein networkhttps://string-db.org/network/9606.ENSP00000354919Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear [...]
EEF1AKNMT protein networkhttps://string-db.org/network/9606.ENSP00000354920eEF1A lysine and N-terminal methyltransferase; Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore invo [...]
DMD protein networkhttps://string-db.org/network/9606.ENSP00000354923Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neurom [...]
MAP3K3 protein networkhttps://string-db.org/network/9606.ENSP00000354927Mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
NOTCH2NLA protein networkhttps://string-db.org/network/9606.ENSP00000354929Notch homolog 2 N-terminal-like protein A; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling [...]
TLR1 protein networkhttps://string-db.org/network/9606.ENSP00000354932Toll-like receptor 1; Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate i [...]
CAPZA2 protein networkhttps://string-db.org/network/9606.ENSP00000354947F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...]
GAB2 protein networkhttps://string-db.org/network/9606.ENSP00000354952GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate mu [...]
SMC5 protein networkhttps://string-db.org/network/9606.ENSP00000354957Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may pro [...]
FAM189B protein networkhttps://string-db.org/network/9606.ENSP00000354958Protein FAM189B; Family with sequence similarity 189 member B.
COLGALT2 protein networkhttps://string-db.org/network/9606.ENSP00000354960Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family.
MT-ND4 protein networkhttps://string-db.org/network/9606.ENSP00000354961NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
ZNF318 protein networkhttps://string-db.org/network/9606.ENSP00000354964Zinc finger protein 318; [Isoform 2]: Acts as a transcriptional corepressor for AR- mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and, in partic [...]
NAA35 protein networkhttps://string-db.org/network/9606.ENSP00000354972N-alpha-acetyltransferase 35, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Invol [...]
MT-CO3 protein networkhttps://string-db.org/network/9606.ENSP00000354982Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain [...]
ALPK2 protein networkhttps://string-db.org/network/9606.ENSP00000354991Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte [...]
ABCG1 protein networkhttps://string-db.org/network/9606.ENSP00000354995ATP-binding cassette sub-family G member 1; Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transpo [...]
POU3F3 protein networkhttps://string-db.org/network/9606.ENSP00000355001POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the [...]
ILF2 protein networkhttps://string-db.org/network/9606.ENSP00000355011Interleukin enhancer-binding factor 2; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It [...]
CTR9 protein networkhttps://string-db.org/network/9606.ENSP00000355013RNA polymerase-associated protein CTR9 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of dev [...]
PJA1 protein networkhttps://string-db.org/network/9606.ENSP00000355014E3 ubiquitin-protein ligase Praja-1; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May b [...]
TEDC2 protein networkhttps://string-db.org/network/9606.ENSP00000355022Tubulin epsilon and delta complex protein 2; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability.
ARHGEF15 protein networkhttps://string-db.org/network/9606.ENSP00000355026Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synap [...]
DZIP3 protein networkhttps://string-db.org/network/9606.ENSP00000355028E3 ubiquitin-protein ligase DZIP3; E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 [...]
MT-ND2 protein networkhttps://string-db.org/network/9606.ENSP00000355046NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
CTNNBL1 protein networkhttps://string-db.org/network/9606.ENSP00000355050Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediat [...]
TAF13 protein networkhttps://string-db.org/network/9606.ENSP00000355051Transcription initiation factor TFIID subunit 13; Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of [...]
ZSCAN20 protein networkhttps://string-db.org/network/9606.ENSP00000355053Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ARHGEF10L protein networkhttps://string-db.org/network/9606.ENSP00000355060Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.
SHISA4 protein networkhttps://string-db.org/network/9606.ENSP00000355064Protein shisa-4; Shisa family member 4.
NSMCE1 protein networkhttps://string-db.org/network/9606.ENSP00000355077Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transf [...]
PCDH18 protein networkhttps://string-db.org/network/9606.ENSP00000355082Protocadherin-18; Potential calcium-dependent cell-adhesion protein.
MSRB1 protein networkhttps://string-db.org/network/9606.ENSP00000355084Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result [...]
ARHGAP11A protein networkhttps://string-db.org/network/9606.ENSP00000355090Rho GTPase activating protein 11A.
QKI protein networkhttps://string-db.org/network/9606.ENSP00000355094Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY- 3' RNA core sequence. Regulates target mRNA stability. In addition, acts by [...]
SMOC1 protein networkhttps://string-db.org/network/9606.ENSP00000355110SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
DCAF12 protein networkhttps://string-db.org/network/9606.ENSP00000355114DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
ITPRIPL1 protein networkhttps://string-db.org/network/9606.ENSP00000355121Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIP like 1.
KRT19 protein networkhttps://string-db.org/network/9606.ENSP00000355124Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Belongs [...]
NOS1AP protein networkhttps://string-db.org/network/9606.ENSP00000355133Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex [...]
HOXB1 protein networkhttps://string-db.org/network/9606.ENSP00000355140Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
SELENON protein networkhttps://string-db.org/network/9606.ENSP00000355141Selenoprotein N; [Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER [...]
GRIN3A protein networkhttps://string-db.org/network/9606.ENSP00000355155Glutamate receptor ionotropic, NMDA 3A; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivi [...]
SUCNR1 protein networkhttps://string-db.org/network/9606.ENSP00000355156Succinate receptor 1; Receptor for succinate.
FCRL2 protein networkhttps://string-db.org/network/9606.ENSP00000355157Fc receptor-like protein 2; May have an regulatory role in normal and neoplastic B cell development.
TIGD4 protein networkhttps://string-db.org/network/9606.ENSP00000355162Tigger transposable element derived 4.
LRRC10 protein networkhttps://string-db.org/network/9606.ENSP00000355166Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function.
HORMAD1 protein networkhttps://string-db.org/network/9606.ENSP00000355167HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks ( [...]
COL6A1 protein networkhttps://string-db.org/network/9606.ENSP00000355180Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein.
DCLRE1A protein networkhttps://string-db.org/network/9606.ENSP00000355185DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle p [...]
LRRTM3 protein networkhttps://string-db.org/network/9606.ENSP00000355187Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in t [...]
CACNA1S protein networkhttps://string-db.org/network/9606.ENSP00000355192Voltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calci [...]
ASB12 protein networkhttps://string-db.org/network/9606.ENSP00000355195Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
MAGEB3 protein networkhttps://string-db.org/network/9606.ENSP00000355198Melanoma-associated antigen B3; MAGE family member B3.
FAM110B protein networkhttps://string-db.org/network/9606.ENSP00000355204Protein FAM110B; May be involved in tumor progression.
MT-ND3 protein networkhttps://string-db.org/network/9606.ENSP00000355206NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...]
HMGN2 protein networkhttps://string-db.org/network/9606.ENSP00000355228Non-histone chromosomal protein HMG-17; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which [...]
BECN1 protein networkhttps://string-db.org/network/9606.ENSP00000355231Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to [...]
CDC42BPB protein networkhttps://string-db.org/network/9606.ENSP00000355237Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and [...]
TEX45 protein networkhttps://string-db.org/network/9606.ENSP00000355241Testis-expressed protein 45; Testis expressed 45.
PAX9 protein networkhttps://string-db.org/network/9606.ENSP00000355245Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as dista [...]
E2F2 protein networkhttps://string-db.org/network/9606.ENSP00000355249Transcription factor E2F2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of gen [...]
KIAA0753 protein networkhttps://string-db.org/network/9606.ENSP00000355250Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of [...]
ZNF511 protein networkhttps://string-db.org/network/9606.ENSP00000355251Zinc finger protein 511; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PPP1R14C protein networkhttps://string-db.org/network/9606.ENSP00000355260Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA.
SMG5 protein networkhttps://string-db.org/network/9606.ENSP00000355261Protein SMG5; Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA [...]
MT-ATP8 protein networkhttps://string-db.org/network/9606.ENSP00000355265ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated [...]
CNOT7 protein networkhttps://string-db.org/network/9606.ENSP00000355279CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalyti [...]
TSEN15 protein networkhttps://string-db.org/network/9606.ENSP00000355299tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. I [...]
KRTAP1-5 protein networkhttps://string-db.org/network/9606.ENSP00000355302Keratin-associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
MOK protein networkhttps://string-db.org/network/9606.ENSP00000355304MAPK/MAK/MRK overlapping kinase; Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent [...]
C1orf174 protein networkhttps://string-db.org/network/9606.ENSP00000355306UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family.
HACD1 protein networkhttps://string-db.org/network/9606.ENSP00000355308Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzy [...]
RPL39 protein networkhttps://string-db.org/network/9606.ENSP00000355315Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family.
GRM3 protein networkhttps://string-db.org/network/9606.ENSP00000355316Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
CIPC protein networkhttps://string-db.org/network/9606.ENSP00000355319CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulat [...]
PSMB5 protein networkhttps://string-db.org/network/9606.ENSP00000355325Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
TGM2 protein networkhttps://string-db.org/network/9606.ENSP00000355330Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.
APOBEC3C protein networkhttps://string-db.org/network/9606.ENSP00000355340DNA dC->dU-editing enzyme APOBEC-3C; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
SOX15 protein networkhttps://string-db.org/network/9606.ENSP00000355354Protein SOX-15; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity). Acts as a transcriptional activator and repressor (By similarity). Binds synergisti [...]
CD47 protein networkhttps://string-db.org/network/9606.ENSP00000355361Leukocyte surface antigen CD47; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory fo [...]
CNTF protein networkhttps://string-db.org/network/9606.ENSP00000355370Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
OSGIN1 protein networkhttps://string-db.org/network/9606.ENSP00000355374Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death.
AKR7A3 protein networkhttps://string-db.org/network/9606.ENSP00000355377Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against t [...]
SLC26A11 protein networkhttps://string-db.org/network/9606.ENSP00000355384Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high end [...]
R3HDM4 protein networkhttps://string-db.org/network/9606.ENSP00000355385R3H domain containing 4.
SCAMP5 protein networkhttps://string-db.org/network/9606.ENSP00000355387Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE ma [...]
MPHOSPH8 protein networkhttps://string-db.org/network/9606.ENSP00000355388M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic r [...]
LRIG2 protein networkhttps://string-db.org/network/9606.ENSP00000355396Leucine rich repeats and immunoglobulin like domains 2.
ISLR2 protein networkhttps://string-db.org/network/9606.ENSP00000355402Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development.
PCDH11Y protein networkhttps://string-db.org/network/9606.ENSP00000355419Protocadherin 11 Y-linked.
GAGE2A protein networkhttps://string-db.org/network/9606.ENSP00000355421G antigen 2A.
SH3BP5L protein networkhttps://string-db.org/network/9606.ENSP00000355428SH3 domain-binding protein 5-like; Functions as guanine nucleotide exchange factor (GEF) for RAB11A.
OR2T1 protein networkhttps://string-db.org/network/9606.ENSP00000355430Olfactory receptor 2T1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T4 protein networkhttps://string-db.org/network/9606.ENSP00000355431Olfactory receptor 2T4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2M5 protein networkhttps://string-db.org/network/9606.ENSP00000355432Olfactory receptor 2M5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TRIM58 protein networkhttps://string-db.org/network/9606.ENSP00000355437E3 ubiquitin-protein ligase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1 [...]
OR14A2 protein networkhttps://string-db.org/network/9606.ENSP00000355441Olfactory receptor 14A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF670 protein networkhttps://string-db.org/network/9606.ENSP00000355459Zinc finger protein 670; May be involved in transcriptional regulation.
AHCTF1 protein networkhttps://string-db.org/network/9606.ENSP00000355465Protein ELYS; Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chro [...]
SCCPDH protein networkhttps://string-db.org/network/9606.ENSP00000355467Saccharopine dehydrogenase-like oxidoreductase; Saccharopine dehydrogenase; Belongs to the saccharopine dehydrogenase family.
CNST protein networkhttps://string-db.org/network/9606.ENSP00000355470Consortin; Required for targeting of connexins to the plasma membrane.
TFB2M protein networkhttps://string-db.org/network/9606.ENSP00000355471Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin ne [...]
EFCAB2 protein networkhttps://string-db.org/network/9606.ENSP00000355480Dynein regulatory complex protein 8; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dis [...]
COX20 protein networkhttps://string-db.org/network/9606.ENSP00000355486Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chape [...]
CATSPERE protein networkhttps://string-db.org/network/9606.ENSP00000355492Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for spe [...]
ADSS2 protein networkhttps://string-db.org/network/9606.ENSP00000355493Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosy [...]
SDCCAG8 protein networkhttps://string-db.org/network/9606.ENSP00000355499Serologically defined colon cancer antigen 8; Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Plays also an essential role in ciliogenesis and s [...]
CEP170 protein networkhttps://string-db.org/network/9606.ENSP00000355500Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly. Belongs to the CEP170 family.
EXO1 protein networkhttps://string-db.org/network/9606.ENSP00000355506Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-c [...]
WDR64 protein networkhttps://string-db.org/network/9606.ENSP00000355510WD repeat domain 64.
CHML protein networkhttps://string-db.org/network/9606.ENSP00000355511Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents t [...]
OPN3 protein networkhttps://string-db.org/network/9606.ENSP00000355512Opsin-3; May play a role in encephalic photoreception; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
KMO protein networkhttps://string-db.org/network/9606.ENSP00000355517Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor an [...]
FH protein networkhttps://string-db.org/network/9606.ENSP00000355518Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in other species have demonstrated that specific isoforms of this p [...]
RGS7 protein networkhttps://string-db.org/network/9606.ENSP00000355523Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...]
RYR2 protein networkhttps://string-db.org/network/9606.ENSP00000355533Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. [...]
MTR protein networkhttps://string-db.org/network/9606.ENSP00000355536Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor us [...]
ACTN2 protein networkhttps://string-db.org/network/9606.ENSP00000355537Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
HEATR1 protein networkhttps://string-db.org/network/9606.ENSP00000355541HEAT repeat-containing protein 1, N-terminally processed; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcripti [...]
GPR137B protein networkhttps://string-db.org/network/9606.ENSP00000355551Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth fact [...]
B3GALNT2 protein networkhttps://string-db.org/network/9606.ENSP00000355559UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. [...]
TOMM20 protein networkhttps://string-db.org/network/9606.ENSP00000355566Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preprot [...]
IRF2BP2 protein networkhttps://string-db.org/network/9606.ENSP00000355568Interferon regulatory factor 2-binding protein 2; Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. Represses th [...]
COA6 protein networkhttps://string-db.org/network/9606.ENSP00000355574Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV a [...]
SLC35F3 protein networkhttps://string-db.org/network/9606.ENSP00000355577Putative thiamine transporter SLC35F3; May be a thiamine transporter; Belongs to the SLC35F solute transporter family.
KCNK1 protein networkhttps://string-db.org/network/9606.ENSP00000355580Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but [...]
MAP3K21 protein networkhttps://string-db.org/network/9606.ENSP00000355583Mitogen-activated protein kinase kinase kinase 21; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
NTPCR protein networkhttps://string-db.org/network/9606.ENSP00000355587Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency. Belongs to the THEP1 NT [...]
SIPA1L2 protein networkhttps://string-db.org/network/9606.ENSP00000355589Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2.
TSNAX protein networkhttps://string-db.org/network/9606.ENSP00000355599Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
EGLN1 protein networkhttps://string-db.org/network/9606.ENSP00000355601Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...]
EXOC8 protein networkhttps://string-db.org/network/9606.ENSP00000355605Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the EXO84 family.
GNPAT protein networkhttps://string-db.org/network/9606.ENSP00000355607Glyceronephosphate O-acyltransferase.
C1orf131 protein networkhttps://string-db.org/network/9606.ENSP00000355609Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131.
TRIM67 protein networkhttps://string-db.org/network/9606.ENSP00000355613Tripartite motif containing 67; Belongs to the TRIM/RBCC family.
FAM89A protein networkhttps://string-db.org/network/9606.ENSP00000355614Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family.
TTC13 protein networkhttps://string-db.org/network/9606.ENSP00000355621Tetratricopeptide repeat domain 13.
C1orf198 protein networkhttps://string-db.org/network/9606.ENSP00000355623Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198.
AGT protein networkhttps://string-db.org/network/9606.ENSP00000355627Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone r [...]
COG2 protein networkhttps://string-db.org/network/9606.ENSP00000355629Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family.
OTX1 protein networkhttps://string-db.org/network/9606.ENSP00000355631Homeobox protein OTX1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC- 3'.
GALNT2 protein networkhttps://string-db.org/network/9606.ENSP00000355632Polypeptide N-acetylgalactosaminyltransferase 2 soluble form; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a ser [...]
ABCB10 protein networkhttps://string-db.org/network/9606.ENSP00000355637ATP-binding cassette sub-family B member 10, mitochondrial; May mediate critical mitochondrial transport functions related to heme biosynthesis; Belongs to the ABC transporter superfamily. ABCB f [...]
ACTA1 protein networkhttps://string-db.org/network/9606.ENSP00000355645Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; B [...]
SPHAR protein networkhttps://string-db.org/network/9606.ENSP00000355649Protein SPHAR.
RAB4A protein networkhttps://string-db.org/network/9606.ENSP00000355651Ras-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling.
RHOU protein networkhttps://string-db.org/network/9606.ENSP00000355652Rho-related GTP-binding protein RhoU; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle [...]
H2AW protein networkhttps://string-db.org/network/9606.ENSP00000355656Histone H2A type 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones [...]
H3-4 protein networkhttps://string-db.org/network/9606.ENSP00000355657Histone H3.1t; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...]
TRIM17 protein networkhttps://string-db.org/network/9606.ENSP00000355658E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family.
IBA57 protein networkhttps://string-db.org/network/9606.ENSP00000355672Putative transferase CAF17, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway.
GJC2 protein networkhttps://string-db.org/network/9606.ENSP00000355675Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
GUK1 protein networkhttps://string-db.org/network/9606.ENSP00000355689Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors (By similari [...]
DLL1 protein networkhttps://string-db.org/network/9606.ENSP00000355718Delta-like protein 1; Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following [...]
PRSS38 protein networkhttps://string-db.org/network/9606.ENSP00000355719Serine protease 38.
JMJD4 protein networkhttps://string-db.org/network/9606.ENSP000003557202-oxoglutarate and iron-dependent oxygenase JMJD4; Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination effic [...]
CDC42BPA protein networkhttps://string-db.org/network/9606.ENSP00000355731Serine/threonine-protein kinase MRCK alpha; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization an [...]
ERMARD protein networkhttps://string-db.org/network/9606.ENSP00000355735Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development.
TCTE3 protein networkhttps://string-db.org/network/9606.ENSP00000355736Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein l [...]
COQ8A protein networkhttps://string-db.org/network/9606.ENSP00000355741Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respi [...]
PSEN2 protein networkhttps://string-db.org/network/9606.ENSP00000355747Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch [...]
THBS2 protein networkhttps://string-db.org/network/9606.ENSP00000355751Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
STUM protein networkhttps://string-db.org/network/9606.ENSP00000355752Protein stum homolog; Stum, mechanosensory transduction mediator homolog.
PARP1 protein networkhttps://string-db.org/network/9606.ENSP00000355759Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosy [...]
DACT2 protein networkhttps://string-db.org/network/9606.ENSP00000355760Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation [...]
AFDN protein networkhttps://string-db.org/network/9606.ENSP00000355771Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens [...]
ACBD3 protein networkhttps://string-db.org/network/9606.ENSP00000355777Golgi resident protein GCP60, N-terminally processed; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and [...]
H3-3A protein networkhttps://string-db.org/network/9606.ENSP00000355780H3.3 histone A.
LEFTY2 protein networkhttps://string-db.org/network/9606.ENSP00000355785Left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
TCP10L2 protein networkhttps://string-db.org/network/9606.ENSP00000355797T-complex protein 10A homolog 2; T-complex 10 like 2, pseudogene; Belongs to the TCP10 family.
GPR31 protein networkhttps://string-db.org/network/9606.ENSP0000035579912-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secr [...]
TMEM63A protein networkhttps://string-db.org/network/9606.ENSP00000355800CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion.
ENAH protein networkhttps://string-db.org/network/9606.ENSP00000355809Protein enabled homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellip [...]
FGFR1OP protein networkhttps://string-db.org/network/9606.ENSP00000355812FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes. Required for ciliation.
FBXO28 protein networkhttps://string-db.org/network/9606.ENSP00000355827F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
CAPN8 protein networkhttps://string-db.org/network/9606.ENSP00000355837Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells [...]
CCDC185 protein networkhttps://string-db.org/network/9606.ENSP00000355840Coiled-coil domain containing 185.
PDE10A protein networkhttps://string-db.org/network/9606.ENSP00000355847cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP a [...]
PRKN protein networkhttps://string-db.org/network/9606.ENSP00000355865E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SY [...]
DUSP10 protein networkhttps://string-db.org/network/9606.ENSP00000355866Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphor [...]
HLX protein networkhttps://string-db.org/network/9606.ENSP00000355870H2.0-like homeobox protein; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and h [...]
MARC1 protein networkhttps://string-db.org/network/9606.ENSP00000355877Mitochondrial amidoxime-reducing component 1; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycle [...]
MARC2 protein networkhttps://string-db.org/network/9606.ENSP00000355880Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycle [...]
IARS2 protein networkhttps://string-db.org/network/9606.ENSP00000355889Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial.
EPRS1 protein networkhttps://string-db.org/network/9606.ENSP00000355890Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catal [...]
SLC30A10 protein networkhttps://string-db.org/network/9606.ENSP00000355893Zinc transporter 10; Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of ne [...]
LYPLAL1 protein networkhttps://string-db.org/network/9606.ENSP00000355895Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates du [...]
TGFB2 protein networkhttps://string-db.org/network/9606.ENSP00000355896Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) ch [...]
RRP15 protein networkhttps://string-db.org/network/9606.ENSP00000355899RRP15-like protein; Ribosomal RNA processing 15 homolog.
SPATA17 protein networkhttps://string-db.org/network/9606.ENSP00000355900Spermatogenesis-associated protein 17; Spermatogenesis associated 17.
GPATCH2 protein networkhttps://string-db.org/network/9606.ENSP00000355902G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro.
ESRRG protein networkhttps://string-db.org/network/9606.ENSP00000355904Estrogen-related receptor gamma; Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter gen [...]
SLC22A2 protein networkhttps://string-db.org/network/9606.ENSP00000355920Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, fa [...]
CENPF protein networkhttps://string-db.org/network/9606.ENSP00000355922Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the pl [...]
PTPN14 protein networkhttps://string-db.org/network/9606.ENSP00000355923Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migrat [...]
SMYD2 protein networkhttps://string-db.org/network/9606.ENSP00000355924N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys [...]
PROX1 protein networkhttps://string-db.org/network/9606.ENSP00000355925Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number o [...]
RPS6KC1 protein networkhttps://string-db.org/network/9606.ENSP00000355927Ribosomal protein S6 kinase delta-1; May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes.
ANGEL2 protein networkhttps://string-db.org/network/9606.ENSP00000355929Angel homolog 2.
SLC22A1 protein networkhttps://string-db.org/network/9606.ENSP00000355930Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- methyl-4-phenylpyridinium (MPP), te [...]
FLVCR1 protein networkhttps://string-db.org/network/9606.ENSP00000355938Feline leukemia virus subgroup C receptor-related protein 1; [Isoform 1]: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both i [...]
NSL1 protein networkhttps://string-db.org/network/9606.ENSP00000355944Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
NENF protein networkhttps://string-db.org/network/9606.ENSP00000355955Neudesin; Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the em [...]
DTL protein networkhttps://string-db.org/network/9606.ENSP00000355958Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA sy [...]
INTS7 protein networkhttps://string-db.org/network/9606.ENSP00000355961Integrator complex subunit 7; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
LPGAT1 protein networkhttps://string-db.org/network/9606.ENSP00000355964Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear pref [...]
NEK2 protein networkhttps://string-db.org/network/9606.ENSP00000355966Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic [...]
SLC30A1 protein networkhttps://string-db.org/network/9606.ENSP00000355968Zinc transporter 1; May be involved in zinc transport out of the cell; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
RD3 protein networkhttps://string-db.org/network/9606.ENSP00000355969Protein RD3; Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2D an [...]
SERTAD4 protein networkhttps://string-db.org/network/9606.ENSP00000355979SERTA domain containing 4.
IRF6 protein networkhttps://string-db.org/network/9606.ENSP00000355988Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal developm [...]
TRAF3IP3 protein networkhttps://string-db.org/network/9606.ENSP00000355991TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation.
HSD11B1 protein networkhttps://string-db.org/network/9606.ENSP00000355995Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7 [...]
G0S2 protein networkhttps://string-db.org/network/9606.ENSP00000355996G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
PLXNA2 protein networkhttps://string-db.org/network/9606.ENSP00000356000Plexin-A2; Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growt [...]
MRPL18 protein networkhttps://string-db.org/network/9606.ENSP0000035600139S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperon [...]
ACAT2 protein networkhttps://string-db.org/network/9606.ENSP00000356015Acetyl-CoA acetyltransferase, cytosolic; Involved in the biosynthetic pathway of cholesterol.
CR1 protein networkhttps://string-db.org/network/9606.ENSP00000356016Complement receptor type 1; Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. [...]
CR2 protein networkhttps://string-db.org/network/9606.ENSP00000356024Complement receptor type 2; Receptor for complement C3, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. Participates in B lymphocytes activation.
CD55 protein networkhttps://string-db.org/network/9606.ENSP00000356030Complement decay-accelerating factor; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during [...]
TAGAP protein networkhttps://string-db.org/network/9606.ENSP00000356033T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation.
C4BPA protein networkhttps://string-db.org/network/9606.ENSP00000356037C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b [...]
PFKFB2 protein networkhttps://string-db.org/network/9606.ENSP000003560476-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate.
DYNLT1 protein networkhttps://string-db.org/network/9606.ENSP00000356056Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to a [...]
TMEM181 protein networkhttps://string-db.org/network/9606.ENSP00000356057Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
FCMR protein networkhttps://string-db.org/network/9606.ENSP00000356058Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitor [...]
TULP4 protein networkhttps://string-db.org/network/9606.ENSP00000356064Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent [...]
IL20 protein networkhttps://string-db.org/network/9606.ENSP00000356065Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through [...]
MAPKAPK2 protein networkhttps://string-db.org/network/9606.ENSP00000356070MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycl [...]
DYRK3 protein networkhttps://string-db.org/network/9606.ENSP00000356076Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress [...]
RHEX protein networkhttps://string-db.org/network/9606.ENSP00000356093Regulator of hemoglobinization and erythroid cell expansion protein; Acts as a signaling transduction factor of the EPO-EPOR signaling pathway promoting erythroid cell differentiation.
AVPR1B protein networkhttps://string-db.org/network/9606.ENSP00000356094Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system; Belon [...]
FAM72A protein networkhttps://string-db.org/network/9606.ENSP00000356096Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation. Belongs to the FAM72 family.
SLC26A9 protein networkhttps://string-db.org/network/9606.ENSP00000356102Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independe [...]
PM20D1 protein networkhttps://string-db.org/network/9606.ENSP00000356104N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endoge [...]
SLC41A1 protein networkhttps://string-db.org/network/9606.ENSP00000356105Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance.
RAB29 protein networkhttps://string-db.org/network/9606.ENSP00000356107Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity) [...]
NUCKS1 protein networkhttps://string-db.org/network/9606.ENSP00000356110Nuclear casein kinase and cyclin dependent kinase substrate 1.
SLC45A3 protein networkhttps://string-db.org/network/9606.ENSP00000356113Solute carrier family 45 member 3; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
MFSD4A protein networkhttps://string-db.org/network/9606.ENSP00000356115Major facilitator superfamily domain containing 4A.
LEMD1 protein networkhttps://string-db.org/network/9606.ENSP00000356121LEM domain containing 1.
KLHDC8A protein networkhttps://string-db.org/network/9606.ENSP00000356124Kelch domain containing 8A.
DSTYK protein networkhttps://string-db.org/network/9606.ENSP00000356130Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of bo [...]
CLDN20 protein networkhttps://string-db.org/network/9606.ENSP00000356133Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
TFB1M protein networkhttps://string-db.org/network/9606.ENSP00000356134Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also require [...]
TMEM81 protein networkhttps://string-db.org/network/9606.ENSP00000356135Transmembrane protein 81.
LRRN2 protein networkhttps://string-db.org/network/9606.ENSP00000356143Leucine rich repeat neuronal 2.
MDM4 protein networkhttps://string-db.org/network/9606.ENSP00000356150Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted de [...]
PIK3C2B protein networkhttps://string-db.org/network/9606.ENSP00000356155Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved [...]
PPP1R15B protein networkhttps://string-db.org/network/9606.ENSP00000356156Protein phosphatase 1 regulatory subunit 15B; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. Belongs to the PPP1R15 family.
KISS1 protein networkhttps://string-db.org/network/9606.ENSP00000356162Metastasis-suppressor KiSS-1; Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskelet [...]
ETNK2 protein networkhttps://string-db.org/network/9606.ENSP00000356169Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity).
SOX13 protein networkhttps://string-db.org/network/9606.ENSP00000356172Transcription factor SOX-13; Binds to the sequence 5'-AACAAT-3'.
OPTC protein networkhttps://string-db.org/network/9606.ENSP00000356191Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fi [...]
CHIT1 protein networkhttps://string-db.org/network/9606.ENSP00000356198Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
MTRF1L protein networkhttps://string-db.org/network/9606.ENSP00000356202Peptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA [...]
ADORA1 protein networkhttps://string-db.org/network/9606.ENSP00000356205Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.
TMEM183A protein networkhttps://string-db.org/network/9606.ENSP00000356211Transmembrane protein 183A.
VIP protein networkhttps://string-db.org/network/9606.ENSP00000356213Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, sto [...]
MYCT1 protein networkhttps://string-db.org/network/9606.ENSP00000356214Myc target protein 1; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpressio [...]
CYB5R1 protein networkhttps://string-db.org/network/9606.ENSP00000356218NADH-cytochrome b5 reductase 1; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemogl [...]
SYNE1 protein networkhttps://string-db.org/network/9606.ENSP00000356224Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC [...]
KLHL12 protein networkhttps://string-db.org/network/9606.ENSP00000356230Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(K [...]
RABIF protein networkhttps://string-db.org/network/9606.ENSP00000356231Guanine nucleotide exchange factor MSS4; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less act [...]
KDM5B protein networkhttps://string-db.org/network/9606.ENSP00000356233Lysine-specific demethylase 5B; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27' [...]
SYT2 protein networkhttps://string-db.org/network/9606.ENSP00000356237Synaptotagmin-2; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking [...]
LGR6 protein networkhttps://string-db.org/network/9606.ENSP00000356247Leucine-rich repeat-containing G-protein coupled receptor 6; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epi [...]
GPR37L1 protein networkhttps://string-db.org/network/9606.ENSP00000356251G-protein coupled receptor 37-like 1; G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK [...]
TIMM17A protein networkhttps://string-db.org/network/9606.ENSP00000356256Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across [...]
LMOD1 protein networkhttps://string-db.org/network/9606.ENSP00000356257Leiomodin-1; Mediates nucleation of actin filaments. Belongs to the tropomodulin family.
ARMT1 protein networkhttps://string-db.org/network/9606.ENSP00000356263Damage-control phosphatase ARMT1; Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). [...]
NAV1 protein networkhttps://string-db.org/network/9606.ENSP00000356265Neuron navigator 1; May be involved in neuronal migration.
CSRP1 protein networkhttps://string-db.org/network/9606.ENSP00000356275Cysteine and glycine-rich protein 1; Could play a role in neuronal development.
PHLDA3 protein networkhttps://string-db.org/network/9606.ENSP00000356280Pleckstrin homology-like domain family A member 3; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 transl [...]
TMEM9 protein networkhttps://string-db.org/network/9606.ENSP00000356301Transmembrane protein 9; May be involved in intracellular transport.
ULBP3 protein networkhttps://string-db.org/network/9606.ENSP00000356308UL16-binding protein 3; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family.
RAET1L protein networkhttps://string-db.org/network/9606.ENSP00000356310UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family.
KIF14 protein networkhttps://string-db.org/network/9606.ENSP00000356319Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in ma [...]
ULBP2 protein networkhttps://string-db.org/network/9606.ENSP00000356320UL16-binding protein 2; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
RAET1G protein networkhttps://string-db.org/network/9606.ENSP00000356329UL-16 binding protein 5; [Isoform 1]: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. [Isoform 2]: Stimulates natural killer cells to secrete IFNG. Belo [...]
NR5A2 protein networkhttps://string-db.org/network/9606.ENSP00000356331Nuclear receptor subfamily 5 group A member 2; Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis [...]
NEK7 protein networkhttps://string-db.org/network/9606.ENSP00000356355Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitoti [...]
LHX9 protein networkhttps://string-db.org/network/9606.ENSP00000356357LIM/homeobox protein Lhx9; Involved in gonadal development.
C1orf53 protein networkhttps://string-db.org/network/9606.ENSP00000356363Uncharacterized protein C1orf53; Chromosome 1 open reading frame 53.
CRB1 protein networkhttps://string-db.org/network/9606.ENSP00000356370Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family.
ZBTB41 protein networkhttps://string-db.org/network/9606.ENSP00000356375Zinc finger and BTB domain-containing protein 41; May be involved in transcriptional regulation.
ASPM protein networkhttps://string-db.org/network/9606.ENSP00000356379Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle pol [...]
KATNA1 protein networkhttps://string-db.org/network/9606.ENSP00000356381Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular mi [...]
F13B protein networkhttps://string-db.org/network/9606.ENSP00000356382Coagulation factor XIII B chain; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin [...]
CFHR2 protein networkhttps://string-db.org/network/9606.ENSP00000356385Complement factor H-related protein 2; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...]
CFHR4 protein networkhttps://string-db.org/network/9606.ENSP00000356386Complement factor H-related protein 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
GINM1 protein networkhttps://string-db.org/network/9606.ENSP00000356389Glycoprotein integral membrane 1.
CFHR3 protein networkhttps://string-db.org/network/9606.ENSP00000356395Complement factor H-related protein 3; Might be involved in complement regulation.
CFH protein networkhttps://string-db.org/network/9606.ENSP00000356399Complement factor H; Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where [...]
B3GALT2 protein networkhttps://string-db.org/network/9606.ENSP00000356404Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also [...]
CDC73 protein networkhttps://string-db.org/network/9606.ENSP00000356405Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 [...]
GLRX2 protein networkhttps://string-db.org/network/9606.ENSP00000356410Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved i [...]
RO60 protein networkhttps://string-db.org/network/9606.ENSP0000035641660 kDa SS-A/Ro ribonucleoprotein; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of thes [...]
UCHL5 protein networkhttps://string-db.org/network/9606.ENSP00000356421Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of th [...]
TAB2 protein networkhttps://string-db.org/network/9606.ENSP00000356426TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiqui [...]
RGS1 protein networkhttps://string-db.org/network/9606.ENSP00000356429Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene recept [...]
RGS18 protein networkhttps://string-db.org/network/9606.ENSP00000356430Regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G [...]
BRINP3 protein networkhttps://string-db.org/network/9606.ENSP00000356432BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, [...]
UST protein networkhttps://string-db.org/network/9606.ENSP00000356433Uronyl 2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weak [...]
PLA2G4A protein networkhttps://string-db.org/network/9606.ENSP00000356436Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the [...]
SASH1 protein networkhttps://string-db.org/network/9606.ENSP00000356437SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that include [...]
PTGS2 protein networkhttps://string-db.org/network/9606.ENSP00000356438Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, suc [...]
SAMD5 protein networkhttps://string-db.org/network/9606.ENSP00000356444Sterile alpha motif domain containing 5.
TPR protein networkhttps://string-db.org/network/9606.ENSP00000356448Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the [...]
RAB32 protein networkhttps://string-db.org/network/9606.ENSP00000356465Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchron [...]
IVNS1ABP protein networkhttps://string-db.org/network/9606.ENSP00000356468Influenza virus NS1A-binding protein; Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. P [...]
SWT1 protein networkhttps://string-db.org/network/9606.ENSP00000356470Transcriptional protein SWT1; SWT1 RNA endoribonuclease homolog.
TRMT1L protein networkhttps://string-db.org/network/9606.ENSP00000356476TRMT1-like protein; May play a role in motor coordination and exploratory behavior.
RNF2 protein networkhttps://string-db.org/network/9606.ENSP00000356480E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene re [...]
NIBAN1 protein networkhttps://string-db.org/network/9606.ENSP00000356481Protein Niban 1; Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress re [...]
EPM2A protein networkhttps://string-db.org/network/9606.ENSP00000356489Laforin; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitinati [...]
NCF2 protein networkhttps://string-db.org/network/9606.ENSP00000356505Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
UTRN protein networkhttps://string-db.org/network/9606.ENSP00000356515Utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane.
SHCBP1L protein networkhttps://string-db.org/network/9606.ENSP00000356518Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindl [...]
DHX9 protein networkhttps://string-db.org/network/9606.ENSP00000356520ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA re [...]
RGS16 protein networkhttps://string-db.org/network/9606.ENSP00000356529Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...]
RNASEL protein networkhttps://string-db.org/network/9606.ENSP000003565302-5A-dependent ribonuclease; Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects th [...]
TEDDM1 protein networkhttps://string-db.org/network/9606.ENSP00000356536Transmembrane epididymal protein 1.
STX11 protein networkhttps://string-db.org/network/9606.ENSP00000356540Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
SF3B5 protein networkhttps://string-db.org/network/9606.ENSP00000356541Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly [...]
CACNA1E protein networkhttps://string-db.org/network/9606.ENSP00000356545Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells. They are also involved in a variety of [...]
LTV1 protein networkhttps://string-db.org/network/9606.ENSP00000356548Protein LTV1 homolog; LTV1 ribosome biogenesis factor.
IER5 protein networkhttps://string-db.org/network/9606.ENSP00000356549Immediate early response gene 5 protein; Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- [...]
KIAA1614 protein networkhttps://string-db.org/network/9606.ENSP00000356560Uncharacterized protein KIAA1614; KIAA1614.
XPR1 protein networkhttps://string-db.org/network/9606.ENSP00000356562Xenotropic and polytropic retrovirus receptor 1; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyp [...]
PEX3 protein networkhttps://string-db.org/network/9606.ENSP00000356563Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is nece [...]
QSOX1 protein networkhttps://string-db.org/network/9606.ENSP00000356574Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond fo [...]
HIVEP2 protein networkhttps://string-db.org/network/9606.ENSP00000356576Transcription factor HIVEP2; This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, [...]
CEP350 protein networkhttps://string-db.org/network/9606.ENSP00000356579Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to th [...]
ADGRG6 protein networkhttps://string-db.org/network/9606.ENSP00000356581Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins a [...]
TOR1AIP2 protein networkhttps://string-db.org/network/9606.ENSP00000356584Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TO [...]
NPHS2 protein networkhttps://string-db.org/network/9606.ENSP00000356587Podocin; Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
AXDND1 protein networkhttps://string-db.org/network/9606.ENSP00000356590Axonemal dynein light chain domain containing 1.
SOAT1 protein networkhttps://string-db.org/network/9606.ENSP00000356591Sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary choles [...]
TOR3A protein networkhttps://string-db.org/network/9606.ENSP00000356599Torsin-3A; Torsin family 3 member A.
VTA1 protein networkhttps://string-db.org/network/9606.ENSP00000356602Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati [...]
RALGPS2 protein networkhttps://string-db.org/network/9606.ENSP00000356607Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the s [...]
RASAL2 protein networkhttps://string-db.org/network/9606.ENSP00000356621Ras GTPase-activating protein nGAP; Inhibitory regulator of the Ras-cyclic AMP pathway.
HECA protein networkhttps://string-db.org/network/9606.ENSP00000356630Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system a [...]
ABRACL protein networkhttps://string-db.org/network/9606.ENSP00000356632Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family.
PAPPA2 protein networkhttps://string-db.org/network/9606.ENSP00000356634Pappalysin-2; Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3. Belongs [...]
COP1 protein networkhttps://string-db.org/network/9606.ENSP00000356641E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an [...]
TNR protein networkhttps://string-db.org/network/9606.ENSP00000356646Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a s [...]
CACYBP protein networkhttps://string-db.org/network/9606.ENSP00000356652Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 com [...]
GPR52 protein networkhttps://string-db.org/network/9606.ENSP00000356658G-protein coupled receptor 52; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activit [...]
RC3H1 protein networkhttps://string-db.org/network/9606.ENSP00000356669Roquin-1; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, [...]
SERPINC1 protein networkhttps://string-db.org/network/9606.ENSP00000356671Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and X [...]
ZBTB37 protein networkhttps://string-db.org/network/9606.ENSP00000356674Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation.
SLC9C2 protein networkhttps://string-db.org/network/9606.ENSP00000356687Sodium/hydrogen exchanger 11; Involved in pH regulation.
FASLG protein networkhttps://string-db.org/network/9606.ENSP00000356694Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-medi [...]
SUCO protein networkhttps://string-db.org/network/9606.ENSP00000356696SUN domain-containing ossification factor; Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarit [...]
C1orf105 protein networkhttps://string-db.org/network/9606.ENSP00000356700Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105.
PIGC protein networkhttps://string-db.org/network/9606.ENSP00000356702Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosami [...]
OLIG3 protein networkhttps://string-db.org/network/9606.ENSP00000356708Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.
IFNGR1 protein networkhttps://string-db.org/network/9606.ENSP00000356713Interferon gamma receptor 1; Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Plays an e [...]
FMO4 protein networkhttps://string-db.org/network/9606.ENSP00000356723Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
FMO3 protein networkhttps://string-db.org/network/9606.ENSP00000356729Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well a [...]
MROH9 protein networkhttps://string-db.org/network/9606.ENSP00000356733Maestro heat like repeat family member 9.
GORAB protein networkhttps://string-db.org/network/9606.ENSP00000356737Golgin, RAB6 interacting.
SCYL3 protein networkhttps://string-db.org/network/9606.ENSP00000356746Protein-associating with the carboxyl-terminal domain of ezrin; May play a role in regulating cell adhesion/migration complexes in migrating cells.
F5 protein networkhttps://string-db.org/network/9606.ENSP00000356771Coagulation factor V heavy chain; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to t [...]
CCDC181 protein networkhttps://string-db.org/network/9606.ENSP00000356780Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids. Belongs to the CCDC181 family.
BLZF1 protein networkhttps://string-db.org/network/9606.ENSP00000356782Golgin-45; Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
NME7 protein networkhttps://string-db.org/network/9606.ENSP00000356785Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...]
ATP1B1 protein networkhttps://string-db.org/network/9606.ENSP00000356790Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...]
DPT protein networkhttps://string-db.org/network/9606.ENSP00000356791Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. E [...]
XCL1 protein networkhttps://string-db.org/network/9606.ENSP00000356792Lymphotactin; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell d [...]
XCL2 protein networkhttps://string-db.org/network/9606.ENSP00000356793Cytokine SCM-1 beta; Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
TBX19 protein networkhttps://string-db.org/network/9606.ENSP00000356795T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulati [...]
TIPRL protein networkhttps://string-db.org/network/9606.ENSP00000356807TIP41-like protein; May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL [...]
HBS1L protein networkhttps://string-db.org/network/9606.ENSP00000356811HBS1-like protein; HBS1 like translational GTPase; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.
DCAF6 protein networkhttps://string-db.org/network/9606.ENSP00000356814DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor [...]
ADCY10 protein networkhttps://string-db.org/network/9606.ENSP00000356825Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critic [...]
RCSD1 protein networkhttps://string-db.org/network/9606.ENSP00000356828CapZ-interacting protein; Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.
SGK1 protein networkhttps://string-db.org/network/9606.ENSP00000356832Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription [...]
POU2F1 protein networkhttps://string-db.org/network/9606.ENSP00000356840POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) an [...]
GPA33 protein networkhttps://string-db.org/network/9606.ENSP00000356842Cell surface A33 antigen; May play a role in cell-cell recognition and signaling.
MAEL protein networkhttps://string-db.org/network/9606.ENSP00000356846Protein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts v [...]
TADA1 protein networkhttps://string-db.org/network/9606.ENSP00000356848Transcriptional adapter 1; Probably involved in transcriptional regulation.
POGK protein networkhttps://string-db.org/network/9606.ENSP00000356849Pogo transposable element derived with KRAB domain.
UCK2 protein networkhttps://string-db.org/network/9606.ENSP00000356853Uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use [...]
TCF21 protein networkhttps://string-db.org/network/9606.ENSP00000356857Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in t [...]
MGST3 protein networkhttps://string-db.org/network/9606.ENSP00000356864Microsomal glutathione S-transferase 3; Catalyzes oxydation of hydroxy-fatty acids. Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro. May participate to the lipi [...]
CCDC190 protein networkhttps://string-db.org/network/9606.ENSP00000356886Coiled-coil domain containing 190.
DDR2 protein networkhttps://string-db.org/network/9606.ENSP00000356899Discoidin domain-containing receptor 2; Tyrosine kinase involved in the regulation of tissues remodeling. It functions as cell surface receptor for fibrillar collagen and regulates cell different [...]
VNN1 protein networkhttps://string-db.org/network/9606.ENSP00000356905Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the ca [...]
SH2D1B protein networkhttps://string-db.org/network/9606.ENSP00000356906SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling se [...]
TAAR2 protein networkhttps://string-db.org/network/9606.ENSP00000356908Trace amine-associated receptor 2; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
SPATA46 protein networkhttps://string-db.org/network/9606.ENSP00000356912Spermatogenesis-associated protein 46; Plays a role in spermiogenesis and fertilization.
OLFML2B protein networkhttps://string-db.org/network/9606.ENSP00000356917Olfactomedin-like protein 2B; Olfactomedin like 2B.
STX7 protein networkhttps://string-db.org/network/9606.ENSP00000356918Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking f [...]
ATF6 protein networkhttps://string-db.org/network/9606.ENSP00000356919Processed cyclic AMP-dependent transcription factor ATF-6 alpha; Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded pro [...]
DUSP12 protein networkhttps://string-db.org/network/9606.ENSP00000356920Dual specificity protein phosphatase 12; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in [...]
FCRLB protein networkhttps://string-db.org/network/9606.ENSP00000356925Fc receptor like B.
FCRLA protein networkhttps://string-db.org/network/9606.ENSP00000356936Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis.
MOXD1 protein networkhttps://string-db.org/network/9606.ENSP00000356940Monooxygenase DBH like 1.
FCGR3A protein networkhttps://string-db.org/network/9606.ENSP00000356946Low affinity immunoglobulin gamma Fc region receptor III-A; Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytot [...]
CFAP126 protein networkhttps://string-db.org/network/9606.ENSP00000356951Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. R [...]
SDHC protein networkhttps://string-db.org/network/9606.ENSP00000356953Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport [...]
CCN2 protein networkhttps://string-db.org/network/9606.ENSP00000356954CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cati [...]
NR1I3 protein networkhttps://string-db.org/network/9606.ENSP00000356959Nuclear receptor subfamily 1 group I member 3; Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase [...]
TOMM40L protein networkhttps://string-db.org/network/9606.ENSP00000356967Mitochondrial import receptor subunit TOM40B; Potential channel-forming protein implicated in import of protein precursors into mitochondria; Belongs to the Tom40 family.
APOA2 protein networkhttps://string-db.org/network/9606.ENSP00000356969Truncated apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family.
NDUFS2 protein networkhttps://string-db.org/network/9606.ENSP00000356972NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...]
ADAMTS4 protein networkhttps://string-db.org/network/9606.ENSP00000356975A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of [...]
PPOX protein networkhttps://string-db.org/network/9606.ENSP00000356978Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
USP21 protein networkhttps://string-db.org/network/9606.ENSP00000356981Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A r [...]
UFC1 protein networkhttps://string-db.org/network/9606.ENSP00000356982Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage; Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.
DEDD protein networkhttps://string-db.org/network/9606.ENSP00000356984Death effector domain-containing protein; A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating [...]
NIT1 protein networkhttps://string-db.org/network/9606.ENSP00000356988Deaminated glutathione amidase; Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmf [...]
PFDN2 protein networkhttps://string-db.org/network/9606.ENSP00000356989Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
KLHDC9 protein networkhttps://string-db.org/network/9606.ENSP00000356990Kelch domain containing 9.
NECTIN4 protein networkhttps://string-db.org/network/9606.ENSP00000356991Processed poliovirus receptor-related protein 4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions wit [...]
ARHGAP30 protein networkhttps://string-db.org/network/9606.ENSP00000356992Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42.
USF1 protein networkhttps://string-db.org/network/9606.ENSP00000357000Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.
F11R protein networkhttps://string-db.org/network/9606.ENSP00000357005Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-P [...]
ITLN2 protein networkhttps://string-db.org/network/9606.ENSP00000357008Intelectin-2; May play a role in the defense system against pathogens.
CD244 protein networkhttps://string-db.org/network/9606.ENSP00000357012Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-c [...]
SLAMF7 protein networkhttps://string-db.org/network/9606.ENSP00000357022SLAM family member 7; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...]
SLAMF6 protein networkhttps://string-db.org/network/9606.ENSP00000357036SLAM family member 6; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...]
VANGL2 protein networkhttps://string-db.org/network/9606.ENSP00000357040Vang-like protein 2; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar c [...]
MED23 protein networkhttps://string-db.org/network/9606.ENSP00000357047Mediator of RNA polymerase II transcription subunit 23; Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator [...]
COPA protein networkhttps://string-db.org/network/9606.ENSP00000357048Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynt [...]
PEX19 protein networkhttps://string-db.org/network/9606.ENSP00000357051Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stab [...]
DCAF8 protein networkhttps://string-db.org/network/9606.ENSP00000357052DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
PEA15 protein networkhttps://string-db.org/network/9606.ENSP00000357055Astrocytic phosphoprotein PEA-15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By [...]
CASQ1 protein networkhttps://string-db.org/network/9606.ENSP00000357057Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic r [...]
ATP1A4 protein networkhttps://string-db.org/network/9606.ENSP00000357060Sodium/potassium-transporting ATPase subunit alpha-4; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...]
IGSF8 protein networkhttps://string-db.org/network/9606.ENSP00000357065Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and [...]
KCNJ9 protein networkhttps://string-db.org/network/9606.ENSP00000357067G protein-activated inward rectifier potassium channel 3; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium [...]
PIGM protein networkhttps://string-db.org/network/9606.ENSP00000357069GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly; [...]
SLAMF9 protein networkhttps://string-db.org/network/9606.ENSP00000357072SLAM family member 9; May play a role in the immune response.
IGSF9 protein networkhttps://string-db.org/network/9606.ENSP00000357073Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation. Belongs to the immunoglobulin superfamily. Turtle family.
TAGLN2 protein networkhttps://string-db.org/network/9606.ENSP00000357076Transgelin-2; Transgelin 2.
CFAP45 protein networkhttps://string-db.org/network/9606.ENSP00000357079Cilia and flagella associated protein 45.
VSIG8 protein networkhttps://string-db.org/network/9606.ENSP00000357080V-set and immunoglobulin domain containing 8.
FCRL6 protein networkhttps://string-db.org/network/9606.ENSP00000357086Fc receptor-like protein 6; Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic [...]
DUSP23 protein networkhttps://string-db.org/network/9606.ENSP00000357087Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAP [...]
FCER1A protein networkhttps://string-db.org/network/9606.ENSP00000357097High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding o [...]
ACKR1 protein networkhttps://string-db.org/network/9606.ENSP00000357103Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...]
CADM3 protein networkhttps://string-db.org/network/9606.ENSP00000357106Cell adhesion molecule 3; Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activit [...]
EPB41L2 protein networkhttps://string-db.org/network/9606.ENSP00000357110Band 4.1-like protein 2; Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase.
AIM2 protein networkhttps://string-db.org/network/9606.ENSP00000357112Interferon-inducible protein AIM2; Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon bi [...]
IFI16 protein networkhttps://string-db.org/network/9606.ENSP00000357113Gamma-interferon-inducible protein 16; Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May fun [...]
L3MBTL3 protein networkhttps://string-db.org/network/9606.ENSP00000357118Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...]
PYHIN1 protein networkhttps://string-db.org/network/9606.ENSP00000357122Pyrin and HIN domain-containing protein 1; Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads t [...]
MNDA protein networkhttps://string-db.org/network/9606.ENSP00000357123Myeloid cell nuclear differentiation antigen; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interfero [...]
TMEM244 protein networkhttps://string-db.org/network/9606.ENSP00000357125Transmembrane protein 244.
OR6K6 protein networkhttps://string-db.org/network/9606.ENSP00000357126Olfactory receptor 6K6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6K3 protein networkhttps://string-db.org/network/9606.ENSP00000357127Olfactory receptor 6K3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ARHGAP18 protein networkhttps://string-db.org/network/9606.ENSP00000357131Rho GTPase-activating protein 18; Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an i [...]
OR10R2 protein networkhttps://string-db.org/network/9606.ENSP00000357134Olfactory receptor 10R2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CD1E protein networkhttps://string-db.org/network/9606.ENSP00000357149T-cell surface glycoprotein CD1e, membrane-associated; T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and [...]
CD1B protein networkhttps://string-db.org/network/9606.ENSP00000357150T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
CD1C protein networkhttps://string-db.org/network/9606.ENSP00000357152T-cell surface glycoprotein CD1c; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
CD5L protein networkhttps://string-db.org/network/9606.ENSP00000357156CD5 antigen-like; Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory respo [...]
FCRL1 protein networkhttps://string-db.org/network/9606.ENSP00000357158Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
FCRL3 protein networkhttps://string-db.org/network/9606.ENSP00000357169Fc receptor-like protein 3; Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of [...]
ETV3 protein networkhttps://string-db.org/network/9606.ENSP00000357175ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferati [...]
ARHGEF11 protein networkhttps://string-db.org/network/9606.ENSP00000357177Rho guanine nucleotide exchange factor 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchang [...]
INSRR protein networkhttps://string-db.org/network/9606.ENSP00000357178Insulin receptor-related protein alpha chain; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an int [...]
HDGF protein networkhttps://string-db.org/network/9606.ENSP00000357189Hepatoma-derived growth factor; [Isoform 1]: Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein. [Isoform 3]: Has mitogenic activity for fibrobla [...]
RRNAD1 protein networkhttps://string-db.org/network/9606.ENSP00000357199Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.
NES protein networkhttps://string-db.org/network/9606.ENSP00000357206Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribut [...]
NAXE protein networkhttps://string-db.org/network/9606.ENSP00000357218NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisi [...]
TTC24 protein networkhttps://string-db.org/network/9606.ENSP00000357219Tetratricopeptide repeat domain 24.
TSACC protein networkhttps://string-db.org/network/9606.ENSP00000357238TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family.
BGLAP protein networkhttps://string-db.org/network/9606.ENSP00000357255Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
PMF1 protein networkhttps://string-db.org/network/9606.ENSP00000357256Polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription pa [...]
SEMA4A protein networkhttps://string-db.org/network/9606.ENSP00000357265Semaphorin-4A; Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse devel [...]
LMNA protein networkhttps://string-db.org/network/9606.ENSP00000357283Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelop [...]
LAMTOR2 protein networkhttps://string-db.org/network/9606.ENSP00000357288Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...]
UBQLN4 protein networkhttps://string-db.org/network/9606.ENSP00000357292Ubiquilin-4; Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins. Acts by binding polyubiquitin chains of target proteins v [...]
RNF146 protein networkhttps://string-db.org/network/9606.ENSP00000357297E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. M [...]
RXFP4 protein networkhttps://string-db.org/network/9606.ENSP00000357301Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to t [...]
KHDC4 protein networkhttps://string-db.org/network/9606.ENSP00000357304KH homology domain-containing protein 4; RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved [...]
RIT1 protein networkhttps://string-db.org/network/9606.ENSP00000357305GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved i [...]
SYT11 protein networkhttps://string-db.org/network/9606.ENSP00000357307Synaptotagmin-11; Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin- mediated and bulk endocytosis, functions to ensure prec [...]
CENPW protein networkhttps://string-db.org/network/9606.ENSP00000357308Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
GON4L protein networkhttps://string-db.org/network/9606.ENSP00000357315GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.
DAP3 protein networkhttps://string-db.org/network/9606.ENSP0000035732028S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family.
YY1AP1 protein networkhttps://string-db.org/network/9606.ENSP00000357323YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activati [...]
RUSC1 protein networkhttps://string-db.org/network/9606.ENSP00000357336RUN and SH3 domain-containing protein 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed t [...]
HCN3 protein networkhttps://string-db.org/network/9606.ENSP00000357342Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3; Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions.
CLK2 protein networkhttps://string-db.org/network/9606.ENSP00000357345Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the sp [...]
HEY2 protein networkhttps://string-db.org/network/9606.ENSP00000357348Hairy/enhancer-of-split related with YRPW motif protein 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds prefe [...]
MTX1 protein networkhttps://string-db.org/network/9606.ENSP00000357360Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity).
THBS3 protein networkhttps://string-db.org/network/9606.ENSP00000357362Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.
DPM3 protein networkhttps://string-db.org/network/9606.ENSP00000357384Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER.
SLC50A1 protein networkhttps://string-db.org/network/9606.ENSP00000357389Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1.
EFNA1 protein networkhttps://string-db.org/network/9606.ENSP00000357392Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular [...]
EFNA3 protein networkhttps://string-db.org/network/9606.ENSP00000357393Ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...]
NKAIN2 protein networkhttps://string-db.org/network/9606.ENSP00000357402Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; Sodium/potassium transporting ATPase interacting 2.
DCST2 protein networkhttps://string-db.org/network/9606.ENSP00000357409DC-STAMP domain containing 2.
SMPDL3A protein networkhttps://string-db.org/network/9606.ENSP00000357425Acid sphingomyelinase-like phosphodiesterase 3a; Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has l [...]
HSF2 protein networkhttps://string-db.org/network/9606.ENSP00000357440Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unl [...]
PYGO2 protein networkhttps://string-db.org/network/9606.ENSP00000357442Pygopus homolog 2; Involved in signal transduction through the Wnt pathway.
PBXIP1 protein networkhttps://string-db.org/network/9606.ENSP00000357448Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks [...]
PMVK protein networkhttps://string-db.org/network/9606.ENSP00000357452Phosphomevalonate kinase.
MAN1A1 protein networkhttps://string-db.org/network/9606.ENSP00000357453Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce [...]
ADAR protein networkhttps://string-db.org/network/9606.ENSP00000357459Double-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect ge [...]
CHRNB2 protein networkhttps://string-db.org/network/9606.ENSP00000357461Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...]
TDRD10 protein networkhttps://string-db.org/network/9606.ENSP00000357465Tudor domain containing 10.
IL6R protein networkhttps://string-db.org/network/9606.ENSP00000357470Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL [...]
CEP85L protein networkhttps://string-db.org/network/9606.ENSP00000357474Centrosomal protein 85 like; Belongs to the CEP85 family.
NUS1 protein networkhttps://string-db.org/network/9606.ENSP00000357480Dehydrodolichyl diphosphate synthase complex subunit NUS1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) b [...]
GOPC protein networkhttps://string-db.org/network/9606.ENSP00000357484Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 curren [...]
ROS1 protein networkhttps://string-db.org/network/9606.ENSP00000357494Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. M [...]
C1orf43 protein networkhttps://string-db.org/network/9606.ENSP00000357507Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43.
C1orf189 protein networkhttps://string-db.org/network/9606.ENSP00000357511Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189.
ECHS1 protein networkhttps://string-db.org/network/9606.ENSP00000357535Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for croto [...]
FAM162B protein networkhttps://string-db.org/network/9606.ENSP00000357545Protein FAM162B; Family with sequence similarity 162 member B.
NUP210L protein networkhttps://string-db.org/network/9606.ENSP00000357547Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family.
KPNA5 protein networkhttps://string-db.org/network/9606.ENSP00000357552Importin subunit alpha-6; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...]
VENTX protein networkhttps://string-db.org/network/9606.ENSP00000357556Homeobox protein VENTX; May be involved in ventralization.
RAB13 protein networkhttps://string-db.org/network/9606.ENSP00000357564Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
ZUP1 protein networkhttps://string-db.org/network/9606.ENSP00000357565Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only we [...]
CFAP46 protein networkhttps://string-db.org/network/9606.ENSP00000357575Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement.
NKX6-2 protein networkhttps://string-db.org/network/9606.ENSP00000357581Homeobox protein Nkx-6.2; Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA se [...]
INPP5A protein networkhttps://string-db.org/network/9606.ENSP00000357583Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate [...]
CALHM5 protein networkhttps://string-db.org/network/9606.ENSP00000357588Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family.
TRAPPC3L protein networkhttps://string-db.org/network/9606.ENSP00000357591Trafficking protein particle complex subunit 3-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily [...]
CALHM6 protein networkhttps://string-db.org/network/9606.ENSP00000357594Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel.
TSPYL1 protein networkhttps://string-db.org/network/9606.ENSP00000357597Testis-specific Y-encoded-like protein 1; TSPY like 1.
LRRC27 protein networkhttps://string-db.org/network/9606.ENSP00000357603Leucine-rich repeat-containing protein 27; Leucine rich repeat containing 27.
SLC39A1 protein networkhttps://string-db.org/network/9606.ENSP00000357612Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologic [...]
CRTC2 protein networkhttps://string-db.org/network/9606.ENSP00000357622CREB-regulated transcription coactivator 2; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...]
BNIP3 protein networkhttps://string-db.org/network/9606.ENSP00000357625BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellu [...]
TCERG1L protein networkhttps://string-db.org/network/9606.ENSP00000357631Transcription elongation regulator 1 like.
GLRX3 protein networkhttps://string-db.org/network/9606.ENSP00000357633Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a crit [...]
EBF3 protein networkhttps://string-db.org/network/9606.ENSP00000357637Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5'- ATTCCCNNGGGAATT-3' (By similarity). Belongs to the COE family.
MKI67 protein networkhttps://string-db.org/network/9606.ENSP00000357643Proliferation marker protein Ki-67; Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitot [...]
GATAD2B protein networkhttps://string-db.org/network/9606.ENSP00000357644Transcriptional repressor p66-beta; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucle [...]
FAM229B protein networkhttps://string-db.org/network/9606.ENSP00000357645Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family.
TUBE1 protein networkhttps://string-db.org/network/9606.ENSP00000357651Tubulin epsilon 1; Belongs to the tubulin family.
CCN6 protein networkhttps://string-db.org/network/9606.ENSP00000357655Cellular communication network factor 6; Plays a role in mitochondrial electron transport and mitochondrial respiration. Through its regulation of the mitochondrial function may play a role in no [...]
CLRN3 protein networkhttps://string-db.org/network/9606.ENSP00000357660Clarin-3; Clarin 3; Belongs to the clarin family.
ADAM12 protein networkhttps://string-db.org/network/9606.ENSP00000357668Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells [...]
NPR1 protein networkhttps://string-db.org/network/9606.ENSP00000357669Atrial natriuretic peptide receptor 1; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in c [...]
SNAPIN protein networkhttps://string-db.org/network/9606.ENSP00000357674SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melano [...]
CHTOP protein networkhttps://string-db.org/network/9606.ENSP00000357679Chromatin target of PRMT1 protein; Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits t [...]
FANK1 protein networkhttps://string-db.org/network/9606.ENSP00000357682Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
S100A14 protein networkhttps://string-db.org/network/9606.ENSP00000357691Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apop [...]
S100A16 protein networkhttps://string-db.org/network/9606.ENSP00000357695Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their [...]
S100A3 protein networkhttps://string-db.org/network/9606.ENSP00000357702Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
S100A4 protein networkhttps://string-db.org/network/9606.ENSP00000357704S100 calcium binding protein A4.
S100A5 protein networkhttps://string-db.org/network/9606.ENSP00000357707Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites.
S100A6 protein networkhttps://string-db.org/network/9606.ENSP00000357709Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and in [...]
S100A7 protein networkhttps://string-db.org/network/9606.ENSP00000357711S100 calcium binding protein A7.
S100A7L2 protein networkhttps://string-db.org/network/9606.ENSP00000357714S100 calcium binding protein A7 like 2.
S100A7A protein networkhttps://string-db.org/network/9606.ENSP00000357718Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases.
S100A8 protein networkhttps://string-db.org/network/9606.ENSP00000357721Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis an [...]
S100A12 protein networkhttps://string-db.org/network/9606.ENSP00000357726Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activit [...]
S100A9 protein networkhttps://string-db.org/network/9606.ENSP00000357727Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, a [...]
LOR protein networkhttps://string-db.org/network/9606.ENSP00000357731Loricrin; Major keratinocyte cell envelope protein.
PRR9 protein networkhttps://string-db.org/network/9606.ENSP00000357733Proline-rich protein 9; Proline rich 9.
LELP1 protein networkhttps://string-db.org/network/9606.ENSP00000357736Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family.
SPRR2G protein networkhttps://string-db.org/network/9606.ENSP00000357737Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...]
SPRR2E protein networkhttps://string-db.org/network/9606.ENSP00000357740Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...]
SPRR2B protein networkhttps://string-db.org/network/9606.ENSP00000357744Small proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...]
SPRR2D protein networkhttps://string-db.org/network/9606.ENSP00000357746Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...]
BCCIP protein networkhttps://string-db.org/network/9606.ENSP00000357748BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spind [...]
SPRR1A protein networkhttps://string-db.org/network/9606.ENSP00000357751Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transg [...]
IVL protein networkhttps://string-db.org/network/9606.ENSP00000357753Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family.
SMCP protein networkhttps://string-db.org/network/9606.ENSP00000357754Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced s [...]
LCE1E protein networkhttps://string-db.org/network/9606.ENSP00000357759Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum.
C1orf68 protein networkhttps://string-db.org/network/9606.ENSP00000357764Skin-specific protein 32; Chromosome 1 open reading frame 68.
LCE4A protein networkhttps://string-db.org/network/9606.ENSP00000357766Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
LCE2A protein networkhttps://string-db.org/network/9606.ENSP00000357768Late cornified envelope protein 2A; Precursors of the cornified envelope of the stratum corneum.
LCE2B protein networkhttps://string-db.org/network/9606.ENSP00000357769Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum.
LCE2C protein networkhttps://string-db.org/network/9606.ENSP00000357772Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum.
LCE2D protein networkhttps://string-db.org/network/9606.ENSP00000357773Late cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum.
LCE3D protein networkhttps://string-db.org/network/9606.ENSP00000357776Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
LCE3E protein networkhttps://string-db.org/network/9606.ENSP00000357778Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.
CRCT1 protein networkhttps://string-db.org/network/9606.ENSP00000357779Cysteine rich C-terminal 1.
UROS protein networkhttps://string-db.org/network/9606.ENSP00000357787Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leadin [...]
FLG protein networkhttps://string-db.org/network/9606.ENSP00000357789Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
HRNR protein networkhttps://string-db.org/network/9606.ENSP00000357791Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family.
TCHHL1 protein networkhttps://string-db.org/network/9606.ENSP00000357796Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family.
MMP21 protein networkhttps://string-db.org/network/9606.ENSP00000357798Matrix metalloproteinase-21; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha [...]
S100A10 protein networkhttps://string-db.org/network/9606.ENSP00000357801Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of [...]
THEM4 protein networkhttps://string-db.org/network/9606.ENSP00000357804Acyl-coenzyme A thioesterase THEM4; Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid [...]
THEM5 protein networkhttps://string-db.org/network/9606.ENSP00000357807Acyl-coenzyme A thioesterase THEM5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-c [...]
LINGO4 protein networkhttps://string-db.org/network/9606.ENSP00000357810Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4; Leucine rich repeat and Ig domain containing 4.
TEX36 protein networkhttps://string-db.org/network/9606.ENSP00000357811Testis-expressed protein 36; Testis expressed 36.
TDRKH protein networkhttps://string-db.org/network/9606.ENSP00000357812Tudor and KH domain-containing protein; Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization [...]
MRPL9 protein networkhttps://string-db.org/network/9606.ENSP00000357823Mitochondrial ribosomal protein L9.
EEF1AKMT2 protein networkhttps://string-db.org/network/9606.ENSP00000357829EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase s [...]
LHPP protein networkhttps://string-db.org/network/9606.ENSP00000357835Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can [...]
OAT protein networkhttps://string-db.org/network/9606.ENSP00000357838Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.
TUFT1 protein networkhttps://string-db.org/network/9606.ENSP00000357842Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family.
SLC16A10 protein networkhttps://string-db.org/network/9606.ENSP00000357844Monocarboxylate transporter 10; Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epith [...]
BUB3 protein networkhttps://string-db.org/network/9606.ENSP00000357858Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes th [...]
GTF3C6 protein networkhttps://string-db.org/network/9606.ENSP00000357863General transcription factor 3C polypeptide 6; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...]
PI4KB protein networkhttps://string-db.org/network/9606.ENSP00000357869Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regula [...]
ACADSB protein networkhttps://string-db.org/network/9606.ENSP00000357873Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- [...]
PSMD4 protein networkhttps://string-db.org/network/9606.ENSP0000035787626S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
IKZF5 protein networkhttps://string-db.org/network/9606.ENSP00000357881Zinc finger protein Pegasus; DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor; Belongs to the Ikaros C2H2-type zinc-finger protein family.
PIP5K1A protein networkhttps://string-db.org/network/9606.ENSP00000357883Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) [...]
FAM24A protein networkhttps://string-db.org/network/9606.ENSP00000357889Protein FAM24A; Family with sequence similarity 24 member A.
FAM24B protein networkhttps://string-db.org/network/9606.ENSP00000357894Protein FAM24B; Family with sequence similarity 24 member B.
SCNM1 protein networkhttps://string-db.org/network/9606.ENSP00000357901Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.
LYSMD1 protein networkhttps://string-db.org/network/9606.ENSP00000357904LysM and putative peptidoglycan-binding domain-containing protein 1; LysM domain containing 1.
DMBT1 protein networkhttps://string-db.org/network/9606.ENSP00000357905Deleted in malignant brain tumors 1 protein; May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense [...]
TNFAIP8L2 protein networkhttps://string-db.org/network/9606.ENSP00000357906Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like recep [...]
CDK19 protein networkhttps://string-db.org/network/9606.ENSP00000357907Cyclin dependent kinase 19.
SEMA6C protein networkhttps://string-db.org/network/9606.ENSP00000357909Semaphorin-6C; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other ne [...]
GABPB2 protein networkhttps://string-db.org/network/9606.ENSP00000357914GA-binding protein subunit beta-2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats).
SLC22A16 protein networkhttps://string-db.org/network/9606.ENSP00000357915Solute carrier family 22 member 16; High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididyma [...]
MLLT11 protein networkhttps://string-db.org/network/9606.ENSP00000357917Protein AF1q; Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate.
DDO protein networkhttps://string-db.org/network/9606.ENSP00000357920D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate.
C1orf56 protein networkhttps://string-db.org/network/9606.ENSP00000357922Protein MENT; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.
BNIPL protein networkhttps://string-db.org/network/9606.ENSP00000357927Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein; May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.
CDC40 protein networkhttps://string-db.org/network/9606.ENSP00000357928Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome.
ANXA9 protein networkhttps://string-db.org/network/9606.ENSP00000357943Annexin A9; Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes. Belongs to the annexin family.
CEP57L1 protein networkhttps://string-db.org/network/9606.ENSP00000357966Centrosomal protein CEP57L1; Centrosomal protein which may be required for microtubule attachment to centrosomes; Belongs to the translokin family.
AFG1L protein networkhttps://string-db.org/network/9606.ENSP00000357973AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits [...]
NR2E1 protein networkhttps://string-db.org/network/9606.ENSP00000357979Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in [...]
HTRA1 protein networkhttps://string-db.org/network/9606.ENSP00000357980Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells [...]
CTSS protein networkhttps://string-db.org/network/9606.ENSP00000357981Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specifi [...]
PLEKHA1 protein networkhttps://string-db.org/network/9606.ENSP00000357986Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins t [...]
SEC63 protein networkhttps://string-db.org/network/9606.ENSP00000357998Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary r [...]
TACC2 protein networkhttps://string-db.org/network/9606.ENSP00000358001Transforming acidic coiled-coil-containing protein 2; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-medi [...]
SCML4 protein networkhttps://string-db.org/network/9606.ENSP00000358016Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...]
NSMCE4A protein networkhttps://string-db.org/network/9606.ENSP00000358019Non-structural maintenance of chromosomes element 4 homolog A; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may prom [...]
MCL1 protein networkhttps://string-db.org/network/9606.ENSP00000358022Induced myeloid leukemia cell differentiation protein Mcl-1; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates i [...]
PDSS2 protein networkhttps://string-db.org/network/9606.ENSP00000358033Decaprenyl-diphosphate synthase subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.
ADAMTSL4 protein networkhttps://string-db.org/network/9606.ENSP00000358035ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis.
QRSL1 protein networkhttps://string-db.org/network/9606.ENSP00000358042Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...]
ECM1 protein networkhttps://string-db.org/network/9606.ENSP00000358045Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. [...]
RTN4IP1 protein networkhttps://string-db.org/network/9606.ENSP00000358059Reticulon-4-interacting protein 1, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve [...]
TARS2 protein networkhttps://string-db.org/network/9606.ENSP00000358060Threonine--tRNA ligase, mitochondrial; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the [...]
CRYBG1 protein networkhttps://string-db.org/network/9606.ENSP00000358062Beta/gamma crystallin domain-containing protein 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton; Belongs to the beta/gamma [...]
RPRD2 protein networkhttps://string-db.org/network/9606.ENSP00000358064Regulation of nuclear pre-mRNA domain containing 2.
SEC23IP protein networkhttps://string-db.org/network/9606.ENSP00000358071SEC23-interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate [...]
ATG5 protein networkhttps://string-db.org/network/9606.ENSP00000358072Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E [...]
BAG3 protein networkhttps://string-db.org/network/9606.ENSP00000358081BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...]
TIAL1 protein networkhttps://string-db.org/network/9606.ENSP00000358089Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
PRDM1 protein networkhttps://string-db.org/network/9606.ENSP00000358092PR domain zinc finger protein 1; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident [...]
C1orf54 protein networkhttps://string-db.org/network/9606.ENSP00000358098Uncharacterized protein C1orf54; Chromosome 1 open reading frame 54.
RGS10 protein networkhttps://string-db.org/network/9606.ENSP00000358099Regulator of G-protein signaling 10; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transd [...]
APH1A protein networkhttps://string-db.org/network/9606.ENSP00000358105Gamma-secretase subunit APH-1A; Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch [...]
CA14 protein networkhttps://string-db.org/network/9606.ENSP00000358107Carbonic anhydrase 14; Reversible hydration of carbon dioxide.
PLEKHO1 protein networkhttps://string-db.org/network/9606.ENSP00000358120Pleckstrin homology domain-containing family O member 1; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target [...]
EIF3A protein networkhttps://string-db.org/network/9606.ENSP00000358140Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...]
SV2A protein networkhttps://string-db.org/network/9606.ENSP00000358142Synaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates ves [...]
CACUL1 protein networkhttps://string-db.org/network/9606.ENSP00000358147CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition.
BOLA1 protein networkhttps://string-db.org/network/9606.ENSP00000358149BolA-like protein 1; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably [...]
H2BC21 protein networkhttps://string-db.org/network/9606.ENSP00000358151Histone H2B type 2-E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
H3C14 protein networkhttps://string-db.org/network/9606.ENSP00000358154H3 clustered histone 14.
H2AC18 protein networkhttps://string-db.org/network/9606.ENSP00000358155Histone H2A type 2-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
ASCC3 protein networkhttps://string-db.org/network/9606.ENSP00000358159Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enablin [...]
H3C10 protein networkhttps://string-db.org/network/9606.ENSP00000358160H3 clustered histone 10.
FCGR1A protein networkhttps://string-db.org/network/9606.ENSP00000358165High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
FAM204A protein networkhttps://string-db.org/network/9606.ENSP00000358183Protein FAM204A; Family with sequence similarity 204 member A.
RAB11FIP2 protein networkhttps://string-db.org/network/9606.ENSP00000358200Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the tran [...]
VAX1 protein networkhttps://string-db.org/network/9606.ENSP00000358207Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrai [...]
SIM1 protein networkhttps://string-db.org/network/9606.ENSP00000358210Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
PRDM13 protein networkhttps://string-db.org/network/9606.ENSP00000358217PR domain zinc finger protein 13; May be involved in transcriptional regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily.
PNLIP protein networkhttps://string-db.org/network/9606.ENSP00000358223Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family.
PNLIPRP3 protein networkhttps://string-db.org/network/9606.ENSP00000358232Pancreatic lipase related protein 3.
GPR89B protein networkhttps://string-db.org/network/9606.ENSP00000358233G protein-coupled receptor 89B.
GJA8 protein networkhttps://string-db.org/network/9606.ENSP00000358238Gap junction alpha-8 protein; Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking [...]
FBXL4 protein networkhttps://string-db.org/network/9606.ENSP00000358247F-box and leucine rich repeat protein 4.
FAM160B1 protein networkhttps://string-db.org/network/9606.ENSP00000358251Protein FAM160B1; Family with sequence similarity 160 member B1.
CHD1L protein networkhttps://string-db.org/network/9606.ENSP00000358262Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-r [...]
KLHL32 protein networkhttps://string-db.org/network/9606.ENSP00000358265Kelch-like protein 32; Kelch like family member 32.
NDUFAF4 protein networkhttps://string-db.org/network/9606.ENSP00000358272NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell prolife [...]
UFL1 protein networkhttps://string-db.org/network/9606.ENSP00000358283E3 UFM1-protein ligase 1; E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysin [...]
CD160 protein networkhttps://string-db.org/network/9606.ENSP00000358294CD160 antigen, soluble form; [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anch [...]
ADRB1 protein networkhttps://string-db.org/network/9606.ENSP00000358301Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norep [...]
NHLRC2 protein networkhttps://string-db.org/network/9606.ENSP00000358307NHL repeat-containing protein 2; Required for normal embryonic development.
EPHA7 protein networkhttps://string-db.org/network/9606.ENSP00000358309Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
ITGA10 protein networkhttps://string-db.org/network/9606.ENSP00000358310Integrin alpha-10; Integrin alpha-10/beta-1 is a receptor for collagen; Belongs to the integrin alpha chain family.
PEX11B protein networkhttps://string-db.org/network/9606.ENSP00000358312Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes memb [...]
PLEKHS1 protein networkhttps://string-db.org/network/9606.ENSP00000358316Pleckstrin homology domain containing S1.
POLR3GL protein networkhttps://string-db.org/network/9606.ENSP00000358320DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific per [...]
CASP7 protein networkhttps://string-db.org/network/9606.ENSP00000358327Caspase-7 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytical [...]
MAP3K7 protein networkhttps://string-db.org/network/9606.ENSP00000358335Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...]
GJA10 protein networkhttps://string-db.org/network/9606.ENSP00000358358Gap junction alpha-10 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to [...]
PDE4DIP protein networkhttps://string-db.org/network/9606.ENSP00000358363Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes (By similarity).
NRAP protein networkhttps://string-db.org/network/9606.ENSP00000358365Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular [...]
SCAF11 protein networkhttps://string-db.org/network/9606.ENSP00000358374Protein SCAF11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly.
FCGR1B protein networkhttps://string-db.org/network/9606.ENSP00000358391High affinity immunoglobulin gamma Fc receptor IB; May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response.
FAM72B protein networkhttps://string-db.org/network/9606.ENSP00000358397Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family.
MDN1 protein networkhttps://string-db.org/network/9606.ENSP00000358400Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition poi [...]
ADAM30 protein networkhttps://string-db.org/network/9606.ENSP00000358407Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP [...]
ZDHHC6 protein networkhttps://string-db.org/network/9606.ENSP00000358413Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is r [...]
HMGCS2 protein networkhttps://string-db.org/network/9606.ENSP00000358414Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
HSD3B1 protein networkhttps://string-db.org/network/9606.ENSP000003584213 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delt [...]
RRAGD protein networkhttps://string-db.org/network/9606.ENSP00000358423Ras-related GTP-binding protein D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its sub [...]
TBX15 protein networkhttps://string-db.org/network/9606.ENSP00000358437T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchy [...]
GDAP2 protein networkhttps://string-db.org/network/9606.ENSP00000358451Ganglioside induced differentiation associated protein 2.
TENT5C protein networkhttps://string-db.org/network/9606.ENSP00000358458Terminal nucleotidyltransferase 5C; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase which enhances mRNA stability and gene expression. Mainly targets mRNAs encoding endo [...]
CLIC2 protein networkhttps://string-db.org/network/9606.ENSP00000358460Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occu [...]
SHOC2 protein networkhttps://string-db.org/network/9606.ENSP00000358464Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, [...]
RAB39B protein networkhttps://string-db.org/network/9606.ENSP00000358466Ras-related protein Rab-39B; Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to t [...]
VTCN1 protein networkhttps://string-db.org/network/9606.ENSP00000358470V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of [...]
BRCC3 protein networkhttps://string-db.org/network/9606.ENSP00000358474Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Compone [...]
TTF2 protein networkhttps://string-db.org/network/9606.ENSP00000358478Transcription termination factor 2; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May [...]
CD101 protein networkhttps://string-db.org/network/9606.ENSP00000358482Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine k [...]
MTCP1 protein networkhttps://string-db.org/network/9606.ENSP00000358488Protein p13 MTCP-1; Enhances the phosphorylation and activation of AKT1 and AKT2. Belongs to the TCL1 family.
CD2 protein networkhttps://string-db.org/network/9606.ENSP00000358490T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the [...]
IGSF3 protein networkhttps://string-db.org/network/9606.ENSP00000358495Immunoglobulin superfamily member 3.
CMC4 protein networkhttps://string-db.org/network/9606.ENSP00000358496Cx9C motif-containing protein 4; C-X9-C motif containing 4; Belongs to the CMC4 family.
RNGTT protein networkhttps://string-db.org/network/9606.ENSP00000358497Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. [...]
CD58 protein networkhttps://string-db.org/network/9606.ENSP00000358501Lymphocyte function-associated antigen 3; Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-inde [...]
FUNDC2 protein networkhttps://string-db.org/network/9606.ENSP00000358510FUN14 domain containing 2; Belongs to the FUN14 family.
MAB21L3 protein networkhttps://string-db.org/network/9606.ENSP00000358512Protein mab-21-like 3; Mab-21 like 3.
CNR1 protein networkhttps://string-db.org/network/9606.ENSP00000358513Cannabinoid receptor 1; G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as w [...]
SLC22A15 protein networkhttps://string-db.org/network/9606.ENSP00000358515Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.
F8A2 protein networkhttps://string-db.org/network/9606.ENSP0000035851840-kDa huntingtin-associated protein; RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT- [...]
NHLH2 protein networkhttps://string-db.org/network/9606.ENSP00000358519Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
NGF protein networkhttps://string-db.org/network/9606.ENSP00000358525Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptor [...]
TSPAN2 protein networkhttps://string-db.org/network/9606.ENSP00000358529Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature she [...]
RBM20 protein networkhttps://string-db.org/network/9606.ENSP00000358532RNA-binding protein 20; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).
SYCP1 protein networkhttps://string-db.org/network/9606.ENSP00000358535Synaptonemal complex protein 1; Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly [...]
SIKE1 protein networkhttps://string-db.org/network/9606.ENSP00000358541Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulate [...]
SMIM9 protein networkhttps://string-db.org/network/9606.ENSP00000358542Small integral membrane protein 9.
MPP1 protein networkhttps://string-db.org/network/9606.ENSP0000035854755 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PI [...]
NRAS protein networkhttps://string-db.org/network/9606.ENSP00000358548GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
RARS2 protein networkhttps://string-db.org/network/9606.ENSP00000358549Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial.
BCAS2 protein networkhttps://string-db.org/network/9606.ENSP00000358554Pre-mRNA-splicing factor SPF27; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and i [...]
DKC1 protein networkhttps://string-db.org/network/9606.ENSP00000358563H/ACA ribonucleoprotein complex subunit DKC1; [Isoform 1]: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This inv [...]
SLC35A1 protein networkhttps://string-db.org/network/9606.ENSP00000358565CMP-sialic acid transporter; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free [...]
CFAP206 protein networkhttps://string-db.org/network/9606.ENSP00000358575Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes.
AP4B1 protein networkhttps://string-db.org/network/9606.ENSP00000358582AP-4 complex subunit beta-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They [...]
ZNF292 protein networkhttps://string-db.org/network/9606.ENSP00000358590Zinc finger protein 292; May be involved in transcriptional regulation.
DUSP5 protein networkhttps://string-db.org/network/9606.ENSP00000358596Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK [...]
SMNDC1 protein networkhttps://string-db.org/network/9606.ENSP00000358616Survival of motor neuron-related-splicing factor 30; Necessary for spliceosome assembly. Overexpression causes apoptosis; Belongs to the SMN family.
PHTF1 protein networkhttps://string-db.org/network/9606.ENSP00000358617Putative homeodomain transcription factor 1; May play a role in transcription regulation.
SYNCRIP protein networkhttps://string-db.org/network/9606.ENSP00000358635Heterogeneous nuclear ribonucleoprotein Q; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA st [...]
TAFA3 protein networkhttps://string-db.org/network/9606.ENSP00000358644Chemokine-like protein TAFA-3; Plays a role in the regulation of microglia polarization. Belongs to the TAFA family.
UBL4A protein networkhttps://string-db.org/network/9606.ENSP00000358674Ubiquitin-like protein 4A; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and p [...]
TBX18 protein networkhttps://string-db.org/network/9606.ENSP00000358677T-box transcription factor TBX18; Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter an [...]
CYB5R4 protein networkhttps://string-db.org/network/9606.ENSP00000358695Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress [...]
PLXNA3 protein networkhttps://string-db.org/network/9606.ENSP00000358696Plexin-A3; Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous [...]
WNT2B protein networkhttps://string-db.org/network/9606.ENSP00000358698Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung [...]
RIPPLY2 protein networkhttps://string-db.org/network/9606.ENSP00000358703Protein ripply2; Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).
PRSS35 protein networkhttps://string-db.org/network/9606.ENSP00000358714Serine protease 35; Belongs to the peptidase S1 family.
SORCS3 protein networkhttps://string-db.org/network/9606.ENSP00000358715Sortilin related VPS10 domain containing receptor 3; Belongs to the VPS10-related sortilin family. SORCS subfamily.
DDX20 protein networkhttps://string-db.org/network/9606.ENSP00000358716Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, pla [...]
CFAP58 protein networkhttps://string-db.org/network/9606.ENSP00000358718Cilia and flagella associated protein 58; Belongs to the CFAP58 family.
ME1 protein networkhttps://string-db.org/network/9606.ENSP00000358719Malic enzyme 1.
RAP1A protein networkhttps://string-db.org/network/9606.ENSP00000358723Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with R [...]
GSTO1 protein networkhttps://string-db.org/network/9606.ENSP00000358727Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione [...]
TMIGD3 protein networkhttps://string-db.org/network/9606.ENSP00000358730Transmembrane domain-containing protein TMIGD3; [Isoform 1]: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity.
ATP5PB protein networkhttps://string-db.org/network/9606.ENSP00000358737ATP synthase F(0) complex subunit B1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...]
RWDD2A protein networkhttps://string-db.org/network/9606.ENSP00000358739RWD domain containing 2A.
SFR1 protein networkhttps://string-db.org/network/9606.ENSP00000358742Swi5-dependent recombination DNA repair protein 1 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcript [...]
OVGP1 protein networkhttps://string-db.org/network/9606.ENSP00000358747Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
PIFO protein networkhttps://string-db.org/network/9606.ENSP00000358753Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/c [...]
CHIA protein networkhttps://string-db.org/network/9606.ENSP00000358755Acidic mammalian chitinase; Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune respons [...]
UBE3D protein networkhttps://string-db.org/network/9606.ENSP00000358762E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degr [...]
TPBG protein networkhttps://string-db.org/network/9606.ENSP00000358765Trophoblast glycoprotein; May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
SLK protein networkhttps://string-db.org/network/9606.ENSP00000358770STE20-like serine/threonine-protein kinase; Mediates apoptosis and actin stress fiber dissolution.
ATP6AP1 protein networkhttps://string-db.org/network/9606.ENSP00000358777V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-ty [...]
LRIF1 protein networkhttps://string-db.org/network/9606.ENSP00000358778Ligand-dependent nuclear receptor-interacting factor 1; Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress [...]
NPBWR2 protein networkhttps://string-db.org/network/9606.ENSP00000358783Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food inta [...]
KCNA3 protein networkhttps://string-db.org/network/9606.ENSP00000358784Potassium voltage-gated channel subfamily A member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...]
KCNA10 protein networkhttps://string-db.org/network/9606.ENSP00000358786Potassium voltage-gated channel subfamily A member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the vol [...]
SLC16A4 protein networkhttps://string-db.org/network/9606.ENSP00000358794Monocarboxylate transporter 5; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...]
NEURL1 protein networkhttps://string-db.org/network/9606.ENSP00000358795E3 ubiquitin-protein ligase NEURL1; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulat [...]
CALHM3 protein networkhttps://string-db.org/network/9606.ENSP00000358798Calcium homeostasis modulator protein 3; Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP. Together with CALHM1, forms a fast-activating volta [...]
RBM15 protein networkhttps://string-db.org/network/9606.ENSP00000358799RNA-binding protein 15; RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeo [...]
KCNC4 protein networkhttps://string-db.org/network/9606.ENSP00000358802Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in res [...]
STRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000358810Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.
PDCD11 protein networkhttps://string-db.org/network/9606.ENSP00000358812Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA.
TTK protein networkhttps://string-db.org/network/9606.ENSP00000358813Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB [...]
AHCYL1 protein networkhttps://string-db.org/network/9606.ENSP00000358814S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secret [...]
NEURL1B protein networkhttps://string-db.org/network/9606.ENSP00000358815E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands.
EPS8L3 protein networkhttps://string-db.org/network/9606.ENSP00000358820Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3.
DNASE1L1 protein networkhttps://string-db.org/network/9606.ENSP00000358824Deoxyribonuclease 1 like 1; Belongs to the DNase I family.
ELOVL4 protein networkhttps://string-db.org/network/9606.ENSP00000358831Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
ATP5MD protein networkhttps://string-db.org/network/9606.ENSP00000358840ATP synthase membrane subunit DAPIT, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...]
GSTM4 protein networkhttps://string-db.org/network/9606.ENSP00000358851Glutathione S-transferase Mu 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro- 2,4-dinitrobenzene.
SH3BGRL2 protein networkhttps://string-db.org/network/9606.ENSP00000358853SH3 domain binding glutamate rich protein like 2; Belongs to the SH3BGR family.
TAF5 protein networkhttps://string-db.org/network/9606.ENSP00000358854Transcription initiation factor TFIID subunit 5; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs compon [...]
EMD protein networkhttps://string-db.org/network/9606.ENSP00000358857Emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibi [...]
PCGF6 protein networkhttps://string-db.org/network/9606.ENSP00000358862Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprote [...]
INA protein networkhttps://string-db.org/network/9606.ENSP00000358865Alpha-internexin; Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the [...]
FLNA protein networkhttps://string-db.org/network/9606.ENSP00000358866Filamin-A; Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a s [...]
GNAI3 protein networkhttps://string-db.org/network/9606.ENSP00000358867Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in [...]
AMIGO1 protein networkhttps://string-db.org/network/9606.ENSP00000358880Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. [...]
CYB561D1 protein networkhttps://string-db.org/network/9606.ENSP00000358884Cytochrome b561 family member D1.
ATXN7L2 protein networkhttps://string-db.org/network/9606.ENSP00000358886Ataxin-7-like protein 2; Ataxin 7 like 2.
SYPL2 protein networkhttps://string-db.org/network/9606.ENSP00000358888Synaptophysin-like protein 2; Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes.
CNNM2 protein networkhttps://string-db.org/network/9606.ENSP00000358894Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity [...]
AS3MT protein networkhttps://string-db.org/network/9606.ENSP00000358896Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylars [...]
SAMD10 protein networkhttps://string-db.org/network/9606.ENSP00000358902Sterile alpha motif domain containing 10.
CYP17A1 protein networkhttps://string-db.org/network/9606.ENSP00000358903Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for bo [...]
ZNF512B protein networkhttps://string-db.org/network/9606.ENSP00000358904Zinc finger protein 512B; May be involved in transcriptional regulation.
SFXN2 protein networkhttps://string-db.org/network/9606.ENSP00000358909Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria.
SUFU protein networkhttps://string-db.org/network/9606.ENSP00000358918Suppressor of fused homolog; Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down-regulates GLI2-mediated transactiv [...]
ACTR1A protein networkhttps://string-db.org/network/9606.ENSP00000358921Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
PSRC1 protein networkhttps://string-db.org/network/9606.ENSP00000358925Proline/serine-rich coiled-coil protein 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal [...]
TKTL1 protein networkhttps://string-db.org/network/9606.ENSP00000358931Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; B [...]
ABHD16B protein networkhttps://string-db.org/network/9606.ENSP00000358932Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family.
SARS1 protein networkhttps://string-db.org/network/9606.ENSP00000358939Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end [...]
OPN1MW2 protein networkhttps://string-db.org/network/9606.ENSP00000358945Medium-wave-sensitive opsin 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-prot [...]
CUEDC2 protein networkhttps://string-db.org/network/9606.ENSP00000358953CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estrad [...]
KIAA1324 protein networkhttps://string-db.org/network/9606.ENSP00000358955UPF0577 protein KIAA1324; May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway.
IRAK1BP1 protein networkhttps://string-db.org/network/9606.ENSP00000358956Interleukin-1 receptor-associated kinase 1-binding protein 1; Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Ac [...]
HTR1B protein networkhttps://string-db.org/network/9606.ENSP000003589635-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant [...]
C1orf194 protein networkhttps://string-db.org/network/9606.ENSP00000358965Protein C1orf194; May play an important role for the maintenance of myelin-axon integrity (By similarity). May affect intracellular Ca(2+) homeostasis.
IMPG1 protein networkhttps://string-db.org/network/9606.ENSP00000358966Interphotoreceptor matrix proteoglycan 1; May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix.
OPN1LW protein networkhttps://string-db.org/network/9606.ENSP00000358967Long-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
NFKB2 protein networkhttps://string-db.org/network/9606.ENSP00000358983Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are in [...]
MYO6 protein networkhttps://string-db.org/network/9606.ENSP00000358994Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reve [...]
IRAK1 protein networkhttps://string-db.org/network/9606.ENSP00000358997Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like recept [...]
TMEM187 protein networkhttps://string-db.org/network/9606.ENSP00000358999Transmembrane protein 187.
GBF1 protein networkhttps://string-db.org/network/9606.ENSP00000359000Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the [...]
TNFRSF6B protein networkhttps://string-db.org/network/9606.ENSP00000359013Tumor necrosis factor receptor superfamily member 6B; Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
AKNAD1 protein networkhttps://string-db.org/network/9606.ENSP00000359018Protein AKNAD1; AKNA domain containing 1.
PITX3 protein networkhttps://string-db.org/network/9606.ENSP00000359019Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its [...]
ELOVL3 protein networkhttps://string-db.org/network/9606.ENSP00000359022Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
STXBP3 protein networkhttps://string-db.org/network/9606.ENSP00000359025Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell su [...]
FNDC7 protein networkhttps://string-db.org/network/9606.ENSP00000359034Fibronectin type III domain containing 7.
PRPF38B protein networkhttps://string-db.org/network/9606.ENSP00000359042Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing.
ARHGAP4 protein networkhttps://string-db.org/network/9606.ENSP00000359045Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down- regulate Rho-like GTPase in hematopoietic cells.
HENMT1 protein networkhttps://string-db.org/network/9606.ENSP00000359049Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism [...]
ARMH3 protein networkhttps://string-db.org/network/9606.ENSP00000359050Armadillo-like helical domain-containing protein 3; Involved in GBF1 recruitment, Golgi maintenance and protein secretion.
FAM102B protein networkhttps://string-db.org/network/9606.ENSP00000359052Protein FAM102B; Family with sequence similarity 102 member B.
STMN3 protein networkhttps://string-db.org/network/9606.ENSP00000359070Stathmin-3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3; Belongs to the stathmin family.
VAV3 protein networkhttps://string-db.org/network/9606.ENSP00000359073Guanine nucleotide exchange factor VAV3; Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays [...]
L1CAM protein networkhttps://string-db.org/network/9606.ENSP00000359077Neural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain [...]
NTNG1 protein networkhttps://string-db.org/network/9606.ENSP00000359085Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
PRMT6 protein networkhttps://string-db.org/network/9606.ENSP00000359095Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong [...]
AMY1C protein networkhttps://string-db.org/network/9606.ENSP00000359096Amylase alpha 1C.
COX7A2 protein networkhttps://string-db.org/network/9606.ENSP00000359098Cytochrome c oxidase subunit 7A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The r [...]
AMY1A protein networkhttps://string-db.org/network/9606.ENSP00000359100Amylase alpha 1A.
COL11A1 protein networkhttps://string-db.org/network/9606.ENSP00000359114Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
SRPK3 protein networkhttps://string-db.org/network/9606.ENSP00000359119SRSF protein kinase 3; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, know [...]
DPH5 protein networkhttps://string-db.org/network/9606.ENSP00000359127Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 ( [...]
NPM3 protein networkhttps://string-db.org/network/9606.ENSP00000359128Nucleoplasmin-3; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function an [...]
EXTL2 protein networkhttps://string-db.org/network/9606.ENSP00000359131Processed exostosin-like 2; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha- [...]
DBT protein networkhttps://string-db.org/network/9606.ENSP000003591512-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and [...]
TRMT13 protein networkhttps://string-db.org/network/9606.ENSP00000359160tRNA:m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
DPCD protein networkhttps://string-db.org/network/9606.ENSP00000359170Protein DPCD; May play a role in the formation or function of ciliated cells.
MFSD14A protein networkhttps://string-db.org/network/9606.ENSP00000359171Hippocampus abundant transcript 1 protein; Major facilitator superfamily domain containing 14A.
SLC35A3 protein networkhttps://string-db.org/network/9606.ENSP00000359172UDP-N-acetylglucosamine transporter; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransfe [...]
POLL protein networkhttps://string-db.org/network/9606.ENSP00000359181DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) site [...]
PPDPF protein networkhttps://string-db.org/network/9606.ENSP00000359198Pancreatic progenitor cell differentiation and proliferation factor; Probable regulator of exocrine pancreas development. Belongs to the PPDPF family.
PLPPR4 protein networkhttps://string-db.org/network/9606.ENSP00000359204Phospholipid phosphatase-related protein type 4; Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts a [...]
BTRC protein networkhttps://string-db.org/network/9606.ENSP00000359206F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent prot [...]
DPYD protein networkhttps://string-db.org/network/9606.ENSP00000359211Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-flu [...]
LBX1 protein networkhttps://string-db.org/network/9606.ENSP00000359212Transcription factor LBX1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial musc [...]
TLX1 protein networkhttps://string-db.org/network/9606.ENSP00000359215T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.
PTBP2 protein networkhttps://string-db.org/network/9606.ENSP00000359216Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific m [...]
KAZALD1 protein networkhttps://string-db.org/network/9606.ENSP00000359219Kazal-type serine protease inhibitor domain-containing protein 1; Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity [...]
RWDD3 protein networkhttps://string-db.org/network/9606.ENSP00000359221RWD domain-containing protein 3; Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester [...]
TLCD4 protein networkhttps://string-db.org/network/9606.ENSP00000359222TLC domain containing 4.
ALG14 protein networkhttps://string-db.org/network/9606.ENSP00000359224UDP-N-acetylglucosamine transferase subunit ALG14 homolog; May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May ancho [...]
CNN3 protein networkhttps://string-db.org/network/9606.ENSP00000359225Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...]
HAUS7 protein networkhttps://string-db.org/network/9606.ENSP00000359230HAUS augmin-like complex subunit 7; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to [...]
ABCD3 protein networkhttps://string-db.org/network/9606.ENSP00000359233ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched- chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial [...]
LZTS2 protein networkhttps://string-db.org/network/9606.ENSP00000359240Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion [...]
ABCA4 protein networkhttps://string-db.org/network/9606.ENSP00000359245Retinal-specific phospholipid-transporting ATPase ABCA4; Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the [...]
GCLM protein networkhttps://string-db.org/network/9606.ENSP00000359258Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily.
ZNF275 protein networkhttps://string-db.org/network/9606.ENSP00000359271Zinc finger protein 275; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CHRNA4 protein networkhttps://string-db.org/network/9606.ENSP00000359285Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
SLF2 protein networkhttps://string-db.org/network/9606.ENSP00000359292SMC5-SMC6 complex localization factor protein 2; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. Th [...]
DR1 protein networkhttps://string-db.org/network/9606.ENSP00000359295Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the f [...]
NSDHL protein networkhttps://string-db.org/network/9606.ENSP00000359297Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. Belongs to the 3-beta-HSD famil [...]
CETN2 protein networkhttps://string-db.org/network/9606.ENSP00000359300Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis [...]
TMED5 protein networkhttps://string-db.org/network/9606.ENSP00000359305Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; invol [...]
CSAG1 protein networkhttps://string-db.org/network/9606.ENSP00000359310Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1.
PAX2 protein networkhttps://string-db.org/network/9606.ENSP00000359319Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
MTF2 protein networkhttps://string-db.org/network/9606.ENSP00000359321Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding [...]
DIPK1A protein networkhttps://string-db.org/network/9606.ENSP00000359333Divergent protein kinase domain 1A.
GABRA3 protein networkhttps://string-db.org/network/9606.ENSP00000359337Gamma-aminobutyric acid receptor subunit alpha-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
CGAS protein networkhttps://string-db.org/network/9606.ENSP00000359339Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the format [...]
NKAIN4 protein networkhttps://string-db.org/network/9606.ENSP00000359340Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Sodium/potassium transporting ATPase interacting 4; Belongs to the NKAIN family.
RPL5 protein networkhttps://string-db.org/network/9606.ENSP0000035934560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNA [...]
GABRE protein networkhttps://string-db.org/network/9606.ENSP00000359353Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
DDX43 protein networkhttps://string-db.org/network/9606.ENSP00000359361Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43.
YTHDF1 protein networkhttps://string-db.org/network/9606.ENSP00000359364YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at in [...]
SEC31B protein networkhttps://string-db.org/network/9606.ENSP00000359370Protein transport protein Sec31B; As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum.
FATE1 protein networkhttps://string-db.org/network/9606.ENSP00000359375Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) [...]
SLC17A9 protein networkhttps://string-db.org/network/9606.ENSP00000359376Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and syna [...]
PRRG3 protein networkhttps://string-db.org/network/9606.ENSP00000359378Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain 3.
SCD protein networkhttps://string-db.org/network/9606.ENSP00000359380Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the [...]
PASD1 protein networkhttps://string-db.org/network/9606.ENSP00000359382Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK-ARN [...]
OOEP protein networkhttps://string-db.org/network/9606.ENSP00000359384Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the [...]
GLMN protein networkhttps://string-db.org/network/9606.ENSP00000359385Glomulin; [Isoform 1]: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (v [...]
VMA21 protein networkhttps://string-db.org/network/9606.ENSP00000359386Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.
KHDC3L protein networkhttps://string-db.org/network/9606.ENSP00000359392KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family.
HMGB3 protein networkhttps://string-db.org/network/9606.ENSP00000359393High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a [...]
DPPA5 protein networkhttps://string-db.org/network/9606.ENSP00000359396Developmental pluripotency-associated 5 protein; Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of ge [...]
BLOC1S2 protein networkhttps://string-db.org/network/9606.ENSP00000359398Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
C1orf146 protein networkhttps://string-db.org/network/9606.ENSP00000359401Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146.
EPHX4 protein networkhttps://string-db.org/network/9606.ENSP00000359410Epoxide hydrolase 4.
KHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000359411KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family.
KHDC1L protein networkhttps://string-db.org/network/9606.ENSP00000359415Putative KHDC1-like protein; KH domain containing 1 like; Belongs to the KHDC1 family.
MTM1 protein networkhttps://string-db.org/network/9606.ENSP00000359423Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate ph [...]
CHUK protein networkhttps://string-db.org/network/9606.ENSP00000359424Inhibitor of nuclear factor kappa-B kinase subunit alpha; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammator [...]
CXorf40B protein networkhttps://string-db.org/network/9606.ENSP00000359434Protein CXorf40B.
HSFX1 protein networkhttps://string-db.org/network/9606.ENSP00000359444Heat shock transcription factor family, X-linked 1.
CPN1 protein networkhttps://string-db.org/network/9606.ENSP00000359446Carboxypeptidase N catalytic chain; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into [...]
HFM1 protein networkhttps://string-db.org/network/9606.ENSP00000359454Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis.
OGFRL1 protein networkhttps://string-db.org/network/9606.ENSP00000359464Opioid growth factor receptor like 1.
ZNF644 protein networkhttps://string-db.org/network/9606.ENSP00000359469Zinc finger protein 644; May be involved in transcriptional regulation.
BARHL2 protein networkhttps://string-db.org/network/9606.ENSP00000359474BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes.
LRRC8C protein networkhttps://string-db.org/network/9606.ENSP00000359483Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...]
SMAP1 protein networkhttps://string-db.org/network/9606.ENSP00000359484Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).
GBP6 protein networkhttps://string-db.org/network/9606.ENSP00000359485Guanylate-binding protein 6; Binds GTP, GDP and GMP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
GBP5 protein networkhttps://string-db.org/network/9606.ENSP00000359488Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microb [...]
AFF2 protein networkhttps://string-db.org/network/9606.ENSP00000359489AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
GBP4 protein networkhttps://string-db.org/network/9606.ENSP00000359490Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).
GBP2 protein networkhttps://string-db.org/network/9606.ENSP00000359497Guanylate-binding protein 2; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidat [...]
FMR1NB protein networkhttps://string-db.org/network/9606.ENSP00000359498Fragile X mental retardation 1 neighbor protein; FMR1 neighbor.
GBP1 protein networkhttps://string-db.org/network/9606.ENSP00000359504Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial [...]
SDHAF4 protein networkhttps://string-db.org/network/9606.ENSP00000359505Succinate dehydrogenase assembly factor 4, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...]
FMR1 protein networkhttps://string-db.org/network/9606.ENSP00000359506Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of [...]
CUTC protein networkhttps://string-db.org/network/9606.ENSP00000359507Copper homeostasis protein cutC homolog; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit.
GBP3 protein networkhttps://string-db.org/network/9606.ENSP00000359512Guanylate-binding protein 3; Exhibits antiviral activity against influenza virus.
MRGBP protein networkhttps://string-db.org/network/9606.ENSP00000359518MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal [...]
ENTPD7 protein networkhttps://string-db.org/network/9606.ENSP00000359520Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP.
SPANXN1 protein networkhttps://string-db.org/network/9606.ENSP00000359524Sperm protein associated with the nucleus on the X chromosome N1; SPANX family member N1; Belongs to the SPAN-X family.
SLC25A28 protein networkhttps://string-db.org/network/9606.ENSP00000359526Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered i [...]
GTF2B protein networkhttps://string-db.org/network/9606.ENSP00000359531Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formati [...]
NTSR1 protein networkhttps://string-db.org/network/9606.ENSP00000359532Neurotensin receptor type 1; G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenge [...]
SPANXN3 protein networkhttps://string-db.org/network/9606.ENSP00000359534Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family.
GOT1 protein networkhttps://string-db.org/network/9606.ENSP00000359539Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the verte [...]
CREG1 protein networkhttps://string-db.org/network/9606.ENSP00000359540Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. [...]
SPANXD protein networkhttps://string-db.org/network/9606.ENSP00000359546Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family.
SPANXA2 protein networkhttps://string-db.org/network/9606.ENSP00000359549Sperm protein associated with the nucleus on the X chromosome A; SPANX family member A2; Belongs to the SPAN-X family.
SPANXA1 protein networkhttps://string-db.org/network/9606.ENSP00000359550Sperm protein associated with the nucleus, X-linked, family member A1.
PKN2 protein networkhttps://string-db.org/network/9606.ENSP00000359552Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role [...]
LDOC1 protein networkhttps://string-db.org/network/9606.ENSP00000359557Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family.
CDR1 protein networkhttps://string-db.org/network/9606.ENSP00000359563Cerebellar degeneration related protein 1.
SOX3 protein networkhttps://string-db.org/network/9606.ENSP00000359567Transcription factor SOX-3; Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferenti [...]
CXorf66 protein networkhttps://string-db.org/network/9606.ENSP00000359571Uncharacterized protein CXorf66; Chromosome X open reading frame 66.
LMO4 protein networkhttps://string-db.org/network/9606.ENSP00000359575LIM domain transcription factor LMO4; Probable transcriptional factor.
HS2ST1-2 protein networkhttps://string-db.org/network/9606.ENSP00000359579Heparan sulfate 2-O-sulfotransferase 1.
HS2ST1 protein networkhttps://string-db.org/network/9606.ENSP00000359581Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, [...]
HPSE2 protein networkhttps://string-db.org/network/9606.ENSP00000359583Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro).
CLCA4 protein networkhttps://string-db.org/network/9606.ENSP00000359594Calcium-activated chloride channel regulator 4, 110 kDa form; May be involved in mediating calcium-activated chloride conductance.
CLCA2 protein networkhttps://string-db.org/network/9606.ENSP00000359596Calcium-activated chloride channel regulator 2, 109 kDa form; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in [...]
ODF2L protein networkhttps://string-db.org/network/9606.ENSP00000359600Protein BCAP; Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis; Belongs to the ODF2 family.
COL24A1 protein networkhttps://string-db.org/network/9606.ENSP00000359603Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. Belongs to the fibrillar collagen family.
ZNHIT6 protein networkhttps://string-db.org/network/9606.ENSP00000359606Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family.
PYROXD2 protein networkhttps://string-db.org/network/9606.ENSP00000359607Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase; Belongs to the carotenoid/retinoid oxidoreductase family.
MCOLN3 protein networkhttps://string-db.org/network/9606.ENSP00000359621Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying a [...]
CRTAC1 protein networkhttps://string-db.org/network/9606.ENSP00000359629Cartilage acidic protein 1.
ADGRB3 protein networkhttps://string-db.org/network/9606.ENSP00000359630Adhesion G protein-coupled receptor B3; Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity ( [...]
GOLGA7B protein networkhttps://string-db.org/network/9606.ENSP00000359634Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family.
MCOLN2 protein networkhttps://string-db.org/network/9606.ENSP00000359640Mucolipin-2; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May a [...]
LPAR3 protein networkhttps://string-db.org/network/9606.ENSP00000359643Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to [...]
RBMX protein networkhttps://string-db.org/network/9606.ENSP00000359645RNA-binding motif protein, X chromosome, N-terminally processed; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- sp [...]
EYS protein networkhttps://string-db.org/network/9606.ENSP00000359655Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate pr [...]
AVPI1 protein networkhttps://string-db.org/network/9606.ENSP00000359660Arginine vasopressin-induced protein 1; May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.
CD40LG protein networkhttps://string-db.org/network/9606.ENSP00000359663CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signa [...]
CTBS protein networkhttps://string-db.org/network/9606.ENSP00000359664Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of [...]
PI4K2A protein networkhttps://string-db.org/network/9606.ENSP00000359665Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-pho [...]
VGLL1 protein networkhttps://string-db.org/network/9606.ENSP00000359668Transcription cofactor vestigial-like protein 1; May act as a specific coactivator for the mammalian TEFs. Belongs to the vestigial family.
C10orf62 protein networkhttps://string-db.org/network/9606.ENSP00000359674Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62.
GNG5 protein networkhttps://string-db.org/network/9606.ENSP00000359675Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
HOGA1 protein networkhttps://string-db.org/network/9606.ENSP000003596804-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family.
BRS3 protein networkhttps://string-db.org/network/9606.ENSP00000359682Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium se [...]
RPF1 protein networkhttps://string-db.org/network/9606.ENSP00000359688Ribosome production factor 1; May be required for ribosome biogenesis.
LGSN protein networkhttps://string-db.org/network/9606.ENSP00000359691Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have e [...]
FKBP1C protein networkhttps://string-db.org/network/9606.ENSP00000359693FKBP prolyl isomerase 1C.
UBTD1 protein networkhttps://string-db.org/network/9606.ENSP00000359698Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the sta [...]
DNASE2B protein networkhttps://string-db.org/network/9606.ENSP00000359699Deoxyribonuclease-2-beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.
SAMD13 protein networkhttps://string-db.org/network/9606.ENSP00000359707Sterile alpha motif domain containing 13.
PRKACB protein networkhttps://string-db.org/network/9606.ENSP00000359719cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell pr [...]
BAG2 protein networkhttps://string-db.org/network/9606.ENSP00000359727BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...]
SLC9A6 protein networkhttps://string-db.org/network/9606.ENSP00000359729Sodium/hydrogen exchanger 6; Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
ZNF451 protein networkhttps://string-db.org/network/9606.ENSP00000359740E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modif [...]
ADGRL2 protein networkhttps://string-db.org/network/9606.ENSP00000359765Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exo [...]
KIAA1586 protein networkhttps://string-db.org/network/9606.ENSP00000359768E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins.
ADGRL4 protein networkhttps://string-db.org/network/9606.ENSP00000359778Adhesion G protein-coupled receptor L4; Endothelial orphan receptor that acts as a key regulator of angiogenesis.
BEND6 protein networkhttps://string-db.org/network/9606.ENSP00000359782BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-ren [...]
IFI44 protein networkhttps://string-db.org/network/9606.ENSP00000359783Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family.
IFI44L protein networkhttps://string-db.org/network/9606.ENSP00000359787Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family.
PTGFR protein networkhttps://string-db.org/network/9606.ENSP00000359793Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second mes [...]
GIPC2 protein networkhttps://string-db.org/network/9606.ENSP00000359795PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family.
DNAJB4 protein networkhttps://string-db.org/network/9606.ENSP00000359799DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).
ZNF75D protein networkhttps://string-db.org/network/9606.ENSP00000359802Zinc finger protein 75D; May be involved in transcriptional regulation.
FUBP1 protein networkhttps://string-db.org/network/9606.ENSP00000359804Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far- upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor [...]
MMS19 protein networkhttps://string-db.org/network/9606.ENSP00000359818MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur [...]
MOSPD1 protein networkhttps://string-db.org/network/9606.ENSP00000359819Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). H [...]
FAM122C protein networkhttps://string-db.org/network/9606.ENSP00000359820Protein FAM122C; Family with sequence similarity 122C.
USP33 protein networkhttps://string-db.org/network/9606.ENSP00000359829Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. [...]
ZZZ3 protein networkhttps://string-db.org/network/9606.ENSP00000359837ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
PIGK protein networkhttps://string-db.org/network/9606.ENSP00000359848GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidatio [...]
MTG2 protein networkhttps://string-db.org/network/9606.ENSP00000359859Mitochondrial ribosome-associated GTPase 2; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome [...]
GPC4 protein networkhttps://string-db.org/network/9606.ENSP00000359864Secreted glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity).
BMP5 protein networkhttps://string-db.org/network/9606.ENSP00000359866Bone morphogenetic protein 5; Induces cartilage and bone formation.
ACADM protein networkhttps://string-db.org/network/9606.ENSP00000359871Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utiliz [...]
MBNL3 protein networkhttps://string-db.org/network/9606.ENSP00000359890Muscleblind-like protein 3; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...]
SLC44A5 protein networkhttps://string-db.org/network/9606.ENSP00000359892Choline transporter-like protein 5; Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family.
TYW3 protein networkhttps://string-db.org/network/9606.ENSP00000359904tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper [...]
PSMA7 protein networkhttps://string-db.org/network/9606.ENSP00000359910Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
RAP2C protein networkhttps://string-db.org/network/9606.ENSP00000359911Ras-related protein Rap-2c; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell sprea [...]
LRRC1 protein networkhttps://string-db.org/network/9606.ENSP00000359925Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1.
FPGT protein networkhttps://string-db.org/network/9606.ENSP00000359935Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover [...]
EXOSC1 protein networkhttps://string-db.org/network/9606.ENSP00000359939Exosome complex component CSL4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...]
IGSF1 protein networkhttps://string-db.org/network/9606.ENSP00000359940Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absenc [...]
KLHL31 protein networkhttps://string-db.org/network/9606.ENSP00000359942Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response elem [...]
ELOVL5 protein networkhttps://string-db.org/network/9606.ENSP00000359956Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
ZRANB2 protein networkhttps://string-db.org/network/9606.ENSP00000359958Zinc finger Ran-binding domain-containing protein 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.
CTH protein networkhttps://string-db.org/network/9606.ENSP00000359976Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2 [...]
HHLA3 protein networkhttps://string-db.org/network/9606.ENSP00000359978HERV-H LTR-associating 3.
ANKRD13C protein networkhttps://string-db.org/network/9606.ENSP00000359982Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.
SRSF11 protein networkhttps://string-db.org/network/9606.ENSP00000359988Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing.
LRRC40 protein networkhttps://string-db.org/network/9606.ENSP00000359990Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40.
PGAM1 protein networkhttps://string-db.org/network/9606.ENSP00000359991Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but w [...]
GSTA4 protein networkhttps://string-db.org/network/9606.ENSP00000360002Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydrox [...]
ZNF280C protein networkhttps://string-db.org/network/9606.ENSP00000360017Zinc finger protein 280C; May function as a transcription factor.
DIRAS3 protein networkhttps://string-db.org/network/9606.ENSP00000360020GTP-binding protein Di-Ras3; DIRAS family GTPase 3.
GNG12 protein networkhttps://string-db.org/network/9606.ENSP00000360021Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...]
GADD45A protein networkhttps://string-db.org/network/9606.ENSP00000360025Growth arrest and DNA damage-inducible protein GADD45 alpha; In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA in [...]
GSTA5 protein networkhttps://string-db.org/network/9606.ENSP00000360028Glutathione S-transferase alpha 5.
SERBP1 protein networkhttps://string-db.org/network/9606.ENSP00000360034Plasminogen activator inhibitor 1 RNA-binding protein; May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nu [...]
PPP1R3D protein networkhttps://string-db.org/network/9606.ENSP00000360035Protein phosphatase 1 regulatory subunit 3D; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, m [...]
C1orf141 protein networkhttps://string-db.org/network/9606.ENSP00000360046Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141.
PHACTR3 protein networkhttps://string-db.org/network/9606.ENSP00000360054Phosphatase and actin regulator 3.
FRAT2 protein networkhttps://string-db.org/network/9606.ENSP00000360058GSK-3-binding protein FRAT2; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3; Belongs to the GSK-3-binding protein family.
FRAT1 protein networkhttps://string-db.org/network/9606.ENSP00000360060Proto-oncogene FRAT1; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 [...]
WDR78 protein networkhttps://string-db.org/network/9606.ENSP00000360065WD repeat-containing protein 78.
SGIP1 protein networkhttps://string-db.org/network/9606.ENSP00000360076SH3-containing GRB2-like protein 3-interacting protein 1; May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essent [...]
EFHC1 protein networkhttps://string-db.org/network/9606.ENSP00000360107EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. N [...]
DNAJC6 protein networkhttps://string-db.org/network/9606.ENSP00000360108Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis [...]
RAVER2 protein networkhttps://string-db.org/network/9606.ENSP00000360112Ribonucleoprotein PTB-binding 2; May bind single-stranded nucleic acids.
UBE2U protein networkhttps://string-db.org/network/9606.ENSP00000360116Ubiquitin-conjugating enzyme E2 U; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family.
ROR1 protein networkhttps://string-db.org/network/9606.ENSP00000360120Inactive tyrosine-protein kinase transmembrane receptor ROR1; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activ [...]
PGM1 protein networkhttps://string-db.org/network/9606.ENSP00000360124Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
EFCAB7 protein networkhttps://string-db.org/network/9606.ENSP00000360129EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcompl [...]
ITGB3BP protein networkhttps://string-db.org/network/9606.ENSP00000360133Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors f [...]
GNAS protein networkhttps://string-db.org/network/9606.ENSP00000360141Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protei [...]
XPNPEP2 protein networkhttps://string-db.org/network/9606.ENSP00000360147Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the me [...]
OCRL protein networkhttps://string-db.org/network/9606.ENSP00000360154Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphat [...]
FOXD3 protein networkhttps://string-db.org/network/9606.ENSP00000360157Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural [...]
PKHD1 protein networkhttps://string-db.org/network/9606.ENSP00000360158Fibrocystin; May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duc [...]
SMARCA1 protein networkhttps://string-db.org/network/9606.ENSP00000360162Probable global transcription activator SNF2L1; Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilit [...]
ACTRT1 protein networkhttps://string-db.org/network/9606.ENSP00000360165Actin-related protein T1; Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family.
PRR32 protein networkhttps://string-db.org/network/9606.ENSP00000360166Proline-rich protein 32; Proline rich 32.
DCAF12L1 protein networkhttps://string-db.org/network/9606.ENSP00000360167DDB1- and CUL4-associated factor 12-like protein 1; DDB1 and CUL4 associated factor 12 like 1.
ANGPTL3 protein networkhttps://string-db.org/network/9606.ENSP00000360170Angiopoietin-related protein 3; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to eit [...]
SH2D1A protein networkhttps://string-db.org/network/9606.ENSP00000360181SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In S [...]
STX16 protein networkhttps://string-db.org/network/9606.ENSP00000360183Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
TM9SF3 protein networkhttps://string-db.org/network/9606.ENSP00000360184Transmembrane 9 superfamily member 3.
DEFB110 protein networkhttps://string-db.org/network/9606.ENSP00000360190Beta-defensin 110; Has antibacterial activity.
APCDD1L protein networkhttps://string-db.org/network/9606.ENSP00000360191Protein APCDD1-like; APC down-regulated 1 like.
KANK4 protein networkhttps://string-db.org/network/9606.ENSP00000360195KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization.
C20orf85 protein networkhttps://string-db.org/network/9606.ENSP00000360210Uncharacterized protein C20orf85; Chromosome 20 open reading frame 85.
OPALIN protein networkhttps://string-db.org/network/9606.ENSP00000360214Opalin; Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
ZBP1 protein networkhttps://string-db.org/network/9606.ENSP00000360215Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathoge [...]
DNTT protein networkhttps://string-db.org/network/9606.ENSP00000360216DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo func [...]
RHAG protein networkhttps://string-db.org/network/9606.ENSP00000360217Ammonium transporter Rh type A; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythroc [...]
NFIA protein networkhttps://string-db.org/network/9606.ENSP00000360231Nuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...]
GLYATL3 protein networkhttps://string-db.org/network/9606.ENSP00000360240Glycine N-acyltransferase-like protein 3; Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary [...]
XIAP protein networkhttps://string-db.org/network/9606.ENSP00000360242E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic k [...]
C1orf87 protein networkhttps://string-db.org/network/9606.ENSP00000360244Uncharacterized protein C1orf87; Chromosome 1 open reading frame 87.
CYP2J2 protein networkhttps://string-db.org/network/9606.ENSP00000360247Cytochrome P450 2J2; A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system. Mechanistically, uses molecular oxygen insertin [...]
ENTPD1 protein networkhttps://string-db.org/network/9606.ENSP00000360250Ectonucleoside triphosphate diphosphohydrolase 1; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the preven [...]
HOOK1 protein networkhttps://string-db.org/network/9606.ENSP00000360252Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (B [...]
OPN5 protein networkhttps://string-db.org/network/9606.ENSP00000360255Opsin-5; Opsin 5.
FGGY protein networkhttps://string-db.org/network/9606.ENSP00000360262FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family.
JUN protein networkhttps://string-db.org/network/9606.ENSP00000360266Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to incre [...]
ALDH18A1 protein networkhttps://string-db.org/network/9606.ENSP00000360268Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
TACSTD2 protein networkhttps://string-db.org/network/9606.ENSP00000360269Tumor-associated calcium signal transducer 2; May function as a growth factor receptor; Belongs to the EPCAM family.
OMA1 protein networkhttps://string-db.org/network/9606.ENSP00000360270Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitocho [...]
DAB1 protein networkhttps://string-db.org/network/9606.ENSP00000360280Disabled homolog 1; Adapter molecule functioning in neural development. May regulate SIAH1 activity.
C8B protein networkhttps://string-db.org/network/9606.ENSP00000360281Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of ta [...]
PRKAA2 protein networkhttps://string-db.org/network/9606.ENSP000003602905'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular e [...]
SORBS1 protein networkhttps://string-db.org/network/9606.ENSP00000360293Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in [...]
PLPP3 protein networkhttps://string-db.org/network/9606.ENSP00000360296Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate este [...]
ADGRF1 protein networkhttps://string-db.org/network/9606.ENSP00000360299Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
PDLIM1 protein networkhttps://string-db.org/network/9606.ENSP00000360305PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of [...]
SPO11 protein networkhttps://string-db.org/network/9606.ENSP00000360310Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-stra [...]
TMEM61 protein networkhttps://string-db.org/network/9606.ENSP00000360315Transmembrane protein 61.
DHCR24 protein networkhttps://string-db.org/network/9606.ENSP00000360316Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can [...]
CYP2C8 protein networkhttps://string-db.org/network/9606.ENSP00000360317Cytochrome P450 2C8; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molec [...]
LEXM protein networkhttps://string-db.org/network/9606.ENSP00000360320Lymphocyte expansion molecule.
TTC22 protein networkhttps://string-db.org/network/9606.ENSP00000360323Tetratricopeptide repeat domain 22.
PARS2 protein networkhttps://string-db.org/network/9606.ENSP00000360327Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial.
TTC4 protein networkhttps://string-db.org/network/9606.ENSP00000360329Tetratricopeptide repeat protein 4; May act as a co-chaperone for HSP90AB1. Promotes Sendai virus (SeV)-induced host cell innate immune responses.
CT47B1 protein networkhttps://string-db.org/network/9606.ENSP00000360360Cancer/testis antigen family 47 member B1.
MCTS1 protein networkhttps://string-db.org/network/9606.ENSP00000360365Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit t [...]
ACOT11 protein networkhttps://string-db.org/network/9606.ENSP00000360366Acyl-coenzyme A thioesterase 11; Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoy [...]
SSBP3 protein networkhttps://string-db.org/network/9606.ENSP00000360371Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter r [...]
CYP2C19 protein networkhttps://string-db.org/network/9606.ENSP00000360372Cytochrome P450 2C19; A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA). Mechanistically, uses molecular oxygen inserting one oxygen atom into a sub [...]
FAM209B protein networkhttps://string-db.org/network/9606.ENSP00000360376Protein FAM209B; Family with sequence similarity 209 member B.
FAM209A protein networkhttps://string-db.org/network/9606.ENSP00000360379Protein FAM209A; Family with sequence similarity 209 member A.
SLC25A27 protein networkhttps://string-db.org/network/9606.ENSP00000360398Mitochondrial uncoupling protein 4; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP [...]
LDLRAD1 protein networkhttps://string-db.org/network/9606.ENSP00000360411Low density lipoprotein receptor class A domain containing 1.
NOC3L protein networkhttps://string-db.org/network/9606.ENSP00000360412Nucleolar complex protein 3 homolog; May be required for adipogenesis.
LRRC42 protein networkhttps://string-db.org/network/9606.ENSP00000360421Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family.
CACNA1B protein networkhttps://string-db.org/network/9606.ENSP00000360423Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...]
RCAN2 protein networkhttps://string-db.org/network/9606.ENSP00000360425Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs [...]
PLCE1 protein networkhttps://string-db.org/network/9606.ENSP000003604311-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by ac [...]
ENPP5 protein networkhttps://string-db.org/network/9606.ENSP00000360436Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuro [...]
FAM210B protein networkhttps://string-db.org/network/9606.ENSP00000360437Protein FAM210B, mitochondrial; Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cell [...]
RHOXF2 protein networkhttps://string-db.org/network/9606.ENSP00000360441Rhox homeobox family member 2; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogene [...]
RHOXF2B protein networkhttps://string-db.org/network/9606.ENSP00000360455Rhox homeobox family member 2B; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogen [...]
NKAP protein networkhttps://string-db.org/network/9606.ENSP00000360464NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in [...]
LGI1 protein networkhttps://string-db.org/network/9606.ENSP00000360472Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure medi [...]
PFDN4 protein networkhttps://string-db.org/network/9606.ENSP00000360473Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
ARRDC1 protein networkhttps://string-db.org/network/9606.ENSP00000360475Arrestin domain-containing protein 1; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a [...]
NDC1 protein networkhttps://string-db.org/network/9606.ENSP00000360483Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assem [...]
AKAP14 protein networkhttps://string-db.org/network/9606.ENSP00000360485A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
FRA10AC1 protein networkhttps://string-db.org/network/9606.ENSP00000360488Protein FRA10AC1; FRA10A associated CGG repeat 1.
NDUFA1 protein networkhttps://string-db.org/network/9606.ENSP00000360492NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
RUNX2 protein networkhttps://string-db.org/network/9606.ENSP00000360493Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous [...]
RNF113A protein networkhttps://string-db.org/network/9606.ENSP00000360497E3 ubiquitin-protein ligase RNF113A; Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Cat [...]
MRPL41 protein networkhttps://string-db.org/network/9606.ENSP0000036049839S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p5 [...]
DMRTB1 protein networkhttps://string-db.org/network/9606.ENSP00000360500Doublesex- and mab-3-related transcription factor B1; DMRT like family B with proline rich C-terminal 1; Belongs to the DMRT family.
PDE6C protein networkhttps://string-db.org/network/9606.ENSP00000360502Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decre [...]
SUPT3H protein networkhttps://string-db.org/network/9606.ENSP00000360515Transcription initiation protein SPT3 homolog; Probable transcriptional activator.
RBP4 protein networkhttps://string-db.org/network/9606.ENSP00000360522Plasma retinol-binding protein(1-176); Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transf [...]
MAGOH protein networkhttps://string-db.org/network/9606.ENSP00000360525Protein mago nashi homolog; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nons [...]
ZNF217 protein networkhttps://string-db.org/network/9606.ENSP00000360526Zinc finger protein 217; Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
NSMF protein networkhttps://string-db.org/network/9606.ENSP00000360530NMDA receptor synaptonuclear signaling and neuronal migration factor; Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture [...]
CDC5L protein networkhttps://string-db.org/network/9606.ENSP00000360532Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, ca [...]
FFAR4 protein networkhttps://string-db.org/network/9606.ENSP00000360538Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust a [...]
CEP55 protein networkhttps://string-db.org/network/9606.ENSP00000360540Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not requ [...]
CPT2 protein networkhttps://string-db.org/network/9606.ENSP00000360541Carnitine O-palmitoyltransferase 2, mitochondrial; Carnitine palmitoyltransferase 2.
TSHZ2 protein networkhttps://string-db.org/network/9606.ENSP00000360552Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger prote [...]
TCTE1 protein networkhttps://string-db.org/network/9606.ENSP00000360560Dynein regulatory complex subunit 5; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dist [...]
ENTPD8 protein networkhttps://string-db.org/network/9606.ENSP00000360561Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- a [...]
SCP2 protein networkhttps://string-db.org/network/9606.ENSP00000360569Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.
NDOR1 protein networkhttps://string-db.org/network/9606.ENSP00000360576NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By simi [...]
ECHDC2 protein networkhttps://string-db.org/network/9606.ENSP00000360577Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family.
ZYG11A protein networkhttps://string-db.org/network/9606.ENSP00000360583Protein zyg-11 homolog A; Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC; Belongs to the zyg-11 family.
COA7 protein networkhttps://string-db.org/network/9606.ENSP00000360593Cytochrome c oxidase assembly factor 7; Required for assembly of mitochondrial respiratory chain complex I and complex IV; Belongs to the hcp beta-lactamase family.
LRRC26 protein networkhttps://string-db.org/network/9606.ENSP00000360597Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels [...]
GRIN1 protein networkhttps://string-db.org/network/9606.ENSP00000360608Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensi [...]
HSP90AB1 protein networkhttps://string-db.org/network/9606.ENSP00000360609Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle cont [...]
UBE2A protein networkhttps://string-db.org/network/9606.ENSP00000360613Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it p [...]
ORC1 protein networkhttps://string-db.org/network/9606.ENSP00000360623Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of r [...]
KCNG1 protein networkhttps://string-db.org/network/9606.ENSP00000360626Potassium voltage-gated channel subfamily G member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...]
DPP7 protein networkhttps://string-db.org/network/9606.ENSP00000360635Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides.
DPM1 protein networkhttps://string-db.org/network/9606.ENSP00000360638Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathwa [...]
CC2D1B protein networkhttps://string-db.org/network/9606.ENSP00000360642Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells.
MAN1B1 protein networkhttps://string-db.org/network/9606.ENSP00000360645Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single al [...]
NPDC1 protein networkhttps://string-db.org/network/9606.ENSP00000360660Neural proliferation differentiation and control protein 1; Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in t [...]
ADNP protein networkhttps://string-db.org/network/9606.ENSP00000360662Activity-dependent neuroprotector homeobox protein; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proli [...]
BTF3L4 protein networkhttps://string-db.org/network/9606.ENSP00000360664Basic transcription factor 3 like 4; Belongs to the NAC-beta family.
SLC25A5 protein networkhttps://string-db.org/network/9606.ENSP00000360671ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated [...]
PARD6B protein networkhttps://string-db.org/network/9606.ENSP00000360672Partitioning defective 6 homolog beta; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Associ [...]
KTI12 protein networkhttps://string-db.org/network/9606.ENSP00000360676KTI12 chromatin associated homolog.
PAXX protein networkhttps://string-db.org/network/9606.ENSP00000360682Protein PAXX; Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRC [...]
PTPN1 protein networkhttps://string-db.org/network/9606.ENSP00000360683Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/ [...]
PTGDS protein networkhttps://string-db.org/network/9606.ENSP00000360687Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved i [...]
TXNDC12 protein networkhttps://string-db.org/network/9606.ENSP00000360688Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity.
TNKS2 protein networkhttps://string-db.org/network/9606.ENSP00000360689Poly [ADP-ribose] polymerase tankyrase-2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of [...]
LONRF3 protein networkhttps://string-db.org/network/9606.ENSP00000360690LON peptidase N-terminal domain and ring finger 3.
LCN12 protein networkhttps://string-db.org/network/9606.ENSP00000360696Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity).
C8G protein networkhttps://string-db.org/network/9606.ENSP00000360697Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the pol [...]
TMEM189 protein networkhttps://string-db.org/network/9606.ENSP00000360715Plasmanylethanolamine desaturase; Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarb [...]
RAB3B protein networkhttps://string-db.org/network/9606.ENSP00000360718Ras-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
RABL6 protein networkhttps://string-db.org/network/9606.ENSP00000360727Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A.
IL13RA1 protein networkhttps://string-db.org/network/9606.ENSP00000360730Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory prote [...]
DIPK1B protein networkhttps://string-db.org/network/9606.ENSP00000360757Divergent protein kinase domain 1B; Belongs to the DIPK family.
AGPAT2 protein networkhttps://string-db.org/network/9606.ENSP000003607611-acyl-sn-glycerol-3-phosphate acyltransferase beta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by in [...]
ANKRD1 protein networkhttps://string-db.org/network/9606.ENSP00000360762Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardia [...]
EGFL7 protein networkhttps://string-db.org/network/9606.ENSP00000360764Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet- derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial [...]
B4GALT5 protein networkhttps://string-db.org/network/9606.ENSP00000360776Beta-1,4-galactosyltransferase 5; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point [...]
INPP5E protein networkhttps://string-db.org/network/9606.ENSP00000360777Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIn [...]
PMPCA protein networkhttps://string-db.org/network/9606.ENSP00000360782Mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off [...]
KIF20B protein networkhttps://string-db.org/network/9606.ENSP00000360793Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cell [...]
CARD9 protein networkhttps://string-db.org/network/9606.ENSP00000360797Caspase recruitment domain-containing protein 9; Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is [...]
EPS15 protein networkhttps://string-db.org/network/9606.ENSP00000360798Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the intern [...]
DNLZ protein networkhttps://string-db.org/network/9606.ENSP00000360803DNL-type zinc finger protein; May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.
KCNB1 protein networkhttps://string-db.org/network/9606.ENSP00000360806Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in t [...]
LHX3 protein networkhttps://string-db.org/network/9606.ENSP00000360811LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin p [...]
ZNFX1 protein networkhttps://string-db.org/network/9606.ENSP00000360817Zinc finger NFX1-type containing 1.
UBAC1 protein networkhttps://string-db.org/network/9606.ENSP00000360821Ubiquitin-associated domain-containing protein 1; Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degra [...]
KCNT1 protein networkhttps://string-db.org/network/9606.ENSP00000360822Potassium channel subfamily T member 1; Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride [...]
C1orf185 protein networkhttps://string-db.org/network/9606.ENSP00000360824Uncharacterized protein C1orf185; Chromosome 1 open reading frame 185.
GLT6D1 protein networkhttps://string-db.org/network/9606.ENSP00000360829Glycosyltransferase 6 domain containing 1; Belongs to the glycosyltransferase 6 family.
MRPS2 protein networkhttps://string-db.org/network/9606.ENSP0000036085028S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.
SLC16A12 protein networkhttps://string-db.org/network/9606.ENSP00000360855Monocarboxylate transporter 12; Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane.
OLFM1 protein networkhttps://string-db.org/network/9606.ENSP00000360858Noelin; Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth c [...]
IFIT5 protein networkhttps://string-db.org/network/9606.ENSP00000360860Interferon-induced protein with tetratricopeptide repeats 5; Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recogniti [...]
IFIT1 protein networkhttps://string-db.org/network/9606.ENSP00000360869Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA) [...]
FCN1 protein networkhttps://string-db.org/network/9606.ENSP00000360871Ficolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes [...]
IFIT1B protein networkhttps://string-db.org/network/9606.ENSP00000360874Interferon induced protein with tetratricopeptide repeats 1B.
IFIT3 protein networkhttps://string-db.org/network/9606.ENSP00000360876Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signal [...]
COL5A1 protein networkhttps://string-db.org/network/9606.ENSP00000360882Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...]
BEND5 protein networkhttps://string-db.org/network/9606.ENSP00000360899BEN domain-containing protein 5; Acts as a transcriptional repressor.
AGBL4 protein networkhttps://string-db.org/network/9606.ENSP00000360905Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...]
SPATA6 protein networkhttps://string-db.org/network/9606.ENSP00000360913Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the h [...]
VAV2 protein networkhttps://string-db.org/network/9606.ENSP00000360916Guanine nucleotide exchange factor VAV2; Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated [...]
CH25H protein networkhttps://string-db.org/network/9606.ENSP00000360918Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and moveme [...]
STAU1 protein networkhttps://string-db.org/network/9606.ENSP00000360922Double-stranded RNA-binding protein Staufen homolog 1; Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the c [...]
SARDH protein networkhttps://string-db.org/network/9606.ENSP00000360938Sarcosine dehydrogenase, mitochondrial; Sarcosine dehydrogenase; Belongs to the GcvT family.
CMPK1 protein networkhttps://string-db.org/network/9606.ENSP00000360939UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference [...]
STIL protein networkhttps://string-db.org/network/9606.ENSP00000360944SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survi [...]
CYP4A22 protein networkhttps://string-db.org/network/9606.ENSP00000360958Cytochrome P450 4A22; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks [...]
CT83 protein networkhttps://string-db.org/network/9606.ENSP00000360961Kita-kyushu lung cancer antigen 1; Cancer/testis antigen 83.
SLC2A6 protein networkhttps://string-db.org/network/9606.ENSP00000360966Solute carrier family 2, facilitated glucose transporter member 6; Probable sugar transporter that acts as a regulator of glycolysis in macrophages (Probable). Does not transport glucose.
CYP4X1 protein networkhttps://string-db.org/network/9606.ENSP00000360968Cytochrome P450 4X1; A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannab [...]
AGTR2 protein networkhttps://string-db.org/network/9606.ENSP00000360973Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
ARFGEF2 protein networkhttps://string-db.org/network/9606.ENSP00000360985Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF [...]
LUZP4 protein networkhttps://string-db.org/network/9606.ENSP00000360988Leucine zipper protein 4; Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA expor [...]
CYP4B1 protein networkhttps://string-db.org/network/9606.ENSP00000360991Cytochrome P450 4B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...]
STAMBPL1 protein networkhttps://string-db.org/network/9606.ENSP00000360992AMSH-like protease; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains; Belongs to the peptidase M67C famil [...]
ADAMTS13 protein networkhttps://string-db.org/network/9606.ENSP00000360997A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
ANKRD22 protein networkhttps://string-db.org/network/9606.ENSP00000360998Ankyrin repeat domain 22.
EFCAB14 protein networkhttps://string-db.org/network/9606.ENSP00000361001EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14.
IL13RA2 protein networkhttps://string-db.org/network/9606.ENSP00000361004Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
LIPJ protein networkhttps://string-db.org/network/9606.ENSP00000361007Lipase family member J; Belongs to the AB hydrolase superfamily. Lipase family.
PREX1 protein networkhttps://string-db.org/network/9606.ENSP00000361009Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP f [...]
REXO4 protein networkhttps://string-db.org/network/9606.ENSP00000361010REX4 homolog, 3'-5' exonuclease.
PTEN protein networkhttps://string-db.org/network/9606.ENSP00000361021Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid [...]
STKLD1 protein networkhttps://string-db.org/network/9606.ENSP00000361025Serine/threonine kinase-like domain-containing protein STKLD1; Serine/threonine kinase like domain containing 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL sub [...]
AMOT protein networkhttps://string-db.org/network/9606.ENSP00000361027Angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regula [...]
SURF2 protein networkhttps://string-db.org/network/9606.ENSP00000361032Surfeit 2; Belongs to the SURF2 family.
LHFPL1 protein networkhttps://string-db.org/network/9606.ENSP00000361036LHFPL tetraspan subfamily member 1.
SURF1 protein networkhttps://string-db.org/network/9606.ENSP00000361042Surfeit locus protein 1; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly [...]
RAD54L protein networkhttps://string-db.org/network/9606.ENSP00000361043DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotei [...]
LURAP1 protein networkhttps://string-db.org/network/9606.ENSP00000361048Leucine rich adaptor protein 1; Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming fu [...]
SURF4 protein networkhttps://string-db.org/network/9606.ENSP00000361057Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family.
POMGNT1 protein networkhttps://string-db.org/network/9606.ENSP00000361060Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoprotein [...]
MINPP1 protein networkhttps://string-db.org/network/9606.ENSP00000361064Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol h [...]
NCOA3 protein networkhttps://string-db.org/network/9606.ENSP00000361066Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central r [...]
TSPAN1 protein networkhttps://string-db.org/network/9606.ENSP00000361072Tetraspanin-1; Tetraspanin 1.
RPL7A protein networkhttps://string-db.org/network/9606.ENSP00000361076Ribosomal protein L7a.
ADIRF protein networkhttps://string-db.org/network/9606.ENSP00000361083Adipogenesis regulatory factor; Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEB [...]
MRPL14 protein networkhttps://string-db.org/network/9606.ENSP0000036108439S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome form [...]
SNCG protein networkhttps://string-db.org/network/9606.ENSP00000361087Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of [...]
SURF6 protein networkhttps://string-db.org/network/9606.ENSP00000361092Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembl [...]
TMEM69 protein networkhttps://string-db.org/network/9606.ENSP00000361095Transmembrane protein 69.
MMRN2 protein networkhttps://string-db.org/network/9606.ENSP00000361097Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.
BMPR1A protein networkhttps://string-db.org/network/9606.ENSP00000361107Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phospho [...]
GBGT1 protein networkhttps://string-db.org/network/9606.ENSP00000361110Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glyc [...]
CHRDL1 protein networkhttps://string-db.org/network/9606.ENSP00000361112Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurog [...]
RALGDS protein networkhttps://string-db.org/network/9606.ENSP00000361120Ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and [...]
TMEM164 protein networkhttps://string-db.org/network/9606.ENSP00000361138Transmembrane protein 164; Belongs to the TMEM164 family.
AKR1A1 protein networkhttps://string-db.org/network/9606.ENSP00000361140Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity tow [...]
OPN4 protein networkhttps://string-db.org/network/9606.ENSP00000361141Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all [...]
TESK2 protein networkhttps://string-db.org/network/9606.ENSP00000361158Dual specificity testis-specific protein kinase 2; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and [...]
CCSER2 protein networkhttps://string-db.org/network/9606.ENSP00000361160Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling.
TOE1 protein networkhttps://string-db.org/network/9606.ENSP00000361162Target of EGR1 protein 1; Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the matura [...]
KCNE5 protein networkhttps://string-db.org/network/9606.ENSP00000361173Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of [...]
LRIT1 protein networkhttps://string-db.org/network/9606.ENSP00000361177Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction.
GTF3C5 protein networkhttps://string-db.org/network/9606.ENSP00000361180General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...]
TP53RK protein networkhttps://string-db.org/network/9606.ENSP00000361186EKC/KEOPS complex subunit TP53RK; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codon [...]
C10orf99 protein networkhttps://string-db.org/network/9606.ENSP00000361199Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together w [...]
IRS4 protein networkhttps://string-db.org/network/9606.ENSP00000361202Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network o [...]
MRPS18A protein networkhttps://string-db.org/network/9606.ENSP00000361206Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily.
GHITM protein networkhttps://string-db.org/network/9606.ENSP00000361207Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c.
SPACA9 protein networkhttps://string-db.org/network/9606.ENSP00000361209Sperm acrosome associated 9.
NRG3 protein networkhttps://string-db.org/network/9606.ENSP00000361214Pro-neuregulin-3, membrane-bound isoform; Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does [...]
GTF3C4 protein networkhttps://string-db.org/network/9606.ENSP00000361219General transcription factor 3C polypeptide 4; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus- associated (VA) RNA [...]
TSPAN14 protein networkhttps://string-db.org/network/9606.ENSP00000361231Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cl [...]
DDX31 protein networkhttps://string-db.org/network/9606.ENSP00000361232Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 ; Bel [...]
RSPH9 protein networkhttps://string-db.org/network/9606.ENSP00000361238Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stal [...]
HECTD3 protein networkhttps://string-db.org/network/9606.ENSP00000361245E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targete [...]
RAPGEF1 protein networkhttps://string-db.org/network/9606.ENSP00000361264Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the estab [...]
PTCH2 protein networkhttps://string-db.org/network/9606.ENSP00000361266Protein patched homolog 2; Plays a role in the control of cellular growth. May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH); Belongs to the patched family.
DYDC2 protein networkhttps://string-db.org/network/9606.ENSP00000361272DPY30 domain containing 2; Belongs to the dpy-30 family.
PLK3 protein networkhttps://string-db.org/network/9606.ENSP00000361275Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphoryla [...]
DYDC1 protein networkhttps://string-db.org/network/9606.ENSP00000361278DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis.
BEST4 protein networkhttps://string-db.org/network/9606.ENSP00000361281Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
UCK1 protein networkhttps://string-db.org/network/9606.ENSP00000361285Uridine-cytidine kinase 1; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use [...]
MAT1A protein networkhttps://string-db.org/network/9606.ENSP00000361287S-adenosylmethionine synthase isoform type-1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: [...]
KIF2C protein networkhttps://string-db.org/network/9606.ENSP00000361298Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore [...]
POMT1 protein networkhttps://string-db.org/network/9606.ENSP00000361302Protein O-mannosyl-transferase 1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, express [...]
ATG4A protein networkhttps://string-db.org/network/9606.ENSP00000361306Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal gl [...]
POLH protein networkhttps://string-db.org/network/9606.ENSP00000361310DNA polymerase eta; DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetram [...]
TMEM53 protein networkhttps://string-db.org/network/9606.ENSP00000361311Transmembrane protein 53; Belongs to the TMEM53 family.
ERI3 protein networkhttps://string-db.org/network/9606.ENSP00000361331ERI1 exoribonuclease family member 3.
PLAC9 protein networkhttps://string-db.org/network/9606.ENSP00000361337Placenta-specific protein 9; Placenta associated 9; Belongs to the PLAC9 family.
PLPP7 protein networkhttps://string-db.org/network/9606.ENSP00000361338Inactive phospholipid phosphatase 7; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity [...]
FAM78A protein networkhttps://string-db.org/network/9606.ENSP00000361345Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family.
TMEM254 protein networkhttps://string-db.org/network/9606.ENSP00000361355Transmembrane protein 254.
CD40 protein networkhttps://string-db.org/network/9606.ENSP00000361359Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction o [...]
DMAP1 protein networkhttps://string-db.org/network/9606.ENSP00000361363DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin [...]
SFTPD protein networkhttps://string-db.org/network/9606.ENSP00000361366Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccha [...]
KLF17 protein networkhttps://string-db.org/network/9606.ENSP00000361373Krueppel-like factor 17; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and me [...]
AIF1L protein networkhttps://string-db.org/network/9606.ENSP00000361383Allograft inflammatory factor 1-like; Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.
CCDC24 protein networkhttps://string-db.org/network/9606.ENSP00000361392Coiled-coil domain containing 24.
NUTM2G protein networkhttps://string-db.org/network/9606.ENSP00000361397NUT family member 2G.
SFTPA2 protein networkhttps://string-db.org/network/9606.ENSP00000361400Surfactant protein A2.
MMP9 protein networkhttps://string-db.org/network/9606.ENSP0000036140567 kDa matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleav [...]
ZCCHC24 protein networkhttps://string-db.org/network/9606.ENSP00000361411Zinc finger CCHC-type containing 24.
FIBCD1 protein networkhttps://string-db.org/network/9606.ENSP00000361413Fibrinogen C domain-containing protein 1; Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carboh [...]
IPO13 protein networkhttps://string-db.org/network/9606.ENSP00000361418Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...]
ABL1 protein networkhttps://string-db.org/network/9606.ENSP00000361423Tyrosine-protein kinase ABL1; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extrac [...]
EXOSC2 protein networkhttps://string-db.org/network/9606.ENSP00000361433Exosome complex component RRP4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...]
POLR3A protein networkhttps://string-db.org/network/9606.ENSP00000361446DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catal [...]
TSC22D3 protein networkhttps://string-db.org/network/9606.ENSP00000361458TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apopt [...]
DLG5 protein networkhttps://string-db.org/network/9606.ENSP00000361467Disks large homolog 5; Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them togeth [...]
ASS1 protein networkhttps://string-db.org/network/9606.ENSP00000361471Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic [...]
KDM4A protein networkhttps://string-db.org/network/9606.ENSP00000361473Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylat [...]
NCS1 protein networkhttps://string-db.org/network/9606.ENSP00000361475Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Ca [...]
GPR107 protein networkhttps://string-db.org/network/9606.ENSP00000361483Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor. Involved in blood sugar regulation through the induction of glucag [...]
PCIF1 protein networkhttps://string-db.org/network/9606.ENSP00000361486mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at [...]
YIPF3 protein networkhttps://string-db.org/network/9606.ENSP00000361499Protein YIPF3, 36 kDa form III; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
HYI protein networkhttps://string-db.org/network/9606.ENSP00000361511Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
PRPS1 protein networkhttps://string-db.org/network/9606.ENSP00000361512Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase f [...]
LRRC73 protein networkhttps://string-db.org/network/9606.ENSP00000361518Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73.
TJAP1 protein networkhttps://string-db.org/network/9606.ENSP00000361522Tight junction associated protein 1.
C9orf78 protein networkhttps://string-db.org/network/9606.ENSP00000361524Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length. Belongs to the TLS1 family.
CDC20 protein networkhttps://string-db.org/network/9606.ENSP00000361540Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is r [...]
NUP62CL protein networkhttps://string-db.org/network/9606.ENSP00000361544Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family.
PRRX2 protein networkhttps://string-db.org/network/9606.ENSP00000361547Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development. Belongs to the paired homeobox family.
MPL protein networkhttps://string-db.org/network/9606.ENSP00000361548Thrombopoietin receptor; Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent [...]
TIE1 protein networkhttps://string-db.org/network/9606.ENSP00000361554Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
C9orf50 protein networkhttps://string-db.org/network/9606.ENSP00000361556Uncharacterized protein C9orf50; Chromosome 9 open reading frame 50.
RBM41 protein networkhttps://string-db.org/network/9606.ENSP00000361557RNA-binding protein 41; May bind RNA.
CTSA protein networkhttps://string-db.org/network/9606.ENSP00000361562Lysosomal protective protein 20 kDa chain; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a [...]
IER5L protein networkhttps://string-db.org/network/9606.ENSP00000361569Immediate early response 5 like.
ZNF691 protein networkhttps://string-db.org/network/9606.ENSP00000361580Zinc finger protein 691; May be involved in transcriptional regulation.
ERMAP protein networkhttps://string-db.org/network/9606.ENSP00000361595Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family.
NEURL2 protein networkhttps://string-db.org/network/9606.ENSP00000361596Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-bo [...]
SPATA25 protein networkhttps://string-db.org/network/9606.ENSP00000361597Spermatogenesis-associated protein 25; May play a role in spermatogenesis. Belongs to the SPATA25 family.
SVBP protein networkhttps://string-db.org/network/9606.ENSP00000361599Small vasohibin-binding protein; Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. This activi [...]
ZSWIM1 protein networkhttps://string-db.org/network/9606.ENSP00000361601Zinc finger SWIM-type containing 1.
ZNF503 protein networkhttps://string-db.org/network/9606.ENSP00000361602Zinc finger protein 503; May function as a transcriptional repressor.
C1orf50 protein networkhttps://string-db.org/network/9606.ENSP00000361603Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50.
ABCC10 protein networkhttps://string-db.org/network/9606.ENSP00000361608Multidrug resistance-associated protein 7; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.
COMTD1 protein networkhttps://string-db.org/network/9606.ENSP00000361616Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase [...]
DOLPP1 protein networkhttps://string-db.org/network/9606.ENSP00000361625Dolichyldiphosphatase 1; Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rat [...]
YBX1 protein networkhttps://string-db.org/network/9606.ENSP00000361626Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. P [...]
RADX protein networkhttps://string-db.org/network/9606.ENSP00000361628RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at fork [...]
SH3GLB2 protein networkhttps://string-db.org/network/9606.ENSP00000361634Endophilin-B2; SH3 domain containing GRB2 like, endophilin B2.
VDAC2 protein networkhttps://string-db.org/network/9606.ENSP00000361635Voltage-dependent anion-selective channel protein 2; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conf [...]
TNNC2 protein networkhttps://string-db.org/network/9606.ENSP00000361636Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T whi [...]
PPCS protein networkhttps://string-db.org/network/9606.ENSP00000361642Phosphopantothenate--cysteine ligase; Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothe [...]
ZMYND12 protein networkhttps://string-db.org/network/9606.ENSP00000361646Zinc finger MYND-type containing 12.
CRIP3 protein networkhttps://string-db.org/network/9606.ENSP00000361650Cysteine rich protein 3.
FOXJ3 protein networkhttps://string-db.org/network/9606.ENSP00000361653Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.
NUP188 protein networkhttps://string-db.org/network/9606.ENSP00000361658Nucleoporin NUP188 homolog; May function as a component of the nuclear pore complex (NPC).
GUCA2B protein networkhttps://string-db.org/network/9606.ENSP00000361662Guanylate cyclase C-activating peptide 2; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. [...]
IL1RAPL2 protein networkhttps://string-db.org/network/9606.ENSP00000361663Interleukin 1 receptor accessory protein like 2; Belongs to the interleukin-1 receptor family.
HIVEP3 protein networkhttps://string-db.org/network/9606.ENSP00000361664Transcription factor HIVEP3; Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segmen [...]
SLC22A7 protein networkhttps://string-db.org/network/9606.ENSP00000361666Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, g [...]
DOLK protein networkhttps://string-db.org/network/9606.ENSP00000361667Dolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.
EDN2 protein networkhttps://string-db.org/network/9606.ENSP00000361668Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides.
ESX1 protein networkhttps://string-db.org/network/9606.ENSP00000361669Homeobox protein ESX1-C; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby ar [...]
GLRA4 protein networkhttps://string-db.org/network/9606.ENSP00000361700Glycine receptor alpha 4.
DNTTIP1 protein networkhttps://string-db.org/network/9606.ENSP00000361705Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the conse [...]
TCEAL1 protein networkhttps://string-db.org/network/9606.ENSP00000361708Transcription elongation factor A protein-like 1; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example [...]
TCEAL3 protein networkhttps://string-db.org/network/9606.ENSP00000361711Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily.
TCEAL4 protein networkhttps://string-db.org/network/9606.ENSP00000361712Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation.
RAB40A protein networkhttps://string-db.org/network/9606.ENSP00000361716Ras-related protein Rab-40A; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...]
CITED4 protein networkhttps://string-db.org/network/9606.ENSP00000361721Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor [...]
ENDOG protein networkhttps://string-db.org/network/9606.ENSP00000361725Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single- stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNas [...]
WFDC10A protein networkhttps://string-db.org/network/9606.ENSP00000361726WAP four-disulfide core domain 10A.
BEX3 protein networkhttps://string-db.org/network/9606.ENSP00000361728Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role [...]
TBC1D13 protein networkhttps://string-db.org/network/9606.ENSP00000361731TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to [...]
WFDC8 protein networkhttps://string-db.org/network/9606.ENSP00000361735WAP four-disulfide core domain 8.
EPPIN protein networkhttps://string-db.org/network/9606.ENSP00000361746Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protect [...]
ZDHHC12 protein networkhttps://string-db.org/network/9606.ENSP00000361748Probable palmitoyltransferase ZDHHC12; Zinc finger DHHC-type palmitoyltransferase 12.
WFDC6 protein networkhttps://string-db.org/network/9606.ENSP00000361755WAP four-disulfide core domain 6.
WFDC2 protein networkhttps://string-db.org/network/9606.ENSP00000361761WAP four-disulfide core domain protein 2; Broad range protease inhibitor.
TCEAL5 protein networkhttps://string-db.org/network/9606.ENSP00000361765Transcription elongation factor A protein-like 5; May be involved in transcriptional regulation.
RIMS3 protein networkhttps://string-db.org/network/9606.ENSP00000361769Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis.
TCEAL8 protein networkhttps://string-db.org/network/9606.ENSP00000361770Transcription elongation factor A protein-like 8; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily.
SET protein networkhttps://string-db.org/network/9606.ENSP00000361777Protein SET; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activ [...]
BEX4 protein networkhttps://string-db.org/network/9606.ENSP00000361780Protein BEX4; May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progre [...]
EXO5 protein networkhttps://string-db.org/network/9606.ENSP00000361788Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (IC [...]
ZFP69 protein networkhttps://string-db.org/network/9606.ENSP00000361791Zinc finger protein 69 homolog; Putative transcription factor that appears to regulate lipid metabolism; Belongs to the krueppel C2H2-type zinc-finger protein family.
DBNDD2 protein networkhttps://string-db.org/network/9606.ENSP00000361795Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family.
WDR34 protein networkhttps://string-db.org/network/9606.ENSP00000361800WD repeat-containing protein 34; Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-b [...]
SMAP2 protein networkhttps://string-db.org/network/9606.ENSP00000361803Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endoso [...]
TP53TG5 protein networkhttps://string-db.org/network/9606.ENSP00000361811TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway.
BEX1 protein networkhttps://string-db.org/network/9606.ENSP00000361813Protein BEX1; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to n [...]
SDC4 protein networkhttps://string-db.org/network/9606.ENSP00000361818Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
COL9A2 protein networkhttps://string-db.org/network/9606.ENSP00000361834Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.
MATN4 protein networkhttps://string-db.org/network/9606.ENSP00000361842Matrilin-4; Major component of the extracellular matrix of cartilage.
ZMPSTE24 protein networkhttps://string-db.org/network/9606.ENSP00000361845CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.
PLAU protein networkhttps://string-db.org/network/9606.ENSP00000361850Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
TMCO2 protein networkhttps://string-db.org/network/9606.ENSP00000361852Transmembrane and coiled-coil domains 2.
SEMG2 protein networkhttps://string-db.org/network/9606.ENSP00000361855Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
RLF protein networkhttps://string-db.org/network/9606.ENSP00000361857Zinc finger protein Rlf; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TCEAL6 protein networkhttps://string-db.org/network/9606.ENSP00000361860Transcription elongation factor A like 6.
TCEAL2 protein networkhttps://string-db.org/network/9606.ENSP00000361866Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily.
SEMG1 protein networkhttps://string-db.org/network/9606.ENSP00000361867Seminal basic protein; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogeli [...]
ZMAT1 protein networkhttps://string-db.org/network/9606.ENSP00000361868Zinc finger matrin-type 1.
WFDC12 protein networkhttps://string-db.org/network/9606.ENSP00000361871WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.
WFDC5 protein networkhttps://string-db.org/network/9606.ENSP00000361875WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor.
CAP1 protein networkhttps://string-db.org/network/9606.ENSP00000361883Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization a [...]
STK4 protein networkhttps://string-db.org/network/9606.ENSP00000361892Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by intern [...]
GNMT protein networkhttps://string-db.org/network/9606.ENSP00000361894Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocyst [...]
MFSD2A protein networkhttps://string-db.org/network/9606.ENSP00000361895Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By si [...]
TOMM34 protein networkhttps://string-db.org/network/9606.ENSP00000361900Mitochondrial import receptor subunit TOM34; Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with [...]
OXCT2 protein networkhttps://string-db.org/network/9606.ENSP00000361914Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA interm [...]
BMP8B protein networkhttps://string-db.org/network/9606.ENSP00000361915Bone morphogenetic protein 8B; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...]
ARMCX1 protein networkhttps://string-db.org/network/9606.ENSP00000361917Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria i [...]
PPIE protein networkhttps://string-db.org/network/9606.ENSP00000361918Peptidyl-prolyl cis-trans isomerase E; Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-strand [...]
CHCHD1 protein networkhttps://string-db.org/network/9606.ENSP00000361923Coiled-coil-helix-coiled-coil-helix domain containing 1.
CNPY3 protein networkhttps://string-db.org/network/9606.ENSP00000361926Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticu [...]
HNRNPH2 protein networkhttps://string-db.org/network/9606.ENSP00000361927Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for th [...]
CERCAM protein networkhttps://string-db.org/network/9606.ENSP00000361929Inactive glycosyltransferase 25 family member 3; Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferas [...]
YWHAB protein networkhttps://string-db.org/network/9606.ENSP0000036193014-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of [...]
FUT11 protein networkhttps://string-db.org/network/9606.ENSP00000361932Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase.
HEYL protein networkhttps://string-db.org/network/9606.ENSP00000361943Hairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional represso [...]
PABPC4 protein networkhttps://string-db.org/network/9606.ENSP00000361949Polyadenylate-binding protein 4; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than [...]
KCNK15 protein networkhttps://string-db.org/network/9606.ENSP00000361952Potassium channel subfamily K member 15; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional [...]
CCN5 protein networkhttps://string-db.org/network/9606.ENSP00000361959CCN family member 5; May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, i [...]
ADA protein networkhttps://string-db.org/network/9606.ENSP00000361965Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by ext [...]
TBCC protein networkhttps://string-db.org/network/9606.ENSP00000361967Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family.
PKIG protein networkhttps://string-db.org/network/9606.ENSP00000361980cAMP-dependent protein kinase inhibitor gamma; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme af [...]
TRUB2 protein networkhttps://string-db.org/network/9606.ENSP00000361982Mitochondrial mRNA pseudouridine synthase TRUB2; Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as [...]
UBR2 protein networkhttps://string-db.org/network/9606.ENSP00000361990E3 ubiquitin-protein ligase UBR2; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are desta [...]
TIMM8A protein networkhttps://string-db.org/network/9606.ENSP00000361993Mitochondrial import inner membrane translocase subunit Tim8 A; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into [...]
TTPAL protein networkhttps://string-db.org/network/9606.ENSP00000361995Alpha-tocopherol transfer protein-like; May act as a protein that binds a hydrophobic ligand.
TAF7L protein networkhttps://string-db.org/network/9606.ENSP00000361998Transcription initiation factor TFIID subunit 7-like; Probably functions as a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protei [...]
ANXA7 protein networkhttps://string-db.org/network/9606.ENSP00000362010Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family.
DNM1 protein networkhttps://string-db.org/network/9606.ENSP00000362014Dynamin-1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. [...]
CENPI protein networkhttps://string-db.org/network/9606.ENSP00000362018Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
TMEM35A protein networkhttps://string-db.org/network/9606.ENSP00000362021Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.
TRMT2B protein networkhttps://string-db.org/network/9606.ENSP00000362027tRNA (uracil(54)-C(5))-methyltransferase homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. [...]
MRPS16 protein networkhttps://string-db.org/network/9606.ENSP00000362036Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.
DNAJC9 protein networkhttps://string-db.org/network/9606.ENSP00000362041DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8.
XKRX protein networkhttps://string-db.org/network/9606.ENSP00000362047XK-related protein 2; XK related X-linked.
GUCA1A-2 protein networkhttps://string-db.org/network/9606.ENSP00000362049Guanylate cyclase activator 1A.
NOX1 protein networkhttps://string-db.org/network/9606.ENSP00000362057NADPH oxidase 1; NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked [...]
NDUFS5 protein networkhttps://string-db.org/network/9606.ENSP00000362058NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in cat [...]
TAF8 protein networkhttps://string-db.org/network/9606.ENSP00000362068Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal [...]
JPH2 protein networkhttps://string-db.org/network/9606.ENSP00000362071Junctophilin-2 N-terminal fragment; [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for nor [...]
SYTL4 protein networkhttps://string-db.org/network/9606.ENSP00000362080Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phosph [...]
CCND3 protein networkhttps://string-db.org/network/9606.ENSP00000362082G1/S-specific cyclin-D3; Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...]
C9orf16 protein networkhttps://string-db.org/network/9606.ENSP00000362085UPF0184 protein C9orf16; Chromosome 9 open reading frame 16.
RRAGC protein networkhttps://string-db.org/network/9606.ENSP00000362092Ras-related GTP-binding protein C; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its sub [...]
GTSF1L protein networkhttps://string-db.org/network/9606.ENSP00000362094Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like.
SRPX2 protein networkhttps://string-db.org/network/9606.ENSP00000362095Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the forma [...]
POU3F1 protein networkhttps://string-db.org/network/9606.ENSP00000362103POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis.
UTP11 protein networkhttps://string-db.org/network/9606.ENSP00000362105Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.
FHL3 protein networkhttps://string-db.org/network/9606.ENSP00000362107Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.
LCN2 protein networkhttps://string-db.org/network/9606.ENSP00000362108Neutrophil gelatinase-associated lipocalin; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2 [...]
FRS3 protein networkhttps://string-db.org/network/9606.ENSP00000362109Fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 si [...]
SF3A3 protein networkhttps://string-db.org/network/9606.ENSP00000362110Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of [...]
TSPAN6 protein networkhttps://string-db.org/network/9606.ENSP00000362111Tetraspanin-6; Tetraspanin 6.
INPP5B protein networkhttps://string-db.org/network/9606.ENSP00000362115Type II inositol 1,4,5-trisphosphate 5-phosphatase; Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5- trisphosphate (PtIns(1,4 [...]
PGC protein networkhttps://string-db.org/network/9606.ENSP00000362116Gastricsin; Hydrolyzes a variety of proteins; Belongs to the peptidase A1 family.
IFT52 protein networkhttps://string-db.org/network/9606.ENSP00000362121Intraflagellar transport protein 52 homolog; Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the as [...]
TNMD protein networkhttps://string-db.org/network/9606.ENSP00000362122Tenomodulin; May be an angiogenesis inhibitor.
PLA2G12B protein networkhttps://string-db.org/network/9606.ENSP00000362123Group XIIB secretory phospholipase A2-like protein; Not known; does not seem to have catalytic activity.
PCDH19 protein networkhttps://string-db.org/network/9606.ENSP00000362125Protocadherin-19; Potential calcium-dependent cell-adhesion protein.
MTF1 protein networkhttps://string-db.org/network/9606.ENSP00000362127Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).
RPA4 protein networkhttps://string-db.org/network/9606.ENSP00000362131Replication protein A 30 kDa subunit; As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-conta [...]
C1orf122 protein networkhttps://string-db.org/network/9606.ENSP00000362133Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122.
YRDC protein networkhttps://string-db.org/network/9606.ENSP00000362135YrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters. Belongs to the SUA5 family.
MANEAL protein networkhttps://string-db.org/network/9606.ENSP00000362136Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family.
EPHA10 protein networkhttps://string-db.org/network/9606.ENSP00000362139Ephrin type-A receptor 10; Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5; Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subf [...]
MCU protein networkhttps://string-db.org/network/9606.ENSP00000362144Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subuni [...]
CDCA8 protein networkhttps://string-db.org/network/9606.ENSP00000362146Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct ch [...]
FOXP4 protein networkhttps://string-db.org/network/9606.ENSP00000362151Forkhead box protein P4; Transcriptional repressor that represses lung-specific expression.
GNL2 protein networkhttps://string-db.org/network/9606.ENSP00000362153Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell [...]
SLC25A25 protein networkhttps://string-db.org/network/9606.ENSP00000362160Calcium-binding mitochondrial carrier protein SCaMC-2; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mi [...]
MEAF6 protein networkhttps://string-db.org/network/9606.ENSP00000362166Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of [...]
NAIF1 protein networkhttps://string-db.org/network/9606.ENSP00000362170Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family.
NAP1L3 protein networkhttps://string-db.org/network/9606.ENSP00000362171Nucleosome assembly protein 1 like 3.
ZC3H12A protein networkhttps://string-db.org/network/9606.ENSP00000362179Endoribonuclease ZC3H12A; Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, [...]
NCR2 protein networkhttps://string-db.org/network/9606.ENSP00000362181Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.
GRIK3 protein networkhttps://string-db.org/network/9606.ENSP00000362183Glutamate receptor ionotropic, kainate 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transm [...]
PCDH11X protein networkhttps://string-db.org/network/9606.ENSP00000362186Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein.
FAM102A protein networkhttps://string-db.org/network/9606.ENSP00000362187Protein FAM102A; May play a role in estrogen action. Belongs to the FAM102 family.
CSF3R protein networkhttps://string-db.org/network/9606.ENSP00000362195Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differ [...]
TREM2 protein networkhttps://string-db.org/network/9606.ENSP00000362205Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyl [...]
KLHL4 protein networkhttps://string-db.org/network/9606.ENSP00000362206Kelch-like protein 4; Kelch like family member 4.
CHST3 protein networkhttps://string-db.org/network/9606.ENSP00000362207Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosa [...]
MRPS15 protein networkhttps://string-db.org/network/9606.ENSP00000362208Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family.
DACH2 protein networkhttps://string-db.org/network/9606.ENSP00000362217Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating prolifera [...]
STK40 protein networkhttps://string-db.org/network/9606.ENSP00000362222Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
ST6GALNAC6 protein networkhttps://string-db.org/network/9606.ENSP00000362235Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no ac [...]
POF1B protein networkhttps://string-db.org/network/9606.ENSP00000362238Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.
MAP7D1 protein networkhttps://string-db.org/network/9606.ENSP00000362244MAP7 domain containing 1; Belongs to the MAP7 family.
TSPO2 protein networkhttps://string-db.org/network/9606.ENSP00000362255Translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation.
APOOL protein networkhttps://string-db.org/network/9606.ENSP00000362268MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
HDX protein networkhttps://string-db.org/network/9606.ENSP00000362272Highly divergent homeobox.
ADPRHL2 protein networkhttps://string-db.org/network/9606.ENSP00000362273ADP-ribose glycohydrolase ARH3; ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different s [...]
SLC29A3 protein networkhttps://string-db.org/network/9606.ENSP00000362285Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as we [...]
AGO3 protein networkhttps://string-db.org/network/9606.ENSP00000362287Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Propos [...]
PTPRT protein networkhttps://string-db.org/network/9606.ENSP00000362294Receptor-type tyrosine-protein phosphatase T; May be involved in both signal transduction and cellular adhesion in the CNS; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B s [...]
SGPL1 protein networkhttps://string-db.org/network/9606.ENSP00000362298Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide pro [...]
ENG protein networkhttps://string-db.org/network/9606.ENSP00000362299Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migrati [...]
AGO1 protein networkhttps://string-db.org/network/9606.ENSP00000362300Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs whi [...]
ADAMTS14 protein networkhttps://string-db.org/network/9606.ENSP00000362304A disintegrin and metalloproteinase with thrombospondin motifs 14; Has aminoprocollagen type I processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requi [...]
AGO4 protein networkhttps://string-db.org/network/9606.ENSP00000362306Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks [...]
SH3BGRL protein networkhttps://string-db.org/network/9606.ENSP00000362308SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like.
EIF4EBP2 protein networkhttps://string-db.org/network/9606.ENSP00000362314Eukaryotic translation initiation factor 4E-binding protein 2; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E [...]
KCNK17 protein networkhttps://string-db.org/network/9606.ENSP00000362328Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
PPA1 protein networkhttps://string-db.org/network/9606.ENSP00000362329Inorganic pyrophosphatase 1.
CHD6 protein networkhttps://string-db.org/network/9606.ENSP00000362330Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner whic [...]
TFAP2E protein networkhttps://string-db.org/network/9606.ENSP00000362332Transcription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 facto [...]
PSMB2 protein networkhttps://string-db.org/network/9606.ENSP00000362334Proteasome subunit beta type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
SAR1A protein networkhttps://string-db.org/network/9606.ENSP00000362339GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER me [...]
NCDN protein networkhttps://string-db.org/network/9606.ENSP00000362340Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required [...]
FPGS protein networkhttps://string-db.org/network/9606.ENSP00000362344Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of [...]
MACROH2A2 protein networkhttps://string-db.org/network/9606.ENSP00000362352Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limitin [...]
GLP1R protein networkhttps://string-db.org/network/9606.ENSP00000362353Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP- 1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenyl [...]
CDK9 protein networkhttps://string-db.org/network/9606.ENSP00000362361Cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elong [...]
BRWD3 protein networkhttps://string-db.org/network/9606.ENSP00000362372Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
FAM241B protein networkhttps://string-db.org/network/9606.ENSP00000362376Protein FAM241B; May play a role in lysosome homeostasis. Belongs to the FAM241 family.
TOR2A protein networkhttps://string-db.org/network/9606.ENSP00000362381Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily.
TTC16 protein networkhttps://string-db.org/network/9606.ENSP00000362386Tetratricopeptide repeat domain 16.
TSPAN15 protein networkhttps://string-db.org/network/9606.ENSP00000362387Tetraspanin-15; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced No [...]
CFAP157 protein networkhttps://string-db.org/network/9606.ENSP00000362392Cilia- and flagella-associated protein 157; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary [...]
TBX22 protein networkhttps://string-db.org/network/9606.ENSP00000362393T-box transcription factor TBX22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.
ITM2A protein networkhttps://string-db.org/network/9606.ENSP00000362395Integral membrane protein 2A.
STXBP1 protein networkhttps://string-db.org/network/9606.ENSP00000362399Syntaxin-binding protein 1; Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission an [...]
CYSLTR1 protein networkhttps://string-db.org/network/9606.ENSP00000362401Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and prol [...]
TACR2 protein networkhttps://string-db.org/network/9606.ENSP00000362403Substance-K receptor; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger [...]
NIBAN2 protein networkhttps://string-db.org/network/9606.ENSP00000362409Protein Niban 2; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.
MAFB protein networkhttps://string-db.org/network/9606.ENSP00000362410Transcription factor MafB; Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythro [...]
PGK1 protein networkhttps://string-db.org/network/9606.ENSP00000362413Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition t [...]
TRAF3IP1 protein networkhttps://string-db.org/network/9606.ENSP00000362424TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-bind [...]
TMEM35B protein networkhttps://string-db.org/network/9606.ENSP00000362435Transmembrane protein 35B.
ATRX protein networkhttps://string-db.org/network/9606.ENSP00000362441Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replic [...]
ARHGAP40 protein networkhttps://string-db.org/network/9606.ENSP00000362442Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
DLGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000362444Disks large-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...]
ZNF79 protein networkhttps://string-db.org/network/9606.ENSP00000362446Zinc finger protein 79; May be involved in transcriptional regulation.
PBDC1 protein networkhttps://string-db.org/network/9606.ENSP00000362456Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family.
MAGEE2 protein networkhttps://string-db.org/network/9606.ENSP00000362457Melanoma-associated antigen E2; MAGE family member E2.
GLO1 protein networkhttps://string-db.org/network/9606.ENSP00000362463Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional [...]
GJB3 protein networkhttps://string-db.org/network/9606.ENSP00000362464Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
ZDHHC15 protein networkhttps://string-db.org/network/9606.ENSP00000362465Palmitoyltransferase ZDHHC15; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of GAP43 and DLG4/PSD95.
SLC2A8 protein networkhttps://string-db.org/network/9606.ENSP00000362469Solute carrier family 2, facilitated glucose transporter member 8; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the [...]
CSMD2 protein networkhttps://string-db.org/network/9606.ENSP00000362479CUB and Sushi multiple domains 2.
UPRT protein networkhttps://string-db.org/network/9606.ENSP00000362481Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family.
GARNL3 protein networkhttps://string-db.org/network/9606.ENSP00000362485GTPase-activating Rap/Ran-GAP domain-like protein 3; GTPase activating Rap/RanGAP domain like 3.
CCDC167 protein networkhttps://string-db.org/network/9606.ENSP00000362507Coiled-coil domain containing 167.
UGT1A4 protein networkhttps://string-db.org/network/9606.ENSP00000362508UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates [...]
UGT1A5 protein networkhttps://string-db.org/network/9606.ENSP00000362513UDP-glucuronosyltransferase 1-5; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...]
ANGPTL2 protein networkhttps://string-db.org/network/9606.ENSP00000362524Angiopoietin-related protein 2; Induces sprouting in endothelial cells through an autocrine and paracrine action.
UGT1A7 protein networkhttps://string-db.org/network/9606.ENSP00000362525UDP-glucuronosyltransferase 1-7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...]
RPRD1B protein networkhttps://string-db.org/network/9606.ENSP00000362532Regulation of nuclear pre-mRNA domain-containing protein 1B; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and partici [...]
AZIN2 protein networkhttps://string-db.org/network/9606.ENSP00000362540Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that cou [...]
TTI1 protein networkhttps://string-db.org/network/9606.ENSP00000362547TELO2-interacting protein 1 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related [...]
UGT1A8 protein networkhttps://string-db.org/network/9606.ENSP00000362549UDP-glucuronosyltransferase 1-8; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...]
CMTR1 protein networkhttps://string-db.org/network/9606.ENSP00000362550Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Met [...]
ZBTB34 protein networkhttps://string-db.org/network/9606.ENSP00000362551Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor.
RNF19B protein networkhttps://string-db.org/network/9606.ENSP00000362555E3 ubiquitin-protein ligase RNF19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transf [...]
VSTM2L protein networkhttps://string-db.org/network/9606.ENSP00000362560V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like.
TMEM54 protein networkhttps://string-db.org/network/9606.ENSP00000362562Transmembrane protein 54.
ZBTB43 protein networkhttps://string-db.org/network/9606.ENSP00000362563Zinc finger and BTB domain-containing protein 43; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HPCA protein networkhttps://string-db.org/network/9606.ENSP00000362566Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotid [...]
FNDC5 protein networkhttps://string-db.org/network/9606.ENSP00000362570Fibronectin type III domain-containing protein 5; [Irisin]: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white [...]
S100PBP protein networkhttps://string-db.org/network/9606.ENSP00000362574S100P binding protein.
YARS1 protein networkhttps://string-db.org/network/9606.ENSP00000362576Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then [...]
RNF8 protein networkhttps://string-db.org/network/9606.ENSP00000362578E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A a [...]
PBX3 protein networkhttps://string-db.org/network/9606.ENSP00000362588Pre-B-cell leukemia transcription factor 3; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'.
TBC1D22B protein networkhttps://string-db.org/network/9606.ENSP00000362590TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s).
RBBP4 protein networkhttps://string-db.org/network/9606.ENSP00000362592Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a mann [...]
CHIC1 protein networkhttps://string-db.org/network/9606.ENSP00000362601Cysteine-rich hydrophobic domain-containing protein 1; Cysteine rich hydrophobic domain 1; Belongs to the CHIC family.
PIM1 protein networkhttps://string-db.org/network/9606.ENSP00000362608Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigene [...]
ZBTB8A protein networkhttps://string-db.org/network/9606.ENSP00000362609Zinc finger and BTB domain-containing protein 8A; May be involved in transcriptional regulation.
CDX4 protein networkhttps://string-db.org/network/9606.ENSP00000362613Homeobox protein CDX-4; Caudal type homeobox 4; Belongs to the Caudal homeobox family.
NAP1L2 protein networkhttps://string-db.org/network/9606.ENSP00000362616Nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA; Belongs to the nucleosome assembly protein (NAP) family.
PABPC1L2A protein networkhttps://string-db.org/network/9606.ENSP00000362618poly(A) binding protein cytoplasmic 1 like 2A.
PABPC1L2B protein networkhttps://string-db.org/network/9606.ENSP00000362621poly(A) binding protein cytoplasmic 1 like 2B.
TSSK3 protein networkhttps://string-db.org/network/9606.ENSP00000362634Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function; Belongs to the protein kinase superfamily. CA [...]
MARCKSL1 protein networkhttps://string-db.org/network/9606.ENSP00000362638MARCKS-related protein; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration (By similarit [...]
RABEPK protein networkhttps://string-db.org/network/9606.ENSP00000362639Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
PHKA1 protein networkhttps://string-db.org/network/9606.ENSP00000362643Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha cha [...]
HDAC1 protein networkhttps://string-db.org/network/9606.ENSP00000362649Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
SCAI protein networkhttps://string-db.org/network/9606.ENSP00000362650Protein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration thro [...]
GOLGA1 protein networkhttps://string-db.org/network/9606.ENSP00000362656Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking.
HDAC8 protein networkhttps://string-db.org/network/9606.ENSP00000362674Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
SRC protein networkhttps://string-db.org/network/9606.ENSP00000362680Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response [...]
OLFML2A protein networkhttps://string-db.org/network/9606.ENSP00000362682Olfactomedin-like protein 2A; Olfactomedin like 2A.
FAM167B protein networkhttps://string-db.org/network/9606.ENSP00000362684Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family.
DDX50 protein networkhttps://string-db.org/network/9606.ENSP00000362687ATP-dependent RNA helicase DDX50; DExD-box helicase 50.
EIF3I protein networkhttps://string-db.org/network/9606.ENSP00000362688Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
NR5A1 protein networkhttps://string-db.org/network/9606.ENSP00000362690Steroidogenic factor 1; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of s [...]
NEK6 protein networkhttps://string-db.org/network/9606.ENSP00000362702Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust [...]
MANBAL protein networkhttps://string-db.org/network/9606.ENSP00000362707Protein MANBAL; Mannosidase beta like; Belongs to the UPF0239 family.
TXLNA protein networkhttps://string-db.org/network/9606.ENSP00000362711Alpha-taxilin; May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells; Belongs to the taxilin family.
GHRH protein networkhttps://string-db.org/network/9606.ENSP00000362716Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
LHX2 protein networkhttps://string-db.org/network/9606.ENSP00000362717LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differen [...]
DENND1A protein networkhttps://string-db.org/network/9606.ENSP00000362727DENN domain-containing protein 1A; Guanine nucleotide exchange factor (GEF) regulating clathrin- mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting ina [...]
KPNA6 protein networkhttps://string-db.org/network/9606.ENSP00000362728Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...]
MTCH1 protein networkhttps://string-db.org/network/9606.ENSP00000362730Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis.
CRB2 protein networkhttps://string-db.org/network/9606.ENSP00000362734Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move insid [...]
C2orf72 protein networkhttps://string-db.org/network/9606.ENSP00000362743Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72.
RPS4X protein networkhttps://string-db.org/network/9606.ENSP00000362744Ribosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family.
GPR21 protein networkhttps://string-db.org/network/9606.ENSP00000362746Probable G-protein coupled receptor 21; Orphan receptor.
TET1 protein networkhttps://string-db.org/network/9606.ENSP00000362748Methylcytosine dioxygenase TET1; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active D [...]
RABGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000362751Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in [...]
ADGRB2 protein networkhttps://string-db.org/network/9606.ENSP00000362759Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription facto [...]
ZBTB26 protein networkhttps://string-db.org/network/9606.ENSP00000362760Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation.
ZBTB6 protein networkhttps://string-db.org/network/9606.ENSP00000362763Zinc finger and BTB domain-containing protein 6; May be involved in transcriptional regulation.
RBL1 protein networkhttps://string-db.org/network/9606.ENSP00000362768Retinoblastoma-like protein 1; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of con [...]
RC3H2 protein networkhttps://string-db.org/network/9606.ENSP00000362774Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, [...]
COL16A1 protein networkhttps://string-db.org/network/9606.ENSP00000362776Collagen alpha-1(XVI) chain; Involved in mediating cell attachment and inducing integrin- mediated cellular reactions, such as cell spreading and alterations in cell morphology.
ATOH7 protein networkhttps://string-db.org/network/9606.ENSP00000362777Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells.
OR5C1 protein networkhttps://string-db.org/network/9606.ENSP00000362784Olfactory receptor 5C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CXCR3 protein networkhttps://string-db.org/network/9606.ENSP00000362795C-X-C chemokine receptor type 3; [Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells ( [...]
GCNA protein networkhttps://string-db.org/network/9606.ENSP00000362799Acidic repeat-containing protein; Germ cell nuclear acidic peptidase; Belongs to the serine-aspartate repeat-containing protein (SDr) family.
PPIL1 protein networkhttps://string-db.org/network/9606.ENSP00000362803Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of [...]
PEF1 protein networkhttps://string-db.org/network/9606.ENSP00000362807Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-d [...]
SERINC2 protein networkhttps://string-db.org/network/9606.ENSP00000362814Serine incorporator 2; Belongs to the TDE1 family.
FABP3 protein networkhttps://string-db.org/network/9606.ENSP00000362817Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters; Belongs to the calycin superfamily. Fatty-ac [...]
SRSF3 protein networkhttps://string-db.org/network/9606.ENSP00000362820Serine/arginine-rich splicing factor 3; Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and b [...]
OGT protein networkhttps://string-db.org/network/9606.ENSP00000362824UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytopl [...]
KCTD20 protein networkhttps://string-db.org/network/9606.ENSP00000362836BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members.
NKAIN1 protein networkhttps://string-db.org/network/9606.ENSP00000362841Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1.
REEP3 protein networkhttps://string-db.org/network/9606.ENSP00000362863Receptor expression-enhancing protein 3; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from ch [...]
MORN5 protein networkhttps://string-db.org/network/9606.ENSP00000362869MORN repeat containing 5.
MATN1 protein networkhttps://string-db.org/network/9606.ENSP00000362870Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
NDUFA8 protein networkhttps://string-db.org/network/9606.ENSP00000362873NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
ADO protein networkhttps://string-db.org/network/9606.ENSP000003628882-aminoethanethiol dioxygenase.
RTKN2 protein networkhttps://string-db.org/network/9606.ENSP00000362894Rhotekin-2; May play an important role in lymphopoiesis.
SRSF4 protein networkhttps://string-db.org/network/9606.ENSP00000362900Serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre- mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
GSN protein networkhttps://string-db.org/network/9606.ENSP00000362924Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote [...]
SRPK1 protein networkhttps://string-db.org/network/9606.ENSP00000362931SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, know [...]
ITGB1BP2 protein networkhttps://string-db.org/network/9606.ENSP00000362935Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells.
TRNAU1AP protein networkhttps://string-db.org/network/9606.ENSP00000362936tRNA selenocysteine 1-associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of [...]
PHACTR4 protein networkhttps://string-db.org/network/9606.ENSP00000362942Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. [...]
RAB14 protein networkhttps://string-db.org/network/9606.ENSP00000362946Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containi [...]
MED18 protein networkhttps://string-db.org/network/9606.ENSP00000362948Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
CNTRL protein networkhttps://string-db.org/network/9606.ENSP00000362962Centriolin; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediat [...]
CLPSL1 protein networkhttps://string-db.org/network/9606.ENSP00000362968Colipase-like protein 1; Colipase like 1; Belongs to the colipase family.
EYA3 protein networkhttps://string-db.org/network/9606.ENSP00000362978Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repai [...]
TGIF2 protein networkhttps://string-db.org/network/9606.ENSP00000362981Homeobox protein TGIF2; Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. [...]
PHYHIPL protein networkhttps://string-db.org/network/9606.ENSP00000362987Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system.
XKR8 protein networkhttps://string-db.org/network/9606.ENSP00000362991XK-related protein 8, processed form; Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only p [...]
BICC1 protein networkhttps://string-db.org/network/9606.ENSP00000362993Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
TRAF1 protein networkhttps://string-db.org/network/9606.ENSP00000362994TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by T [...]
SMPDL3B protein networkhttps://string-db.org/network/9606.ENSP00000363001Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition [...]
RPA2 protein networkhttps://string-db.org/network/9606.ENSP00000363017Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replicat [...]
RPL10A protein networkhttps://string-db.org/network/9606.ENSP0000036301860S ribosomal protein L10a; Component of the large ribosomal subunit.
UBE2D1 protein networkhttps://string-db.org/network/9606.ENSP00000363019Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates [...]
DLGAP4 protein networkhttps://string-db.org/network/9606.ENSP00000363023Disks large-associated protein 4; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...]
THEMIS2 protein networkhttps://string-db.org/network/9606.ENSP00000363031Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.
MEGF9 protein networkhttps://string-db.org/network/9606.ENSP00000363040Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9.
CISD1 protein networkhttps://string-db.org/network/9606.ENSP00000363041CDGSH iron-sulfur domain-containing protein 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluste [...]
AAR2 protein networkhttps://string-db.org/network/9606.ENSP00000363043Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family.
IPMK protein networkhttps://string-db.org/network/9606.ENSP00000363046Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphos [...]
STX12 protein networkhttps://string-db.org/network/9606.ENSP00000363054Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (i [...]
ZWINT protein networkhttps://string-db.org/network/9606.ENSP00000363055ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
ZNF76 protein networkhttps://string-db.org/network/9606.ENSP00000363064Zinc finger protein 76; May be involved in transcriptional regulation.
PCDH15 protein networkhttps://string-db.org/network/9606.ENSP00000363068Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
DES protein networkhttps://string-db.org/network/9606.ENSP00000363071Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the [...]
MBL2 protein networkhttps://string-db.org/network/9606.ENSP00000363079Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complemen [...]
DKK1 protein networkhttps://string-db.org/network/9606.ENSP00000363081Dickkopf-related protein 1; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...]
TLR4 protein networkhttps://string-db.org/network/9606.ENSP00000363089Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, [...]
PRKG1 protein networkhttps://string-db.org/network/9606.ENSP00000363092cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serin [...]
SCAND1 protein networkhttps://string-db.org/network/9606.ENSP00000363103SCAN domain-containing protein 1; May regulate transcriptional activity.
FGR protein networkhttps://string-db.org/network/9606.ENSP00000363117Tyrosine-protein kinase Fgr; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune response [...]
AHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000363123AT-hook DNA-binding motif-containing protein 1; AT-hook DNA binding motif containing 1.
PHF20 protein networkhttps://string-db.org/network/9606.ENSP00000363124PHD finger protein 20; Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16 [...]
ILRUN protein networkhttps://string-db.org/network/9606.ENSP00000363135Protein ILRUN; Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I [...]
GPR3 protein networkhttps://string-db.org/network/9606.ENSP00000363136G-protein coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavio [...]
CD164L2 protein networkhttps://string-db.org/network/9606.ENSP00000363142CD164 molecule like 2; Belongs to the CD164 family.
SPDEF protein networkhttps://string-db.org/network/9606.ENSP00000363149SAM pointed domain-containing Ets transcription factor; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. [...]
TNFSF15 protein networkhttps://string-db.org/network/9606.ENSP00000363157Tumor necrosis factor ligand superfamily member 15, membrane form; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in [...]
TMEM268 protein networkhttps://string-db.org/network/9606.ENSP00000363161Transmembrane protein 268.
ATP6V1G1 protein networkhttps://string-db.org/network/9606.ENSP00000363162V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...]
ROMO1 protein networkhttps://string-db.org/network/9606.ENSP00000363191Reactive oxygen species modulator 1; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicati [...]
MED12 protein networkhttps://string-db.org/network/9606.ENSP00000363193Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
NFS1 protein networkhttps://string-db.org/network/9606.ENSP00000363205Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. May be involved [...]
AGAP5 protein networkhttps://string-db.org/network/9606.ENSP00000363207Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.
TIMM23B protein networkhttps://string-db.org/network/9606.ENSP00000363211Translocase of inner mitochondrial membrane 23 homolog B.
OGDHL protein networkhttps://string-db.org/network/9606.ENSP000003632162-oxoglutarate dehydrogenase-like, mitochondrial; Oxoglutarate dehydrogenase L; Belongs to the alpha-ketoglutarate dehydrogenase family.
C10orf53 protein networkhttps://string-db.org/network/9606.ENSP00000363226UPF0728 protein C10orf53; Chromosome 10 open reading frame 53.
RBM12 protein networkhttps://string-db.org/network/9606.ENSP00000363228RNA binding motif protein 12.
SLC18A3 protein networkhttps://string-db.org/network/9606.ENSP00000363229Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles.
KIF12 protein networkhttps://string-db.org/network/9606.ENSP00000363232Kinesin-like protein KIF12; Kinesin family member 12; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
ZNF618 protein networkhttps://string-db.org/network/9606.ENSP00000363241Zinc finger protein 618; May be involved in transcriptional regulation.
GPN2 protein networkhttps://string-db.org/network/9606.ENSP00000363250GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-lo [...]
DRGX protein networkhttps://string-db.org/network/9606.ENSP00000363254Dorsal root ganglia homeobox protein; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perc [...]
RGS3 protein networkhttps://string-db.org/network/9606.ENSP00000363255Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-b [...]
ZDHHC18 protein networkhttps://string-db.org/network/9606.ENSP00000363257Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK.
C10orf71 protein networkhttps://string-db.org/network/9606.ENSP00000363259Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway.
PIGV protein networkhttps://string-db.org/network/9606.ENSP00000363260GPI mannosyltransferase 2; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI [...]
TMEM273 protein networkhttps://string-db.org/network/9606.ENSP00000363268Transmembrane protein 273.
RUFY4 protein networkhttps://string-db.org/network/9606.ENSP00000363270RUN and FYVE domain-containing protein 4; Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facil [...]
LRRC18 protein networkhttps://string-db.org/network/9606.ENSP00000363275Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation.
POLE3 protein networkhttps://string-db.org/network/9606.ENSP00000363286DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CH [...]
BSPRY protein networkhttps://string-db.org/network/9606.ENSP00000363298B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity.
WDR31 protein networkhttps://string-db.org/network/9606.ENSP00000363308WD repeat domain 31.
PRPF4 protein networkhttps://string-db.org/network/9606.ENSP00000363313U4/U6 small nuclear ribonucleoprotein Prp4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precat [...]
LIN28A protein networkhttps://string-db.org/network/9606.ENSP00000363314Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems [...]
FRMPD2 protein networkhttps://string-db.org/network/9606.ENSP00000363317FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2).
IL2RG protein networkhttps://string-db.org/network/9606.ENSP00000363318Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis [...]
CDC26 protein networkhttps://string-db.org/network/9606.ENSP00000363322Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and t [...]
SLC31A1 protein networkhttps://string-db.org/network/9606.ENSP00000363329High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake.
CD52 protein networkhttps://string-db.org/network/9606.ENSP00000363330CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
UBXN11 protein networkhttps://string-db.org/network/9606.ENSP00000363339UBX domain-containing protein 11; May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity) [...]
SLC46A2 protein networkhttps://string-db.org/network/9606.ENSP00000363345Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family.
SNX30 protein networkhttps://string-db.org/network/9606.ENSP00000363349Sorting nexin-30; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
INIP protein networkhttps://string-db.org/network/9606.ENSP00000363360SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates w [...]
CXorf65 protein networkhttps://string-db.org/network/9606.ENSP00000363369Uncharacterized protein CXorf65; Chromosome X open reading frame 65.
CNKSR1 protein networkhttps://string-db.org/network/9606.ENSP00000363371Connector enhancer of kinase suppressor of ras 1; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family.
FOXO4 protein networkhttps://string-db.org/network/9606.ENSP00000363377Forkhead box protein O4; Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down [...]
SUSD1 protein networkhttps://string-db.org/network/9606.ENSP00000363382Sushi domain containing 1.
ZNF593 protein networkhttps://string-db.org/network/9606.ENSP00000363384Zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting [...]
FAM110D protein networkhttps://string-db.org/network/9606.ENSP00000363386Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family.
PDIK1L protein networkhttps://string-db.org/network/9606.ENSP00000363389Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like.
TRIM63 protein networkhttps://string-db.org/network/9606.ENSP00000363390E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of musc [...]
SPAG4 protein networkhttps://string-db.org/network/9606.ENSP00000363391Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anch [...]
SLC30A2 protein networkhttps://string-db.org/network/9606.ENSP00000363394Zinc transporter 2; Solute carrier family 30 member 2; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
UGCG protein networkhttps://string-db.org/network/9606.ENSP00000363397Ceramide glucosyltransferase; Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from [...]
EXTL1 protein networkhttps://string-db.org/network/9606.ENSP00000363398Exostosin-like 1; Probable glycosyltransferase; Belongs to the glycosyltransferase 47 family.
PAFAH2 protein networkhttps://string-db.org/network/9606.ENSP00000363400Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the [...]
SHOC1 protein networkhttps://string-db.org/network/9606.ENSP00000363405Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates (By similarity). Binds DNA: preferentially binds to single-stra [...]
GNG10 protein networkhttps://string-db.org/network/9606.ENSP00000363411Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...]
DNAJC25-GNG10 protein networkhttps://string-db.org/network/9606.ENSP00000363412Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta a [...]
PAQR7 protein networkhttps://string-db.org/network/9606.ENSP00000363414Membrane progestin receptor alpha; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved i [...]
SLC7A3 protein networkhttps://string-db.org/network/9606.ENSP00000363417Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Belongs to the amino acid-polyamine-organocation [...]
MTFR1L protein networkhttps://string-db.org/network/9606.ENSP00000363419Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family.
NPY4R protein networkhttps://string-db.org/network/9606.ENSP00000363431Neuropeptide Y receptor Y4.
ITPR3 protein networkhttps://string-db.org/network/9606.ENSP00000363435Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
GPRIN2 protein networkhttps://string-db.org/network/9606.ENSP00000363436G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth.
SYT15 protein networkhttps://string-db.org/network/9606.ENSP00000363441Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
MAN1C1 protein networkhttps://string-db.org/network/9606.ENSP00000363452Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)Gl [...]
LDLRAP1 protein networkhttps://string-db.org/network/9606.ENSP00000363458Low density lipoprotein receptor adapter protein 1; Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells [...]
PTPN20 protein networkhttps://string-db.org/network/9606.ENSP00000363459Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase act [...]
MACO1 protein networkhttps://string-db.org/network/9606.ENSP00000363463Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.
TMEM50A protein networkhttps://string-db.org/network/9606.ENSP00000363478Transmembrane protein 50A; Belongs to the UPF0220 family.
DLG3 protein networkhttps://string-db.org/network/9606.ENSP00000363480Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.
GDF5 protein networkhttps://string-db.org/network/9606.ENSP00000363492Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstl [...]
CLIC4 protein networkhttps://string-db.org/network/9606.ENSP00000363500Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane inse [...]
UQCC1 protein networkhttps://string-db.org/network/9606.ENSP00000363506Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...]
ALOX5 protein networkhttps://string-db.org/network/9606.ENSP00000363512Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family.
NCMAP protein networkhttps://string-db.org/network/9606.ENSP00000363513Noncompact myelin-associated protein; Plays a role in myelin formation.
RCAN3 protein networkhttps://string-db.org/network/9606.ENSP00000363516Calcipressin-3; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By simil [...]
NIPAL3 protein networkhttps://string-db.org/network/9606.ENSP00000363520NIPA-like protein 3; NIPA like domain containing 3.
OR13A1 protein networkhttps://string-db.org/network/9606.ENSP00000363522Olfactory receptor 13A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
KIF4A protein networkhttps://string-db.org/network/9606.ENSP00000363524Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step f [...]
FAM83C protein networkhttps://string-db.org/network/9606.ENSP00000363529Protein FAM83C; May play a role in MAPK signaling. Belongs to the FAM83 family.
STPG1 protein networkhttps://string-db.org/network/9606.ENSP00000363530O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine.
MDH1B protein networkhttps://string-db.org/network/9606.ENSP00000363533Malate dehydrogenase 1B.
LPAR1 protein networkhttps://string-db.org/network/9606.ENSP00000363553Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and th [...]
MYOM3 protein networkhttps://string-db.org/network/9606.ENSP00000363557Myomesin-3; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle.
ZNF485 protein networkhttps://string-db.org/network/9606.ENSP00000363558Zinc finger protein 485; May be involved in transcriptional regulation.
EIF6 protein networkhttps://string-db.org/network/9606.ENSP00000363559Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Beh [...]
MUSK protein networkhttps://string-db.org/network/9606.ENSP00000363571Muscle, skeletal receptor tyrosine-protein kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse betwee [...]
RASGEF1A protein networkhttps://string-db.org/network/9606.ENSP00000363583Ras-GEF domain-containing family member 1A; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.
CSGALNACT2 protein networkhttps://string-db.org/network/9606.ENSP00000363590Chondroitin sulfate N-acetylgalactosaminyltransferase 2; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of [...]
BAK1 protein networkhttps://string-db.org/network/9606.ENSP00000363591Bcl-2 homologous antagonist/killer; Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligom [...]
SVEP1 protein networkhttps://string-db.org/network/9606.ENSP00000363593Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process.
CNR2 protein networkhttps://string-db.org/network/9606.ENSP00000363596Cannabinoid receptor 2; Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, noci [...]
RAB41 protein networkhttps://string-db.org/network/9606.ENSP00000363597Ras-related protein Rab-41; Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.
FUCA1 protein networkhttps://string-db.org/network/9606.ENSP00000363603Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoprote [...]
HMGCL protein networkhttps://string-db.org/network/9606.ENSP00000363614Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into ace [...]
EDEM2 protein networkhttps://string-db.org/network/9606.ENSP00000363616ER degradation-enhancing alpha-mannosidase-like protein 2; Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N [...]
TXNDC8 protein networkhttps://string-db.org/network/9606.ENSP00000363634Thioredoxin domain-containing protein 8; May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm.
LYPLA2 protein networkhttps://string-db.org/network/9606.ENSP00000363638Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoyla [...]
PHF1 protein networkhttps://string-db.org/network/9606.ENSP00000363640PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited [...]
TXN protein networkhttps://string-db.org/network/9606.ENSP00000363641Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role [...]
BMS1 protein networkhttps://string-db.org/network/9606.ENSP00000363642Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus.
P2RY4 protein networkhttps://string-db.org/network/9606.ENSP00000363643P2Y purinoceptor 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
AWAT1 protein networkhttps://string-db.org/network/9606.ENSP00000363645Acyl-CoA wax alcohol acyltransferase 1; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a strong preference fo [...]
PALM2AKAP2 protein networkhttps://string-db.org/network/9606.ENSP00000363654A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream [...]
IGBP1 protein networkhttps://string-db.org/network/9606.ENSP00000363661Immunoglobulin-binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP [...]
PTPN3 protein networkhttps://string-db.org/network/9606.ENSP00000363667Tyrosine-protein phosphatase non-receptor type 3; May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
EDA protein networkhttps://string-db.org/network/9606.ENSP00000363680Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain contain [...]
ID3 protein networkhttps://string-db.org/network/9606.ENSP00000363689DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...]
EPB41L4B protein networkhttps://string-db.org/network/9606.ENSP00000363694Band 4.1-like protein 4B; Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in ep [...]
BMPR2 protein networkhttps://string-db.org/network/9606.ENSP00000363708Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphor [...]
TMEM245 protein networkhttps://string-db.org/network/9606.ENSP00000363714Transmembrane protein 245; Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
STARD8 protein networkhttps://string-db.org/network/9606.ENSP00000363727StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1.
HNRNPR protein networkhttps://string-db.org/network/9606.ENSP00000363745Heterogeneous nuclear ribonucleoprotein R; Component of ribonucleosomes, which are complexes of at least 20 other different heterogeneous nuclear ribonucleoproteins (hnRNP). hnRNP play an importa [...]
WDR46 protein networkhttps://string-db.org/network/9606.ENSP00000363746WD repeat-containing protein 46; Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.
HTR1D protein networkhttps://string-db.org/network/9606.ENSP000003637485-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant [...]
ABITRAM protein networkhttps://string-db.org/network/9606.ENSP00000363753Protein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons.
C1QC protein networkhttps://string-db.org/network/9606.ENSP00000363770Complement C1q subcomponent subunit C; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...]
C1QA protein networkhttps://string-db.org/network/9606.ENSP00000363773Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...]
ELP1 protein networkhttps://string-db.org/network/9606.ENSP00000363779Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in trans [...]
RING1 protein networkhttps://string-db.org/network/9606.ENSP00000363787E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code [...]
HSD17B8 protein networkhttps://string-db.org/network/9606.ENSP00000363794Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with [...]
ACTL7B protein networkhttps://string-db.org/network/9606.ENSP00000363799Actin-like protein 7B; Actin like 7B; Belongs to the actin family.
KLF4 protein networkhttps://string-db.org/network/9606.ENSP00000363804Krueppel-like factor 4; Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its ow [...]
SLC39A7 protein networkhttps://string-db.org/network/9606.ENSP00000363809Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+ [...]
RXRB protein networkhttps://string-db.org/network/9606.ENSP00000363817Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retino [...]
AR protein networkhttps://string-db.org/network/9606.ENSP00000363822Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target ti [...]
TMEM38B protein networkhttps://string-db.org/network/9606.ENSP00000363824Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions [...]
FZD8 protein networkhttps://string-db.org/network/9606.ENSP00000363826Frizzled-8; Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-size [...]
HSPG2 protein networkhttps://string-db.org/network/9606.ENSP00000363827Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed nega [...]
AOX1 protein networkhttps://string-db.org/network/9606.ENSP00000363832Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as [...]
CCNY protein networkhttps://string-db.org/network/9606.ENSP00000363836Cyclin-Y; Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to [...]
COL11A2 protein networkhttps://string-db.org/network/9606.ENSP00000363840Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
SLC44A1 protein networkhttps://string-db.org/network/9606.ENSP00000363852Choline transporter-like protein 1; Choline transporter. May be involved in membrane synthesis and myelin production; Belongs to the CTL (choline transporter-like) family.
ABCA1 protein networkhttps://string-db.org/network/9606.ENSP00000363868Phospholipid-transporting ATPase ABCA1; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of AT [...]
VSIG4 protein networkhttps://string-db.org/network/9606.ENSP00000363869V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pat [...]
OXLD1 protein networkhttps://string-db.org/network/9606.ENSP00000363873Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1.
SLC38A10 protein networkhttps://string-db.org/network/9606.ENSP00000363891Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter.
NIPSNAP3B protein networkhttps://string-db.org/network/9606.ENSP00000363894Nipsnap homolog 3B; Belongs to the NipSnap family.
RAP1GAP protein networkhttps://string-db.org/network/9606.ENSP00000363895Rap1 GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state.
NIPSNAP3A protein networkhttps://string-db.org/network/9606.ENSP00000363899Nipsnap homolog 3A; Belongs to the NipSnap family.
OR13C5 protein networkhttps://string-db.org/network/9606.ENSP00000363911Olfactory receptor 13C5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR13C3 protein networkhttps://string-db.org/network/9606.ENSP00000363913Olfactory receptor 13C3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PARD3 protein networkhttps://string-db.org/network/9606.ENSP00000363921Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctio [...]
NCOA6 protein networkhttps://string-db.org/network/9606.ENSP00000363929Nuclear receptor coactivator 6; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Coactivates expre [...]
TP53INP2 protein networkhttps://string-db.org/network/9606.ENSP00000363943Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as [...]
LAS1L protein networkhttps://string-db.org/network/9606.ENSP00000363944Ribosomal biogenesis protein LAS1L; Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CH [...]
MAP1LC3A protein networkhttps://string-db.org/network/9606.ENSP00000363970Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the pha [...]
ZC4H2 protein networkhttps://string-db.org/network/9606.ENSP00000363972Zinc finger C4H2 domain-containing protein; Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation.
ALPL protein networkhttps://string-db.org/network/9606.ENSP00000363973Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi); Belongs to the alkaline phosphatase family.
HLA-DMA protein networkhttps://string-db.org/network/9606.ENSP00000363976HLA class II histocompatibility antigen, DM alpha chain; Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II [...]
PGAP4 protein networkhttps://string-db.org/network/9606.ENSP00000363984Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4.
MTMR8 protein networkhttps://string-db.org/network/9606.ENSP00000363985Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5- b [...]
PSMB9 protein networkhttps://string-db.org/network/9606.ENSP00000363993Proteasome subunit beta type-9; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the lea [...]
MRPL50 protein networkhttps://string-db.org/network/9606.ENSP00000363999Mitochondrial ribosomal protein L50.
COL5A2 protein networkhttps://string-db.org/network/9606.ENSP00000364000Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...]
AMER1 protein networkhttps://string-db.org/network/9606.ENSP00000364003APC membrane recruitment protein 1; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell [...]
PLPPR1 protein networkhttps://string-db.org/network/9606.ENSP00000364008Phospholipid phosphatase-related protein type 1; Phospholipid phosphatase related 1.
TMEFF1 protein networkhttps://string-db.org/network/9606.ENSP00000364013Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.
PSMB8 protein networkhttps://string-db.org/network/9606.ENSP00000364016Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the lea [...]
SPIN4 protein networkhttps://string-db.org/network/9606.ENSP00000364018Spindlin-4; Exhibits H3K4me3-binding activity. Belongs to the SPIN/STSY family.
ZXDB protein networkhttps://string-db.org/network/9606.ENSP00000364023Zinc finger X-linked protein ZXDB; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Belongs to the ZXD family.
ECE1 protein networkhttps://string-db.org/network/9606.ENSP00000364028Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1. Belongs to the peptidase M13 family.
TAP2 protein networkhttps://string-db.org/network/9606.ENSP00000364032Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold [...]
FAAH2 protein networkhttps://string-db.org/network/9606.ENSP00000364035Fatty-acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to termin [...]
TEX10 protein networkhttps://string-db.org/network/9606.ENSP00000364037Testis-expressed protein 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation [...]
SPIN2A protein networkhttps://string-db.org/network/9606.ENSP00000364043Spindlin-2A; May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity.
HLA-DQA2 protein networkhttps://string-db.org/network/9606.ENSP00000364076HLA class II histocompatibility antigen, DQ alpha 2 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell sur [...]
HLA-DQB1 protein networkhttps://string-db.org/network/9606.ENSP00000364080HLA class II histocompatibility antigen, DQ beta 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...]
PAGE3 protein networkhttps://string-db.org/network/9606.ENSP00000364089PAGE family member 3.
PAGE2 protein networkhttps://string-db.org/network/9606.ENSP00000364107PAGE family member 2.
PAGE2B protein networkhttps://string-db.org/network/9606.ENSP00000364110PAGE family member 2B; Belongs to the GAGE family.
HLA-DRB5 protein networkhttps://string-db.org/network/9606.ENSP00000364114HLA class II histocompatibility antigen, DR beta 5 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...]
MSANTD2 protein networkhttps://string-db.org/network/9606.ENSP00000364118Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2.
EIF2S2 protein networkhttps://string-db.org/network/9606.ENSP00000364119Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S [...]
APEX2 protein networkhttps://string-db.org/network/9606.ENSP00000364126DNA-(apurinic or apyrimidinic site) lyase 2; Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative [...]
COL15A1 protein networkhttps://string-db.org/network/9606.ENSP00000364140Collagen alpha-1(XV) chain; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.
PFKFB1 protein networkhttps://string-db.org/network/9606.ENSP000003641456-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family.
GALNT12 protein networkhttps://string-db.org/network/9606.ENSP00000364150Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
NOTCH4 protein networkhttps://string-db.org/network/9606.ENSP00000364163Neurogenic locus notch homolog protein 4; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...]
OR10G9 protein networkhttps://string-db.org/network/9606.ENSP00000364164Olfactory receptor 10G9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMEM225 protein networkhttps://string-db.org/network/9606.ENSP00000364166Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.
GPSM3 protein networkhttps://string-db.org/network/9606.ENSP00000364183G-protein-signaling modulator 3; Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins.
PBX2 protein networkhttps://string-db.org/network/9606.ENSP00000364190Pre-B-cell leukemia transcription factor 2; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1.
MAGED2 protein networkhttps://string-db.org/network/9606.ENSP00000364193Melanoma-associated antigen D2; Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt re [...]
PINK1 protein networkhttps://string-db.org/network/9606.ENSP00000364204Serine/threonine-protein kinase PINK1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of dam [...]
AGER protein networkhttps://string-db.org/network/9606.ENSP00000364210Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vasc [...]
CDA protein networkhttps://string-db.org/network/9606.ENSP00000364212Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
CAMK2N1 protein networkhttps://string-db.org/network/9606.ENSP00000364219Calcium/calmodulin-dependent protein kinase II inhibitor 1; Potent and specific inhibitor of CaM-kinase II (CAMK2). Belongs to the CAMK2N family.
VWA5B1 protein networkhttps://string-db.org/network/9606.ENSP00000364220Von Willebrand factor A domain containing 5B1.
RNF5 protein networkhttps://string-db.org/network/9606.ENSP00000364235E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiqui [...]
UBXN10 protein networkhttps://string-db.org/network/9606.ENSP00000364240UBX domain-containing protein 10; VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B ( [...]
PLA2G2F protein networkhttps://string-db.org/network/9606.ENSP00000364243Group IIF secretory phospholipase A2; May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By si [...]
PLA2G2D protein networkhttps://string-db.org/network/9606.ENSP00000364246Group IID secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is mo [...]
PLA2G5 protein networkhttps://string-db.org/network/9606.ENSP00000364249Calcium-dependent phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-o [...]
PLA2G2E protein networkhttps://string-db.org/network/9606.ENSP00000364257Group IIE secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic- containing phospholipids.
TRMO protein networkhttps://string-db.org/network/9606.ENSP00000364260tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoylade [...]
OTUD3 protein networkhttps://string-db.org/network/9606.ENSP00000364261OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains.
RNF186 protein networkhttps://string-db.org/network/9606.ENSP00000364263E3 ubiquitin-protein ligase RNF186; E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. In that process, stimulates the expressio [...]
FOXE1 protein networkhttps://string-db.org/network/9606.ENSP00000364265Forkhead box protein E1; Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably throug [...]
XPA protein networkhttps://string-db.org/network/9606.ENSP00000364270DNA repair protein complementing XP-A cells; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcrip [...]
FGD1 protein networkhttps://string-db.org/network/9606.ENSP00000364277FYVE, RhoGEF and PH domain-containing protein 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the ac [...]
NCBP1 protein networkhttps://string-db.org/network/9606.ENSP00000364289Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA [...]
TSR2 protein networkhttps://string-db.org/network/9606.ENSP00000364293Pre-rRNA-processing protein TSR2 homolog; May be involved in 20S pre-rRNA processing.
SLC66A1 protein networkhttps://string-db.org/network/9606.ENSP00000364295Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.
FKBPL protein networkhttps://string-db.org/network/9606.ENSP00000364298FK506-binding protein-like; May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
MRTO4 protein networkhttps://string-db.org/network/9606.ENSP00000364320mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolu [...]
FAM120C protein networkhttps://string-db.org/network/9606.ENSP00000364324Constitutive coactivator of PPAR-gamma-like protein 2; Family with sequence similarity 120C; Belongs to the constitutive coactivator of PPAR-gamma family.
ZNF341 protein networkhttps://string-db.org/network/9606.ENSP00000364346Zinc finger protein 341; Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription. Belongs to the krueppel C2H2-type zinc-fin [...]
ATF6B protein networkhttps://string-db.org/network/9606.ENSP00000364349Processed cyclic AMP-dependent transcription factor ATF-6 beta; Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER st [...]
MAP3K20 protein networkhttps://string-db.org/network/9606.ENSP00000364361Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that [...]
C20orf144 protein networkhttps://string-db.org/network/9606.ENSP00000364370Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144.
ZNF510 protein networkhttps://string-db.org/network/9606.ENSP00000364379Zinc finger protein 510; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PRXL2C protein networkhttps://string-db.org/network/9606.ENSP00000364382Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis. Belong [...]
CDC14B protein networkhttps://string-db.org/network/9606.ENSP00000364389Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates [...]
TMEM94 protein networkhttps://string-db.org/network/9606.ENSP00000364397Transmembrane protein 94.
HABP4 protein networkhttps://string-db.org/network/9606.ENSP00000364398Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding acti [...]
UBR4 protein networkhttps://string-db.org/network/9606.ENSP00000364403E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are desta [...]
DCAF17 protein networkhttps://string-db.org/network/9606.ENSP00000364404DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
ZNF367 protein networkhttps://string-db.org/network/9606.ENSP00000364405Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.
HSD17B3 protein networkhttps://string-db.org/network/9606.ENSP00000364412Testosterone 17-beta-dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH.
SP5 protein networkhttps://string-db.org/network/9606.ENSP00000364430Transcription factor Sp5; Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in [...]
UPF3A protein networkhttps://string-db.org/network/9606.ENSP00000364448Regulator of nonsense transcripts 3A; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving a [...]
SIK3 protein networkhttps://string-db.org/network/9606.ENSP00000364449Serine/threonine-protein kinase SIK3; Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR si [...]
AOPEP protein networkhttps://string-db.org/network/9606.ENSP00000364464Aminopeptidase O; Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a [...]
LYZL2 protein networkhttps://string-db.org/network/9606.ENSP00000364467Lysozyme-like protein 2; Lysozyme like 2.
RIBC1 protein networkhttps://string-db.org/network/9606.ENSP00000364476RIB43A domain with coiled-coils 1; Belongs to the RIB43A family.
STK19 protein networkhttps://string-db.org/network/9606.ENSP00000364482Serine/threonine-protein kinase 19; Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding [...]
FBP2 protein networkhttps://string-db.org/network/9606.ENSP00000364486Fructose-1,6-bisphosphatase isozyme 2; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synt [...]
ALDH4A1 protein networkhttps://string-db.org/network/9606.ENSP00000364490Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a n [...]
MFSD14B protein networkhttps://string-db.org/network/9606.ENSP00000364493Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain containing 14B.
DXO protein networkhttps://string-db.org/network/9606.ENSP00000364498Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphoh [...]
CD300LD protein networkhttps://string-db.org/network/9606.ENSP00000364501CMRF35-like molecule 5; CD300 molecule like family member d.
TMEM255B protein networkhttps://string-db.org/network/9606.ENSP00000364502Transmembrane protein 255B.
G6PC2 protein networkhttps://string-db.org/network/9606.ENSP00000364512Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By simila [...]
BTBD17 protein networkhttps://string-db.org/network/9606.ENSP00000364515BTB/POZ domain-containing protein 17; BTB domain containing 17.
TFDP1 protein networkhttps://string-db.org/network/9606.ENSP00000364519Transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter reg [...]
TAS1R2 protein networkhttps://string-db.org/network/9606.ENSP00000364520Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
PAX7 protein networkhttps://string-db.org/network/9606.ENSP00000364524Paired box protein Pax-7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation.
JCAD protein networkhttps://string-db.org/network/9606.ENSP00000364526Junctional protein associated with coronary artery disease; Junctional cadherin 5 associated.
SKIV2L protein networkhttps://string-db.org/network/9606.ENSP00000364543Helicase SKI2W; Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a m [...]
KDM5C protein networkhttps://string-db.org/network/9606.ENSP00000364550Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', [...]
ACTL8 protein networkhttps://string-db.org/network/9606.ENSP00000364555Actin-like protein 8; Actin like 8.
FAM120AOS protein networkhttps://string-db.org/network/9606.ENSP00000364561Uncharacterized protein FAM120AOS; Family with sequence similarity 120A opposite strand.
ADPRHL1 protein networkhttps://string-db.org/network/9606.ENSP00000364567[Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1.
C9orf129 protein networkhttps://string-db.org/network/9606.ENSP00000364568Putative uncharacterized protein C9orf129; Chromosome 9 open reading frame 129.
NELFE protein networkhttps://string-db.org/network/9606.ENSP00000364578Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...]
GRTP1 protein networkhttps://string-db.org/network/9606.ENSP00000364579Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s).
RCC2 protein networkhttps://string-db.org/network/9606.ENSP00000364585Protein RCC2; Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both d [...]
CUL4A protein networkhttps://string-db.org/network/9606.ENSP00000364589Cullin-4A; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalys [...]
TSPYL2 protein networkhttps://string-db.org/network/9606.ENSP00000364591Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating [...]
NINJ1 protein networkhttps://string-db.org/network/9606.ENSP00000364595Ninjurin-1; Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalen [...]
PADI4 protein networkhttps://string-db.org/network/9606.ENSP00000364597Protein-arginine deiminase type-4; Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem ce [...]
BPIFA3 protein networkhttps://string-db.org/network/9606.ENSP00000364603BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
PADI3 protein networkhttps://string-db.org/network/9606.ENSP00000364609Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins.
CARD19 protein networkhttps://string-db.org/network/9606.ENSP00000364613Caspase recruitment domain-containing protein 19; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent ma [...]
PADI1 protein networkhttps://string-db.org/network/9606.ENSP00000364620Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family.
SUSD3 protein networkhttps://string-db.org/network/9606.ENSP00000364621Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration.
NXPE4 protein networkhttps://string-db.org/network/9606.ENSP00000364627NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family.
BPIFB4 protein networkhttps://string-db.org/network/9606.ENSP00000364632BPI fold-containing family B member 4; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to acc [...]
PADI2 protein networkhttps://string-db.org/network/9606.ENSP00000364635Protein-arginine deiminase type-2; Catalyzes the deimination of arginine residues of proteins.
RBM7 protein networkhttps://string-db.org/network/9606.ENSP00000364639RNA-binding protein 7; RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short- [...]
BPIFB3 protein networkhttps://string-db.org/network/9606.ENSP00000364643BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to acc [...]
SDHB protein networkhttps://string-db.org/network/9606.ENSP00000364649Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial elec [...]
LYZL1 protein networkhttps://string-db.org/network/9606.ENSP00000364650Lysozyme-like protein 1; Lysozyme like 1; Belongs to the glycosyl hydrolase 22 family.
SPANXN5 protein networkhttps://string-db.org/network/9606.ENSP00000364661Sperm protein associated with the nucleus on the X chromosome N5; SPANX family member N5; Belongs to the SPAN-X family.
ZBTB12 protein networkhttps://string-db.org/network/9606.ENSP00000364677Zinc finger and BTB domain-containing protein 12; May be involved in transcriptional regulation.
BAMBI protein networkhttps://string-db.org/network/9606.ENSP00000364683BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family.
MFAP2 protein networkhttps://string-db.org/network/9606.ENSP00000364685Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family.
CROCC protein networkhttps://string-db.org/network/9606.ENSP00000364691Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends prox [...]
ASPN protein networkhttps://string-db.org/network/9606.ENSP00000364694Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhi [...]
SDHD protein networkhttps://string-db.org/network/9606.ENSP00000364699Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial ele [...]
OMD protein networkhttps://string-db.org/network/9606.ENSP00000364700Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity).
F10 protein networkhttps://string-db.org/network/9606.ENSP00000364709Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting [...]
OGN protein networkhttps://string-db.org/network/9606.ENSP00000364711Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.
MAPRE1 protein networkhttps://string-db.org/network/9606.ENSP00000364721Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promo [...]
F7 protein networkhttps://string-db.org/network/9606.ENSP00000364731Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, [...]
CENPP protein networkhttps://string-db.org/network/9606.ENSP00000364737Centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
FBXO42 protein networkhttps://string-db.org/network/9606.ENSP00000364742F-box only protein 42; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and d [...]
CPLANE2 protein networkhttps://string-db.org/network/9606.ENSP00000364749Ciliogenesis and planar polarity effector 2; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle [...]
XAGE1A protein networkhttps://string-db.org/network/9606.ENSP00000364752X antigen family member 1A.
LAYN protein networkhttps://string-db.org/network/9606.ENSP00000364765Layilin; Receptor for hyaluronate.
XAGE1B protein networkhttps://string-db.org/network/9606.ENSP00000364766X antigen family member 1B.
NEU1 protein networkhttps://string-db.org/network/9606.ENSP00000364782Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme [...]
IARS1 protein networkhttps://string-db.org/network/9606.ENSP00000364794Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...]
HSPA1B protein networkhttps://string-db.org/network/9606.ENSP00000364801Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized [...]
HSPA1A protein networkhttps://string-db.org/network/9606.ENSP00000364802Heat shock protein family A member 1A.
HSPA1L protein networkhttps://string-db.org/network/9606.ENSP00000364805Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesi [...]
LSM2 protein networkhttps://string-db.org/network/9606.ENSP00000364813U6 snRNA-associated Sm-like protein LSm2; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
FAM131C protein networkhttps://string-db.org/network/9606.ENSP00000364814Protein FAM131C; Family with sequence similarity 131 member C.
VARS1 protein networkhttps://string-db.org/network/9606.ENSP00000364815Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family.
CLCNKB protein networkhttps://string-db.org/network/9606.ENSP00000364831Chloride channel protein ClC-Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transdu [...]
ASXL1 protein networkhttps://string-db.org/network/9606.ENSP00000364839Polycomb group protein ASXL1; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RAR [...]
VWA7 protein networkhttps://string-db.org/network/9606.ENSP00000364840Von Willebrand factor A domain containing 7.
MAGED1 protein networkhttps://string-db.org/network/9606.ENSP00000364847Melanoma-associated antigen D1; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apopto [...]
MSH5 protein networkhttps://string-db.org/network/9606.ENSP00000364855MutS protein homolog 5; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity); Belongs to the DNA mismatch re [...]
CARD16 protein networkhttps://string-db.org/network/9606.ENSP00000364858Caspase recruitment domain-containing protein 16; Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interle [...]
CARD17 protein networkhttps://string-db.org/network/9606.ENSP00000364859Caspase recruitment domain-containing protein 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during [...]
ROR2 protein networkhttps://string-db.org/network/9606.ENSP00000364860Tyrosine-protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and g [...]
KIF3B protein networkhttps://string-db.org/network/9606.ENSP00000364864Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous [...]
HSPB7 protein networkhttps://string-db.org/network/9606.ENSP00000364870Heat shock protein family B member 7; Belongs to the small heat shock protein (HSP20) family.
AUH protein networkhttps://string-db.org/network/9606.ENSP00000364883Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itacon [...]
ZBTB17 protein networkhttps://string-db.org/network/9606.ENSP00000364885Zinc finger and BTB domain-containing protein 17; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of ce [...]
RND3 protein networkhttps://string-db.org/network/9606.ENSP00000364886Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.
SYK protein networkhttps://string-db.org/network/9606.ENSP00000364898Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell [...]
POFUT1 protein networkhttps://string-db.org/network/9606.ENSP00000364902GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence [...]
SPEN protein networkhttps://string-db.org/network/9606.ENSP00000364912Msx2-interacting protein; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 [...]
DIRAS2 protein networkhttps://string-db.org/network/9606.ENSP00000364919GTP-binding protein Di-Ras2; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family.
ING1 protein networkhttps://string-db.org/network/9606.ENSP00000364929Inhibitor of growth protein 1; Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor [...]
CLIC1 protein networkhttps://string-db.org/network/9606.ENSP00000364935Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occu [...]
TMEM82 protein networkhttps://string-db.org/network/9606.ENSP00000364938Transmembrane protein 82.
MKX protein networkhttps://string-db.org/network/9606.ENSP00000364946Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion. Belongs to the TALE/IRO homeobox family.
DDAH2 protein networkhttps://string-db.org/network/9606.ENSP00000364949N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in [...]
PLEKHM2 protein networkhttps://string-db.org/network/9606.ENSP00000364956Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play [...]
SECISBP2 protein networkhttps://string-db.org/network/9606.ENSP00000364965Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
CKS2 protein networkhttps://string-db.org/network/9606.ENSP00000364976Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
LY6G6C protein networkhttps://string-db.org/network/9606.ENSP00000364978Lymphocyte antigen 6 family member G6C.
COL4A1 protein networkhttps://string-db.org/network/9606.ENSP00000364979Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
LY6G6D protein networkhttps://string-db.org/network/9606.ENSP00000364985Lymphocyte antigen 6 family member G6D.
AGMAT protein networkhttps://string-db.org/network/9606.ENSP00000364986Agmatinase, mitochondrial; Agmatinase.
LY6G6F protein networkhttps://string-db.org/network/9606.ENSP00000364992Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7.
SHC3 protein networkhttps://string-db.org/network/9606.ENSP00000364995SHC-transforming protein 3; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activate [...]
S1PR3 protein networkhttps://string-db.org/network/9606.ENSP00000365006Sphingosine 1-phosphate receptor 3; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of [...]
DNAJC16 protein networkhttps://string-db.org/network/9606.ENSP00000365007DnaJ heat shock protein family member C16.
HCK protein networkhttps://string-db.org/network/9606.ENSP00000365012Tyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of [...]
NXNL2 protein networkhttps://string-db.org/network/9606.ENSP00000365014Nucleoredoxin-like protein 2; May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons; Belongs to the nucleore [...]
IRS2 protein networkhttps://string-db.org/network/9606.ENSP00000365016Insulin receptor substrate 2; May mediate the control of various cellular processes by insulin.
SPIN1 protein networkhttps://string-db.org/network/9606.ENSP00000365019Spindlin-1; Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activ [...]
LY6G5B protein networkhttps://string-db.org/network/9606.ENSP00000365024Lymphocyte antigen 6 family member G5B.
CSNK2B protein networkhttps://string-db.org/network/9606.ENSP00000365042Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 [...]
TNFSF13B protein networkhttps://string-db.org/network/9606.ENSP00000365048Tumor necrosis factor ligand superfamily member 13b, membrane form; Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 l [...]
ACBD5 protein networkhttps://string-db.org/network/9606.ENSP00000365049Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medi [...]
ABHD13 protein networkhttps://string-db.org/network/9606.ENSP00000365063Protein ABHD13; Abhydrolase domain containing 13.
GPANK1 protein networkhttps://string-db.org/network/9606.ENSP00000365071G-patch domain and ankyrin repeats 1.
CELA2B protein networkhttps://string-db.org/network/9606.ENSP00000365075Chymotrypsin-like elastase family member 2B; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily.
C6orf47 protein networkhttps://string-db.org/network/9606.ENSP00000365076Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47.
FAM155A protein networkhttps://string-db.org/network/9606.ENSP00000365080Transmembrane protein FAM155A; Family with sequence similarity 155 member A.
APOM protein networkhttps://string-db.org/network/9606.ENSP00000365081Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid [...]
MASTL protein networkhttps://string-db.org/network/9606.ENSP00000365107Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation o [...]
CTRC protein networkhttps://string-db.org/network/9606.ENSP00000365116Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease [...]
TUT7 protein networkhttps://string-db.org/network/9606.ENSP00000365130Terminal uridylyltransferase 7; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Esse [...]
BAG6 protein networkhttps://string-db.org/network/9606.ENSP00000365131Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein [...]
FOXS1 protein networkhttps://string-db.org/network/9606.ENSP00000365145Forkhead box protein S1; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By s [...]
EFHD2 protein networkhttps://string-db.org/network/9606.ENSP00000365147EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating b [...]
ISCA1 protein networkhttps://string-db.org/network/9606.ENSP00000365159Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved [...]
NUDT11 protein networkhttps://string-db.org/network/9606.ENSP00000365160Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a rol [...]
MYLK2 protein networkhttps://string-db.org/network/9606.ENSP00000365162Myosin light chain kinase 2, skeletal/cardiac muscle; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin lig [...]
POGLUT2 protein networkhttps://string-db.org/network/9606.ENSP00000365172Protein O-glucosyltransferase 2; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. [...]
NUDT10 protein networkhttps://string-db.org/network/9606.ENSP00000365174Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a ro [...]
TMEM51 protein networkhttps://string-db.org/network/9606.ENSP00000365176Transmembrane protein 51.
SHROOM4 protein networkhttps://string-db.org/network/9606.ENSP00000365188Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distrib [...]
KAZN protein networkhttps://string-db.org/network/9606.ENSP00000365198Kazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
TEX30 protein networkhttps://string-db.org/network/9606.ENSP00000365200Testis-expressed protein 30; Testis expressed 30.
PRRC2A protein networkhttps://string-db.org/network/9606.ENSP00000365201Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing.
CCNB3 protein networkhttps://string-db.org/network/9606.ENSP00000365210G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via t [...]
TPP2 protein networkhttps://string-db.org/network/9606.ENSP00000365220Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to [...]
AIF1 protein networkhttps://string-db.org/network/9606.ENSP00000365227Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signali [...]
BCL2L1 protein networkhttps://string-db.org/network/9606.ENSP00000365230Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and [...]
COX4I2 protein networkhttps://string-db.org/network/9606.ENSP00000365243Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylatio [...]
LRRC38 protein networkhttps://string-db.org/network/9606.ENSP00000365253Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...]
ANKRD26 protein networkhttps://string-db.org/network/9606.ENSP00000365255Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
CLCN5 protein networkhttps://string-db.org/network/9606.ENSP00000365256H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosom [...]
LST1 protein networkhttps://string-db.org/network/9606.ENSP00000365261Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a vari [...]
PRAMEF17 protein networkhttps://string-db.org/network/9606.ENSP00000365266PRAME family member 17; Belongs to the PRAME family.
PRAMEF19 protein networkhttps://string-db.org/network/9606.ENSP00000365269PRAME family member 19; Belongs to the PRAME family.
DLG2 protein networkhttps://string-db.org/network/9606.ENSP00000365272Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts [...]
ID1 protein networkhttps://string-db.org/network/9606.ENSP00000365280DNA-binding protein inhibitor ID-1; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...]
FAM181B protein networkhttps://string-db.org/network/9606.ENSP00000365295Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family.
FGF14 protein networkhttps://string-db.org/network/9606.ENSP00000365301Fibroblast growth factor 14; Probably involved in nervous system development and function.
ABI1 protein networkhttps://string-db.org/network/9606.ENSP00000365312Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced [...]
NFKBIL1 protein networkhttps://string-db.org/network/9606.ENSP00000365318NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathwa [...]
PAGE1 protein networkhttps://string-db.org/network/9606.ENSP00000365320PAGE family member 1.
PRAMEF15 protein networkhttps://string-db.org/network/9606.ENSP00000365322PRAME family member 15; Belongs to the PRAME family.
ITGBL1 protein networkhttps://string-db.org/network/9606.ENSP00000365351Integrin subunit beta like 1.
PRAMEF6 protein networkhttps://string-db.org/network/9606.ENSP00000365360PRAME family member 6; Belongs to the PRAME family.
MCCD1 protein networkhttps://string-db.org/network/9606.ENSP00000365362Mitochondrial coiled-coil domain 1.
HNRNPCL1 protein networkhttps://string-db.org/network/9606.ENSP00000365370Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.
FOXP3 protein networkhttps://string-db.org/network/9606.ENSP00000365380Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in ma [...]
PDSS1 protein networkhttps://string-db.org/network/9606.ENSP00000365388Decaprenyl-diphosphate synthase subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. Belongs to the FPP/GGPP synthase family.
AADACL4 protein networkhttps://string-db.org/network/9606.ENSP00000365395Arylacetamide deacetylase like 4.
CCDC22 protein networkhttps://string-db.org/network/9606.ENSP00000365401Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation lead [...]
HLA-C protein networkhttps://string-db.org/network/9606.ENSP00000365402HLA class I histocompatibility antigen, C alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity. I [...]
ZNF549 protein networkhttps://string-db.org/network/9606.ENSP00000365407Zinc finger protein 549; May be involved in transcriptional regulation.
APBB1IP protein networkhttps://string-db.org/network/9606.ENSP00000365411Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses in [...]
SLC28A3 protein networkhttps://string-db.org/network/9606.ENSP00000365413Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleos [...]
GGACT protein networkhttps://string-db.org/network/9606.ENSP00000365426Gamma-glutamylaminecyclotransferase; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes t [...]
TCF19 protein networkhttps://string-db.org/network/9606.ENSP00000365433Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
TNFRSF1B protein networkhttps://string-db.org/network/9606.ENSP00000365435Tumor necrosis factor receptor superfamily member 1b, membrane form; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-a [...]
GAD2 protein networkhttps://string-db.org/network/9606.ENSP00000365437Glutamate decarboxylase 2; Catalyzes the production of GABA.
CACNA1F protein networkhttps://string-db.org/network/9606.ENSP00000365441Voltage-dependent L-type calcium channel subunit alpha-1F; [Isoform 1]: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a [...]
HNRNPK protein networkhttps://string-db.org/network/9606.ENSP00000365458Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particula [...]
PCCA protein networkhttps://string-db.org/network/9606.ENSP00000365462Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of o [...]
CDSN protein networkhttps://string-db.org/network/9606.ENSP00000365465Corneodesmosin; Important for the epidermal barrier integrity.
MUC21 protein networkhttps://string-db.org/network/9606.ENSP00000365473Mucin-21; Mucin 21, cell surface associated.
CCDC93 protein networkhttps://string-db.org/network/9606.ENSP00000365477Coiled-coil domain-containing protein 93; Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and [...]
DEFB123 protein networkhttps://string-db.org/network/9606.ENSP00000365486Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family.
DEFB119 protein networkhttps://string-db.org/network/9606.ENSP00000365492Defensin beta 119.
SHISA7 protein networkhttps://string-db.org/network/9606.ENSP00000365503Protein shisa-7; Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory [...]
PLP2 protein networkhttps://string-db.org/network/9606.ENSP00000365505Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium.
ZIC2 protein networkhttps://string-db.org/network/9606.ENSP00000365514Zinc finger protein ZIC 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin tra [...]
C9orf64 protein networkhttps://string-db.org/network/9606.ENSP00000365522Queuosine salvage protein; Involved in salvaging queuosine.
PTPRH protein networkhttps://string-db.org/network/9606.ENSP00000365528Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associ [...]
GPR158 protein networkhttps://string-db.org/network/9606.ENSP00000365529Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family.
STXBP4 protein networkhttps://string-db.org/network/9606.ENSP00000365530Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to [...]
CLYBL protein networkhttps://string-db.org/network/9606.ENSP00000365533Citramalyl-CoA lyase, mitochondrial; Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxy [...]
GKAP1 protein networkhttps://string-db.org/network/9606.ENSP00000365550G kinase-anchoring protein 1; Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is re [...]
FLOT1 protein networkhttps://string-db.org/network/9606.ENSP00000365569Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
UBQLN1 protein networkhttps://string-db.org/network/9606.ENSP00000365576Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-a [...]
MDC1 protein networkhttps://string-db.org/network/9606.ENSP00000365588Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a [...]
GPR183 protein networkhttps://string-db.org/network/9606.ENSP00000365596G-protein coupled receptor 183; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and as [...]
IDNK protein networkhttps://string-db.org/network/9606.ENSP00000365601IDNK gluconokinase.
GRIPAP1 protein networkhttps://string-db.org/network/9606.ENSP00000365606GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of [...]
DHX16 protein networkhttps://string-db.org/network/9606.ENSP00000365625Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior t [...]
RASEF protein networkhttps://string-db.org/network/9606.ENSP00000365630Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP.
KIAA1217 protein networkhttps://string-db.org/network/9606.ENSP00000365637Sickle tail protein homolog; Required for normal development of intervertebral disks.
DOCK9 protein networkhttps://string-db.org/network/9606.ENSP00000365643Dedicator of cytokinesis protein 9; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.
NPPB protein networkhttps://string-db.org/network/9606.ENSP00000365651Brain natriuretic peptide 32; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis [...]
NPPA protein networkhttps://string-db.org/network/9606.ENSP00000365663Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoti [...]
OTUD1 protein networkhttps://string-db.org/network/9606.ENSP00000365678OTU domain-containing protein 1; Deubiquitinating enzyme that specifically hydrolyzes 'Lys- 63'-linked polyubiquitin to monoubiquitin.
TLE1 protein networkhttps://string-db.org/network/9606.ENSP00000365682Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activa [...]
SLC15A1 protein networkhttps://string-db.org/network/9606.ENSP00000365686Solute carrier family 15 member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digest [...]
PTF1A protein networkhttps://string-db.org/network/9606.ENSP00000365687Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role i [...]
PIM2 protein networkhttps://string-db.org/network/9606.ENSP00000365692Serine/threonine-protein kinase pim-2; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation [...]
MSRB2 protein networkhttps://string-db.org/network/9606.ENSP00000365693Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation [...]
PPP1R10 protein networkhttps://string-db.org/network/9606.ENSP00000365694Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of [...]
TTYH1 protein networkhttps://string-db.org/network/9606.ENSP00000365714Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family.
TLE4 protein networkhttps://string-db.org/network/9606.ENSP00000365720Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF fa [...]
ABHD12 protein networkhttps://string-db.org/network/9606.ENSP00000365725Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neur [...]
STK24 protein networkhttps://string-db.org/network/9606.ENSP00000365730Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase [...]
PRR3 protein networkhttps://string-db.org/network/9606.ENSP00000365744Proline-rich protein 3; Proline rich 3.
CTTN protein networkhttps://string-db.org/network/9606.ENSP00000365745Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulat [...]
KIAA2013 protein networkhttps://string-db.org/network/9606.ENSP00000365756Uncharacterized protein KIAA2013; KIAA2013.
PIP4K2A protein networkhttps://string-db.org/network/9606.ENSP00000365757Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phos [...]
MTHFR protein networkhttps://string-db.org/network/9606.ENSP00000365770Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
PSAT1 protein networkhttps://string-db.org/network/9606.ENSP00000365773Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Belon [...]
CEP78 protein networkhttps://string-db.org/network/9606.ENSP00000365782Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.
HDAC6 protein networkhttps://string-db.org/network/9606.ENSP00000365804Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
GNL1 protein networkhttps://string-db.org/network/9606.ENSP00000365806Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster.
GNA14 protein networkhttps://string-db.org/network/9606.ENSP00000365807Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
SPAG6 protein networkhttps://string-db.org/network/9606.ENSP00000365811Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.
HLA-E protein networkhttps://string-db.org/network/9606.ENSP00000365817Soluble HLA class I histocompatibility antigen, alpha chain E; Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2- [...]
SOWAHC protein networkhttps://string-db.org/network/9606.ENSP00000365830Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family.
PUS1 protein networkhttps://string-db.org/network/9606.ENSP00000365837tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an [...]
DPRX protein networkhttps://string-db.org/network/9606.ENSP00000365838Divergent paired-related homeobox; Putative transcription factor; Belongs to the paired homeobox family.
ENTPD6 protein networkhttps://string-db.org/network/9606.ENSP00000365840Ectonucleoside triphosphate diphosphohydrolase 6; Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleo [...]
TRIM39 protein networkhttps://string-db.org/network/9606.ENSP00000365844E3 ubiquitin-protein ligase TRIM39; [Isoform 1]: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly- ubiquitination and subsequent proteasome-mediated de [...]
BMI1 protein networkhttps://string-db.org/network/9606.ENSP00000365851Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, incl [...]
GATA1 protein networkhttps://string-db.org/network/9606.ENSP00000365858Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequenc [...]
MBNL2 protein networkhttps://string-db.org/network/9606.ENSP00000365861Muscleblind-like protein 2; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...]
NUDT8 protein networkhttps://string-db.org/network/9606.ENSP00000365883Nucleoside diphosphate-linked moiety X motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
TRIM15 protein networkhttps://string-db.org/network/9606.ENSP00000365884Tripartite motif containing 15; Belongs to the TRIM/RBCC family.
WAS protein networkhttps://string-db.org/network/9606.ENSP00000365891Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin pol [...]
HS6ST3 protein networkhttps://string-db.org/network/9606.ENSP00000365895Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...]
FOXB2 protein networkhttps://string-db.org/network/9606.ENSP00000365898Forkhead box protein B2; Transcription factor.
VSX1 protein networkhttps://string-db.org/network/9606.ENSP00000365899Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at [...]
PRUNE2 protein networkhttps://string-db.org/network/9606.ENSP00000365908Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
WDR13 protein networkhttps://string-db.org/network/9606.ENSP00000365919WD repeat domain 13.
TRIM31 protein networkhttps://string-db.org/network/9606.ENSP00000365924E3 ubiquitin-protein ligase TRIM31; Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family.
RFK protein networkhttps://string-db.org/network/9606.ENSP00000365926Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reac [...]
SP2 protein networkhttps://string-db.org/network/9606.ENSP00000365931Transcription factor Sp2; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites.
UGGT2 protein networkhttps://string-db.org/network/9606.ENSP00000365938UDP-glucose:glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality [...]
FBXO6 protein networkhttps://string-db.org/network/9606.ENSP00000365944F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (E [...]
RBM3 protein networkhttps://string-db.org/network/9606.ENSP00000365950RNA-binding protein 3; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microR [...]
FBXO44 protein networkhttps://string-db.org/network/9606.ENSP00000365959cDNA FLJ50458, highly similar to Homo sapiens F-box protein 44 (FBXO44), transcript variant 3, mRNA; F-box protein 44.
TBC1D25 protein networkhttps://string-db.org/network/9606.ENSP00000365962TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endoso [...]
PPP1R11 protein networkhttps://string-db.org/network/9606.ENSP00000365963E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammato [...]
UBIAD1 protein networkhttps://string-db.org/network/9606.ENSP00000366006UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentra [...]
NMRK1 protein networkhttps://string-db.org/network/9606.ENSP00000366007Nicotinamide riboside kinase 1; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucl [...]
ANGPTL7 protein networkhttps://string-db.org/network/9606.ENSP00000366015Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the [...]
HLA-G protein networkhttps://string-db.org/network/9606.ENSP00000366024Soluble HLA class I histocompatibility antigen, alpha chain G; [Isoform 1]: Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal [...]
CARNMT1 protein networkhttps://string-db.org/network/9606.ENSP00000366030Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine ( [...]
COMMD3 protein networkhttps://string-db.org/network/9606.ENSP00000366032COMM domain-containing protein 3; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B. Modulates Na(+) transport in epithelial ce [...]
KLK6 protein networkhttps://string-db.org/network/9606.ENSP00000366047Kallikrein-6; Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, my [...]
C9orf40 protein networkhttps://string-db.org/network/9606.ENSP00000366050Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40.
SYNDIG1 protein networkhttps://string-db.org/network/9606.ENSP00000366058Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin [...]
NMS protein networkhttps://string-db.org/network/9606.ENSP00000366061Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family.
RILPL1 protein networkhttps://string-db.org/network/9606.ENSP00000366070RILP-like protein 1; Plays a role in the regulation of cell shape and polarity (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia (By [...]
MOG protein networkhttps://string-db.org/network/9606.ENSP00000366091Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin s [...]
RORB protein networkhttps://string-db.org/network/9606.ENSP00000366093Nuclear receptor ROR-beta; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence [...]
YIF1A protein networkhttps://string-db.org/network/9606.ENSP00000366098Protein YIF1A; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the YIF1 family.
ANXA1 protein networkhttps://string-db.org/network/9606.ENSP00000366109Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a [...]
SSX1 protein networkhttps://string-db.org/network/9606.ENSP00000366118Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family.
EXOSC10 protein networkhttps://string-db.org/network/9606.ENSP00000366135Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation [...]
SOX21 protein networkhttps://string-db.org/network/9606.ENSP00000366144Transcription factor SOX-21; May play a role as an activator of transcription of OPRM1.
ZNF81 protein networkhttps://string-db.org/network/9606.ENSP00000366153Zinc finger protein 81; May be involved in transcriptional regulation.
SRM protein networkhttps://string-db.org/network/9606.ENSP00000366156Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low [...]
GPR180 protein networkhttps://string-db.org/network/9606.ENSP00000366157Integral membrane protein GPR180; G protein-coupled receptor 180.
ZFAND5 protein networkhttps://string-db.org/network/9606.ENSP00000366161AN1-type zinc finger protein 5; Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-media [...]
CST9 protein networkhttps://string-db.org/network/9606.ENSP00000366170Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Franc [...]
CBY3 protein networkhttps://string-db.org/network/9606.ENSP00000366173Chibby family member 3.
CST9L protein networkhttps://string-db.org/network/9606.ENSP00000366178Cystatin-9-like; Cystatin 9 like; Belongs to the cystatin family.
DNAJC1 protein networkhttps://string-db.org/network/9606.ENSP00000366179DnaJ homolog subfamily C member 1; May modulate protein synthesis.
ELK1 protein networkhttps://string-db.org/network/9606.ENSP00000366182ETS domain-containing protein Elk-1; Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) [...]
C1orf127 protein networkhttps://string-db.org/network/9606.ENSP00000366203Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127.
CST11 protein networkhttps://string-db.org/network/9606.ENSP00000366208Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family.
CASZ1 protein networkhttps://string-db.org/network/9606.ENSP00000366221Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
C9orf57 protein networkhttps://string-db.org/network/9606.ENSP00000366223Uncharacterized protein C9orf57; Chromosome 9 open reading frame 57.
GABBR1 protein networkhttps://string-db.org/network/9606.ENSP00000366233Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABB [...]
IL31 protein networkhttps://string-db.org/network/9606.ENSP00000366234Interleukin-31; Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell s [...]
DFFA protein networkhttps://string-db.org/network/9606.ENSP00000366237DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40).
ABHD17B protein networkhttps://string-db.org/network/9606.ENSP00000366240Alpha/beta hydrolase domain-containing protein 17B; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating ac [...]
CEMIP2 protein networkhttps://string-db.org/network/9606.ENSP00000366243Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan of approximately 5 k [...]
GPC6 protein networkhttps://string-db.org/network/9606.ENSP00000366246Secreted glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By sim [...]
CORT protein networkhttps://string-db.org/network/9606.ENSP00000366248Cortistatin-17; Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs; Belongs to the somatostatin family.
UBD protein networkhttps://string-db.org/network/9606.ENSP00000366249Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Prob [...]
ZNF41 protein networkhttps://string-db.org/network/9606.ENSP00000366265Zinc finger protein 41; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GPC5 protein networkhttps://string-db.org/network/9606.ENSP00000366267Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
KDM2B protein networkhttps://string-db.org/network/9606.ENSP00000366271Lysine-specific demethylase 2B; Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated [...]
ZNF157 protein networkhttps://string-db.org/network/9606.ENSP00000366273Zinc finger protein 157; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CNNM4 protein networkhttps://string-db.org/network/9606.ENSP00000366275Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a ro [...]
LMAN2L protein networkhttps://string-db.org/network/9606.ENSP00000366280VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
SLITRK5 protein networkhttps://string-db.org/network/9606.ENSP00000366283SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family.
SLITRK1 protein networkhttps://string-db.org/network/9606.ENSP00000366288SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth.
SLC25A39 protein networkhttps://string-db.org/network/9606.ENSP00000366299Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family.
SPRY2 protein networkhttps://string-db.org/network/9606.ENSP00000366306Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. Belongs to the sprouty family.
THBD protein networkhttps://string-db.org/network/9606.ENSP00000366307Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the ac [...]
TRPM3 protein networkhttps://string-db.org/network/9606.ENSP00000366314Transient receptor potential cation channel subfamily M member 3; Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by [...]
NEBL protein networkhttps://string-db.org/network/9606.ENSP00000366326Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Is [...]
KLF9 protein networkhttps://string-db.org/network/9606.ENSP00000366330Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with [...]
MAS1L protein networkhttps://string-db.org/network/9606.ENSP00000366331Mas-related G-protein coupled receptor MRG; MAS1 proto-oncogene like, G protein-coupled receptor.
OR2H1 protein networkhttps://string-db.org/network/9606.ENSP00000366340Olfactory receptor 2H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
NKX2-2 protein networkhttps://string-db.org/network/9606.ENSP00000366347Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying dien [...]
OR11A1 protein networkhttps://string-db.org/network/9606.ENSP00000366354Olfactory receptor 11A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2B3 protein networkhttps://string-db.org/network/9606.ENSP00000366378Putative olfactory receptor 2B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2W1 protein networkhttps://string-db.org/network/9606.ENSP00000366380Olfactory receptor 2W1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF311 protein networkhttps://string-db.org/network/9606.ENSP00000366384Zinc finger protein 311; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MAMDC2 protein networkhttps://string-db.org/network/9606.ENSP00000366387MAM domain containing 2.
SPDYC protein networkhttps://string-db.org/network/9606.ENSP00000366390Speedy protein C; Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 a [...]
SYVN1 protein networkhttps://string-db.org/network/9606.ENSP00000366395E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substr [...]
XRN2 protein networkhttps://string-db.org/network/9606.ENSP000003663965'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage a [...]
C9orf135 protein networkhttps://string-db.org/network/9606.ENSP00000366402Protein C9orf135; Chromosome 9 open reading frame 135.
TRIM27 protein networkhttps://string-db.org/network/9606.ENSP00000366404Zinc finger protein RFP; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'- linked polyubiquitin chains; the functi [...]
NMNAT1 protein networkhttps://string-db.org/network/9606.ENSP00000366410Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic aci [...]
POU4F1 protein networkhttps://string-db.org/network/9606.ENSP00000366413POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences [...]
EDNRB protein networkhttps://string-db.org/network/9606.ENSP00000366416Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger syst [...]
LZIC protein networkhttps://string-db.org/network/9606.ENSP00000366430Protein LZIC; Leucine zipper and CTNNBIP1 domain containing.
SNX15 protein networkhttps://string-db.org/network/9606.ENSP00000366452Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosom [...]
PLXDC2 protein networkhttps://string-db.org/network/9606.ENSP00000366460Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family.
ZKSCAN3 protein networkhttps://string-db.org/network/9606.ENSP00000366465Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses [...]
CTNNBIP1 protein networkhttps://string-db.org/network/9606.ENSP00000366474Beta-catenin-interacting protein 1; Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. Belongs to the CTNNBIP1 family.
ATG2A protein networkhttps://string-db.org/network/9606.ENSP00000366475Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell [...]
ARL5B protein networkhttps://string-db.org/network/9606.ENSP00000366487ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP.
PRKACG protein networkhttps://string-db.org/network/9606.ENSP00000366488cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
HRH2 protein networkhttps://string-db.org/network/9606.ENSP00000366506Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regula [...]
ZKSCAN4 protein networkhttps://string-db.org/network/9606.ENSP00000366509Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family.
CLSTN1 protein networkhttps://string-db.org/network/9606.ENSP00000366513Soluble Alc-alpha; Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances AP [...]
NSUN6 protein networkhttps://string-db.org/network/9606.ENSP00000366519tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(G [...]
ARHGAP39 protein networkhttps://string-db.org/network/9606.ENSP00000366522Rho GTPase activating protein 39.
FTL protein networkhttps://string-db.org/network/9606.ENSP00000366525Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after ox [...]
ZSCAN16 protein networkhttps://string-db.org/network/9606.ENSP00000366527Zinc finger and SCAN domain-containing protein 16; May be involved in transcriptional regulation.
TMEM252 protein networkhttps://string-db.org/network/9606.ENSP00000366528Transmembrane protein 252.
FOXH1 protein networkhttps://string-db.org/network/9606.ENSP00000366534Forkhead box protein H1; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin si [...]
ZNF165 protein networkhttps://string-db.org/network/9606.ENSP00000366542Zinc finger protein 165; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CRNKL1 protein networkhttps://string-db.org/network/9606.ENSP00000366557Crooked neck-like protein 1; Involved in pre-mRNA splicing process. Belongs to the crooked-neck family.
PIK3CD protein networkhttps://string-db.org/network/9606.ENSP00000366563Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to gener [...]
VPS28 protein networkhttps://string-db.org/network/9606.ENSP00000366565Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.
INSYN2B protein networkhttps://string-db.org/network/9606.ENSP00000366582Protein INSYN2B; Inhibitory synaptic factor family member 2B; Belongs to the INSYN2 family.
SLC39A12 protein networkhttps://string-db.org/network/9606.ENSP00000366586Zinc transporter ZIP12; Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia; Belongs to the ZIP transporter (TC 2.A.5) family.
SF1 protein networkhttps://string-db.org/network/9606.ENSP00000366604Splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repr [...]
CBWD6 protein networkhttps://string-db.org/network/9606.ENSP00000366608COBW domain containing 6; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
CBWD1 protein networkhttps://string-db.org/network/9606.ENSP00000366617COBW domain containing 1.
H2BC13 protein networkhttps://string-db.org/network/9606.ENSP00000366618Histone H2B type 1-L; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
GPR157 protein networkhttps://string-db.org/network/9606.ENSP00000366628G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activat [...]
FOXD4L4 protein networkhttps://string-db.org/network/9606.ENSP00000366630Forkhead box D4 like 4.
FOXD4L5 protein networkhttps://string-db.org/network/9606.ENSP00000366637Forkhead box D4 like 5.
SLC2A5 protein networkhttps://string-db.org/network/9606.ENSP00000366641Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxygluc [...]
SCP2D1 protein networkhttps://string-db.org/network/9606.ENSP00000366645SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1.
CA6 protein networkhttps://string-db.org/network/9606.ENSP00000366654Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown.
H2AC12 protein networkhttps://string-db.org/network/9606.ENSP00000366679H2A clustered histone 12.
ACOD1 protein networkhttps://string-db.org/network/9606.ENSP00000366682Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimu [...]
SPATC1 protein networkhttps://string-db.org/network/9606.ENSP00000366690Speriolin; Spermatogenesis and centriole associated 1; Belongs to the speriolin family.
KCTD12 protein networkhttps://string-db.org/network/9606.ENSP00000366694BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...]
ERRFI1 protein networkhttps://string-db.org/network/9606.ENSP00000366702ERBB receptor feedback inhibitor 1; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inh [...]
TMEM236 protein networkhttps://string-db.org/network/9606.ENSP00000366715Transmembrane protein 236.
STAM protein networkhttps://string-db.org/network/9606.ENSP00000366746Signal transducing adapter molecule 1; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leadi [...]
AUP1 protein networkhttps://string-db.org/network/9606.ENSP00000366748Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; [...]
LMO7 protein networkhttps://string-db.org/network/9606.ENSP00000366757LIM domain 7.
HECTD4 protein networkhttps://string-db.org/network/9606.ENSP00000366783Probable E3 ubiquitin-protein ligase HECTD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...]
LBX2 protein networkhttps://string-db.org/network/9606.ENSP00000366789Transcription factor LBX2; Putative transcription factor.
SLC22A12 protein networkhttps://string-db.org/network/9606.ENSP00000366797Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate a [...]
HMGN4 protein networkhttps://string-db.org/network/9606.ENSP00000366798High mobility group nucleosomal binding domain 4; Belongs to the HMGN family.
DNAJC11 protein networkhttps://string-db.org/network/9606.ENSP00000366800DnaJ homolog subfamily C member 11; [Isoform 1]: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial out [...]
UCHL3 protein networkhttps://string-db.org/network/9606.ENSP00000366819Ubiquitin carboxyl-terminal hydrolase isozyme L3; Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. T [...]
ANKRD20A2 protein networkhttps://string-db.org/network/9606.ENSP00000366826Ankyrin repeat domain-containing protein 20A2.
ST8SIA6 protein networkhttps://string-db.org/network/9606.ENSP00000366827Alpha-2,8-sialyltransferase 8F; Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)- Gal sequence at the non-reducing en [...]
POLR3F protein networkhttps://string-db.org/network/9606.ENSP00000366828DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
TBC1D4 protein networkhttps://string-db.org/network/9606.ENSP00000366863TBC1 domain family member 4; May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the pla [...]
PHF13 protein networkhttps://string-db.org/network/9606.ENSP00000366876PHD finger protein 13; Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.
KLHL21 protein networkhttps://string-db.org/network/9606.ENSP00000366886Kelch-like protein 21; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiq [...]
KLF12 protein networkhttps://string-db.org/network/9606.ENSP00000366897Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
HIF3A protein networkhttps://string-db.org/network/9606.ENSP00000366898Hypoxia-inducible factor 3-alpha; Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression. Functions as an inhibit [...]
FAM216A protein networkhttps://string-db.org/network/9606.ENSP00000366901Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family.
ZBTB48 protein networkhttps://string-db.org/network/9606.ENSP00000366902Telomere zinc finger-associated protein; Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially bin [...]
KLF5 protein networkhttps://string-db.org/network/9606.ENSP00000366915Krueppel-like factor 5; Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes; Belongs to the krueppel C2H2-type zinc-finger protein family.
IGFBPL1 protein networkhttps://string-db.org/network/9606.ENSP00000366923Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs i [...]
IGFL4 protein networkhttps://string-db.org/network/9606.ENSP00000366926IGF like family member 4; Belongs to the IGFL family.
ALDH1B1 protein networkhttps://string-db.org/network/9606.ENSP00000366927Aldehyde dehydrogenase X, mitochondrial; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, n [...]
NOL9 protein networkhttps://string-db.org/network/9606.ENSP00000366934Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more [...]
SHB protein networkhttps://string-db.org/network/9606.ENSP00000366936SH2 domain-containing adapter protein B; Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in [...]
BTN3A2 protein networkhttps://string-db.org/network/9606.ENSP00000366937Butyrophilin subfamily 3 member A2; Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. Belongs to the immunoglobulin superfamil [...]
MGME1 protein networkhttps://string-db.org/network/9606.ENSP00000366939Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity [...]
SLC36A3 protein networkhttps://string-db.org/network/9606.ENSP00000366942Proton-coupled amino acid transporter 3; Solute carrier family 36 member 3.
SLC25A51 protein networkhttps://string-db.org/network/9606.ENSP00000366945Solute carrier family 25 member 51.
KRTAP9-2 protein networkhttps://string-db.org/network/9606.ENSP00000366950Keratin-associated protein 9-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
DCAF10 protein networkhttps://string-db.org/network/9606.ENSP00000366953DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF10 family.
KRTAP4-2 protein networkhttps://string-db.org/network/9606.ENSP00000366955Keratin associated protein 4-2.
H2BC10 protein networkhttps://string-db.org/network/9606.ENSP00000366962H2B clustered histone 10.
GPR20 protein networkhttps://string-db.org/network/9606.ENSP00000366970G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP.
H4C2 protein networkhttps://string-db.org/network/9606.ENSP00000366974H4 clustered histone 2.
KRTAP1-4 protein networkhttps://string-db.org/network/9606.ENSP00000366976Keratin-associated protein 1-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRT40 protein networkhttps://string-db.org/network/9606.ENSP00000366984Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family.
DIS3 protein networkhttps://string-db.org/network/9606.ENSP00000366997Exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and [...]
SNX5 protein networkhttps://string-db.org/network/9606.ENSP00000366998Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphat [...]
H3C4 protein networkhttps://string-db.org/network/9606.ENSP00000366999H3 clustered histone 4.
DPP6 protein networkhttps://string-db.org/network/9606.ENSP00000367001Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no [...]
TNFRSF25 protein networkhttps://string-db.org/network/9606.ENSP00000367013Tumor necrosis factor receptor superfamily member 25; Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May pla [...]
H2AC6 protein networkhttps://string-db.org/network/9606.ENSP00000367022Histone H2A type 1-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
NAA40 protein networkhttps://string-db.org/network/9606.ENSP00000367024N-alpha-acetyltransferase 40; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha- acetyltransfera [...]
TCOF1 protein networkhttps://string-db.org/network/9606.ENSP00000367028Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neu [...]
POLR1E protein networkhttps://string-db.org/network/9606.ENSP00000367029DNA-directed RNA polymerase I subunit RPA49; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
TRDMT1 protein networkhttps://string-db.org/network/9606.ENSP00000367030tRNA (cytosine(38)-C(5))-methyltransferase; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
PLCXD3 protein networkhttps://string-db.org/network/9606.ENSP00000367032PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3.
H4C3 protein networkhttps://string-db.org/network/9606.ENSP00000367034H4 clustered histone 3.
RRBP1 protein networkhttps://string-db.org/network/9606.ENSP00000367038Ribosome binding protein 1.
MZT1 protein networkhttps://string-db.org/network/9606.ENSP00000367049Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome; Belongs to the MOZART1 family.
RTN3 protein networkhttps://string-db.org/network/9606.ENSP00000367050Reticulon-3; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. [...]
CUBN protein networkhttps://string-db.org/network/9606.ENSP00000367064Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoprotein [...]
ZFAT protein networkhttps://string-db.org/network/9606.ENSP00000367069Zinc finger protein ZFAT; May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulat [...]
KLHL1 protein networkhttps://string-db.org/network/9606.ENSP00000367075Kelch-like protein 1; May play a role in organizing the actin cytoskeleton of the brain cells.
SLC17A2 protein networkhttps://string-db.org/network/9606.ENSP00000367081Sodium-dependent phosphate transport protein 3; May be involved in actively transporting phosphate into cells via Na(+) cotransport; Belongs to the major facilitator superfamily. Sodium/anion cot [...]
ACOT7 protein networkhttps://string-db.org/network/9606.ENSP00000367086Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...]
PCDH9 protein networkhttps://string-db.org/network/9606.ENSP00000367096Protocadherin-9; Potential calcium-dependent cell-adhesion protein.
SLC22A6 protein networkhttps://string-db.org/network/9606.ENSP00000367102Solute carrier family 22 member 6; Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic an [...]
BFSP1 protein networkhttps://string-db.org/network/9606.ENSP00000367104Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. Involved in altering the calcium regulatio [...]
SLC3A2 protein networkhttps://string-db.org/network/9606.ENSP000003671234F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer. The h [...]
GPR153 protein networkhttps://string-db.org/network/9606.ENSP00000367125Probable G-protein coupled receptor 153; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
HES3 protein networkhttps://string-db.org/network/9606.ENSP00000367130Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription.
SLC17A4 protein networkhttps://string-db.org/network/9606.ENSP00000367137Probable small intestine urate exporter; Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate ex [...]
SPINK9 protein networkhttps://string-db.org/network/9606.ENSP00000367139Serine protease inhibitor Kazal-type 9; Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
PCDH17 protein networkhttps://string-db.org/network/9606.ENSP00000367151Protocadherin-17; Potential calcium-dependent cell-adhesion protein.
RSU1 protein networkhttps://string-db.org/network/9606.ENSP00000367154Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.
LRRC3C protein networkhttps://string-db.org/network/9606.ENSP00000367157Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C.
PRR20B protein networkhttps://string-db.org/network/9606.ENSP00000367163Proline-rich protein 20A; Proline rich 20B; Belongs to the PRR20 family.
PRR20A protein networkhttps://string-db.org/network/9606.ENSP00000367164Proline rich 20A.
RNF207 protein networkhttps://string-db.org/network/9606.ENSP00000367173RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export f [...]
PCDH8 protein networkhttps://string-db.org/network/9606.ENSP00000367177Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involve [...]
LYPD5 protein networkhttps://string-db.org/network/9606.ENSP00000367185LY6/PLAUR domain containing 5.
FBXO48 protein networkhttps://string-db.org/network/9606.ENSP00000367193F-box protein 48.
GLIPR2 protein networkhttps://string-db.org/network/9606.ENSP00000367196Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2.
SCGN protein networkhttps://string-db.org/network/9606.ENSP00000367197Secretagogin, EF-hand calcium binding protein.
CNMD protein networkhttps://string-db.org/network/9606.ENSP00000367198Leukocyte cell-derived chemotaxin 1; Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the gro [...]
RECK protein networkhttps://string-db.org/network/9606.ENSP00000367202Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key r [...]
KDM6A protein networkhttps://string-db.org/network/9606.ENSP00000367203Lysine-specific demethylase 6A; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethyla [...]
SUGT1 protein networkhttps://string-db.org/network/9606.ENSP00000367208Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
GRXCR2 protein networkhttps://string-db.org/network/9606.ENSP00000367214Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection.
OR13J1 protein networkhttps://string-db.org/network/9606.ENSP00000367219Olfactory receptor 13J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ACTR2 protein networkhttps://string-db.org/network/9606.ENSP00000367220Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 c [...]
CEP68 protein networkhttps://string-db.org/network/9606.ENSP00000367229Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to [...]
TMEM8B protein networkhttps://string-db.org/network/9606.ENSP00000367230Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family.
PTER protein networkhttps://string-db.org/network/9606.ENSP00000367239Phosphotriesterase-related protein; Phosphotriesterase related; Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
AHNAK protein networkhttps://string-db.org/network/9606.ENSP00000367263Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.
CKAP4 protein networkhttps://string-db.org/network/9606.ENSP00000367265Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF.
CKAP2 protein networkhttps://string-db.org/network/9606.ENSP00000367276Cytoskeleton-associated protein 2; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53- dependent manner (By similarity).
FUNDC1 protein networkhttps://string-db.org/network/9606.ENSP00000367284FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
VPS36 protein networkhttps://string-db.org/network/9606.ENSP00000367299Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation [...]
ZNF425 protein networkhttps://string-db.org/network/9606.ENSP00000367300Zinc finger protein 425; Acts as a transcriptional repressor.
MAOB protein networkhttps://string-db.org/network/9606.ENSP00000367309Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in th [...]
SEL1L2 protein networkhttps://string-db.org/network/9606.ENSP00000367312Protein sel-1 homolog 2; SEL1L2 adaptor subunit of ERAD E3 ligase; Belongs to the sel-1 family.
LRRC10B protein networkhttps://string-db.org/network/9606.ENSP00000367315Leucine-rich repeat-containing protein 10B; Leucine rich repeat containing 10B.
ITGA8 protein networkhttps://string-db.org/network/9606.ENSP00000367316Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures [...]
RGP1 protein networkhttps://string-db.org/network/9606.ENSP00000367318RAB6A-GEF complex partner protein 2; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required [...]
FBXO47 protein networkhttps://string-db.org/network/9606.ENSP00000367319F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
KCNAB2 protein networkhttps://string-db.org/network/9606.ENSP00000367323Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of ne [...]
C12orf73 protein networkhttps://string-db.org/network/9606.ENSP00000367330Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73.
GBA2 protein networkhttps://string-db.org/network/9606.ENSP00000367343Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. Glucosylceramides are membrane glycosph [...]
NDUFAF5 protein networkhttps://string-db.org/network/9606.ENSP00000367346Arginine-hydroxylase NDUFAF5, mitochondrial; Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT- ND1) at early stages. Acts by me [...]
C12orf42 protein networkhttps://string-db.org/network/9606.ENSP00000367353Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42.
ARHGEF35 protein networkhttps://string-db.org/network/9606.ENSP00000367355Rho guanine nucleotide exchange factor 35.
FAM171A1 protein networkhttps://string-db.org/network/9606.ENSP00000367356Protein FAM171A1; Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation. Belongs to the FAM171 family.
C6orf62 protein networkhttps://string-db.org/network/9606.ENSP00000367359Uncharacterized protein C6orf62; Chromosome 6 open reading frame 62.
GPR34 protein networkhttps://string-db.org/network/9606.ENSP00000367384Probable G-protein coupled receptor 34; Orphan receptor.
PGA4 protein networkhttps://string-db.org/network/9606.ENSP00000367391Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
NPHP4 protein networkhttps://string-db.org/network/9606.ENSP00000367398Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for bu [...]
TAF2 protein networkhttps://string-db.org/network/9606.ENSP00000367406Transcription initiation factor TFIID subunit 2; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeri [...]
NMT2 protein networkhttps://string-db.org/network/9606.ENSP00000367407Glycylpeptide N-tetradecanoyltransferase 2; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins; Belongs to the NMT family.
MS4A13 protein networkhttps://string-db.org/network/9606.ENSP00000367428Membrane-spanning 4-domains subfamily A member 13; May be involved in signal transduction as a component of a multimeric receptor complex.
ERICH4 protein networkhttps://string-db.org/network/9606.ENSP00000367429Glutamate-rich protein 4; Glutamate rich 4.
AJAP1 protein networkhttps://string-db.org/network/9606.ENSP00000367433Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration.
TDP2 protein networkhttps://string-db.org/network/9606.ENSP00000367440Tyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phospha [...]
EXT1 protein networkhttps://string-db.org/network/9606.ENSP00000367446Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appe [...]
ACBD7 protein networkhttps://string-db.org/network/9606.ENSP00000367453Acyl-CoA-binding domain-containing protein 7; Binds medium- and long-chain acyl-CoA esters.
KIAA0319 protein networkhttps://string-db.org/network/9606.ENSP00000367459Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a ro [...]
OLAH protein networkhttps://string-db.org/network/9606.ENSP00000367462S-acyl fatty acid synthase thioesterase, medium chain; Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of f [...]
CEP104 protein networkhttps://string-db.org/network/9606.ENSP00000367476Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip.
SPIRE2 protein networkhttps://string-db.org/network/9606.ENSP00000367494Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibe [...]
LRRC47 protein networkhttps://string-db.org/network/9606.ENSP00000367498Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47.
DCLRE1C protein networkhttps://string-db.org/network/9606.ENSP00000367527Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, [...]
AARD protein networkhttps://string-db.org/network/9606.ENSP00000367528Alanine and arginine rich domain containing protein.
TP73 protein networkhttps://string-db.org/network/9606.ENSP00000367545Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block [...]
RCBTB1 protein networkhttps://string-db.org/network/9606.ENSP00000367552RCC1 and BTB domain-containing protein 1; May be involved in cell cycle regulation by chromatin remodeling.
C19orf54 protein networkhttps://string-db.org/network/9606.ENSP00000367564UPF0692 protein C19orf54; Chromosome 19 open reading frame 54.
PHF11 protein networkhttps://string-db.org/network/9606.ENSP00000367570PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression.
REEP2 protein networkhttps://string-db.org/network/9606.ENSP00000367590Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By simila [...]
TPRG1L protein networkhttps://string-db.org/network/9606.ENSP00000367595Tumor protein p63-regulated gene 1-like protein; Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of [...]
CA9 protein networkhttps://string-db.org/network/9606.ENSP00000367608Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specifi [...]
APRT protein networkhttps://string-db.org/network/9606.ENSP00000367615Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
HSPA14 protein networkhttps://string-db.org/network/9606.ENSP00000367623Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC compl [...]
ARHGEF16 protein networkhttps://string-db.org/network/9606.ENSP00000367629Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migrat [...]
ARHGEF39 protein networkhttps://string-db.org/network/9606.ENSP00000367638Rho guanine nucleotide exchange factor 39; Promotes cell proliferation.
ANKEF1 protein networkhttps://string-db.org/network/9606.ENSP00000367644Ankyrin repeat and EF-hand domain containing 1.
OR5D16 protein networkhttps://string-db.org/network/9606.ENSP00000367649Olfactory receptor 5D16; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5L2 protein networkhttps://string-db.org/network/9606.ENSP00000367650Olfactory receptor 5L2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PKHD1L1 protein networkhttps://string-db.org/network/9606.ENSP00000367655Fibrocystin-L; PKHD1 like 1.
ACTRT2 protein networkhttps://string-db.org/network/9606.ENSP00000367658Actin related protein T2.
OR4A5 protein networkhttps://string-db.org/network/9606.ENSP00000367664Olfactory receptor 4A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MMEL1 protein networkhttps://string-db.org/network/9606.ENSP00000367668Membrane metallo-endopeptidase-like 1, soluble form; Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a [...]
PAK5 protein networkhttps://string-db.org/network/9606.ENSP00000367686Serine/threonine-protein kinase PAK 5; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferat [...]
LPAR6 protein networkhttps://string-db.org/network/9606.ENSP00000367691Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and [...]
BCOR protein networkhttps://string-db.org/network/9606.ENSP00000367705BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This [...]
HES5 protein networkhttps://string-db.org/network/9606.ENSP00000367714Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
DCDC2 protein networkhttps://string-db.org/network/9606.ENSP00000367715Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral [...]
NUP160 protein networkhttps://string-db.org/network/9606.ENSP00000367721Nuclear pore complex protein Nup160; Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport.
NRSN1 protein networkhttps://string-db.org/network/9606.ENSP00000367739Neurensin-1; May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory con [...]
TSPAN7 protein networkhttps://string-db.org/network/9606.ENSP00000367743Tetraspanin-7; May be involved in cell proliferation and cell motility.
PLCH2 protein networkhttps://string-db.org/network/9606.ENSP000003677471-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activa [...]
CLLU1OS protein networkhttps://string-db.org/network/9606.ENSP00000367748Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.
CAMKMT protein networkhttps://string-db.org/network/9606.ENSP00000367755Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin. Belongs to the class I-like SAM-binding methyltransferase superfamily. CLNMT methyltransferase fami [...]
PLCB4 protein networkhttps://string-db.org/network/9606.ENSP000003677621-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...]
SLC35B4 protein networkhttps://string-db.org/network/9606.ENSP00000367770UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into G [...]
LIG3 protein networkhttps://string-db.org/network/9606.ENSP00000367787DNA ligase 3; Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment w [...]
MORN1 protein networkhttps://string-db.org/network/9606.ENSP00000367792MORN repeat containing 1.
SRPX protein networkhttps://string-db.org/network/9606.ENSP00000367794Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction.
SKI protein networkhttps://string-db.org/network/9606.ENSP00000367797Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. B [...]
RPS16 protein networkhttps://string-db.org/network/9606.ENSP00000367806Ribosomal protein S16.
DNAAF1 protein networkhttps://string-db.org/network/9606.ENSP00000367815Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation [...]
PODXL protein networkhttps://string-db.org/network/9606.ENSP00000367817Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neigh [...]
FAM214B protein networkhttps://string-db.org/network/9606.ENSP00000367823Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family.
PRKCZ protein networkhttps://string-db.org/network/9606.ENSP00000367830Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein ( [...]
CCL7 protein networkhttps://string-db.org/network/9606.ENSP00000367832C-C motif chemokine 7; Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This prote [...]
PRPF18 protein networkhttps://string-db.org/network/9606.ENSP00000367835Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing.
DYNLT3 protein networkhttps://string-db.org/network/9606.ENSP00000367841Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to a [...]
GABRD protein networkhttps://string-db.org/network/9606.ENSP00000367848Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...]
CYBB protein networkhttps://string-db.org/network/9606.ENSP00000367851Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single e [...]
GNB1 protein networkhttps://string-db.org/network/9606.ENSP00000367872Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...]
C11orf49 protein networkhttps://string-db.org/network/9606.ENSP00000367878UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family.
XK protein networkhttps://string-db.org/network/9606.ENSP00000367879Membrane transport protein XK; May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.
PIGO protein networkhttps://string-db.org/network/9606.ENSP00000367880GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannos [...]
LANCL3 protein networkhttps://string-db.org/network/9606.ENSP00000367882LanC-like protein 3; LanC like 3.
LRP4 protein networkhttps://string-db.org/network/9606.ENSP00000367888Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a [...]
NADK protein networkhttps://string-db.org/network/9606.ENSP00000367890NAD kinase; Belongs to the NAD kinase family.
LGALS7 protein networkhttps://string-db.org/network/9606.ENSP00000367891Galectin 7.
SEPHS1 protein networkhttps://string-db.org/network/9606.ENSP00000367893Selenide, water dikinase 1; Synthesizes selenophosphate from selenide and ATP.
CDK11A protein networkhttps://string-db.org/network/9606.ENSP00000367900Cyclin-dependent kinase 11A; Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potent [...]
FANCG protein networkhttps://string-db.org/network/9606.ENSP00000367910Fanconi anemia group G protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...]
SYCE1L protein networkhttps://string-db.org/network/9606.ENSP00000367911Synaptonemal complex central element protein 1-like; May be involved in meiosis.
FAM47C protein networkhttps://string-db.org/network/9606.ENSP00000367913Putative protein FAM47C; Family with sequence similarity 47 member C; Belongs to the FAM47 family.
CFAP47 protein networkhttps://string-db.org/network/9606.ENSP00000367922Cilia and flagella associated protein 47.
OXER1 protein networkhttps://string-db.org/network/9606.ENSP00000367930Oxoeicosanoid receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)- hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic [...]
COX7A2L protein networkhttps://string-db.org/network/9606.ENSP00000367938Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitoch [...]
UQCRQ protein networkhttps://string-db.org/network/9606.ENSP00000367939Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which dr [...]
GDF9 protein networkhttps://string-db.org/network/9606.ENSP00000367942Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S [...]
SHROOM1 protein networkhttps://string-db.org/network/9606.ENSP00000367950Protein Shroom1; May be involved in the assembly of microtubule arrays during cell elongation.
UCMA protein networkhttps://string-db.org/network/9606.ENSP00000367952Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of f [...]
SOWAHA protein networkhttps://string-db.org/network/9606.ENSP00000367965Ankyrin repeat domain-containing protein SOWAHA; Sosondowah ankyrin repeat domain family member A; Belongs to the SOWAH family.
GLIPR1L1 protein networkhttps://string-db.org/network/9606.ENSP00000367967GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins [...]
ID4 protein networkhttps://string-db.org/network/9606.ENSP00000367972DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...]
SEPTIN8 protein networkhttps://string-db.org/network/9606.ENSP00000367991Septin-8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles (By simi [...]
ESD protein networkhttps://string-db.org/network/9606.ENSP00000367992S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.
TMEM240 protein networkhttps://string-db.org/network/9606.ENSP00000368007Transmembrane protein 240; Belongs to the TMEM240 family.
PAX4 protein networkhttps://string-db.org/network/9606.ENSP00000368014Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, [...]
ZFC3H1 protein networkhttps://string-db.org/network/9606.ENSP00000368017Zinc finger C3H1 domain-containing protein; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exos [...]
OPTN protein networkhttps://string-db.org/network/9606.ENSP00000368022Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi [...]
ATAD3A protein networkhttps://string-db.org/network/9606.ENSP00000368030ATPase family AAA domain-containing protein 3A; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important ro [...]
ATAD3C protein networkhttps://string-db.org/network/9606.ENSP00000368062ATPase family AAA domain containing 3C; Belongs to the AAA ATPase family.
HAO1 protein networkhttps://string-db.org/network/9606.ENSP00000368066Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palm [...]
CYP4V2 protein networkhttps://string-db.org/network/9606.ENSP00000368079Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the [...]
RAD50 protein networkhttps://string-db.org/network/9606.ENSP00000368100DNA repair protein RAD50; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The compl [...]
CCDC3 protein networkhttps://string-db.org/network/9606.ENSP00000368102Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in EC [...]
BMP2 protein networkhttps://string-db.org/network/9606.ENSP00000368104Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 st [...]
ACCSL protein networkhttps://string-db.org/network/9606.ENSP00000368109Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotra [...]
GALT protein networkhttps://string-db.org/network/9606.ENSP00000368119Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism.
C4orf47 protein networkhttps://string-db.org/network/9606.ENSP00000368127UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family.
LRRN4 protein networkhttps://string-db.org/network/9606.ENSP00000368135Leucine-rich repeat neuronal protein 4; May play an important role in hippocampus-dependent long- lasting memory.
CRLS1 protein networkhttps://string-db.org/network/9606.ENSP00000368140Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylg [...]
PRR5L protein networkhttps://string-db.org/network/9606.ENSP00000368144Proline-rich protein 5-like; Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 com [...]
ALKBH6 protein networkhttps://string-db.org/network/9606.ENSP00000368152Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha- ketoglutarate and iron; Belongs to the alkB family.
MCM8 protein networkhttps://string-db.org/network/9606.ENSP00000368164DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (H [...]
SDHAF1 protein networkhttps://string-db.org/network/9606.ENSP00000368165Succinate dehydrogenase assembly factor 1, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...]
DVL1 protein networkhttps://string-db.org/network/9606.ENSP00000368166Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream [...]
DHRS13 protein networkhttps://string-db.org/network/9606.ENSP00000368173Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase.
ARID3C protein networkhttps://string-db.org/network/9606.ENSP00000368189AT-rich interactive domain-containing protein 3C; AT-rich interaction domain 3C.
NPHS1 protein networkhttps://string-db.org/network/9606.ENSP00000368190Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the [...]
PGPEP1L protein networkhttps://string-db.org/network/9606.ENSP00000368199Pyroglutamyl-peptidase 1-like protein; Pyroglutamyl-peptidase I like.
FTHL17 protein networkhttps://string-db.org/network/9606.ENSP00000368207Ferritin heavy chain like 17.
TAB3 protein networkhttps://string-db.org/network/9606.ENSP00000368215TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays [...]
ATL2 protein networkhttps://string-db.org/network/9606.ENSP00000368237Atlastin-2; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...]
CHGB protein networkhttps://string-db.org/network/9606.ENSP00000368244Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
CXorf21 protein networkhttps://string-db.org/network/9606.ENSP00000368245Protein CXorf21; Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses.
NR0B1 protein networkhttps://string-db.org/network/9606.ENSP00000368253Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulat [...]
MAGEB1 protein networkhttps://string-db.org/network/9606.ENSP00000368264Melanoma-associated antigen B1; MAGE family member B1.
CNTFR protein networkhttps://string-db.org/network/9606.ENSP00000368265Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and C [...]
MAGEB4 protein networkhttps://string-db.org/network/9606.ENSP00000368266Melanoma-associated antigen B4; MAGE family member B4.
MAGEB2 protein networkhttps://string-db.org/network/9606.ENSP00000368273Melanoma-associated antigen B2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...]
IL1RAPL1 protein networkhttps://string-db.org/network/9606.ENSP00000368278Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate th [...]
C11orf91 protein networkhttps://string-db.org/network/9606.ENSP00000368296Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91.
MAGEB10 protein networkhttps://string-db.org/network/9606.ENSP00000368304Melanoma-associated antigen B10; MAGE family member B10.
GPCPD1 protein networkhttps://string-db.org/network/9606.ENSP00000368305Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activit [...]
NRCAM protein networkhttps://string-db.org/network/9606.ENSP00000368314Neuronal cell adhesion molecule; Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth [...]
PUSL1 protein networkhttps://string-db.org/network/9606.ENSP00000368318Pseudouridine synthase like 1; Belongs to the tRNA pseudouridine synthase TruA family.
MAGEB6 protein networkhttps://string-db.org/network/9606.ENSP00000368320Melanoma-associated antigen B6; MAGE family member B6.
ARX protein networkhttps://string-db.org/network/9606.ENSP00000368332Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the [...]
RBM24 protein networkhttps://string-db.org/network/9606.ENSP00000368341RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiati [...]
PRKD3 protein networkhttps://string-db.org/network/9606.ENSP00000368356Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similar [...]
POLA1 protein networkhttps://string-db.org/network/9606.ENSP00000368358DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiat [...]
FABP9 protein networkhttps://string-db.org/network/9606.ENSP00000368362Fatty acid binding protein 9.
WT1 protein networkhttps://string-db.org/network/9606.ENSP00000368370Wilms tumor protein; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expre [...]
NGRN protein networkhttps://string-db.org/network/9606.ENSP00000368389Neugrin; Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitocho [...]
LYRM9 protein networkhttps://string-db.org/network/9606.ENSP00000368397LYR motif containing 9; Belongs to the complex I LYR family. LYRM9 subfamily.
KCTD4 protein networkhttps://string-db.org/network/9606.ENSP00000368402BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4.
SCNN1D protein networkhttps://string-db.org/network/9606.ENSP00000368411Amiloride-sensitive sodium channel subunit delta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...]
BCAP29 protein networkhttps://string-db.org/network/9606.ENSP00000368414B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8- mediated apoptosis (By [...]
PCYT1B protein networkhttps://string-db.org/network/9606.ENSP00000368439Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis.
GPALPP1 protein networkhttps://string-db.org/network/9606.ENSP00000368447GPALPP motifs containing 1.
CD83 protein networkhttps://string-db.org/network/9606.ENSP00000368450CD83 antigen; May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
NUDT2 protein networkhttps://string-db.org/network/9606.ENSP00000368452Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis; Belongs to the Nudix hydrolase family.
PCNA protein networkhttps://string-db.org/network/9606.ENSP00000368458Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elo [...]
NUFIP1 protein networkhttps://string-db.org/network/9606.ENSP00000368459Nuclear fragile X mental retardation-interacting protein 1; Binds RNA.
MCUR1 protein networkhttps://string-db.org/network/9606.ENSP00000368468Mitochondrial calcium uniporter regulator 1; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calciu [...]
SERP2 protein networkhttps://string-db.org/network/9606.ENSP00000368477Stress-associated endoplasmic reticulum protein 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against [...]
ZFX protein networkhttps://string-db.org/network/9606.ENSP00000368486Zinc finger X-chromosomal protein; Probable transcriptional activator.
B3GALT6 protein networkhttps://string-db.org/network/9606.ENSP00000368496Beta-1,3-galactosyltransferase 6; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for gala [...]
C4orf46 protein networkhttps://string-db.org/network/9606.ENSP00000368503Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46.
CXorf58 protein networkhttps://string-db.org/network/9606.ENSP00000368511Putative uncharacterized protein CXorf58; Chromosome X open reading frame 58.
LGR4 protein networkhttps://string-db.org/network/9606.ENSP00000368516Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon [...]
ECHDC3 protein networkhttps://string-db.org/network/9606.ENSP00000368517Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; May play a role in fatty acid biosynthesis and insulin sensitivity; Belongs to the enoyl-CoA hydratase/isomerase family.
DNAJC15 protein networkhttps://string-db.org/network/9606.ENSP00000368523DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By sim [...]
APOO protein networkhttps://string-db.org/network/9606.ENSP00000368528MICOS complex subunit MIC26; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
TNFRSF4 protein networkhttps://string-db.org/network/9606.ENSP00000368538Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
VIT protein networkhttps://string-db.org/network/9606.ENSP00000368544Vitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells.
FEZ2 protein networkhttps://string-db.org/network/9606.ENSP00000368547Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation.
DNAJC2 protein networkhttps://string-db.org/network/9606.ENSP00000368565DnaJ homolog subfamily C member 2, N-terminally processed; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: comp [...]
SAT1 protein networkhttps://string-db.org/network/9606.ENSP00000368572Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly r [...]
GFOD1 protein networkhttps://string-db.org/network/9606.ENSP00000368589Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family.
TTLL10 protein networkhttps://string-db.org/network/9606.ENSP00000368592Inactive polyglycylase TTLL10; Inactive polyglycylase.
ACOT9 protein networkhttps://string-db.org/network/9606.ENSP00000368605Acyl-coenzyme A thioesterase 9, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...]
VWA8 protein networkhttps://string-db.org/network/9606.ENSP00000368612Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro.
GATA3 protein networkhttps://string-db.org/network/9606.ENSP00000368632Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AG [...]
SLC23A2 protein networkhttps://string-db.org/network/9606.ENSP00000368637Solute carrier family 23 member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
C1orf159 protein networkhttps://string-db.org/network/9606.ENSP00000368644Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159.
PRDX4 protein networkhttps://string-db.org/network/9606.ENSP00000368646Peroxiredoxin-4; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...]
SLC30A6 protein networkhttps://string-db.org/network/9606.ENSP00000368648Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. Belongs to the cation diffusion facilitator [...]
RGCC protein networkhttps://string-db.org/network/9606.ENSP00000368664Regulator of cell cycle RGCC; Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells [...]
PTCHD1 protein networkhttps://string-db.org/network/9606.ENSP00000368666Patched domain-containing protein 1; Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, g [...]
DDX53 protein networkhttps://string-db.org/network/9606.ENSP00000368667Probable ATP-dependent RNA helicase DDX53; DEAD-box helicase 53.
AGRN protein networkhttps://string-db.org/network/9606.ENSP00000368678Agrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and dir [...]
PHEX protein networkhttps://string-db.org/network/9606.ENSP00000368682Phosphate-regulating neutral endopeptidase PHEX; Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological act [...]
EDN1 protein networkhttps://string-db.org/network/9606.ENSP00000368683Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 [...]
E2F4 protein networkhttps://string-db.org/network/9606.ENSP00000368686Transcription factor E2F4; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of gen [...]
LYRM7 protein networkhttps://string-db.org/network/9606.ENSP00000368688Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subuni [...]
HIVEP1 protein networkhttps://string-db.org/network/9606.ENSP00000368698Zinc finger protein 40; This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HI [...]
RASSF2 protein networkhttps://string-db.org/network/9606.ENSP00000368710Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting [...]
NAA16 protein networkhttps://string-db.org/network/9606.ENSP00000368716N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity.
PLEKHN1 protein networkhttps://string-db.org/network/9606.ENSP00000368720Pleckstrin homology domain-containing family N member 1; Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 [...]
XDH protein networkhttps://string-db.org/network/9606.ENSP00000368727Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generat [...]
TMEM170B protein networkhttps://string-db.org/network/9606.ENSP00000368737Transmembrane protein 170B; Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nuc [...]
CTXN3 protein networkhttps://string-db.org/network/9606.ENSP00000368758Cortexin-3; Cortexin 3.
NEDD9 protein networkhttps://string-db.org/network/9606.ENSP00000368759Enhancer of filamentation 1 p55; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control [...]
ADRA1D protein networkhttps://string-db.org/network/9606.ENSP00000368766Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Belongs to the G-protein coupled receptor 1 family. Adrenergic recept [...]
ASPH protein networkhttps://string-db.org/network/9606.ENSP00000368767Aspartyl/asparaginyl beta-hydroxylase; [Isoform 1]: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins; Belongs to the a [...]
MUC3A protein networkhttps://string-db.org/network/9606.ENSP00000368771Mucin-3A; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involve [...]
MTRF1 protein networkhttps://string-db.org/network/9606.ENSP00000368793Peptide chain release factor 1, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop [...]
KBTBD7 protein networkhttps://string-db.org/network/9606.ENSP00000368797Kelch repeat and BTB domain containing 7.
MBTPS2 protein networkhttps://string-db.org/network/9606.ENSP00000368798Membrane-bound transcription factor site-2 protease; Involved in regulated intramembrane proteolysis (RIP) that is the cleavage of membrane-spanning regulatory proteins by proteases within the pl [...]
KBTBD6 protein networkhttps://string-db.org/network/9606.ENSP00000368799Kelch repeat and BTB domain containing 6.
WBP4 protein networkhttps://string-db.org/network/9606.ENSP00000368801WW domain-binding protein 4; Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.
GCM2 protein networkhttps://string-db.org/network/9606.ENSP00000368805Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, ma [...]
SMPX protein networkhttps://string-db.org/network/9606.ENSP00000368808Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair.
KLHL34 protein networkhttps://string-db.org/network/9606.ENSP00000368813Kelch-like protein 34; Kelch like family member 34.
CMTM1 protein networkhttps://string-db.org/network/9606.ENSP00000368814CKLF like MARVEL transmembrane domain containing 1.
TOM1L2 protein networkhttps://string-db.org/network/9606.ENSP00000368818TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling.
CNKSR2 protein networkhttps://string-db.org/network/9606.ENSP00000368824Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways.
SNX2 protein networkhttps://string-db.org/network/9606.ENSP00000368831Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphat [...]
YPEL5 protein networkhttps://string-db.org/network/9606.ENSP00000368835Protein yippee-like 5; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation o [...]
NFX1 protein networkhttps://string-db.org/network/9606.ENSP00000368856Transcriptional repressor NF-X1; Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response b [...]
ELF2 protein networkhttps://string-db.org/network/9606.ENSP00000368868ETS-related transcription factor Elf-2; Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter.
INSC protein networkhttps://string-db.org/network/9606.ENSP00000368872Protein inscuteable homolog; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and di [...]
TOGARAM2 protein networkhttps://string-db.org/network/9606.ENSP00000368876TOG array regulator of axonemal microtubules 2.
FOXO1 protein networkhttps://string-db.org/network/9606.ENSP00000368880Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response eleme [...]
KIN protein networkhttps://string-db.org/network/9606.ENSP00000368881DNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and re [...]
RPS6KA3 protein networkhttps://string-db.org/network/9606.ENSP00000368884Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the [...]
PAK1IP1 protein networkhttps://string-db.org/network/9606.ENSP00000368887P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation [...]
LHFPL6 protein networkhttps://string-db.org/network/9606.ENSP00000368908LHFPL tetraspan subfamily member 6.
NHLRC3 protein networkhttps://string-db.org/network/9606.ENSP00000368920NHL repeat containing 3.
EIF1AX protein networkhttps://string-db.org/network/9606.ENSP00000368927Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding [...]
CCDC112 protein networkhttps://string-db.org/network/9606.ENSP00000368931Coiled-coil domain containing 112.
STOML3 protein networkhttps://string-db.org/network/9606.ENSP00000368952Stomatin-like protein 3; Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 fun [...]
REEP5 protein networkhttps://string-db.org/network/9606.ENSP00000368959Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family.
MAP7D2 protein networkhttps://string-db.org/network/9606.ENSP00000368964MAP7 domain containing 2.
HGSNAT protein networkhttps://string-db.org/network/9606.ENSP00000368965Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, conv [...]
TRPC3 protein networkhttps://string-db.org/network/9606.ENSP00000368966Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...]
UFM1 protein networkhttps://string-db.org/network/9606.ENSP00000368970Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer. The so-called ufmylation [...]
SLC35B3 protein networkhttps://string-db.org/network/9606.ENSP00000368981Adenosine 3'-phospho 5'-phosphosulfate transporter 2; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sul [...]
KATNB1 protein networkhttps://string-db.org/network/9606.ENSP00000368982Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of [...]
EXOSC9 protein networkhttps://string-db.org/network/9606.ENSP00000368984Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
OR6C65 protein networkhttps://string-db.org/network/9606.ENSP00000368986Olfactory receptor 6C65; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ARHGAP44 protein networkhttps://string-db.org/network/9606.ENSP00000368994Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-boun [...]
BCLAF3 protein networkhttps://string-db.org/network/9606.ENSP00000369009BCLAF1 and THRAP3 family member 3; Belongs to the BCLAF1/THRAP3 family.
NDNF protein networkhttps://string-db.org/network/9606.ENSP00000369014Protein NDNF; Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth. Promotes endothelial cell survival, vess [...]
INSL3 protein networkhttps://string-db.org/network/9606.ENSP00000369017Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insuli [...]
EEF1E1 protein networkhttps://string-db.org/network/9606.ENSP00000369038Eukaryotic translation elongation factor 1 epsilon-1; Positive modulator of ATM response to DNA damage.
IPO7 protein networkhttps://string-db.org/network/9606.ENSP00000369042Importin-7; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Actin [...]
SPINK4 protein networkhttps://string-db.org/network/9606.ENSP00000369045Serine peptidase inhibitor Kazal type 4.
B4GALT1 protein networkhttps://string-db.org/network/9606.ENSP00000369055Processed beta-1,4-galactosyltransferase 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-ty [...]
POSTN protein networkhttps://string-db.org/network/9606.ENSP00000369071Periostin; Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic acti [...]
CENPB protein networkhttps://string-db.org/network/9606.ENSP00000369075Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays [...]
SPEF1 protein networkhttps://string-db.org/network/9606.ENSP00000369080Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and sta [...]
TXNDC5 protein networkhttps://string-db.org/network/9606.ENSP00000369081Thioredoxin domain-containing protein 5; Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By sim [...]
ADPRM protein networkhttps://string-db.org/network/9606.ENSP00000369099Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. [...]
CSNK1A1L protein networkhttps://string-db.org/network/9606.ENSP00000369126Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large numbe [...]
DNAJA1 protein networkhttps://string-db.org/network/9606.ENSP00000369127DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transpo [...]
DSP protein networkhttps://string-db.org/network/9606.ENSP00000369129Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anch [...]
SIN3B protein networkhttps://string-db.org/network/9606.ENSP00000369131Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX he [...]
PDHA1 protein networkhttps://string-db.org/network/9606.ENSP00000369134Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereb [...]
MT1G protein networkhttps://string-db.org/network/9606.ENSP00000369139Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
APTX protein networkhttps://string-db.org/network/9606.ENSP00000369145Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at b [...]
MT1M protein networkhttps://string-db.org/network/9606.ENSP00000369146Metallothionein-1M; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
SMAD9 protein networkhttps://string-db.org/network/9606.ENSP00000369154Mothers against decapentaplegic homolog 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor- regulated SMAD (R-SMAD); Belongs t [...]
OR10A4 protein networkhttps://string-db.org/network/9606.ENSP00000369157Olfactory receptor 10A4; Odorant receptor (Potential). May be involved in taste perception.
RIOK1 protein networkhttps://string-db.org/network/9606.ENSP00000369162Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required [...]
NDUFB6 protein networkhttps://string-db.org/network/9606.ENSP00000369176NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
NRBP1 protein networkhttps://string-db.org/network/9606.ENSP00000369192Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the N [...]
ADGRG2 protein networkhttps://string-db.org/network/9606.ENSP00000369198Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within [...]
SOHLH2 protein networkhttps://string-db.org/network/9606.ENSP00000369210Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermat [...]
DDX58 protein networkhttps://string-db.org/network/9606.ENSP00000369213Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type [...]
ARIH1 protein networkhttps://string-db.org/network/9606.ENSP00000369217E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiq [...]
ADAM32 protein networkhttps://string-db.org/network/9606.ENSP00000369238Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.
MAB21L1 protein networkhttps://string-db.org/network/9606.ENSP00000369251Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye. It is unclear whether it di [...]
CNGA4 protein networkhttps://string-db.org/network/9606.ENSP00000369268Cyclic nucleotide-gated cation channel alpha-4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory [...]
RREB1 protein networkhttps://string-db.org/network/9606.ENSP00000369270Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differenti [...]
PHKA2 protein networkhttps://string-db.org/network/9606.ENSP00000369274Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bin [...]
LY86 protein networkhttps://string-db.org/network/9606.ENSP00000369286Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell su [...]
LETM2 protein networkhttps://string-db.org/network/9606.ENSP00000369291LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2.
SAMD9 protein networkhttps://string-db.org/network/9606.ENSP00000369292Sterile alpha motif domain-containing protein 9; May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF [...]
IL2RA protein networkhttps://string-db.org/network/9606.ENSP00000369293Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress [...]
TRIM22 protein networkhttps://string-db.org/network/9606.ENSP00000369299E3 ubiquitin-protein ligase TRIM22; Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22- dependent ubiquitination of [...]
GLRX protein networkhttps://string-db.org/network/9606.ENSP00000369314Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutar [...]
KRT6A protein networkhttps://string-db.org/network/9606.ENSP00000369317Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a majo [...]
RHOBTB3 protein networkhttps://string-db.org/network/9606.ENSP00000369318Rho-related BTB domain-containing protein 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating [...]
RS1 protein networkhttps://string-db.org/network/9606.ENSP00000369320Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homom [...]
CDKL5 protein networkhttps://string-db.org/network/9606.ENSP00000369325Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2. May regulate ciliogenesis.
LINGO2 protein networkhttps://string-db.org/network/9606.ENSP00000369328Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine rich repeat and Ig domain containing 2.
FBH1 protein networkhttps://string-db.org/network/9606.ENSP00000369335F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. I [...]
GPR150 protein networkhttps://string-db.org/network/9606.ENSP00000369344Probable G-protein coupled receptor 150; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
ARSK protein networkhttps://string-db.org/network/9606.ENSP00000369346Arylsulfatase family member K.
KRT81 protein networkhttps://string-db.org/network/9606.ENSP00000369349Keratin, type II cuticular Hb1; Keratin 81.
EQTN protein networkhttps://string-db.org/network/9606.ENSP00000369371Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis.
BEND2 protein networkhttps://string-db.org/network/9606.ENSP00000369372BEN domain containing 2.
TRIM5 protein networkhttps://string-db.org/network/9606.ENSP00000369373Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral [...]
TEK protein networkhttps://string-db.org/network/9606.ENSP00000369375Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, [...]
SCML1 protein networkhttps://string-db.org/network/9606.ENSP00000369380Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...]
MPV17 protein networkhttps://string-db.org/network/9606.ENSP00000369383Protein Mpv17; Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis. Involved in mitochondrial de [...]
CDK14 protein networkhttps://string-db.org/network/9606.ENSP00000369390Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regula [...]
RPP40 protein networkhttps://string-db.org/network/9606.ENSP00000369391Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclea [...]
LRRC19 protein networkhttps://string-db.org/network/9606.ENSP00000369395Leucine-rich repeat-containing protein 19; Leucine rich repeat containing 19.
SLC4A11 protein networkhttps://string-db.org/network/9606.ENSP00000369399Sodium bicarbonate transporter-like protein 11; Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the corn [...]
NHS protein networkhttps://string-db.org/network/9606.ENSP00000369400Nance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, [...]
EXOC3L4 protein networkhttps://string-db.org/network/9606.ENSP00000369409Exocyst complex component 3 like 4; Belongs to the SEC6 family.
RFC3 protein networkhttps://string-db.org/network/9606.ENSP00000369411Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...]
STEAP4 protein networkhttps://string-db.org/network/9606.ENSP00000369419Metalloreductase STEAP4; Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound o [...]
RBBP7 protein networkhttps://string-db.org/network/9606.ENSP00000369424Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a mann [...]
CAAP1 protein networkhttps://string-db.org/network/9606.ENSP00000369431Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.
ANKRD16 protein networkhttps://string-db.org/network/9606.ENSP00000369436Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role i [...]
KRTAP10-10 protein networkhttps://string-db.org/network/9606.ENSP00000369438Keratin-associated protein 10-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), whic [...]
TRIM6 protein networkhttps://string-db.org/network/9606.ENSP00000369440Tripartite motif-containing protein 6; E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells [...]
KL protein networkhttps://string-db.org/network/9606.ENSP00000369442Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as [...]
ELAVL2 protein networkhttps://string-db.org/network/9606.ENSP00000369453ELAV-like protein 2; RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'U [...]
ITPA protein networkhttps://string-db.org/network/9606.ENSP00000369456Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hyd [...]
ECI2 protein networkhttps://string-db.org/network/9606.ENSP00000369461Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (B [...]
TXLNG protein networkhttps://string-db.org/network/9606.ENSP00000369465Gamma-taxilin; May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involv [...]
N4BP2L1 protein networkhttps://string-db.org/network/9606.ENSP00000369473NEDD4 binding protein 2 like 1.
BRCA2 protein networkhttps://string-db.org/network/9606.ENSP00000369497Breast cancer type 2 susceptibility protein; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly o [...]
SYAP1 protein networkhttps://string-db.org/network/9606.ENSP00000369500Synapse-associated protein 1; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation.
ALOX15B protein networkhttps://string-db.org/network/9606.ENSP00000369530Arachidonate 15-lipoxygenase B; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bi [...]
UBQLNL protein networkhttps://string-db.org/network/9606.ENSP00000369531Ubiquilin-like protein; Ubiquilin like.
GDI2 protein networkhttps://string-db.org/network/9606.ENSP00000369538Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
NABP2 protein networkhttps://string-db.org/network/9606.ENSP00000369545SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as [...]
S100G protein networkhttps://string-db.org/network/9606.ENSP00000369547S100 calcium binding protein G; Belongs to the S-100 family.
IFNA8 protein networkhttps://string-db.org/network/9606.ENSP00000369553Interferon alpha-8; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...]
IFNA2 protein networkhttps://string-db.org/network/9606.ENSP00000369554Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities.
IFNA6 protein networkhttps://string-db.org/network/9606.ENSP00000369558Interferon alpha-6; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...]
OR51I1 protein networkhttps://string-db.org/network/9606.ENSP00000369559Olfactory receptor 51I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IFNA16 protein networkhttps://string-db.org/network/9606.ENSP00000369564Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs [...]
IFNA10 protein networkhttps://string-db.org/network/9606.ENSP00000369566Interferon alpha-10; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs [...]
OR51B6 protein networkhttps://string-db.org/network/9606.ENSP00000369568Olfactory receptor 51B6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IFNA14 protein networkhttps://string-db.org/network/9606.ENSP00000369571Interferon alpha-14; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs [...]
OR51B4 protein networkhttps://string-db.org/network/9606.ENSP00000369573Olfactory receptor 51B4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IFNA21 protein networkhttps://string-db.org/network/9606.ENSP00000369574Interferon alpha-21; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs [...]
IFNW1 protein networkhttps://string-db.org/network/9606.ENSP00000369578Interferon omega 1.
IFNB1 protein networkhttps://string-db.org/network/9606.ENSP00000369581Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family.
CCDC85C protein networkhttps://string-db.org/network/9606.ENSP00000369592Coiled-coil domain-containing protein 85C; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). May play a [...]
FOCAD protein networkhttps://string-db.org/network/9606.ENSP00000369599Focadhesin; Potential tumor suppressor in gliomas.
FBXO16 protein networkhttps://string-db.org/network/9606.ENSP00000369604F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
SPZ1 protein networkhttps://string-db.org/network/9606.ENSP00000369611Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell prolifer [...]
CNTROB protein networkhttps://string-db.org/network/9606.ENSP00000369614Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
FASTKD5 protein networkhttps://string-db.org/network/9606.ENSP00000369618FAST kinase domain-containing protein 5, mitochondrial; Plays an important role in the processing of non-canonical mitochondrial mRNA precursors.
FAM50B protein networkhttps://string-db.org/network/9606.ENSP00000369627Protein FAM50B; Family with sequence similarity 50 member B.
PXDC1 protein networkhttps://string-db.org/network/9606.ENSP00000369636PX domain containing 1.
GRPR protein networkhttps://string-db.org/network/9606.ENSP00000369643Gastrin-releasing peptide receptor; Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, res [...]
AVP protein networkhttps://string-db.org/network/9606.ENSP00000369647Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin.
FBXL19 protein networkhttps://string-db.org/network/9606.ENSP00000369666F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-p [...]
BCL7C protein networkhttps://string-db.org/network/9606.ENSP00000369674B-cell CLL/lymphoma 7 protein family member C; May play an anti-apoptotic role.
EMILIN1 protein networkhttps://string-db.org/network/9606.ENSP00000369677EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vesse [...]
USP3 protein networkhttps://string-db.org/network/9606.ENSP00000369681Ubiquitin carboxyl-terminal hydrolase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subseque [...]
MRPS26 protein networkhttps://string-db.org/network/9606.ENSP00000369682Mitochondrial ribosomal protein S26; Belongs to the mitochondrion-specific ribosomal protein mS26 family.
CALML5 protein networkhttps://string-db.org/network/9606.ENSP00000369689Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes.
MLLT3 protein networkhttps://string-db.org/network/9606.ENSP00000369695Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausi [...]
CLTRN protein networkhttps://string-db.org/network/9606.ENSP00000369699Collectrin; Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their [...]
LHFPL2 protein networkhttps://string-db.org/network/9606.ENSP00000369702LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development.
TUBB2A protein networkhttps://string-db.org/network/9606.ENSP00000369703Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...]
CHD3 protein networkhttps://string-db.org/network/9606.ENSP00000369716Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring [...]
OR52A1 protein networkhttps://string-db.org/network/9606.ENSP00000369725Olfactory receptor 52A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52J3 protein networkhttps://string-db.org/network/9606.ENSP00000369728Olfactory receptor 52J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51A2 protein networkhttps://string-db.org/network/9606.ENSP00000369729Olfactory receptor 51A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51T1 protein networkhttps://string-db.org/network/9606.ENSP00000369738Olfactory receptor 51T1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
BPHL protein networkhttps://string-db.org/network/9606.ENSP00000369739Valacyclovir hydrolase; Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovi [...]
OR51F1 protein networkhttps://string-db.org/network/9606.ENSP00000369744Olfactory receptor 51F1; Odorant receptor.
MMP26 protein networkhttps://string-db.org/network/9606.ENSP00000369753Matrix metalloproteinase-26; May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B; Belon [...]
C2CD4B protein networkhttps://string-db.org/network/9606.ENSP00000369755C2 calcium-dependent domain-containing protein 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family.
PTPRA protein networkhttps://string-db.org/network/9606.ENSP00000369756Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation (By similarity). Following integrin engagement, spe [...]
RPS6 protein networkhttps://string-db.org/network/9606.ENSP0000036975740S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; Belongs to the eukaryotic riboso [...]
ZNF763 protein networkhttps://string-db.org/network/9606.ENSP00000369774Zinc finger protein 763.
ZNF768 protein networkhttps://string-db.org/network/9606.ENSP00000369777Zinc finger protein 768; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TUBAL3 protein networkhttps://string-db.org/network/9606.ENSP00000369784Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the al [...]
PIR protein networkhttps://string-db.org/network/9606.ENSP00000369786Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient termina [...]
UCN3 protein networkhttps://string-db.org/network/9606.ENSP00000369798Urocortin-3; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
VPS16 protein networkhttps://string-db.org/network/9606.ENSP00000369810Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...]
AKR1C4 protein networkhttps://string-db.org/network/9606.ENSP00000369814Aldo-keto reductase family 1 member C4; Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan- 3-alpha,17-beta-diol (3-alpha-d [...]
SHBG protein networkhttps://string-db.org/network/9606.ENSP00000369816Sex hormone-binding globulin; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-d [...]
PIGA protein networkhttps://string-db.org/network/9606.ENSP00000369820Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis; [...]
NQO2 protein networkhttps://string-db.org/network/9606.ENSP00000369822Ribosyldihydronicotinamide dehydrogenase [quinone]; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathwa [...]
TEX26 protein networkhttps://string-db.org/network/9606.ENSP00000369840Testis-expressed protein 26; Testis expressed 26.
MEDAG protein networkhttps://string-db.org/network/9606.ENSP00000369849Mesenteric estrogen-dependent adipogenesis protein; Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes.
C2CD2 protein networkhttps://string-db.org/network/9606.ENSP00000369853C2 calcium dependent domain containing 2.
ASB9 protein networkhttps://string-db.org/network/9606.ENSP00000369855Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination a [...]
ABRAXAS1 protein networkhttps://string-db.org/network/9606.ENSP00000369857BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the [...]
MOSPD2 protein networkhttps://string-db.org/network/9606.ENSP00000369860Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
TLCD3B protein networkhttps://string-db.org/network/9606.ENSP00000369863Ceramide synthase; Involved in ceramide synthesis.
HAUS6 protein networkhttps://string-db.org/network/9606.ENSP00000369871HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes th [...]
SLTM protein networkhttps://string-db.org/network/9606.ENSP00000369887SAFB-like transcription modulator; When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis.
COL2A1 protein networkhttps://string-db.org/network/9606.ENSP00000369889Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of [...]
GEMIN8 protein networkhttps://string-db.org/network/9606.ENSP00000369895Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...]
CARS1 protein networkhttps://string-db.org/network/9606.ENSP00000369897Cysteine--tRNA ligase, cytoplasmic; cysteinyl-tRNA synthetase 1.
RRAGA protein networkhttps://string-db.org/network/9606.ENSP00000369899Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling casc [...]
SAXO1 protein networkhttps://string-db.org/network/9606.ENSP00000369907Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature. Belongs to the FAM154 family.
NAP1L4 protein networkhttps://string-db.org/network/9606.ENSP00000369915Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. Belongs to the nucleosome assembly protein (NAP) family.
ADAMTSL1 protein networkhttps://string-db.org/network/9606.ENSP00000369921ADAMTS-like protein 1; ADAMTS like 1.
AKR1C3 protein networkhttps://string-db.org/network/9606.ENSP00000369927Aldo-keto reductase family 1 member C3; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the [...]
SLC22A18 protein networkhttps://string-db.org/network/9606.ENSP00000369948Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related [...]
ADRA1A protein networkhttps://string-db.org/network/9606.ENSP00000369960Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect i [...]
IGSF5 protein networkhttps://string-db.org/network/9606.ENSP00000369962Immunoglobulin superfamily member 5; Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithel [...]
C20orf141 protein networkhttps://string-db.org/network/9606.ENSP00000369963Uncharacterized protein C20orf141; Chromosome 20 open reading frame 141.
BTF3 protein networkhttps://string-db.org/network/9606.ENSP00000369965Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they [...]
EGFL6 protein networkhttps://string-db.org/network/9606.ENSP00000369976Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity). Belongs to the nephronectin fami [...]
CPXM1 protein networkhttps://string-db.org/network/9606.ENSP00000369979Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).
SH3GL2 protein networkhttps://string-db.org/network/9606.ENSP00000369981Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to m [...]
KATNAL1 protein networkhttps://string-db.org/network/9606.ENSP00000369989Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-d [...]
ATXN3L protein networkhttps://string-db.org/network/9606.ENSP00000369996Ataxin-3-like protein; Deubiquitinating enzyme that cleaves both 'Lys-48'-linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).
BNIP3L protein networkhttps://string-db.org/network/9606.ENSP00000370003BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti- apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, althou [...]
TMSB4X protein networkhttps://string-db.org/network/9606.ENSP00000370010Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits a [...]
PTCD2 protein networkhttps://string-db.org/network/9606.ENSP00000370013Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function.
CNTLN protein networkhttps://string-db.org/network/9606.ENSP00000370021Centlein; Required for centrosome cohesion and recruitment of CEP68 to centrosomes.
EBF4 protein networkhttps://string-db.org/network/9606.ENSP00000370022Transcription factor COE4; Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'; Belongs to the COE family.
HADHA protein networkhttps://string-db.org/network/9606.ENSP00000370023Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial [...]
TLR7 protein networkhttps://string-db.org/network/9606.ENSP00000370034Toll-like receptor 7; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific [...]
BNC2 protein networkhttps://string-db.org/network/9606.ENSP00000370047Zinc finger protein basonuclin-2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes.
UBL3 protein networkhttps://string-db.org/network/9606.ENSP00000370055Ubiquitin-like protein 3; Ubiquitin like 3.
FRMPD4 protein networkhttps://string-db.org/network/9606.ENSP00000370057FERM and PDZ domain-containing protein 4; Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinos [...]
SERPINB9 protein networkhttps://string-db.org/network/9606.ENSP00000370074Serpin B9; Granzyme B inhibitor.
CCDC171 protein networkhttps://string-db.org/network/9606.ENSP00000370077Coiled-coil domain containing 171.
PDE4A protein networkhttps://string-db.org/network/9606.ENSP00000370078cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
SMN1 protein networkhttps://string-db.org/network/9606.ENSP00000370083Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an import [...]
AMELX protein networkhttps://string-db.org/network/9606.ENSP00000370088Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in t [...]
PSIP1 protein networkhttps://string-db.org/network/9606.ENSP00000370114PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulati [...]
SERPINB1 protein networkhttps://string-db.org/network/9606.ENSP00000370115Leukocyte elastase inhibitor; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primar [...]
SMN2 protein networkhttps://string-db.org/network/9606.ENSP00000370119Survival of motor neuron 2, centromeric.
HMGN1 protein networkhttps://string-db.org/network/9606.ENSP00000370125Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which [...]
SERF1B protein networkhttps://string-db.org/network/9606.ENSP00000370126Small EDRK-rich factor 1B.
SLC7A1 protein networkhttps://string-db.org/network/9606.ENSP00000370128High affinity cationic amino acid transporter 1; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues [...]
AKR1C2 protein networkhttps://string-db.org/network/9606.ENSP00000370129Aldo-keto reductase family 1 member C2; Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5- beta-tetrahydrosteroids. Ca [...]
HCCS protein networkhttps://string-db.org/network/9606.ENSP00000370139Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.
WRNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000370150ATPase WRNIP1; Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediat [...]
TAF9 protein networkhttps://string-db.org/network/9606.ENSP00000370193Transcription initiation factor TFIID subunit 9; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of [...]
GMDS protein networkhttps://string-db.org/network/9606.ENSP00000370194GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydrata [...]
SBF1 protein networkhttps://string-db.org/network/9606.ENSP00000370196Myotubularin-related protein 5; Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (G [...]
SNAPC3 protein networkhttps://string-db.org/network/9606.ENSP00000370200snRNA-activating protein complex subunit 3; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...]
AK6 protein networkhttps://string-db.org/network/9606.ENSP00000370201Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and m [...]
RABGEF1 protein networkhttps://string-db.org/network/9606.ENSP00000370208Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. S [...]
CLCN4 protein networkhttps://string-db.org/network/9606.ENSP00000370213H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Belongs to the chloride channel (TC 2.A.49) famil [...]
CENPO protein networkhttps://string-db.org/network/9606.ENSP00000370214Centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
NOXRED1 protein networkhttps://string-db.org/network/9606.ENSP00000370215NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase.
POMP protein networkhttps://string-db.org/network/9606.ENSP00000370222Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the assoc [...]
PARM1 protein networkhttps://string-db.org/network/9606.ENSP00000370224Prostate androgen-regulated mucin-like protein 1; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.
WWC3 protein networkhttps://string-db.org/network/9606.ENSP00000370242Protein WWC3; WWC family member 3.
NKX3-1 protein networkhttps://string-db.org/network/9606.ENSP00000370253Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal [...]
AKR1C1 protein networkhttps://string-db.org/network/9606.ENSP00000370254Aldo-keto reductase family 1 member C1; Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of [...]
EIF3CL protein networkhttps://string-db.org/network/9606.ENSP00000370258Eukaryotic translation initiation factor 3 subunit C-like protein; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiati [...]
ESRRB protein networkhttps://string-db.org/network/9606.ENSP00000370270Steroid hormone receptor ERR2; [Isoform 3]: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regula [...]
SELENOO protein networkhttps://string-db.org/network/9606.ENSP00000370288Protein adenylyltransferase SelO, mitochondrial; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mit [...]
HUS1B protein networkhttps://string-db.org/network/9606.ENSP00000370293Checkpoint protein HUS1B; HUS1 checkpoint clamp component B; Belongs to the HUS1 family.
CER1 protein networkhttps://string-db.org/network/9606.ENSP00000370297Cerberus; Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP- inhibitory mechanism. Can regulate Nodal signaling during gas [...]
SHROOM2 protein networkhttps://string-db.org/network/9606.ENSP00000370299Protein Shroom2; May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their asso [...]
ZDHHC21 protein networkhttps://string-db.org/network/9606.ENSP00000370303Palmitoyltransferase ZDHHC21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular [...]
CEP152 protein networkhttps://string-db.org/network/9606.ENSP00000370337Centrosomal protein of 152 kDa; Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recr [...]
NFIB protein networkhttps://string-db.org/network/9606.ENSP00000370340Nuclear factor 1 B-type; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellul [...]
IRF4 protein networkhttps://string-db.org/network/9606.ENSP00000370343Interferon regulatory factor 4; Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enha [...]
PAN3 protein networkhttps://string-db.org/network/9606.ENSP00000370345PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediat [...]
NLN protein networkhttps://string-db.org/network/9606.ENSP00000370372Neurolysin, mitochondrial; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A; Belongs to the peptidase M3 family.
FKBP1B protein networkhttps://string-db.org/network/9606.ENSP00000370373Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catal [...]
DUT protein networkhttps://string-db.org/network/9606.ENSP00000370376Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decrea [...]
PITRM1 protein networkhttps://string-db.org/network/9606.ENSP00000370377Presequence protease, mitochondrial; Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent [...]
RUFY3 protein networkhttps://string-db.org/network/9606.ENSP00000370394Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). M [...]
SGTB protein networkhttps://string-db.org/network/9606.ENSP00000370395Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
CDX2 protein networkhttps://string-db.org/network/9606.ENSP00000370408Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to ma [...]
TTC38 protein networkhttps://string-db.org/network/9606.ENSP00000370419Tetratricopeptide repeat domain 38; Belongs to the TTC38 family.
VCX3B protein networkhttps://string-db.org/network/9606.ENSP00000370420Variable charge X-linked protein 3B; May mediate a process in spermatogenesis or may play a role in sex ratio distortion.
PDX1 protein networkhttps://string-db.org/network/9606.ENSP00000370421Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-d [...]
PNPLA4 protein networkhttps://string-db.org/network/9606.ENSP00000370430Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase.
ADAMTS6 protein networkhttps://string-db.org/network/9606.ENSP00000370443ADAM metallopeptidase with thrombospondin type 1 motif 6.
VCX protein networkhttps://string-db.org/network/9606.ENSP00000370447Variable charge X-linked protein 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family.
CWC27 protein networkhttps://string-db.org/network/9606.ENSP00000370460Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.
IGFBP3 protein networkhttps://string-db.org/network/9606.ENSP00000370473Insulin-like growth factor-binding protein 3; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...]
VCX3A protein networkhttps://string-db.org/network/9606.ENSP00000370479Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Belongs to the VCX/VCY family.
NLGN4X protein networkhttps://string-db.org/network/9606.ENSP00000370483Neuroligin-4, X-linked; Putative neuronal cell surface protein involved in cell-cell- interactions; Belongs to the type-B carboxylesterase/lipase family.
CCM2 protein networkhttps://string-db.org/network/9606.ENSP00000370503Cerebral cavernous malformations 2 protein; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of e [...]
MTIF3 protein networkhttps://string-db.org/network/9606.ENSP00000370508Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subu [...]
PFKP protein networkhttps://string-db.org/network/9606.ENSP00000370517ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs t [...]
ARSF protein networkhttps://string-db.org/network/9606.ENSP00000370519Arylsulfatase F.
AIPL1 protein networkhttps://string-db.org/network/9606.ENSP00000370521Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization.
ARSH protein networkhttps://string-db.org/network/9606.ENSP00000370522Arylsulfatase family member H.
RCAN1 protein networkhttps://string-db.org/network/9606.ENSP00000370527Calcipressin-1; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By simil [...]
ACOT6 protein networkhttps://string-db.org/network/9606.ENSP00000370531Putative acyl-coenzyme A thioesterase 6; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the poten [...]
GTF3A protein networkhttps://string-db.org/network/9606.ENSP00000370532Transcription factor IIIA; Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their [...]
SDC1 protein networkhttps://string-db.org/network/9606.ENSP00000370542Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert w [...]
SLC5A3 protein networkhttps://string-db.org/network/9606.ENSP00000370543Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Belongs to the sodium:s [...]
ARSD protein networkhttps://string-db.org/network/9606.ENSP00000370546Arylsulfatase D.
GYG2 protein networkhttps://string-db.org/network/9606.ENSP00000370555Glycogenin-2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Belongs to the glycosyltransferase 8 family. Gly [...]
MIS12 protein networkhttps://string-db.org/network/9606.ENSP00000370557Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore m [...]
SHISAL1 protein networkhttps://string-db.org/network/9606.ENSP00000370568Protein shisa-like-1; Shisa like 1.
TH protein networkhttps://string-db.org/network/9606.ENSP00000370571Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons.
CD99 protein networkhttps://string-db.org/network/9606.ENSP00000370588CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome t [...]
NOP56 protein networkhttps://string-db.org/network/9606.ENSP00000370589Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the [...]
PTPRD protein networkhttps://string-db.org/network/9606.ENSP00000370593Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically [...]
TECRL protein networkhttps://string-db.org/network/9606.ENSP00000370607trans-2,3-enoyl-CoA reductase like.
ZBED1 protein networkhttps://string-db.org/network/9606.ENSP00000370621Zinc finger BED domain-containing protein 1; Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 [...]
MIER3 protein networkhttps://string-db.org/network/9606.ENSP00000370624Mesoderm induction early response protein 3; Transcriptional repressor.
POLR2B protein networkhttps://string-db.org/network/9606.ENSP00000370625DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest com [...]
SLC39A14 protein networkhttps://string-db.org/network/9606.ENSP00000370635Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron.
ASMT protein networkhttps://string-db.org/network/9606.ENSP00000370639Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack e [...]
RDH14 protein networkhttps://string-db.org/network/9606.ENSP00000370648Retinol dehydrogenase 14; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-ret [...]
GEN1 protein networkhttps://string-db.org/network/9606.ENSP00000370653Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex product [...]
SLC8A3 protein networkhttps://string-db.org/network/9606.ENSP00000370669Sodium/calcium exchanger 3; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca [...]
KLHL42 protein networkhttps://string-db.org/network/9606.ENSP00000370671Kelch-like protein 42; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligas [...]
MANSC4 protein networkhttps://string-db.org/network/9606.ENSP00000370673MANSC domain containing 4.
EXOC1 protein networkhttps://string-db.org/network/9606.ENSP00000370695Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
P2RY8 protein networkhttps://string-db.org/network/9606.ENSP00000370697P2Y purinoceptor 8; Probable receptor for purines coupled to G-proteins.
IL6ST protein networkhttps://string-db.org/network/9606.ENSP00000370698Interleukin-6 receptor subunit beta; Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding o [...]
KDM4C protein networkhttps://string-db.org/network/9606.ENSP00000370710Lysine-specific demethylase 4C; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylat [...]
ADARB2 protein networkhttps://string-db.org/network/9606.ENSP00000370713Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of bindi [...]
ASMTL protein networkhttps://string-db.org/network/9606.ENSP00000370718Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides [...]
ITSN1 protein networkhttps://string-db.org/network/9606.ENSP00000370719Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereb [...]
FAM49A protein networkhttps://string-db.org/network/9606.ENSP00000370724Protein FAM49A; Belongs to the FAM49 family.
TMEM165 protein networkhttps://string-db.org/network/9606.ENSP00000370736Transmembrane protein 165; May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.
GLDC protein networkhttps://string-db.org/network/9606.ENSP00000370737Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its p [...]
ITPR2 protein networkhttps://string-db.org/network/9606.ENSP00000370744Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP b [...]
DDX1 protein networkhttps://string-db.org/network/9606.ENSP00000370745ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses AT [...]
IDI1 protein networkhttps://string-db.org/network/9606.ENSP00000370748Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosp [...]
RDH11 protein networkhttps://string-db.org/network/9606.ENSP00000370750Retinol dehydrogenase 11; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol. Exh [...]
GP2 protein networkhttps://string-db.org/network/9606.ENSP00000370767Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2.
C17orf107 protein networkhttps://string-db.org/network/9606.ENSP00000370770Uncharacterized protein C17orf107; Chromosome 17 open reading frame 107.
CDC20B protein networkhttps://string-db.org/network/9606.ENSP00000370781Cell division cycle 20B; Belongs to the WD repeat CDC20/Fizzy family.
MBD3L2 protein networkhttps://string-db.org/network/9606.ENSP00000370800methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family.
MBD3L4 protein networkhttps://string-db.org/network/9606.ENSP00000370801methyl-CpG binding domain protein 3 like 4.
CCP110 protein networkhttps://string-db.org/network/9606.ENSP00000370803Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration wi [...]
SLC25A6 protein networkhttps://string-db.org/network/9606.ENSP00000370808ADP/ATP translocase 3, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the pe [...]
ESM1 protein networkhttps://string-db.org/network/9606.ENSP00000370812Endothelial cell-specific molecule 1; Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.
HR protein networkhttps://string-db.org/network/9606.ENSP00000370826Lysine-specific demethylase hairless; Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair b [...]
SGCB protein networkhttps://string-db.org/network/9606.ENSP00000370839Beta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
IL33 protein networkhttps://string-db.org/network/9606.ENSP00000370842Interleukin-33 (109-270); Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the matura [...]
ITPRIPL2 protein networkhttps://string-db.org/network/9606.ENSP00000370849Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2.
TGM3 protein networkhttps://string-db.org/network/9606.ENSP00000370867Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various prot [...]
OCIAD1 protein networkhttps://string-db.org/network/9606.ENSP00000370882OCIA domain-containing protein 1; Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing [...]
MLANA protein networkhttps://string-db.org/network/9606.ENSP00000370886Melanoma antigen recognized by T-cells 1; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of me [...]
DENND1C protein networkhttps://string-db.org/network/9606.ENSP00000370889DENN domain-containing protein 1C; Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab prote [...]
STK35 protein networkhttps://string-db.org/network/9606.ENSP00000370891Serine/threonine kinase 35.
GREB1 protein networkhttps://string-db.org/network/9606.ENSP00000370896Protein GREB1; May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.
TEC protein networkhttps://string-db.org/network/9606.ENSP00000370912Tyrosine-protein kinase Tec; Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regu [...]
E2F6 protein networkhttps://string-db.org/network/9606.ENSP00000370936Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'- TTTC[CG]CGC-3'. Has a preference for the 5'-TTTC [...]
CDK8 protein networkhttps://string-db.org/network/9606.ENSP00000370938Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridg [...]
NPSR1 protein networkhttps://string-db.org/network/9606.ENSP00000370950Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pa [...]
GGT6 protein networkhttps://string-db.org/network/9606.ENSP00000370962Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family.
CRYZL1 protein networkhttps://string-db.org/network/9606.ENSP00000370966Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
MYBBP1A protein networkhttps://string-db.org/network/9606.ENSP00000370968Myb-binding protein 1A; May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone [...]
TNNT3 protein networkhttps://string-db.org/network/9606.ENSP00000370975Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin A [...]
CRLF2 protein networkhttps://string-db.org/network/9606.ENSP00000370978Cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activat [...]
ENSP00000370980 protein networkhttps://string-db.org/network/9606.ENSP00000370980Novel protein.
LZTS1 protein networkhttps://string-db.org/network/9606.ENSP00000370981Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle a [...]
COMMD8 protein networkhttps://string-db.org/network/9606.ENSP00000370984COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B.
CD274 protein networkhttps://string-db.org/network/9606.ENSP00000370989Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation thre [...]
SHOX protein networkhttps://string-db.org/network/9606.ENSP00000370990Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily.
C2orf50 protein networkhttps://string-db.org/network/9606.ENSP00000370997Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50.
RNF6 protein networkhttps://string-db.org/network/9606.ENSP00000371000E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regu [...]
ZMYND11 protein networkhttps://string-db.org/network/9606.ENSP00000371003Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongati [...]
SIRPB1 protein networkhttps://string-db.org/network/9606.ENSP00000371018Signal-regulatory protein beta-1; Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the r [...]
SIRPD protein networkhttps://string-db.org/network/9606.ENSP00000371036Signal regulatory protein delta.
CATSPERD protein networkhttps://string-db.org/network/9606.ENSP00000371037Cation channel sperm-associated protein subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm [...]
RLN2 protein networkhttps://string-db.org/network/9606.ENSP00000371040Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnan [...]
ZZEF1 protein networkhttps://string-db.org/network/9606.ENSP00000371051Zinc finger ZZ-type and EF-hand domain containing 1.
INSL6 protein networkhttps://string-db.org/network/9606.ENSP00000371054Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization.
C5orf51 protein networkhttps://string-db.org/network/9606.ENSP00000371061UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family.
JAK2 protein networkhttps://string-db.org/network/9606.ENSP00000371067Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling e [...]
ATP8A2 protein networkhttps://string-db.org/network/9606.ENSP00000371070Phospholipid-transporting ATPase IB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
PLCXD1 protein networkhttps://string-db.org/network/9606.ENSP00000371073PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1.
ATP8A1 protein networkhttps://string-db.org/network/9606.ENSP00000371084Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
BAIAP2L2 protein networkhttps://string-db.org/network/9606.ENSP00000371085Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to [...]
NOL10 protein networkhttps://string-db.org/network/9606.ENSP00000371101Nucleolar protein 10; Belongs to the WD repeat NOL10/ENP2 family.
GCAT protein networkhttps://string-db.org/network/9606.ENSP000003711102-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Glycine C-acetyltransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
NUTM2D protein networkhttps://string-db.org/network/9606.ENSP00000371116NUT family member 2D; Belongs to the NUT family.
GAGE12E protein networkhttps://string-db.org/network/9606.ENSP00000371117G antigen 12E; Belongs to the GAGE family.
NUTM2A protein networkhttps://string-db.org/network/9606.ENSP00000371126NUT family member 2A.
HMG20A protein networkhttps://string-db.org/network/9606.ENSP00000371133High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer [...]
GAGE12H protein networkhttps://string-db.org/network/9606.ENSP00000371141G antigen 12H.
ASAH1 protein networkhttps://string-db.org/network/9606.ENSP00000371152Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form [...]
NUP58 protein networkhttps://string-db.org/network/9606.ENSP00000371155Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Belongs to the NUP58 family.
RCL1 protein networkhttps://string-db.org/network/9606.ENSP00000371169RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 tha [...]
GGA1 protein networkhttps://string-db.org/network/9606.ENSP00000371175ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathr [...]
CATSPER2 protein networkhttps://string-db.org/network/9606.ENSP00000371180Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...]
CAMKK1 protein networkhttps://string-db.org/network/9606.ENSP00000371188Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular p [...]
CPPED1 protein networkhttps://string-db.org/network/9606.ENSP00000371193Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. M [...]
LSP1 protein networkhttps://string-db.org/network/9606.ENSP00000371194Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis.
ARRDC5 protein networkhttps://string-db.org/network/9606.ENSP00000371200Arrestin domain containing 5; Belongs to the arrestin family.
NSUN7 protein networkhttps://string-db.org/network/9606.ENSP00000371201Putative methyltransferase NSUN7; May have S-adenosyl-L-methionine-dependent methyl-transferase activity; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
RHOH protein networkhttps://string-db.org/network/9606.ENSP00000371219Rho-related GTP-binding protein RhoH; Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen rec [...]
MTMR6 protein networkhttps://string-db.org/network/9606.ENSP00000371221Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisph [...]
AK3 protein networkhttps://string-db.org/network/9606.ENSP00000371230GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotrans [...]
SDCBP2 protein networkhttps://string-db.org/network/9606.ENSP00000371233Syntenin-2; Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival.
CYS1 protein networkhttps://string-db.org/network/9606.ENSP00000371234Cystin-1; Cystin 1.
GART protein networkhttps://string-db.org/network/9606.ENSP00000371253Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central s [...]
YWHAQ protein networkhttps://string-db.org/network/9606.ENSP0000037126714-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognit [...]
PLIN5 protein networkhttps://string-db.org/network/9606.ENSP00000371272Perilipin-5; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to t [...]
CDC37L1 protein networkhttps://string-db.org/network/9606.ENSP00000371278Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.
SNPH protein networkhttps://string-db.org/network/9606.ENSP00000371291Syntaphilin; Inhibits SNARE complex formation by absorbing free syntaxin- 1.
CTNS protein networkhttps://string-db.org/network/9606.ENSP00000371294Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degr [...]
PLPP6 protein networkhttps://string-db.org/network/9606.ENSP00000371307Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunit [...]
CENPJ protein networkhttps://string-db.org/network/9606.ENSP00000371308Centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in [...]
TMEM74B protein networkhttps://string-db.org/network/9606.ENSP00000371318Transmembrane protein 74B.
RFC1 protein networkhttps://string-db.org/network/9606.ENSP00000371321Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds t [...]
KLRC2 protein networkhttps://string-db.org/network/9606.ENSP00000371327NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
KLRC3 protein networkhttps://string-db.org/network/9606.ENSP00000371328Killer cell lectin like receptor C3.
TNNI2 protein networkhttps://string-db.org/network/9606.ENSP00000371336Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase act [...]
TNK2 protein networkhttps://string-db.org/network/9606.ENSP00000371341Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Trans [...]
METTL22 protein networkhttps://string-db.org/network/9606.ENSP00000371345Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN. Belongs to the methyltransferase superfamily. METTL22 family.
ANGPT4 protein networkhttps://string-db.org/network/9606.ENSP00000371347Angiopoietin-4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
TMEM52B protein networkhttps://string-db.org/network/9606.ENSP00000371348Transmembrane protein 52B.
NADK2 protein networkhttps://string-db.org/network/9606.ENSP00000371362NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinas [...]
TMEM156 protein networkhttps://string-db.org/network/9606.ENSP00000371364Transmembrane protein 156.
OR1A2 protein networkhttps://string-db.org/network/9606.ENSP00000371377Olfactory receptor 1A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SRXN1 protein networkhttps://string-db.org/network/9606.ENSP00000371388Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act o [...]
PGM2 protein networkhttps://string-db.org/network/9606.ENSP00000371393Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. May also catalyze the i [...]
SYT8 protein networkhttps://string-db.org/network/9606.ENSP00000371394Synaptotagmin-8; Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)- regulation of exocytosis acrosomal reaction in sperm. [...]
FAM43A protein networkhttps://string-db.org/network/9606.ENSP00000371397Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family.
GLIS3 protein networkhttps://string-db.org/network/9606.ENSP00000371398Zinc finger protein GLIS3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).
C4orf19 protein networkhttps://string-db.org/network/9606.ENSP00000371408Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19.
PARP4 protein networkhttps://string-db.org/network/9606.ENSP00000371419Protein mono-ADP-ribosyltransferase PARP4; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins.
GPNMB protein networkhttps://string-db.org/network/9606.ENSP00000371420Transmembrane glycoprotein NMB; Could be a melanogenic enzyme; Belongs to the PMEL/NMB family.
IFNGR2 protein networkhttps://string-db.org/network/9606.ENSP00000371425Interferon gamma receptor 2; Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required f [...]
RFX3 protein networkhttps://string-db.org/network/9606.ENSP00000371434Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocili [...]
DNAJC21 protein networkhttps://string-db.org/network/9606.ENSP00000371451DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S [...]
RAD1 protein networkhttps://string-db.org/network/9606.ENSP00000371469Cell cycle checkpoint protein RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage b [...]
RSAD2 protein networkhttps://string-db.org/network/9606.ENSP00000371471Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced [...]
NIN protein networkhttps://string-db.org/network/9606.ENSP00000371472Ninein; Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtub [...]
TP53BP1 protein networkhttps://string-db.org/network/9606.ENSP00000371475TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key ro [...]
SLC34A2 protein networkhttps://string-db.org/network/9606.ENSP00000371483Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intesti [...]
C1QTNF3 protein networkhttps://string-db.org/network/9606.ENSP00000371497Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3.
C1QTNF9 protein networkhttps://string-db.org/network/9606.ENSP00000371503Complement C1q and tumor necrosis factor-related protein 9A; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
CLEC6A protein networkhttps://string-db.org/network/9606.ENSP00000371505C-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the [...]
SGCZ protein networkhttps://string-db.org/network/9606.ENSP00000371512Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May p [...]
KCNV2 protein networkhttps://string-db.org/network/9606.ENSP00000371514Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belo [...]
AMACR protein networkhttps://string-db.org/network/9606.ENSP00000371517Alpha-methylacyl-CoA racemase; Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters. Acts only on coenzyme A thioesters, not on free fa [...]
C22orf42 protein networkhttps://string-db.org/network/9606.ENSP00000371529Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42.
VLDLR protein networkhttps://string-db.org/network/9606.ENSP00000371532Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated p [...]
SEPSECS protein networkhttps://string-db.org/network/9606.ENSP00000371535O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family.
LGI2 protein networkhttps://string-db.org/network/9606.ENSP00000371548Leucine-rich repeat LGI family member 2; Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells.
NANOGNB protein networkhttps://string-db.org/network/9606.ENSP00000371553NANOG neighbor homeobox.
SOD3 protein networkhttps://string-db.org/network/9606.ENSP00000371554Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
C1QTNF9B protein networkhttps://string-db.org/network/9606.ENSP00000371572Complement C1q and tumor necrosis factor-related protein 9B; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.
MTMR12 protein networkhttps://string-db.org/network/9606.ENSP00000371577Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing [...]
KCNIP4 protein networkhttps://string-db.org/network/9606.ENSP00000371587Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and [...]
GNG7 protein networkhttps://string-db.org/network/9606.ENSP00000371594Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
KRTAP5-6 protein networkhttps://string-db.org/network/9606.ENSP00000371595Keratin-associated protein 5-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
KRTAP5-1 protein networkhttps://string-db.org/network/9606.ENSP00000371606Keratin-associated protein 5-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
MIPEP protein networkhttps://string-db.org/network/9606.ENSP00000371607Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size.
BRSK2 protein networkhttps://string-db.org/network/9606.ENSP00000371614Serine/threonine-protein kinase BRSK2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates [...]
SMARCA2 protein networkhttps://string-db.org/network/9606.ENSP00000371638Probable global transcription activator SNF2L2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of [...]
DEFB135 protein networkhttps://string-db.org/network/9606.ENSP00000371643Beta-defensin 135; Has antibacterial activity; Belongs to the beta-defensin family.
DEFB136 protein networkhttps://string-db.org/network/9606.ENSP00000371644Beta-defensin 136; Has antibacterial activity; Belongs to the beta-defensin family.
LCORL protein networkhttps://string-db.org/network/9606.ENSP00000371661Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatog [...]
DCAF16 protein networkhttps://string-db.org/network/9606.ENSP00000371682DDB1- and CUL4-associated factor 16; Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degra [...]
DMRT2 protein networkhttps://string-db.org/network/9606.ENSP00000371686Doublesex- and mab-3-related transcription factor 2; Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific m [...]
CDH12 protein networkhttps://string-db.org/network/9606.ENSP00000371689Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
TNFRSF19 protein networkhttps://string-db.org/network/9606.ENSP00000371693Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
CDH18 protein networkhttps://string-db.org/network/9606.ENSP00000371710Cadherin-18; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
DMRT1 protein networkhttps://string-db.org/network/9606.ENSP00000371711Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell [...]
ZG16B protein networkhttps://string-db.org/network/9606.ENSP00000371715Zymogen granule protein 16B; Belongs to the jacalin lectin family.
BPY2C protein networkhttps://string-db.org/network/9606.ENSP00000371724Basic charge Y-linked 2C.
NRSN2 protein networkhttps://string-db.org/network/9606.ENSP00000371728Neurensin-2; May play a role in maintenance and/or transport of vesicles; Belongs to the VMP family.
SACS protein networkhttps://string-db.org/network/9606.ENSP00000371729Sacsin; Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins.
FGFBP1 protein networkhttps://string-db.org/network/9606.ENSP00000371770Fibroblast growth factor-binding protein 1; Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic acti [...]
OLIG1 protein networkhttps://string-db.org/network/9606.ENSP00000371785Oligodendrocyte transcription factor 1; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neur [...]
ONECUT3 protein networkhttps://string-db.org/network/9606.ENSP00000371786One cut domain family member 3; Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity); Belo [...]
FGF9 protein networkhttps://string-db.org/network/9606.ENSP00000371790Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth a [...]
FSCN1 protein networkhttps://string-db.org/network/9606.ENSP00000371798Fascin; Actin-binding protein that contains 2 major actin binding sites. Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the form [...]
RNF215 protein networkhttps://string-db.org/network/9606.ENSP00000371800Ring finger protein 215.
DAZ3 protein networkhttps://string-db.org/network/9606.ENSP00000371802Deleted in azoospermia protein 2; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
FBXL18 protein networkhttps://string-db.org/network/9606.ENSP00000371805F-box/LRR-repeat protein 18; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
MICU2 protein networkhttps://string-db.org/network/9606.ENSP00000371811Calcium uptake protein 2, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a dis [...]
DEFB132 protein networkhttps://string-db.org/network/9606.ENSP00000371813Beta-defensin 132; Has antibacterial activity; Belongs to the beta-defensin family.
DEFB127 protein networkhttps://string-db.org/network/9606.ENSP00000371825Beta-defensin 127; Has antibacterial activity.
BPY2B protein networkhttps://string-db.org/network/9606.ENSP00000371829Basic charge Y-linked 2B.
DEFB126 protein networkhttps://string-db.org/network/9606.ENSP00000371835Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm [...]
CBWD5 protein networkhttps://string-db.org/network/9606.ENSP00000371842COBW domain containing 5.
DEAF1 protein networkhttps://string-db.org/network/9606.ENSP00000371846Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. D [...]
DEFB125 protein networkhttps://string-db.org/network/9606.ENSP00000371847Beta-defensin 125; Has antibacterial activity; Belongs to the beta-defensin family.
NOP2 protein networkhttps://string-db.org/network/9606.ENSP00000371858Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) [...]
BAZ1A protein networkhttps://string-db.org/network/9606.ENSP00000371859Bromodomain adjacent to zinc finger domain protein 1A; Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate eve [...]
DAZ2 protein networkhttps://string-db.org/network/9606.ENSP00000371870Deleted in azoospermia 2.
SLC35G5 protein networkhttps://string-db.org/network/9606.ENSP00000371872Solute carrier family 35 member G5.
NKX3-2 protein networkhttps://string-db.org/network/9606.ENSP00000371875Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric mor [...]
JMJD7-PLA2G4B protein networkhttps://string-db.org/network/9606.ENSP00000371886Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7; JMJD7-PLA2G4B readthrough.
ARHGAP5 protein networkhttps://string-db.org/network/9606.ENSP00000371897Rho GTPase-activating protein 5; GTPase-activating protein for Rho family members.
RP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000371923Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity).
GPR78 protein networkhttps://string-db.org/network/9606.ENSP00000371927G-protein coupled receptor 78; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in [...]
HTR3D protein networkhttps://string-db.org/network/9606.ENSP000003719295-hydroxytryptamine receptor 3D; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
TAS2R1 protein networkhttps://string-db.org/network/9606.ENSP00000371932Taste receptor type 2 member 1; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
SEMA5A protein networkhttps://string-db.org/network/9606.ENSP00000371936Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory e [...]
FOXD4 protein networkhttps://string-db.org/network/9606.ENSP00000371940Forkhead box D4.
CD9 protein networkhttps://string-db.org/network/9606.ENSP00000371958CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at [...]
KCNA1 protein networkhttps://string-db.org/network/9606.ENSP00000371985Potassium voltage-gated channel subfamily A member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the centra [...]
NYNRIN protein networkhttps://string-db.org/network/9606.ENSP00000371994Protein NYNRIN; NYN domain and retroviral integrase containing.
DNAJC19 protein networkhttps://string-db.org/network/9606.ENSP00000372005Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inne [...]
CHEK2 protein networkhttps://string-db.org/network/9606.ENSP00000372023Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presen [...]
LATS2 protein networkhttps://string-db.org/network/9606.ENSP00000372035Serine/threonine-protein kinase LATS2; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...]
PPP2R2C protein networkhttps://string-db.org/network/9606.ENSP00000372042Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...]
IFITM5 protein networkhttps://string-db.org/network/9606.ENSP00000372059Interferon-induced transmembrane protein 5; Required for normal bone mineralization. Belongs to the CD225/Dispanin family.
PRMT8 protein networkhttps://string-db.org/network/9606.ENSP00000372067Protein arginine N-methyltransferase 8; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MM [...]
RBMY1E protein networkhttps://string-db.org/network/9606.ENSP00000372105RNA-binding motif protein, Y chromosome, family 1 member E; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA spl [...]
FAHD1 protein networkhttps://string-db.org/network/9606.ENSP00000372112Acylpyruvase FAHD1, mitochondrial; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity.
RBMY1D protein networkhttps://string-db.org/network/9606.ENSP00000372127RNA-binding motif protein, Y chromosome, family 1 member D; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA spl [...]
DEFA1B protein networkhttps://string-db.org/network/9606.ENSP00000372136Neutrophil defensin 1; Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are [...]
DEFA1 protein networkhttps://string-db.org/network/9606.ENSP00000372139Defensin alpha 1.
RBMY1A1 protein networkhttps://string-db.org/network/9606.ENSP00000372154RNA-binding motif protein, Y chromosome, family 1 member A1; RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclus [...]
PSME1 protein networkhttps://string-db.org/network/9606.ENSP00000372155Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I bindin [...]
DOK6 protein networkhttps://string-db.org/network/9606.ENSP00000372160Docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- [...]
CACNA2D4 protein networkhttps://string-db.org/network/9606.ENSP00000372169Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...]
MSX1 protein networkhttps://string-db.org/network/9606.ENSP00000372170Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the devel [...]
SIRT3 protein networkhttps://string-db.org/network/9606.ENSP00000372191NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known t [...]
CLCN7 protein networkhttps://string-db.org/network/9606.ENSP00000372193H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysoso [...]
URB1 protein networkhttps://string-db.org/network/9606.ENSP00000372199Nucleolar pre-ribosomal-associated protein 1; URB1 ribosome biogenesis homolog.
TMEM128 protein networkhttps://string-db.org/network/9606.ENSP00000372201Transmembrane protein 128.
EEF1AKMT1 protein networkhttps://string-db.org/network/9606.ENSP00000372206EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase su [...]
BET1L protein networkhttps://string-db.org/network/9606.ENSP00000372210BET1-like protein; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity).
SERPINB12 protein networkhttps://string-db.org/network/9606.ENSP00000372218Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily.
SERPINB5 protein networkhttps://string-db.org/network/9606.ENSP00000372221Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characte [...]
KRTAP19-8 protein networkhttps://string-db.org/network/9606.ENSP00000372272Keratin-associated protein 19-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
FBXO25 protein networkhttps://string-db.org/network/9606.ENSP00000372274F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) pro [...]
KRTAP20-3 protein networkhttps://string-db.org/network/9606.ENSP00000372276Keratin-associated protein 20-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP20-4 protein networkhttps://string-db.org/network/9606.ENSP00000372278Putative keratin-associated protein 20-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTA [...]
KRTAP27-1 protein networkhttps://string-db.org/network/9606.ENSP00000372286Keratin-associated protein 27-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
GJB2 protein networkhttps://string-db.org/network/9606.ENSP00000372295Gap junction beta-2 protein; Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hex [...]
MSLN protein networkhttps://string-db.org/network/9606.ENSP00000372313Megakaryocyte-potentiating factor; Membrane-anchored forms may play a role in cellular adhesion; Belongs to the mesothelin family.
NSD2 protein networkhttps://string-db.org/network/9606.ENSP00000372351Histone-lysine N-methyltransferase NSD2; Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity forming trimethylated 'Lys-27' (H3K27me3). Isoform 2 may act as a [...]
ZMYM5 protein networkhttps://string-db.org/network/9606.ENSP00000372361Zinc finger MYM-type protein 5; Functions as a transcriptional regulator.
SLC7A4 protein networkhttps://string-db.org/network/9606.ENSP00000372390Cationic amino acid transporter 4; Involved in the transport of the cationic amino acids (arginine, lysine and ornithine); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cati [...]
TMEM129 protein networkhttps://string-db.org/network/9606.ENSP00000372394E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins [...]
RNASE13 protein networkhttps://string-db.org/network/9606.ENSP00000372410Probable inactive ribonuclease-like protein 13; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family.
METTL17 protein networkhttps://string-db.org/network/9606.ENSP00000372445Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family.
CTIF protein networkhttps://string-db.org/network/9606.ENSP00000372459CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after [...]
TSPY8 protein networkhttps://string-db.org/network/9606.ENSP00000372462Testis specific protein Y-linked 8; Belongs to the nucleosome assembly protein (NAP) family.
TSPY4 protein networkhttps://string-db.org/network/9606.ENSP00000372471Testis specific protein Y-linked 4; Belongs to the nucleosome assembly protein (NAP) family.
SNRNP25 protein networkhttps://string-db.org/network/9606.ENSP00000372482Small nuclear ribonucleoprotein U11/U12 subunit 25.
RBMY1B protein networkhttps://string-db.org/network/9606.ENSP00000372484RNA-binding motif protein, Y chromosome, family 1 member B; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA spl [...]
TBL1Y protein networkhttps://string-db.org/network/9606.ENSP00000372499F-box-like/WD repeat-containing protein TBL1Y; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an e [...]
AMELY protein networkhttps://string-db.org/network/9606.ENSP00000372505Amelogenin, Y isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in t [...]
TSPY2 protein networkhttps://string-db.org/network/9606.ENSP00000372512Testis specific protein Y-linked 2; Belongs to the nucleosome assembly protein (NAP) family.
SRY protein networkhttps://string-db.org/network/9606.ENSP00000372547Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing t [...]
PRR23A protein networkhttps://string-db.org/network/9606.ENSP00000372649Proline-rich protein 23A; Proline rich 23A; Belongs to the PRR23 family.
FOXL2NB protein networkhttps://string-db.org/network/9606.ENSP00000372651FOXL2 neighbor.
STAG1 protein networkhttps://string-db.org/network/9606.ENSP00000372689Cohesin subunit SA-1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring [...]
TMEM241 protein networkhttps://string-db.org/network/9606.ENSP00000372720Transmembrane protein 241.
LY6G5C protein networkhttps://string-db.org/network/9606.ENSP00000372724Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation.
CHRM5 protein networkhttps://string-db.org/network/9606.ENSP00000372750Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...]
NEK11 protein networkhttps://string-db.org/network/9606.ENSP00000372857Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on [...]
LY6G6E protein networkhttps://string-db.org/network/9606.ENSP00000372910Lymphocyte antigen 6 family member G6E.
RALBP1 protein networkhttps://string-db.org/network/9606.ENSP00000372924RalA-binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4- dinitrophenyl)-glutathione (DNP-SG) and doxo [...]
HMCES protein networkhttps://string-db.org/network/9606.ENSP00000372955Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme [...]
LRRC30 protein networkhttps://string-db.org/network/9606.ENSP00000372959Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30.
TXNRD3NB protein networkhttps://string-db.org/network/9606.ENSP00000373066Protein TXNRD3NB.
UROC1 protein networkhttps://string-db.org/network/9606.ENSP00000373073Urocanate hydratase 1.
HACD2 protein networkhttps://string-db.org/network/9606.ENSP00000373153Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, [...]
DRD3 protein networkhttps://string-db.org/network/9606.ENSP00000373169D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
GTPBP8 protein networkhttps://string-db.org/network/9606.ENSP00000373176GTP binding protein 8.
LNP1 protein networkhttps://string-db.org/network/9606.ENSP00000373191Leukemia NUP98 fusion partner 1.
OR5K3 protein networkhttps://string-db.org/network/9606.ENSP00000373194Olfactory receptor 5K3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
EOGT protein networkhttps://string-db.org/network/9606.ENSP00000373206EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins res [...]
CADPS protein networkhttps://string-db.org/network/9606.ENSP00000373215Calcium-dependent secretion activator 1; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogen [...]
CSPG5 protein networkhttps://string-db.org/network/9606.ENSP00000373244Chondroitin sulfate proteoglycan 5; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
TRIM71 protein networkhttps://string-db.org/network/9606.ENSP00000373272E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). B [...]
ZNF860 protein networkhttps://string-db.org/network/9606.ENSP00000373274Zinc finger protein 860; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RBMS3 protein networkhttps://string-db.org/network/9606.ENSP00000373277RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides.
ZCWPW2 protein networkhttps://string-db.org/network/9606.ENSP00000373278Zinc finger CW-type and PWWP domain containing 2.
COLQ protein networkhttps://string-db.org/network/9606.ENSP00000373298Acetylcholinesterase collagenic tail peptide; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina; Belongs to the COLQ family.
SH3BP5 protein networkhttps://string-db.org/network/9606.ENSP00000373301SH3 domain-binding protein 5; Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a neg [...]
CCDC174 protein networkhttps://string-db.org/network/9606.ENSP00000373304Coiled-coil domain-containing protein 174; Probably involved in neuronal development.
SEC13 protein networkhttps://string-db.org/network/9606.ENSP00000373312Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. R [...]
IL17RE protein networkhttps://string-db.org/network/9606.ENSP00000373325Interleukin-17 receptor E; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator [...]
CIDEC protein networkhttps://string-db.org/network/9606.ENSP00000373328Cell death activator CIDE-3; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes d [...]
RPUSD3 protein networkhttps://string-db.org/network/9606.ENSP00000373331Mitochondrial mRNA pseudouridine synthase RPUSD3; Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post- transcriptional modifica [...]
BRPF1 protein networkhttps://string-db.org/network/9606.ENSP00000373340Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 [...]
CPNE9 protein networkhttps://string-db.org/network/9606.ENSP00000373343Copine-9; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocyt [...]
SRGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000373347SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
SETMAR protein networkhttps://string-db.org/network/9606.ENSP00000373354Histone-lysine N-methyltransferase SETMAR; Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double- strand break repair, stalle [...]
FAM131A protein networkhttps://string-db.org/network/9606.ENSP00000373360Protein FAM131A; Family with sequence similarity 131 member A.
GOLM1 protein networkhttps://string-db.org/network/9606.ENSP00000373364Golgi membrane protein 1; Unknown. Cellular response protein to viral infection.
FLG2 protein networkhttps://string-db.org/network/9606.ENSP00000373370Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-termina [...]
PIP5KL1 protein networkhttps://string-db.org/network/9606.ENSP00000373399Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4 [...]
MRPL2 protein networkhttps://string-db.org/network/9606.ENSP00000373404Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family.
UFSP1 protein networkhttps://string-db.org/network/9606.ENSP00000373413Inactive Ufm1-specific protease 1; UFM1 specific peptidase 1; Belongs to the peptidase C78 family.
RUFY2 protein networkhttps://string-db.org/network/9606.ENSP00000373420RUN and FYVE domain containing 2.
LAMB4 protein networkhttps://string-db.org/network/9606.ENSP00000373433Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
SPAG1 protein networkhttps://string-db.org/network/9606.ENSP00000373450Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity.
ADAMTS7 protein networkhttps://string-db.org/network/9606.ENSP00000373472A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP.
METTL14 protein networkhttps://string-db.org/network/9606.ENSP00000373474N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and [...]
GPX3 protein networkhttps://string-db.org/network/9606.ENSP00000373477Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
KRT18 protein networkhttps://string-db.org/network/9606.ENSP00000373489Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved [...]
NOX5 protein networkhttps://string-db.org/network/9606.ENSP00000373518NADPH oxidase 5; Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and sper [...]
STAB2 protein networkhttps://string-db.org/network/9606.ENSP00000373539190 kDa form stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also [...]
FAM83H protein networkhttps://string-db.org/network/9606.ENSP00000373565Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin f [...]
CCDC158 protein networkhttps://string-db.org/network/9606.ENSP00000373566Coiled-coil domain containing 158.
TYRP1 protein networkhttps://string-db.org/network/9606.ENSP000003735705,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic [...]
FOXI2 protein networkhttps://string-db.org/network/9606.ENSP00000373572Forkhead box protein I2; Possible transcriptional activator.
ACVRL1 protein networkhttps://string-db.org/network/9606.ENSP00000373574Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a [...]
C6orf163 protein networkhttps://string-db.org/network/9606.ENSP00000373575Uncharacterized protein C6orf163; Chromosome 6 open reading frame 163.
STPG3 protein networkhttps://string-db.org/network/9606.ENSP00000373583Protein STPG3; Sperm-tail PG-rich repeat containing 3.
MAB21L4 protein networkhttps://string-db.org/network/9606.ENSP00000373586Protein mab-21-like 4; Mab-21 like 4.
TMEM266 protein networkhttps://string-db.org/network/9606.ENSP00000373594Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage- sensor se [...]
LRRK1 protein networkhttps://string-db.org/network/9606.ENSP00000373600Leucine rich repeat kinase 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.
SEPTIN14 protein networkhttps://string-db.org/network/9606.ENSP00000373627Septin-14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
HYKK protein networkhttps://string-db.org/network/9606.ENSP00000373640Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine.
FAM83G protein networkhttps://string-db.org/network/9606.ENSP00000373647Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway.
KCNQ3 protein networkhttps://string-db.org/network/9606.ENSP00000373648Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-cur [...]
NCBP3 protein networkhttps://string-db.org/network/9606.ENSP00000373657Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking [...]
BORCS6 protein networkhttps://string-db.org/network/9606.ENSP00000373669BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...]
NT5M protein networkhttps://string-db.org/network/9606.ENSP000003736745'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication f [...]
STK38L protein networkhttps://string-db.org/network/9606.ENSP00000373684Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells; Belongs to the protein kinase superfamily. AGC Ser/Thr pr [...]
DUOX2 protein networkhttps://string-db.org/network/9606.ENSP00000373691Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-me [...]
TRIP12 protein networkhttps://string-db.org/network/9606.ENSP00000373696E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) [...]
ALK protein networkhttps://string-db.org/network/9606.ENSP00000373700ALK tyrosine kinase receptor; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an import [...]
PP2D1 protein networkhttps://string-db.org/network/9606.ENSP00000373702Protein phosphatase 2C like domain containing 1.
DIAPH1 protein networkhttps://string-db.org/network/9606.ENSP00000373706Protein diaphanous homolog 1; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed e [...]
DCP2 protein networkhttps://string-db.org/network/9606.ENSP00000373715m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphor [...]
SHISAL2B protein networkhttps://string-db.org/network/9606.ENSP00000373726Protein shisa-like-2B; Shisa like 2B.
RNF180 protein networkhttps://string-db.org/network/9606.ENSP00000373752E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
RNF20 protein networkhttps://string-db.org/network/9606.ENSP00000373772E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a spec [...]
LOXL2 protein networkhttps://string-db.org/network/9606.ENSP00000373783Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). Acts as a transcript [...]
FAM169A protein networkhttps://string-db.org/network/9606.ENSP00000373808Soluble lamin-associated protein of 75 kDa; Family with sequence similarity 169 member A; Belongs to the FAM169 family.
CCDC150 protein networkhttps://string-db.org/network/9606.ENSP00000373827Coiled-coil domain containing 150.
CCDC154 protein networkhttps://string-db.org/network/9606.ENSP00000373828Coiled-coil domain containing 154.
ITGAD protein networkhttps://string-db.org/network/9606.ENSP00000373854Integrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood [...]
ASPDH protein networkhttps://string-db.org/network/9606.ENSP00000373860Putative L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
DNM2 protein networkhttps://string-db.org/network/9606.ENSP00000373905Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon g [...]
GARS1 protein networkhttps://string-db.org/network/9606.ENSP00000373918Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenos [...]
PRTG protein networkhttps://string-db.org/network/9606.ENSP00000373937Protogenin; May play a role in anteroposterior axis elongation. Belongs to the immunoglobulin superfamily. DCC family.
CFAP69 protein networkhttps://string-db.org/network/9606.ENSP00000373948Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus c [...]
FANCA protein networkhttps://string-db.org/network/9606.ENSP00000373952Fanconi anemia group A protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in th [...]
SMTNL2 protein networkhttps://string-db.org/network/9606.ENSP00000373964Smoothelin-like protein 2; Smoothelin like 2.
TRAPPC9 protein networkhttps://string-db.org/network/9606.ENSP00000373979Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May p [...]
PRB2 protein networkhttps://string-db.org/network/9606.ENSP00000374013Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2.
TM6SF2 protein networkhttps://string-db.org/network/9606.ENSP00000374014Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase. Belongs to the TM6S [...]
RPH3A protein networkhttps://string-db.org/network/9606.ENSP00000374036Rabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane i [...]
VPS9D1 protein networkhttps://string-db.org/network/9606.ENSP00000374037VPS9 domain containing 1.
DNAH6 protein networkhttps://string-db.org/network/9606.ENSP00000374045Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
VWA3A protein networkhttps://string-db.org/network/9606.ENSP00000374049Von Willebrand factor A domain containing 3A.
PTPRN2 protein networkhttps://string-db.org/network/9606.ENSP00000374069Receptor-type tyrosine-protein phosphatase N2; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreati [...]
ADAMTS20 protein networkhttps://string-db.org/network/9606.ENSP00000374071A disintegrin and metalloproteinase with thrombospondin motifs 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independ [...]
PTMS protein networkhttps://string-db.org/network/9606.ENSP00000374113Parathymosin.
SIGLEC15 protein networkhttps://string-db.org/network/9606.ENSP00000374125Sialic acid-binding Ig-like lectin 15; Binds sialylated glycoproteins.
LRP1B protein networkhttps://string-db.org/network/9606.ENSP00000374135Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.
SMYD5 protein networkhttps://string-db.org/network/9606.ENSP00000374152SET and MYND domain-containing protein 5; SMYD family member 5; Belongs to the class V-like SAM-binding methyltransferase superfamily.
CAMSAP1 protein networkhttps://string-db.org/network/9606.ENSP00000374183Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...]
TBR1 protein networkhttps://string-db.org/network/9606.ENSP00000374205T-box brain protein 1; Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcri [...]
EP400 protein networkhttps://string-db.org/network/9606.ENSP00000374212E1A-binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone [...]
ESYT3 protein networkhttps://string-db.org/network/9606.ENSP00000374218Extended synaptotagmin-3; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membran [...]
TMEM72 protein networkhttps://string-db.org/network/9606.ENSP00000374234Transmembrane protein 72.
NXPE2 protein networkhttps://string-db.org/network/9606.ENSP00000374237NXPE family member 2; Neurexophilin and PC-esterase domain family member 2; Belongs to the NXPE family.
SHOX2 protein networkhttps://string-db.org/network/9606.ENSP00000374240Short stature homeobox protein 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure fo [...]
GPX2 protein networkhttps://string-db.org/network/9606.ENSP00000374265Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydr [...]
GXYLT2 protein networkhttps://string-db.org/network/9606.ENSP00000374268Glucoside xylosyltransferase 2; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of x [...]
CRYBG3 protein networkhttps://string-db.org/network/9606.ENSP00000374273Very large A-kinase anchor protein; [Isoform vlAKAP]: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA).
SSC5D protein networkhttps://string-db.org/network/9606.ENSP00000374274Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D; Binds to extracellular matrix proteins. Binds to pathogen- associated molecular patterns (PAMPs) present on the cell wall [...]
RTF1 protein networkhttps://string-db.org/network/9606.ENSP00000374280RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of dev [...]
LAMA1 protein networkhttps://string-db.org/network/9606.ENSP00000374309Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
EPHA6 protein networkhttps://string-db.org/network/9606.ENSP00000374323Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
FAXC protein networkhttps://string-db.org/network/9606.ENSP00000374328Failed axon connections homolog; May play a role in axonal development.
TSN protein networkhttps://string-db.org/network/9606.ENSP00000374332Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene [...]
HAGHL protein networkhttps://string-db.org/network/9606.ENSP00000374353Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds.
EXOSC8 protein networkhttps://string-db.org/network/9606.ENSP00000374354Exosome complex component RRP43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...]
ZXDC protein networkhttps://string-db.org/network/9606.ENSP00000374359Zinc finger protein ZXDC; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Belongs to the ZXD family.
RFLNA protein networkhttps://string-db.org/network/9606.ENSP00000374377Refilin-A; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing c [...]
TRMT44 protein networkhttps://string-db.org/network/9606.ENSP00000374387Probable tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Belongs to the TRM44 family.
GPR149 protein networkhttps://string-db.org/network/9606.ENSP00000374390Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
TRMT61A protein networkhttps://string-db.org/network/9606.ENSP00000374399tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 5 [...]
PKP4 protein networkhttps://string-db.org/network/9606.ENSP00000374409Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
ARHGAP8 protein networkhttps://string-db.org/network/9606.ENSP00000374424Rho GTPase-activating protein 8; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
LYST protein networkhttps://string-db.org/network/9606.ENSP00000374443Lysosomal-trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules.
LRCH1 protein networkhttps://string-db.org/network/9606.ENSP00000374447Leucine-rich repeat and calponin homology domain-containing protein 1; Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC [...]
SQSTM1 protein networkhttps://string-db.org/network/9606.ENSP00000374455Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the c [...]
MRGPRE protein networkhttps://string-db.org/network/9606.ENSP00000374482Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coup [...]
TMEM87A protein networkhttps://string-db.org/network/9606.ENSP00000374484Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
DNAH17 protein networkhttps://string-db.org/network/9606.ENSP00000374490Dynein heavy chain 17, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
CCDC88C protein networkhttps://string-db.org/network/9606.ENSP00000374507Protein Daple; Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from th [...]
CCNK protein networkhttps://string-db.org/network/9606.ENSP00000374529Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of t [...]
RNF216 protein networkhttps://string-db.org/network/9606.ENSP00000374552E3 ubiquitin-protein ligase RNF216; Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting [...]
COX16 protein networkhttps://string-db.org/network/9606.ENSP00000374562Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes [...]
FAM168B protein networkhttps://string-db.org/network/9606.ENSP00000374565Myelin-associated neurite-outgrowth inhibitor; Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC [...]
KIF19 protein networkhttps://string-db.org/network/9606.ENSP00000374566Kinesin-like protein KIF19; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
TMEM95 protein networkhttps://string-db.org/network/9606.ENSP00000374632Transmembrane protein 95.
IL17REL protein networkhttps://string-db.org/network/9606.ENSP00000374633Putative interleukin-17 receptor E-like; Interleukin 17 receptor E like.
TMEM203 protein networkhttps://string-db.org/network/9606.ENSP00000375053Transmembrane protein 203; Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis.
NLRP5 protein networkhttps://string-db.org/network/9606.ENSP00000375063NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; [...]
HCAR2 protein networkhttps://string-db.org/network/9606.ENSP00000375066Hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and de [...]
COL23A1 protein networkhttps://string-db.org/network/9606.ENSP00000375069Collagen type XXIII alpha 1 chain.
EID2 protein networkhttps://string-db.org/network/9606.ENSP00000375073EP300-interacting inhibitor of differentiation 2; Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferas [...]
KRTAP4-4 protein networkhttps://string-db.org/network/9606.ENSP00000375076Keratin associated protein 4-4.
PPP2R3B protein networkhttps://string-db.org/network/9606.ENSP00000375080Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the locali [...]
TSSK1B protein networkhttps://string-db.org/network/9606.ENSP00000375081Testis-specific serine/threonine-protein kinase 1; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late st [...]
CCL25 protein networkhttps://string-db.org/network/9606.ENSP00000375086C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on [...]
TAS2R19 protein networkhttps://string-db.org/network/9606.ENSP00000375091Taste receptor type 2 member 19; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
TAS2R31 protein networkhttps://string-db.org/network/9606.ENSP00000375093Taste receptor type 2 member 31; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
TAS2R13 protein networkhttps://string-db.org/network/9606.ENSP00000375095Taste receptor type 2 member 13; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
KRTAP19-6 protein networkhttps://string-db.org/network/9606.ENSP00000375107Keratin-associated protein 19-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP19-1 protein networkhttps://string-db.org/network/9606.ENSP00000375108Keratin-associated protein 19-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP13-3 protein networkhttps://string-db.org/network/9606.ENSP00000375109Keratin-associated protein 13-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP16-1 protein networkhttps://string-db.org/network/9606.ENSP00000375147Keratin associated protein 16-1; Belongs to the KRTAP type 16 family.
KRTAP29-1 protein networkhttps://string-db.org/network/9606.ENSP00000375148Keratin associated like protein 29-1; Belongs to the KRTAP type 10 family.
KRTAP9-7 protein networkhttps://string-db.org/network/9606.ENSP00000375149Keratin-associated protein 9-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP9-6 protein networkhttps://string-db.org/network/9606.ENSP00000375150Keratin-associated protein 9-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP4-3 protein networkhttps://string-db.org/network/9606.ENSP00000375151Keratin-associated protein 4-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
CTAGE1 protein networkhttps://string-db.org/network/9606.ENSP00000375220cTAGE family member 2; Cutaneous T cell lymphoma-associated antigen 1.
KRTAP4-11 protein networkhttps://string-db.org/network/9606.ENSP00000375232Keratin associated protein 4-11.
KRTAP4-9 protein networkhttps://string-db.org/network/9606.ENSP00000375234Keratin associated protein 4-9.
KRTAP4-7 protein networkhttps://string-db.org/network/9606.ENSP00000375236Keratin associated protein 4-7.
KRTAP2-3 protein networkhttps://string-db.org/network/9606.ENSP00000375237Keratin-associated protein 2-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP2-1 protein networkhttps://string-db.org/network/9606.ENSP00000375238Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
BHLHA9 protein networkhttps://string-db.org/network/9606.ENSP00000375248Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated [...]
RTL8A protein networkhttps://string-db.org/network/9606.ENSP00000375267Retrotransposon Gag like 8A; Belongs to the FAM127 family.
RTL8B protein networkhttps://string-db.org/network/9606.ENSP00000375268Retrotransposon Gag like 8B; Belongs to the FAM127 family.
KRTAP3-3 protein networkhttps://string-db.org/network/9606.ENSP00000375428Keratin-associated protein 3-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP3-2 protein networkhttps://string-db.org/network/9606.ENSP00000375429Keratin-associated protein 3-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP3-1 protein networkhttps://string-db.org/network/9606.ENSP00000375430Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP12-1 protein networkhttps://string-db.org/network/9606.ENSP00000375475Keratin associated protein 12-1.
KRTAP12-4 protein networkhttps://string-db.org/network/9606.ENSP00000375476Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP10-3 protein networkhttps://string-db.org/network/9606.ENSP00000375478Keratin-associated protein 10-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP10-2 protein networkhttps://string-db.org/network/9606.ENSP00000375479Keratin-associated protein 10-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP6-3 protein networkhttps://string-db.org/network/9606.ENSP00000375482Keratin-associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
ZNF552 protein networkhttps://string-db.org/network/9606.ENSP00000375582Zinc finger protein 552; May be involved in transcriptional regulation.
ZSCAN5A protein networkhttps://string-db.org/network/9606.ENSP00000375593Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation.
KIR3DL1 protein networkhttps://string-db.org/network/9606.ENSP00000375608Killer cell immunoglobulin-like receptor 3DL1; Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
LILRB4 protein networkhttps://string-db.org/network/9606.ENSP00000375616Leukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulati [...]
LILRA2 protein networkhttps://string-db.org/network/9606.ENSP00000375618Leukocyte immunoglobulin-like receptor subfamily A member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobuli [...]
LAIR1 protein networkhttps://string-db.org/network/9606.ENSP00000375622Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-c [...]
LILRB2 protein networkhttps://string-db.org/network/9606.ENSP00000375629Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-r [...]
RPS9 protein networkhttps://string-db.org/network/9606.ENSP00000375632Ribosomal protein S9.
TFPT protein networkhttps://string-db.org/network/9606.ENSP00000375639TCF3 fusion partner; Appears to promote apoptosis in a p53/TP53-independent manner.
CACNG7 protein networkhttps://string-db.org/network/9606.ENSP00000375647Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties [...]
MYADM protein networkhttps://string-db.org/network/9606.ENSP00000375649Myeloid associated differentiation marker; Belongs to the MAL family.
NLRP12 protein networkhttps://string-db.org/network/9606.ENSP00000375653NACHT, LRR and PYD domains-containing protein 12; Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical a [...]
KLK14 protein networkhttps://string-db.org/network/9606.ENSP00000375678Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and [...]
KLK8 protein networkhttps://string-db.org/network/9606.ENSP00000375682Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increas [...]
C19orf48 protein networkhttps://string-db.org/network/9606.ENSP00000375688Uncharacterized protein C19orf48; Chromosome 19 open reading frame 48.
AKT1S1 protein networkhttps://string-db.org/network/9606.ENSP00000375711Proline-rich AKT1 substrate 1; Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino [...]
PTOV1 protein networkhttps://string-db.org/network/9606.ENSP00000375717Prostate tumor-overexpressed gene 1 protein; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
RPL13A protein networkhttps://string-db.org/network/9606.ENSP0000037573060S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhi [...]
PGBD5 protein networkhttps://string-db.org/network/9606.ENSP00000375733PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene.
KCNJ14 protein networkhttps://string-db.org/network/9606.ENSP00000375756ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Th [...]
ZNF541 protein networkhttps://string-db.org/network/9606.ENSP00000375770Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.
STRN4 protein networkhttps://string-db.org/network/9606.ENSP00000375777Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family.
LAMB3 protein networkhttps://string-db.org/network/9606.ENSP00000375778Laminin subunit beta-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
DACT3 protein networkhttps://string-db.org/network/9606.ENSP00000375783Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathway [...]
IL24 protein networkhttps://string-db.org/network/9606.ENSP00000375795Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family.
ERCC2 protein networkhttps://string-db.org/network/9606.ENSP00000375809General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, whic [...]
KLC3 protein networkhttps://string-db.org/network/9606.ENSP00000375810Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; Belongs to the kinesin light chain family.
ZNF233 protein networkhttps://string-db.org/network/9606.ENSP00000375820Zinc finger protein 233; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PPP1R12B protein networkhttps://string-db.org/network/9606.ENSP00000375821Protein phosphatase 1 regulatory subunit 12B; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.
ZNF222 protein networkhttps://string-db.org/network/9606.ENSP00000375822Zinc finger protein 222; May be involved in transcriptional regulation.
LAD1 protein networkhttps://string-db.org/network/9606.ENSP00000375829Ladinin-1; Anchoring filament protein which is a component of the basement membrane zone.
HDLBP protein networkhttps://string-db.org/network/9606.ENSP00000375836Vigilin; Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
CAPN10 protein networkhttps://string-db.org/network/9606.ENSP00000375844Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insuli [...]
OTOS protein networkhttps://string-db.org/network/9606.ENSP00000375849Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear.
PDC protein networkhttps://string-db.org/network/9606.ENSP00000375855Phosducin; May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeob [...]
LRRFIP1 protein networkhttps://string-db.org/network/9606.ENSP00000375857Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF [...]
TMEM91 protein networkhttps://string-db.org/network/9606.ENSP00000375859Transmembrane protein 91; Belongs to the CD225/Dispanin family.
HNRNPUL1 protein networkhttps://string-db.org/network/9606.ENSP00000375863Heterogeneous nuclear ribonucleoprotein U-like protein 1; Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated [...]
ATG16L1 protein networkhttps://string-db.org/network/9606.ENSP00000375873Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C [...]
ALPP protein networkhttps://string-db.org/network/9606.ENSP00000375881Alkaline phosphatase, placental.
SERTAD3 protein networkhttps://string-db.org/network/9606.ENSP00000375882SERTA domain-containing protein 3; Strong transcriptional coactivator.
AKT2 protein networkhttps://string-db.org/network/9606.ENSP00000375892RAC-beta serine/threonine-protein kinase; AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includin [...]
SP140 protein networkhttps://string-db.org/network/9606.ENSP00000375899Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia [...]
LGALS16 protein networkhttps://string-db.org/network/9606.ENSP00000375904Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis.
SPHKAP protein networkhttps://string-db.org/network/9606.ENSP00000375909A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular [...]
RHBDD1 protein networkhttps://string-db.org/network/9606.ENSP00000375914Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and ju [...]
PAX3 protein networkhttps://string-db.org/network/9606.ENSP00000375921Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, act [...]
TTLL4 protein networkhttps://string-db.org/network/9606.ENSP00000375951Tubulin polyglutamylase TTLL4; Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the [...]
XRCC5 protein networkhttps://string-db.org/network/9606.ENSP00000375978X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork- [...]
MAP3K4 protein networkhttps://string-db.org/network/9606.ENSP00000375986Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically [...]
PNLDC1 protein networkhttps://string-db.org/network/9606.ENSP00000376007Poly(A)-specific ribonuclease PNLDC1; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) t [...]
ZNF566 protein networkhttps://string-db.org/network/9606.ENSP00000376010Zinc finger protein 566; May be involved in transcriptional regulation.
ZNF565 protein networkhttps://string-db.org/network/9606.ENSP00000376013Zinc finger protein 565; May be involved in transcriptional regulation.
SNX9 protein networkhttps://string-db.org/network/9606.ENSP00000376024Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. [...]
ZBTB32 protein networkhttps://string-db.org/network/9606.ENSP00000376035Zinc finger and BTB domain-containing protein 32; DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional r [...]
MAG protein networkhttps://string-db.org/network/9606.ENSP00000376048Myelin-associated glycoprotein; Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoprot [...]
EEF1B2 protein networkhttps://string-db.org/network/9606.ENSP00000376055Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
FAM117B protein networkhttps://string-db.org/network/9606.ENSP00000376071Protein FAM117B; Family with sequence similarity 117 member B.
SUMO1 protein networkhttps://string-db.org/network/9606.ENSP00000376077Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its s [...]
URI1 protein networkhttps://string-db.org/network/9606.ENSP00000376097Unconventional prefoldin RPB5 interactor 1; Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) t [...]
C19orf12 protein networkhttps://string-db.org/network/9606.ENSP00000376103Protein C19orf12; Chromosome 19 open reading frame 12.
ZNF493 protein networkhttps://string-db.org/network/9606.ENSP00000376110Zinc finger protein 493.
SH2D2A protein networkhttps://string-db.org/network/9606.ENSP00000376123SH2 domain-containing protein 2A; Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK- dependent signal transduction pathwa [...]
MYO1B protein networkhttps://string-db.org/network/9606.ENSP00000376132Unconventional myosin-Ib; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport; Belongs to [...]
ZNF605 protein networkhttps://string-db.org/network/9606.ENSP00000376135Zinc finger protein 605; May be involved in transcriptional regulation.
WDR45B protein networkhttps://string-db.org/network/9606.ENSP00000376139WD repeat domain phosphoinositide-interacting protein 3; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged [...]
MFSD6 protein networkhttps://string-db.org/network/9606.ENSP00000376141Major facilitator superfamily domain containing 6; Belongs to the major facilitator superfamily. MFSD6 family.
INPP1 protein networkhttps://string-db.org/network/9606.ENSP00000376142Inositol polyphosphate-1-phosphatase.
CCDC57 protein networkhttps://string-db.org/network/9606.ENSP00000376154Coiled-coil domain containing 57.
GPS1 protein networkhttps://string-db.org/network/9606.ENSP00000376167COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential [...]
CALCRL protein networkhttps://string-db.org/network/9606.ENSP00000376177Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Recep [...]
STX2 protein networkhttps://string-db.org/network/9606.ENSP00000376178Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm.
BDH1 protein networkhttps://string-db.org/network/9606.ENSP00000376184D-beta-hydroxybutyrate dehydrogenase, mitochondrial; 3-hydroxybutyrate dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
CRLF1 protein networkhttps://string-db.org/network/9606.ENSP00000376188Cytokine receptor-like factor 1; In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory rol [...]
TFRC protein networkhttps://string-db.org/network/9606.ENSP00000376197Transferrin receptor protein 1, serum form; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidific [...]
ASH1L protein networkhttps://string-db.org/network/9606.ENSP00000376204Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vi [...]
IQCN protein networkhttps://string-db.org/network/9606.ENSP00000376213IQ motif containing N.
TMEM200A protein networkhttps://string-db.org/network/9606.ENSP00000376224Transmembrane protein 200A; Belongs to the TMEM200 family.
TMEM44 protein networkhttps://string-db.org/network/9606.ENSP00000376227Transmembrane protein 44.
MB21D2 protein networkhttps://string-db.org/network/9606.ENSP00000376246Protein MB21D2; Mab-21 domain containing 2.
CCDC50 protein networkhttps://string-db.org/network/9606.ENSP00000376249Coiled-coil domain containing 50.
RNF34 protein networkhttps://string-db.org/network/9606.ENSP00000376258E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiqu [...]
SEC14L1 protein networkhttps://string-db.org/network/9606.ENSP00000376268SEC14-like protein 1; May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic se [...]
NCOA7 protein networkhttps://string-db.org/network/9606.ENSP00000376269Nuclear receptor coactivator 7; Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RA [...]
RFC4 protein networkhttps://string-db.org/network/9606.ENSP00000376272Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...]
SRSF2 protein networkhttps://string-db.org/network/9606.ENSP00000376276Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal compone [...]
LENEP protein networkhttps://string-db.org/network/9606.ENSP00000376278Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation.
CRYGS protein networkhttps://string-db.org/network/9606.ENSP00000376287Gamma-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
OSBPL6 protein networkhttps://string-db.org/network/9606.ENSP00000376293Oxysterol-binding protein-related protein 6; Regulates cellular transport and efflux of cholesterol. Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane (By s [...]
DYNLL1 protein networkhttps://string-db.org/network/9606.ENSP00000376297Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to [...]
CPT1C protein networkhttps://string-db.org/network/9606.ENSP00000376303Carnitine O-palmitoyltransferase 1, brain isoform; May play a role in lipid metabolic process. Belongs to the carnitine/choline acetyltransferase family.
TMEM121 protein networkhttps://string-db.org/network/9606.ENSP00000376304Transmembrane protein 121; May play a role in MAPK signaling. Belongs to the TMEM121 family.
CIT protein networkhttps://string-db.org/network/9606.ENSP00000376306Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO [...]
TEDC1 protein networkhttps://string-db.org/network/9606.ENSP00000376307Tubulin epsilon and delta complex protein 1; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability (By similarity). May play a role in counteracting perturb [...]
HNRNPA3 protein networkhttps://string-db.org/network/9606.ENSP00000376309Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
TAOK3 protein networkhttps://string-db.org/network/9606.ENSP00000376317Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator o [...]
HOXD13 protein networkhttps://string-db.org/network/9606.ENSP00000376322Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with sp [...]
WIPF1 protein networkhttps://string-db.org/network/9606.ENSP00000376330WAS/WASL-interacting protein family member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participa [...]
LLGL2 protein networkhttps://string-db.org/network/9606.ENSP00000376333LLGL scribble cell polarity complex component 2; Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for [...]
GPR155 protein networkhttps://string-db.org/network/9606.ENSP00000376335Integral membrane protein GPR155; G protein-coupled receptor 155.
BTBD6 protein networkhttps://string-db.org/network/9606.ENSP00000376337BTB/POZ domain-containing protein 6; Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity).
GRB2 protein networkhttps://string-db.org/network/9606.ENSP00000376345Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK fam [...]
NUDT14 protein networkhttps://string-db.org/network/9606.ENSP00000376349Uridine diphosphate glucose pyrophosphatase NUDT14; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP [...]
PDK1 protein networkhttps://string-db.org/network/9606.ENSP00000376352[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation [...]
WASF1 protein networkhttps://string-db.org/network/9606.ENSP00000376367Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...]
ADGRA1 protein networkhttps://string-db.org/network/9606.ENSP00000376384Adhesion G protein-coupled receptor A1; Orphan receptor.
RAB37 protein networkhttps://string-db.org/network/9606.ENSP00000376390Ras-related protein Rab-37; RAB37, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family.
CD300E protein networkhttps://string-db.org/network/9606.ENSP00000376395CMRF35-like molecule 2; Probably acts as an activating receptor.
CD300LB protein networkhttps://string-db.org/network/9606.ENSP00000376397CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2.
INF2 protein networkhttps://string-db.org/network/9606.ENSP00000376410Inverted formin-2; Severs actin filaments and accelerates their polymerization and depolymerization.
ARMC2 protein networkhttps://string-db.org/network/9606.ENSP00000376417Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By simi [...]
KLHL23 protein networkhttps://string-db.org/network/9606.ENSP00000376419Kelch-like protein 23; Kelch like family member 23.
SDK2 protein networkhttps://string-db.org/network/9606.ENSP00000376421Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts [...]
SPRR2A protein networkhttps://string-db.org/network/9606.ENSP00000376423Small proline rich protein 2A.
KCNJ1 protein networkhttps://string-db.org/network/9606.ENSP00000376432ATP-sensitive inward rectifier potassium channel 1; In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendenc [...]
ETS1 protein networkhttps://string-db.org/network/9606.ENSP00000376436Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival [...]
RAD9B protein networkhttps://string-db.org/network/9606.ENSP00000376440Cell cycle checkpoint control protein RAD9B; RAD9 checkpoint clamp component B.
ABCA5 protein networkhttps://string-db.org/network/9606.ENSP00000376443ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes. Belongs to the ABC transporter superfamily. ABCA family.
TIRAP protein networkhttps://string-db.org/network/9606.ENSP00000376445Toll/interleukin-1 receptor domain-containing adapter protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activa [...]
CERS6 protein networkhttps://string-db.org/network/9606.ENSP00000376453Ceramide synthase 6; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as a [...]
B3GALT1 protein networkhttps://string-db.org/network/9606.ENSP00000376456Beta-1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. [...]
ECT2 protein networkhttps://string-db.org/network/9606.ENSP00000376457Protein ECT2; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC [...]
CDON protein networkhttps://string-db.org/network/9606.ENSP00000376458Cell adhesion molecule-related/down-regulated by oncogenes; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiat [...]
GALNT3 protein networkhttps://string-db.org/network/9606.ENSP00000376465Polypeptide N-acetylgalactosaminyltransferase 3; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threon [...]
STT3A protein networkhttps://string-db.org/network/9606.ENSP00000376472Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined gl [...]
PRKAR1A protein networkhttps://string-db.org/network/9606.ENSP00000376475cAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
TRAF3 protein networkhttps://string-db.org/network/9606.ENSP00000376500TNF receptor-associated factor 3; Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling path [...]
PDCD10 protein networkhttps://string-db.org/network/9606.ENSP00000376506Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, [...]
CEP112 protein networkhttps://string-db.org/network/9606.ENSP00000376522Centrosomal protein 112.
SCN3B protein networkhttps://string-db.org/network/9606.ENSP00000376523Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its associa [...]
BAZ2B protein networkhttps://string-db.org/network/9606.ENSP00000376534Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family.
CUZD1 protein networkhttps://string-db.org/network/9606.ENSP00000376540CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a [...]
TECTA protein networkhttps://string-db.org/network/9606.ENSP00000376543Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepit [...]
CD79B protein networkhttps://string-db.org/network/9606.ENSP00000376544B-cell antigen receptor complex-associated protein beta chain; Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor comple [...]
TMEM119 protein networkhttps://string-db.org/network/9606.ENSP00000376553Transmembrane protein 119; Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and diff [...]
TMUB1 protein networkhttps://string-db.org/network/9606.ENSP00000376565Transmembrane and ubiquitin-like domain-containing protein 1; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selec [...]
MLF1 protein networkhttps://string-db.org/network/9606.ENSP00000376568Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-ind [...]
RNF208 protein networkhttps://string-db.org/network/9606.ENSP00000376572Ring finger protein 208.
RIC8B protein networkhttps://string-db.org/network/9606.ENSP00000376582Synembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP [...]
SMIM8 protein networkhttps://string-db.org/network/9606.ENSP00000376603Small integral membrane protein 8.
GTDC1 protein networkhttps://string-db.org/network/9606.ENSP00000376608Glycosyltransferase-like domain-containing protein 1; Glycosyltransferase like domain containing 1; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
GRK5 protein networkhttps://string-db.org/network/9606.ENSP00000376609G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylat [...]
TDG protein networkhttps://string-db.org/network/9606.ENSP00000376611G/T mismatch-specific thymine DNA glycosylase; DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine ( [...]
NT5DC3 protein networkhttps://string-db.org/network/9606.ENSP000003766155'-nucleotidase domain containing 3.
CSH2 protein networkhttps://string-db.org/network/9606.ENSP00000376623Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR thr [...]
IGF1 protein networkhttps://string-db.org/network/9606.ENSP00000376637Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be [...]
MAP3K19 protein networkhttps://string-db.org/network/9606.ENSP00000376647Mitogen-activated protein kinase kinase kinase 19.
EVL protein networkhttps://string-db.org/network/9606.ENSP00000376652Ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipod [...]
SYCP3 protein networkhttps://string-db.org/network/9606.ENSP00000376658Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in mal [...]
TAGLN protein networkhttps://string-db.org/network/9606.ENSP00000376678Transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence; Belongs to [...]
LCA5 protein networkhttps://string-db.org/network/9606.ENSP00000376686Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia; Belongs to the LCA5 family.
ANO4 protein networkhttps://string-db.org/network/9606.ENSP00000376703Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated c [...]
VWA2 protein networkhttps://string-db.org/network/9606.ENSP00000376708Von Willebrand factor A domain containing 2.
GIPC1 protein networkhttps://string-db.org/network/9606.ENSP00000376753PDZ domain-containing protein GIPC1; May be involved in G protein-linked signaling; Belongs to the GIPC family.
PIAS3 protein networkhttps://string-db.org/network/9606.ENSP00000376765E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...]
NKAPD1 protein networkhttps://string-db.org/network/9606.ENSP00000376767Uncharacterized protein NKAPD1; NKAP domain containing 1.
DBH protein networkhttps://string-db.org/network/9606.ENSP00000376776Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline.
POU2AF1 protein networkhttps://string-db.org/network/9606.ENSP00000376786POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, t [...]
VTI1A protein networkhttps://string-db.org/network/9606.ENSP00000376792Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are [...]
MTPN protein networkhttps://string-db.org/network/9606.ENSP00000376800Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. I [...]
DPEP1 protein networkhttps://string-db.org/network/9606.ENSP00000376807Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important rol [...]
CUL5 protein networkhttps://string-db.org/network/9606.ENSP00000376808Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5- SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degrada [...]
STEAP3 protein networkhttps://string-db.org/network/9606.ENSP00000376822Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe [...]
CYREN protein networkhttps://string-db.org/network/9606.ENSP00000376823Cell cycle regulator of non-homologous end joining; [Isoform 1]: Cell-cycle-specific inhibitor of classical non- homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S [...]
IFI27L1 protein networkhttps://string-db.org/network/9606.ENSP00000376824Interferon alpha-inducible protein 27-like protein 1; Plays a role in the apoptotic process and has a pro-apoptotic activity.
MKS1 protein networkhttps://string-db.org/network/9606.ENSP00000376827Meckel syndrome type 1 protein; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...]
BPGM protein networkhttps://string-db.org/network/9606.ENSP00000376840Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits muta [...]
PRIMA1 protein networkhttps://string-db.org/network/9606.ENSP00000376848Proline-rich membrane anchor 1; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to or [...]
CASP5 protein networkhttps://string-db.org/network/9606.ENSP00000376849Caspase-5 subunit p10; Mediator of programmed cell death (apoptosis). During non- canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune act [...]
DPP10 protein networkhttps://string-db.org/network/9606.ENSP00000376855Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipepti [...]
PDGFD protein networkhttps://string-db.org/network/9606.ENSP00000376865Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and ch [...]
NME2 protein networkhttps://string-db.org/network/9606.ENSP00000376886Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...]
NME1-NME2 protein networkhttps://string-db.org/network/9606.ENSP00000376889Nucleoside diphosphate kinase; NME1-NME2 readthrough.
IL1F10 protein networkhttps://string-db.org/network/9606.ENSP00000376893Interleukin-1 family member 10; Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T- cells in response to heat-killed C [...]
PTGFRN protein networkhttps://string-db.org/network/9606.ENSP00000376899Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity c [...]
BANP protein networkhttps://string-db.org/network/9606.ENSP00000376902Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an AT [...]
LRRIQ1 protein networkhttps://string-db.org/network/9606.ENSP00000376910Leucine rich repeats and IQ motif containing 1.
LGMN protein networkhttps://string-db.org/network/9606.ENSP00000376911Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradatio [...]
LUC7L3 protein networkhttps://string-db.org/network/9606.ENSP00000376919Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
NTNG2 protein networkhttps://string-db.org/network/9606.ENSP00000376921Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
TMCC1 protein networkhttps://string-db.org/network/9606.ENSP00000376930Transmembrane and coiled-coil domains protein 1; Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the end [...]
BCL2L11 protein networkhttps://string-db.org/network/9606.ENSP00000376943Bcl-2-like protein 11; Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less [...]
FBXW9 protein networkhttps://string-db.org/network/9606.ENSP00000376945F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
EME1 protein networkhttps://string-db.org/network/9606.ENSP00000376952Crossover junction endonuclease EME1; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Ty [...]
DENND2C protein networkhttps://string-db.org/network/9606.ENSP00000376955DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...]
BCL2L15 protein networkhttps://string-db.org/network/9606.ENSP00000376992Bcl-2-like protein 15; BCL2 like 15.
SPOP protein networkhttps://string-db.org/network/9606.ENSP00000377001Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their [...]
TSPAN8 protein networkhttps://string-db.org/network/9606.ENSP00000377003Tetraspanin-8; Tetraspanin 8.
CENPN protein networkhttps://string-db.org/network/9606.ENSP00000377007Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
PICALM protein networkhttps://string-db.org/network/9606.ENSP00000377015Phosphatidylinositol-binding clathrin assembly protein; Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internaliza [...]
TGFBRAP1 protein networkhttps://string-db.org/network/9606.ENSP00000377027Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor comple [...]
ATP5MC1 protein networkhttps://string-db.org/network/9606.ENSP00000377033ATP synthase F(0) complex subunit C1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...]
PTPA protein networkhttps://string-db.org/network/9606.ENSP00000377036Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a [...]
RASGEF1C protein networkhttps://string-db.org/network/9606.ENSP00000377037Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF).
TTLL6 protein networkhttps://string-db.org/network/9606.ENSP00000377043Tubulin polyglutamylase TTLL6; Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglut [...]
PTPRZ1 protein networkhttps://string-db.org/network/9606.ENSP00000377047Receptor-type tyrosine-protein phosphatase zeta; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal d [...]
PRCP protein networkhttps://string-db.org/network/9606.ENSP00000377055Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymati [...]
SNX11 protein networkhttps://string-db.org/network/9606.ENSP00000377059Sorting nexin-11; Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes; Belongs to the sorting nexin family.
CBX1 protein networkhttps://string-db.org/network/9606.ENSP00000377060Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) c [...]
PLXNA1 protein networkhttps://string-db.org/network/9606.ENSP00000377061Plexin-A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive [...]
RGL3 protein networkhttps://string-db.org/network/9606.ENSP00000377075Ral guanine nucleotide dissociation stimulator-like 3; Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates El [...]
LONRF2 protein networkhttps://string-db.org/network/9606.ENSP00000377086LON peptidase N-terminal domain and ring finger 2.
SLC12A8 protein networkhttps://string-db.org/network/9606.ENSP00000377112Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.
LIPT1 protein networkhttps://string-db.org/network/9606.ENSP00000377115Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA f [...]
TSGA10 protein networkhttps://string-db.org/network/9606.ENSP00000377123Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A (By similarity). Belongs to the CEP135/TSGA10 family.
AP1G1 protein networkhttps://string-db.org/network/9606.ENSP00000377148AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...]
ANKRD39 protein networkhttps://string-db.org/network/9606.ENSP00000377170Ankyrin repeat domain 39; Belongs to the ANKRD39 family.
ZNF23 protein networkhttps://string-db.org/network/9606.ENSP00000377171Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family.
SPATA7 protein networkhttps://string-db.org/network/9606.ENSP00000377176Spermatogenesis-associated protein 7; Involved in the maintenance of both rod and cone photoreceptor cells (By similarity). It is required for recruitment and proper localization of RPGRIP1 to th [...]
G6PD protein networkhttps://string-db.org/network/9606.ENSP00000377192Glucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt [...]
DBN1 protein networkhttps://string-db.org/network/9606.ENSP00000377195Drebrin; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections. Required for actin polymerization at immunological synapses (IS) and for the recruitment of [...]
HYDIN protein networkhttps://string-db.org/network/9606.ENSP00000377197Hydrocephalus-inducing protein homolog; Required for ciliary motility.
IRF2 protein networkhttps://string-db.org/network/9606.ENSP00000377218Interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses thos [...]
CDKN2D protein networkhttps://string-db.org/network/9606.ENSP00000377224Cyclin-dependent kinase 4 inhibitor D; Interacts strongly with CDK4 and CDK6 and inhibits them. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
FAM50A protein networkhttps://string-db.org/network/9606.ENSP00000377225Protein FAM50A; May be a DNA-binding protein or transcriptional factor.
ARAP1 protein networkhttps://string-db.org/network/9606.ENSP00000377233Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodel [...]
KEAP1 protein networkhttps://string-db.org/network/9606.ENSP00000377245Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for u [...]
MON2 protein networkhttps://string-db.org/network/9606.ENSP00000377250Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes.
ST3GAL2 protein networkhttps://string-db.org/network/9606.ENSP00000377257CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups [...]
SRPK2 protein networkhttps://string-db.org/network/9606.ENSP00000377262SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipep [...]
TFAP2B protein networkhttps://string-db.org/network/9606.ENSP00000377265Transcription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...]
GOLGB1 protein networkhttps://string-db.org/network/9606.ENSP00000377275Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex.
FBXO8 protein networkhttps://string-db.org/network/9606.ENSP00000377280F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).
FOLR1 protein networkhttps://string-db.org/network/9606.ENSP00000377284Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for fo [...]
SNCB protein networkhttps://string-db.org/network/9606.ENSP00000377296Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamin [...]
NUMA1 protein networkhttps://string-db.org/network/9606.ENSP00000377298Nuclear mitotic apparatus protein 1; Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes [...]
RENBP protein networkhttps://string-db.org/network/9606.ENSP00000377303N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and [...]
FDX2 protein networkhttps://string-db.org/network/9606.ENSP00000377311Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis.
DDX60 protein networkhttps://string-db.org/network/9606.ENSP00000377344Probable ATP-dependent RNA helicase DDX60; Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Bi [...]
DRD1 protein networkhttps://string-db.org/network/9606.ENSP00000377353D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family.
PDZD4 protein networkhttps://string-db.org/network/9606.ENSP00000377355PDZ domain containing 4.
ZDHHC16 protein networkhttps://string-db.org/network/9606.ENSP00000377357Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly [...]
LRRC74A protein networkhttps://string-db.org/network/9606.ENSP00000377369Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A.
IGSF11 protein networkhttps://string-db.org/network/9606.ENSP00000377370Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.
GAP43 protein networkhttps://string-db.org/network/9606.ENSP00000377372Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filop [...]
ERGIC1 protein networkhttps://string-db.org/network/9606.ENSP00000377374Endoplasmic reticulum-Golgi intermediate compartment protein 1; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family.
UBTD2 protein networkhttps://string-db.org/network/9606.ENSP00000377381Ubiquitin domain containing 2.
PSMC3IP protein networkhttps://string-db.org/network/9606.ENSP00000377384Homologous-pairing protein 2 homolog; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The co [...]
PPAN-P2RY11 protein networkhttps://string-db.org/network/9606.ENSP00000377385PPAN-P2RY11 readthrough; Belongs to the G-protein coupled receptor 1 family.
PPP6R3 protein networkhttps://string-db.org/network/9606.ENSP00000377390Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintainin [...]
GASK1B protein networkhttps://string-db.org/network/9606.ENSP00000377396Golgi associated kinase 1B; Belongs to the GASK family.
SLC35B2 protein networkhttps://string-db.org/network/9606.ENSP00000377401Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sul [...]
NDUFA4L2 protein networkhttps://string-db.org/network/9606.ENSP00000377411NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; NDUFA4 mitochondrial complex associated like 2.
SIDT1 protein networkhttps://string-db.org/network/9606.ENSP00000377416SID1 transmembrane family member 1; In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which [...]
CFAP44 protein networkhttps://string-db.org/network/9606.ENSP00000377428Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.
SUCLG1 protein networkhttps://string-db.org/network/9606.ENSP00000377446Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of [...]
MAGEA12 protein networkhttps://string-db.org/network/9606.ENSP00000377447Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines.
REG3A protein networkhttps://string-db.org/network/9606.ENSP00000377456Regenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exp [...]
CNP protein networkhttps://string-db.org/network/9606.ENSP000003774702',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
MRPL19 protein networkhttps://string-db.org/network/9606.ENSP00000377486Mitochondrial ribosomal protein L19.
EVA1A protein networkhttps://string-db.org/network/9606.ENSP00000377490Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
HMMR protein networkhttps://string-db.org/network/9606.ENSP00000377492Hyaluronan mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number [...]
TAGLN3 protein networkhttps://string-db.org/network/9606.ENSP00000377494Transgelin-3; Transgelin 3.
ZNF414 protein networkhttps://string-db.org/network/9606.ENSP00000377504Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
JUP protein networkhttps://string-db.org/network/9606.ENSP00000377508Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of [...]
SYT12 protein networkhttps://string-db.org/network/9606.ENSP00000377520Synaptotagmin-12; Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagm [...]
MOSPD3 protein networkhttps://string-db.org/network/9606.ENSP00000377522Motile sperm domain containing 3.
PTTG1 protein networkhttps://string-db.org/network/9606.ENSP00000377536Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, [...]
C1QTNF2 protein networkhttps://string-db.org/network/9606.ENSP00000377545Complement C1q tumor necrosis factor-related protein 2; Involved in the regulation of lipid metabolism in adipose tissue and liver.
KRT15 protein networkhttps://string-db.org/network/9606.ENSP00000377546Keratin, type I cytoskeletal 15; Keratin 15.
CCNJL protein networkhttps://string-db.org/network/9606.ENSP00000377547Cyclin-J-like protein; Cyclin J like.
FABP6 protein networkhttps://string-db.org/network/9606.ENSP00000377549Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By s [...]
KRT35 protein networkhttps://string-db.org/network/9606.ENSP00000377558Keratin, type I cuticular Ha5; Keratin 35; Belongs to the intermediate filament family.
LRRC29 protein networkhttps://string-db.org/network/9606.ENSP00000377561Leucine-rich repeat-containing protein 29; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.
KRT34 protein networkhttps://string-db.org/network/9606.ENSP00000377570Keratin, type I cuticular Ha4; Keratin 34.
KRTAP9-9 protein networkhttps://string-db.org/network/9606.ENSP00000377576Keratin associated protein 9-9.
BBOF1 protein networkhttps://string-db.org/network/9606.ENSP00000377577Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabili [...]
KRTAP4-12 protein networkhttps://string-db.org/network/9606.ENSP00000377582Keratin associated protein 4-12.
KRTAP2-4 protein networkhttps://string-db.org/network/9606.ENSP00000377583Keratin associated protein 2-4.
HELLS protein networkhttps://string-db.org/network/9606.ENSP00000377601Lymphoid-specific helicase; Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance [...]
KRT222 protein networkhttps://string-db.org/network/9606.ENSP00000377616Keratin-like protein KRT222; Keratin 222.
MTHFD2 protein networkhttps://string-db.org/network/9606.ENSP00000377617Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. Belongs [...]
STAMBP protein networkhttps://string-db.org/network/9606.ENSP00000377633STAM-binding protein; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in s [...]
RPL24 protein networkhttps://string-db.org/network/9606.ENSP00000377640Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family.
SENP7 protein networkhttps://string-db.org/network/9606.ENSP00000377655Sentrin-specific protease 7; Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low effici [...]
GAPVD1 protein networkhttps://string-db.org/network/9606.ENSP00000377665GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processe [...]
SUOX protein networkhttps://string-db.org/network/9606.ENSP00000377668Sulfite oxidase, mitochondrial; Sulfite oxidase.
G3BP1 protein networkhttps://string-db.org/network/9606.ENSP00000377681Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA- triggered cGAS/STING pathway by pr [...]
TTC23 protein networkhttps://string-db.org/network/9606.ENSP00000377690Tetratricopeptide repeat protein 23; Participates positively in the ciliary Hedgehog (Hh) signaling.
NIT2 protein networkhttps://string-db.org/network/9606.ENSP00000377696Omega-amidase NIT2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologic [...]
ADGRG4 protein networkhttps://string-db.org/network/9606.ENSP00000377699Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
TBC1D23 protein networkhttps://string-db.org/network/9606.ENSP00000377700TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding [...]
DGKA protein networkhttps://string-db.org/network/9606.ENSP00000377703Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kin [...]
ZSCAN25 protein networkhttps://string-db.org/network/9606.ENSP00000377708Zinc finger and SCAN domain-containing protein 25; May be involved in transcriptional regulation.
NR2F2 protein networkhttps://string-db.org/network/9606.ENSP00000377721COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or prog [...]
ORMDL3 protein networkhttps://string-db.org/network/9606.ENSP00000377724ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. Belongs to the ORM family.
ZKSCAN5 protein networkhttps://string-db.org/network/9606.ENSP00000377725Zinc finger protein with KRAB and SCAN domains 5; May be involved in transcriptional regulation.
CLDND1 protein networkhttps://string-db.org/network/9606.ENSP00000377735Claudin domain containing 1.
CHD2 protein networkhttps://string-db.org/network/9606.ENSP00000377747Chromodomain-helicase-DNA-binding protein 2; DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of his [...]
ARL13B protein networkhttps://string-db.org/network/9606.ENSP00000377769ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomp [...]
SIPA1 protein networkhttps://string-db.org/network/9606.ENSP00000377771Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound st [...]
SV2B protein networkhttps://string-db.org/network/9606.ENSP00000377779Synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells.
PROS1 protein networkhttps://string-db.org/network/9606.ENSP00000377783Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and st [...]
SYNPO protein networkhttps://string-db.org/network/9606.ENSP00000377789Synaptopodin; Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the forma [...]
PRC1 protein networkhttps://string-db.org/network/9606.ENSP00000377793Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formatio [...]
METTL7B protein networkhttps://string-db.org/network/9606.ENSP00000377796Methyltransferase-like protein 7B; Probable methyltransferase.
USP49 protein networkhttps://string-db.org/network/9606.ENSP00000377797Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a re [...]
RCCD1 protein networkhttps://string-db.org/network/9606.ENSP00000377801RCC1 domain-containing protein 1; Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possi [...]
FAM122A protein networkhttps://string-db.org/network/9606.ENSP00000377807Protein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A [...]
HDDC3 protein networkhttps://string-db.org/network/9606.ENSP00000377814Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response.
NDRG4 protein networkhttps://string-db.org/network/9606.ENSP00000377823Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell [...]
ANXA4 protein networkhttps://string-db.org/network/9606.ENSP00000377833Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis.
GPC3 protein networkhttps://string-db.org/network/9606.ENSP00000377836Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competi [...]
CACNB1 protein networkhttps://string-db.org/network/9606.ENSP00000377840Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming sub [...]
ASNS protein networkhttps://string-db.org/network/9606.ENSP00000377845Asparagine synthetase.
LHX6 protein networkhttps://string-db.org/network/9606.ENSP00000377854LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cor [...]
FAT4 protein networkhttps://string-db.org/network/9606.ENSP00000377862Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor [...]
STK26 protein networkhttps://string-db.org/network/9606.ENSP00000377867Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activatio [...]
LIPF protein networkhttps://string-db.org/network/9606.ENSP00000377900Lipase F, gastric type.
CIAPIN1 protein networkhttps://string-db.org/network/9606.ENSP00000377914Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain funct [...]
KIF7 protein networkhttps://string-db.org/network/9606.ENSP00000377934Kinesin-like protein KIF7; Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstrea [...]
PPP2R2B protein networkhttps://string-db.org/network/9606.ENSP00000377936Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the l [...]
ACTN1 protein networkhttps://string-db.org/network/9606.ENSP00000377941Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family.
UTP14A protein networkhttps://string-db.org/network/9606.ENSP00000377944U3 small nucleolar RNA-associated protein 14 homolog A; May be required for ribosome biogenesis.
QRFPR protein networkhttps://string-db.org/network/9606.ENSP00000377948Pyroglutamylated RF-amide peptide receptor; Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and int [...]
LARS1 protein networkhttps://string-db.org/network/9606.ENSP00000377954Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...]
CCT4 protein networkhttps://string-db.org/network/9606.ENSP00000377958T-complex protein 1 subunit delta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC comple [...]
GTF2F1 protein networkhttps://string-db.org/network/9606.ENSP00000377969General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration w [...]
ANKLE1 protein networkhttps://string-db.org/network/9606.ENSP00000377971Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair.
MT1X protein networkhttps://string-db.org/network/9606.ENSP00000377995Metallothionein-1X; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...]
KRIT1 protein networkhttps://string-db.org/network/9606.ENSP00000378015Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogen [...]
BAD protein networkhttps://string-db.org/network/9606.ENSP00000378040Bcl2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins [...]
FKBP2 protein networkhttps://string-db.org/network/9606.ENSP00000378046Peptidyl-prolyl cis-trans isomerase FKBP2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
TRPT1 protein networkhttps://string-db.org/network/9606.ENSP00000378050tRNA 2'-phosphotransferase 1; Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP- ribose 1''-2'' cyclic phosphate; [...]
DNASE1L3 protein networkhttps://string-db.org/network/9606.ENSP00000378053Deoxyribonuclease gamma; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to [...]
PDE8A protein networkhttps://string-db.org/network/9606.ENSP00000378056High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May b [...]
EFEMP1 protein networkhttps://string-db.org/network/9606.ENSP00000378058EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in [...]
SLFN12 protein networkhttps://string-db.org/network/9606.ENSP00000378063Schlafen family member 12; Belongs to the Schlafen family. Subgroup II subfamily.
SLFN11 protein networkhttps://string-db.org/network/9606.ENSP00000378067Schlafen family member 11; Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persisten [...]
PNPLA1 protein networkhttps://string-db.org/network/9606.ENSP00000378072Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism.
SLC28A1 protein networkhttps://string-db.org/network/9606.ENSP00000378074Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (sel [...]
PCDHGA2 protein networkhttps://string-db.org/network/9606.ENSP00000378077Protocadherin gamma-A2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
NMB protein networkhttps://string-db.org/network/9606.ENSP00000378089Neuromedin-B-32; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family.
ELOVL6 protein networkhttps://string-db.org/network/9606.ENSP00000378105Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
CCL8 protein networkhttps://string-db.org/network/9606.ENSP00000378118C-C motif chemokine 8; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind hepa [...]
STEAP2 protein networkhttps://string-db.org/network/9606.ENSP00000378119Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity); Belongs to the STEAP family.
CFI protein networkhttps://string-db.org/network/9606.ENSP00000378131Complement factor I heavy chain; Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cle [...]
IRX5 protein networkhttps://string-db.org/network/9606.ENSP00000378132Iroquois-class homeodomain protein IRX-5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell dif [...]
MCUB protein networkhttps://string-db.org/network/9606.ENSP00000378145Calcium uniporter regulatory subunit MCUb, mitochondrial; Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into t [...]
RPL34 protein networkhttps://string-db.org/network/9606.ENSP0000037816360S ribosomal protein L34; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL34 family.
ZNF207 protein networkhttps://string-db.org/network/9606.ENSP00000378165BUB3-interacting and GLEBS motif-containing protein ZNF207; Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered lo [...]
CCDC66 protein networkhttps://string-db.org/network/9606.ENSP00000378167Coiled-coil domain-containing protein 66; Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but a [...]
SGMS2 protein networkhttps://string-db.org/network/9606.ENSP00000378176Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, [...]
CEMIP protein networkhttps://string-db.org/network/9606.ENSP00000378177Cell migration-inducing and hyaluronan-binding protein; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluron [...]
BRD7 protein networkhttps://string-db.org/network/9606.ENSP00000378181Bromodomain-containing protein 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negati [...]
AIMP1 protein networkhttps://string-db.org/network/9606.ENSP00000378191Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase [...]
DMTF1 protein networkhttps://string-db.org/network/9606.ENSP00000378193Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arr [...]
GPR75 protein networkhttps://string-db.org/network/9606.ENSP00000378195Probable G-protein coupled receptor 75; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosp [...]
TBCK protein networkhttps://string-db.org/network/9606.ENSP00000378198TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and gro [...]
HSPA2 protein networkhttps://string-db.org/network/9606.ENSP00000378199Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synth [...]
AKAP5 protein networkhttps://string-db.org/network/9606.ENSP00000378207A-kinase anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle- associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association [...]
ABCC11 protein networkhttps://string-db.org/network/9606.ENSP00000378230ATP-binding cassette sub-family C member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and [...]
SFMBT1 protein networkhttps://string-db.org/network/9606.ENSP00000378235Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by c [...]
STON1-GTF2A1L protein networkhttps://string-db.org/network/9606.ENSP00000378236Stonin-1; May be involved in the endocytic machinery.
CXXC4 protein networkhttps://string-db.org/network/9606.ENSP00000378248CXXC-type zinc finger protein 4; Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1 (By similarity). Binds preferentially to DNA containing cytidine-phosphate [...]
ALG13 protein networkhttps://string-db.org/network/9606.ENSP00000378260Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13; [Isoform 1]: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities; Belon [...]
SLC9B2 protein networkhttps://string-db.org/network/9606.ENSP00000378265Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium h [...]
PAIP2 protein networkhttps://string-db.org/network/9606.ENSP00000378275Polyadenylate-binding protein-interacting protein 2; Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediate [...]
MATR3 protein networkhttps://string-db.org/network/9606.ENSP00000378284Matrin 3.
MYLK3 protein networkhttps://string-db.org/network/9606.ENSP00000378288Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity); Belongs to the pro [...]
SYNPO2L protein networkhttps://string-db.org/network/9606.ENSP00000378289Synaptopodin 2-like protein; Actin-associated protein that may play a role in modulating actin-based shape.
KRT80 protein networkhttps://string-db.org/network/9606.ENSP00000378292Keratin, type II cytoskeletal 80; Keratin 80.
INCENP protein networkhttps://string-db.org/network/9606.ENSP00000378295Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ens [...]
PPP3CB protein networkhttps://string-db.org/network/9606.ENSP00000378306Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracell [...]
SLC39A8 protein networkhttps://string-db.org/network/9606.ENSP00000378310Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain ; Belong [...]
EFCAB5 protein networkhttps://string-db.org/network/9606.ENSP00000378312EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5.
RAB3IL1 protein networkhttps://string-db.org/network/9606.ENSP00000378313Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP [...]
TTC7A protein networkhttps://string-db.org/network/9606.ENSP00000378320Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinosit [...]
PPP3CA protein networkhttps://string-db.org/network/9606.ENSP00000378323Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracel [...]
DNAJA4 protein networkhttps://string-db.org/network/9606.ENSP00000378324DnaJ heat shock protein family member A4.
ZP3 protein networkhttps://string-db.org/network/9606.ENSP00000378326Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and [...]
ANKRD13B protein networkhttps://string-db.org/network/9606.ENSP00000378328Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...]
TGFB1I1 protein networkhttps://string-db.org/network/9606.ENSP00000378332Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleu [...]
GIT1 protein networkhttps://string-db.org/network/9606.ENSP00000378338ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling ves [...]
COL4A6 protein networkhttps://string-db.org/network/9606.ENSP00000378340Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
CDC23 protein networkhttps://string-db.org/network/9606.ENSP00000378350Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
KIF20A protein networkhttps://string-db.org/network/9606.ENSP00000378356Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the centra [...]
ADH6 protein networkhttps://string-db.org/network/9606.ENSP00000378359Alcohol dehydrogenase 6.
TKFC protein networkhttps://string-db.org/network/9606.ENSP00000378360ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is [...]
SLC11A2 protein networkhttps://string-db.org/network/9606.ENSP00000378364Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical [...]
CCL26 protein networkhttps://string-db.org/network/9606.ENSP00000378365C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils.
NRG4 protein networkhttps://string-db.org/network/9606.ENSP00000378367Pro-neuregulin-4, membrane-bound isoform; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine p [...]
FLOT2 protein networkhttps://string-db.org/network/9606.ENSP00000378368Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion [...]
PSAP protein networkhttps://string-db.org/network/9606.ENSP00000378394Saposin-B-Val; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Sap [...]
WDR89 protein networkhttps://string-db.org/network/9606.ENSP00000378399WD repeat domain 89.
LIMA1 protein networkhttps://string-db.org/network/9606.ENSP00000378400LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ru [...]
SPOCK1 protein networkhttps://string-db.org/network/9606.ENSP00000378401Testican-1; May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
SIN3A protein networkhttps://string-db.org/network/9606.ENSP00000378402Paired amphipathic helix protein Sin3a; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Als [...]
BCKDK protein networkhttps://string-db.org/network/9606.ENSP00000378405[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regul [...]
GPT protein networkhttps://string-db.org/network/9606.ENSP00000378408Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liv [...]
VSIR protein networkhttps://string-db.org/network/9606.ENSP00000378409V-type immunoglobulin domain-containing suppressor of T-cell activation; Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhi [...]
SMARCD1 protein networkhttps://string-db.org/network/9606.ENSP00000378414SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...]
ALAS1 protein networkhttps://string-db.org/network/9606.ENSP000003784165-aminolevulinate synthase, nonspecific, mitochondrial; 5'-aminolevulinate synthase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
SP9 protein networkhttps://string-db.org/network/9606.ENSP00000378418Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgro [...]
VKORC1 protein networkhttps://string-db.org/network/9606.ENSP00000378426Vitamin K epoxide reductase complex subunit 1; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide t [...]
C5orf24 protein networkhttps://string-db.org/network/9606.ENSP00000378427UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family.
MMRN1 protein networkhttps://string-db.org/network/9606.ENSP00000378431155 kDa platelet multimerin; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet act [...]
CPLX3 protein networkhttps://string-db.org/network/9606.ENSP00000378464Complexin-3; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By simil [...]
CDKL4 protein networkhttps://string-db.org/network/9606.ENSP00000378476Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4.
RGS19 protein networkhttps://string-db.org/network/9606.ENSP00000378483Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G [...]
MATK protein networkhttps://string-db.org/network/9606.ENSP00000378485Megakaryocyte-associated tyrosine-protein kinase; Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in [...]
VDAC1 protein networkhttps://string-db.org/network/9606.ENSP00000378487Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows [...]
CYP1A1 protein networkhttps://string-db.org/network/9606.ENSP00000378488Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molec [...]
GRM2 protein networkhttps://string-db.org/network/9606.ENSP00000378492Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
ZBTB9 protein networkhttps://string-db.org/network/9606.ENSP00000378503Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation.
NXF3 protein networkhttps://string-db.org/network/9606.ENSP00000378504Nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor.
CLK3 protein networkhttps://string-db.org/network/9606.ENSP00000378505Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the sp [...]
OR10W1 protein networkhttps://string-db.org/network/9606.ENSP00000378516Olfactory receptor 10W1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SPP1 protein networkhttps://string-db.org/network/9606.ENSP00000378517Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
FZR1 protein networkhttps://string-db.org/network/9606.ENSP00000378529Fizzy-related protein homolog; Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in r [...]
MEPE protein networkhttps://string-db.org/network/9606.ENSP00000378534Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization [...]
ZBTB46 protein networkhttps://string-db.org/network/9606.ENSP00000378536Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1.
GPR135 protein networkhttps://string-db.org/network/9606.ENSP00000378548G-protein coupled receptor 135; Orphan receptor. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely t [...]
DAAM1 protein networkhttps://string-db.org/network/9606.ENSP00000378557Disheveled-associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho- [...]
PFDN6 protein networkhttps://string-db.org/network/9606.ENSP00000378563Prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
SULT1A3 protein networkhttps://string-db.org/network/9606.ENSP00000378570Sulfotransferase family 1A member 3.
CLDN3 protein networkhttps://string-db.org/network/9606.ENSP00000378577Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
AFF1 protein networkhttps://string-db.org/network/9606.ENSP00000378578AF4/FMR2 family member 1.
TIMM9 protein networkhttps://string-db.org/network/9606.ENSP00000378588Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mit [...]
DNAJC30 protein networkhttps://string-db.org/network/9606.ENSP00000378605DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthas [...]
ARHGAP24 protein networkhttps://string-db.org/network/9606.ENSP00000378611Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by con [...]
HERC4 protein networkhttps://string-db.org/network/9606.ENSP00000378624Probable E3 ubiquitin-protein ligase HERC4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon ma [...]
DRP2 protein networkhttps://string-db.org/network/9606.ENSP00000378635Dystrophin-related protein 2; Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX l [...]
ZNF785 protein networkhttps://string-db.org/network/9606.ENSP00000378642Zinc finger protein 785; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TBX6 protein networkhttps://string-db.org/network/9606.ENSP00000378650T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulatin [...]
POM121 protein networkhttps://string-db.org/network/9606.ENSP00000378687Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to [...]
CALN1 protein networkhttps://string-db.org/network/9606.ENSP00000378690Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of ne [...]
CDK1 protein networkhttps://string-db.org/network/9606.ENSP00000378699Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 pro [...]
BRD2 protein networkhttps://string-db.org/network/9606.ENSP00000378702Bromodomain-containing protein 2; May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, prob [...]
FAM135B protein networkhttps://string-db.org/network/9606.ENSP00000378710Protein FAM135B; Family with sequence similarity 135 member B.
IZUMO4 protein networkhttps://string-db.org/network/9606.ENSP00000378712Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family.
SEC31A protein networkhttps://string-db.org/network/9606.ENSP00000378721Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
KTN1 protein networkhttps://string-db.org/network/9606.ENSP00000378725Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the ki [...]
ALDOC protein networkhttps://string-db.org/network/9606.ENSP00000378731Aldolase, fructose-bisphosphate C.
LBH protein networkhttps://string-db.org/network/9606.ENSP00000378733Protein LBH; Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway; Belongs to the LBH family.
CRCP protein networkhttps://string-db.org/network/9606.ENSP00000378736DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
AK4 protein networkhttps://string-db.org/network/9606.ENSP00000378743Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and d [...]
SLC16A9 protein networkhttps://string-db.org/network/9606.ENSP00000378757Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.
MVP protein networkhttps://string-db.org/network/9606.ENSP00000378760Major vault protein; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role i [...]
PPP1CB protein networkhttps://string-db.org/network/9606.ENSP00000378769Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hu [...]
QPRT protein networkhttps://string-db.org/network/9606.ENSP00000378782Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA).
PHF20L1 protein networkhttps://string-db.org/network/9606.ENSP00000378784PHD finger protein 20 like 1.
HLA-DRA protein networkhttps://string-db.org/network/9606.ENSP00000378786HLA class II histocompatibility antigen, DR alpha chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surfa [...]
ZNF169 protein networkhttps://string-db.org/network/9606.ENSP00000378792Zinc finger protein 169; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PAQR5 protein networkhttps://string-db.org/network/9606.ENSP00000378803Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation.
CHCHD2 protein networkhttps://string-db.org/network/9606.ENSP00000378812Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4 [...]
QRICH1 protein networkhttps://string-db.org/network/9606.ENSP00000378830Glutamine-rich protein 1; Glutamine rich 1.
LAT protein networkhttps://string-db.org/network/9606.ENSP00000378845Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCG [...]
MAPK1IP1L protein networkhttps://string-db.org/network/9606.ENSP00000378851MAPK-interacting and spindle-stabilizing protein-like; Mitogen-activated protein kinase 1 interacting protein 1 like.
PSPH protein networkhttps://string-db.org/network/9606.ENSP00000378854Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates; Belong [...]
LGALS9 protein networkhttps://string-db.org/network/9606.ENSP00000378856Galectin-9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bacte [...]
WDR6 protein networkhttps://string-db.org/network/9606.ENSP00000378857WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.
A1CF protein networkhttps://string-db.org/network/9606.ENSP00000378868APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA cod [...]
AGPAT1 protein networkhttps://string-db.org/network/9606.ENSP000003788771-acyl-sn-glycerol-3-phosphate acyltransferase alpha; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by i [...]
ZNF484 protein networkhttps://string-db.org/network/9606.ENSP00000378881Zinc finger protein 484; May be involved in transcriptional regulation.
DHRS7B protein networkhttps://string-db.org/network/9606.ENSP00000378887Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
EGFL8 protein networkhttps://string-db.org/network/9606.ENSP00000378888Epidermal growth factor-like protein 8; EGF like domain multiple 8.
ASAH2 protein networkhttps://string-db.org/network/9606.ENSP00000378897Neutral ceramidase soluble form; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphoryla [...]
COBL protein networkhttps://string-db.org/network/9606.ENSP00000378912Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite bra [...]
ULK2 protein networkhttps://string-db.org/network/9606.ENSP00000378914Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the format [...]
ATXN2L protein networkhttps://string-db.org/network/9606.ENSP00000378917Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation.
SLC26A6 protein networkhttps://string-db.org/network/9606.ENSP00000378920Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeosta [...]
PPHLN1 protein networkhttps://string-db.org/network/9606.ENSP00000378935Periphilin-1; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to [...]
MFAP4 protein networkhttps://string-db.org/network/9606.ENSP00000378957Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance.
RABL2B protein networkhttps://string-db.org/network/9606.ENSP00000378958Rab-like protein 2B; Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability. Inv [...]
SNTB1 protein networkhttps://string-db.org/network/9606.ENSP00000378965Beta-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and th [...]
SULT1A1 protein networkhttps://string-db.org/network/9606.ENSP00000378972Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransm [...]
MAPK8 protein networkhttps://string-db.org/network/9606.ENSP00000378974Mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. [...]
SULT1A2 protein networkhttps://string-db.org/network/9606.ENSP00000378992Sulfotransferase 1A2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransm [...]
NREP protein networkhttps://string-db.org/network/9606.ENSP00000378996Neuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functio [...]
NUPR1 protein networkhttps://string-db.org/network/9606.ENSP00000379003Nuclear protein 1; Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvir [...]
SLC5A10 protein networkhttps://string-db.org/network/9606.ENSP00000379008Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) f [...]
CPT1B protein networkhttps://string-db.org/network/9606.ENSP00000379011Carnitine O-palmitoyltransferase 1, muscle isoform; Carnitine palmitoyltransferase 1B.
FBXW10 protein networkhttps://string-db.org/network/9606.ENSP00000379025F-box/WD repeat-containing protein 10; Probable substrate-recognition component of a SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subseque [...]
TRIM16L protein networkhttps://string-db.org/network/9606.ENSP00000379030Tripartite motif-containing protein 16-like protein; Tripartite motif containing 16 like; Belongs to the TRIM/RBCC family.
EXT2 protein networkhttps://string-db.org/network/9606.ENSP00000379032Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appe [...]
TYMP protein networkhttps://string-db.org/network/9606.ENSP00000379038Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activit [...]
ERO1A protein networkhttps://string-db.org/network/9606.ENSP00000379042ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in o [...]
CCDC51 protein networkhttps://string-db.org/network/9606.ENSP00000379047Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria th [...]
PURB protein networkhttps://string-db.org/network/9606.ENSP00000379051Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene [...]
MIEF2 protein networkhttps://string-db.org/network/9606.ENSP00000379057Mitochondrial dynamics protein MID49; Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and as [...]
TRPS1 protein networkhttps://string-db.org/network/9606.ENSP00000379065Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate [...]
EHMT2 protein networkhttps://string-db.org/network/9606.ENSP00000379078Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me repre [...]
ADM2 protein networkhttps://string-db.org/network/9606.ENSP00000379087Adrenomedullin-2; [Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the [...]
BTC protein networkhttps://string-db.org/network/9606.ENSP00000379092Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
AREG protein networkhttps://string-db.org/network/9606.ENSP00000379097Amphiregulin; Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts; Belongs to the a [...]
CAMK2B protein networkhttps://string-db.org/network/9606.ENSP00000379098Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, [...]
MTHFD2L protein networkhttps://string-db.org/network/9606.ENSP00000379108Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like.
CXCL1 protein networkhttps://string-db.org/network/9606.ENSP00000379110Growth-regulated alpha protein; Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the proces [...]
IL4R protein networkhttps://string-db.org/network/9606.ENSP00000379111Soluble interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiat [...]
APIP protein networkhttps://string-db.org/network/9606.ENSP00000379133Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the me [...]
AFP protein networkhttps://string-db.org/network/9606.ENSP00000379138Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding pr [...]
CXCL12 protein networkhttps://string-db.org/network/9606.ENSP00000379140Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the [...]
ZNF32 protein networkhttps://string-db.org/network/9606.ENSP00000379143Zinc finger protein 32; May be involved in transcriptional regulation.
TNRC6A protein networkhttps://string-db.org/network/9606.ENSP00000379144Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent repres [...]
MPRIP protein networkhttps://string-db.org/network/9606.ENSP00000379156Myosin phosphatase Rho-interacting protein; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an in [...]
ZNF287 protein networkhttps://string-db.org/network/9606.ENSP00000379169Zinc finger protein 287; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TRABD protein networkhttps://string-db.org/network/9606.ENSP00000379173TraB domain-containing protein; TraB domain containing.
POLM protein networkhttps://string-db.org/network/9606.ENSP00000379174DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain ge [...]
CDKL1 protein networkhttps://string-db.org/network/9606.ENSP00000379176Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
RAE1 protein networkhttps://string-db.org/network/9606.ENSP00000379181mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cyt [...]
PANX2 protein networkhttps://string-db.org/network/9606.ENSP00000379183Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.
VCPKMT protein networkhttps://string-db.org/network/9606.ENSP00000379201Protein-lysine methyltransferase METTL21D; Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity; Belongs to [...]
BMP7 protein networkhttps://string-db.org/network/9606.ENSP00000379204Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...]
ZNF248 protein networkhttps://string-db.org/network/9606.ENSP00000379208Zinc finger protein 248; May be involved in transcriptional regulation.
PODN protein networkhttps://string-db.org/network/9606.ENSP00000379212Podocan; Negatively regulates cell proliferation and cell migration. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily.
UBFD1 protein networkhttps://string-db.org/network/9606.ENSP00000379217Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator.
COA1 protein networkhttps://string-db.org/network/9606.ENSP00000379218Cytochrome c oxidase assembly factor 1 homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytoch [...]
TEX11 protein networkhttps://string-db.org/network/9606.ENSP00000379226Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
HECW1 protein networkhttps://string-db.org/network/9606.ENSP00000379228E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotroph [...]
LRRC2 protein networkhttps://string-db.org/network/9606.ENSP00000379241Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2.
CDRT1 protein networkhttps://string-db.org/network/9606.ENSP00000379242CMT1A duplicated region transcript 1.
NCALD protein networkhttps://string-db.org/network/9606.ENSP00000379256Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions; Belongs to the recoverin family.
GLI3 protein networkhttps://string-db.org/network/9606.ENSP00000379258Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 [...]
TEKT3 protein networkhttps://string-db.org/network/9606.ENSP00000379263Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility.
ELP4 protein networkhttps://string-db.org/network/9606.ENSP00000379267Elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in trans [...]
ABHD16A protein networkhttps://string-db.org/network/9606.ENSP00000379282Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a cl [...]
YWHAZ protein networkhttps://string-db.org/network/9606.ENSP0000037928714-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by rec [...]
BCAS1 protein networkhttps://string-db.org/network/9606.ENSP00000379290Breast carcinoma-amplified sequence 1; Required for myelination.
FAM172A protein networkhttps://string-db.org/network/9606.ENSP00000379294Cotranscriptional regulator FAM172A; Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions a [...]
CASC1 protein networkhttps://string-db.org/network/9606.ENSP00000379310Protein CASC1.
SLC5A12 protein networkhttps://string-db.org/network/9606.ENSP00000379326Sodium-coupled monocarboxylate transporter 2; Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma mem [...]
NFATC2 protein networkhttps://string-db.org/network/9606.ENSP00000379330Nuclear factor of activated T-cells, cytoplasmic 2; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF [...]
RPS29 protein networkhttps://string-db.org/network/9606.ENSP00000379339Ribosomal protein S29.
ITGB1 protein networkhttps://string-db.org/network/9606.ENSP00000379350Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydrox [...]
ST8SIA1 protein networkhttps://string-db.org/network/9606.ENSP00000379353Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one [...]
MOB1A protein networkhttps://string-db.org/network/9606.ENSP00000379364MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apop [...]
EDA2R protein networkhttps://string-db.org/network/9606.ENSP00000379365Tumor necrosis factor receptor superfamily member 27; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be m [...]
MOB1B protein networkhttps://string-db.org/network/9606.ENSP00000379366MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apop [...]
LYRM1 protein networkhttps://string-db.org/network/9606.ENSP00000379367LYR motif-containing protein 1; May promote cell proliferation and inhibition of apoptosis of preadipocytes; Belongs to the complex I LYR family.
ZNF35 protein networkhttps://string-db.org/network/9606.ENSP00000379368Zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FOXB1 protein networkhttps://string-db.org/network/9606.ENSP00000379369Forkhead box B1.
GTF2A2 protein networkhttps://string-db.org/network/9606.ENSP00000379372Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a compl [...]
GCNT3 protein networkhttps://string-db.org/network/9606.ENSP00000379377Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and [...]
ENAM protein networkhttps://string-db.org/network/9606.ENSP00000379383Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation.
ZNF445 protein networkhttps://string-db.org/network/9606.ENSP00000379387Zinc finger protein 445; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner [...]
HERPUD2 protein networkhttps://string-db.org/network/9606.ENSP00000379390Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway.
THUMPD1 protein networkhttps://string-db.org/network/9606.ENSP00000379392THUMP domain-containing protein 1; Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation.
NAV2 protein networkhttps://string-db.org/network/9606.ENSP00000379396Neuron navigator 2; Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs; Belongs to the Na [...]
ODAM protein networkhttps://string-db.org/network/9606.ENSP00000379401Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the [...]
NDUFAF6 protein networkhttps://string-db.org/network/9606.ENSP00000379430NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the [...]
UMOD protein networkhttps://string-db.org/network/9606.ENSP00000379438Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes [...]
JMY protein networkhttps://string-db.org/network/9606.ENSP00000379441Junction-mediating and -regulatory protein; Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that inc [...]
FAF1 protein networkhttps://string-db.org/network/9606.ENSP00000379457FAS-associated factor 1; Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but canno [...]
ZNF586 protein networkhttps://string-db.org/network/9606.ENSP00000379458Zinc finger protein 586; May be involved in transcriptional regulation.
ZNF134 protein networkhttps://string-db.org/network/9606.ENSP00000379464Zinc finger protein 134; May be involved in transcriptional regulation.
CCK protein networkhttps://string-db.org/network/9606.ENSP00000379472Cholecystokinin-58 desnonopeptide; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A [...]
PDE1C protein networkhttps://string-db.org/network/9606.ENSP00000379496Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP [...]
UEVLD protein networkhttps://string-db.org/network/9606.ENSP00000379500Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily.
PDP1 protein networkhttps://string-db.org/network/9606.ENSP00000379503[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate [...]
RPL14 protein networkhttps://string-db.org/network/9606.ENSP0000037950660S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family.
MGST1 protein networkhttps://string-db.org/network/9606.ENSP00000379512Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.
TMC5 protein networkhttps://string-db.org/network/9606.ENSP00000379531Transmembrane channel-like protein 5; Probable ion channel.
TSPO protein networkhttps://string-db.org/network/9606.ENSP00000379563Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes [...]
CCHCR1 protein networkhttps://string-db.org/network/9606.ENSP00000379566Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation.
MRGPRX3 protein networkhttps://string-db.org/network/9606.ENSP00000379571Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...]
RAB27A protein networkhttps://string-db.org/network/9606.ENSP00000379601Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis [...]
VAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000379602Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane; Belongs to the synaptobrevin family.
TAX1BP1 protein networkhttps://string-db.org/network/9606.ENSP00000379612Tax1-binding protein 1; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a ro [...]
MYH11 protein networkhttps://string-db.org/network/9606.ENSP00000379616Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
WDR72 protein networkhttps://string-db.org/network/9606.ENSP00000379619WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and c [...]
SNX16 protein networkhttps://string-db.org/network/9606.ENSP00000379621Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome [...]
NDE1 protein networkhttps://string-db.org/network/9606.ENSP00000379643Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regul [...]
SOX6 protein networkhttps://string-db.org/network/9606.ENSP00000379644Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleto [...]
LILRA6 protein networkhttps://string-db.org/network/9606.ENSP00000379651Leukocyte immunoglobulin-like receptor subfamily A member 6; May act as receptor for class I MHC antigens.
MARF1 protein networkhttps://string-db.org/network/9606.ENSP00000379654Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which i [...]
ETV6 protein networkhttps://string-db.org/network/9606.ENSP00000379658Transcription factor ETV6; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation; Belongs to the ETS family.
MPV17L protein networkhttps://string-db.org/network/9606.ENSP00000379669Mpv17-like protein; Isoform 1 participates in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes. Belongs to the peroxisomal membrane protein PXMP2/4 [...]
PGM5 protein networkhttps://string-db.org/network/9606.ENSP00000379678Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity.
NAGA protein networkhttps://string-db.org/network/9606.ENSP00000379680Alpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
PRH2 protein networkhttps://string-db.org/network/9606.ENSP00000379682Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental ena [...]
CYP19A1 protein networkhttps://string-db.org/network/9606.ENSP00000379683Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, [...]
ZNF813 protein networkhttps://string-db.org/network/9606.ENSP00000379684Zinc finger protein 813; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF765 protein networkhttps://string-db.org/network/9606.ENSP00000379689Zinc finger protein 765; May be involved in transcriptional regulation.
PDXDC1 protein networkhttps://string-db.org/network/9606.ENSP00000379691Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family.
PKIA protein networkhttps://string-db.org/network/9606.ENSP00000379696cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme af [...]
ZNF665 protein networkhttps://string-db.org/network/9606.ENSP00000379702Zinc finger protein 665; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ARHGAP21 protein networkhttps://string-db.org/network/9606.ENSP00000379709Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also requ [...]
USP8 protein networkhttps://string-db.org/network/9606.ENSP00000379721Ubiquitin carboxyl-terminal hydrolase 8; Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventi [...]
CEACAM18 protein networkhttps://string-db.org/network/9606.ENSP00000379738CEA cell adhesion molecule 18; Belongs to the immunoglobulin superfamily. CEA family.
IPP protein networkhttps://string-db.org/network/9606.ENSP00000379739Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton.
CCDC125 protein networkhttps://string-db.org/network/9606.ENSP00000379754Coiled-coil domain-containing protein 125; May be involved in the regulation of cell migration.
ZC3H7A protein networkhttps://string-db.org/network/9606.ENSP00000379773Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'- ATA(A/T)-5' motif in the [...]
COX7B2 protein networkhttps://string-db.org/network/9606.ENSP00000379784Cytochrome c oxidase subunit 7B2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The r [...]
AMPD3 protein networkhttps://string-db.org/network/9606.ENSP00000379802AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
OSBPL10 protein networkhttps://string-db.org/network/9606.ENSP00000379804Oxysterol-binding protein-related protein 10; Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphat [...]
ATF7IP2 protein networkhttps://string-db.org/network/9606.ENSP00000379808Activating transcription factor 7-interacting protein 2; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chrom [...]
COL4A3 protein networkhttps://string-db.org/network/9606.ENSP00000379823Collagen alpha-3(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
TRIM40 protein networkhttps://string-db.org/network/9606.ENSP00000379826Tripartite motif-containing protein 40; May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of [...]
SLC30A5 protein networkhttps://string-db.org/network/9606.ENSP00000379836Zinc transporter 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 [...]
CARHSP1 protein networkhttps://string-db.org/network/9606.ENSP00000379838Calcium-regulated heat-stable protein 1; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).
GNE protein networkhttps://string-db.org/network/9606.ENSP00000379839Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essenti [...]
GPS2 protein networkhttps://string-db.org/network/9606.ENSP00000379841G protein pathway suppressor 2; Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, [...]
SGK3 protein networkhttps://string-db.org/network/9606.ENSP00000379842Serine/threonine-protein kinase Sgk3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, sur [...]
ABAT protein networkhttps://string-db.org/network/9606.ENSP000003798454-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respective [...]
ZNF143 protein networkhttps://string-db.org/network/9606.ENSP00000379847Zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in effic [...]
ADHFE1 protein networkhttps://string-db.org/network/9606.ENSP00000379865Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of [...]
COL4A4 protein networkhttps://string-db.org/network/9606.ENSP00000379866Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...]
ELP5 protein networkhttps://string-db.org/network/9606.ENSP00000379869Elongator complex protein 5; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in trans [...]
HLA-A protein networkhttps://string-db.org/network/9606.ENSP00000379873HLA class I histocompatibility antigen, A alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily vir [...]
LRRC3B protein networkhttps://string-db.org/network/9606.ENSP00000379880Leucine-rich repeat-containing protein 3B; Leucine rich repeat containing 3B.
RPS8 protein networkhttps://string-db.org/network/9606.ENSP00000379888Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family.
AP1S3 protein networkhttps://string-db.org/network/9606.ENSP00000379891AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...]
GATM protein networkhttps://string-db.org/network/9606.ENSP00000379895Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. [...]
ARL4A protein networkhttps://string-db.org/network/9606.ENSP00000379898ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...]
TMEM106B protein networkhttps://string-db.org/network/9606.ENSP00000379901Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lys [...]
THRB protein networkhttps://string-db.org/network/9606.ENSP00000379904Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyr [...]
CENPK protein networkhttps://string-db.org/network/9606.ENSP00000379911Centromere protein K; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...]
ATN1 protein networkhttps://string-db.org/network/9606.ENSP00000379915Atrophin-1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcription [...]
UBE2E2 protein networkhttps://string-db.org/network/9606.ENSP00000379931Ubiquitin-conjugating enzyme E2 E2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'- [...]
ZDHHC4 protein networkhttps://string-db.org/network/9606.ENSP00000379934Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type palmitoyltransferase 4.
BICRA protein networkhttps://string-db.org/network/9606.ENSP00000379946BRD4-interacting chromatin-remodeling complex-associated protein; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure [...]
STK16 protein networkhttps://string-db.org/network/9606.ENSP00000379964Serine/threonine-protein kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphor [...]
ILK protein networkhttps://string-db.org/network/9606.ENSP00000379975Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein p [...]
GAPT protein networkhttps://string-db.org/network/9606.ENSP00000379997Protein GAPT; Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). [...]
TIMM17B protein networkhttps://string-db.org/network/9606.ENSP00000379999Mitochondrial import inner membrane translocase subunit Tim17-B; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across [...]
LTB4R protein networkhttps://string-db.org/network/9606.ENSP00000380008Leukotriene B4 receptor 1; Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger sys [...]
ZNF384 protein networkhttps://string-db.org/network/9606.ENSP00000380019Zinc finger protein 384; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity); Belongs to [...]
OR12D3 protein networkhttps://string-db.org/network/9606.ENSP00000380023Olfactory receptor 12D3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ING4 protein networkhttps://string-db.org/network/9606.ENSP00000380024Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of hi [...]
DHRS1 protein networkhttps://string-db.org/network/9606.ENSP00000380027Dehydrogenase/reductase SDR family member 1; Dehydrogenase/reductase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
DDX17 protein networkhttps://string-db.org/network/9606.ENSP00000380033Probable ATP-dependent RNA helicase DDX17; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRN [...]
FITM2 protein networkhttps://string-db.org/network/9606.ENSP00000380037Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization; Belongs to th [...]
CSNK1E protein networkhttps://string-db.org/network/9606.ENSP00000380044Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of p [...]
LEUTX protein networkhttps://string-db.org/network/9606.ENSP00000380053Leucine twenty homeobox.
EAF1 protein networkhttps://string-db.org/network/9606.ENSP00000380054ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family.
ZSCAN32 protein networkhttps://string-db.org/network/9606.ENSP00000380061Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GAPDH protein networkhttps://string-db.org/network/9606.ENSP00000380070Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. P [...]
TIGD7 protein networkhttps://string-db.org/network/9606.ENSP00000380071Tigger transposable element derived 7; Belongs to the tigger transposable element derived protein family.
IRF9 protein networkhttps://string-db.org/network/9606.ENSP00000380073Interferon regulatory factor 9; Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and [...]
SLC38A9 protein networkhttps://string-db.org/network/9606.ENSP00000380074Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of t [...]
SLC29A4 protein networkhttps://string-db.org/network/9606.ENSP00000380081Equilibrative nucleoside transporter 4; Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenyl [...]
ZNF213 protein networkhttps://string-db.org/network/9606.ENSP00000380087Zinc finger protein 213; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SOX10 protein networkhttps://string-db.org/network/9606.ENSP00000380093Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturatio [...]
NFKBID protein networkhttps://string-db.org/network/9606.ENSP00000380109NF-kappa-B inhibitor delta; Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved [...]
RBAK-RBAKDN protein networkhttps://string-db.org/network/9606.ENSP00000380112RBAK-RBAKDN readthrough.
PROSER3 protein networkhttps://string-db.org/network/9606.ENSP00000380116Proline and serine rich 3.
RBAK protein networkhttps://string-db.org/network/9606.ENSP00000380120RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription.
CLDN6 protein networkhttps://string-db.org/network/9606.ENSP00000380131Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family.
CARD11 protein networkhttps://string-db.org/network/9606.ENSP00000380150Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell prolifera [...]
OR51E2 protein networkhttps://string-db.org/network/9606.ENSP00000380153Olfactory receptor 51E2; Olfactory receptor. Activated by the odorant, beta-ionone, a synthetic terpenoid. The activity of this receptor is propably mediated by G-proteins leading to the elevatio [...]
OR51E1 protein networkhttps://string-db.org/network/9606.ENSP00000380155Olfactory receptor 51E1; Odorant receptor.
MOCS2 protein networkhttps://string-db.org/network/9606.ENSP00000380157Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the [...]
FLYWCH2 protein networkhttps://string-db.org/network/9606.ENSP00000380159FLYWCH family member 2.
ZNF182 protein networkhttps://string-db.org/network/9606.ENSP00000380165Zinc finger protein 182; May be involved in transcriptional regulation.
ZSCAN29 protein networkhttps://string-db.org/network/9606.ENSP00000380174Zinc finger and SCAN domain-containing protein 29; May be involved in transcriptional regulation.
UBE2G1 protein networkhttps://string-db.org/network/9606.ENSP00000380178Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as [...]
GPAT4 protein networkhttps://string-db.org/network/9606.ENSP00000380184Glycerol-3-phosphate acyltransferase 4; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the [...]
PLEKHG6 protein networkhttps://string-db.org/network/9606.ENSP00000380185Pleckstrin homology domain-containing family G member 6; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHO [...]
ITGA4 protein networkhttps://string-db.org/network/9606.ENSP00000380227Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of f [...]
NUDT1 protein networkhttps://string-db.org/network/9606.ENSP000003802417,8-dihydro-8-oxoguanine triphosphatase; Antimutagenic. Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools. Acts as a sanitizing enzyme for oxidized nucleoti [...]
HRH1 protein networkhttps://string-db.org/network/9606.ENSP00000380247Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal [...]
SLC17A3 protein networkhttps://string-db.org/network/9606.ENSP00000380250Sodium-dependent phosphate transport protein 4; [Isoform 2]: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-be [...]
NUDT19 protein networkhttps://string-db.org/network/9606.ENSP00000380251Nucleoside diphosphate-linked moiety X motif 19; Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA ester [...]
NFE2L2 protein networkhttps://string-db.org/network/9606.ENSP00000380252Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter r [...]
CCNF protein networkhttps://string-db.org/network/9606.ENSP00000380256Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 [...]
RAPGEF4 protein networkhttps://string-db.org/network/9606.ENSP00000380271Rap guanine nucleotide exchange factor 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involve [...]
GPER1 protein networkhttps://string-db.org/network/9606.ENSP00000380281G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17-beta- estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracel [...]
GPR146 protein networkhttps://string-db.org/network/9606.ENSP00000380283Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
C7orf50 protein networkhttps://string-db.org/network/9606.ENSP00000380286Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50.
JPH4 protein networkhttps://string-db.org/network/9606.ENSP00000380307Junctophilin-4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...]
DYNC1I2 protein networkhttps://string-db.org/network/9606.ENSP00000380308Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargo [...]
ZNF676 protein networkhttps://string-db.org/network/9606.ENSP00000380310Zinc finger protein 676; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF208 protein networkhttps://string-db.org/network/9606.ENSP00000380315Zinc finger protein 208; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TULP3 protein networkhttps://string-db.org/network/9606.ENSP00000380321Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment o [...]
EMC6 protein networkhttps://string-db.org/network/9606.ENSP00000380322ER membrane protein complex subunit 6; Belongs to the EMC6 family.
ITIH5 protein networkhttps://string-db.org/network/9606.ENSP00000380333Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor.
NCF4 protein networkhttps://string-db.org/network/9606.ENSP00000380334Neutrophil cytosol factor 4; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, [...]
SMU1 protein networkhttps://string-db.org/network/9606.ENSP00000380336WD40 repeat-containing protein SMU1, N-terminally processed; Involved in pre-mRNA splicing as a component of the spliceosome. Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). [...]
CAPN3 protein networkhttps://string-db.org/network/9606.ENSP00000380349Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.
ZNF682 protein networkhttps://string-db.org/network/9606.ENSP00000380351Zinc finger protein 682; May be involved in transcriptional regulation.
DDHD2 protein networkhttps://string-db.org/network/9606.ENSP00000380352Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidyli [...]
SFMBT2 protein networkhttps://string-db.org/network/9606.ENSP00000380353Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene.
RGN protein networkhttps://string-db.org/network/9606.ENSP00000380365Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in [...]
MYH2 protein networkhttps://string-db.org/network/9606.ENSP00000380367Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity).
PAFAH1B1 protein networkhttps://string-db.org/network/9606.ENSP00000380378Platelet-activating factor acetylhydrolase IB subunit alpha; Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmi [...]
WNT5B protein networkhttps://string-db.org/network/9606.ENSP00000380379Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...]
FOXRED2 protein networkhttps://string-db.org/network/9606.ENSP00000380401FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endo [...]
AGAP3 protein networkhttps://string-db.org/network/9606.ENSP00000380413Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation o [...]
IL15RA protein networkhttps://string-db.org/network/9606.ENSP00000380421Soluble interleukin-15 receptor subunit alpha; High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG- [...]
ARPC4-TTLL3 protein networkhttps://string-db.org/network/9606.ENSP00000380427ARPC4-TTLL3 readthrough.
INS protein networkhttps://string-db.org/network/9606.ENSP00000380432Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cy [...]
SLC22A17 protein networkhttps://string-db.org/network/9606.ENSP00000380437Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internali [...]
INS-IGF2 protein networkhttps://string-db.org/network/9606.ENSP00000380440Insulin, isoform 2; INS-IGF2 readthrough.
PLA2G4F protein networkhttps://string-db.org/network/9606.ENSP00000380442Cytosolic phospholipase A2 zeta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine [...]
NOXO1 protein networkhttps://string-db.org/network/9606.ENSP00000380450NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures [...]
ERMN protein networkhttps://string-db.org/network/9606.ENSP00000380453Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May p [...]
PLAA protein networkhttps://string-db.org/network/9606.ENSP00000380460Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins traffickin [...]
MRPL23 protein networkhttps://string-db.org/network/9606.ENSP00000380466Mitochondrial ribosomal protein L23.
JMJD7 protein networkhttps://string-db.org/network/9606.ENSP00000380467Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7; Bifunctional enzyme that acts both as an endopeptidase and 2- oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-t [...]
MYCL protein networkhttps://string-db.org/network/9606.ENSP00000380494Protein L-Myc; MYCL proto-oncogene, bHLH transcription factor.
DDX51 protein networkhttps://string-db.org/network/9606.ENSP00000380495ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.
HAGH protein networkhttps://string-db.org/network/9606.ENSP00000380514Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.
CDH24 protein networkhttps://string-db.org/network/9606.ENSP00000380517Cadherin-24; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
CAPSL protein networkhttps://string-db.org/network/9606.ENSP00000380524Calcyphosin-like protein; Calcyphosine like.
DUSP8 protein networkhttps://string-db.org/network/9606.ENSP00000380530Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing [...]
TSPAN4 protein networkhttps://string-db.org/network/9606.ENSP00000380553Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family.
AKAP8L protein networkhttps://string-db.org/network/9606.ENSP00000380557A-kinase anchor protein 8-like; Could play a role in constitutive transport element (CTE)- mediated gene expression by association with DHX9. Increases CTE- dependent nuclear unspliced mRNA expor [...]
CRAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000380559Protein cramped-like; Cramped chromatin regulator homolog 1.
BPIFC protein networkhttps://string-db.org/network/9606.ENSP00000380594BPI fold containing family C.
BLOC1S5 protein networkhttps://string-db.org/network/9606.ENSP00000380598Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
CNTN4 protein networkhttps://string-db.org/network/9606.ENSP00000380602Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
LYPD1 protein networkhttps://string-db.org/network/9606.ENSP00000380605Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity fo [...]
ARL16 protein networkhttps://string-db.org/network/9606.ENSP00000380635ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16.
PTK2B protein networkhttps://string-db.org/network/9606.ENSP00000380638Protein-tyrosine kinase 2-beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remod [...]
TMEM80 protein networkhttps://string-db.org/network/9606.ENSP00000380646Transmembrane protein 80.
EIF4ENIF1 protein networkhttps://string-db.org/network/9606.ENSP00000380659Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism.
CEP250 protein networkhttps://string-db.org/network/9606.ENSP00000380661Centrosome-associated protein CEP250; May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase.
SLC7A7 protein networkhttps://string-db.org/network/9606.ENSP00000380666Y+L amino acid transporter 1; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to [...]
SMCO1 protein networkhttps://string-db.org/network/9606.ENSP00000380671Single-pass membrane protein with coiled-coil domains 1.
WEE2 protein networkhttps://string-db.org/network/9606.ENSP00000380675Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Requ [...]
CDHR5 protein networkhttps://string-db.org/network/9606.ENSP00000380676Cadherin-related family member 5; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, [...]
CCDC40 protein networkhttps://string-db.org/network/9606.ENSP00000380679Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby [...]
BICDL1 protein networkhttps://string-db.org/network/9606.ENSP00000380690BICD family-like cargo adapter 1; Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by contro [...]
KDM7A protein networkhttps://string-db.org/network/9606.ENSP00000380692Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 [...]
IRF7 protein networkhttps://string-db.org/network/9606.ENSP00000380697Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses and plays a critical role in the innate immune response against DNA and RNA vi [...]
MYCBP protein networkhttps://string-db.org/network/9606.ENSP00000380702c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
RASSF7 protein networkhttps://string-db.org/network/9606.ENSP00000380713Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Follo [...]
CDYL protein networkhttps://string-db.org/network/9606.ENSP00000380718Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, [...]
FAM98B protein networkhttps://string-db.org/network/9606.ENSP00000380734Protein FAM98B; Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation. Promotes colorectal cancer cell malignancy. Belongs to the FAM98 family.
FBXL16 protein networkhttps://string-db.org/network/9606.ENSP00000380746F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
TMEM209 protein networkhttps://string-db.org/network/9606.ENSP00000380747Transmembrane protein 209.
PRMT2 protein networkhttps://string-db.org/network/9606.ENSP00000380759Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (w [...]
TEN1 protein networkhttps://string-db.org/network/9606.ENSP00000380762CST complex subunit TEN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...]
MORC2 protein networkhttps://string-db.org/network/9606.ENSP00000380763ATPase MORC2; Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are criti [...]
TCTN1 protein networkhttps://string-db.org/network/9606.ENSP00000380779Tectonic-1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between t [...]
NFIX protein networkhttps://string-db.org/network/9606.ENSP00000380781Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...]
HOOK2 protein networkhttps://string-db.org/network/9606.ENSP00000380785Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting [...]
ALG3 protein networkhttps://string-db.org/network/9606.ENSP00000380793Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.
CHMP7 protein networkhttps://string-db.org/network/9606.ENSP00000380794Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex pr [...]
LSS protein networkhttps://string-db.org/network/9606.ENSP00000380837Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein agg [...]
ZNF709 protein networkhttps://string-db.org/network/9606.ENSP00000380840Zinc finger protein 709; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PDCD1LG2 protein networkhttps://string-db.org/network/9606.ENSP00000380855Programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cel [...]
FTCD protein networkhttps://string-db.org/network/9606.ENSP00000380856Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folat [...]
RAB2B protein networkhttps://string-db.org/network/9606.ENSP00000380869Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex.
PGBD4 protein networkhttps://string-db.org/network/9606.ENSP00000380872piggyBac transposable element derived 4.
RGS11 protein networkhttps://string-db.org/network/9606.ENSP00000380876Regulator of G-protein signaling 11; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
ASCC2 protein networkhttps://string-db.org/network/9606.ENSP00000380877Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquiti [...]
PPP3CC protein networkhttps://string-db.org/network/9606.ENSP00000380878Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracel [...]
SLC66A2 protein networkhttps://string-db.org/network/9606.ENSP00000380880Solute carrier family 66 member 2.
MED13 protein networkhttps://string-db.org/network/9606.ENSP00000380888Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
COL8A2 protein networkhttps://string-db.org/network/9606.ENSP00000380901Collagen alpha-2(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the en [...]
ROBO3 protein networkhttps://string-db.org/network/9606.ENSP00000380903Roundabout homolog 3; Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube (By similarity). In spinal chord development plays a role in [...]
POLR3D protein networkhttps://string-db.org/network/9606.ENSP00000380904DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
CEP83 protein networkhttps://string-db.org/network/9606.ENSP00000380911Centrosomal protein of 83 kDa; Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ci [...]
C19orf38 protein networkhttps://string-db.org/network/9606.ENSP00000380920Protein HIDE1; Chromosome 19 open reading frame 38.
SH3KBP1 protein networkhttps://string-db.org/network/9606.ENSP00000380921SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of [...]
ARHGEF12 protein networkhttps://string-db.org/network/9606.ENSP00000380942Rho guanine nucleotide exchange factor 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchang [...]
ITGB2 protein networkhttps://string-db.org/network/9606.ENSP00000380948Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interacti [...]
MBP protein networkhttps://string-db.org/network/9606.ENSP00000380958Myelin basic protein; The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its fo [...]
C17orf67 protein networkhttps://string-db.org/network/9606.ENSP00000380959Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67.
PUM3 protein networkhttps://string-db.org/network/9606.ENSP00000380982Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence spe [...]
KIAA1211L protein networkhttps://string-db.org/network/9606.ENSP00000380996Uncharacterized protein KIAA1211-like.
CHMP1A protein networkhttps://string-db.org/network/9606.ENSP00000380998Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodi [...]
ZNF846 protein networkhttps://string-db.org/network/9606.ENSP00000380999Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TTC28 protein networkhttps://string-db.org/network/9606.ENSP00000381003Tetratricopeptide repeat protein 28; During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
KRTAP12-3 protein networkhttps://string-db.org/network/9606.ENSP00000381005Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
NAV3 protein networkhttps://string-db.org/network/9606.ENSP00000381007Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family.
MUC16 protein networkhttps://string-db.org/network/9606.ENSP00000381008Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
KRTAP10-9 protein networkhttps://string-db.org/network/9606.ENSP00000381009Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
TRPM2 protein networkhttps://string-db.org/network/9606.ENSP00000381026Transient receptor potential cation channel subfamily M member 2; [Isoform 1]: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytopla [...]
NPM2 protein networkhttps://string-db.org/network/9606.ENSP00000381032Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during [...]
SOCS6 protein networkhttps://string-db.org/network/9606.ENSP00000381034Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of [...]
ADGB protein networkhttps://string-db.org/network/9606.ENSP00000381036Androglobin.
CFAP410 protein networkhttps://string-db.org/network/9606.ENSP00000381047Cilia and flagella associated protein 410.
RNASE1 protein networkhttps://string-db.org/network/9606.ENSP00000381057Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA; Belongs to the pancreatic ribo [...]
CDH7 protein networkhttps://string-db.org/network/9606.ENSP00000381058Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
INTS10 protein networkhttps://string-db.org/network/9606.ENSP00000381064Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Th [...]
MAP2K7 protein networkhttps://string-db.org/network/9606.ENSP00000381070Dual specificity mitogen-activated protein kinase kinase 7; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component [...]
DIPK2B protein networkhttps://string-db.org/network/9606.ENSP00000381086Divergent protein kinase domain 2B.
SLC35E3 protein networkhttps://string-db.org/network/9606.ENSP00000381089Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily.
EPHB1 protein networkhttps://string-db.org/network/9606.ENSP00000381097Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
GRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000381098Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners a [...]
SERPINB7 protein networkhttps://string-db.org/network/9606.ENSP00000381101Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.
PIP4P1 protein networkhttps://string-db.org/network/9606.ENSP00000381102Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). Do [...]
TM9SF4 protein networkhttps://string-db.org/network/9606.ENSP00000381104Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly an [...]
NPS protein networkhttps://string-db.org/network/9606.ENSP00000381105Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium conce [...]
ZCWPW1 protein networkhttps://string-db.org/network/9606.ENSP00000381109Zinc finger CW-type and PWWP domain containing 1.
GRK4 protein networkhttps://string-db.org/network/9606.ENSP00000381129G protein-coupled receptor kinase 4; Specifically phosphorylates the activated forms of G protein- coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmo [...]
FGL1 protein networkhttps://string-db.org/network/9606.ENSP00000381133Fibrinogen-like protein 1; Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Bind [...]
CTDSP2 protein networkhttps://string-db.org/network/9606.ENSP00000381148Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain [...]
MBLAC1 protein networkhttps://string-db.org/network/9606.ENSP00000381150Metallo-beta-lactamase domain containing 1.
BCL2 protein networkhttps://string-db.org/network/9606.ENSP00000381185Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial [...]
TMEM123 protein networkhttps://string-db.org/network/9606.ENSP00000381204Porimin; Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.
RDH16 protein networkhttps://string-db.org/network/9606.ENSP00000381206Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activi [...]
HPS4 protein networkhttps://string-db.org/network/9606.ENSP00000381213Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting t [...]
RGPD2 protein networkhttps://string-db.org/network/9606.ENSP00000381214RANBP2 like and GRIP domain containing 2.
KHSRP protein networkhttps://string-db.org/network/9606.ENSP00000381216Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream co [...]
HDDC2 protein networkhttps://string-db.org/network/9606.ENSP00000381220HD domain containing 2.
CBS protein networkhttps://string-db.org/network/9606.ENSP00000381231Cystathionine beta-synthase-like protein; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-rep [...]
HM13 protein networkhttps://string-db.org/network/9606.ENSP00000381237Minor histocompatibility antigen H13; Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the [...]
EFCAB9 protein networkhttps://string-db.org/network/9606.ENSP00000381247EF-hand calcium-binding domain-containing protein 9; pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivat [...]
APOF protein networkhttps://string-db.org/network/9606.ENSP00000381250Apolipoprotein F; Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Als [...]
WDR4 protein networkhttps://string-db.org/network/9606.ENSP00000381266tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA speci [...]
TBC1D32 protein networkhttps://string-db.org/network/9606.ENSP00000381270Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliar [...]
CD200R1L protein networkhttps://string-db.org/network/9606.ENSP00000381272Cell surface glycoprotein CD200 receptor 2; May be a receptor for the CD200/OX2 cell surface glycoprotein.
SELENOS protein networkhttps://string-db.org/network/9606.ENSP00000381282Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where [...]
NSF protein networkhttps://string-db.org/network/9606.ENSP00000381293Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulu [...]
LONRF1 protein networkhttps://string-db.org/network/9606.ENSP00000381298LON peptidase N-terminal domain and ring finger 1.
PLPP4 protein networkhttps://string-db.org/network/9606.ENSP00000381302Phospholipid phosphatase 4; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphati [...]
CRHR1 protein networkhttps://string-db.org/network/9606.ENSP00000381333Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conf [...]
GNAT3 protein networkhttps://string-db.org/network/9606.ENSP00000381339Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in [...]
GGT5 protein networkhttps://string-db.org/network/9606.ENSP00000381340Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).
CABIN1 protein networkhttps://string-db.org/network/9606.ENSP00000381364Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcine [...]
ARPIN-AP3S2 protein networkhttps://string-db.org/network/9606.ENSP00000381377Protein C15orf38-AP3S2; ARPIN-AP3S2 readthrough.
TCF4 protein networkhttps://string-db.org/network/9606.ENSP00000381382Transcription factor 4; Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding [...]
DDT protein networkhttps://string-db.org/network/9606.ENSP00000381386D-dopachrome decarboxylase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
CGGBP1 protein networkhttps://string-db.org/network/9606.ENSP00000381429CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter.
MPP3 protein networkhttps://string-db.org/network/9606.ENSP00000381430MAGUK p55 subfamily member 3; Membrane palmitoylated protein 3; Belongs to the MAGUK family.
VGLL3 protein networkhttps://string-db.org/network/9606.ENSP00000381436Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs.
CST3 protein networkhttps://string-db.org/network/9606.ENSP00000381448Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family.
PPME1 protein networkhttps://string-db.org/network/9606.ENSP00000381461Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion a [...]
HIGD1C protein networkhttps://string-db.org/network/9606.ENSP00000381473HIG1 hypoxia inducible domain family member 1C.
TMPRSS12 protein networkhttps://string-db.org/network/9606.ENSP00000381476Transmembrane serine protease 12; Belongs to the peptidase S1 family.
SPAG11B protein networkhttps://string-db.org/network/9606.ENSP00000381480Sperm associated antigen 11B.
NOTO protein networkhttps://string-db.org/network/9606.ENSP00000381486Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formati [...]
KRTAP9-1 protein networkhttps://string-db.org/network/9606.ENSP00000381488Keratin-associated protein 9-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP4-1 protein networkhttps://string-db.org/network/9606.ENSP00000381489Keratin-associated protein 4-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
LAT2 protein networkhttps://string-db.org/network/9606.ENSP00000381492Linker for activation of T-cells family member 2; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen r [...]
KRTAP2-2 protein networkhttps://string-db.org/network/9606.ENSP00000381494Keratin-associated protein 2-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
FGFRL1 protein networkhttps://string-db.org/network/9606.ENSP00000381498Fibroblast growth factor receptor-like 1; Has a negative effect on cell proliferation.
PAX1 protein networkhttps://string-db.org/network/9606.ENSP00000381499Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal developm [...]
PRPS2 protein networkhttps://string-db.org/network/9606.ENSP00000381504Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase f [...]
CSNK1D protein networkhttps://string-db.org/network/9606.ENSP00000381531Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. I [...]
STK32A protein networkhttps://string-db.org/network/9606.ENSP00000381535Serine/threonine kinase 32A.
KRTAP5-11 protein networkhttps://string-db.org/network/9606.ENSP00000381541Keratin-associated protein 5-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which [...]
KRTAP5-10 protein networkhttps://string-db.org/network/9606.ENSP00000381542Keratin-associated protein 5-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which [...]
FRMD4B protein networkhttps://string-db.org/network/9606.ENSP00000381549FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffoldin [...]
CFAP53 protein networkhttps://string-db.org/network/9606.ENSP00000381553Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.
USP34 protein networkhttps://string-db.org/network/9606.ENSP00000381577Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activat [...]
LCP1 protein networkhttps://string-db.org/network/9606.ENSP00000381581Plastin-2; Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and C [...]
TMPRSS2 protein networkhttps://string-db.org/network/9606.ENSP00000381588Transmembrane protease serine 2 non-catalytic chain; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike p [...]
PCDHGA11 protein networkhttps://string-db.org/network/9606.ENSP00000381589Protocadherin gamma-A11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PCDHGB7 protein networkhttps://string-db.org/network/9606.ENSP00000381594Protocadherin gamma-B7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
MX1 protein networkhttps://string-db.org/network/9606.ENSP00000381601Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its ta [...]
PCDHGA8 protein networkhttps://string-db.org/network/9606.ENSP00000381605Protocadherin gamma-A8; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
GSTP1 protein networkhttps://string-db.org/network/9606.ENSP00000381607Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocatio [...]
PCDHGA10 protein networkhttps://string-db.org/network/9606.ENSP00000381611Protocadherin gamma-A10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
ZNF596 protein networkhttps://string-db.org/network/9606.ENSP00000381613Zinc finger protein 596; May be involved in transcriptional regulation.
PCDHA12 protein networkhttps://string-db.org/network/9606.ENSP00000381628Protocadherin alpha-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
C2orf73 protein networkhttps://string-db.org/network/9606.ENSP00000381631Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73.
PCDHA11 protein networkhttps://string-db.org/network/9606.ENSP00000381636Protocadherin alpha-11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
EIPR1 protein networkhttps://string-db.org/network/9606.ENSP00000381652EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the t [...]
HMGCLL1 protein networkhttps://string-db.org/network/9606.ENSP000003816543-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA i [...]
DOT1L protein networkhttps://string-db.org/network/9606.ENSP00000381657Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to [...]
GXYLT1 protein networkhttps://string-db.org/network/9606.ENSP00000381666Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of x [...]
TP53TG3 protein networkhttps://string-db.org/network/9606.ENSP00000381672TP53 target 3.
ZSWIM8 protein networkhttps://string-db.org/network/9606.ENSP00000381693Zinc finger SWIM-type containing 8.
SHARPIN protein networkhttps://string-db.org/network/9606.ENSP00000381698Sharpin; Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflamm [...]
B3GALT5 protein networkhttps://string-db.org/network/9606.ENSP00000381699Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Ce [...]
DEFB113 protein networkhttps://string-db.org/network/9606.ENSP00000381703Beta-defensin 113; Has antibacterial activity; Belongs to the beta-defensin family.
UBE2D2 protein networkhttps://string-db.org/network/9606.ENSP00000381717Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates [...]
ATP5F1A protein networkhttps://string-db.org/network/9606.ENSP00000381736ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...]
PARP3 protein networkhttps://string-db.org/network/9606.ENSP00000381740Protein mono-ADP-ribosyltransferase PARP3; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-AD [...]
CAPN11 protein networkhttps://string-db.org/network/9606.ENSP00000381758Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase [...]
IQCF6 protein networkhttps://string-db.org/network/9606.ENSP00000381760IQ motif containing F6.
TOP3B protein networkhttps://string-db.org/network/9606.ENSP00000381773DNA topoisomerase 3-beta-1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the [...]
TNFSF11 protein networkhttps://string-db.org/network/9606.ENSP00000381775Tumor necrosis factor ligand superfamily member 11, membrane form; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the abili [...]
SLC25A45 protein networkhttps://string-db.org/network/9606.ENSP00000381782Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family.
HSDL2 protein networkhttps://string-db.org/network/9606.ENSP00000381785Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
CCDC33 protein networkhttps://string-db.org/network/9606.ENSP00000381795Coiled-coil domain containing 33.
YPEL3 protein networkhttps://string-db.org/network/9606.ENSP00000381821Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells.
SEC24A protein networkhttps://string-db.org/network/9606.ENSP00000381823Protein transport protein Sec24A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
AEBP2 protein networkhttps://string-db.org/network/9606.ENSP00000381840Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3.
ATL3 protein networkhttps://string-db.org/network/9606.ENSP00000381844Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...]
MROH6 protein networkhttps://string-db.org/network/9606.ENSP00000381857Maestro heat like repeat family member 6.
TOMM6 protein networkhttps://string-db.org/network/9606.ENSP00000381859Mitochondrial import receptor subunit TOM6 homolog; Translocase of outer mitochondrial membrane 6.
DAAM2 protein networkhttps://string-db.org/network/9606.ENSP00000381876Disheveled-associated activator of morphogenesis 2; Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determinatio [...]
SMCO3 protein networkhttps://string-db.org/network/9606.ENSP00000381895Single-pass membrane protein with coiled-coil domains 3.
KCNJ15 protein networkhttps://string-db.org/network/9606.ENSP00000381911ATP-sensitive inward rectifier potassium channel 15; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Th [...]
MGARP protein networkhttps://string-db.org/network/9606.ENSP00000381928Protein MGARP; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hyp [...]
COL13A1 protein networkhttps://string-db.org/network/9606.ENSP00000381949Collagen alpha-1(XIII) chain; Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basemen [...]
KSR1 protein networkhttps://string-db.org/network/9606.ENSP00000381958Kinase suppressor of Ras 1; Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently o [...]
SPTLC3 protein networkhttps://string-db.org/network/9606.ENSP00000381968Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) [...]
GIN1 protein networkhttps://string-db.org/network/9606.ENSP00000381970Gypsy retrotransposon integrase 1.
TTC3 protein networkhttps://string-db.org/network/9606.ENSP00000381981E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphoryla [...]
RPRD1A protein networkhttps://string-db.org/network/9606.ENSP00000381984Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and partici [...]
CDRT15L2 protein networkhttps://string-db.org/network/9606.ENSP00000382000CMT1A duplicated region transcript 15 like 2.
CTNND1 protein networkhttps://string-db.org/network/9606.ENSP00000382004Catenin delta-1; Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Be [...]
ZNF24 protein networkhttps://string-db.org/network/9606.ENSP00000382015Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinatin [...]
LCMT1 protein networkhttps://string-db.org/network/9606.ENSP00000382021Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues.
C4orf3 protein networkhttps://string-db.org/network/9606.ENSP00000382026Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3.
RAD51AP2 protein networkhttps://string-db.org/network/9606.ENSP00000382030RAD51 associated protein 2.
HLCS protein networkhttps://string-db.org/network/9606.ENSP00000382071Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxyla [...]
COL25A1 protein networkhttps://string-db.org/network/9606.ENSP00000382083Collagen-like Alzheimer amyloid plaque component; Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resist [...]
EVPLL protein networkhttps://string-db.org/network/9606.ENSP00000382086Envoplakin-like protein; Envoplakin like; Belongs to the plakin or cytolinker family.
CLDN14 protein networkhttps://string-db.org/network/9606.ENSP00000382090Claudin-14; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
ALKBH5 protein networkhttps://string-db.org/network/9606.ENSP00000382091RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messeng [...]
DCDC2C protein networkhttps://string-db.org/network/9606.ENSP00000382097Doublecortin domain containing 2C.
DOP1B protein networkhttps://string-db.org/network/9606.ENSP00000382104Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes.
AIFM3 protein networkhttps://string-db.org/network/9606.ENSP00000382120Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
DRC3 protein networkhttps://string-db.org/network/9606.ENSP00000382140Dynein regulatory complex subunit 3; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the dist [...]
SETD4 protein networkhttps://string-db.org/network/9606.ENSP00000382163SET domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family.
MYO5A protein networkhttps://string-db.org/network/9606.ENSP00000382177Unconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates th [...]
JMJD1C protein networkhttps://string-db.org/network/9606.ENSP00000382204Probable JmjC domain-containing histone demethylation protein 2C; Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code [...]
ZSWIM7 protein networkhttps://string-db.org/network/9606.ENSP00000382218Zinc finger SWIM domain-containing protein 7; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced [...]
KCNE1 protein networkhttps://string-db.org/network/9606.ENSP00000382226Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...]
TMEM26 protein networkhttps://string-db.org/network/9606.ENSP00000382237Transmembrane protein 26.
RBM12B protein networkhttps://string-db.org/network/9606.ENSP00000382239RNA binding motif protein 12B.
QSER1 protein networkhttps://string-db.org/network/9606.ENSP00000382241Glutamine and serine rich 1.
MRPS6 protein networkhttps://string-db.org/network/9606.ENSP00000382250Mitochondrial ribosomal protein S6.
HECTD1 protein networkhttps://string-db.org/network/9606.ENSP00000382269E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...]
NOMO3 protein networkhttps://string-db.org/network/9606.ENSP00000382274Nodal modulator 3; May antagonize Nodal signaling.
OTOG protein networkhttps://string-db.org/network/9606.ENSP00000382323Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule [...]
SDR39U1 protein networkhttps://string-db.org/network/9606.ENSP00000382327Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
N4BP2L2 protein networkhttps://string-db.org/network/9606.ENSP00000382328NEDD4 binding protein 2 like 2.
RNF222 protein networkhttps://string-db.org/network/9606.ENSP00000382330Ring finger protein 222.
PSG5 protein networkhttps://string-db.org/network/9606.ENSP00000382334Pregnancy specific beta-1-glycoprotein 5; Belongs to the immunoglobulin superfamily. CEA family.
RABGGTA protein networkhttps://string-db.org/network/9606.ENSP00000382341Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence - [...]
ABCC1 protein networkhttps://string-db.org/network/9606.ENSP00000382342Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene [...]
ACSM4 protein networkhttps://string-db.org/network/9606.ENSP00000382349Acyl-coenzyme A synthetase ACSM4, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activat [...]
COL28A1 protein networkhttps://string-db.org/network/9606.ENSP00000382356Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family.
ANKRD28 protein networkhttps://string-db.org/network/9606.ENSP00000382379Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...]
USP47 protein networkhttps://string-db.org/network/9606.ENSP00000382382Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in ba [...]
NEURL4 protein networkhttps://string-db.org/network/9606.ENSP00000382390Neuralized-like protein 4; Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing form [...]
MAP3K1 protein networkhttps://string-db.org/network/9606.ENSP00000382423Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May [...]
PLA2G4E protein networkhttps://string-db.org/network/9606.ENSP00000382434Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.
C22orf39 protein networkhttps://string-db.org/network/9606.ENSP00000382474UPF0545 protein C22orf39; Chromosome 22 open reading frame 39; Belongs to the UPF0545 family.
MROH2B protein networkhttps://string-db.org/network/9606.ENSP00000382476Maestro heat-like repeat-containing protein family member 2B; May play a role in the process of sperm capacitation.
OPRPN protein networkhttps://string-db.org/network/9606.ENSP00000382485Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC( [...]
RADIL protein networkhttps://string-db.org/network/9606.ENSP00000382492Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. Belongs to the RADIL famil [...]
UBXN2B protein networkhttps://string-db.org/network/9606.ENSP00000382507UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their r [...]
CDIP1 protein networkhttps://string-db.org/network/9606.ENSP00000382508Cell death-inducing p53-target protein 1; Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. Belongs to the CDIP1/LITAF famil [...]
ZNF195 protein networkhttps://string-db.org/network/9606.ENSP00000382511Zinc finger protein 195; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SRL protein networkhttps://string-db.org/network/9606.ENSP00000382518Sarcalumenin; May be involved in the regulation of calcium transport.
TSSK2 protein networkhttps://string-db.org/network/9606.ENSP00000382544Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in [...]
KRTAP5-5 protein networkhttps://string-db.org/network/9606.ENSP00000382584Keratin-associated protein 5-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
KRTAP5-4 protein networkhttps://string-db.org/network/9606.ENSP00000382590Keratin associated protein 5-4.
KRTAP5-3 protein networkhttps://string-db.org/network/9606.ENSP00000382592Keratin associated protein 5-3.
PAICS protein networkhttps://string-db.org/network/9606.ENSP00000382595Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
ANKRD18A protein networkhttps://string-db.org/network/9606.ENSP00000382610Ankyrin repeat domain 18A.
RBBP8 protein networkhttps://string-db.org/network/9606.ENSP00000382628DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombi [...]
FAM166B protein networkhttps://string-db.org/network/9606.ENSP00000382646Protein FAM166B; Family with sequence similarity 166 member B; Belongs to the UPF0605 family.
GRXCR1 protein networkhttps://string-db.org/network/9606.ENSP00000382670Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Belongs to the GRXCR1 family.
ENHO protein networkhttps://string-db.org/network/9606.ENSP00000382675Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism.
MRAP protein networkhttps://string-db.org/network/9606.ENSP00000382684Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing gen [...]
KDM5A protein networkhttps://string-db.org/network/9606.ENSP00000382688Lysine-specific demethylase 5A; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', [...]
ROCK1 protein networkhttps://string-db.org/network/9606.ENSP00000382697Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organizat [...]
IFITM3 protein networkhttps://string-db.org/network/9606.ENSP00000382707Interferon-induced transmembrane protein 3; IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by prevent [...]
C5orf49 protein networkhttps://string-db.org/network/9606.ENSP00000382708Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49.
UBE2QL1 protein networkhttps://string-db.org/network/9606.ENSP00000382713Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination [...]
WDR19 protein networkhttps://string-db.org/network/9606.ENSP00000382717WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is [...]
ADA2 protein networkhttps://string-db.org/network/9606.ENSP00000382731Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated [...]
SEL1L3 protein networkhttps://string-db.org/network/9606.ENSP00000382767Protein sel-1 homolog 3; SEL1L family member 3.
KCNU1 protein networkhttps://string-db.org/network/9606.ENSP00000382770Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatoz [...]
KRTAP13-2 protein networkhttps://string-db.org/network/9606.ENSP00000382777Keratin-associated protein 13-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
SEH1L protein networkhttps://string-db.org/network/9606.ENSP00000382779Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex i [...]
CLDN8 protein networkhttps://string-db.org/network/9606.ENSP00000382783Claudin-8; Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight ju [...]
RNF212B protein networkhttps://string-db.org/network/9606.ENSP00000382794Ring finger protein 212B.
RUNX3 protein networkhttps://string-db.org/network/9606.ENSP00000382800Runt-related transcription factor 3; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the cor [...]
ODF3B protein networkhttps://string-db.org/network/9606.ENSP00000382804Outer dense fiber of sperm tails 3B.
BACH1 protein networkhttps://string-db.org/network/9606.ENSP00000382805Transcription regulator protein BACH1; Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordina [...]
FAM234A protein networkhttps://string-db.org/network/9606.ENSP00000382814Protein FAM234A; Family with sequence similarity 234 member A; Belongs to the FAM234 family.
KIAA2026 protein networkhttps://string-db.org/network/9606.ENSP00000382815Uncharacterized protein KIAA2026; KIAA2026.
MAP3K7CL protein networkhttps://string-db.org/network/9606.ENSP00000382828MAP3K7 C-terminal-like protein; MAP3K7 C-terminal like.
MTRNR2L4 protein networkhttps://string-db.org/network/9606.ENSP00000382856Humanin-like 4; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
MAGEB16 protein networkhttps://string-db.org/network/9606.ENSP00000382871Melanoma-associated antigen B16; MAGE family member B16.
MAGEB17 protein networkhttps://string-db.org/network/9606.ENSP00000382884Melanoma-associated antigen B17; MAGE family member B17.
RPGRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000382895X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Re [...]
DEFB130A protein networkhttps://string-db.org/network/9606.ENSP00000382951Beta-defensin 130A; Antimicrobial host-defense peptide. Has an antiplasmodial activity.
GABRA5 protein networkhttps://string-db.org/network/9606.ENSP00000382953Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
ZNF705D protein networkhttps://string-db.org/network/9606.ENSP00000382957Zinc finger protein 705D; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
L3MBTL4 protein networkhttps://string-db.org/network/9606.ENSP00000382976Lethal(3)malignant brain tumor-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...]
TUBA3C protein networkhttps://string-db.org/network/9606.ENSP00000382982Tubulin alpha 3c.
ZNF705B protein networkhttps://string-db.org/network/9606.ENSP00000382987Putative zinc finger protein 705B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
FKBP1A protein networkhttps://string-db.org/network/9606.ENSP00000383003Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of l [...]
ZNF705G protein networkhttps://string-db.org/network/9606.ENSP00000383020Putative zinc finger protein 705G; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MYL5 protein networkhttps://string-db.org/network/9606.ENSP00000383023Myosin light chain 5.
KDM1A protein networkhttps://string-db.org/network/9606.ENSP00000383042Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depend [...]
USP25 protein networkhttps://string-db.org/network/9606.ENSP00000383044Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycl [...]
EPHB2 protein networkhttps://string-db.org/network/9606.ENSP00000383053Ephrin type-B receptor 2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
ARGLU1 protein networkhttps://string-db.org/network/9606.ENSP00000383059Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1.
TPTEP2-CSNK1E protein networkhttps://string-db.org/network/9606.ENSP00000383067TPTEP2-CSNK1E readthrough.
TPTE2 protein networkhttps://string-db.org/network/9606.ENSP00000383089Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphos [...]
RFPL2 protein networkhttps://string-db.org/network/9606.ENSP00000383096Ret finger protein like 2.
COLEC12 protein networkhttps://string-db.org/network/9606.ENSP00000383115Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the r [...]
SFI1 protein networkhttps://string-db.org/network/9606.ENSP00000383145Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. Belongs to the SFI1 family.
PCBP3 protein networkhttps://string-db.org/network/9606.ENSP00000383168Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
DIAPH3 protein networkhttps://string-db.org/network/9606.ENSP00000383178Protein diaphanous homolog 3; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fibe [...]
MACC1 protein networkhttps://string-db.org/network/9606.ENSP00000383185Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth [...]
NEDD4L protein networkhttps://string-db.org/network/9606.ENSP00000383199E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiq [...]
SGSM1 protein networkhttps://string-db.org/network/9606.ENSP00000383212Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and R [...]
KRTAP10-12 protein networkhttps://string-db.org/network/9606.ENSP00000383216Keratin-associated protein 10-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), whic [...]
KRTAP10-6 protein networkhttps://string-db.org/network/9606.ENSP00000383219Keratin-associated protein 10-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP10-5 protein networkhttps://string-db.org/network/9606.ENSP00000383223Keratin-associated protein 10-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP10-4 protein networkhttps://string-db.org/network/9606.ENSP00000383225Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
KRTAP10-1 protein networkhttps://string-db.org/network/9606.ENSP00000383226Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
GGT1-2 protein networkhttps://string-db.org/network/9606.ENSP00000383232Gamma-glutamyltransferase 1.
MAPK4 protein networkhttps://string-db.org/network/9606.ENSP00000383234Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still uncle [...]
SIAH3 protein networkhttps://string-db.org/network/9606.ENSP00000383256Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depol [...]
SMIM2 protein networkhttps://string-db.org/network/9606.ENSP00000383270Small integral membrane protein 2.
EIF4G3 protein networkhttps://string-db.org/network/9606.ENSP00000383274Eukaryotic translation initiation factor 4 gamma 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal s [...]
NBEA protein networkhttps://string-db.org/network/9606.ENSP00000383295Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By sim [...]
ZNF74 protein networkhttps://string-db.org/network/9606.ENSP00000383301Zinc finger protein 74; May play a role in RNA metabolism; Belongs to the krueppel C2H2-type zinc-finger protein family.
DSCAM protein networkhttps://string-db.org/network/9606.ENSP00000383303Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the s [...]
MORC3 protein networkhttps://string-db.org/network/9606.ENSP00000383333MORC family CW-type zinc finger protein 3; Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP5 [...]
PLA2G2A protein networkhttps://string-db.org/network/9606.ENSP00000383364Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metaboli [...]
TXNRD2 protein networkhttps://string-db.org/network/9606.ENSP00000383365Thioredoxin reductase 2, mitochondrial; Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. [...]
EFCAB8 protein networkhttps://string-db.org/network/9606.ENSP00000383366EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8.
JAM2 protein networkhttps://string-db.org/network/9606.ENSP00000383376Junctional adhesion molecule B; Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role [...]
GP1BB protein networkhttps://string-db.org/network/9606.ENSP00000383382Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to [...]
NCAM2 protein networkhttps://string-db.org/network/9606.ENSP00000383392Neural cell adhesion molecule 2; May play important roles in selective fasciculation and zone- to-zone projection of the primary olfactory axons.
DEFB116 protein networkhttps://string-db.org/network/9606.ENSP00000383396Beta-defensin 116; Has antibacterial activity; Belongs to the beta-defensin family.
DEFB115 protein networkhttps://string-db.org/network/9606.ENSP00000383398Beta-defensin 115; Has antibacterial activity; Belongs to the beta-defensin family.
PPP4R1 protein networkhttps://string-db.org/network/9606.ENSP00000383402Serine/threonine-protein phosphatase 4 regulatory subunit 1; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The P [...]
RBM11 protein networkhttps://string-db.org/network/9606.ENSP00000383421Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-media [...]
CECR2 protein networkhttps://string-db.org/network/9606.ENSP00000383428Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex. It the [...]
GAB4 protein networkhttps://string-db.org/network/9606.ENSP00000383431GRB2 associated binding protein family member 4; Belongs to the GAB family.
ZDHHC20 protein networkhttps://string-db.org/network/9606.ENSP00000383433Palmitoyltransferase ZDHHC20; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the durati [...]
C9orf152 protein networkhttps://string-db.org/network/9606.ENSP00000383456Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152.
KLHDC7A protein networkhttps://string-db.org/network/9606.ENSP00000383505Kelch domain containing 7A.
HMX1 protein networkhttps://string-db.org/network/9606.ENSP00000383516Homeobox protein HMX1; DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May pla [...]
GCGR protein networkhttps://string-db.org/network/9606.ENSP00000383558Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose produ [...]
ZG16 protein networkhttps://string-db.org/network/9606.ENSP00000383563Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) an [...]
TMEM242 protein networkhttps://string-db.org/network/9606.ENSP00000383594Transmembrane protein 242; Belongs to the TMEM242 family.
WDR47 protein networkhttps://string-db.org/network/9606.ENSP00000383599WD repeat domain 47.
CCNL2 protein networkhttps://string-db.org/network/9606.ENSP00000383611Cyclin-L2; Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors.
FAM72D protein networkhttps://string-db.org/network/9606.ENSP00000383682Protein FAM72D; Family with sequence similarity 72 member D.
MASP2 protein networkhttps://string-db.org/network/9606.ENSP00000383690Mannan-binding lectin serine protease 2 A chain; Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-cataly [...]
CENPS-CORT protein networkhttps://string-db.org/network/9606.ENSP00000383692CENPS-CORT readthrough.
SLC2A7 protein networkhttps://string-db.org/network/9606.ENSP00000383698Solute carrier family 2, facilitated glucose transporter member 7; Probable sugar transporter. Its physiological substrate is subject to discussion. Does not transport galactose, 2-deoxy-d-glucos [...]
FAAP20 protein networkhttps://string-db.org/network/9606.ENSP00000383710FA core complex associated protein 20.
UBE2J2 protein networkhttps://string-db.org/network/9606.ENSP00000383719Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endopl [...]
DNAH14 protein networkhttps://string-db.org/network/9606.ENSP00000383737Dynein axonemal heavy chain 14.
OAZ3 protein networkhttps://string-db.org/network/9606.ENSP00000383784Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...]
MIER1 protein networkhttps://string-db.org/network/9606.ENSP00000383820Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a [...]
MMACHC protein networkhttps://string-db.org/network/9606.ENSP00000383840Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also [...]
KIAA1522 protein networkhttps://string-db.org/network/9606.ENSP00000383851Uncharacterized protein KIAA1522; KIAA1522.
SZRD1 protein networkhttps://string-db.org/network/9606.ENSP00000383866SUZ RNA binding domain containing 1.
MATN3 protein networkhttps://string-db.org/network/9606.ENSP00000383894Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
LIPK protein networkhttps://string-db.org/network/9606.ENSP00000383900Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
LIPM protein networkhttps://string-db.org/network/9606.ENSP00000383901Lipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers. Bel [...]
DMRTA2 protein networkhttps://string-db.org/network/9606.ENSP00000383909Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development.
UBAC2 protein networkhttps://string-db.org/network/9606.ENSP00000383911Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, [...]
ASXL2 protein networkhttps://string-db.org/network/9606.ENSP00000383920Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive s [...]
ZNF610 protein networkhttps://string-db.org/network/9606.ENSP00000383922Zinc finger protein 610; May be involved in transcriptional regulation.
LIPN protein networkhttps://string-db.org/network/9606.ENSP00000383923Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
GP5 protein networkhttps://string-db.org/network/9606.ENSP00000383931Platelet glycoprotein V; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces [...]
TAFA5 protein networkhttps://string-db.org/network/9606.ENSP00000383933Chemokine-like protein TAFA-5; Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (B [...]
CRELD2 protein networkhttps://string-db.org/network/9606.ENSP00000383938Protein disulfide isomerase CRELD2; Protein disulfide isomerase (By similarity). Might play a role in the unfolded protein response (By similarity). May regulate transport of alpha4-beta2 neurona [...]
SNU13 protein networkhttps://string-db.org/network/9606.ENSP00000383949NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. [...]
CDCA7L protein networkhttps://string-db.org/network/9606.ENSP00000383986Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the pr [...]
CERT1 protein networkhttps://string-db.org/network/9606.ENSP00000383996Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicula [...]
ZNF681 protein networkhttps://string-db.org/network/9606.ENSP00000384000Zinc finger protein 681; May be involved in transcriptional regulation.
POU6F2 protein networkhttps://string-db.org/network/9606.ENSP00000384004POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the [...]
SUN1 protein networkhttps://string-db.org/network/9606.ENSP00000384015SUN domain-containing protein 1; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nuc [...]
NCOR2 protein networkhttps://string-db.org/network/9606.ENSP00000384018Nuclear receptor corepressor 2; Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access [...]
CCDC85A protein networkhttps://string-db.org/network/9606.ENSP00000384040Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family.
PAXIP1 protein networkhttps://string-db.org/network/9606.ENSP00000384048PAX-interacting protein 1; Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage re [...]
CSF2RB protein networkhttps://string-db.org/network/9606.ENSP00000384053Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
EFR3B protein networkhttps://string-db.org/network/9606.ENSP00000384081Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphat [...]
DTNB protein networkhttps://string-db.org/network/9606.ENSP00000384084Dystrobrevin beta.
POMC protein networkhttps://string-db.org/network/9606.ENSP00000384092Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasin [...]
CUL4B protein networkhttps://string-db.org/network/9606.ENSP00000384109Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The func [...]
MEI1 protein networkhttps://string-db.org/network/9606.ENSP00000384115Meiosis inhibitor protein 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity).
C16orf86 protein networkhttps://string-db.org/network/9606.ENSP00000384117Uncharacterized protein C16orf86; Chromosome 16 open reading frame 86.
LRRC32 protein networkhttps://string-db.org/network/9606.ENSP00000384126Transforming growth factor beta activator LRRC32; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state d [...]
RBM33 protein networkhttps://string-db.org/network/9606.ENSP00000384160RNA binding motif protein 33.
KIF16B protein networkhttps://string-db.org/network/9606.ENSP00000384164Kinesin-like protein KIF16B; Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early [...]
FBLN2 protein networkhttps://string-db.org/network/9606.ENSP00000384169Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.
ZFPM2 protein networkhttps://string-db.org/network/9606.ENSP00000384179Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential dur [...]
SCFD2 protein networkhttps://string-db.org/network/9606.ENSP00000384182Sec1 family domain-containing protein 2; May be involved in protein transport; Belongs to the STXBP/unc-18/SEC1 family.
CASTOR1 protein networkhttps://string-db.org/network/9606.ENSP00000384183Cytosolic arginine sensor for mTORC1 subunit 1; Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer [...]
CADM2 protein networkhttps://string-db.org/network/9606.ENSP00000384193Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organ [...]
PDZRN4 protein networkhttps://string-db.org/network/9606.ENSP00000384197PDZ domain containing ring finger 4.
INO80D protein networkhttps://string-db.org/network/9606.ENSP00000384198INO80 complex subunit D; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
PSME4 protein networkhttps://string-db.org/network/9606.ENSP00000384211Proteasome activator complex subunit 4; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core hi [...]
GAGE12D protein networkhttps://string-db.org/network/9606.ENSP00000384214G antigen 12D.
WWC2 protein networkhttps://string-db.org/network/9606.ENSP00000384222Protein WWC2; WW and C2 domain containing 2.
ECE2-2 protein networkhttps://string-db.org/network/9606.ENSP00000384223EEF1AKMT4-ECE2 readthrough transcript protein; Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid- beta processing (By [...]
ATG4B protein networkhttps://string-db.org/network/9606.ENSP00000384259Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABAR [...]
HPSE protein networkhttps://string-db.org/network/9606.ENSP00000384262Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) d [...]
CNGA1 protein networkhttps://string-db.org/network/9606.ENSP00000384264cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, c [...]
RELA protein networkhttps://string-db.org/network/9606.ENSP00000384273Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a v [...]
WDR60 protein networkhttps://string-db.org/network/9606.ENSP00000384290WD repeat-containing protein 60; May play a role in ciliogenesis.
ACY1 protein networkhttps://string-db.org/network/9606.ENSP00000384296Aminoacylase-1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate); Belongs to the peptidase M20A family.
WDR43 protein networkhttps://string-db.org/network/9606.ENSP00000384302WD repeat-containing protein 43; Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for opt [...]
MYH8 protein networkhttps://string-db.org/network/9606.ENSP00000384330Myosin-8; Muscle contraction.
CEBPZOS protein networkhttps://string-db.org/network/9606.ENSP00000384331Protein CEBPZOS; CEBPZ opposite strand.
MEIG1 protein networkhttps://string-db.org/network/9606.ENSP00000384334Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis.
TMEM18 protein networkhttps://string-db.org/network/9606.ENSP00000384347Transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-s [...]
APOBEC3A protein networkhttps://string-db.org/network/9606.ENSP00000384359DNA dC->dU-editing enzyme APOBEC-3A; DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity agains [...]
GDPD3 protein networkhttps://string-db.org/network/9606.ENSP00000384363Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (l [...]
NPY protein networkhttps://string-db.org/network/9606.ENSP00000384364C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family.
KCTD1 protein networkhttps://string-db.org/network/9606.ENSP00000384367BTB/POZ domain-containing protein KCTD1; May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.
METTL15 protein networkhttps://string-db.org/network/9606.ENSP00000384369Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase.
STEAP1B protein networkhttps://string-db.org/network/9606.ENSP00000384370STEAP family member 1B.
BCL6 protein networkhttps://string-db.org/network/9606.ENSP00000384371B-cell lymphoma 6 protein; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the l [...]
TDRD15 protein networkhttps://string-db.org/network/9606.ENSP00000384376Tudor domain containing 15.
HCRTR1 protein networkhttps://string-db.org/network/9606.ENSP00000384387Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response [...]
MEX3D protein networkhttps://string-db.org/network/9606.ENSP00000384398RNA-binding protein MEX3D; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.
CHKB protein networkhttps://string-db.org/network/9606.ENSP00000384400Choline/ethanolamine kinase; Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis.
PARG protein networkhttps://string-db.org/network/9606.ENSP00000384408Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- an [...]
TFIP11 protein networkhttps://string-db.org/network/9606.ENSP00000384421Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in tw [...]
KIF24 protein networkhttps://string-db.org/network/9606.ENSP00000384433Kinesin-like protein KIF24; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading [...]
ZGLP1 protein networkhttps://string-db.org/network/9606.ENSP00000384434GATA-type zinc finger protein 1; Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription fa [...]
HYPK protein networkhttps://string-db.org/network/9606.ENSP00000384474Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Regul [...]
IFRD1 protein networkhttps://string-db.org/network/9606.ENSP00000384477Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that at [...]
ADCY3 protein networkhttps://string-db.org/network/9606.ENSP00000384484Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its func [...]
CBX6 protein networkhttps://string-db.org/network/9606.ENSP00000384490Chromobox protein homolog 6; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
RASSF8 protein networkhttps://string-db.org/network/9606.ENSP00000384491Ras association domain family member 8.
ABCG5 protein networkhttps://string-db.org/network/9606.ENSP00000384513ATP-binding cassette sub-family G member 5; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role [...]
PARVB protein networkhttps://string-db.org/network/9606.ENSP00000384515Beta-parvin; Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorg [...]
ARNTL protein networkhttps://string-db.org/network/9606.ENSP00000384517Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, [...]
ETV2 protein networkhttps://string-db.org/network/9606.ENSP00000384524ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
ZBTB40 protein networkhttps://string-db.org/network/9606.ENSP00000384527Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation.
AKAP12 protein networkhttps://string-db.org/network/9606.ENSP00000384537A-kinase anchor protein 12; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
BTBD3 protein networkhttps://string-db.org/network/9606.ENSP00000384545BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopica [...]
NXPH1 protein networkhttps://string-db.org/network/9606.ENSP00000384551Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family.
OR6B2 protein networkhttps://string-db.org/network/9606.ENSP00000384563Olfactory receptor 6B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SELENOM protein networkhttps://string-db.org/network/9606.ENSP00000384564Selenoprotein M; May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation; Belongs to the selenoprotein M/F family.
CARD10 protein networkhttps://string-db.org/network/9606.ENSP00000384570Caspase recruitment domain-containing protein 10; Activates NF-kappa-B via BCL10 and IKK.
DAZ1 protein networkhttps://string-db.org/network/9606.ENSP00000384573Deleted in azoospermia protein 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-ce [...]
ADGRV1 protein networkhttps://string-db.org/network/9606.ENSP00000384582Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-prot [...]
CYP4F11 protein networkhttps://string-db.org/network/9606.ENSP00000384588Cytochrome P450 4F11; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins). Mechanistica [...]
GAREM2 protein networkhttps://string-db.org/network/9606.ENSP00000384593GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs [...]
GTF2A1L protein networkhttps://string-db.org/network/9606.ENSP00000384597TFIIA-alpha and beta-like factor; May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows [...]
ALKAL2 protein networkhttps://string-db.org/network/9606.ENSP00000384604ALK and LTK ligand 2; Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.
PNPLA7 protein networkhttps://string-db.org/network/9606.ENSP00000384610Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
STON1 protein networkhttps://string-db.org/network/9606.ENSP00000384615Stonin-1; May be involved in the endocytic machinery.
SLC49A3 protein networkhttps://string-db.org/network/9606.ENSP00000384616Solute carrier family 49 member 3; Belongs to the major facilitator superfamily.
DQX1 protein networkhttps://string-db.org/network/9606.ENSP00000384621ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1.
NLK protein networkhttps://string-db.org/network/9606.ENSP00000384625Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canon [...]
KMT5A protein networkhttps://string-db.org/network/9606.ENSP00000384629N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K [...]
CTNNA2 protein networkhttps://string-db.org/network/9606.ENSP00000384638Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Requir [...]
MTMR3 protein networkhttps://string-db.org/network/9606.ENSP00000384651Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-b [...]
PSTK protein networkhttps://string-db.org/network/9606.ENSP00000384653L-seryl-tRNA(Sec) kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis.
C22orf23 protein networkhttps://string-db.org/network/9606.ENSP00000384667UPF0193 protein EVG1; Chromosome 22 open reading frame 23.
KIAA1210 protein networkhttps://string-db.org/network/9606.ENSP00000384670Acrosomal protein KIAA1210; KIAA1210.
SOS1 protein networkhttps://string-db.org/network/9606.ENSP00000384675Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic compon [...]
RNASE9 protein networkhttps://string-db.org/network/9606.ENSP00000384683Inactive ribonuclease-like protein 9; Does not exhibit any ribonuclease activity. Belongs to the pancreatic ribonuclease family.
MMD2 protein networkhttps://string-db.org/network/9606.ENSP00000384690Monocyte to macrophage differentiation associated 2.
PAPOLB protein networkhttps://string-db.org/network/9606.ENSP00000384700poly(A) polymerase beta.
FSHR protein networkhttps://string-db.org/network/9606.ENSP00000384708Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signa [...]
ZDHHC8 protein networkhttps://string-db.org/network/9606.ENSP00000384716Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 s [...]
VSNL1 protein networkhttps://string-db.org/network/9606.ENSP00000384719Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family.
PRDM6 protein networkhttps://string-db.org/network/9606.ENSP00000384725Putative histone-lysine N-methyltransferase PRDM6; Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from diffe [...]
DERL3 protein networkhttps://string-db.org/network/9606.ENSP00000384744Derlin-3; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel [...]
SLC8A1 protein networkhttps://string-db.org/network/9606.ENSP00000384763Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) leve [...]
RSPH10B2 protein networkhttps://string-db.org/network/9606.ENSP00000384766Radial spoke head 10 homolog B2.
PSG4 protein networkhttps://string-db.org/network/9606.ENSP00000384770Pregnancy specific beta-1-glycoprotein 4.
WDR62 protein networkhttps://string-db.org/network/9606.ENSP00000384792WD repeat-containing protein 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. Plays a role in mother-centriole-dependent centriole duplication [...]
A4GALT protein networkhttps://string-db.org/network/9606.ENSP00000384794Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18: [...]
PCNX4 protein networkhttps://string-db.org/network/9606.ENSP00000384801Pecanex-like protein 4; Pecanex 4; Belongs to the pecanex family.
FBXO11 protein networkhttps://string-db.org/network/9606.ENSP00000384823F-box only protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...]
PSD protein networkhttps://string-db.org/network/9606.ENSP00000384830PH and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity). Belongs to the PSD family.
FAM104A protein networkhttps://string-db.org/network/9606.ENSP00000384832Protein FAM104A; Family with sequence similarity 104 member A; Belongs to the FAM104 family.
PRR5 protein networkhttps://string-db.org/network/9606.ENSP00000384848Proline-rich protein 5; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be [...]
CDKN1A protein networkhttps://string-db.org/network/9606.ENSP00000384849Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, [...]
ESRRA protein networkhttps://string-db.org/network/9606.ENSP00000384851Steroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase [...]
XPO1 protein networkhttps://string-db.org/network/9606.ENSP00000384863Exportin-1; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperative [...]
CLHC1 protein networkhttps://string-db.org/network/9606.ENSP00000384869Clathrin heavy chain linker domain containing 1.
ABCB5 protein networkhttps://string-db.org/network/9606.ENSP00000384881ATP-binding cassette sub-family B member 5; Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of th [...]
IFI30 protein networkhttps://string-db.org/network/9606.ENSP00000384886Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal d [...]
CEACAM19 protein networkhttps://string-db.org/network/9606.ENSP00000384887CEA cell adhesion molecule 19; Belongs to the immunoglobulin superfamily. CEA family.
AQP12B protein networkhttps://string-db.org/network/9606.ENSP00000384894Aquaporin-12B; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
GATAD2A protein networkhttps://string-db.org/network/9606.ENSP00000384899Transcriptional repressor p66-alpha; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
SAA1 protein networkhttps://string-db.org/network/9606.ENSP00000384906Serum amyloid protein A(2-102); Major acute phase protein; Belongs to the SAA family.
RTL10 protein networkhttps://string-db.org/network/9606.ENSP00000384924Protein Bop; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signal [...]
GPR12 protein networkhttps://string-db.org/network/9606.ENSP00000384932G-protein coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP pr [...]
PYCR1 protein networkhttps://string-db.org/network/9606.ENSP00000384949Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Invol [...]
SULT6B1 protein networkhttps://string-db.org/network/9606.ENSP00000384950Sulfotransferase 6B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyro [...]
MRPS12 protein networkhttps://string-db.org/network/9606.ENSP00000384952Mitochondrial ribosomal protein S12.
F11 protein networkhttps://string-db.org/network/9606.ENSP00000384957Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
TMPRSS6 protein networkhttps://string-db.org/network/9606.ENSP00000384964Transmembrane protease serine 6; Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator [...]
IMMP2L protein networkhttps://string-db.org/network/9606.ENSP00000384966Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into th [...]
LRRC72 protein networkhttps://string-db.org/network/9606.ENSP00000384971Leucine-rich repeat-containing protein 72; Leucine rich repeat containing 72.
CHCHD10 protein networkhttps://string-db.org/network/9606.ENSP00000384973Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure.
TBC1D10A protein networkhttps://string-db.org/network/9606.ENSP00000384996TBC1 domain family member 10A; Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.
P4HA2 protein networkhttps://string-db.org/network/9606.ENSP00000384999Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
KIF2A protein networkhttps://string-db.org/network/9606.ENSP00000385000Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progre [...]
THAP4 protein networkhttps://string-db.org/network/9606.ENSP00000385006THAP domain containing 4.
CACNA1I protein networkhttps://string-db.org/network/9606.ENSP00000385019Voltage-dependent T-type calcium channel subunit alpha-1I; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...]
FANCL protein networkhttps://string-db.org/network/9606.ENSP00000385021E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitina [...]
SMCR8 protein networkhttps://string-db.org/network/9606.ENSP00000385025Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9 [...]
CHRNA2 protein networkhttps://string-db.org/network/9606.ENSP00000385026Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
SLC22A23 protein networkhttps://string-db.org/network/9606.ENSP00000385028Solute carrier family 22 member 23.
C1S protein networkhttps://string-db.org/network/9606.ENSP00000385035Complement C1s subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r act [...]
HORMAD2 protein networkhttps://string-db.org/network/9606.ENSP00000385055HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the [...]
APOBEC3G protein networkhttps://string-db.org/network/9606.ENSP00000385057DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
FAH protein networkhttps://string-db.org/network/9606.ENSP00000385080Fumarylacetoacetase; Fumarylacetoacetate hydrolase.
TMEM196 protein networkhttps://string-db.org/network/9606.ENSP00000385087Transmembrane protein 196.
TMEM45A protein networkhttps://string-db.org/network/9606.ENSP00000385089Transmembrane protein 45A.
KCTD17 protein networkhttps://string-db.org/network/9606.ENSP00000385096BTB/POZ domain-containing protein KCTD17; Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate- adapter for CUL3-RING [...]
FLACC1 protein networkhttps://string-db.org/network/9606.ENSP00000385098Flagellum-associated coiled-coil domain-containing protein 1; Flagellum associated containing coiled-coil domains 1.
ZNF792 protein networkhttps://string-db.org/network/9606.ENSP00000385099Zinc finger protein 792; May be involved in transcriptional regulation.
MIEF1 protein networkhttps://string-db.org/network/9606.ENSP00000385110Mitochondrial dynamics protein MID51; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related [...]
PRR16 protein networkhttps://string-db.org/network/9606.ENSP00000385118Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those [...]
NRXN1 protein networkhttps://string-db.org/network/9606.ENSP00000385142Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have [...]
UNC5D protein networkhttps://string-db.org/network/9606.ENSP00000385143Netrin receptor UNC5D; Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cel [...]
FAM161A protein networkhttps://string-db.org/network/9606.ENSP00000385158Protein FAM161A; Involved in ciliogenesis.
ZNF155 protein networkhttps://string-db.org/network/9606.ENSP00000385163Zinc finger protein 155; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
R3HDM2 protein networkhttps://string-db.org/network/9606.ENSP00000385169R3H domain containing 2.
PICK1 protein networkhttps://string-db.org/network/9606.ENSP00000385205PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the [...]
GAL3ST1 protein networkhttps://string-db.org/network/9606.ENSP00000385207Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catal [...]
CEP162 protein networkhttps://string-db.org/network/9606.ENSP00000385215Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the dista [...]
NCOA1 protein networkhttps://string-db.org/network/9606.ENSP00000385216Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the c [...]
LARGE2 protein networkhttps://string-db.org/network/9606.ENSP00000385235LARGE xylosyl- and glucuronyltransferase 2; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phospho [...]
CAPN14 protein networkhttps://string-db.org/network/9606.ENSP00000385247Calpain-14; Calcium-regulated non-lysosomal thiol-protease.
ELAVL1 protein networkhttps://string-db.org/network/9606.ENSP00000385269ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNA [...]
ELFN2 protein networkhttps://string-db.org/network/9606.ENSP00000385277Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.
RNF32 protein networkhttps://string-db.org/network/9606.ENSP00000385285RING finger protein 32; May play a role in sperm formation.
CLDN15 protein networkhttps://string-db.org/network/9606.ENSP00000385300Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers [...]
SLC25A19 protein networkhttps://string-db.org/network/9606.ENSP00000385312Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
MAD1L1 protein networkhttps://string-db.org/network/9606.ENSP00000385334Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plat [...]
TAPT1 protein networkhttps://string-db.org/network/9606.ENSP00000385347Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extra [...]
CCDC157 protein networkhttps://string-db.org/network/9606.ENSP00000385357Coiled-coil domain containing 157.
VPREB1 protein networkhttps://string-db.org/network/9606.ENSP00000385361Immunoglobulin iota chain; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in [...]
PDIA6 protein networkhttps://string-db.org/network/9606.ENSP00000385385Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensor [...]
NOLC1 protein networkhttps://string-db.org/network/9606.ENSP00000385410Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and mod [...]
GAGE10 protein networkhttps://string-db.org/network/9606.ENSP00000385415G antigen 10; Belongs to the GAGE family.
NLRC4 protein networkhttps://string-db.org/network/9606.ENSP00000385428NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome [...]
SAR1B protein networkhttps://string-db.org/network/9606.ENSP00000385432GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the [...]
RSPH10B protein networkhttps://string-db.org/network/9606.ENSP00000385443Radial spoke head 10 homolog B.
MAGI1 protein networkhttps://string-db.org/network/9606.ENSP00000385450Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating [...]
MDK protein networkhttps://string-db.org/network/9606.ENSP00000385451Midkine; Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non- proteoglycan receptors. Binds cell-surface proteoglycan r [...]
CGREF1 protein networkhttps://string-db.org/network/9606.ENSP00000385452Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
TFDP3 protein networkhttps://string-db.org/network/9606.ENSP00000385461Transcription factor Dp family member 3; Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase; Belongs to the E2F/DP fa [...]
TNFSF18 protein networkhttps://string-db.org/network/9606.ENSP00000385470Tumor necrosis factor ligand superfamily member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T- cell activat [...]
CLDN5 protein networkhttps://string-db.org/network/9606.ENSP00000385477Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space.
CRPPA protein networkhttps://string-db.org/network/9606.ENSP00000385478D-ribitol-5-phosphate cytidylyltransferase; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. C [...]
H3C15 protein networkhttps://string-db.org/network/9606.ENSP00000385479H3 clustered histone 15.
SYCE3 protein networkhttps://string-db.org/network/9606.ENSP00000385480Synaptonemal complex central element protein 3; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...]
TMEM211 protein networkhttps://string-db.org/network/9606.ENSP00000385494Transmembrane protein 211.
GPSM2 protein networkhttps://string-db.org/network/9606.ENSP00000385510G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during meta [...]
CD14 protein networkhttps://string-db.org/network/9606.ENSP00000385519Monocyte differentiation antigen CD14, membrane-bound form; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR [...]
PPARA protein networkhttps://string-db.org/network/9606.ENSP00000385523Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn- glycerol-3- [...]
KIF26B protein networkhttps://string-db.org/network/9606.ENSP00000385545Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by inter [...]
HIPK2 protein networkhttps://string-db.org/network/9606.ENSP00000385571Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a co [...]
KIAA1841 protein networkhttps://string-db.org/network/9606.ENSP00000385579Uncharacterized protein KIAA1841; KIAA1841.
HOXD12 protein networkhttps://string-db.org/network/9606.ENSP00000385586Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
IGSF23 protein networkhttps://string-db.org/network/9606.ENSP00000385592Immunoglobulin superfamily member 23.
MEX3C protein networkhttps://string-db.org/network/9606.ENSP00000385610RNA-binding E3 ubiquitin-protein ligase MEX3C; E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates [...]
SUN2 protein networkhttps://string-db.org/network/9606.ENSP00000385616SUN domain-containing protein 2; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nu [...]
PDE7A protein networkhttps://string-db.org/network/9606.ENSP00000385632High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle [...]
OBSL1 protein networkhttps://string-db.org/network/9606.ENSP00000385636Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it co [...]
IL6 protein networkhttps://string-db.org/network/9606.ENSP00000385675Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-se [...]
HERC3 protein networkhttps://string-db.org/network/9606.ENSP00000385684Probable E3 ubiquitin-protein ligase HERC3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...]
GRAMD4 protein networkhttps://string-db.org/network/9606.ENSP00000385689GRAM domain-containing protein 4; Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. [...]
SEC14L6 protein networkhttps://string-db.org/network/9606.ENSP00000385695Putative SEC14-like protein 6; SEC14 like lipid binding 6.
PSG2 protein networkhttps://string-db.org/network/9606.ENSP00000385706Pregnancy specific beta-1-glycoprotein 2.
DDT-2 protein networkhttps://string-db.org/network/9606.ENSP00000385714D-dopachrome decarboxylase.
GGT2 protein networkhttps://string-db.org/network/9606.ENSP00000385721Inactive glutathione hydrolase 2; Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically a [...]
INTS1 protein networkhttps://string-db.org/network/9606.ENSP00000385722Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
POLR2F protein networkhttps://string-db.org/network/9606.ENSP00000385725DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...]
MAST4 protein networkhttps://string-db.org/network/9606.ENSP00000385727Microtubule associated serine/threonine kinase family member 4; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
CEACAM21 protein networkhttps://string-db.org/network/9606.ENSP00000385739CEA cell adhesion molecule 21; Belongs to the immunoglobulin superfamily. CEA family.
APOBEC3H protein networkhttps://string-db.org/network/9606.ENSP00000385741DNA dC->dU-editing enzyme APOBEC-3H; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent [...]
SMS protein networkhttps://string-db.org/network/9606.ENSP00000385746Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM).
PRKAR1B protein networkhttps://string-db.org/network/9606.ENSP00000385749cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
MARK2 protein networkhttps://string-db.org/network/9606.ENSP00000385751Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 a [...]
BLVRA protein networkhttps://string-db.org/network/9606.ENSP00000385757Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
PTGR1 protein networkhttps://string-db.org/network/9606.ENSP00000385763Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similar [...]
DGKB protein networkhttps://string-db.org/network/9606.ENSP00000385780Diacylglycerol kinase beta; Exhibits high phosphorylation activity for long-chain diacylglycerols.
POP1 protein networkhttps://string-db.org/network/9606.ENSP00000385787Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribo [...]
PHF14 protein networkhttps://string-db.org/network/9606.ENSP00000385795PHD finger protein 14.
KIF3A protein networkhttps://string-db.org/network/9606.ENSP00000385808Kinesin-like protein KIF3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. [...]
RPAIN protein networkhttps://string-db.org/network/9606.ENSP00000385814RPA-interacting protein; Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA comple [...]
MTA3 protein networkhttps://string-db.org/network/9606.ENSP00000385823Metastasis-associated protein MTA3; Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and [...]
TST protein networkhttps://string-db.org/network/9606.ENSP00000385828Thiosulfate sulfurtransferase; Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur i [...]
TF protein networkhttps://string-db.org/network/9606.ENSP00000385834Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transp [...]
CALHM4 protein networkhttps://string-db.org/network/9606.ENSP00000385836Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel.
PARD3B protein networkhttps://string-db.org/network/9606.ENSP00000385848Partitioning defective 3 homolog B; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions [...]
SETD5 protein networkhttps://string-db.org/network/9606.ENSP00000385852Histone-lysine N-methyltransferase SETD5; Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 in vitro. The physiological significance of this activity is unclear [...]
DUSP28 protein networkhttps://string-db.org/network/9606.ENSP00000385885Dual specificity phosphatase 28; Has phosphatase activity with the synthetic substrate 6,8- difluoro-4-methylumbelliferyl phosphate (in vitro). Has almost no detectable activity with phosphotyros [...]
RASGRP3 protein networkhttps://string-db.org/network/9606.ENSP00000385886Ras guanyl-releasing protein 3; Guanine nucleotide exchange factor (GEF) for Ras and Rap1.
ANKMY1 protein networkhttps://string-db.org/network/9606.ENSP00000385887Ankyrin repeat and MYND domain containing 1.
PLEKHB2 protein networkhttps://string-db.org/network/9606.ENSP00000385892Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes.
SDK1 protein networkhttps://string-db.org/network/9606.ENSP00000385899Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promote [...]
DNASE1 protein networkhttps://string-db.org/network/9606.ENSP00000385905Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-fre [...]
NUCB1 protein networkhttps://string-db.org/network/9606.ENSP00000385923Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to a [...]
RMDN1 protein networkhttps://string-db.org/network/9606.ENSP00000385927Regulator of microtubule dynamics 1.
DCDC1 protein networkhttps://string-db.org/network/9606.ENSP00000385936Doublecortin domain-containing protein 1; Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytoki [...]
ZNF12 protein networkhttps://string-db.org/network/9606.ENSP00000385939Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.
KBTBD12 protein networkhttps://string-db.org/network/9606.ENSP00000385957Kelch repeat and BTB domain containing 12.
RPS14 protein networkhttps://string-db.org/network/9606.ENSP00000385958Ribosomal protein S14.
KCNS3 protein networkhttps://string-db.org/network/9606.ENSP00000385968Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...]
FASTKD2 protein networkhttps://string-db.org/network/9606.ENSP00000385990FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consis [...]
THADA protein networkhttps://string-db.org/network/9606.ENSP00000385995Thyroid adenoma-associated protein; THADA armadillo repeat containing; Belongs to the THADA family.
MS4A15 protein networkhttps://string-db.org/network/9606.ENSP00000386022Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex.
BUD31 protein networkhttps://string-db.org/network/9606.ENSP00000386023Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity.
GABRR2 protein networkhttps://string-db.org/network/9606.ENSP00000386029Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...]
MYH6 protein networkhttps://string-db.org/network/9606.ENSP00000386041Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
LTBP1 protein networkhttps://string-db.org/network/9606.ENSP00000386043Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent [...]
MBD5 protein networkhttps://string-db.org/network/9606.ENSP00000386049Methyl-CpG-binding domain protein 5; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).
ADRA2C protein networkhttps://string-db.org/network/9606.ENSP00000386069Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins; Belongs to the G-protein coupled re [...]
MYO18B protein networkhttps://string-db.org/network/9606.ENSP00000386096Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle spec [...]
CPE protein networkhttps://string-db.org/network/9606.ENSP00000386104Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues f [...]
TEX33 protein networkhttps://string-db.org/network/9606.ENSP00000386118Testis-expressed protein 33; Testis expressed 33.
ARMC5 protein networkhttps://string-db.org/network/9606.ENSP00000386125Armadillo repeat-containing protein 5; Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a ro [...]
UMODL1 protein networkhttps://string-db.org/network/9606.ENSP00000386126Uromodulin like 1.
POM121L12 protein networkhttps://string-db.org/network/9606.ENSP00000386133POM121-like protein 12; POM121 transmembrane nucleoporin like 12; Belongs to the POM121 family.
NGDN protein networkhttps://string-db.org/network/9606.ENSP00000386134Neuroguidin; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs; Belongs to the SAS10 family.
DAPK1 protein networkhttps://string-db.org/network/9606.ENSP00000386135Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regu [...]
XKR9 protein networkhttps://string-db.org/network/9606.ENSP00000386141XK-related protein 9; XK related 9.
HEPN1 protein networkhttps://string-db.org/network/9606.ENSP00000386143Putative cancer susceptibility gene HEPN1 protein; Hepatocellular carcinoma, down-regulated 1.
C6orf226 protein networkhttps://string-db.org/network/9606.ENSP00000386146Uncharacterized protein C6orf226; Chromosome 6 open reading frame 226.
PYM1 protein networkhttps://string-db.org/network/9606.ENSP00000386156Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a position [...]
LCNL1 protein networkhttps://string-db.org/network/9606.ENSP00000386162Lipocalin-like 1 protein; Lipocalin like 1; Belongs to the calycin superfamily. Lipocalin family.
CEBPD protein networkhttps://string-db.org/network/9606.ENSP00000386165CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many e [...]
TBX20 protein networkhttps://string-db.org/network/9606.ENSP00000386170T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenoty [...]
OR3A2 protein networkhttps://string-db.org/network/9606.ENSP00000386180Olfactory receptor 3A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TTC30B protein networkhttps://string-db.org/network/9606.ENSP00000386181Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are tra [...]
ZBED8 protein networkhttps://string-db.org/network/9606.ENSP00000386184Protein ZBED8; Zinc finger BED-type containing 8.
TIGD1 protein networkhttps://string-db.org/network/9606.ENSP00000386186Tigger transposable element derived 1.
C2orf16 protein networkhttps://string-db.org/network/9606.ENSP00000386190Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16.
FOXP2 protein networkhttps://string-db.org/network/9606.ENSP00000386200Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal an [...]
TAS2R41 protein networkhttps://string-db.org/network/9606.ENSP00000386201Taste receptor type 2 member 41; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
HMSD protein networkhttps://string-db.org/network/9606.ENSP00000386207Serpin-like protein HMSD; Putative serine protease inhibitor.
OR2A2 protein networkhttps://string-db.org/network/9606.ENSP00000386209Olfactory receptor 2A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TAS2R40 protein networkhttps://string-db.org/network/9606.ENSP00000386210Taste receptor type 2 member 40; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calci [...]
PSMB11 protein networkhttps://string-db.org/network/9606.ENSP00000386212Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the le [...]
MYO3B protein networkhttps://string-db.org/network/9606.ENSP00000386213Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear ha [...]
C3orf36 protein networkhttps://string-db.org/network/9606.ENSP00000386219Uncharacterized protein C3orf36.
OR2F2 protein networkhttps://string-db.org/network/9606.ENSP00000386222Olfactory receptor 2F2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RBM34 protein networkhttps://string-db.org/network/9606.ENSP00000386226RNA binding motif protein 34.
MCC protein networkhttps://string-db.org/network/9606.ENSP00000386227Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cel [...]
RGS14 protein networkhttps://string-db.org/network/9606.ENSP00000386229Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...]
C19orf73 protein networkhttps://string-db.org/network/9606.ENSP00000386230Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73.
TONSL protein networkhttps://string-db.org/network/9606.ENSP00000386239Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is re [...]
ELMOD3 protein networkhttps://string-db.org/network/9606.ENSP00000386248ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity.
TMEM237 protein networkhttps://string-db.org/network/9606.ENSP00000386264Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family.
SLC38A11 protein networkhttps://string-db.org/network/9606.ENSP00000386272Putative sodium-coupled neutral amino acid transporter 11; Putative sodium-dependent amino acid/proton antiporter.
CNPPD1 protein networkhttps://string-db.org/network/9606.ENSP00000386277Protein CNPPD1; Cyclin Pas1/PHO80 domain containing 1.
APOL6 protein networkhttps://string-db.org/network/9606.ENSP00000386280Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
ALAD protein networkhttps://string-db.org/network/9606.ENSP00000386284Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes t [...]
GULP1 protein networkhttps://string-db.org/network/9606.ENSP00000386289PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholestero [...]
NEMP2 protein networkhttps://string-db.org/network/9606.ENSP00000386292Nuclear envelope integral membrane protein 2; Belongs to the NEMP family.
C2orf76 protein networkhttps://string-db.org/network/9606.ENSP00000386302UPF0538 protein C2orf76; Chromosome 2 open reading frame 76; Belongs to the UPF0538 family.
SCN9A protein networkhttps://string-db.org/network/9606.ENSP00000386306Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
MYO7A protein networkhttps://string-db.org/network/9606.ENSP00000386331Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous [...]
SAPCD2 protein networkhttps://string-db.org/network/9606.ENSP00000386348Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By s [...]
KRTAP19-3 protein networkhttps://string-db.org/network/9606.ENSP00000386376Keratin-associated protein 19-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
CD207 protein networkhttps://string-db.org/network/9606.ENSP00000386378C-type lectin domain family 4 member K; Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superim [...]
IL1R1 protein networkhttps://string-db.org/network/9606.ENSP00000386380Interleukin-1 receptor type 1, membrane form; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 recep [...]
PXMP4 protein networkhttps://string-db.org/network/9606.ENSP00000386385Peroxisomal membrane protein 4.
KLHL30 protein networkhttps://string-db.org/network/9606.ENSP00000386389Kelch-like protein 30; Kelch like family member 30.
ANKRD30BL protein networkhttps://string-db.org/network/9606.ENSP00000386398Putative ankyrin repeat domain-containing protein 30B-like; Ankyrin repeat domain 30B like.
RAD21L1 protein networkhttps://string-db.org/network/9606.ENSP00000386414Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required duri [...]
MZT2B protein networkhttps://string-db.org/network/9606.ENSP00000386419Mitotic spindle organizing protein 2B.
ZNF638 protein networkhttps://string-db.org/network/9606.ENSP00000386433Zinc finger protein 638; Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral [...]
SYNC protein networkhttps://string-db.org/network/9606.ENSP00000386439Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facili [...]
TGOLN2 protein networkhttps://string-db.org/network/9606.ENSP00000386443Trans-Golgi network integral membrane protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network.
SAG protein networkhttps://string-db.org/network/9606.ENSP00000386444S-arrestin; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role [...]
LLCFC1 protein networkhttps://string-db.org/network/9606.ENSP00000386450LLLL and CFNLAS motif containing 1.
MEIOC protein networkhttps://string-db.org/network/9606.ENSP00000386452Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing [...]
CYSRT1 protein networkhttps://string-db.org/network/9606.ENSP00000386453Cysteine rich tail 1.
AAK1 protein networkhttps://string-db.org/network/9606.ENSP00000386456AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP [...]
PRPF40A protein networkhttps://string-db.org/network/9606.ENSP00000386458Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Play [...]
COA8 protein networkhttps://string-db.org/network/9606.ENSP00000386485Cytochrome c oxidase assembly factor 8; Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component [...]
ZC3H8 protein networkhttps://string-db.org/network/9606.ENSP00000386488Zinc finger CCCH domain-containing protein 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the n [...]
HOXD3 protein networkhttps://string-db.org/network/9606.ENSP00000386498Homeobox protein Hox-D3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PRR35 protein networkhttps://string-db.org/network/9606.ENSP00000386499Proline-rich protein 35; Proline rich 35.
ANKRD61 protein networkhttps://string-db.org/network/9606.ENSP00000386502Ankyrin repeat domain 61.
CCDC141 protein networkhttps://string-db.org/network/9606.ENSP00000386503Coiled-coil domain-containing protein 141; Plays a critical role in radial migration and centrosomal function.
RAD54L2 protein networkhttps://string-db.org/network/9606.ENSP00000386520Helicase ARIP4; DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity); Belongs [...]
SMPD4 protein networkhttps://string-db.org/network/9606.ENSP00000386531Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. May sensitize cells to DNA damage-induced apoptosis.
ASB18 protein networkhttps://string-db.org/network/9606.ENSP00000386532Ankyrin repeat and SOCS box protein 18; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
TBC1D10B protein networkhttps://string-db.org/network/9606.ENSP00000386538TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.
PSMD14 protein networkhttps://string-db.org/network/9606.ENSP0000038654126S proteasome non-ATPase regulatory subunit 14; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...]
PREPL protein networkhttps://string-db.org/network/9606.ENSP00000386543Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. Regulates trans-Golgi network morphol [...]
FAM174C protein networkhttps://string-db.org/network/9606.ENSP00000386557Protein FAM174C; Family with sequence similarity 174 member C.
CD8A protein networkhttps://string-db.org/network/9606.ENSP00000386559T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external an [...]
MORN2 protein networkhttps://string-db.org/network/9606.ENSP00000386563MORN repeat-containing protein 2; Might have a role in spermatogenesis.
RGPD3 protein networkhttps://string-db.org/network/9606.ENSP00000386588RANBP2 like and GRIP domain containing 3.
PBRM1 protein networkhttps://string-db.org/network/9606.ENSP00000386593Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/S [...]
DPAGT1 protein networkhttps://string-db.org/network/9606.ENSP00000386597UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pat [...]
VSTM5 protein networkhttps://string-db.org/network/9606.ENSP00000386607V-set and transmembrane domain-containing protein 5; Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by [...]
WDR81 protein networkhttps://string-db.org/network/9606.ENSP00000386609WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying [...]
ZC3H12D protein networkhttps://string-db.org/network/9606.ENSP00000386616Probable ribonuclease ZC3H12D; May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association [...]
SSB protein networkhttps://string-db.org/network/9606.ENSP00000386636Lupus La protein; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of [...]
MCFD2 protein networkhttps://string-db.org/network/9606.ENSP00000386651Multiple coagulation factor deficiency protein 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coag [...]
PCDH20-2 protein networkhttps://string-db.org/network/9606.ENSP00000386653Protocadherin-20; Potential calcium-dependent cell-adhesion protein.
RPL36A-HNRNPH2 protein networkhttps://string-db.org/network/9606.ENSP00000386655RPL36A-HNRNPH2 readthrough; Belongs to the eukaryotic ribosomal protein eL42 family.
KDM3A protein networkhttps://string-db.org/network/9606.ENSP00000386660Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dim [...]
MYADML2 protein networkhttps://string-db.org/network/9606.ENSP00000386702Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2.
ATG9A protein networkhttps://string-db.org/network/9606.ENSP00000386710Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore [...]
JAKMIP1 protein networkhttps://string-db.org/network/9606.ENSP00000386711Janus kinase and microtubule-interacting protein 1; Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signali [...]
RPL31 protein networkhttps://string-db.org/network/9606.ENSP00000386717Ribosomal protein L31.
FCHSD2 protein networkhttps://string-db.org/network/9606.ENSP00000386722F-BAR and double SH3 domains protein 2; Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin I [...]
KCMF1 protein networkhttps://string-db.org/network/9606.ENSP00000386738E3 ubiquitin-protein ligase KCMF1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination; Belongs to the KCMF1 family.
CHN1 protein networkhttps://string-db.org/network/9606.ENSP00000386741N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
SETD2 protein networkhttps://string-db.org/network/9606.ENSP00000386759Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is ca [...]
ZC3H6 protein networkhttps://string-db.org/network/9606.ENSP00000386764Zinc finger CCCH-type containing 6.
SLC39A10 protein networkhttps://string-db.org/network/9606.ENSP00000386766Zinc transporter ZIP10; May act as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
GPATCH11 protein networkhttps://string-db.org/network/9606.ENSP00000386772G-patch domain containing 11.
POTEF protein networkhttps://string-db.org/network/9606.ENSP00000386786POTE ankyrin domain family member F; In the C-terminal section; belongs to the actin family.
TMEM131L protein networkhttps://string-db.org/network/9606.ENSP00000386787Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymoc [...]
FAM243A protein networkhttps://string-db.org/network/9606.ENSP00000386791Protein FAM243A; Family with sequence similarity 243 member A; Belongs to the FAM243 family.
SNORC protein networkhttps://string-db.org/network/9606.ENSP00000386804Protein SNORC; Plays a role in the regulation of chondrocyte maturation and postnatal endochondral ossification. May inhibit cell growth stimulation induced by FGF2.
C4orf48 protein networkhttps://string-db.org/network/9606.ENSP00000386807Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48.
RGPD4 protein networkhttps://string-db.org/network/9606.ENSP00000386810RANBP2 like and GRIP domain containing 4.
MARCHF7 protein networkhttps://string-db.org/network/9606.ENSP00000386830E3 ubiquitin-protein ligase MARCHF7; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enz [...]
AFF3 protein networkhttps://string-db.org/network/9606.ENSP00000386834AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA; Belongs to the AF4 family.
XIRP2 protein networkhttps://string-db.org/network/9606.ENSP00000386840Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization. Belongs to the Xin family.
ZNF385B protein networkhttps://string-db.org/network/9606.ENSP00000386845Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis.
TBC1D8 protein networkhttps://string-db.org/network/9606.ENSP00000386856TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s).
ACTG2 protein networkhttps://string-db.org/network/9606.ENSP00000386857Actin, gamma-enteric smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic ce [...]
SH3BP4 protein networkhttps://string-db.org/network/9606.ENSP00000386862SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act [...]
TET3 protein networkhttps://string-db.org/network/9606.ENSP00000386869Methylcytosine dioxygenase TET3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenet [...]
DCDC2B protein networkhttps://string-db.org/network/9606.ENSP00000386870Doublecortin domain containing 2B.
COPS7B protein networkhttps://string-db.org/network/9606.ENSP00000386880COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
DYSF protein networkhttps://string-db.org/network/9606.ENSP00000386881Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocy [...]
CXCR4 protein networkhttps://string-db.org/network/9606.ENSP00000386884C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involv [...]
FHL2 protein networkhttps://string-db.org/network/9606.ENSP00000386892Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor [...]
RBM4 protein networkhttps://string-db.org/network/9606.ENSP00000386894RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site [...]
FAM124B protein networkhttps://string-db.org/network/9606.ENSP00000386895Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family.
ITGA6 protein networkhttps://string-db.org/network/9606.ENSP00000386896Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is invo [...]
PTGES3L protein networkhttps://string-db.org/network/9606.ENSP00000386902Putative protein PTGES3L; Prostaglandin E synthase 3 like.
MEGF11 protein networkhttps://string-db.org/network/9606.ENSP00000386908Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a m [...]
ARHGAP25 protein networkhttps://string-db.org/network/9606.ENSP00000386911Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
KDELR3 protein networkhttps://string-db.org/network/9606.ENSP00000386918ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Gol [...]
TBC1D14 protein networkhttps://string-db.org/network/9606.ENSP00000386921TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peri [...]
LYG1 protein networkhttps://string-db.org/network/9606.ENSP00000386923Lysozyme g1.
UAP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000386935UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1.
ST6GAL2 protein networkhttps://string-db.org/network/9606.ENSP00000386942Beta-galactoside alpha-2,6-sialyltransferase 2; Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6- sialyltransferase act [...]
CAPS2 protein networkhttps://string-db.org/network/9606.ENSP00000386959Calcyphosin-2; Calcyphosine 2.
CATSPERG protein networkhttps://string-db.org/network/9606.ENSP00000386962Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility w [...]
CC2D2B protein networkhttps://string-db.org/network/9606.ENSP00000386988Protein CC2D2B; Coiled-coil and C2 domain containing 2B.
IPO11 protein networkhttps://string-db.org/network/9606.ENSP00000386992Importin-11; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...]
CWC22 protein networkhttps://string-db.org/network/9606.ENSP00000387006Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding [...]
NCAPG2 protein networkhttps://string-db.org/network/9606.ENSP00000387007Condensin-2 complex subunit G2; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid ax [...]
R3HDM1 protein networkhttps://string-db.org/network/9606.ENSP00000387010R3H domain containing 1.
ARHGEF33 protein networkhttps://string-db.org/network/9606.ENSP00000387020Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor.
C5orf52 protein networkhttps://string-db.org/network/9606.ENSP00000387027Uncharacterized protein C5orf52; Chromosome 5 open reading frame 52.
PPM1M protein networkhttps://string-db.org/network/9606.ENSP00000387046Protein phosphatase, Mg2+/Mn2+ dependent 1M.
PLD3 protein networkhttps://string-db.org/network/9606.ENSP000003870505'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentra [...]
TRABD2A protein networkhttps://string-db.org/network/9606.ENSP00000387075Metalloprotease TIKI1; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following [...]
LYPD6B protein networkhttps://string-db.org/network/9606.ENSP00000387077Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent ma [...]
WDSUB1 protein networkhttps://string-db.org/network/9606.ENSP00000387078WD repeat, sterile alpha motif and U-box domain containing 1.
ZNF365 protein networkhttps://string-db.org/network/9606.ENSP00000387091Protein ZNF365; Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. [...]
TPRN protein networkhttps://string-db.org/network/9606.ENSP00000387100Taperin.
ENSP00000387111 protein networkhttps://string-db.org/network/9606.ENSP00000387111Novel LIPT1-MRPL30 readthrough.
CLEC16A protein networkhttps://string-db.org/network/9606.ENSP00000387122Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. Th [...]
ALDH7A1 protein networkhttps://string-db.org/network/9606.ENSP00000387123Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl don [...]
C2orf78 protein networkhttps://string-db.org/network/9606.ENSP00000387124Uncharacterized protein C2orf78; Chromosome 2 open reading frame 78.
NCKAP5 protein networkhttps://string-db.org/network/9606.ENSP00000387128NCK associated protein 5.
THSD7B protein networkhttps://string-db.org/network/9606.ENSP00000387145Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B.
UNC50 protein networkhttps://string-db.org/network/9606.ENSP00000387146Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity).
NPPC protein networkhttps://string-db.org/network/9606.ENSP00000387159C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be va [...]
CPVL protein networkhttps://string-db.org/network/9606.ENSP00000387164Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for [...]
GIGYF2 protein networkhttps://string-db.org/network/9606.ENSP00000387170GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that [...]
POTEJ protein networkhttps://string-db.org/network/9606.ENSP00000387176POTE ankyrin domain family member J; In the N-terminal section; belongs to the POTE family.
PTRH2 protein networkhttps://string-db.org/network/9606.ENSP00000387180Peptidyl-tRNA hydrolase 2, mitochondrial; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family.
PGGHG protein networkhttps://string-db.org/network/9606.ENSP00000387185Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.
SERF2 protein networkhttps://string-db.org/network/9606.ENSP00000387187Small EDRK-rich factor 2; Positive regulator of amyloid protein aggregation and proteotoxicity. Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formatio [...]
CEP19 protein networkhttps://string-db.org/network/9606.ENSP00000387209Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP- bound RABL2B, the CEP1 [...]
IL18R1 protein networkhttps://string-db.org/network/9606.ENSP00000387211Interleukin-18 receptor 1; Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from [...]
NFU1 protein networkhttps://string-db.org/network/9606.ENSP00000387219NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe- 4S] clusters and deliver them to target proteins. Belongs to the NifU famil [...]
LRRTM4 protein networkhttps://string-db.org/network/9606.ENSP00000387228Leucine-rich repeat transmembrane neuronal protein 4; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to exc [...]
RABL2A protein networkhttps://string-db.org/network/9606.ENSP00000387229Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins inclu [...]
GALNT13 protein networkhttps://string-db.org/network/9606.ENSP00000387239Polypeptide N-acetylgalactosaminyltransferase 13; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threo [...]
MAP3K2 protein networkhttps://string-db.org/network/9606.ENSP00000387246Mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K [...]
PCDH20 protein networkhttps://string-db.org/network/9606.ENSP00000387250Protocadherin 20.
PSTPIP2 protein networkhttps://string-db.org/network/9606.ENSP00000387261Proline-serine-threonine phosphatase-interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity).
IMMT protein networkhttps://string-db.org/network/9606.ENSP00000387262MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
SPIRE1 protein networkhttps://string-db.org/network/9606.ENSP00000387266Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibe [...]
MPP4 protein networkhttps://string-db.org/network/9606.ENSP00000387278MAGUK p55 subfamily member 4; May play a role in retinal photoreceptors development.
AGFG1 protein networkhttps://string-db.org/network/9606.ENSP00000387282Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case o [...]
RAB1A protein networkhttps://string-db.org/network/9606.ENSP00000387286Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
TMEM150A protein networkhttps://string-db.org/network/9606.ENSP00000387292Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K comp [...]
ERICH2 protein networkhttps://string-db.org/network/9606.ENSP00000387298Glutamate-rich protein 2; Glutamate rich 2.
TDRD9 protein networkhttps://string-db.org/network/9606.ENSP00000387303ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the ge [...]
RAB6C protein networkhttps://string-db.org/network/9606.ENSP00000387307Ras-related protein Rab-6C; May be involved in the regulation of centrosome duplication and cell cycle progression.
NOTUM protein networkhttps://string-db.org/network/9606.ENSP00000387310Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Ser [...]
NLRX1 protein networkhttps://string-db.org/network/9606.ENSP00000387334NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-M [...]
ACAN protein networkhttps://string-db.org/network/9606.ENSP00000387356Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds [...]
UBE4A protein networkhttps://string-db.org/network/9606.ENSP00000387362Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the [...]
PWP1 protein networkhttps://string-db.org/network/9606.ENSP00000387365Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates [...]
NECAB1 protein networkhttps://string-db.org/network/9606.ENSP00000387380N-terminal EF-hand calcium binding protein 1.
KANSL1 protein networkhttps://string-db.org/network/9606.ENSP00000387393KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...]
ARTN protein networkhttps://string-db.org/network/9606.ENSP00000387435Artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture [...]
ZBTB10 protein networkhttps://string-db.org/network/9606.ENSP00000387462Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation.
CIAO2B protein networkhttps://string-db.org/network/9606.ENSP00000387471Cytosolic iron-sulfur assembly component 2B; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster i [...]
FUT2 protein networkhttps://string-db.org/network/9606.ENSP00000387498Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a [...]
OR7E24 protein networkhttps://string-db.org/network/9606.ENSP00000387523Olfactory receptor 7E24; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
IRGQ protein networkhttps://string-db.org/network/9606.ENSP00000387535Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
SLC18A1 protein networkhttps://string-db.org/network/9606.ENSP00000387549Chromaffin granule amine transporter; Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells.
TANC2 protein networkhttps://string-db.org/network/9606.ENSP00000387593Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines.
SMCO2 protein networkhttps://string-db.org/network/9606.ENSP00000387617Single-pass membrane protein with coiled-coil domains 2.
CAND2 protein networkhttps://string-db.org/network/9606.ENSP00000387641Cullin-associated NEDD8-dissociated protein 2; Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-b [...]
PCYOX1 protein networkhttps://string-db.org/network/9606.ENSP00000387654Prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.
GCG protein networkhttps://string-db.org/network/9606.ENSP00000387662Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulator [...]
UGT2B11 protein networkhttps://string-db.org/network/9606.ENSP00000387683UDP-glucuronosyltransferase 2B11; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyl [...]
SLC12A5 protein networkhttps://string-db.org/network/9606.ENSP00000387694Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chlo [...]
CREB1 protein networkhttps://string-db.org/network/9606.ENSP00000387699Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence prese [...]
TARS1 protein networkhttps://string-db.org/network/9606.ENSP00000387710Threonine--tRNA ligase 1, cytoplasmic; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the [...]
AMOTL1 protein networkhttps://string-db.org/network/9606.ENSP00000387739Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to [...]
HIC2 protein networkhttps://string-db.org/network/9606.ENSP00000387757Hypermethylated in cancer 2 protein; Transcriptional repressor.
BRDT protein networkhttps://string-db.org/network/9606.ENSP00000387822Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role [...]
KIF4B protein networkhttps://string-db.org/network/9606.ENSP00000387875Chromosome-associated kinesin KIF4B; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step f [...]
TC2N protein networkhttps://string-db.org/network/9606.ENSP00000387882Tandem C2 domains, nuclear.
PARN protein networkhttps://string-db.org/network/9606.ENSP00000387911Poly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tai [...]
IFFO2 protein networkhttps://string-db.org/network/9606.ENSP00000387941Intermediate filament family orphan 2; Belongs to the intermediate filament family.
WDR73 protein networkhttps://string-db.org/network/9606.ENSP00000387982WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics.
CSTF2 protein networkhttps://string-db.org/network/9606.ENSP00000387996Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre [...]
OAS1 protein networkhttps://string-db.org/network/9606.ENSP000003880012'-5'-oligoadenylate synthase 1; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in ot [...]
KRBOX1 protein networkhttps://string-db.org/network/9606.ENSP00000388094KRAB box domain containing 1.
UBA52 protein networkhttps://string-db.org/network/9606.ENSP00000388107Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an iso [...]
MPPED1 protein networkhttps://string-db.org/network/9606.ENSP00000388137Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro).
ARPC4 protein networkhttps://string-db.org/network/9606.ENSP00000388169Actin-related protein 2/3 complex subunit 4; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting fact [...]
OGDH protein networkhttps://string-db.org/network/9606.ENSP000003881832-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. T [...]
RNF148 protein networkhttps://string-db.org/network/9606.ENSP00000388207Ring finger protein 148.
KIF26A protein networkhttps://string-db.org/network/9606.ENSP00000388241Kinesin-like protein KIF26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, po [...]
AGBL3 protein networkhttps://string-db.org/network/9606.ENSP00000388275Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generat [...]
TSTD1 protein networkhttps://string-db.org/network/9606.ENSP00000388293Thiosulfate:glutathione sulfurtransferase; Thiosulfate:glutathione sulfurtransferase (TST) required to produce S-sulfanylglutathione (GSS(-)), a central intermediate in hydrogen sulfide metabolis [...]
TRIM49C protein networkhttps://string-db.org/network/9606.ENSP00000388299Tripartite motif containing 49C.
ZNF845 protein networkhttps://string-db.org/network/9606.ENSP00000388311Zinc finger protein 845; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SEC61G protein networkhttps://string-db.org/network/9606.ENSP00000388337Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic [...]
TMEM251 protein networkhttps://string-db.org/network/9606.ENSP00000388431Transmembrane protein 251; Belongs to the TMEM251 family.
ZNF583 protein networkhttps://string-db.org/network/9606.ENSP00000388502Zinc finger protein 583; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RARG protein networkhttps://string-db.org/network/9606.ENSP00000388510Retinoic acid receptor gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic [...]
RNF24 protein networkhttps://string-db.org/network/9606.ENSP00000388550RING finger protein 24; May play a role in TRPCs intracellular trafficking.
RBM14-RBM4 protein networkhttps://string-db.org/network/9606.ENSP00000388552RBM14-RBM4 readthrough.
CASP4 protein networkhttps://string-db.org/network/9606.ENSP00000388566Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non- canonical activators, such as UVB ra [...]
EOMES protein networkhttps://string-db.org/network/9606.ENSP00000388620Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesod [...]
PLCD4 protein networkhttps://string-db.org/network/9606.ENSP000003886311-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and in [...]
RBM17 protein networkhttps://string-db.org/network/9606.ENSP00000388638Splicing factor 45; Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alterna [...]
SLC25A12 protein networkhttps://string-db.org/network/9606.ENSP00000388658Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartat [...]
TMEM247 protein networkhttps://string-db.org/network/9606.ENSP00000388684Transmembrane protein 247.
LANCL1 protein networkhttps://string-db.org/network/9606.ENSP00000388713Glutathione S-transferase LANCL1; Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4- dinitrobenzene (CDNB) and p-nitrophen [...]
KBTBD13 protein networkhttps://string-db.org/network/9606.ENSP00000388723Kelch repeat and BTB domain-containing protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex.
ITPRID2 protein networkhttps://string-db.org/network/9606.ENSP00000388731Protein ITPRID2; ITPR interacting domain containing 2.
RRAD protein networkhttps://string-db.org/network/9606.ENSP00000388744GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channe [...]
ZNF683 protein networkhttps://string-db.org/network/9606.ENSP00000388792Tissue-resident T-cell transcription regulator protein ZNF683; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell [...]
EIF4B protein networkhttps://string-db.org/network/9606.ENSP00000388806Eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presen [...]
NSG1 protein networkhttps://string-db.org/network/9606.ENSP00000388823Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosome [...]
MLN protein networkhttps://string-db.org/network/9606.ENSP00000388825Motilin-associated peptide; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.
PNMA5 protein networkhttps://string-db.org/network/9606.ENSP00000388850Paraneoplastic antigen-like protein 5; PNMA family member 5; Belongs to the PNMA family.
ZNF419 protein networkhttps://string-db.org/network/9606.ENSP00000388864Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SPATA3 protein networkhttps://string-db.org/network/9606.ENSP00000388895Spermatogenesis-associated protein 3; Spermatogenesis associated 3.
CYBC1 protein networkhttps://string-db.org/network/9606.ENSP00000388909Cytochrome b-245 chaperone 1; Necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer. Controls the phagocyte respiratory burst and is essential for in [...]
NFATC4 protein networkhttps://string-db.org/network/9606.ENSP00000388910Nuclear factor of activated T-cells, cytoplasmic 4; Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascul [...]
RWDD4 protein networkhttps://string-db.org/network/9606.ENSP00000388920RWD domain containing 4.
TCF12 protein networkhttps://string-db.org/network/9606.ENSP00000388940Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
SCRN1 protein networkhttps://string-db.org/network/9606.ENSP00000388942Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).
AP1M1 protein networkhttps://string-db.org/network/9606.ENSP00000388996AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate t [...]
CARNS1 protein networkhttps://string-db.org/network/9606.ENSP00000389009Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.
CPLANE1 protein networkhttps://string-db.org/network/9606.ENSP00000389014Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with [...]
SBK2 protein networkhttps://string-db.org/network/9606.ENSP00000389015Serine/threonine-protein kinase SBK2; SH3 domain binding kinase family member 2; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
CRISP3 protein networkhttps://string-db.org/network/9606.ENSP00000389026Cysteine rich secretory protein 3; Belongs to the CRISP family.
MMADHC protein networkhttps://string-db.org/network/9606.ENSP00000389060Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenos [...]
OR10G8 protein networkhttps://string-db.org/network/9606.ENSP00000389072Olfactory receptor 10G8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CYTH1 protein networkhttps://string-db.org/network/9606.ENSP00000389095Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficki [...]
RPL23A protein networkhttps://string-db.org/network/9606.ENSP0000038910360S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promot [...]
FNDC10 protein networkhttps://string-db.org/network/9606.ENSP00000389111Fibronectin type III domain containing 10.
DCC protein networkhttps://string-db.org/network/9606.ENSP00000389140Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with U [...]
NDUFA11 protein networkhttps://string-db.org/network/9606.ENSP00000389160NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...]
PPP1R12A protein networkhttps://string-db.org/network/9606.ENSP00000389168Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Cap [...]
GLYCTK protein networkhttps://string-db.org/network/9606.ENSP00000389175Glycerate kinase; Belongs to the glycerate kinase type-2 family.
C1GALT1 protein networkhttps://string-db.org/network/9606.ENSP00000389176Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for m [...]
RPP30 protein networkhttps://string-db.org/network/9606.ENSP00000389182Ribonuclease P protein subunit p30; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclea [...]
NBPF4 protein networkhttps://string-db.org/network/9606.ENSP00000389237Neuroblastoma breakpoint family member 4; NBPF member 4.
DHRS9 protein networkhttps://string-db.org/network/9606.ENSP00000389241Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha- tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstaned [...]
NPNT protein networkhttps://string-db.org/network/9606.ENSP00000389252Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May als [...]
HCAR1 protein networkhttps://string-db.org/network/9606.ENSP00000389255Hydroxycarboxylic acid receptor 1; Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.
TMBIM6 protein networkhttps://string-db.org/network/9606.ENSP00000389277Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and a [...]
AKR1B15 protein networkhttps://string-db.org/network/9606.ENSP00000389289Aldo-keto reductase family 1 member B15; [Isoform 1]: Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl [...]
CHCHD3 protein networkhttps://string-db.org/network/9606.ENSP00000389297MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
DAZ4 protein networkhttps://string-db.org/network/9606.ENSP00000389300Deleted in azoospermia 4.
ACE2 protein networkhttps://string-db.org/network/9606.ENSP00000389326Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. A [...]
RPSA protein networkhttps://string-db.org/network/9606.ENSP0000038935140S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the [...]
RPL39L protein networkhttps://string-db.org/network/9606.ENSP00000389356Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family.
NFATC1 protein networkhttps://string-db.org/network/9606.ENSP00000389377Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also [...]
YY2 protein networkhttps://string-db.org/network/9606.ENSP00000389381Transcription factor YY2; Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in develop [...]
STK11IP protein networkhttps://string-db.org/network/9606.ENSP00000389383Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization.
GPAT2 protein networkhttps://string-db.org/network/9606.ENSP00000389395Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required f [...]
TMCO3 protein networkhttps://string-db.org/network/9606.ENSP00000389399Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
TBXAS1 protein networkhttps://string-db.org/network/9606.ENSP00000389414Thromboxane A synthase 1; Belongs to the cytochrome P450 family.
CEP44 protein networkhttps://string-db.org/network/9606.ENSP00000389427Centrosomal protein 44.
USP17L12 protein networkhttps://string-db.org/network/9606.ENSP00000389443Ubiquitin carboxyl-terminal hydrolase 17-like protein 12; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
UBAP2L protein networkhttps://string-db.org/network/9606.ENSP00000389445Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).
TGM7 protein networkhttps://string-db.org/network/9606.ENSP00000389466Protein-glutamine gamma-glutamyltransferase Z; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase [...]
CT47A4 protein networkhttps://string-db.org/network/9606.ENSP00000389513Cancer/testis antigen family 47 member A4.
C2CD4D protein networkhttps://string-db.org/network/9606.ENSP00000389554C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D.
SEMA5B protein networkhttps://string-db.org/network/9606.ENSP00000389588Semaphorin-5B; May act as positive axonal guidance cues.
TLR6 protein networkhttps://string-db.org/network/9606.ENSP00000389600Toll-like receptor 6; Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In resp [...]
DPY19L4 protein networkhttps://string-db.org/network/9606.ENSP00000389630Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.
ARPC1B protein networkhttps://string-db.org/network/9606.ENSP00000389631Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The [...]
ATP5PF protein networkhttps://string-db.org/network/9606.ENSP00000389649ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membr [...]
RNF212 protein networkhttps://string-db.org/network/9606.ENSP00000389709Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific reco [...]
CTNNA3 protein networkhttps://string-db.org/network/9606.ENSP00000389714Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes.
KSR2 protein networkhttps://string-db.org/network/9606.ENSP00000389715Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low effi [...]
CYB561A3 protein networkhttps://string-db.org/network/9606.ENSP00000389745Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron don [...]
CASTOR3 protein networkhttps://string-db.org/network/9606.ENSP00000389760CASTOR family member 3; Belongs to the GATS family.
PLEKHF1 protein networkhttps://string-db.org/network/9606.ENSP00000389787Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosoma [...]
DSN1 protein networkhttps://string-db.org/network/9606.ENSP00000389810Kinetochore-associated protein DSN1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.
ACAD10 protein networkhttps://string-db.org/network/9606.ENSP00000389813Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2-methyl- C15-CoA.
ADIPOQ protein networkhttps://string-db.org/network/9606.ENSP00000389814Adiponectin; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK p [...]
ZNF852 protein networkhttps://string-db.org/network/9606.ENSP00000389841Zinc finger protein 852; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DLX3 protein networkhttps://string-db.org/network/9606.ENSP00000389870Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less home [...]
DCUN1D4 protein networkhttps://string-db.org/network/9606.ENSP00000389900DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4.
LETMD1 protein networkhttps://string-db.org/network/9606.ENSP00000389903LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
RCBTB2 protein networkhttps://string-db.org/network/9606.ENSP00000389910RCC1 and BTB domain containing protein 2.
PLEKHM1 protein networkhttps://string-db.org/network/9606.ENSP00000389913Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosom [...]
NT5C3B protein networkhttps://string-db.org/network/9606.ENSP000003899487-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7 [...]
TMEM67 protein networkhttps://string-db.org/network/9606.ENSP00000389998Meckelin; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By simil [...]
CTU1 protein networkhttps://string-db.org/network/9606.ENSP00000390011Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts [...]
CT47A5 protein networkhttps://string-db.org/network/9606.ENSP00000390070Cancer/testis antigen family 47 member A5.
ZSCAN31 protein networkhttps://string-db.org/network/9606.ENSP00000390076Zinc finger and SCAN domain-containing protein 31; May function as a transcription factor. May be involved in the development of multiple embryonic organs; Belongs to the krueppel C2H2-type zinc- [...]
SHISA6 protein networkhttps://string-db.org/network/9606.ENSP00000390084Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic den [...]
PLSCR5 protein networkhttps://string-db.org/network/9606.ENSP00000390111Phospholipid scramblase family member 5; Belongs to the phospholipid scramblase family.
HERC1 protein networkhttps://string-db.org/network/9606.ENSP00000390158Probable E3 ubiquitin-protein ligase HERC1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and [...]
ZNF527 protein networkhttps://string-db.org/network/9606.ENSP00000390179Zinc finger protein 527; May be involved in transcriptional regulation.
HEPACAM2 protein networkhttps://string-db.org/network/9606.ENSP00000390204HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosome [...]
ZBBX protein networkhttps://string-db.org/network/9606.ENSP00000390232Zinc finger B-box domain containing.
IDH1 protein networkhttps://string-db.org/network/9606.ENSP00000390265Isocitrate dehydrogenase 1.
hCG_1984214 protein networkhttps://string-db.org/network/9606.ENSP00000390331HCG1984214, isoform CRA_a.
SPEGNB-2 protein networkhttps://string-db.org/network/9606.ENSP00000390353SPEG neighbor protein.
SLC4A7 protein networkhttps://string-db.org/network/9606.ENSP00000390394Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarb [...]
TMEM213 protein networkhttps://string-db.org/network/9606.ENSP00000390407Transmembrane protein 213.
GPR141 protein networkhttps://string-db.org/network/9606.ENSP00000390410Probable G-protein coupled receptor 141; Orphan receptor; Belongs to the G-protein coupled receptor 1 family.
CATSPER4 protein networkhttps://string-db.org/network/9606.ENSP00000390423Cation channel sperm-associated protein 4; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...]
GLI2 protein networkhttps://string-db.org/network/9606.ENSP00000390436Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor (By similarity) [...]
CXXC1 protein networkhttps://string-db.org/network/9606.ENSP00000390475CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
HSPA14-2 protein networkhttps://string-db.org/network/9606.ENSP00000390513Heat shock 70kDa protein 14 isoform 1 variant 3.
PRKD1 protein networkhttps://string-db.org/network/9606.ENSP00000390535Serine/threonine-protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in [...]
SLC16A5 protein networkhttps://string-db.org/network/9606.ENSP00000390564Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...]
DDN protein networkhttps://string-db.org/network/9606.ENSP00000390590Dendrin; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retentio [...]
SCN10A protein networkhttps://string-db.org/network/9606.ENSP00000390600Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conform [...]
BTNL2 protein networkhttps://string-db.org/network/9606.ENSP00000390613Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family.
TDRD12 protein networkhttps://string-db.org/network/9606.ENSP00000390621Putative ATP-dependent RNA helicase TDRD12; Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essentia [...]
HNRNPLL protein networkhttps://string-db.org/network/9606.ENSP00000390625Heterogeneous nuclear ribonucleoprotein L-like; RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for al [...]
RIMBP3C protein networkhttps://string-db.org/network/9606.ENSP00000390630RIMS-binding protein 3C; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
SLC14A1 protein networkhttps://string-db.org/network/9606.ENSP00000390637Urea transporter 1; Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through w [...]
C12orf65 protein networkhttps://string-db.org/network/9606.ENSP00000390647Probable peptide chain release factor C12orf65, mitochondrial; May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of tr [...]
CLEC2L protein networkhttps://string-db.org/network/9606.ENSP00000390661C-type lectin domain family 2 member L.
SLC25A17 protein networkhttps://string-db.org/network/9606.ENSP00000390722Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine m [...]
SCFD1 protein networkhttps://string-db.org/network/9606.ENSP00000390783Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endopla [...]
B3GALT4 protein networkhttps://string-db.org/network/9606.ENSP00000390784Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis.
LRRC23 protein networkhttps://string-db.org/network/9606.ENSP00000390932Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23.
ATCAY protein networkhttps://string-db.org/network/9606.ENSP00000390941Caytaxin; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GL [...]
GOLGA6D protein networkhttps://string-db.org/network/9606.ENSP00000391085Golgin A6 family member D; Belongs to the GOLGA6 family.
UNC80 protein networkhttps://string-db.org/network/9606.ENSP00000391088Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and e [...]
CHEK1 protein networkhttps://string-db.org/network/9606.ENSP00000391090Serine/threonine-protein kinase Chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA d [...]
SLFN14 protein networkhttps://string-db.org/network/9606.ENSP00000391101C-terminally truncated SLFN14 endoribonuclease; [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities; Belongs to the Schlafen family. Subgroup III subfamily.
RDH13 protein networkhttps://string-db.org/network/9606.ENSP00000391121Retinol dehydrogenase 13; Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity to [...]
ASB10 protein networkhttps://string-db.org/network/9606.ENSP00000391137Ankyrin repeat and SOCS box protein 10; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
DENND4A protein networkhttps://string-db.org/network/9606.ENSP00000391167C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into th [...]
ZNF692 protein networkhttps://string-db.org/network/9606.ENSP00000391200Zinc finger protein 692; May be involved in transcriptional regulation.
CYB561D2 protein networkhttps://string-db.org/network/9606.ENSP00000391209Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction.
PSMC2 protein networkhttps://string-db.org/network/9606.ENSP0000039121126S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
MGAT5B protein networkhttps://string-db.org/network/9606.ENSP00000391227Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- a [...]
SEPTIN9 protein networkhttps://string-db.org/network/9606.ENSP00000391249Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria [...]
RBFOX1 protein networkhttps://string-db.org/network/9606.ENSP00000391269RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons a [...]
SAMD7 protein networkhttps://string-db.org/network/9606.ENSP00000391299Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes.
SEPTIN5 protein networkhttps://string-db.org/network/9606.ENSP00000391311Septin-5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity); Belongs to the TRAFAC class TrmE [...]
CT47A12 protein networkhttps://string-db.org/network/9606.ENSP00000391318Cancer/testis antigen family 47 member A12.
ATP6AP1L protein networkhttps://string-db.org/network/9606.ENSP00000391381V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like.
C4orf51 protein networkhttps://string-db.org/network/9606.ENSP00000391404Uncharacterized protein C4orf51; Chromosome 4 open reading frame 51.
CDHR4 protein networkhttps://string-db.org/network/9606.ENSP00000391409Cadherin-related family member 4; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may th [...]
INO80C protein networkhttps://string-db.org/network/9606.ENSP00000391457INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
TKT protein networkhttps://string-db.org/network/9606.ENSP00000391481Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the t [...]
PNMA6A protein networkhttps://string-db.org/network/9606.ENSP00000391488Paraneoplastic antigen-like protein 6A; PNMA family member 6A; Belongs to the PNMA family.
AGR2 protein networkhttps://string-db.org/network/9606.ENSP00000391490Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene [...]
KCNK16 protein networkhttps://string-db.org/network/9606.ENSP00000391498Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.
CCDC173 protein networkhttps://string-db.org/network/9606.ENSP00000391504Coiled-coil domain containing 173.
DENND6B protein networkhttps://string-db.org/network/9606.ENSP00000391524Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; Belongs to the DENND6 family.
SMIM19 protein networkhttps://string-db.org/network/9606.ENSP00000391549Small integral membrane protein 19.
PARVG protein networkhttps://string-db.org/network/9606.ENSP00000391583Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family.
PTPN6 protein networkhttps://string-db.org/network/9606.ENSP00000391592Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with ot [...]
ERV3-1 protein networkhttps://string-db.org/network/9606.ENSP00000391594Endogenous retrovirus group 3 member 1 Env polyprotein; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have [...]
AMDHD2 protein networkhttps://string-db.org/network/9606.ENSP00000391596N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Al [...]
PEX5 protein networkhttps://string-db.org/network/9606.ENSP00000391601Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
ZNF780B protein networkhttps://string-db.org/network/9606.ENSP00000391641Zinc finger protein 780B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MTMR11 protein networkhttps://string-db.org/network/9606.ENSP00000391668Myotubularin related protein 11; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.
BCAR1 protein networkhttps://string-db.org/network/9606.ENSP00000391669Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of [...]
CCDC103 protein networkhttps://string-db.org/network/9606.ENSP00000391692Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. Belongs to the CCDC103/PR46b family.
PUM1 protein networkhttps://string-db.org/network/9606.ENSP00000391723Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Resp [...]
PISD protein networkhttps://string-db.org/network/9606.ENSP00000391739Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid meta [...]
LACC1 protein networkhttps://string-db.org/network/9606.ENSP00000391747Laccase domain-containing protein 1; Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly [...]
PILRB protein networkhttps://string-db.org/network/9606.ENSP00000391748Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PIL [...]
CCDC36 protein networkhttps://string-db.org/network/9606.ENSP00000391788Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114 [...]
APLN protein networkhttps://string-db.org/network/9606.ENSP00000391800Apelin-13; Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR ( [...]
MITF protein networkhttps://string-db.org/network/9606.ENSP00000391803Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-bo [...]
E7ENX8_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000391806Uncharacterized protein.
IGF2 protein networkhttps://string-db.org/network/9606.ENSP00000391826Insulin-like growth factor II Ala-25 Del; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental de [...]
NECAP2 protein networkhttps://string-db.org/network/9606.ENSP00000391942Adaptin ear-binding coat-associated protein 2; Involved in endocytosis.
ZNF844 protein networkhttps://string-db.org/network/9606.ENSP00000392024Zinc finger protein 844; May be involved in transcriptional regulation.
CYLD protein networkhttps://string-db.org/network/9606.ENSP00000392025Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alph [...]
CHD7 protein networkhttps://string-db.org/network/9606.ENSP00000392028Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production.
ATP2B1 protein networkhttps://string-db.org/network/9606.ENSP00000392043Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellula [...]
REPS1 protein networkhttps://string-db.org/network/9606.ENSP00000392065RalBP1-associated Eps domain-containing protein 1; May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.
DIP2A protein networkhttps://string-db.org/network/9606.ENSP00000392066Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system.
EFTUD2 protein networkhttps://string-db.org/network/9606.ENSP00000392094116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. [...]
INAVA protein networkhttps://string-db.org/network/9606.ENSP00000392105Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokin [...]
PPP6C protein networkhttps://string-db.org/network/9606.ENSP00000392147Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed; Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle [...]
KRTAP9-3 protein networkhttps://string-db.org/network/9606.ENSP00000392189Keratin-associated protein 9-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
REEP1 protein networkhttps://string-db.org/network/9606.ENSP00000392197Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surf [...]
KLLN protein networkhttps://string-db.org/network/9606.ENSP00000392204Killin; DNA-binding protein involved in S phase checkpoint control- coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled [...]
AGAP9 protein networkhttps://string-db.org/network/9606.ENSP00000392206ArfGAP with GTPase domain, ankyrin repeat and PH domain 9.
TTLL8 protein networkhttps://string-db.org/network/9606.ENSP00000392252Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of t [...]
PPIL6 protein networkhttps://string-db.org/network/9606.ENSP00000392257Probable inactive peptidyl-prolyl cis-trans isomerase-like 6; Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family.
PPP5D1 protein networkhttps://string-db.org/network/9606.ENSP00000392262Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1.
STRAP protein networkhttps://string-db.org/network/9606.ENSP00000392270Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Th [...]
CT47A7 protein networkhttps://string-db.org/network/9606.ENSP00000392283Cancer/testis antigen family 47 member A7.
KAT14 protein networkhttps://string-db.org/network/9606.ENSP00000392318Cysteine-rich protein 2-binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to [...]
BCAP31 protein networkhttps://string-db.org/network/9606.ENSP00000392330B-cell receptor-associated protein 31; Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER [...]
PSMG4 protein networkhttps://string-db.org/network/9606.ENSP00000392353Proteasome assembly chaperone 4; Chaperone protein which promotes assembly of the 20S proteasome.
CCDC198 protein networkhttps://string-db.org/network/9606.ENSP00000392368Uncharacterized protein CCDC198; Coiled-coil domain containing 198.
ZSCAN30 protein networkhttps://string-db.org/network/9606.ENSP00000392371Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation.
CHFR protein networkhttps://string-db.org/network/9606.ENSP00000392395E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in earl [...]
GPX5 protein networkhttps://string-db.org/network/9606.ENSP00000392398Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glut [...]
PRR20D protein networkhttps://string-db.org/network/9606.ENSP00000392407Proline rich 20D.
ZNF587B protein networkhttps://string-db.org/network/9606.ENSP00000392410Zinc finger protein 587B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SLC13A2 protein networkhttps://string-db.org/network/9606.ENSP00000392411Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
RELN protein networkhttps://string-db.org/network/9606.ENSP00000392423Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affe [...]
TRAPPC2 protein networkhttps://string-db.org/network/9606.ENSP00000392495Trafficking protein particle complex subunit 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic re [...]
NLGN1 protein networkhttps://string-db.org/network/9606.ENSP00000392500Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and pro [...]
PRRT3 protein networkhttps://string-db.org/network/9606.ENSP00000392511Proline rich transmembrane protein 3.
AGAP4 protein networkhttps://string-db.org/network/9606.ENSP00000392513Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.
TTLL3 protein networkhttps://string-db.org/network/9606.ENSP00000392549Tubulin monoglycylase TTLL3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-termi [...]
PLPP5 protein networkhttps://string-db.org/network/9606.ENSP00000392553Phospholipid phosphatase 5; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphati [...]
DEFB130B protein networkhttps://string-db.org/network/9606.ENSP00000392568Defensin beta 130B.
SMARCD2 protein networkhttps://string-db.org/network/9606.ENSP00000392617SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...]
ARHGAP28 protein networkhttps://string-db.org/network/9606.ENSP00000392660Rho GTPase-activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
AKIRIN1 protein networkhttps://string-db.org/network/9606.ENSP00000392678Akirin-1; Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, [...]
AMER3 protein networkhttps://string-db.org/network/9606.ENSP00000392700APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell [...]
NDUFS1 protein networkhttps://string-db.org/network/9606.ENSP00000392709NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal [...]
POTEI protein networkhttps://string-db.org/network/9606.ENSP00000392718POTE ankyrin domain family member I; In the N-terminal section; belongs to the POTE family.
POM121L2 protein networkhttps://string-db.org/network/9606.ENSP00000392726POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family.
ARHGAP11B protein networkhttps://string-db.org/network/9606.ENSP00000392760Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the [...]
DCT protein networkhttps://string-db.org/network/9606.ENSP00000392762L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. Belongs to the ty [...]
S100A13 protein networkhttps://string-db.org/network/9606.ENSP00000392767Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding o [...]
CLGN protein networkhttps://string-db.org/network/9606.ENSP00000392782Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zo [...]
PIK3R5 protein networkhttps://string-db.org/network/9606.ENSP00000392812Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-ga [...]
GPSM1 protein networkhttps://string-db.org/network/9606.ENSP00000392828G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha sub [...]
TCP11X2 protein networkhttps://string-db.org/network/9606.ENSP00000392879T-complex 11 family, X-linked 2; Belongs to the TCP11 family.
HSBP1 protein networkhttps://string-db.org/network/9606.ENSP00000392896Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stres [...]
PLEKHG2 protein networkhttps://string-db.org/network/9606.ENSP00000392906Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC [...]
RFPL4A protein networkhttps://string-db.org/network/9606.ENSP00000392936Ret finger protein like 4A.
HTATIP2 protein networkhttps://string-db.org/network/9606.ENSP00000392985Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear tran [...]
SLC4A10 protein networkhttps://string-db.org/network/9606.ENSP00000393066Sodium-driven chloride bicarbonate exchanger; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransp [...]
GABRA1 protein networkhttps://string-db.org/network/9606.ENSP00000393097Gamma-aminobutyric acid receptor subunit alpha-1; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. [...]
LPAR5 protein networkhttps://string-db.org/network/9606.ENSP00000393098Lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
MAPKBP1 protein networkhttps://string-db.org/network/9606.ENSP00000393099Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as activation of NF-kappa-B signaling, IL8 secretion and an [...]
LHFPL3 protein networkhttps://string-db.org/network/9606.ENSP00000393128LHFPL tetraspan subfamily member 3.
PRAMEF27 protein networkhttps://string-db.org/network/9606.ENSP00000393136PRAME family member 27; Belongs to the PRAME family.
CDC7 protein networkhttps://string-db.org/network/9606.ENSP00000393139Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3; Belongs [...]
FBXO15 protein networkhttps://string-db.org/network/9606.ENSP00000393154F-box only protein 15; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
TMEM151B protein networkhttps://string-db.org/network/9606.ENSP00000393161Transmembrane protein 151B; Belongs to the TMEM151 family.
DCAF1 protein networkhttps://string-db.org/network/9606.ENSP00000393183DDB1- and CUL4-associated factor 1; Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine- protein kinase, playing key roles [...]
HES4 protein networkhttps://string-db.org/network/9606.ENSP00000393198Transcription factor HES-4; Transcriptional repressor. Binds DNA on N-box motifs: 5'- CACNAG-3' (By similarity).
CFAP221 protein networkhttps://string-db.org/network/9606.ENSP00000393222Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis.
RPS18 protein networkhttps://string-db.org/network/9606.ENSP0000039324140S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
ZNF7 protein networkhttps://string-db.org/network/9606.ENSP00000393260Zinc finger protein 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NANOS1 protein networkhttps://string-db.org/network/9606.ENSP00000393275Nanos homolog 1; May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of inte [...]
FGFR1 protein networkhttps://string-db.org/network/9606.ENSP00000393312Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic developmen [...]
EPS15L1 protein networkhttps://string-db.org/network/9606.ENSP00000393313Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of i [...]
CT47A1 protein networkhttps://string-db.org/network/9606.ENSP00000393315Cancer/testis antigen family 47 member A1.
TMX1 protein networkhttps://string-db.org/network/9606.ENSP00000393316Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide [...]
EIF4E3 protein networkhttps://string-db.org/network/9606.ENSP00000393324Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhib [...]
TBXA2R protein networkhttps://string-db.org/network/9606.ENSP00000393333Thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G- protein that activates a phosphatidylin [...]
KIF5C protein networkhttps://string-db.org/network/9606.ENSP00000393379Kinesin heavy chain isoform 5C; Involved in synaptic transmission. Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may pl [...]
SNRPG protein networkhttps://string-db.org/network/9606.ENSP00000393388Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, [...]
MYO1A protein networkhttps://string-db.org/network/9606.ENSP00000393392Unconventional myosin-Ia; Involved in directing the movement of organelles along actin filaments; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
CASP14 protein networkhttps://string-db.org/network/9606.ENSP00000393417Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocy [...]
SMYD1 protein networkhttps://string-db.org/network/9606.ENSP00000393453Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for [...]
CD163L1 protein networkhttps://string-db.org/network/9606.ENSP00000393474Scavenger receptor cysteine-rich type 1 protein M160; CD163 molecule like 1.
ABLIM2 protein networkhttps://string-db.org/network/9606.ENSP00000393511Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
IFT27 protein networkhttps://string-db.org/network/9606.ENSP00000393541Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interactio [...]
SLC4A4 protein networkhttps://string-db.org/network/9606.ENSP00000393557Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux a [...]
PACS2 protein networkhttps://string-db.org/network/9606.ENSP00000393559Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria wi [...]
HLA-DPA1 protein networkhttps://string-db.org/network/9606.ENSP00000393566HLA class II histocompatibility antigen, DP alpha 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell sur [...]
BIRC6 protein networkhttps://string-db.org/network/9606.ENSP00000393596Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin [...]
ADM5 protein networkhttps://string-db.org/network/9606.ENSP00000393631Putative adrenomedullin-5-like protein; Probable non-functional remnant of adrenomedullin-5. Belongs to the adrenomedullin family.
FAM126B protein networkhttps://string-db.org/network/9606.ENSP00000393667Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Belongs to the FAM126 family.
MIGA1 protein networkhttps://string-db.org/network/9606.ENSP00000393675Mitoguardin 1; Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regu [...]
CLEC17A protein networkhttps://string-db.org/network/9606.ENSP00000393719C-type lectin domain family 17, member A; Cell surface receptor which may be involved in carbohydrate- mediated communication between cells in the germinal center. Binds glycans with terminal alp [...]
SESN1 protein networkhttps://string-db.org/network/9606.ENSP00000393762Sestrin-1; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 a [...]
FCHO2 protein networkhttps://string-db.org/network/9606.ENSP00000393776F-BAR domain only protein 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formati [...]
NKIRAS1 protein networkhttps://string-db.org/network/9606.ENSP00000393785NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (N [...]
PPP1R3G protein networkhttps://string-db.org/network/9606.ENSP00000393832Protein phosphatase 1 regulatory subunit 3G; Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feed [...]
ZNF506 protein networkhttps://string-db.org/network/9606.ENSP00000393835Zinc finger protein 506; May be involved in transcriptional regulation.
BLOC1S3 protein networkhttps://string-db.org/network/9606.ENSP00000393840Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
PPIAL4G protein networkhttps://string-db.org/network/9606.ENSP00000393845Peptidyl-prolyl cis-trans isomerase A-like 4G; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...]
PLA2G10 protein networkhttps://string-db.org/network/9606.ENSP00000393847Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell [...]
CENPBD1 protein networkhttps://string-db.org/network/9606.ENSP00000393854CENPB DNA-binding domain containing 1.
ZNF655 protein networkhttps://string-db.org/network/9606.ENSP00000393876Zinc finger protein 655; May be involved in transcriptional regulation.
OR5K2 protein networkhttps://string-db.org/network/9606.ENSP00000393889Olfactory receptor 5K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RUSC2 protein networkhttps://string-db.org/network/9606.ENSP00000393922Iporin; RUN and SH3 domain containing 2.
TTC39A protein networkhttps://string-db.org/network/9606.ENSP00000393952Tetratricopeptide repeat domain 39A.
KIFC1 protein networkhttps://string-db.org/network/9606.ENSP00000393963Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles (By similarity). Regulate [...]
PRKD2 protein networkhttps://string-db.org/network/9606.ENSP00000393978Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in [...]
TAFA2 protein networkhttps://string-db.org/network/9606.ENSP00000393987Chemokine-like protein TAFA-2; Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions; Belongs to the TAFA family.
KCNK2 protein networkhttps://string-db.org/network/9606.ENSP00000394033Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a v [...]
SLA protein networkhttps://string-db.org/network/9606.ENSP00000394049Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved [...]
NOSTRIN protein networkhttps://string-db.org/network/9606.ENSP00000394051Nostrin; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.
GDI1 protein networkhttps://string-db.org/network/9606.ENSP00000394071Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Prom [...]
LRRC74B protein networkhttps://string-db.org/network/9606.ENSP00000394078Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B.
JMJD6 protein networkhttps://string-db.org/network/9606.ENSP00000394085Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydrox [...]
H7C0C1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000394107Uncharacterized protein.
DAP protein networkhttps://string-db.org/network/9606.ENSP00000394163Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
SLCO1B7 protein networkhttps://string-db.org/network/9606.ENSP00000394168Solute carrier organic anion transporter family member 1B7.
TMEM182 protein networkhttps://string-db.org/network/9606.ENSP00000394178Transmembrane protein 182.
CDKN2AIPNL protein networkhttps://string-db.org/network/9606.ENSP00000394183CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like.
CSF2RA protein networkhttps://string-db.org/network/9606.ENSP00000394227Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proli [...]
ZNF716 protein networkhttps://string-db.org/network/9606.ENSP00000394248Zinc finger protein 716; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
OR4F3 protein networkhttps://string-db.org/network/9606.ENSP00000394282Olfactory receptor family 4 subfamily F member 3.
BZW1 protein networkhttps://string-db.org/network/9606.ENSP00000394316Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly.
COMMD5 protein networkhttps://string-db.org/network/9606.ENSP00000394331COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase tra [...]
DIXDC1 protein networkhttps://string-db.org/network/9606.ENSP00000394352Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
ZNF625 protein networkhttps://string-db.org/network/9606.ENSP00000394380Zinc finger protein 625; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
KCTD15 protein networkhttps://string-db.org/network/9606.ENSP00000394390BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activ [...]
ANAPC7 protein networkhttps://string-db.org/network/9606.ENSP00000394394Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...]
MORF4L2 protein networkhttps://string-db.org/network/9606.ENSP00000394417Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosoma [...]
BTBD18 protein networkhttps://string-db.org/network/9606.ENSP00000394472BTB/POZ domain-containing protein 18; Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable e [...]
DCLK3 protein networkhttps://string-db.org/network/9606.ENSP00000394484Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3.
CORO1C protein networkhttps://string-db.org/network/9606.ENSP00000394496Coronin-1C; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. [...]
PRR12 protein networkhttps://string-db.org/network/9606.ENSP00000394510Proline-rich protein 12; Proline rich 12.
NHSL1 protein networkhttps://string-db.org/network/9606.ENSP00000394546NHS-like protein 1; NHS like 1; Belongs to the NHS family.
MAPK9 protein networkhttps://string-db.org/network/9606.ENSP00000394560Mitogen-activated protein kinase 9; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. [...]
NUTM2B protein networkhttps://string-db.org/network/9606.ENSP00000394623NUT family member 2B.
OPRM1 protein networkhttps://string-db.org/network/9606.ENSP00000394624Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, [...]
IQCF5 protein networkhttps://string-db.org/network/9606.ENSP00000394653IQ motif containing F5.
SEMA4B protein networkhttps://string-db.org/network/9606.ENSP00000394720Semaphorin-4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
CLK1 protein networkhttps://string-db.org/network/9606.ENSP00000394734Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the sp [...]
IPCEF1 protein networkhttps://string-db.org/network/9606.ENSP00000394751Interaction protein for cytohesin exchange factors 1.
ZNF516 protein networkhttps://string-db.org/network/9606.ENSP00000394757Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose ti [...]
CMYA5 protein networkhttps://string-db.org/network/9606.ENSP00000394770Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May functio [...]
SENP1 protein networkhttps://string-db.org/network/9606.ENSP00000394791Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ub [...]
PTPN13 protein networkhttps://string-db.org/network/9606.ENSP00000394794Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3 [...]
GCA protein networkhttps://string-db.org/network/9606.ENSP00000394842Grancalcin; Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.
DOCK8 protein networkhttps://string-db.org/network/9606.ENSP00000394888Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, require [...]
ORM2 protein networkhttps://string-db.org/network/9606.ENSP00000394936Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influe [...]
GSG1L protein networkhttps://string-db.org/network/9606.ENSP00000394954Germ cell-specific gene 1-like protein; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating.
KLHL24 protein networkhttps://string-db.org/network/9606.ENSP00000395012Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubi [...]
TRIM51 protein networkhttps://string-db.org/network/9606.ENSP00000395086Tripartite motif-containing 51.
TMEM68 protein networkhttps://string-db.org/network/9606.ENSP00000395204Transmembrane protein 68.
IGFL2 protein networkhttps://string-db.org/network/9606.ENSP00000395219Insulin growth factor-like family member 2; Potential ligand of the IGFLR1 cell membrane receptor.
SYTL5 protein networkhttps://string-db.org/network/9606.ENSP00000395220Synaptotagmin-like protein 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
MTFR2 protein networkhttps://string-db.org/network/9606.ENSP00000395232Mitochondrial fission regulator 2; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).
TMEM229A protein networkhttps://string-db.org/network/9606.ENSP00000395244Transmembrane protein 229A.
RETREG2 protein networkhttps://string-db.org/network/9606.ENSP00000395249Reticulophagy regulator family member 2; Belongs to the RETREG family.
ZBED9 protein networkhttps://string-db.org/network/9606.ENSP00000395259SCAN domain-containing protein 3; Zinc finger BED-type containing 9.
C9orf116 protein networkhttps://string-db.org/network/9606.ENSP00000395281UPF0691 protein C9orf116; Chromosome 9 open reading frame 116.
CD70 protein networkhttps://string-db.org/network/9606.ENSP00000395294CD70 antigen; Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. [...]
FAM185A protein networkhttps://string-db.org/network/9606.ENSP00000395340Protein FAM185A; Family with sequence similarity 185 member A.
BTBD19 protein networkhttps://string-db.org/network/9606.ENSP00000395461BTB/POZ domain-containing protein 19; BTB domain containing 19.
MAN2B1 protein networkhttps://string-db.org/network/9606.ENSP00000395473Lysosomal alpha-mannosidase A peptide; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs [...]
SNX10 protein networkhttps://string-db.org/network/9606.ENSP00000395474Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transpor [...]
PATE3 protein networkhttps://string-db.org/network/9606.ENSP00000395505Prostate and testis expressed 3; Belongs to the PATE family.
MECP2 protein networkhttps://string-db.org/network/9606.ENSP00000395535Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. M [...]
TNRC18 protein networkhttps://string-db.org/network/9606.ENSP00000395538Trinucleotide repeat-containing gene 18 protein; Trinucleotide repeat containing 18.
ELOA protein networkhttps://string-db.org/network/9606.ENSP00000395574Elongin-A; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...]
CTAGE9 protein networkhttps://string-db.org/network/9606.ENSP00000395587CTAGE family member 9.
IFI35 protein networkhttps://string-db.org/network/9606.ENSP00000395590Interferon-induced 35 kDa protein; Not yet known; Belongs to the NMI family.
CXCR6 protein networkhttps://string-db.org/network/9606.ENSP00000395704C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
RAPGEF3 protein networkhttps://string-db.org/network/9606.ENSP00000395708Rap guanine nucleotide exchange factor 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RA [...]
ZNF200 protein networkhttps://string-db.org/network/9606.ENSP00000395723Zinc finger protein 200; Could have a role in spermatogenesis.
ZNF737 protein networkhttps://string-db.org/network/9606.ENSP00000395733Zinc finger protein 737; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TRMT2A protein networkhttps://string-db.org/network/9606.ENSP00000395738tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methy [...]
GNL3 protein networkhttps://string-db.org/network/9606.ENSP00000395772Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradatio [...]
WDR20 protein networkhttps://string-db.org/network/9606.ENSP00000395793WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop o [...]
ITPRID1 protein networkhttps://string-db.org/network/9606.ENSP00000395835Protein ITPRID1; ITPR interacting domain containing 1.
NSD1 protein networkhttps://string-db.org/network/9606.ENSP00000395929Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negativ [...]
SLC12A4 protein networkhttps://string-db.org/network/9606.ENSP00000395983Solute carrier family 12 member 4; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involv [...]
PLA2G4B protein networkhttps://string-db.org/network/9606.ENSP00000396045Cytosolic phospholipase A2 beta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a m [...]
BRMS1 protein networkhttps://string-db.org/network/9606.ENSP00000396052Breast cancer metastasis-suppressor 1; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding [...]
UBR3 protein networkhttps://string-db.org/network/9606.ENSP00000396068E3 ubiquitin-protein ligase UBR3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that a [...]
OR6V1 protein networkhttps://string-db.org/network/9606.ENSP00000396085Olfactory receptor 6V1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FBRSL1 protein networkhttps://string-db.org/network/9606.ENSP00000396160Fibrosin-1-like protein; Fibrosin like 1; Belongs to the AUTS2 family.
CLEC2A protein networkhttps://string-db.org/network/9606.ENSP00000396163C-type lectin domain family 2 member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced e [...]
FGF13 protein networkhttps://string-db.org/network/9606.ENSP00000396198Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action [...]
DELE1 protein networkhttps://string-db.org/network/9606.ENSP00000396225DAP3-binding cell death enhancer 1; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.
DEPDC4 protein networkhttps://string-db.org/network/9606.ENSP00000396234DEP domain containing 4.
IK protein networkhttps://string-db.org/network/9606.ENSP00000396301Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA [...]
CLDN25 protein networkhttps://string-db.org/network/9606.ENSP00000396304Putative claudin-25; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
DHFR protein networkhttps://string-db.org/network/9606.ENSP00000396308Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine [...]
SCN4A protein networkhttps://string-db.org/network/9606.ENSP00000396320Sodium channel protein type 4 subunit alpha; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Altern [...]
HLA-DQB2 protein networkhttps://string-db.org/network/9606.ENSP00000396330HLA class II histocompatibility antigen, DQ beta 2 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...]
CHD9 protein networkhttps://string-db.org/network/9606.ENSP00000396345Chromodomain-helicase-DNA-binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has [...]
ZNF302 protein networkhttps://string-db.org/network/9606.ENSP00000396379Zinc finger protein 302.
GPATCH4 protein networkhttps://string-db.org/network/9606.ENSP00000396441G-patch domain containing 4.
OSGIN2 protein networkhttps://string-db.org/network/9606.ENSP00000396445Oxidative stress-induced growth inhibitor 2; May be involved in meiosis or the maturation of germ cells.
PUDP protein networkhttps://string-db.org/network/9606.ENSP00000396452Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hy [...]
MAPKAPK3 protein networkhttps://string-db.org/network/9606.ENSP00000396467MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional reg [...]
SLC35G6 protein networkhttps://string-db.org/network/9606.ENSP00000396523Solute carrier family 35 member G6.
H7C0S8_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000396527RPOL4c domain-containing protein.
DYTN protein networkhttps://string-db.org/network/9606.ENSP00000396593Dystrotelin.
GLB1L3 protein networkhttps://string-db.org/network/9606.ENSP00000396615Beta-galactosidase-1-like protein 3; Galactosidase beta 1 like 3.
MROH7 protein networkhttps://string-db.org/network/9606.ENSP00000396622Maestro heat like repeat family member 7.
TEX264 protein networkhttps://string-db.org/network/9606.ENSP00000396628Testis-expressed protein 264; Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic retic [...]
PRR23C protein networkhttps://string-db.org/network/9606.ENSP00000396648Proline-rich protein 23C; Proline rich 23C; Belongs to the PRR23 family.
FTSJ3 protein networkhttps://string-db.org/network/9606.ENSP00000396673pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.
C4A protein networkhttps://string-db.org/network/9606.ENSP00000396688Complement C4-A alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and i [...]
NTM protein networkhttps://string-db.org/network/9606.ENSP00000396722Neurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family.
ANKRD60 protein networkhttps://string-db.org/network/9606.ENSP00000396747Ankyrin repeat domain 60.
KANSL3 protein networkhttps://string-db.org/network/9606.ENSP00000396749KAT8 regulatory NSL complex subunit 3; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...]
CNTD2 protein networkhttps://string-db.org/network/9606.ENSP00000396755Cyclin N-terminal domain-containing protein 2.
NFIC protein networkhttps://string-db.org/network/9606.ENSP00000396843Nuclear factor 1 C-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...]
ZNF697 protein networkhttps://string-db.org/network/9606.ENSP00000396857Zinc finger protein 697; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SCN1B protein networkhttps://string-db.org/network/9606.ENSP00000396915Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances [...]
URGCP protein networkhttps://string-db.org/network/9606.ENSP00000396918Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) [...]
RUBCNL protein networkhttps://string-db.org/network/9606.ENSP00000396935Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) [...]
PRR29 protein networkhttps://string-db.org/network/9606.ENSP00000396936Proline-rich protein 29; Proline rich 29.
PSMD13 protein networkhttps://string-db.org/network/9606.ENSP0000039693726S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...]
ATF5 protein networkhttps://string-db.org/network/9606.ENSP00000396954Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP resp [...]
BAHD1 protein networkhttps://string-db.org/network/9606.ENSP00000396976Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. [...]
TENT4B protein networkhttps://string-db.org/network/9606.ENSP00000396995Terminal nucleotidyltransferase 4B; Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail lead [...]
TEX22 protein networkhttps://string-db.org/network/9606.ENSP00000397002Testis-expressed protein 22; Testis expressed 22.
GRIK2 protein networkhttps://string-db.org/network/9606.ENSP00000397026Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitato [...]
SMIM34A protein networkhttps://string-db.org/network/9606.ENSP00000397039Small integral membrane protein 34A.
PPM1N protein networkhttps://string-db.org/network/9606.ENSP00000397050Protein phosphatase, Mg2+/Mn2+ dependent 1N; Belongs to the PP2C family.
TRIM10 protein networkhttps://string-db.org/network/9606.ENSP00000397073Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis. Belongs to the TRIM/RBCC family.
SFTPA1 protein networkhttps://string-db.org/network/9606.ENSP00000397082Pulmonary surfactant-associated protein A1; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alve [...]
GAGE12C protein networkhttps://string-db.org/network/9606.ENSP00000397103G antigen 12C.
PRKAG3 protein networkhttps://string-db.org/network/9606.ENSP000003971335'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...]
TSPY10 protein networkhttps://string-db.org/network/9606.ENSP00000397151Testis specific protein Y-linked 10; Belongs to the nucleosome assembly protein (NAP) family.
PERP protein networkhttps://string-db.org/network/9606.ENSP00000397157P53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. P [...]
BLCAP protein networkhttps://string-db.org/network/9606.ENSP00000397172Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
ZNF300 protein networkhttps://string-db.org/network/9606.ENSP00000397178Zinc finger protein 300; Has a transcriptional repressor activity.
RGS4 protein networkhttps://string-db.org/network/9606.ENSP00000397181Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on [...]
FAM104B protein networkhttps://string-db.org/network/9606.ENSP00000397188Protein FAM104B; Family with sequence similarity 104 member B.
KDM4E protein networkhttps://string-db.org/network/9606.ENSP00000397239Lysine-specific demethylase 4E; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
BZW2 protein networkhttps://string-db.org/network/9606.ENSP00000397249Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation.
ATXN7L3 protein networkhttps://string-db.org/network/9606.ENSP00000397259Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediatin [...]
SELENBP1 protein networkhttps://string-db.org/network/9606.ENSP00000397261Methanethiol oxidase; Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved [...]
FAM136A protein networkhttps://string-db.org/network/9606.ENSP00000397269Protein FAM136A; Family with sequence similarity 136 member A.
NTF3 protein networkhttps://string-db.org/network/9606.ENSP00000397297Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.
LRRN3 protein networkhttps://string-db.org/network/9606.ENSP00000397312Leucine rich repeat neuronal 3.
GRID2IP protein networkhttps://string-db.org/network/9606.ENSP00000397351Delphilin; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
C19orf25 protein networkhttps://string-db.org/network/9606.ENSP00000397394UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family.
TSEN34 protein networkhttps://string-db.org/network/9606.ENSP00000397402tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the spl [...]
RLN3 protein networkhttps://string-db.org/network/9606.ENSP00000397415Relaxin-3 A chain; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family.
TSC22D1 protein networkhttps://string-db.org/network/9606.ENSP00000397435TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
COG6 protein networkhttps://string-db.org/network/9606.ENSP00000397441Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Belongs to the COG6 family.
DUSP22 protein networkhttps://string-db.org/network/9606.ENSP00000397459Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By simil [...]
ACTL6A protein networkhttps://string-db.org/network/9606.ENSP00000397552Actin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remode [...]
TENT2 protein networkhttps://string-db.org/network/9606.ENSP00000397563Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly [...]
GTF2IRD1 protein networkhttps://string-db.org/network/9606.ENSP00000397566General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I tr [...]
KY protein networkhttps://string-db.org/network/9606.ENSP00000397598Kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by [...]
ASB15 protein networkhttps://string-db.org/network/9606.ENSP00000397655Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
ALKBH8 protein networkhttps://string-db.org/network/9606.ENSP00000397673Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its me [...]
ENDOU protein networkhttps://string-db.org/network/9606.ENSP00000397679Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini.
ZNF28 protein networkhttps://string-db.org/network/9606.ENSP00000397693Zinc finger protein 28; May be involved in transcriptional regulation.
TMA7 protein networkhttps://string-db.org/network/9606.ENSP00000397843Translation machinery associated 7 homolog.
IL34 protein networkhttps://string-db.org/network/9606.ENSP00000397863Interleukin-34; Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an impor [...]
PET117 protein networkhttps://string-db.org/network/9606.ENSP00000397881Protein PET117 homolog, mitochondrial; PET117 cytochrome c oxidase chaperone.
MRO protein networkhttps://string-db.org/network/9606.ENSP00000397900Maestro.
LPIN1 protein networkhttps://string-db.org/network/9606.ENSP00000397908Phosphatidate phosphatase LPIN1; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catal [...]
SP140L protein networkhttps://string-db.org/network/9606.ENSP00000397911SP140 nuclear body protein like.
ATP2C2 protein networkhttps://string-db.org/network/9606.ENSP00000397925Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
POLDIP3 protein networkhttps://string-db.org/network/9606.ENSP00000397927Polymerase delta-interacting protein 3; Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA trans [...]
PLEKHA8 protein networkhttps://string-db.org/network/9606.ENSP00000397947Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) t [...]
CROCC2 protein networkhttps://string-db.org/network/9606.ENSP00000397968Ciliary rootlet coiled-coil, rootletin family member 2; Belongs to the rootletin family.
CLDN9 protein networkhttps://string-db.org/network/9606.ENSP00000398017Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
F8W6W0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000398035Uncharacterized protein.
HIGD1A protein networkhttps://string-db.org/network/9606.ENSP00000398064HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the [...]
ATP9B protein networkhttps://string-db.org/network/9606.ENSP00000398076Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B.
TMEM243 protein networkhttps://string-db.org/network/9606.ENSP00000398083Transmembrane protein 243; Belongs to the TMEM243 family.
ZNF821 protein networkhttps://string-db.org/network/9606.ENSP00000398089Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZBED5 protein networkhttps://string-db.org/network/9606.ENSP00000398106Zinc finger BED-type containing 5.
E2F5 protein networkhttps://string-db.org/network/9606.ENSP00000398124Transcription factor E2F5; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate [...]
GSPT1 protein networkhttps://string-db.org/network/9606.ENSP00000398131Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activ [...]
ALKBH2 protein networkhttps://string-db.org/network/9606.ENSP00000398181DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA contain [...]
TTC21A protein networkhttps://string-db.org/network/9606.ENSP00000398211Tetratricopeptide repeat protein 21A; Intraflagellar transport (IFT)-associated protein required for spermatogenesis. Required for sperm flagellar formation and intraflagellar transport. Belongs [...]
SOX5 protein networkhttps://string-db.org/network/9606.ENSP00000398273Transcription factor SOX-5; Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro.
PPP1R14D protein networkhttps://string-db.org/network/9606.ENSP00000398342Protein phosphatase 1 regulatory subunit 14D; Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1C [...]
C11orf68 protein networkhttps://string-db.org/network/9606.ENSP00000398350UPF0696 protein C11orf68; Chromosome 11 open reading frame 68.
LIFR protein networkhttps://string-db.org/network/9606.ENSP00000398368Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to recepto [...]
FAM133B protein networkhttps://string-db.org/network/9606.ENSP00000398401Protein FAM133B; Family with sequence similarity 133 member B.
KDM8 protein networkhttps://string-db.org/network/9606.ENSP00000398410Bifunctional peptidase and arginyl-hydroxylase JMJD5; Bifunctional enzyme that acts both as an endopeptidase and 2- oxoglutarate-dependent monoxygenase. Endopeptidase that cleaves histones N-term [...]
GOLGA8N protein networkhttps://string-db.org/network/9606.ENSP00000398454Golgin A8 family member N; Belongs to the GOLGA8 family.
CADPS2 protein networkhttps://string-db.org/network/9606.ENSP00000398481Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogen [...]
DIABLO-2 protein networkhttps://string-db.org/network/9606.ENSP00000398495Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins [...]
EEF2KMT protein networkhttps://string-db.org/network/9606.ENSP00000398502Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'.
CALCOCO2 protein networkhttps://string-db.org/network/9606.ENSP00000398523Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galecti [...]
ENSP00000398526 protein networkhttps://string-db.org/network/9606.ENSP00000398526Novel protein.
CT47A3 protein networkhttps://string-db.org/network/9606.ENSP00000398559Cancer/testis antigen family 47 member A3.
SPATA13 protein networkhttps://string-db.org/network/9606.ENSP00000398560Spermatogenesis-associated protein 13; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a [...]
PRF1 protein networkhttps://string-db.org/network/9606.ENSP00000398568Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recogniz [...]
TAMM41 protein networkhttps://string-db.org/network/9606.ENSP00000398596Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosyn [...]
EXOSC6 protein networkhttps://string-db.org/network/9606.ENSP00000398597Exosome complex component MTR3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...]
ANXA11 protein networkhttps://string-db.org/network/9606.ENSP00000398610Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
FAM71E2 protein networkhttps://string-db.org/network/9606.ENSP00000398617Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family.
KRTAP25-1 protein networkhttps://string-db.org/network/9606.ENSP00000398619Keratin-associated protein 25-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
GNG4 protein networkhttps://string-db.org/network/9606.ENSP00000398629Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...]
CD44 protein networkhttps://string-db.org/network/9606.ENSP00000398632CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Particip [...]
ARL13A protein networkhttps://string-db.org/network/9606.ENSP00000398637ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A.
ITK protein networkhttps://string-db.org/network/9606.ENSP00000398655Tyrosine-protein kinase ITK/TSK; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventiona [...]
VWA5B2 protein networkhttps://string-db.org/network/9606.ENSP00000398688Von Willebrand factor A domain containing 5B2.
TNF protein networkhttps://string-db.org/network/9606.ENSP00000398698Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is p [...]
CHID1 protein networkhttps://string-db.org/network/9606.ENSP00000398722Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length o [...]
C2orf74 protein networkhttps://string-db.org/network/9606.ENSP00000398725Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74.
CCN1 protein networkhttps://string-db.org/network/9606.ENSP00000398736CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a n [...]
RELL1 protein networkhttps://string-db.org/network/9606.ENSP00000398778RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed.
SNX13 protein networkhttps://string-db.org/network/9606.ENSP00000398789Sorting nexin-13; May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas.
ZNF142 protein networkhttps://string-db.org/network/9606.ENSP00000398798Zinc finger protein 142; May be involved in transcriptional regulation.
TSTA3 protein networkhttps://string-db.org/network/9606.ENSP00000398803GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
PHF21A protein networkhttps://string-db.org/network/9606.ENSP00000398824PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE s [...]
AGTR1 protein networkhttps://string-db.org/network/9606.ENSP00000398832Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.
KMT2B protein networkhttps://string-db.org/network/9606.ENSP00000398837Histone-lysine N-methyltransferase 2B; Histone methyltransferase that methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. [...]
CDK12 protein networkhttps://string-db.org/network/9606.ENSP00000398880Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transc [...]
DOHH protein networkhttps://string-db.org/network/9606.ENSP00000398882Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation [...]
HLA-DMB protein networkhttps://string-db.org/network/9606.ENSP00000398890HLA class II histocompatibility antigen, DM beta chain; Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II [...]
CNTNAP5 protein networkhttps://string-db.org/network/9606.ENSP00000399013Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellu [...]
SLC6A12 protein networkhttps://string-db.org/network/9606.ENSP00000399136Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic [...]
HLA-B protein networkhttps://string-db.org/network/9606.ENSP00000399168HLA class I histocompatibility antigen, B alpha chain; Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily vir [...]
DDX19B-2 protein networkhttps://string-db.org/network/9606.ENSP00000399208ATP-dependent RNA helicase DDX19B; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein pa [...]
MXRA8 protein networkhttps://string-db.org/network/9606.ENSP00000399229Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-c [...]
FCHSD1 protein networkhttps://string-db.org/network/9606.ENSP00000399259F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL.
FGF16 protein networkhttps://string-db.org/network/9606.ENSP00000399324Fibroblast growth factor 16; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferatio [...]
CT62 protein networkhttps://string-db.org/network/9606.ENSP00000399356Cancer/testis associated 62.
PRNP protein networkhttps://string-db.org/network/9606.ENSP00000399376Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May pr [...]
C3orf52 protein networkhttps://string-db.org/network/9606.ENSP00000399392TPA-induced transmembrane protein; Chromosome 3 open reading frame 52.
KLC2 protein networkhttps://string-db.org/network/9606.ENSP00000399403Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...]
KYAT1 protein networkhttps://string-db.org/network/9606.ENSP00000399415Kynurenine--oxoglutarate transaminase 1; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of [...]
LRRC70 protein networkhttps://string-db.org/network/9606.ENSP00000399441Leucine-rich repeat-containing protein 70; Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS).
DDOST protein networkhttps://string-db.org/network/9606.ENSP00000399457Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose o [...]
ATF7 protein networkhttps://string-db.org/network/9606.ENSP00000399465Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in [...]
JMJD8 protein networkhttps://string-db.org/network/9606.ENSP00000399475JmjC domain-containing protein 8; Functions as a positive regulator of TNF-induced NF-kappa-B signaling. Regulates angiogenesis and cellular metabolism through interaction with PKM.
LY6H protein networkhttps://string-db.org/network/9606.ENSP00000399485Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role [...]
TNIK protein networkhttps://string-db.org/network/9606.ENSP00000399511TRAF2 and NCK-interacting protein kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to acti [...]
SATB1 protein networkhttps://string-db.org/network/9606.ENSP00000399518DNA-binding protein SATB1; Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds t [...]
ANKRD63 protein networkhttps://string-db.org/network/9606.ENSP00000399547Ankyrin repeat domain 63.
MRS2 protein networkhttps://string-db.org/network/9606.ENSP00000399585Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial r [...]
GAB3 protein networkhttps://string-db.org/network/9606.ENSP00000399588GRB2 associated binding protein 3.
PRG4 protein networkhttps://string-db.org/network/9606.ENSP00000399679Proteoglycan 4 C-terminal part; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent s [...]
PLAC8 protein networkhttps://string-db.org/network/9606.ENSP00000399700Placenta-specific gene 8 protein; Placenta associated 8.
BEST1 protein networkhttps://string-db.org/network/9606.ENSP00000399709Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.
CT47A6 protein networkhttps://string-db.org/network/9606.ENSP00000399711Cancer/testis antigen family 47 member A6.
MBIP protein networkhttps://string-db.org/network/9606.ENSP00000399718MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activ [...]
CHRM2 protein networkhttps://string-db.org/network/9606.ENSP00000399745Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...]
LRCH3 protein networkhttps://string-db.org/network/9606.ENSP00000399751DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.
MOV10 protein networkhttps://string-db.org/network/9606.ENSP00000399797Helicase MOV-10; 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silenc [...]
CRYZ protein networkhttps://string-db.org/network/9606.ENSP00000399805Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequ [...]
HOXC4 protein networkhttps://string-db.org/network/9606.ENSP00000399808Homeobox protein Hox-C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
POLG protein networkhttps://string-db.org/network/9606.ENSP00000399851DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA; Belongs to the DNA polymerase type-A family.
CNOT10 protein networkhttps://string-db.org/network/9606.ENSP00000399862CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA d [...]
ZNF839 protein networkhttps://string-db.org/network/9606.ENSP00000399863Zinc finger protein 839.
HMGA1 protein networkhttps://string-db.org/network/9606.ENSP00000399888High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleoso [...]
NBEAL1 protein networkhttps://string-db.org/network/9606.ENSP00000399903Neurobeachin-like protein 1; Neurobeachin like 1; Belongs to the WD repeat neurobeachin family.
NCOA2 protein networkhttps://string-db.org/network/9606.ENSP00000399968Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal doma [...]
PPP2R2D protein networkhttps://string-db.org/network/9606.ENSP00000399970Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis [...]
SLC52A1 protein networkhttps://string-db.org/network/9606.ENSP00000399979Solute carrier family 52, riboflavin transporter, member 1; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemic [...]
TAF6 protein networkhttps://string-db.org/network/9606.ENSP00000399982Transcription initiation factor TFIID subunit 6; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is mu [...]
PTPRJ protein networkhttps://string-db.org/network/9606.ENSP00000400010Receptor-type tyrosine-protein phosphatase eta; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SR [...]
KRTAP5-2 protein networkhttps://string-db.org/network/9606.ENSP00000400041Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
CT47A8 protein networkhttps://string-db.org/network/9606.ENSP00000400046Cancer/testis antigen family 47 member A8.
ASRGL1 protein networkhttps://string-db.org/network/9606.ENSP00000400057Isoaspartyl peptidase/L-asparaginase alpha chain; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory ne [...]
RIPOR1 protein networkhttps://string-db.org/network/9606.ENSP00000400099Rho family-interacting cell polarization regulator 1; Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter prote [...]
SLC25A13 protein networkhttps://string-db.org/network/9606.ENSP00000400101Calcium-binding mitochondrial carrier protein Aralar2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartat [...]
ZDHHC13 protein networkhttps://string-db.org/network/9606.ENSP00000400113Palmitoyltransferase ZDHHC13; Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
EWSR1 protein networkhttps://string-db.org/network/9606.ENSP00000400142RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS- fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimick [...]
B3GNT9 protein networkhttps://string-db.org/network/9606.ENSP00000400157UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9.
ATP5MF-PTCD1 protein networkhttps://string-db.org/network/9606.ENSP00000400168ATP5MF-PTCD1 readthrough.
RHOA protein networkhttps://string-db.org/network/9606.ENSP00000400175Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a vari [...]
NDUFAF8 protein networkhttps://string-db.org/network/9606.ENSP00000400184NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize N [...]
FJX1 protein networkhttps://string-db.org/network/9606.ENSP00000400223Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family.
TBATA protein networkhttps://string-db.org/network/9606.ENSP00000400224Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function.
DNAI2 protein networkhttps://string-db.org/network/9606.ENSP00000400252Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.
ULK3 protein networkhttps://string-db.org/network/9606.ENSP00000400312Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in th [...]
SLC2A11-2 protein networkhttps://string-db.org/network/9606.ENSP00000400325MFS domain-containing protein.
SNX27 protein networkhttps://string-db.org/network/9606.ENSP00000400333Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following intern [...]
FOXA2 protein networkhttps://string-db.org/network/9606.ENSP00000400341Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentia [...]
LAMA2 protein networkhttps://string-db.org/network/9606.ENSP00000400365Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...]
ERAP2 protein networkhttps://string-db.org/network/9606.ENSP00000400376Endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is [...]
ZNF146 protein networkhttps://string-db.org/network/9606.ENSP00000400391Zinc finger protein 146; Belongs to the krueppel C2H2-type zinc-finger protein family.
HNRNPF protein networkhttps://string-db.org/network/9606.ENSP00000400433Heterogeneous nuclear ribonucleoprotein F, N-terminally processed; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events [...]
SNAP91 protein networkhttps://string-db.org/network/9606.ENSP00000400459Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to i [...]
TMEM106C protein networkhttps://string-db.org/network/9606.ENSP00000400471Transmembrane protein 106C.
CMTM3 protein networkhttps://string-db.org/network/9606.ENSP00000400482CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family.
THAP5 protein networkhttps://string-db.org/network/9606.ENSP00000400500THAP domain-containing protein 5; Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in hu [...]
FASTKD1 protein networkhttps://string-db.org/network/9606.ENSP00000400513FAST kinase domain-containing protein 1, mitochondrial; Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity.
CCL24 protein networkhttps://string-db.org/network/9606.ENSP00000400533C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppre [...]
SNRPE protein networkhttps://string-db.org/network/9606.ENSP00000400591Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, [...]
PNPT1 protein networkhttps://string-db.org/network/9606.ENSP00000400646Polyribonucleotide nucleotidyltransferase 1, mitochondrial; RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides [...]
IQCD protein networkhttps://string-db.org/network/9606.ENSP00000400669Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the di [...]
GNA13 protein networkhttps://string-db.org/network/9606.ENSP00000400717Guanine nucleotide-binding protein subunit alpha-13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activat [...]
SLC35G2 protein networkhttps://string-db.org/network/9606.ENSP00000400839Solute carrier family 35 member G2; May play a role in cell proliferation.
ZNF736 protein networkhttps://string-db.org/network/9606.ENSP00000400852Zinc finger protein 736; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
AARSD1 protein networkhttps://string-db.org/network/9606.ENSP00000400870Alanyl-tRNA editing protein Aarsd1; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala).
ZNF234 protein networkhttps://string-db.org/network/9606.ENSP00000400878Zinc finger protein 234; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
USP17L11 protein networkhttps://string-db.org/network/9606.ENSP00000400880Ubiquitin carboxyl-terminal hydrolase 17-like protein 11; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
CAPNS2 protein networkhttps://string-db.org/network/9606.ENSP00000400882Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small s [...]
PPIP5K1 protein networkhttps://string-db.org/network/9606.ENSP00000400887Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphos [...]
TESPA1 protein networkhttps://string-db.org/network/9606.ENSP00000400892Protein TESPA1; Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen r [...]
PENK protein networkhttps://string-db.org/network/9606.ENSP00000400894Met-enkephalin-Arg-Gly-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and respo [...]
UBE2L3 protein networkhttps://string-db.org/network/9606.ENSP00000400906Ubiquitin conjugating enzyme E2 L3.
MYBPC1 protein networkhttps://string-db.org/network/9606.ENSP00000400908Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin fil [...]
SLAIN1 protein networkhttps://string-db.org/network/9606.ENSP00000400921SLAIN motif-containing protein 1; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elon [...]
SLC35G1 protein networkhttps://string-db.org/network/9606.ENSP00000400932Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing ca [...]
ZNF780A protein networkhttps://string-db.org/network/9606.ENSP00000400997Zinc finger protein 780A; May be involved in transcriptional regulation.
CAPZB protein networkhttps://string-db.org/network/9606.ENSP00000401010F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subuni [...]
GINS3 protein networkhttps://string-db.org/network/9606.ENSP00000401018DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind pref [...]
HECTD2 protein networkhttps://string-db.org/network/9606.ENSP00000401023Probable E3 ubiquitin-protein ligase HECTD2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly tran [...]
BARGIN protein networkhttps://string-db.org/network/9606.ENSP00000401076Bargin; GTPase activating protein (GAP) which specifically converts GTP-bound RAC1 and CDC42 in their inactive GDP-bound form. The GAP activity is enhanced by the non-covalent binding of K-29 and [...]
ANKRD34C protein networkhttps://string-db.org/network/9606.ENSP00000401089Ankyrin repeat domain 34C; Belongs to the ANKRD34 family.
SATB2 protein networkhttps://string-db.org/network/9606.ENSP00000401112DNA-binding protein SATB2; Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double- stranded DNA. Transcription factor contro [...]
SS18L2 protein networkhttps://string-db.org/network/9606.ENSP00000401115SS18-like protein 2; SS18 like 2.
GAS2 protein networkhttps://string-db.org/network/9606.ENSP00000401145Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements o [...]
BUD23 protein networkhttps://string-db.org/network/9606.ENSP00000401191Probable 18S rRNA (guanine-N(7))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methy [...]
USP19 protein networkhttps://string-db.org/network/9606.ENSP00000401197Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn [...]
NAA60 protein networkhttps://string-db.org/network/9606.ENSP00000401237N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini fac [...]
CTPS2 protein networkhttps://string-db.org/network/9606.ENSP00000401264CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine [...]
CBLL1 protein networkhttps://string-db.org/network/9606.ENSP00000401277E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targe [...]
SHC1 protein networkhttps://string-db.org/network/9606.ENSP00000401303SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. I [...]
FSIP2 protein networkhttps://string-db.org/network/9606.ENSP00000401306Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis.
FRG2B protein networkhttps://string-db.org/network/9606.ENSP00000401310Protein FRG2-like-1; FSHD region gene 2 family member B.
PRSS48 protein networkhttps://string-db.org/network/9606.ENSP00000401328Serine protease 48; Belongs to the peptidase S1 family.
C16orf90 protein networkhttps://string-db.org/network/9606.ENSP00000401335Uncharacterized protein C16orf90; Chromosome 16 open reading frame 90.
PGAP6 protein networkhttps://string-db.org/network/9606.ENSP00000401338Post-GPI attachment to proteins factor 6; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 [...]
TIA1 protein networkhttps://string-db.org/network/9606.ENSP00000401371Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). [...]
VPS53 protein networkhttps://string-db.org/network/9606.ENSP00000401435Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...]
LDB3 protein networkhttps://string-db.org/network/9606.ENSP00000401437LIM domain-binding protein 3; May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
ERN1 protein networkhttps://string-db.org/network/9606.ENSP00000401445Serine/threonine-protein kinase/endoribonuclease IRE1; Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) [...]
RANGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000401470Ran GTPase-activating protein 1; GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociatio [...]
TMEM232 protein networkhttps://string-db.org/network/9606.ENSP00000401477Transmembrane protein 232.
C11orf94 protein networkhttps://string-db.org/network/9606.ENSP00000401498Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94.
SIGLEC6 protein networkhttps://string-db.org/network/9606.ENSP00000401502Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may [...]
NAPRT protein networkhttps://string-db.org/network/9606.ENSP00000401508Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and [...]
STRC protein networkhttps://string-db.org/network/9606.ENSP00000401513Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family.
DNAH1 protein networkhttps://string-db.org/network/9606.ENSP00000401514Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the for [...]
RFX8 protein networkhttps://string-db.org/network/9606.ENSP00000401536DNA-binding protein RFX8; May be a transcription factor; Belongs to the RFX family.
RANBP1 protein networkhttps://string-db.org/network/9606.ENSP00000401564Ran-specific GTPase-activating protein; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation o [...]
ECD protein networkhttps://string-db.org/network/9606.ENSP00000401566Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2- mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcripti [...]
GPBP1 protein networkhttps://string-db.org/network/9606.ENSP00000401596Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family.
DTHD1 protein networkhttps://string-db.org/network/9606.ENSP00000401597Death domain containing 1.
MYO16 protein networkhttps://string-db.org/network/9606.ENSP00000401633Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...]
ZNF304 protein networkhttps://string-db.org/network/9606.ENSP00000401642Zinc finger protein 304; Acts as transcriptional regulator and plays a role in gene silencing. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation [...]
SERPINB2 protein networkhttps://string-db.org/network/9606.ENSP00000401645Plasminogen activator inhibitor 2; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1; Belongs to the serpin family. Ov- [...]
MYOCD protein networkhttps://string-db.org/network/9606.ENSP00000401678Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum respo [...]
GK protein networkhttps://string-db.org/network/9606.ENSP00000401720Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family.
P4HA3 protein networkhttps://string-db.org/network/9606.ENSP00000401749Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.
CITED1 protein networkhttps://string-db.org/network/9606.ENSP00000401764Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link betwee [...]
ATP5MPL protein networkhttps://string-db.org/network/9606.ENSP00000401770ATP synthase subunit ATP5MPL, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membran [...]
ACSF2 protein networkhttps://string-db.org/network/9606.ENSP00000401831Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-ch [...]
HYAL2 protein networkhttps://string-db.org/network/9606.ENSP00000401853Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displ [...]
MXD3 protein networkhttps://string-db.org/network/9606.ENSP00000401867Max dimerization protein 3; Transcriptional repressor. Binds with MAX to form a sequence- specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC [...]
KBTBD8 protein networkhttps://string-db.org/network/9606.ENSP00000401878Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(K [...]
RAF1 protein networkhttps://string-db.org/network/9606.ENSP00000401888RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this c [...]
BMPR1B protein networkhttps://string-db.org/network/9606.ENSP00000401907Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phospho [...]
PRSS45P protein networkhttps://string-db.org/network/9606.ENSP00000401932Serine protease 45, pseudogene.
TNRC6B protein networkhttps://string-db.org/network/9606.ENSP00000401946Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent transl [...]
ZNF223 protein networkhttps://string-db.org/network/9606.ENSP00000401947Zinc finger protein 223; May be involved in transcriptional regulation.
MAVS protein networkhttps://string-db.org/network/9606.ENSP00000401980Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced duri [...]
C17orf58 protein networkhttps://string-db.org/network/9606.ENSP00000402020UPF0450 protein C17orf58; Chromosome 17 open reading frame 58.
PDZD2 protein networkhttps://string-db.org/network/9606.ENSP00000402033Processed PDZ domain-containing protein 2; PDZ domain containing 2.
MTO1 protein networkhttps://string-db.org/network/9606.ENSP00000402038Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the MnmG family.
PVR protein networkhttps://string-db.org/network/9606.ENSP00000402060Poliovirus receptor; Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell cont [...]
WEE1 protein networkhttps://string-db.org/network/9606.ENSP00000402084Wee1-like protein kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onse [...]
SAMD3 protein networkhttps://string-db.org/network/9606.ENSP00000402092Sterile alpha motif domain containing 3.
L3MBTL1 protein networkhttps://string-db.org/network/9606.ENSP00000402107Lethal(3)malignant brain tumor-like protein 1; Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader [...]
SLC12A3 protein networkhttps://string-db.org/network/9606.ENSP00000402152Solute carrier family 12 member 3; Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption. Receptor for the pr [...]
IQCJ protein networkhttps://string-db.org/network/9606.ENSP00000402153IQ motif containing J.
MEF2B protein networkhttps://string-db.org/network/9606.ENSP00000402154Myocyte-specific enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription [...]
VSIG1 protein networkhttps://string-db.org/network/9606.ENSP00000402219V-set and immunoglobulin domain containing 1.
RUNX1T1 protein networkhttps://string-db.org/network/9606.ENSP00000402257Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...]
CDY2A protein networkhttps://string-db.org/network/9606.ENSP00000402280Testis-specific chromodomain protein Y 2; May have histone acetyltransferase activity.
LACTBL1 protein networkhttps://string-db.org/network/9606.ENSP00000402297Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family.
LAPTM4B protein networkhttps://string-db.org/network/9606.ENSP00000402301Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidy [...]
RPF2 protein networkhttps://string-db.org/network/9606.ENSP00000402338Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
COPG2 protein networkhttps://string-db.org/network/9606.ENSP00000402346Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosy [...]
CDRT15 protein networkhttps://string-db.org/network/9606.ENSP00000402355CMT1A duplicated region transcript 15.
TRIM48 protein networkhttps://string-db.org/network/9606.ENSP00000402414Tripartite motif containing 48; Belongs to the TRIM/RBCC family.
GRAMD1B protein networkhttps://string-db.org/network/9606.ENSP00000402457Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique doma [...]
CLSTN2 protein networkhttps://string-db.org/network/9606.ENSP00000402460Calsyntenin-2; May modulate calcium-mediated postsynaptic signals.
MTRR protein networkhttps://string-db.org/network/9606.ENSP00000402510Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary f [...]
SMG1 protein networkhttps://string-db.org/network/9606.ENSP00000402515Serine/threonine-protein kinase SMG1; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q [...]
SENP6 protein networkhttps://string-db.org/network/9606.ENSP00000402527Sentrin-specific protease 6; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process [...]
MTMR10 protein networkhttps://string-db.org/network/9606.ENSP00000402537Myotubularin related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.
PPFIA4 protein networkhttps://string-db.org/network/9606.ENSP00000402576Liprin-alpha-4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...]
MDGA1 protein networkhttps://string-db.org/network/9606.ENSP00000402584MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in t [...]
CPS1 protein networkhttps://string-db.org/network/9606.ENSP00000402608Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
H0Y626_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000402644Uncharacterized protein.
WDR83 protein networkhttps://string-db.org/network/9606.ENSP00000402653WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, lin [...]
TMEM177 protein networkhttps://string-db.org/network/9606.ENSP00000402661Transmembrane protein 177; Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT- [...]
BHMG1 protein networkhttps://string-db.org/network/9606.ENSP00000402674Basic helix-loop-helix and HMG box domain-containing protein 1.
PTH1R protein networkhttps://string-db.org/network/9606.ENSP00000402723Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G pro [...]
NR2C2AP protein networkhttps://string-db.org/network/9606.ENSP00000402756Nuclear receptor 2C2-associated protein; May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes; Belong [...]
PMEL protein networkhttps://string-db.org/network/9606.ENSP00000402758Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II m [...]
SLC22A5 protein networkhttps://string-db.org/network/9606.ENSP00000402760Solute carrier family 22 member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of c [...]
TMEM235 protein networkhttps://string-db.org/network/9606.ENSP00000402790Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family.
KCNK4 protein networkhttps://string-db.org/network/9606.ENSP00000402797Potassium channel subfamily K member 4; Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising [...]
IFRD2 protein networkhttps://string-db.org/network/9606.ENSP00000402849Interferon related developmental regulator 2.
TREML1 protein networkhttps://string-db.org/network/9606.ENSP00000402855Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response.
PLCL1 protein networkhttps://string-db.org/network/9606.ENSP00000402861Inactive phospholipase C-like protein 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatid [...]
TBC1D5 protein networkhttps://string-db.org/network/9606.ENSP00000402935TBC1 domain family member 5; May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal [...]
CCNQ protein networkhttps://string-db.org/network/9606.ENSP00000402949Cyclin-Q; Activating cyclin for the cyclin-associated kinase CDK10. Belongs to the cyclin family. Cyclin-like FAM58 subfamily.
HP1BP3 protein networkhttps://string-db.org/network/9606.ENSP00000403039Heterochromatin protein 1-binding protein 3; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically inf [...]
PHTF2 protein networkhttps://string-db.org/network/9606.ENSP00000403042Putative homeodomain transcription factor 2; May play a role in transcription regulation.
FRMD5 protein networkhttps://string-db.org/network/9606.ENSP00000403067FERM domain-containing protein 5; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail intera [...]
VKORC1L1 protein networkhttps://string-db.org/network/9606.ENSP00000403077Vitamin K epoxide reductase complex subunit 1-like protein 1; Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vit [...]
SIGIRR protein networkhttps://string-db.org/network/9606.ENSP00000403104Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the [...]
TMEM233 protein networkhttps://string-db.org/network/9606.ENSP00000403130Transmembrane protein 233.
C10orf105 protein networkhttps://string-db.org/network/9606.ENSP00000403151Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105.
RPL6 protein networkhttps://string-db.org/network/9606.ENSP0000040317260S ribosomal protein L6; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL6 family.
MAP10 protein networkhttps://string-db.org/network/9606.ENSP00000403208Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization o [...]
EMC9 protein networkhttps://string-db.org/network/9606.ENSP00000403210ER membrane protein complex subunit 9.
BHLHB9 protein networkhttps://string-db.org/network/9606.ENSP00000403226Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family.
FBXO43 protein networkhttps://string-db.org/network/9606.ENSP00000403293F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyc [...]
ANKRD36C protein networkhttps://string-db.org/network/9606.ENSP00000403302Ankyrin repeat domain 36C.
TSPY1 protein networkhttps://string-db.org/network/9606.ENSP00000403304Testis-specific Y-encoded protein 1; May be involved in sperm differentiation and proliferation.
SNRNP35 protein networkhttps://string-db.org/network/9606.ENSP00000403310Small nuclear ribonucleoprotein U11/U12 subunit 35.
ARHGAP27 protein networkhttps://string-db.org/network/9606.ENSP00000403323Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an ina [...]
AAMP protein networkhttps://string-db.org/network/9606.ENSP00000403343Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.
AP2M1 protein networkhttps://string-db.org/network/9606.ENSP00000403362AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. [...]
FAM126A protein networkhttps://string-db.org/network/9606.ENSP00000403396Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) s [...]
ZDHHC17 protein networkhttps://string-db.org/network/9606.ENSP00000403397Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of cri [...]
CCPG1 protein networkhttps://string-db.org/network/9606.ENSP00000403400Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibitio [...]
ZNF30 protein networkhttps://string-db.org/network/9606.ENSP00000403441Zinc finger protein 30; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ODF2 protein networkhttps://string-db.org/network/9606.ENSP00000403453Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and princi [...]
GRB7 protein networkhttps://string-db.org/network/9606.ENSP00000403459Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-st [...]
CC2D2A protein networkhttps://string-db.org/network/9606.ENSP00000403465Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusio [...]
LTA protein networkhttps://string-db.org/network/9606.ENSP00000403495Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is prod [...]
BRAP protein networkhttps://string-db.org/network/9606.ENSP00000403524BRCA1-associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras respo [...]
GAMT protein networkhttps://string-db.org/network/9606.ENSP00000403536Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development.
C20orf173 protein networkhttps://string-db.org/network/9606.ENSP00000403566Uncharacterized protein C20orf173; Chromosome 20 open reading frame 173.
MRPL55 protein networkhttps://string-db.org/network/9606.ENSP00000403614Mitochondrial ribosomal protein L55.
DDC protein networkhttps://string-db.org/network/9606.ENSP00000403644Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs t [...]
TANGO2 protein networkhttps://string-db.org/network/9606.ENSP00000403645Transport and golgi organization 2 homolog.
CGB8 protein networkhttps://string-db.org/network/9606.ENSP00000403649Chorionic gonadotropin subunit beta 8.
MRGPRF protein networkhttps://string-db.org/network/9606.ENSP00000403660Mas-related G-protein coupled receptor member F; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain [...]
AP4M1 protein networkhttps://string-db.org/network/9606.ENSP00000403663AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They co [...]
PRM2 protein networkhttps://string-db.org/network/9606.ENSP00000403681Basic nuclear protein HPI1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and in [...]
NABP1 protein networkhttps://string-db.org/network/9606.ENSP00000403683SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as [...]
ARRB2 protein networkhttps://string-db.org/network/9606.ENSP00000403701Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous d [...]
USP17L10 protein networkhttps://string-db.org/network/9606.ENSP00000403760Ubiquitin carboxyl-terminal hydrolase 17-like protein 10; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
AASS protein networkhttps://string-db.org/network/9606.ENSP00000403768Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- ketoglutara [...]
FBXO10 protein networkhttps://string-db.org/network/9606.ENSP00000403802F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BC [...]
DISC1 protein networkhttps://string-db.org/network/9606.ENSP00000403888Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrica [...]
DMAC2 protein networkhttps://string-db.org/network/9606.ENSP00000403910Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of [...]
TBCEL protein networkhttps://string-db.org/network/9606.ENSP00000403925Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability.
EFCAB3 protein networkhttps://string-db.org/network/9606.ENSP00000403932EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3.
C11orf74 protein networkhttps://string-db.org/network/9606.ENSP00000403937Protein C11orf74; Seems to play a role in ciliary BBSome localization, maybe through interaction with IFT-A complex.
TENM1 protein networkhttps://string-db.org/network/9606.ENSP00000403954Teneurin C-terminal-associated peptide; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer [...]
CLDN34 protein networkhttps://string-db.org/network/9606.ENSP00000403980Claudin-34; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
ICA1 protein networkhttps://string-db.org/network/9606.ENSP00000403982Islet cell autoantigen 1; May play a role in neurotransmitter secretion.
C15orf40 protein networkhttps://string-db.org/network/9606.ENSP00000403987UPF0235 protein C15orf40; Chromosome 15 open reading frame 40.
TMED4 protein networkhttps://string-db.org/network/9606.ENSP00000404042Transmembrane emp24 domain-containing protein 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. A [...]
ZSCAN9 protein networkhttps://string-db.org/network/9606.ENSP00000404074Zinc finger and SCAN domain-containing protein 9; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DNAJB5 protein networkhttps://string-db.org/network/9606.ENSP00000404079DnaJ heat shock protein family member B5.
SMC6 protein networkhttps://string-db.org/network/9606.ENSP00000404092Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote siste [...]
ILF3 protein networkhttps://string-db.org/network/9606.ENSP00000404121Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-m [...]
IFT74 protein networkhttps://string-db.org/network/9606.ENSP00000404122Intraflagellar transport protein 74 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of [...]
TGFA protein networkhttps://string-db.org/network/9606.ENSP00000404131Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent c [...]
CEP170B protein networkhttps://string-db.org/network/9606.ENSP00000404151Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization.
RACGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000404190Rac GTPase-activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation duri [...]
CKMT2 protein networkhttps://string-db.org/network/9606.ENSP00000404203Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role [...]
CCDC155 protein networkhttps://string-db.org/network/9606.ENSP00000404220Protein KASH5; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic in [...]
EFHC2 protein networkhttps://string-db.org/network/9606.ENSP00000404232EF-hand domain-containing family member C2; EF-hand domain containing 2.
LILRA5 protein networkhttps://string-db.org/network/9606.ENSP00000404236Leukocyte immunoglobulin-like receptor subfamily A member 5; May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.
VGLL4 protein networkhttps://string-db.org/network/9606.ENSP00000404251Transcription cofactor vestigial-like protein 4; May act as a specific coactivator for the mammalian TEFs. Belongs to the vestigial family.
TCAF2 protein networkhttps://string-db.org/network/9606.ENSP00000404265TRPM8 channel-associated factor 2; [Isoform 2]: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate [...]
PRR20E protein networkhttps://string-db.org/network/9606.ENSP00000404281Proline rich 20E.
PLEKHA5 protein networkhttps://string-db.org/network/9606.ENSP00000404296Pleckstrin homology domain containing A5.
ARMCX4 protein networkhttps://string-db.org/network/9606.ENSP00000404304Armadillo repeat containing X-linked 4; Belongs to the eutherian X-chromosome-specific Armcx family.
RPL36A protein networkhttps://string-db.org/network/9606.ENSP00000404375Ribosomal protein L36a.
DNAJB14 protein networkhttps://string-db.org/network/9606.ENSP00000404381DnaJ homolog subfamily B member 14; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded prot [...]
LIMS4 protein networkhttps://string-db.org/network/9606.ENSP00000404432LIM and senescent cell antigen-like-containing domain protein 3; LIM zinc finger domain containing 4.
SOHLH1 protein networkhttps://string-db.org/network/9606.ENSP00000404438Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermat [...]
NPIPB4 protein networkhttps://string-db.org/network/9606.ENSP00000404439Nuclear pore complex interacting protein family member B4.
BBC3 protein networkhttps://string-db.org/network/9606.ENSP00000404503Bcl-2-binding component 3, isoforms 3/4; [Isoform 3]: Does not affect cell growth.
KRTAP21-3 protein networkhttps://string-db.org/network/9606.ENSP00000404517Keratin-associated protein 21-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
MYH13 protein networkhttps://string-db.org/network/9606.ENSP00000404570Myosin-13; Fast twitching myosin mediating the high-velocity and low- tension contractions of specific striated muscles.
EZH1 protein networkhttps://string-db.org/network/9606.ENSP00000404658Histone-lysine N-methyltransferase EZH1; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repressi [...]
PGGT1B protein networkhttps://string-db.org/network/9606.ENSP00000404676Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of p [...]
NAALADL2 protein networkhttps://string-db.org/network/9606.ENSP00000404705Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; May be catalytically inactive; Belongs to the peptidase M28 family. M28B subfamily.
TAPBP protein networkhttps://string-db.org/network/9606.ENSP00000404833Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
HEMK1 protein networkhttps://string-db.org/network/9606.ENSP00000404843MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondr [...]
NDRG1 protein networkhttps://string-db.org/network/9606.ENSP00000404854Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- [...]
SCHIP1 protein networkhttps://string-db.org/network/9606.ENSP00000404860Schwannomin interacting protein 1.
PRICKLE4 protein networkhttps://string-db.org/network/9606.ENSP00000404911Prickle planar cell polarity protein 4; Belongs to the prickle / espinas / testin family.
TECPR1 protein networkhttps://string-db.org/network/9606.ENSP00000404923Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by ass [...]
TMEM120B protein networkhttps://string-db.org/network/9606.ENSP00000404991Transmembrane protein 120B; Necessary for efficient adipogenesis. Belongs to the TMEM120 family.
ACVR1 protein networkhttps://string-db.org/network/9606.ENSP00000405004Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate [...]
WDR87 protein networkhttps://string-db.org/network/9606.ENSP00000405012WD repeat domain 87.
GSG1 protein networkhttps://string-db.org/network/9606.ENSP00000405032Germ cell-specific gene 1 protein; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.
NOP14 protein networkhttps://string-db.org/network/9606.ENSP00000405068Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP [...]
TAS2R39 protein networkhttps://string-db.org/network/9606.ENSP00000405095Taste receptor type 2 member 39; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
DHX57 protein networkhttps://string-db.org/network/9606.ENSP00000405111Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily.
LIMS3 protein networkhttps://string-db.org/network/9606.ENSP00000405165LIM zinc finger domain containing 3.
SPANXB1 protein networkhttps://string-db.org/network/9606.ENSP00000405202Sperm protein associated with the nucleus on the X chromosome B1; SPANX family member B1.
SPANXN4 protein networkhttps://string-db.org/network/9606.ENSP00000405210Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family.
ZNF347 protein networkhttps://string-db.org/network/9606.ENSP00000405218Zinc finger protein 347; May be involved in transcriptional regulation.
DCAF8L1 protein networkhttps://string-db.org/network/9606.ENSP00000405222DDB1- and CUL4-associated factor 8-like protein 1; DDB1 and CUL4 associated factor 8 like 1; Belongs to the WD repeat DCAF8 family.
AKAP7 protein networkhttps://string-db.org/network/9606.ENSP00000405252A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial [...]
ZNF778 protein networkhttps://string-db.org/network/9606.ENSP00000405289Zinc finger protein 778; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ETV1 protein networkhttps://string-db.org/network/9606.ENSP00000405327ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family.
ESR1 protein networkhttps://string-db.org/network/9606.ENSP00000405330Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differenti [...]
INPP5D protein networkhttps://string-db.org/network/9606.ENSP00000405338Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIn [...]
CA10 protein networkhttps://string-db.org/network/9606.ENSP00000405388Carbonic anhydrase-related protein 10; Does not have a catalytic activity; Belongs to the alpha-carbonic anhydrase family.
PHLDB2 protein networkhttps://string-db.org/network/9606.ENSP00000405405Pleckstrin homology-like domain family B member 2; Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsyn [...]
HHATL protein networkhttps://string-db.org/network/9606.ENSP00000405423Protein-cysteine N-palmitoyltransferase HHAT-like protein; Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN; Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
OXR1 protein networkhttps://string-db.org/network/9606.ENSP00000405424Oxidation resistance protein 1; May be involved in protection from oxidative damage.
MSR1 protein networkhttps://string-db.org/network/9606.ENSP00000405453Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits [...]
MDGA2 protein networkhttps://string-db.org/network/9606.ENSP00000405456MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions.
SVOPL protein networkhttps://string-db.org/network/9606.ENSP00000405482Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily.
PPP1R9A protein networkhttps://string-db.org/network/9606.ENSP00000405514Neurabin-1; Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha a [...]
GPI protein networkhttps://string-db.org/network/9606.ENSP00000405573Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeog [...]
TBL1XR1 protein networkhttps://string-db.org/network/9606.ENSP00000405574F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an [...]
CLMP protein networkhttps://string-db.org/network/9606.ENSP00000405577CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development [...]
DHX30 protein networkhttps://string-db.org/network/9606.ENSP00000405620ATP-dependent RNA helicase DHX30; RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger an [...]
CNEP1R1 protein networkhttps://string-db.org/network/9606.ENSP00000405635Nuclear envelope phosphatase-regulatory subunit 1; Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and [...]
NOL7 protein networkhttps://string-db.org/network/9606.ENSP00000405674Nucleolar protein 7.
ZNF837 protein networkhttps://string-db.org/network/9606.ENSP00000405699Zinc finger protein 837; May be involved in transcriptional regulation.
CDC45 protein networkhttps://string-db.org/network/9606.ENSP00000405726Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication; Belongs to the CDC45 family.
ESRP1 protein networkhttps://string-db.org/network/9606.ENSP00000405738Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelia [...]
SLC4A8 protein networkhttps://string-db.org/network/9606.ENSP00000405812Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in p [...]
RXFP1 protein networkhttps://string-db.org/network/9606.ENSP00000405841Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may a [...]
PBX1 protein networkhttps://string-db.org/network/9606.ENSP00000405890Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator [...]
AQP12A protein networkhttps://string-db.org/network/9606.ENSP00000405899Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
TMED7 protein networkhttps://string-db.org/network/9606.ENSP00000405926Transmembrane emp24 domain-containing protein 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted car [...]
PNCK protein networkhttps://string-db.org/network/9606.ENSP00000405950Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN [...]
RASGRF1 protein networkhttps://string-db.org/network/9606.ENSP00000405963Ras-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP.
SUMO2 protein networkhttps://string-db.org/network/9606.ENSP00000405965Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to it [...]
ACBD4 protein networkhttps://string-db.org/network/9606.ENSP00000405969Acyl-CoA-binding domain-containing protein 4; Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
LRRD1 protein networkhttps://string-db.org/network/9606.ENSP00000405987Leucine rich repeats and death domain containing 1.
IFT140 protein networkhttps://string-db.org/network/9606.ENSP00000406012Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPC [...]
UNC5C protein networkhttps://string-db.org/network/9606.ENSP00000406022Netrin receptor UNC5C; Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By si [...]
SH2D5 protein networkhttps://string-db.org/network/9606.ENSP00000406026SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
EPM2AIP1 protein networkhttps://string-db.org/network/9606.ENSP00000406027EPM2A interacting protein 1.
KAT8 protein networkhttps://string-db.org/network/9606.ENSP00000406037Histone acetyltransferase KAT8; Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acet [...]
TSGA13 protein networkhttps://string-db.org/network/9606.ENSP00000406047Testis-specific gene 13 protein; Testis specific 13.
HTR3E protein networkhttps://string-db.org/network/9606.ENSP000004060505-hydroxytryptamine receptor 3E; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...]
TDRD5 protein networkhttps://string-db.org/network/9606.ENSP00000406052Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integr [...]
PAPSS2 protein networkhttps://string-db.org/network/9606.ENSP00000406157Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. T [...]
PRMT1 protein networkhttps://string-db.org/network/9606.ENSP00000406162Protein arginine N-methyltransferase 1; Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1 [...]
GMNC protein networkhttps://string-db.org/network/9606.ENSP00000406164Geminin coiled-coil domain-containing protein 1; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L ont [...]
TRPV4 protein networkhttps://string-db.org/network/9606.ENSP00000406191Transient receptor potential cation channel subfamily V member 4; Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to h [...]
PAQR8 protein networkhttps://string-db.org/network/9606.ENSP00000406197Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similari [...]
ZNF160 protein networkhttps://string-db.org/network/9606.ENSP00000406201Zinc finger protein 160; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
EPN1 protein networkhttps://string-db.org/network/9606.ENSP00000406209Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By simi [...]
SLC13A5 protein networkhttps://string-db.org/network/9606.ENSP00000406220Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate ra [...]
FAT1 protein networkhttps://string-db.org/network/9606.ENSP00000406229Protocadherin Fat 1, nuclear form; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
ENPP3 protein networkhttps://string-db.org/network/9606.ENSP00000406261Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses du [...]
ZBTB7B protein networkhttps://string-db.org/network/9606.ENSP00000406286Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in [...]
TCEA3 protein networkhttps://string-db.org/network/9606.ENSP00000406293Transcription elongation factor A protein 3; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...]
ZNF880 protein networkhttps://string-db.org/network/9606.ENSP00000406318Zinc finger protein 880.
ADGRA2 protein networkhttps://string-db.org/network/9606.ENSP00000406367Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a [...]
DNAJC7 protein networkhttps://string-db.org/network/9606.ENSP00000406463DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progestero [...]
CDK15 protein networkhttps://string-db.org/network/9606.ENSP00000406472Cyclin-dependent kinase 15; Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'.
LILRB5 protein networkhttps://string-db.org/network/9606.ENSP00000406478Leukocyte immunoglobulin-like receptor subfamily B member 5; May act as receptor for class I MHC antigens.
THSD7A protein networkhttps://string-db.org/network/9606.ENSP00000406482Thrombospondin type-1 domain-containing protein 7A, soluble form; [Thrombospondin type-1 domain-containing protein 7A]: Plays a role in actin cytoskeleton rearrangement.
PMS1 protein networkhttps://string-db.org/network/9606.ENSP00000406490PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA.
C11orf21 protein networkhttps://string-db.org/network/9606.ENSP00000406541Uncharacterized protein C11orf21; Chromosome 11 open reading frame 21.
SLC23A3 protein networkhttps://string-db.org/network/9606.ENSP00000406546Solute carrier family 23 member 3; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
TAF1 protein networkhttps://string-db.org/network/9606.ENSP00000406549Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which [...]
CKMT1A protein networkhttps://string-db.org/network/9606.ENSP00000406577Creatine kinase, mitochondrial 1A.
HPF1 protein networkhttps://string-db.org/network/9606.ENSP00000406598Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid sp [...]
RNF224 protein networkhttps://string-db.org/network/9606.ENSP00000406665Ring finger protein 224.
MOGAT1 protein networkhttps://string-db.org/network/9606.ENSP000004066742-acylglycerol O-acyltransferase 1; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestin [...]
C5orf67 protein networkhttps://string-db.org/network/9606.ENSP00000406718Uncharacterized protein C5orf67; Chromosome 5 putative open reading frame 67.
GTF2IRD2 protein networkhttps://string-db.org/network/9606.ENSP00000406723General transcription factor II-I repeat domain-containing protein 2A; GTF2I repeat domain containing 2.
DCD protein networkhttps://string-db.org/network/9606.ENSP00000406773Survival-promoting peptide; DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective agai [...]
MUC6 protein networkhttps://string-db.org/network/9606.ENSP00000406861Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an im [...]
TMEM41A protein networkhttps://string-db.org/network/9606.ENSP00000406885Transmembrane protein 41A.
PHOSPHO1 protein networkhttps://string-db.org/network/9606.ENSP00000406909Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate [...]
ODAPH protein networkhttps://string-db.org/network/9606.ENSP00000406925Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite.
NT5DC2 protein networkhttps://string-db.org/network/9606.ENSP000004069335'-nucleotidase domain containing 2.
LAX1 protein networkhttps://string-db.org/network/9606.ENSP00000406970Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
GPR6 protein networkhttps://string-db.org/network/9606.ENSP00000406986G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity [...]
ZNF418 protein networkhttps://string-db.org/network/9606.ENSP00000407039Zinc finger protein 418; Transcriptional repressor.
FAM86B1 protein networkhttps://string-db.org/network/9606.ENSP00000407067Putative protein N-methyltransferase FAM86B1; Family with sequence similarity 86 member B1.
NIPAL2 protein networkhttps://string-db.org/network/9606.ENSP00000407087NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family.
NAPEPLD protein networkhttps://string-db.org/network/9606.ENSP00000407112N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the g [...]
SYBU protein networkhttps://string-db.org/network/9606.ENSP00000407118Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly duri [...]
ZNF410 protein networkhttps://string-db.org/network/9606.ENSP00000407130Zinc finger protein 410; Transcription factor that activates transcription of matrix- remodeling genes such as MMP1 during fibroblast senescence.
TNPO2 protein networkhttps://string-db.org/network/9606.ENSP00000407182Transportin-2; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate doc [...]
ARSG protein networkhttps://string-db.org/network/9606.ENSP00000407193Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbellife [...]
IQCA1 protein networkhttps://string-db.org/network/9606.ENSP00000407213Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the di [...]
GASK1A protein networkhttps://string-db.org/network/9606.ENSP00000407301Golgi associated kinase 1A; Belongs to the GASK family.
EBNA1BP2 protein networkhttps://string-db.org/network/9606.ENSP00000407323Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA.
NDUFB3 protein networkhttps://string-db.org/network/9606.ENSP00000407336NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
LMNTD1 protein networkhttps://string-db.org/network/9606.ENSP00000407353Lamin tail domain containing 1.
MUC7 protein networkhttps://string-db.org/network/9606.ENSP00000407422Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
HIPK1 protein networkhttps://string-db.org/network/9606.ENSP00000407442Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain t [...]
UNC45A protein networkhttps://string-db.org/network/9606.ENSP00000407487Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary fo [...]
SPINK8 protein networkhttps://string-db.org/network/9606.ENSP00000407497Serine protease inhibitor Kazal-type 8; Probable serine protease inhibitor.
PNPLA6 protein networkhttps://string-db.org/network/9606.ENSP00000407509Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 [...]
NUTM2E protein networkhttps://string-db.org/network/9606.ENSP00000407521NUT family member 2E; Belongs to the NUT family.
ZBTB22 protein networkhttps://string-db.org/network/9606.ENSP00000407545Zinc finger and BTB domain-containing protein 22; May be involved in transcriptional regulation.
CHRNA7 protein networkhttps://string-db.org/network/9606.ENSP00000407546Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...]
GAS7 protein networkhttps://string-db.org/network/9606.ENSP00000407552Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
SLC25A44 protein networkhttps://string-db.org/network/9606.ENSP00000407560Solute carrier family 25 member 44; Mitochondrial solute transporter which transports branched- chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue ( [...]
HRAS protein networkhttps://string-db.org/network/9606.ENSP00000407586GTPase HRas, N-terminally processed; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
KCNMB2 protein networkhttps://string-db.org/network/9606.ENSP00000407592Calcium-activated potassium channel subunit beta-2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...]
METTL6 protein networkhttps://string-db.org/network/9606.ENSP00000407613tRNA N(3)-methylcytidine methyltransferase METTL6; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of t [...]
PRR22 protein networkhttps://string-db.org/network/9606.ENSP00000407653Proline-rich protein 22; Proline rich 22.
TNXB protein networkhttps://string-db.org/network/9606.ENSP00000407685Tenascin-X; Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. [...]
VWA5A protein networkhttps://string-db.org/network/9606.ENSP00000407726Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is invo [...]
ACOXL protein networkhttps://string-db.org/network/9606.ENSP00000407761Acyl-coenzyme A oxidase-like protein; acyl-CoA oxidase like; Belongs to the acyl-CoA oxidase family.
CCDC122 protein networkhttps://string-db.org/network/9606.ENSP00000407763Coiled-coil domain containing 122.
USP46 protein networkhttps://string-db.org/network/9606.ENSP00000407818Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By si [...]
CNTN6 protein networkhttps://string-db.org/network/9606.ENSP00000407822Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTC [...]
NKX1-1 protein networkhttps://string-db.org/network/9606.ENSP00000407978NK1 transcription factor-related protein 1; NK1 homeobox 1; Belongs to the NK-1 homeobox family.
VRK2 protein networkhttps://string-db.org/network/9606.ENSP00000408002Serine/threonine-protein kinase VRK2; Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interl [...]
SLC9A3R2 protein networkhttps://string-db.org/network/9606.ENSP00000408005Na(+)/H(+) exchange regulatory cofactor NHE-RF2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the acti [...]
FBP1 protein networkhttps://string-db.org/network/9606.ENSP00000408025Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenes [...]
METTL11B protein networkhttps://string-db.org/network/9606.ENSP00000408058Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator [...]
GOLGA6B protein networkhttps://string-db.org/network/9606.ENSP00000408132Golgin A6 family member B; Belongs to the GOLGA6 family.
HLA-DPB1 protein networkhttps://string-db.org/network/9606.ENSP00000408146HLA class II histocompatibility antigen, DP beta 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...]
CT47A9 protein networkhttps://string-db.org/network/9606.ENSP00000408204Cancer/testis antigen family 47 member A9.
LPAR4 protein networkhttps://string-db.org/network/9606.ENSP00000408205Lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stim [...]
PPP1R3E protein networkhttps://string-db.org/network/9606.ENSP00000408288Protein phosphatase 1 regulatory subunit 3E; Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to [...]
TRIM32 protein networkhttps://string-db.org/network/9606.ENSP00000408292E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in media [...]
RFC5 protein networkhttps://string-db.org/network/9606.ENSP00000408295Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...]
PRAM1 protein networkhttps://string-db.org/network/9606.ENSP00000408342PML-RARA-regulated adapter molecule 1; May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
CHTF8 protein networkhttps://string-db.org/network/9606.ENSP00000408367Chromosome transmission fidelity protein 8 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear [...]
H7C2Y5_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000408410DnaJ_C domain-containing protein.
LAMP2 protein networkhttps://string-db.org/network/9606.ENSP00000408411Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and [...]
IMPA1 protein networkhttps://string-db.org/network/9606.ENSP00000408526Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological targe [...]
STPG4 protein networkhttps://string-db.org/network/9606.ENSP00000408527Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing [...]
TMEM132D protein networkhttps://string-db.org/network/9606.ENSP00000408581Transmembrane protein 132D; May serve as a cell-surface marker for oligodendrocyte differentiation.
PABPN1L protein networkhttps://string-db.org/network/9606.ENSP00000408598Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA.
HDAC9 protein networkhttps://string-db.org/network/9606.ENSP00000408617Histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
PRKCA protein networkhttps://string-db.org/network/9606.ENSP00000408695Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell prol [...]
NUGGC protein networkhttps://string-db.org/network/9606.ENSP00000408697Nuclear GTPase SLIP-GC; Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells [...]
SP8 protein networkhttps://string-db.org/network/9606.ENSP00000408792Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgro [...]
DCTN2 protein networkhttps://string-db.org/network/9606.ENSP00000408910Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring micr [...]
KIF5A protein networkhttps://string-db.org/network/9606.ENSP00000408979Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusi [...]
GDNF protein networkhttps://string-db.org/network/9606.ENSP00000409007Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptak [...]
TBRG1 protein networkhttps://string-db.org/network/9606.ENSP00000409016Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require eithe [...]
ZBTB42 protein networkhttps://string-db.org/network/9606.ENSP00000409107Zinc finger and BTB domain-containing protein 42; Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes.
ANO6 protein networkhttps://string-db.org/network/9606.ENSP00000409126Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling resu [...]
WSB2 protein networkhttps://string-db.org/network/9606.ENSP00000409131WD repeat and SOCS box-containing protein 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitina [...]
C10orf55 protein networkhttps://string-db.org/network/9606.ENSP00000409225Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55.
TRAPPC13 protein networkhttps://string-db.org/network/9606.ENSP00000409231Trafficking protein particle complex 13; Belongs to the TRAPPC13 family.
OTUD4 protein networkhttps://string-db.org/network/9606.ENSP00000409279OTU domain-containing protein 4; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regu [...]
RBM18 protein networkhttps://string-db.org/network/9606.ENSP00000409315RNA binding motif protein 18.
OR4F29 protein networkhttps://string-db.org/network/9606.ENSP00000409316Olfactory receptor family 4 subfamily F member 29.
ZNF230 protein networkhttps://string-db.org/network/9606.ENSP00000409318Zinc finger protein 230; May be involved in transcriptional regulation.
CISH protein networkhttps://string-db.org/network/9606.ENSP00000409346Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regu [...]
IQCF3 protein networkhttps://string-db.org/network/9606.ENSP00000409373IQ motif containing F3.
CHRM4 protein networkhttps://string-db.org/network/9606.ENSP00000409378Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...]
CRACR2A protein networkhttps://string-db.org/network/9606.ENSP00000409382EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as [...]
FAM47E protein networkhttps://string-db.org/network/9606.ENSP00000409423Protein FAM47E; Family with sequence similarity 47 member E.
ZNF740 protein networkhttps://string-db.org/network/9606.ENSP00000409463Zinc finger protein 740; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CCDC188 protein networkhttps://string-db.org/network/9606.ENSP00000409542Coiled-coil domain containing 188.
CLDN4 protein networkhttps://string-db.org/network/9606.ENSP00000409544Claudin-4; Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the k [...]
HERPUD1 protein networkhttps://string-db.org/network/9606.ENSP00000409555Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degra [...]
ARRB1 protein networkhttps://string-db.org/network/9606.ENSP00000409581Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous d [...]
ZFYVE27 protein networkhttps://string-db.org/network/9606.ENSP00000409594Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of [...]
ZNF766 protein networkhttps://string-db.org/network/9606.ENSP00000409652Zinc finger protein 766; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SUMO3 protein networkhttps://string-db.org/network/9606.ENSP00000409666Small ubiquitin like modifier 3.
SYNJ1 protein networkhttps://string-db.org/network/9606.ENSP00000409667Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosp [...]
TMBIM1 protein networkhttps://string-db.org/network/9606.ENSP00000409738Protein lifeguard 3; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling; Belongs to the BI1 family. LFG subfamily.
RPP21 protein networkhttps://string-db.org/network/9606.ENSP00000409799Ribonuclease P protein subunit p21; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
GAGE12J protein networkhttps://string-db.org/network/9606.ENSP00000409832G antigen 12J.
TMEM159 protein networkhttps://string-db.org/network/9606.ENSP00000409879Promethin; Transmembrane protein 159; Belongs to the TMEM159 family.
CCNB1IP1 protein networkhttps://string-db.org/network/9606.ENSP00000409896E3 ubiquitin-protein ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS [...]
USP53 protein networkhttps://string-db.org/network/9606.ENSP00000409906Inactive ubiquitin carboxyl-terminal hydrolase 53; Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier propertie [...]
PTGES3L-AARSD1 protein networkhttps://string-db.org/network/9606.ENSP00000409924PTGES3L-AARSD1 readthrough.
C2CD6 protein networkhttps://string-db.org/network/9606.ENSP00000409937C2 calcium-dependent domain-containing protein 6; C2 calcium dependent domain containing 6.
ANHX protein networkhttps://string-db.org/network/9606.ENSP00000409950Anomalous homeobox.
VPS52 protein networkhttps://string-db.org/network/9606.ENSP00000409952Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...]
CFAP97 protein networkhttps://string-db.org/network/9606.ENSP00000409964Cilia and flagella associated protein 97.
FBXO46 protein networkhttps://string-db.org/network/9606.ENSP00000410007F-box only protein 46; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
PHGR1 protein networkhttps://string-db.org/network/9606.ENSP00000410024Proline, histidine and glycine rich 1.
SKIDA1 protein networkhttps://string-db.org/network/9606.ENSP00000410041SKI/DACH domain containing 1; Belongs to the DACH/dachshund family.
BRD1 protein networkhttps://string-db.org/network/9606.ENSP00000410042Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
EEF1D protein networkhttps://string-db.org/network/9606.ENSP00000410059Elongation factor 1-delta; [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs [...]
VEZT protein networkhttps://string-db.org/network/9606.ENSP00000410083Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation pr [...]
TBC1D26 protein networkhttps://string-db.org/network/9606.ENSP00000410111TBC1 domain family member 26; May act as a GTPase-activating protein for Rab family protein(s).
ABTB2 protein networkhttps://string-db.org/network/9606.ENSP00000410157Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth.
AK9 protein networkhttps://string-db.org/network/9606.ENSP00000410186Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate k [...]
ZSCAN2 protein networkhttps://string-db.org/network/9606.ENSP00000410198Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis.
POC5 protein networkhttps://string-db.org/network/9606.ENSP00000410216Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family.
IGF2BP2 protein networkhttps://string-db.org/network/9606.ENSP00000410242Insulin-like growth factor 2 mRNA-binding protein 2; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows m [...]
TMEM176B protein networkhttps://string-db.org/network/9606.ENSP00000410269Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).
FGFR2 protein networkhttps://string-db.org/network/9606.ENSP00000410294Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, [...]
PDE1A protein networkhttps://string-db.org/network/9606.ENSP00000410309Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regul [...]
TOMM40 protein networkhttps://string-db.org/network/9606.ENSP00000410339Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria; Belongs to the Tom40 family.
CMSS1 protein networkhttps://string-db.org/network/9606.ENSP00000410396Protein CMSS1; Cms1 ribosomal small subunit homolog.
CT47A11 protein networkhttps://string-db.org/network/9606.ENSP00000410400Cancer/testis antigen family 47 member A11.
MAP2K4 protein networkhttps://string-db.org/network/9606.ENSP00000410402Dual specificity mitogen-activated protein kinase kinase 4; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component [...]
TAF1D protein networkhttps://string-db.org/network/9606.ENSP00000410409TATA box-binding protein-associated factor RNA polymerase I subunit D; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation comple [...]
TRIM26 protein networkhttps://string-db.org/network/9606.ENSP00000410446Tripartite motif-containing protein 26; E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors [...]
STMN1 protein networkhttps://string-db.org/network/9606.ENSP00000410452Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 m [...]
ZNF90 protein networkhttps://string-db.org/network/9606.ENSP00000410466Zinc finger protein 90; May be involved in transcriptional regulation.
FAHD2B protein networkhttps://string-db.org/network/9606.ENSP00000410470Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity.
LTB protein networkhttps://string-db.org/network/9606.ENSP00000410481Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the [...]
RNF223 protein networkhttps://string-db.org/network/9606.ENSP00000410533Ring finger protein 223.
ZNF814 protein networkhttps://string-db.org/network/9606.ENSP00000410545Zinc finger protein 814.
SIMC1 protein networkhttps://string-db.org/network/9606.ENSP00000410552SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1.
CDK3 protein networkhttps://string-db.org/network/9606.ENSP00000410561Cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts wit [...]
CELF4 protein networkhttps://string-db.org/network/9606.ENSP00000410584CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissu [...]
FAM131B protein networkhttps://string-db.org/network/9606.ENSP00000410603Protein FAM131B; Family with sequence similarity 131 member B; Belongs to the FAM131 family.
AFAP1 protein networkhttps://string-db.org/network/9606.ENSP00000410689Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipod [...]
SFRP4 protein networkhttps://string-db.org/network/9606.ENSP00000410715Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...]
GABRG2 protein networkhttps://string-db.org/network/9606.ENSP00000410732Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. [...]
ZNF562 protein networkhttps://string-db.org/network/9606.ENSP00000410734Zinc finger protein 562; May be involved in transcriptional regulation.
DOCK4 protein networkhttps://string-db.org/network/9606.ENSP00000410746Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activ [...]
LSM5 protein networkhttps://string-db.org/network/9606.ENSP00000410758U6 snRNA-associated Sm-like protein LSm5; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
ATXN7L1 protein networkhttps://string-db.org/network/9606.ENSP00000410759Ataxin-7-like protein 1; Ataxin 7 like 1.
FAM135A protein networkhttps://string-db.org/network/9606.ENSP00000410768Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family.
CNBP protein networkhttps://string-db.org/network/9606.ENSP00000410769Cellular nucleic acid-binding protein; Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
FCGRT protein networkhttps://string-db.org/network/9606.ENSP00000410798IgG receptor FcRn large subunit p51; Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and med [...]
FIGNL1 protein networkhttps://string-db.org/network/9606.ENSP00000410811Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-depe [...]
B4E1Z4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000410815cDNA FLJ55673, highly similar to Complement factor B; Belongs to the peptidase S1 family.
MAD2L1BP protein networkhttps://string-db.org/network/9606.ENSP00000410818MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 comple [...]
GBE1 protein networkhttps://string-db.org/network/9606.ENSP000004108331,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Be [...]
TMEM132C protein networkhttps://string-db.org/network/9606.ENSP00000410852Transmembrane protein 132C.
NHLRC4 protein networkhttps://string-db.org/network/9606.ENSP00000410858NHL-repeat-containing protein 4; NHL repeat containing 4.
RUNDC3A protein networkhttps://string-db.org/network/9606.ENSP00000410862RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family.
ZNF783 protein networkhttps://string-db.org/network/9606.ENSP00000410890Protein ZNF783; May be involved in transcriptional regulation.
MUSTN1 protein networkhttps://string-db.org/network/9606.ENSP00000410910Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system; Belongs to the MUSTANG family.
LMLN protein networkhttps://string-db.org/network/9606.ENSP00000410926Leishmanolysin-like peptidase; Metalloprotease.
TSPYL4 protein networkhttps://string-db.org/network/9606.ENSP00000410943Testis-specific Y-encoded-like protein 4; TSPY like 4.
ERLIN1 protein networkhttps://string-db.org/network/9606.ENSP00000410964Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation o [...]
MOGS protein networkhttps://string-db.org/network/9606.ENSP00000410992Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glyc [...]
DNTTIP2 protein networkhttps://string-db.org/network/9606.ENSP00000411010Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.
NSMAF protein networkhttps://string-db.org/network/9606.ENSP00000411012Protein FAN; Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production [...]
TMPRSS3 protein networkhttps://string-db.org/network/9606.ENSP00000411013Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is r [...]
ZNF284 protein networkhttps://string-db.org/network/9606.ENSP00000411032Zinc finger protein 284; May be involved in transcriptional regulation.
LCE6A protein networkhttps://string-db.org/network/9606.ENSP00000411070Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum. Belongs to the LCE family.
BCL7B protein networkhttps://string-db.org/network/9606.ENSP00000411073B-cell CLL/lymphoma 7 protein family member B; Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 [...]
ZNF799 protein networkhttps://string-db.org/network/9606.ENSP00000411084Zinc finger protein 799; May be involved in transcriptional regulation.
ABCA13 protein networkhttps://string-db.org/network/9606.ENSP00000411096ATP binding cassette subfamily A member 13; Belongs to the ABC transporter superfamily.
TLK1 protein networkhttps://string-db.org/network/9606.ENSP00000411099Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle chec [...]
BEGAIN protein networkhttps://string-db.org/network/9606.ENSP00000411124Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD).
ZNF619 protein networkhttps://string-db.org/network/9606.ENSP00000411132Zinc finger protein 619; May be involved in transcriptional regulation.
NPIPB15 protein networkhttps://string-db.org/network/9606.ENSP00000411140Nuclear pore complex interacting protein family member B15.
FEZF1 protein networkhttps://string-db.org/network/9606.ENSP00000411145Fez family zinc finger protein 1; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of [...]
ITPKB protein networkhttps://string-db.org/network/9606.ENSP00000411152Inositol-trisphosphate 3-kinase B.
TBC1D9 protein networkhttps://string-db.org/network/9606.ENSP00000411197TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s).
KRTAP4-16 protein networkhttps://string-db.org/network/9606.ENSP00000411198Keratin associated protein 4-16.
FNDC3B protein networkhttps://string-db.org/network/9606.ENSP00000411242Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis.
TBCCD1 protein networkhttps://string-db.org/network/9606.ENSP00000411253TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration.
GABARAPL1 protein networkhttps://string-db.org/network/9606.ENSP00000411256Gamma-aminobutyric acid receptor-associated protein-like 1; GABA type A receptor associated protein like 1.
BEND3 protein networkhttps://string-db.org/network/9606.ENSP00000411268BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoyla [...]
PTPRC protein networkhttps://string-db.org/network/9606.ENSP00000411355Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation [...]
FAM200A protein networkhttps://string-db.org/network/9606.ENSP00000411372Protein FAM200A; Family with sequence similarity 200 member A; Belongs to the FAM200 family.
MARK3 protein networkhttps://string-db.org/network/9606.ENSP00000411397MAP/microtubule affinity-regulating kinase 3; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the mi [...]
RAB3GAP1 protein networkhttps://string-db.org/network/9606.ENSP00000411418Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins [...]
PATE4 protein networkhttps://string-db.org/network/9606.ENSP00000411439Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.
ABCF3 protein networkhttps://string-db.org/network/9606.ENSP00000411471ATP-binding cassette sub-family F member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.
FAM153A protein networkhttps://string-db.org/network/9606.ENSP00000411506Protein FAM153A; Family with sequence similarity 153 member A; Belongs to the FAM153 family.
TOP2A protein networkhttps://string-db.org/network/9606.ENSP00000411532DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitos [...]
DHRS12 protein networkhttps://string-db.org/network/9606.ENSP00000411565Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
MSANTD1 protein networkhttps://string-db.org/network/9606.ENSP00000411584Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1.
GLRA1 protein networkhttps://string-db.org/network/9606.ENSP00000411593Glycine receptor subunit alpha-1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and bet [...]
AOC1 protein networkhttps://string-db.org/network/9606.ENSP00000411613Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune r [...]
ATP6V0E2 protein networkhttps://string-db.org/network/9606.ENSP00000411672V-type proton ATPase subunit e 2; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the V-ATPase e1/e2 subunit family.
MPST protein networkhttps://string-db.org/network/9606.ENSP000004117193-mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynt [...]
COLEC11 protein networkhttps://string-db.org/network/9606.ENSP00000411770Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharide [...]
GPR35 protein networkhttps://string-db.org/network/9606.ENSP00000411788G-protein coupled receptor 35; Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calc [...]
CSGALNACT1 protein networkhttps://string-db.org/network/9606.ENSP00000411816Chondroitin sulfate N-acetylgalactosaminyltransferase 1; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of [...]
ALDH3A1 protein networkhttps://string-db.org/network/9606.ENSP00000411821Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, [...]
ISY1-RAB43 protein networkhttps://string-db.org/network/9606.ENSP00000411822Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Requir [...]
PDCD6IP protein networkhttps://string-db.org/network/9606.ENSP00000411825Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junc [...]
GPR137 protein networkhttps://string-db.org/network/9606.ENSP00000411827Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy ; Belongs to the GPR137 family.
KIF21B protein networkhttps://string-db.org/network/9606.ENSP00000411831Kinesin-like protein KIF21B; Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neur [...]
MARCHF8 protein networkhttps://string-db.org/network/9606.ENSP00000411848Membrane associated ring-CH-type finger 8.
EPGN protein networkhttps://string-db.org/network/9606.ENSP00000411898Epigen; Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.
CT47A10 protein networkhttps://string-db.org/network/9606.ENSP00000411909Cancer/testis antigen family 47 member A10.
LMOD2 protein networkhttps://string-db.org/network/9606.ENSP00000411932Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcome [...]
IFNA17 protein networkhttps://string-db.org/network/9606.ENSP00000411940Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs [...]
SAPCD1 protein networkhttps://string-db.org/network/9606.ENSP00000411948Suppressor APC domain containing 1.
HSD17B4 protein networkhttps://string-db.org/network/9606.ENSP00000411960Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both [...]
PRR13 protein networkhttps://string-db.org/network/9606.ENSP00000412064Proline-rich protein 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.
MRVI1 protein networkhttps://string-db.org/network/9606.ENSP00000412130Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular sto [...]
CCDC121 protein networkhttps://string-db.org/network/9606.ENSP00000412150Coiled-coil domain containing 121.
DGKZ protein networkhttps://string-db.org/network/9606.ENSP00000412178Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. I [...]
PGAM4 protein networkhttps://string-db.org/network/9606.ENSP00000412189Phosphoglycerate mutase family member 4.
IL5RA protein networkhttps://string-db.org/network/9606.ENSP00000412209Interleukin-5 receptor subunit alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5; Belongs to the type I cytokine receptor family. Type 5 subfamily.
C4orf45 protein networkhttps://string-db.org/network/9606.ENSP00000412215Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45.
IL10 protein networkhttps://string-db.org/network/9606.ENSP00000412237Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inf [...]
DEPDC1 protein networkhttps://string-db.org/network/9606.ENSP00000412292DEP domain-containing protein 1A; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by [...]
MBD3 protein networkhttps://string-db.org/network/9606.ENSP00000412302Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing meth [...]
PPP2R5C protein networkhttps://string-db.org/network/9606.ENSP00000412324Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...]
ARPP21 protein networkhttps://string-db.org/network/9606.ENSP00000412326cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons.
SIGLEC11 protein networkhttps://string-db.org/network/9606.ENSP00000412361Sialic acid-binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recog [...]
ZNF438 protein networkhttps://string-db.org/network/9606.ENSP00000412363Zinc finger protein 438; Isoform 1 acts as a transcriptional repressor.
AJM1 protein networkhttps://string-db.org/network/9606.ENSP00000412388Apical junction component 1 homolog; May be involved in the control of adherens junction integrity.
F6UB75_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000412457MHC_II_beta domain-containing protein.
ARHGAP22 protein networkhttps://string-db.org/network/9606.ENSP00000412461Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a [...]
MYEOV protein networkhttps://string-db.org/network/9606.ENSP00000412482Myeloma-overexpressed gene protein; Myeloma overexpressed.
TMEM169 protein networkhttps://string-db.org/network/9606.ENSP00000412524Transmembrane protein 169.
SNRPB protein networkhttps://string-db.org/network/9606.ENSP00000412566Small nuclear ribonucleoprotein-associated proteins B and B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of [...]
GABRR1 protein networkhttps://string-db.org/network/9606.ENSP00000412673Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...]
RMND1 protein networkhttps://string-db.org/network/9606.ENSP00000412708Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome ; Belongs to th [...]
OSBPL9 protein networkhttps://string-db.org/network/9606.ENSP00000412733Oxysterol binding protein like 9; Belongs to the OSBP family.
OR4A47 protein networkhttps://string-db.org/network/9606.ENSP00000412752Olfactory receptor 4A47; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MALRD1 protein networkhttps://string-db.org/network/9606.ENSP00000412763MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis.
IKZF2 protein networkhttps://string-db.org/network/9606.ENSP00000412869Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin.
CAMTA2 protein networkhttps://string-db.org/network/9606.ENSP00000412886Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor. Belongs to the CAMTA family.
RPP14 protein networkhttps://string-db.org/network/9606.ENSP00000412894Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNa [...]
IFNA4 protein networkhttps://string-db.org/network/9606.ENSP00000412897Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...]
FREM1 protein networkhttps://string-db.org/network/9606.ENSP00000412940FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belo [...]
TSPY3 protein networkhttps://string-db.org/network/9606.ENSP00000412988Testis specific protein Y-linked 3.
ZNF805 protein networkhttps://string-db.org/network/9606.ENSP00000412999Zinc finger protein 805; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
AGBL1 protein networkhttps://string-db.org/network/9606.ENSP00000413001Cytosolic carboxypeptidase 4; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...]
CCDC28B protein networkhttps://string-db.org/network/9606.ENSP00000413017Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex [...]
C7orf25 protein networkhttps://string-db.org/network/9606.ENSP00000413029UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family.
RBFOX2 protein networkhttps://string-db.org/network/9606.ENSP00000413035RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulate [...]
NAT8L protein networkhttps://string-db.org/network/9606.ENSP00000413064N-acetylaspartate synthetase; Plays a role in the regulation of lipogenesis by producing N- acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and [...]
MICA protein networkhttps://string-db.org/network/9606.ENSP00000413079MHC class I polypeptide-related sequence A; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NK [...]
SCAF8 protein networkhttps://string-db.org/network/9606.ENSP00000413098SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alterna [...]
C16orf91 protein networkhttps://string-db.org/network/9606.ENSP00000413100Protein CCSMST1; Chromosome 16 open reading frame 91.
C1orf226 protein networkhttps://string-db.org/network/9606.ENSP00000413150Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226.
FKBP7 protein networkhttps://string-db.org/network/9606.ENSP00000413152Peptidyl-prolyl cis-trans isomerase FKBP7; PPIases accelerate the folding of proteins during protein synthesis.
RAB34 protein networkhttps://string-db.org/network/9606.ENSP00000413156Ras-related protein Rab-34; Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf patho [...]
TMEM130 protein networkhttps://string-db.org/network/9606.ENSP00000413163Transmembrane protein 130.
FAM160A1 protein networkhttps://string-db.org/network/9606.ENSP00000413196Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family.
PRXL2B protein networkhttps://string-db.org/network/9606.ENSP00000413218Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostagla [...]
SLC66A1L protein networkhttps://string-db.org/network/9606.ENSP00000413228Putative uncharacterized protein SLC66A1L; Solute carrier family 66 member 1 like.
PIGZ protein networkhttps://string-db.org/network/9606.ENSP00000413405GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly. T [...]
ZNF724 protein networkhttps://string-db.org/network/9606.ENSP00000413411Zinc finger protein 724; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZFHX2 protein networkhttps://string-db.org/network/9606.ENSP00000413418Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli.
RPL10 protein networkhttps://string-db.org/network/9606.ENSP0000041343660S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development.
KIAA1324L protein networkhttps://string-db.org/network/9606.ENSP00000413445UPF0577 protein KIAA1324-like; Belongs to the UPF0577 family.
KRT3 protein networkhttps://string-db.org/network/9606.ENSP00000413479Keratin, type II cytoskeletal 3; Keratin 3; Belongs to the intermediate filament family.
FGF12 protein networkhttps://string-db.org/network/9606.ENSP00000413496Fibroblast growth factor 12; Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by e [...]
SEPTIN7 protein networkhttps://string-db.org/network/9606.ENSP00000413507Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for nor [...]
HID1 protein networkhttps://string-db.org/network/9606.ENSP00000413520Protein HID1; May play an important role in the development of cancers in a broad range of tissues.
NLE1 protein networkhttps://string-db.org/network/9606.ENSP00000413572Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Not [...]
CROT protein networkhttps://string-db.org/network/9606.ENSP00000413575Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxi [...]
RFESD protein networkhttps://string-db.org/network/9606.ENSP00000413592Rieske domain-containing protein; Rieske Fe-S domain containing.
STXBP2 protein networkhttps://string-db.org/network/9606.ENSP00000413606Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-eth [...]
FNBP1 protein networkhttps://string-db.org/network/9606.ENSP00000413625Formin-binding protein 1; May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the [...]
MCMDC2 protein networkhttps://string-db.org/network/9606.ENSP00000413632Minichromosome maintenance domain-containing protein 2; Plays an important role in meiotic recombination and associated DNA double-strand break repair.
ZNF492 protein networkhttps://string-db.org/network/9606.ENSP00000413660Zinc finger protein 492; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TOM1 protein networkhttps://string-db.org/network/9606.ENSP00000413697Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family.
LRRC15 protein networkhttps://string-db.org/network/9606.ENSP00000413707Leucine-rich repeat-containing protein 15; Leucine rich repeat containing 15.
CDKN1C protein networkhttps://string-db.org/network/9606.ENSP00000413720Cyclin-dependent kinase inhibitor 1C; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cy [...]
C12orf71 protein networkhttps://string-db.org/network/9606.ENSP00000413728Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71.
SIGLEC9 protein networkhttps://string-db.org/network/9606.ENSP00000413861Sialic acid-binding Ig-like lectin 9; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sial [...]
FAM25G protein networkhttps://string-db.org/network/9606.ENSP00000413896Family with sequence similarity 25 member G.
BCS1L protein networkhttps://string-db.org/network/9606.ENSP00000413908Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, re [...]
RCOR3 protein networkhttps://string-db.org/network/9606.ENSP00000413929REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family.
INPP5K protein networkhttps://string-db.org/network/9606.ENSP00000413937Inositol polyphosphate 5-phosphatase K; Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphati [...]
GDPD2 protein networkhttps://string-db.org/network/9606.ENSP00000414019Glycerophosphoinositol inositolphosphodiesterase GDPD2; Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for othe [...]
PERM1 protein networkhttps://string-db.org/network/9606.ENSP00000414022PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contr [...]
NRBP2 protein networkhttps://string-db.org/network/9606.ENSP00000414055Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation.
SDHAF3 protein networkhttps://string-db.org/network/9606.ENSP00000414066Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...]
J3KR12_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000414068Uncharacterized protein.
CUL2 protein networkhttps://string-db.org/network/9606.ENSP00000414095Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS co [...]
HJURP protein networkhttps://string-db.org/network/9606.ENSP00000414109Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chape [...]
SPART protein networkhttps://string-db.org/network/9606.ENSP00000414147Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
ERG protein networkhttps://string-db.org/network/9606.ENSP00000414150Transcriptional regulator ERG; Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of [...]
MTMR1 protein networkhttps://string-db.org/network/9606.ENSP00000414178Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4 [...]
PPP6R1 protein networkhttps://string-db.org/network/9606.ENSP00000414202Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphory [...]
HSBP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000414236Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family.
INTS2 protein networkhttps://string-db.org/network/9606.ENSP00000414237Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
CT47A2 protein networkhttps://string-db.org/network/9606.ENSP00000414253Cancer/testis antigen family 47 member A2.
MST1 protein networkhttps://string-db.org/network/9606.ENSP00000414287Hepatocyte growth factor-like protein alpha chain; Macrophage stimulating 1.
SRSF12 protein networkhttps://string-db.org/network/9606.ENSP00000414302Serine/arginine-rich splicing factor 12; Splicing factor that seems to antagonize SR proteins in pre- mRNA splicing regulation.
BDNF protein networkhttps://string-db.org/network/9606.ENSP00000414303Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected ne [...]
RPS24 protein networkhttps://string-db.org/network/9606.ENSP0000041432140S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family.
RIMKLA protein networkhttps://string-db.org/network/9606.ENSP00000414330N-acetylaspartylglutamate synthase A; Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate. Belongs to the RimK family.
MUC20 protein networkhttps://string-db.org/network/9606.ENSP00000414350Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS path [...]
PSMA1 protein networkhttps://string-db.org/network/9606.ENSP00000414359Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...]
EFNA4 protein networkhttps://string-db.org/network/9606.ENSP00000414378Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...]
CFAP300 protein networkhttps://string-db.org/network/9606.ENSP00000414390Cilia- and flagella-associated protein 300; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm [...]
USP17L13 protein networkhttps://string-db.org/network/9606.ENSP00000414392Ubiquitin carboxyl-terminal hydrolase 17-like protein 13; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
DNAJB11 protein networkhttps://string-db.org/network/9606.ENSP00000414398DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substr [...]
FAM177B protein networkhttps://string-db.org/network/9606.ENSP00000414451Protein FAM177B; Family with sequence similarity 177 member B.
SS18 protein networkhttps://string-db.org/network/9606.ENSP00000414516Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function [...]
MAMLD1 protein networkhttps://string-db.org/network/9606.ENSP00000414517Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belong [...]
MID1 protein networkhttps://string-db.org/network/9606.ENSP00000414521E3 ubiquitin-protein ligase Midline-1; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphat [...]
ABHD4 protein networkhttps://string-db.org/network/9606.ENSP00000414558(Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endoc [...]
EFCC1 protein networkhttps://string-db.org/network/9606.ENSP00000414597EF-hand and coiled-coil domain containing 1.
PRPSAP1 protein networkhttps://string-db.org/network/9606.ENSP00000414624Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
LRRC34 protein networkhttps://string-db.org/network/9606.ENSP00000414635Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression o [...]
CARF protein networkhttps://string-db.org/network/9606.ENSP00000414644Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calci [...]
OSR2 protein networkhttps://string-db.org/network/9606.ENSP00000414657Protein odd-skipped-related 2; Odd-skipped related transciption factor 2.
LMOD3 protein networkhttps://string-db.org/network/9606.ENSP00000414670Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization ; Belongs to the tropomodulin family.
WBP1L protein networkhttps://string-db.org/network/9606.ENSP00000414721WW domain binding protein 1 like.
SKOR2 protein networkhttps://string-db.org/network/9606.ENSP00000414750SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system.
TMEM64 protein networkhttps://string-db.org/network/9606.ENSP00000414786Transmembrane protein 64; Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which [...]
ELP2 protein networkhttps://string-db.org/network/9606.ENSP00000414851Elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in trans [...]
SPARCL1 protein networkhttps://string-db.org/network/9606.ENSP00000414856SPARC-like protein 1; SPARC like 1.
HYLS1 protein networkhttps://string-db.org/network/9606.ENSP00000414884Hydrolethalus syndrome protein 1; Plays a role in ciliogenesis.
KCNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000414886Kv channel-interacting protein 1; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate o [...]
ZNF879 protein networkhttps://string-db.org/network/9606.ENSP00000414887Zinc finger protein 879; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CTSO protein networkhttps://string-db.org/network/9606.ENSP00000414904Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family.
DCTN4 protein networkhttps://string-db.org/network/9606.ENSP00000414906Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles [...]
C1orf167 protein networkhttps://string-db.org/network/9606.ENSP00000414909Uncharacterized protein C1orf167; Chromosome 1 open reading frame 167.
SPATA24 protein networkhttps://string-db.org/network/9606.ENSP00000414920Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and [...]
PTBP3 protein networkhttps://string-db.org/network/9606.ENSP00000414921Polypyrimidine tract-binding protein 3; RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migra [...]
USP41 protein networkhttps://string-db.org/network/9606.ENSP00000414922Putative ubiquitin carboxyl-terminal hydrolase 41; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as wel [...]
CCDC107 protein networkhttps://string-db.org/network/9606.ENSP00000414964Coiled-coil domain containing 107.
KLC1 protein networkhttps://string-db.org/network/9606.ENSP00000414982Kinesin light chain 1; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...]
SLC30A8 protein networkhttps://string-db.org/network/9606.ENSP00000415011Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin ma [...]
PRRT4 protein networkhttps://string-db.org/network/9606.ENSP00000415026Proline rich transmembrane protein 4.
C16orf96 protein networkhttps://string-db.org/network/9606.ENSP00000415027Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96.
TMEM171 protein networkhttps://string-db.org/network/9606.ENSP00000415030Transmembrane protein 171.
NBEAL2 protein networkhttps://string-db.org/network/9606.ENSP00000415034Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogen [...]
GSDMB protein networkhttps://string-db.org/network/9606.ENSP00000415049Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Proba [...]
EXD1 protein networkhttps://string-db.org/network/9606.ENSP00000415056piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates [...]
ZNF177 protein networkhttps://string-db.org/network/9606.ENSP00000415070Zinc finger protein 177; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CACTIN protein networkhttps://string-db.org/network/9606.ENSP00000415078Cactin; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways. Con [...]
MYO7B protein networkhttps://string-db.org/network/9606.ENSP00000415090Unconventional myosin-VIIb; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relati [...]
TICAM2 protein networkhttps://string-db.org/network/9606.ENSP00000415139TIR domain-containing adapter molecule 2; Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling [...]
CBFB protein networkhttps://string-db.org/network/9606.ENSP00000415151Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their t [...]
PIGG protein networkhttps://string-db.org/network/9606.ENSP00000415203GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second manno [...]
NPIPB7 protein networkhttps://string-db.org/network/9606.ENSP00000415207Nuclear pore complex interacting protein family member B7.
SKIL protein networkhttps://string-db.org/network/9606.ENSP00000415243Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals; Belongs to the SKI family.
ICAM2 protein networkhttps://string-db.org/network/9606.ENSP00000415283Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA- [...]
FAM221B protein networkhttps://string-db.org/network/9606.ENSP00000415299Protein FAM221B; Family with sequence similarity 221 member B.
SESTD1 protein networkhttps://string-db.org/network/9606.ENSP00000415332SEC14 domain and spectrin repeat-containing protein 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5 [...]
TRIB3 protein networkhttps://string-db.org/network/9606.ENSP00000415416Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr- 308' phosphorylation site in AKT1. Binds t [...]
GTSE1 protein networkhttps://string-db.org/network/9606.ENSP00000415430G2 and S phase-expressed protein 1; May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpressio [...]
INTS12 protein networkhttps://string-db.org/network/9606.ENSP00000415433Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Int [...]
USP40 protein networkhttps://string-db.org/network/9606.ENSP00000415434Ubiquitin carboxyl-terminal hydrolase 40; May be catalytically inactive; Belongs to the peptidase C19 family.
KANSL2 protein networkhttps://string-db.org/network/9606.ENSP00000415436KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...]
GCNT1 protein networkhttps://string-db.org/network/9606.ENSP00000415454Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-gl [...]
LARP4 protein networkhttps://string-db.org/network/9606.ENSP00000415464La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA tr [...]
TSBP1 protein networkhttps://string-db.org/network/9606.ENSP00000415517Testis expressed basic protein 1.
CCDC81 protein networkhttps://string-db.org/network/9606.ENSP00000415528Coiled-coil domain containing 81.
POLR2H protein networkhttps://string-db.org/network/9606.ENSP00000415536DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...]
DCAF11 protein networkhttps://string-db.org/network/9606.ENSP00000415556DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
CTCFL protein networkhttps://string-db.org/network/9606.ENSP00000415579Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigen [...]
ENSP00000415609 protein networkhttps://string-db.org/network/9606.ENSP00000415609Novel protein.
CFAP97D1 protein networkhttps://string-db.org/network/9606.ENSP00000415662Uncharacterized protein CFAP97D1; CFAP97 domain containing 1; Belongs to the CFAP97 family.
GGTLC2 protein networkhttps://string-db.org/network/9606.ENSP00000415676Gamma-glutamyltransferase light chain 2; Belongs to the gamma-glutamyltransferase family.
RNF10 protein networkhttps://string-db.org/network/9606.ENSP00000415682RING finger protein 10; Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.
CD36 protein networkhttps://string-db.org/network/9606.ENSP00000415743Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyl [...]
ITIH3 protein networkhttps://string-db.org/network/9606.ENSP00000415769Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...]
ZNF732 protein networkhttps://string-db.org/network/9606.ENSP00000415774Zinc finger protein 732; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SERPINE2 protein networkhttps://string-db.org/network/9606.ENSP00000415786Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin; Belongs to the serpin family [...]
ATXN1L protein networkhttps://string-db.org/network/9606.ENSP00000415822Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, alon [...]
IGFL1 protein networkhttps://string-db.org/network/9606.ENSP00000415823Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor.
ZNF276 protein networkhttps://string-db.org/network/9606.ENSP00000415836Zinc finger protein 276; May be involved in transcriptional regulation.
C4B protein networkhttps://string-db.org/network/9606.ENSP00000415941Complement C4-B alpha chain; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins a [...]
SLC48A1 protein networkhttps://string-db.org/network/9606.ENSP00000415998Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
SLC35A2 protein networkhttps://string-db.org/network/9606.ENSP00000416002UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function; Belongs to the nucleotide-sugar transporter family. SLC35A subfa [...]
MICAL3 protein networkhttps://string-db.org/network/9606.ENSP00000416015[F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in [...]
PROB1 protein networkhttps://string-db.org/network/9606.ENSP00000416033Proline rich basic protein 1.
TMPRSS4 protein networkhttps://string-db.org/network/9606.ENSP00000416037Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity).
KIAA1549 protein networkhttps://string-db.org/network/9606.ENSP00000416040UPF0606 protein KIAA1549; KIAA1549; Belongs to the UPF0606 family.
TM2D2 protein networkhttps://string-db.org/network/9606.ENSP00000416050TM2 domain containing 2.
SERPINA1 protein networkhttps://string-db.org/network/9606.ENSP00000416066Short peptide from AAT; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin an [...]
GOLGA2 protein networkhttps://string-db.org/network/9606.ENSP00000416097Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether th [...]
ARHGEF38 protein networkhttps://string-db.org/network/9606.ENSP00000416125Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor.
PRAP1 protein networkhttps://string-db.org/network/9606.ENSP00000416126Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells.
TMEM238 protein networkhttps://string-db.org/network/9606.ENSP00000416154Transmembrane protein 238.
FKBP15 protein networkhttps://string-db.org/network/9606.ENSP00000416158FK506-binding protein 15; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes [...]
P2RX6 protein networkhttps://string-db.org/network/9606.ENSP00000416193P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.
GAGE12G protein networkhttps://string-db.org/network/9606.ENSP00000416249G antigen 12G.
EIF2B1 protein networkhttps://string-db.org/network/9606.ENSP00000416250Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP.
EIF4G1 protein networkhttps://string-db.org/network/9606.ENSP00000416255Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary [...]
DDX39B protein networkhttps://string-db.org/network/9606.ENSP00000416269Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and n [...]
WDR27 protein networkhttps://string-db.org/network/9606.ENSP00000416289WD repeat domain 27.
SLC2A1 protein networkhttps://string-db.org/network/9606.ENSP00000416293Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate spec [...]
TGFBI protein networkhttps://string-db.org/network/9606.ENSP00000416330Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity).
MFN2 protein networkhttps://string-db.org/network/9606.ENSP00000416338Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibri [...]
NELL2 protein networkhttps://string-db.org/network/9606.ENSP00000416341Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the con [...]
FBLIM1 protein networkhttps://string-db.org/network/9606.ENSP00000416387Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. [...]
SLC9A8 protein networkhttps://string-db.org/network/9606.ENSP00000416418Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...]
RPL32 protein networkhttps://string-db.org/network/9606.ENSP00000416429Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family.
ATP13A3 protein networkhttps://string-db.org/network/9606.ENSP00000416508ATPase 13A3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
FDXR protein networkhttps://string-db.org/network/9606.ENSP00000416515NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic [...]
SEMA4D protein networkhttps://string-db.org/network/9606.ENSP00000416523Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development o [...]
DDX46 protein networkhttps://string-db.org/network/9606.ENSP00000416534Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfam [...]
FBXO24 protein networkhttps://string-db.org/network/9606.ENSP00000416558F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
CFB protein networkhttps://string-db.org/network/9606.ENSP00000416561Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines [...]
DERA protein networkhttps://string-db.org/network/9606.ENSP00000416583Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Participates in stress granu [...]
FSHB protein networkhttps://string-db.org/network/9606.ENSP00000416606Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FS [...]
NME6 protein networkhttps://string-db.org/network/9606.ENSP00000416658Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...]
ZNF713 protein networkhttps://string-db.org/network/9606.ENSP00000416662Zinc finger protein 713; May be involved in transcriptional regulation.
PATL2 protein networkhttps://string-db.org/network/9606.ENSP00000416673Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor.
IGFALS protein networkhttps://string-db.org/network/9606.ENSP00000416683Insulin-like growth factor-binding protein complex acid labile subunit; Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.
RIC1 protein networkhttps://string-db.org/network/9606.ENSP00000416696RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required [...]
ACTBL2 protein networkhttps://string-db.org/network/9606.ENSP00000416706Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
XKR6 protein networkhttps://string-db.org/network/9606.ENSP00000416707XK-related protein 6; XK related 6; Belongs to the XK family.
RECQL protein networkhttps://string-db.org/network/9606.ENSP00000416739ATP-dependent DNA helicase Q1; DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-heli [...]
HS3ST6 protein networkhttps://string-db.org/network/9606.ENSP00000416741Heparan sulfate glucosamine 3-O-sulfotransferase 6; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrat [...]
STK33 protein networkhttps://string-db.org/network/9606.ENSP00000416750Serine/threonine-protein kinase 33; Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosph [...]
GALNT11 protein networkhttps://string-db.org/network/9606.ENSP00000416787Polypeptide N-acetylgalactosaminyltransferase 11; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymm [...]
CAMSAP3 protein networkhttps://string-db.org/network/9606.ENSP00000416797Calmodulin-regulated spectrin-associated protein 3; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...]
SPATA2 protein networkhttps://string-db.org/network/9606.ENSP00000416799Spermatogenesis-associated protein 2; Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding interm [...]
ZNF679 protein networkhttps://string-db.org/network/9606.ENSP00000416809Zinc finger protein 679; May be involved in transcriptional regulation.
ZC3H18 protein networkhttps://string-db.org/network/9606.ENSP00000416951Zinc finger CCCH-type containing 18.
TRA2B protein networkhttps://string-db.org/network/9606.ENSP00000416959Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively w [...]
ACKR2 protein networkhttps://string-db.org/network/9606.ENSP00000416996Atypical chemokine receptor 2; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...]
PLEKHM3 protein networkhttps://string-db.org/network/9606.ENSP00000417003Pleckstrin homology domain-containing family M member 3; Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation.
C19orf81 protein networkhttps://string-db.org/network/9606.ENSP00000417035Putative uncharacterized protein C19orf81; Chromosome 19 open reading frame 81.
PHACTR2 protein networkhttps://string-db.org/network/9606.ENSP00000417038Phosphatase and actin regulator 2.
B4E171_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000417050Tetraspanin.
EBP protein networkhttps://string-db.org/network/9606.ENSP000004170523-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family.
CFAP74 protein networkhttps://string-db.org/network/9606.ENSP00000417061Cilia- and flagella-associated protein 74; As part of the central apparatus of the cilium axoneme may play a role in cilium movement.
SPATA6L protein networkhttps://string-db.org/network/9606.ENSP00000417063Spermatogenesis associated 6 like; Belongs to the SPATA6 family.
DHX36 protein networkhttps://string-db.org/network/9606.ENSP00000417078ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene [...]
SLC15A2 protein networkhttps://string-db.org/network/9606.ENSP00000417085Solute carrier family 15 member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin ( [...]
DEFB121 protein networkhttps://string-db.org/network/9606.ENSP00000417128Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family.
BAP1 protein networkhttps://string-db.org/network/9606.ENSP00000417132Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB co [...]
PLTP protein networkhttps://string-db.org/network/9606.ENSP00000417138Phospholipid transfer protein; Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylgl [...]
NDUFA5 protein networkhttps://string-db.org/network/9606.ENSP00000417142NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
GPR143 protein networkhttps://string-db.org/network/9606.ENSP00000417161G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SE [...]
ATP6V1G3 protein networkhttps://string-db.org/network/9606.ENSP00000417171V-type proton ATPase subunit G 3; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...]
VAPB protein networkhttps://string-db.org/network/9606.ENSP00000417175Vesicle-associated membrane protein-associated protein B/C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium [...]
MUCL3 protein networkhttps://string-db.org/network/9606.ENSP00000417182Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth.
DUSP7 protein networkhttps://string-db.org/network/9606.ENSP00000417183Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays [...]
VWA1 protein networkhttps://string-db.org/network/9606.ENSP00000417185Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly.
ATPAF2 protein networkhttps://string-db.org/network/9606.ENSP00000417190ATP synthase mitochondrial F1 complex assembly factor 2; May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase); Belongs to the ATP12 family.
ZNF80 protein networkhttps://string-db.org/network/9606.ENSP00000417192Zinc finger protein 80; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PCBP4 protein networkhttps://string-db.org/network/9606.ENSP00000417196Poly(rC)-binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC.
HOXB3 protein networkhttps://string-db.org/network/9606.ENSP00000417207Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PARP15 protein networkhttps://string-db.org/network/9606.ENSP00000417214Protein mono-ADP-ribosyltransferase PARP15; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Acts as a negative regulator of transcription.
CPB1 protein networkhttps://string-db.org/network/9606.ENSP00000417222Carboxypeptidase B1; Belongs to the peptidase M14 family.
EIF2A protein networkhttps://string-db.org/network/9606.ENSP00000417229Eukaryotic translation initiation factor 2A, N-terminally processed; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methio [...]
MED12L protein networkhttps://string-db.org/network/9606.ENSP00000417235Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase [...]
GPR156 protein networkhttps://string-db.org/network/9606.ENSP00000417261Probable G-protein coupled receptor 156; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
NCK1 protein networkhttps://string-db.org/network/9606.ENSP00000417273Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2 [...]
NBPF6 protein networkhttps://string-db.org/network/9606.ENSP00000417277Neuroblastoma breakpoint family member 6; NBPF member 6.
CTAGE8 protein networkhttps://string-db.org/network/9606.ENSP00000417289CTAGE family member 8.
REPIN1 protein networkhttps://string-db.org/network/9606.ENSP00000417291Replication initiator 1; Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'- ATT-3' reiterated sequences downstream of the o [...]
KLF8 protein networkhttps://string-db.org/network/9606.ENSP00000417303Krueppel-like factor 8; Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) ph [...]
KRTAP5-7 protein networkhttps://string-db.org/network/9606.ENSP00000417330Keratin-associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
ROBO2 protein networkhttps://string-db.org/network/9606.ENSP00000417335Roundabout homolog 2; Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the n [...]
GOLIM4 protein networkhttps://string-db.org/network/9606.ENSP00000417354Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi.
ATP6V1F protein networkhttps://string-db.org/network/9606.ENSP00000417378V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracell [...]
HELZ2 protein networkhttps://string-db.org/network/9606.ENSP00000417401Helicase with zinc finger domain 2; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA; Belongs to the DNA2/NAM7 hel [...]
PUS7 protein networkhttps://string-db.org/network/9606.ENSP00000417402Pseudouridylate synthase 7 homolog; Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylat [...]
HFE protein networkhttps://string-db.org/network/9606.ENSP00000417404Hereditary hemochromatosis protein; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
DNAJB8 protein networkhttps://string-db.org/network/9606.ENSP00000417418DnaJ homolog subfamily B member 8; Efficient suppressor of aggregation and toxicity of disease- associated polyglutamine proteins.
RBMXL3 protein networkhttps://string-db.org/network/9606.ENSP00000417451RNA-binding motif protein, X-linked-like-3; RBMX like 3.
RRP1 protein networkhttps://string-db.org/network/9606.ENSP00000417464Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA. Belongs to the RRP1 family.
ZNF786 protein networkhttps://string-db.org/network/9606.ENSP00000417470Zinc finger protein 786; May be involved in transcriptional regulation.
FSD1L protein networkhttps://string-db.org/network/9606.ENSP00000417492FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like.
MUC4 protein networkhttps://string-db.org/network/9606.ENSP00000417498Mucin-4 alpha chain; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. [...]
SUPT20H protein networkhttps://string-db.org/network/9606.ENSP00000417510Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulati [...]
H0Y858_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000417517Uncharacterized protein.
DNAJC24 protein networkhttps://string-db.org/network/9606.ENSP00000417548DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function [...]
H7C4K7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000417556Uncharacterized protein.
NMD3 protein networkhttps://string-db.org/network/9606.ENSP0000041755960S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
STIM2 protein networkhttps://string-db.org/network/9606.ENSP00000417569Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive C [...]
YIPF6 protein networkhttps://string-db.org/network/9606.ENSP00000417573Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression.
IAH1 protein networkhttps://string-db.org/network/9606.ENSP00000417580Isoamyl acetate-hydrolyzing esterase 1 homolog; Probable lipase; Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
FAM199X protein networkhttps://string-db.org/network/9606.ENSP00000417581Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family.
ST6GALNAC5 protein networkhttps://string-db.org/network/9606.ENSP00000417583Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By s [...]
FBXL2 protein networkhttps://string-db.org/network/9606.ENSP00000417601F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitina [...]
MRPL47 protein networkhttps://string-db.org/network/9606.ENSP00000417602Mitochondrial ribosomal protein L47; Belongs to the universal ribosomal protein uL29 family.
RAB23 protein networkhttps://string-db.org/network/9606.ENSP00000417610Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
TMEM176A protein networkhttps://string-db.org/network/9606.ENSP00000417626Transmembrane protein 176A.
ANKUB1 protein networkhttps://string-db.org/network/9606.ENSP00000417635Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1.
DBNL protein networkhttps://string-db.org/network/9606.ENSP00000417653Drebrin-like protein; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formati [...]
SLC35A5 protein networkhttps://string-db.org/network/9606.ENSP00000417654Probable UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5.
PPM1L protein networkhttps://string-db.org/network/9606.ENSP00000417659Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK [...]
ZBTB8OS protein networkhttps://string-db.org/network/9606.ENSP00000417677Protein archease; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation [...]
SLBP protein networkhttps://string-db.org/network/9606.ENSP00000417686Histone RNA hairpin-binding protein; RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to e [...]
ZNF525 protein networkhttps://string-db.org/network/9606.ENSP00000417696Zinc finger protein 525.
DCUN1D2 protein networkhttps://string-db.org/network/9606.ENSP00000417706DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an [...]
DPPA2 protein networkhttps://string-db.org/network/9606.ENSP00000417710Developmental pluripotency-associated protein 2; Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status [...]
FAM205A protein networkhttps://string-db.org/network/9606.ENSP00000417711Protein FAM205A; Family with sequence similarity 205 member A.
DDI2 protein networkhttps://string-db.org/network/9606.ENSP00000417748Protein DDI1 homolog 2; Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination [...]
NAA10 protein networkhttps://string-db.org/network/9606.ENSP00000417763N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that ar [...]
ALG2 protein networkhttps://string-db.org/network/9606.ENSP00000417764Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate; Belongs to the gly [...]
IQUB protein networkhttps://string-db.org/network/9606.ENSP00000417769IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance.
SMIM4 protein networkhttps://string-db.org/network/9606.ENSP00000417806Small integral membrane protein 4.
EFCAB10 protein networkhttps://string-db.org/network/9606.ENSP00000417841EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10.
ANP32A protein networkhttps://string-db.org/network/9606.ENSP00000417864Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent a [...]
PAEP protein networkhttps://string-db.org/network/9606.ENSP00000417898Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in [...]
GPHN protein networkhttps://string-db.org/network/9606.ENSP00000417901Molybdopterin molybdenumtransferase; Microtubule-associated protein involved in membrane protein- cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subs [...]
ASB11 protein networkhttps://string-db.org/network/9606.ENSP00000417914Ankyrin repeat and SOCS box protein 11; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
TSPYL6 protein networkhttps://string-db.org/network/9606.ENSP00000417919Testis-specific Y-encoded-like protein 6; TSPY like 6; Belongs to the nucleosome assembly protein (NAP) family.
VWA3B protein networkhttps://string-db.org/network/9606.ENSP00000417955Von Willebrand factor A domain containing 3B.
CCDC39 protein networkhttps://string-db.org/network/9606.ENSP00000417960Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby [...]
PPP2R5D protein networkhttps://string-db.org/network/9606.ENSP00000417963Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...]
EHMT1 protein networkhttps://string-db.org/network/9606.ENSP00000417980Histone-lysine N-methyltransferase EHMT1; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me repre [...]
GK5 protein networkhttps://string-db.org/network/9606.ENSP00000418001Glycerol kinase 5.
MRPS22 protein networkhttps://string-db.org/network/9606.ENSP00000418008Mitochondrial ribosomal protein S22.
RARRES2 protein networkhttps://string-db.org/network/9606.ENSP00000418009Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CM [...]
IFNE protein networkhttps://string-db.org/network/9606.ENSP00000418018Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Di [...]
IRF5 protein networkhttps://string-db.org/network/9606.ENSP00000418037Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling; B [...]
NECTIN3 protein networkhttps://string-db.org/network/9606.ENSP00000418070Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. [...]
CACNA2D2 protein networkhttps://string-db.org/network/9606.ENSP00000418081Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...]
RPL37A protein networkhttps://string-db.org/network/9606.ENSP00000418082Ribosomal protein L37a.
C3orf14 protein networkhttps://string-db.org/network/9606.ENSP00000418086Uncharacterized protein C3orf14; Chromosome 3 open reading frame 14.
SLC45A1 protein networkhttps://string-db.org/network/9606.ENSP00000418096Proton-associated sugar transporter A; Proton-associated glucose transporter in the brain. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
PTPRG protein networkhttps://string-db.org/network/9606.ENSP00000418112Receptor-type tyrosine-protein phosphatase gamma; Possesses tyrosine phosphatase activity.
SPRR2F protein networkhttps://string-db.org/network/9606.ENSP00000418193Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...]
PARP14 protein networkhttps://string-db.org/network/9606.ENSP00000418194Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to [...]
RPL7L1 protein networkhttps://string-db.org/network/9606.ENSP00000418221Ribosomal protein L7 like 1.
NISCH protein networkhttps://string-db.org/network/9606.ENSP00000418232Nischarin; Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiati [...]
ZFP57 protein networkhttps://string-db.org/network/9606.ENSP00000418259Zinc finger protein 57 homolog; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific [...]
MCM10 protein networkhttps://string-db.org/network/9606.ENSP00000418268Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Addition [...]
CIAO1 protein networkhttps://string-db.org/network/9606.ENSP00000418287Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of [...]
CMC1 protein networkhttps://string-db.org/network/9606.ENSP00000418348COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome [...]
TAF1L protein networkhttps://string-db.org/network/9606.ENSP00000418379Transcription initiation factor TFIID subunit 1-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. Belongs to the [...]
SRPRB protein networkhttps://string-db.org/network/9606.ENSP00000418401Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting [...]
NDUFA3 protein networkhttps://string-db.org/network/9606.ENSP00000418438NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
PPP2CA protein networkhttps://string-db.org/network/9606.ENSP00000418447Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase [...]
LCN10 protein networkhttps://string-db.org/network/9606.ENSP00000418491Epididymal-specific lipocalin-10; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
MME protein networkhttps://string-db.org/network/9606.ENSP00000418525Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and L [...]
NSFL1C protein networkhttps://string-db.org/network/9606.ENSP00000418529NSFL1 cofactor p47; Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP- mediated reassembly of Golgi stacks after mitos [...]
UGT1A3 protein networkhttps://string-db.org/network/9606.ENSP00000418532UDP-glucuronosyltransferase 1-3; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...]
U2SURP protein networkhttps://string-db.org/network/9606.ENSP00000418563U2 snRNP-associated SURP motif-containing protein; U2 snRNP associated SURP domain containing; Belongs to the splicing factor SR family.
VAMP2 protein networkhttps://string-db.org/network/9606.ENSP00000418572Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltag [...]
TAFA1 protein networkhttps://string-db.org/network/9606.ENSP00000418575Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation. Belongs to the TAFA family.
FHIT protein networkhttps://string-db.org/network/9606.ENSP00000418582Bis(5'-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremel [...]
SNX21 protein networkhttps://string-db.org/network/9606.ENSP00000418593Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular traff [...]
KRBA1 protein networkhttps://string-db.org/network/9606.ENSP00000418647Protein KRBA1; KRAB-A domain containing 1.
UBN2 protein networkhttps://string-db.org/network/9606.ENSP00000418648Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family.
C21orf62 protein networkhttps://string-db.org/network/9606.ENSP00000418653Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62.
PTRH1 protein networkhttps://string-db.org/network/9606.ENSP00000418661peptidyl-tRNA hydrolase 1 homolog; Belongs to the PTH family.
CAVIN4 protein networkhttps://string-db.org/network/9606.ENSP00000418668Caveolae-associated protein 4; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within [...]
SEPHS2 protein networkhttps://string-db.org/network/9606.ENSP00000418669Selenide, water dikinase 2; Synthesizes selenophosphate from selenide and ATP; Belongs to the selenophosphate synthase 1 family. Class I subfamily.
RWDD2B protein networkhttps://string-db.org/network/9606.ENSP00000418693RWD domain containing 2B.
PSMD6 protein networkhttps://string-db.org/network/9606.ENSP0000041869526S proteasome non-ATPase regulatory subunit 6; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...]
ZNF273 protein networkhttps://string-db.org/network/9606.ENSP00000418719Zinc finger protein 273; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PURG protein networkhttps://string-db.org/network/9606.ENSP00000418721Purine-rich element-binding protein gamma; Purine rich element binding protein G.
MYSM1 protein networkhttps://string-db.org/network/9606.ENSP00000418734Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a co [...]
ADAMTS9 protein networkhttps://string-db.org/network/9606.ENSP00000418735A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-14 [...]
ESRP2 protein networkhttps://string-db.org/network/9606.ENSP00000418748Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelia [...]
BTBD9 protein networkhttps://string-db.org/network/9606.ENSP00000418751BTB/POZ domain-containing protein 9; BTB domain containing 9.
PTK7 protein networkhttps://string-db.org/network/9606.ENSP00000418754Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the [...]
TREML2 protein networkhttps://string-db.org/network/9606.ENSP00000418767Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells e [...]
TIMMDC1 protein networkhttps://string-db.org/network/9606.ENSP00000418803Complex I assembly factor TIMMDC1, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing [...]
SELENOK protein networkhttps://string-db.org/network/9606.ENSP00000418813Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associ [...]
FTO protein networkhttps://string-db.org/network/9606.ENSP00000418823Alpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass [...]
ENSP00000418875 protein networkhttps://string-db.org/network/9606.ENSP00000418875Probable threonine protease PRSS50.
SELENOT protein networkhttps://string-db.org/network/9606.ENSP00000418910Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell [...]
CDKN2A protein networkhttps://string-db.org/network/9606.ENSP00000418915Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cy [...]
PEG10 protein networkhttps://string-db.org/network/9606.ENSP00000418944Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth prom [...]
BRCA1 protein networkhttps://string-db.org/network/9606.ENSP00000418960Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by [...]
BNIP5 protein networkhttps://string-db.org/network/9606.ENSP00000418983BCL2 interacting protein 5.
SYNPR protein networkhttps://string-db.org/network/9606.ENSP00000418994Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family.
LSAMP protein networkhttps://string-db.org/network/9606.ENSP00000419000Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic s [...]
UTP25 protein networkhttps://string-db.org/network/9606.ENSP00000419005Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs.
PCCB protein networkhttps://string-db.org/network/9606.ENSP00000419027Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of od [...]
BRAF protein networkhttps://string-db.org/network/9606.ENSP00000419060Serine/threonine-protein kinase B-raf; Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activa [...]
CALML4 protein networkhttps://string-db.org/network/9606.ENSP00000419081Calmodulin-like protein 4; Calmodulin like 4; Belongs to the calmodulin family.
TIGIT protein networkhttps://string-db.org/network/9606.ENSP00000419085T-cell immunoreceptor with Ig and ITIM domains; Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses [...]
NDUFB2 protein networkhttps://string-db.org/network/9606.ENSP00000419087NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...]
FAM162A protein networkhttps://string-db.org/network/9606.ENSP00000419088Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells [...]
CACNA2D3 protein networkhttps://string-db.org/network/9606.ENSP00000419101Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...]
OR10C1 protein networkhttps://string-db.org/network/9606.ENSP00000419119Olfactory receptor 10C1; Odorant receptor.
FAM107A protein networkhttps://string-db.org/network/9606.ENSP00000419124Actin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polyme [...]
C10orf88 protein networkhttps://string-db.org/network/9606.ENSP00000419126ATPase PAAT; ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maint [...]
ZBTB20 protein networkhttps://string-db.org/network/9606.ENSP00000419153Zinc finger and BTB domain-containing protein 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may [...]
SPATA45 protein networkhttps://string-db.org/network/9606.ENSP00000419160Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family.
WDR86 protein networkhttps://string-db.org/network/9606.ENSP00000419162WD repeat domain 86.
SMYD3 protein networkhttps://string-db.org/network/9606.ENSP00000419184Histone-lysine N-methyltransferase SMYD3; Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys [...]
ONECUT2 protein networkhttps://string-db.org/network/9606.ENSP00000419185One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; Belongs to the CUT homeobox family.
MSMP protein networkhttps://string-db.org/network/9606.ENSP00000419194Prostate-associated microseminoprotein; Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization [...]
CAMKV protein networkhttps://string-db.org/network/9606.ENSP00000419195CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
ASB14 protein networkhttps://string-db.org/network/9606.ENSP00000419199Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...]
TCAF1 protein networkhttps://string-db.org/network/9606.ENSP00000419235TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell [...]
FXN protein networkhttps://string-db.org/network/9606.ENSP00000419243Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the p [...]
RIIAD1 protein networkhttps://string-db.org/network/9606.ENSP00000419249RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1.
PIK3CG protein networkhttps://string-db.org/network/9606.ENSP00000419260Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to gener [...]
EVX1 protein networkhttps://string-db.org/network/9606.ENSP00000419266Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types.
PRKRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000419270PRKR-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).
TTC26 protein networkhttps://string-db.org/network/9606.ENSP00000419279Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary [...]
POU5F1B protein networkhttps://string-db.org/network/9606.ENSP00000419298Putative POU domain, class 5, transcription factor 1B; Shows weak transcriptional activator activity.
TRPC1 protein networkhttps://string-db.org/network/9606.ENSP00000419313Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...]
SUCLG2 protein networkhttps://string-db.org/network/9606.ENSP00000419325Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synt [...]
ADCY5 protein networkhttps://string-db.org/network/9606.ENSP00000419361Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosol [...]
MALSU1 protein networkhttps://string-db.org/network/9606.ENSP00000419370Mitochondrial assembly of ribosomal large subunit protein 1; Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventin [...]
AZI2 protein networkhttps://string-db.org/network/9606.ENSP000004193715-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligome [...]
ZNF717 protein networkhttps://string-db.org/network/9606.ENSP00000419377Zinc finger protein 717; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CLIC3 protein networkhttps://string-db.org/network/9606.ENSP00000419378Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family.
CDNF protein networkhttps://string-db.org/network/9606.ENSP00000419395Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-l [...]
ZNF782 protein networkhttps://string-db.org/network/9606.ENSP00000419397Zinc finger protein 782; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GCNT2 protein networkhttps://string-db.org/network/9606.ENSP00000419411N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N- acetyllactosaminoglycans. Introduces the blood group I antigen during [...]
SLC4A2 protein networkhttps://string-db.org/network/9606.ENSP00000419412Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution.
ARMC8 protein networkhttps://string-db.org/network/9606.ENSP00000419413Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasom [...]
C1orf52 protein networkhttps://string-db.org/network/9606.ENSP00000419417UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family.
PPIA protein networkhttps://string-db.org/network/9606.ENSP00000419425Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptide [...]
ADAM9 protein networkhttps://string-db.org/network/9606.ENSP00000419446Disintegrin and metalloproteinase domain-containing protein 9; Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VC [...]
EIF1 protein networkhttps://string-db.org/network/9606.ENSP00000419449Eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of [...]
RNF183 protein networkhttps://string-db.org/network/9606.ENSP00000419454E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER [...]
NOBOX protein networkhttps://string-db.org/network/9606.ENSP00000419457Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'.
WWTR1 protein networkhttps://string-db.org/network/9606.ENSP00000419465WW domain-containing transcription regulator protein 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ [...]
COMMD2 protein networkhttps://string-db.org/network/9606.ENSP00000419475COMM domain-containing protein 2; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF- kappa-B.
GCSAM protein networkhttps://string-db.org/network/9606.ENSP00000419485Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive re [...]
RYBP protein networkhttps://string-db.org/network/9606.ENSP00000419494RING1 and YY1-binding protein; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, inclu [...]
HACD4 protein networkhttps://string-db.org/network/9606.ENSP00000419503Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, [...]
GIMAP4 protein networkhttps://string-db.org/network/9606.ENSP00000419545GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis (By similarity). GTPase which exhibits a higher affinity for GDP than for GTP.
DPH3 protein networkhttps://string-db.org/network/9606.ENSP00000419599DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosyla [...]
ARL6 protein networkhttps://string-db.org/network/9606.ENSP00000419619ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would [...]
NUDT5 protein networkhttps://string-db.org/network/9606.ENSP00000419628ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosph [...]
TTC12 protein networkhttps://string-db.org/network/9606.ENSP00000419652Tetratricopeptide repeat domain 12.
DENND2A protein networkhttps://string-db.org/network/9606.ENSP00000419654DENN domain-containing protein 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...]
SSBP1 protein networkhttps://string-db.org/network/9606.ENSP00000419665Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitoc [...]
RXRA protein networkhttps://string-db.org/network/9606.ENSP00000419692Retinoic acid receptor RXR-alpha; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elem [...]
KNCN protein networkhttps://string-db.org/network/9606.ENSP00000419705Kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking.
MYMK protein networkhttps://string-db.org/network/9606.ENSP00000419712Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion react [...]
NSUN4 protein networkhttps://string-db.org/network/9606.ENSP000004197405-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subun [...]
BRD9 protein networkhttps://string-db.org/network/9606.ENSP00000419765Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that [...]
CDK5 protein networkhttps://string-db.org/network/9606.ENSP00000419782Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuron [...]
RTL9 protein networkhttps://string-db.org/network/9606.ENSP00000419786Retrotransposon Gag like 9.
KLHL13 protein networkhttps://string-db.org/network/9606.ENSP00000419803Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin [...]
KIAA2012 protein networkhttps://string-db.org/network/9606.ENSP00000419834Uncharacterized protein KIAA2012; KIAA2012.
GMPS protein networkhttps://string-db.org/network/9606.ENSP00000419851GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a [...]
CDS2 protein networkhttps://string-db.org/network/9606.ENSP00000419879Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.
RAD51B protein networkhttps://string-db.org/network/9606.ENSP00000419881DNA repair protein RAD51 homolog 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. M [...]
L1TD1 protein networkhttps://string-db.org/network/9606.ENSP00000419901LINE1 type transposase domain containing 1.
KLF6 protein networkhttps://string-db.org/network/9606.ENSP00000419923Krueppel-like factor 6; Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
PXT1 protein networkhttps://string-db.org/network/9606.ENSP00000419944Peroxisomal testis enriched protein 1.
ERVW-1 protein networkhttps://string-db.org/network/9606.ENSP00000419945Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during pl [...]
KCNAB1 protein networkhttps://string-db.org/network/9606.ENSP00000419952Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its [...]
POR protein networkhttps://string-db.org/network/9606.ENSP00000419970NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome [...]
PEX5L protein networkhttps://string-db.org/network/9606.ENSP00000419975PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs t [...]
HOXB6 protein networkhttps://string-db.org/network/9606.ENSP00000420009Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PIGP protein networkhttps://string-db.org/network/9606.ENSP00000420037Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...]
KCNIP2 protein networkhttps://string-db.org/network/9606.ENSP00000420040Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate o [...]
ABHD14B protein networkhttps://string-db.org/network/9606.ENSP00000420065Protein ABHD14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription.
SERP1 protein networkhttps://string-db.org/network/9606.ENSP00000420076Stress-associated endoplasmic reticulum protein 1; Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against [...]
SLITRK3 protein networkhttps://string-db.org/network/9606.ENSP00000420091SLIT and NTRK-like protein 3; Suppresses neurite outgrowth.
RAB9A protein networkhttps://string-db.org/network/9606.ENSP00000420127Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the pr [...]
PLSCR2 protein networkhttps://string-db.org/network/9606.ENSP00000420132Phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...]
B4GALT4 protein networkhttps://string-db.org/network/9606.ENSP00000420161Beta-1,4-galactosyltransferase 4; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the [...]
GSTA2 protein networkhttps://string-db.org/network/9606.ENSP00000420168Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family.
ERVFRD-1 protein networkhttps://string-db.org/network/9606.ENSP00000420174Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during pl [...]
POLE4 protein networkhttps://string-db.org/network/9606.ENSP00000420176DNA polymerase epsilon subunit 4; Accessory component of the DNA polymerase epsilon complex. Participates in DNA repair and in chromosomal DNA replication (By similarity).
CCDC14 protein networkhttps://string-db.org/network/9606.ENSP00000420180Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization.
IQCJ-SCHIP1 protein networkhttps://string-db.org/network/9606.ENSP00000420182IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial [...]
CASR protein networkhttps://string-db.org/network/9606.ENSP00000420194Extracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. [...]
SRSF10 protein networkhttps://string-db.org/network/9606.ENSP00000420195Serine/arginine-rich splicing factor 10; Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recogni [...]
ADPRH protein networkhttps://string-db.org/network/9606.ENSP00000420200[Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.
RGL2 protein networkhttps://string-db.org/network/9606.ENSP00000420211Ral guanine nucleotide dissociation stimulator-like 2; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in [...]
FLNB protein networkhttps://string-db.org/network/9606.ENSP00000420213Filamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various [...]
CPA5 protein networkhttps://string-db.org/network/9606.ENSP00000420237Carboxypeptidase A5; Belongs to the peptidase M14 family.
CYLC2 protein networkhttps://string-db.org/network/9606.ENSP00000420256Cylicin-2; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.
NR6A1 protein networkhttps://string-db.org/network/9606.ENSP00000420267Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression i [...]
ADH7 protein networkhttps://string-db.org/network/9606.ENSP00000420269All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially al [...]
UHMK1 protein networkhttps://string-db.org/network/9606.ENSP00000420270Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved i [...]
PHC3 protein networkhttps://string-db.org/network/9606.ENSP00000420294Polyhomeotic-like protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
PDE6B protein networkhttps://string-db.org/network/9606.ENSP00000420295Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a func [...]
CD200 protein networkhttps://string-db.org/network/9606.ENSP00000420298OX-2 membrane glycoprotein; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
THOC5 protein networkhttps://string-db.org/network/9606.ENSP00000420306THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically ass [...]
RPL23 protein networkhttps://string-db.org/network/9606.ENSP00000420311Ribosomal protein L23.
ROBO1 protein networkhttps://string-db.org/network/9606.ENSP00000420321Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neu [...]
RWDD1 protein networkhttps://string-db.org/network/9606.ENSP00000420357RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family.
CST7 protein networkhttps://string-db.org/network/9606.ENSP00000420384Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
ATP11A protein networkhttps://string-db.org/network/9606.ENSP00000420387Probable phospholipid-transporting ATPase IH; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...]
ZNF398 protein networkhttps://string-db.org/network/9606.ENSP00000420418Zinc finger protein 398; Functions as a transcriptional activator.
CNIH4 protein networkhttps://string-db.org/network/9606.ENSP00000420443Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory [...]
MGAM2 protein networkhttps://string-db.org/network/9606.ENSP00000420449Maltase-glucoamylase 2.
RNF182 protein networkhttps://string-db.org/network/9606.ENSP00000420465E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role i [...]
NACAD protein networkhttps://string-db.org/network/9606.ENSP00000420477NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge f [...]
OARD1 protein networkhttps://string-db.org/network/9606.ENSP00000420484ADP-ribose glycohydrolase OARD1; ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Sp [...]
TFR2 protein networkhttps://string-db.org/network/9606.ENSP00000420525Transferrin receptor protein 2; Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differe [...]
TFAM protein networkhttps://string-db.org/network/9606.ENSP00000420588Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initi [...]
EMC1 protein networkhttps://string-db.org/network/9606.ENSP00000420608ER membrane protein complex subunit 1; Belongs to the EMC1 family.
C6orf201 protein networkhttps://string-db.org/network/9606.ENSP00000420610Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201.
TIPARP protein networkhttps://string-db.org/network/9606.ENSP00000420612Protein mono-ADP-ribosyltransferase TIPARP; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulat [...]
TFDP2 protein networkhttps://string-db.org/network/9606.ENSP00000420616Transcription factor Dp-2; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter reg [...]
MFN1 protein networkhttps://string-db.org/network/9606.ENSP00000420617Mitofusin-1; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coile [...]
SSR3 protein networkhttps://string-db.org/network/9606.ENSP00000420641Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; B [...]
TMEM14B protein networkhttps://string-db.org/network/9606.ENSP00000420658Transmembrane protein 14B; Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation [...]
KLHL29 protein networkhttps://string-db.org/network/9606.ENSP00000420659Kelch-like protein 29; Kelch like family member 29.
QTRT2 protein networkhttps://string-db.org/network/9606.ENSP00000420682Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) [...]
PLCXD2 protein networkhttps://string-db.org/network/9606.ENSP00000420686PI-PLC X domain-containing protein 2; Phosphatidylinositol specific phospholipase C X domain containing 2.
MRPS14 protein networkhttps://string-db.org/network/9606.ENSP00000420714Mitochondrial ribosomal protein S14.
ARMH1 protein networkhttps://string-db.org/network/9606.ENSP00000420716Armadillo like helical domain containing 1.
KRTAP5-8 protein networkhttps://string-db.org/network/9606.ENSP00000420723Keratin-associated protein 5-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which a [...]
ZNF181 protein networkhttps://string-db.org/network/9606.ENSP00000420727Zinc finger protein 181; May be involved in transcriptional regulation.
PRB1 protein networkhttps://string-db.org/network/9606.ENSP00000420826Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1.
PCDHA1 protein networkhttps://string-db.org/network/9606.ENSP00000420840Protocadherin alpha-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
NIM1K protein networkhttps://string-db.org/network/9606.ENSP00000420849NIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
EFCAB12 protein networkhttps://string-db.org/network/9606.ENSP00000420854EF-hand calcium-binding domain-containing protein 12; EF-hand calcium binding domain 12.
PRIMPOL protein networkhttps://string-db.org/network/9606.ENSP00000420860DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear repli [...]
RMND5B protein networkhttps://string-db.org/network/9606.ENSP00000420875E3 ubiquitin-protein transferase RMND5B; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent pr [...]
TMEM150C protein networkhttps://string-db.org/network/9606.ENSP00000420919Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs [...]
PDK2 protein networkhttps://string-db.org/network/9606.ENSP00000420927[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphoryla [...]
HERC3-2 protein networkhttps://string-db.org/network/9606.ENSP00000421021Probable E3 ubiquitin-protein ligase HERC3.
SPINK13 protein networkhttps://string-db.org/network/9606.ENSP00000421048Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from [...]
ATP5MGL protein networkhttps://string-db.org/network/9606.ENSP00000421076Putative ATP synthase subunit g 2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the me [...]
FAM90A26 protein networkhttps://string-db.org/network/9606.ENSP00000421131Putative protein FAM90A26; Family with sequence similarity 90 member A26; Belongs to the FAM90 family.
BEND4 protein networkhttps://string-db.org/network/9606.ENSP00000421169BEN domain containing 4.
AWAT2 protein networkhttps://string-db.org/network/9606.ENSP00000421172Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters. Shows a preference for mediu [...]
MAML3 protein networkhttps://string-db.org/network/9606.ENSP00000421180Mastermind-like protein 3; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Belongs to the mastermind family.
MGAT4D protein networkhttps://string-db.org/network/9606.ENSP00000421185Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surf [...]
IGSF22 protein networkhttps://string-db.org/network/9606.ENSP00000421191Immunoglobulin superfamily member 22.
ZNF154 protein networkhttps://string-db.org/network/9606.ENSP00000421258Zinc finger protein 154; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SLC10A7 protein networkhttps://string-db.org/network/9606.ENSP00000421275Sodium/bile acid cotransporter 7; Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins, to produce a prope [...]
MYO10 protein networkhttps://string-db.org/network/9606.ENSP00000421280Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles an [...]
SH3D21 protein networkhttps://string-db.org/network/9606.ENSP00000421294SH3 domain containing 21.
K7N7A8_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000421315DUF4205 domain-containing protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
ATP2C1 protein networkhttps://string-db.org/network/9606.ENSP00000421326Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium; Belongs to the cation transport ATPase (P- [...]
SLCO6A1 protein networkhttps://string-db.org/network/9606.ENSP00000421339Solute carrier organic anion transporter family member 6A1.
PIEZO2 protein networkhttps://string-db.org/network/9606.ENSP00000421377Piezo-type mechanosensitive ion channel component 2; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotr [...]
SNF8 protein networkhttps://string-db.org/network/9606.ENSP00000421380Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal [...]
ROPN1L protein networkhttps://string-db.org/network/9606.ENSP00000421405Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermato [...]
TIGD5 protein networkhttps://string-db.org/network/9606.ENSP00000421489Tigger transposable element derived 5.
XRCC4 protein networkhttps://string-db.org/network/9606.ENSP00000421491DNA repair protein XRCC4; Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRC [...]
PCBD2 protein networkhttps://string-db.org/network/9606.ENSP00000421544Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By simila [...]
GPR33 protein networkhttps://string-db.org/network/9606.ENSP00000421557Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family.
XPNPEP1 protein networkhttps://string-db.org/network/9606.ENSP00000421566Xaa-Pro aminopeptidase 1; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro.
GOLGA6L4 protein networkhttps://string-db.org/network/9606.ENSP00000421586Golgin subfamily A member 6-like protein 4; Golgin A6 family like 4; Belongs to the GOLGA6 family.
ALYREF protein networkhttps://string-db.org/network/9606.ENSP00000421592THO complex subunit 4; Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pat [...]
SPDYE2 protein networkhttps://string-db.org/network/9606.ENSP00000421686Speedy protein E2; speedy/RINGO cell cycle regulator family member E2; Belongs to the Speedy/Ringo family.
GNGT2 protein networkhttps://string-db.org/network/9606.ENSP00000421710Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...]
GC protein networkhttps://string-db.org/network/9606.ENSP00000421725Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation an [...]
CR1L protein networkhttps://string-db.org/network/9606.ENSP00000421736Complement component receptor 1-like protein; Complement C3b/C4b receptor 1 like; Belongs to the receptors of complement activation (RCA) family.
D6RAR5_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000421799Homeobox domain-containing protein.
HGFAC protein networkhttps://string-db.org/network/9606.ENSP00000421801Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family.
ANAPC13 protein networkhttps://string-db.org/network/9606.ENSP00000421842Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
RANBP3L protein networkhttps://string-db.org/network/9606.ENSP00000421853Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocki [...]
MAGED4B protein networkhttps://string-db.org/network/9606.ENSP00000421861Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...]
ZNF827 protein networkhttps://string-db.org/network/9606.ENSP00000421863Zinc finger protein 827; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CCDC169-SOHLH2 protein networkhttps://string-db.org/network/9606.ENSP00000421868CCDC169-SOHLH2 readthrough.
DCANP1 protein networkhttps://string-db.org/network/9606.ENSP00000421871Dendritic cell nuclear protein 1; Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.
ZNF672 protein networkhttps://string-db.org/network/9606.ENSP00000421915Zinc finger protein 672; May be involved in transcriptional regulation.
HMGXB3 protein networkhttps://string-db.org/network/9606.ENSP00000421917HMG-box containing 3.
UIMC1 protein networkhttps://string-db.org/network/9606.ENSP00000421926BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin (Ref.37). Plays a central role in the BRCA1-A complex by specifically binding [...]
PRRC1 protein networkhttps://string-db.org/network/9606.ENSP00000421965Protein PRRC1; Proline rich coiled-coil 1.
PAQR3 protein networkhttps://string-db.org/network/9606.ENSP00000421981Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Belongs to the ADIPOR family.
FNIP1 protein networkhttps://string-db.org/network/9606.ENSP00000421985Folliculin-interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client pr [...]
ACTN3 protein networkhttps://string-db.org/network/9606.ENSP00000422007Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
NFXL1 protein networkhttps://string-db.org/network/9606.ENSP00000422037NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1.
FAM47E-STBD1 protein networkhttps://string-db.org/network/9606.ENSP00000422067FAM47E-STBD1 readthrough.
USP17L25 protein networkhttps://string-db.org/network/9606.ENSP00000422097Ubiquitin carboxyl-terminal hydrolase 17-like protein 24; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
FAM193B protein networkhttps://string-db.org/network/9606.ENSP00000422131Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family.
CAST protein networkhttps://string-db.org/network/9606.ENSP00000422176Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein deg [...]
SORCS2 protein networkhttps://string-db.org/network/9606.ENSP00000422185VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding bot [...]
TTC23L protein networkhttps://string-db.org/network/9606.ENSP00000422188Tetratricopeptide repeat domain 23 like.
USP17L21 protein networkhttps://string-db.org/network/9606.ENSP00000422216Ubiquitin carboxyl-terminal hydrolase 17-like protein 21; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
ATPSCKMT protein networkhttps://string-db.org/network/9606.ENSP00000422338ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for [...]
GSTCD protein networkhttps://string-db.org/network/9606.ENSP00000422354Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family.
NUDT16 protein networkhttps://string-db.org/network/9606.ENSP00000422375U8 snoRNA-decapping enzyme; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that [...]
TMEM158 protein networkhttps://string-db.org/network/9606.ENSP00000422431Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide.
RPS6KA2 protein networkhttps://string-db.org/network/9606.ENSP00000422435Ribosomal protein S6 kinase alpha-2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of tran [...]
PDGFC protein networkhttps://string-db.org/network/9606.ENSP00000422464Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and ch [...]
TMEM33 protein networkhttps://string-db.org/network/9606.ENSP00000422473Transmembrane protein 33; Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and [...]
TTC39B protein networkhttps://string-db.org/network/9606.ENSP00000422496Tetratricopeptide repeat protein 39B; Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR [...]
ADGRL3 protein networkhttps://string-db.org/network/9606.ENSP00000422533Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays [...]
ADAMTS12 protein networkhttps://string-db.org/network/9606.ENSP00000422554A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti- tumo [...]
TRIML2 protein networkhttps://string-db.org/network/9606.ENSP00000422581Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2.
SLIT2 protein networkhttps://string-db.org/network/9606.ENSP00000422591Slit homolog 2 protein C-product; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neur [...]
ACSL1 protein networkhttps://string-db.org/network/9606.ENSP00000422607Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. P [...]
USP17L17 protein networkhttps://string-db.org/network/9606.ENSP00000422621Ubiquitin carboxyl-terminal hydrolase 17-like protein 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
LARP7 protein networkhttps://string-db.org/network/9606.ENSP00000422626La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b [...]
INPP4B protein networkhttps://string-db.org/network/9606.ENSP00000422793Inositol polyphosphate 4-phosphatase type II; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphos [...]
FRAS1 protein networkhttps://string-db.org/network/9606.ENSP00000422834Fraser extracellular matrix complex subunit 1.
USP17L30 protein networkhttps://string-db.org/network/9606.ENSP00000422887Ubiquitin specific peptidase 17 like family member 30.
SEPTIN11 protein networkhttps://string-db.org/network/9606.ENSP00000422896Septin-11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spi [...]
GTF2H2C protein networkhttps://string-db.org/network/9606.ENSP00000422907General transcription factor IIH subunit 2-like protein; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in [...]
STIMATE-MUSTN1 protein networkhttps://string-db.org/network/9606.ENSP00000422941STIMATE-MUSTN1 readthrough.
TRIM34 protein networkhttps://string-db.org/network/9606.ENSP00000422947Tripartite motif containing 34.
USP17L29 protein networkhttps://string-db.org/network/9606.ENSP00000422969Ubiquitin specific peptidase 17 like family member 29.
OCIAD2 protein networkhttps://string-db.org/network/9606.ENSP00000423014OCIA domain containing 2.
WDR36 protein networkhttps://string-db.org/network/9606.ENSP00000423067WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
CXorf40A protein networkhttps://string-db.org/network/9606.ENSP00000423099Protein CXorf40A; May have an important role of cell protection in inflammation reaction.
USP17L22 protein networkhttps://string-db.org/network/9606.ENSP00000423115Ubiquitin carboxyl-terminal hydrolase 17-like protein 22; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
GOLGA8O protein networkhttps://string-db.org/network/9606.ENSP00000423159Golgin A8 family member O; Belongs to the GOLGA6 family.
AADAT protein networkhttps://string-db.org/network/9606.ENSP00000423190Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. [...]
USP17L27 protein networkhttps://string-db.org/network/9606.ENSP00000423211Ubiquitin specific peptidase 17 like family member 27.
ZCCHC10 protein networkhttps://string-db.org/network/9606.ENSP00000423276Zinc finger CCHC-type containing 10.
H0Y980_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000423309Uncharacterized protein.
GALNTL6 protein networkhttps://string-db.org/network/9606.ENSP00000423313Polypeptide N-acetylgalactosaminyltransferase-like 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or t [...]
ENSP00000423325 protein networkhttps://string-db.org/network/9606.ENSP00000423325Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.
USP51 protein networkhttps://string-db.org/network/9606.ENSP00000423333Ubiquitin carboxyl-terminal hydrolase 51; Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys- 16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) [...]
MEGF10 protein networkhttps://string-db.org/network/9606.ENSP00000423354Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that bin [...]
USP26 protein networkhttps://string-db.org/network/9606.ENSP00000423390Ubiquitin carboxyl-terminal hydrolase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and [...]
RFPL4B protein networkhttps://string-db.org/network/9606.ENSP00000423391Ret finger protein like 4B.
MRPL36 protein networkhttps://string-db.org/network/9606.ENSP00000423399Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family.
LY75-CD302 protein networkhttps://string-db.org/network/9606.ENSP00000423463LY75-CD302 readthrough.
USP17L18 protein networkhttps://string-db.org/network/9606.ENSP00000423503Ubiquitin carboxyl-terminal hydrolase 17-like protein 18; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
TTC29 protein networkhttps://string-db.org/network/9606.ENSP00000423505Tetratricopeptide repeat domain 29.
SV2C protein networkhttps://string-db.org/network/9606.ENSP00000423541Synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates ves [...]
MACROH2A1 protein networkhttps://string-db.org/network/9606.ENSP00000423563Core histone macro-H2A.1; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limitin [...]
CCDC153 protein networkhttps://string-db.org/network/9606.ENSP00000423567Coiled-coil domain containing 153; Belongs to the UPF0610 family.
DAPP1 protein networkhttps://string-db.org/network/9606.ENSP00000423602Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
FBXL7 protein networkhttps://string-db.org/network/9606.ENSP00000423630F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent p [...]
SH3TC2 protein networkhttps://string-db.org/network/9606.ENSP00000423660SH3 domain and tetratricopeptide repeats 2.
CDK18 protein networkhttps://string-db.org/network/9606.ENSP00000423665Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2 [...]
NDUFA13 protein networkhttps://string-db.org/network/9606.ENSP00000423673NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...]
GNPDA1 protein networkhttps://string-db.org/network/9606.ENSP00000423674Glucosamine-6-phosphate isomerase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the emb [...]
USP17L28 protein networkhttps://string-db.org/network/9606.ENSP00000423777Ubiquitin specific peptidase 17 like family member 28.
ZFP62 protein networkhttps://string-db.org/network/9606.ENSP00000423820Zinc finger protein 62 homolog; May play a role in differentiating skeletal muscle.
GPX8 protein networkhttps://string-db.org/network/9606.ENSP00000423822Glutathione peroxidase 8; Belongs to the glutathione peroxidase family.
HOXC9 protein networkhttps://string-db.org/network/9606.ENSP00000423861Homeobox protein Hox-C9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PACRGL protein networkhttps://string-db.org/network/9606.ENSP00000423881PACRG-like protein; Parkin coregulated like.
KLHL5 protein networkhttps://string-db.org/network/9606.ENSP00000423897Kelch-like protein 5; Kelch like family member 5.
NPY5R protein networkhttps://string-db.org/network/9606.ENSP00000423917Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated [...]
THUMPD2 protein networkhttps://string-db.org/network/9606.ENSP00000423933THUMP domain containing 2; Belongs to the methyltransferase superfamily.
SHLD3 protein networkhttps://string-db.org/network/9606.ENSP00000424007Shieldin complex subunit 3; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex f [...]
FRG2 protein networkhttps://string-db.org/network/9606.ENSP00000424015Protein FRG2; FSHD region gene 2.
TAS2R50 protein networkhttps://string-db.org/network/9606.ENSP00000424040Taste receptor type 2 member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
SPDYE2B protein networkhttps://string-db.org/network/9606.ENSP00000424058Speedy protein E2B; speedy/RINGO cell cycle regulator family member E2B.
USP17L23 protein networkhttps://string-db.org/network/9606.ENSP00000424077Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23; Ubiquitin specific peptidase 17 like family member 23.
ELOVL7 protein networkhttps://string-db.org/network/9606.ENSP00000424123Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
MCTP1 protein networkhttps://string-db.org/network/9606.ENSP00000424126Multiple C2 and transmembrane domain-containing protein 1; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term [...]
EPPIN-WFDC6 protein networkhttps://string-db.org/network/9606.ENSP00000424176EPPIN-WFDC6 readthrough.
LAMTOR3 protein networkhttps://string-db.org/network/9606.ENSP00000424183Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...]
SMUG1 protein networkhttps://string-db.org/network/9606.ENSP00000424191Single-strand selective monofunctional uracil DNA glycosylase; Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for [...]
KLHL2 protein networkhttps://string-db.org/network/9606.ENSP00000424198Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most oft [...]
TENM3 protein networkhttps://string-db.org/network/9606.ENSP00000424226Teneurin-3; Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to contr [...]
PTTG2 protein networkhttps://string-db.org/network/9606.ENSP00000424261Securin-2; Pituitary tumor-transforming 2; Belongs to the securin family.
MRPS30 protein networkhttps://string-db.org/network/9606.ENSP00000424328Mitochondrial ribosomal protein S30.
E9PBE3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000424363Uncharacterized protein.
LMF2 protein networkhttps://string-db.org/network/9606.ENSP00000424381Lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through t [...]
PLRG1 protein networkhttps://string-db.org/network/9606.ENSP00000424417Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for act [...]
SAMD14 protein networkhttps://string-db.org/network/9606.ENSP00000424474Sterile alpha motif domain containing 14.
ZNF346 protein networkhttps://string-db.org/network/9606.ENSP00000424495Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins.
SH3RF2 protein networkhttps://string-db.org/network/9606.ENSP00000424497E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity. Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a s [...]
HTN1 protein networkhttps://string-db.org/network/9606.ENSP00000424501His1-(31-57)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histat [...]
TUSC3 protein networkhttps://string-db.org/network/9606.ENSP00000424544Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked olig [...]
CDHR2 protein networkhttps://string-db.org/network/9606.ENSP00000424565Cadherin-related family member 2; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, [...]
SLC35A4 protein networkhttps://string-db.org/network/9606.ENSP00000424566Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
FBN2 protein networkhttps://string-db.org/network/9606.ENSP00000424571Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in el [...]
PRPS1L1 protein networkhttps://string-db.org/network/9606.ENSP00000424595Ribose-phosphate pyrophosphokinase 3; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
DEFB4B protein networkhttps://string-db.org/network/9606.ENSP00000424598Defensin beta 4B.
TAAR9 protein networkhttps://string-db.org/network/9606.ENSP00000424607Trace amine-associated receptor 9; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...]
ADH4 protein networkhttps://string-db.org/network/9606.ENSP00000424630All-trans-retinol dehydrogenase [NAD(+)] ADH4; Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20- [...]
COPS4 protein networkhttps://string-db.org/network/9606.ENSP00000424655COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
TMEM167A protein networkhttps://string-db.org/network/9606.ENSP00000424707Protein kish-A; Involved in the early part of the secretory pathway. Belongs to the KISH family.
CLRN2 protein networkhttps://string-db.org/network/9606.ENSP00000424711Clarin-2; Clarin 2.
PKD2L2 protein networkhttps://string-db.org/network/9606.ENSP00000424725Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization; Belongs to the polycystin family.
ZGRF1 protein networkhttps://string-db.org/network/9606.ENSP00000424737Protein ZGRF1; Zinc finger GRF-type containing 1.
NEK1 protein networkhttps://string-db.org/network/9606.ENSP00000424757Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA dam [...]
AMOTL2 protein networkhttps://string-db.org/network/9606.ENSP00000424765Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-c [...]
MSANTD3-TMEFF1 protein networkhttps://string-db.org/network/9606.ENSP00000424768MSANTD3-TMEFF1 readthrough.
MTX3 protein networkhttps://string-db.org/network/9606.ENSP00000424798Metaxin-3; Could function in transport of proteins into the mitochondrion; Belongs to the metaxin family.
NEDD4 protein networkhttps://string-db.org/network/9606.ENSP00000424827E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin [...]
DDX4 protein networkhttps://string-db.org/network/9606.ENSP00000424838Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essenti [...]
SH3BP2 protein networkhttps://string-db.org/network/9606.ENSP00000424846SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase [...]
SRP19 protein networkhttps://string-db.org/network/9606.ENSP00000424870Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
CNOT6L protein networkhttps://string-db.org/network/9606.ENSP00000424896CCR4-NOT transcription complex subunit 6-like; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the majo [...]
HNRNPAB protein networkhttps://string-db.org/network/9606.ENSP00000425031Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site [...]
CCSER1 protein networkhttps://string-db.org/network/9606.ENSP00000425040Coiled-coil serine rich protein 1.
DTWD2 protein networkhttps://string-db.org/network/9606.ENSP00000425048DTW domain containing 2.
ATG12 protein networkhttps://string-db.org/network/9606.ENSP00000425107Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like [...]
UVSSA protein networkhttps://string-db.org/network/9606.ENSP00000425130UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rap [...]
SMG7 protein networkhttps://string-db.org/network/9606.ENSP00000425133Protein SMG7; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery invol [...]
C1orf216 protein networkhttps://string-db.org/network/9606.ENSP00000425166UPF0500 protein C1orf216; Chromosome 1 open reading frame 216.
COX18 protein networkhttps://string-db.org/network/9606.ENSP00000425261Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) acr [...]
USP17L24 protein networkhttps://string-db.org/network/9606.ENSP00000425375Ubiquitin specific peptidase 17 like family member 24.
ABLIM3 protein networkhttps://string-db.org/network/9606.ENSP00000425394Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
SATL1 protein networkhttps://string-db.org/network/9606.ENSP00000425421Spermidine/spermine N1-acetyl transferase like 1.
CAGE1 protein networkhttps://string-db.org/network/9606.ENSP00000425493Cancer-associated gene 1 protein; Cancer antigen 1.
UGT2A1 protein networkhttps://string-db.org/network/9606.ENSP00000425497UDP-glucuronosyltransferase 2A1; UDP glucuronosyltransferase family 2 member A1 complex locus; Belongs to the UDP-glycosyltransferase family.
PALLD protein networkhttps://string-db.org/network/9606.ENSP00000425556Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in [...]
EIF4E protein networkhttps://string-db.org/network/9606.ENSP00000425561Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome bi [...]
USP17L19 protein networkhttps://string-db.org/network/9606.ENSP00000425582Ubiquitin carboxyl-terminal hydrolase 17-like protein 19; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
EXOC3 protein networkhttps://string-db.org/network/9606.ENSP00000425587Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC6 family.
LIMCH1 protein networkhttps://string-db.org/network/9606.ENSP00000425631LIM and calponin homology domains 1.
HARS1 protein networkhttps://string-db.org/network/9606.ENSP00000425634Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Play [...]
ANKRD50 protein networkhttps://string-db.org/network/9606.ENSP00000425658Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1.
COX7C protein networkhttps://string-db.org/network/9606.ENSP00000425759Cytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
CFAP299 protein networkhttps://string-db.org/network/9606.ENSP00000425786Cilia- and flagella-associated protein 299; May be involved in spermatogenesis.
PGM3 protein networkhttps://string-db.org/network/9606.ENSP00000425809Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylati [...]
CAMK2D protein networkhttps://string-db.org/network/9606.ENSP00000425824Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling [...]
RNF150 protein networkhttps://string-db.org/network/9606.ENSP00000425840Ring finger protein 150.
BORCS8 protein networkhttps://string-db.org/network/9606.ENSP00000425864BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...]
SELENOP protein networkhttps://string-db.org/network/9606.ENSP00000425915Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues su [...]
USP17L5 protein networkhttps://string-db.org/network/9606.ENSP00000425955Ubiquitin carboxyl-terminal hydrolase 17-like protein 5; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...]
SPINK2 protein networkhttps://string-db.org/network/9606.ENSP00000425961Serine peptidase inhibitor Kazal type 2.
DROSHA protein networkhttps://string-db.org/network/9606.ENSP00000425979Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex th [...]
STMP1 protein networkhttps://string-db.org/network/9606.ENSP00000425996Short transmembrane mitochondrial protein 1.
HELT protein networkhttps://string-db.org/network/9606.ENSP00000426033Hairy and enhancer of split-related protein HELT; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'; Belongs to the HEY family.
TMEM267 protein networkhttps://string-db.org/network/9606.ENSP00000426067Transmembrane protein 267.
TRPC7 protein networkhttps://string-db.org/network/9606.ENSP00000426070Short transient receptor potential channel 7; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...]
ADH1C protein networkhttps://string-db.org/network/9606.ENSP00000426083Alcohol dehydrogenase 1C, gamma polypeptide.
MIB2 protein networkhttps://string-db.org/network/9606.ENSP00000426103E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notc [...]
CRIP2 protein networkhttps://string-db.org/network/9606.ENSP00000426119Cysteine rich protein 2.
GRAMD2B protein networkhttps://string-db.org/network/9606.ENSP00000426120GRAM domain containing 2B.
C6orf223 protein networkhttps://string-db.org/network/9606.ENSP00000426159Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223.
OSTC protein networkhttps://string-db.org/network/9606.ENSP00000426167Oligosaccharyltransferase complex subunit OSTC; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryote [...]
CCDC169 protein networkhttps://string-db.org/network/9606.ENSP00000426174Coiled-coil domain containing 169.
RAD17 protein networkhttps://string-db.org/network/9606.ENSP00000426191Cell cycle checkpoint protein RAD17; Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity [...]
SERINC5 protein networkhttps://string-db.org/network/9606.ENSP00000426237Serine incorporator 5; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the vira [...]
SNX25 protein networkhttps://string-db.org/network/9606.ENSP00000426255Sorting nexin-25; May be involved in several stages of intracellular trafficking.
ROPN1B protein networkhttps://string-db.org/network/9606.ENSP00000426271Ropporin-1B; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capaci [...]
MLIP protein networkhttps://string-db.org/network/9606.ENSP00000426290Muscular LMNA interacting protein.
PCP4L1 protein networkhttps://string-db.org/network/9606.ENSP00000426296Purkinje cell protein 4 like 1; Belongs to the PCP4 family.
TMEM161B protein networkhttps://string-db.org/network/9606.ENSP00000426354Transmembrane protein 161B; Belongs to the TMEM161 family.
MCIDAS protein networkhttps://string-db.org/network/9606.ENSP00000426359Multicilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required fo [...]
ZBTB38 protein networkhttps://string-db.org/network/9606.ENSP00000426387Zinc finger and BTB domain-containing protein 38; Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus seq [...]
ASTE1 protein networkhttps://string-db.org/network/9606.ENSP00000426421Protein asteroid homolog 1; Possible role in EGF receptor signaling.
RNASET2 protein networkhttps://string-db.org/network/9606.ENSP00000426455Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RN [...]
RNF4 protein networkhttps://string-db.org/network/9606.ENSP00000426503E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked po [...]
ZNF131 protein networkhttps://string-db.org/network/9606.ENSP00000426504Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regul [...]
AMER2 protein networkhttps://string-db.org/network/9606.ENSP00000426528APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphos [...]
KCTD16 protein networkhttps://string-db.org/network/9606.ENSP00000426548BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...]
TNIP3 protein networkhttps://string-db.org/network/9606.ENSP00000426613TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetrad [...]
ERBIN protein networkhttps://string-db.org/network/9606.ENSP00000426632Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits [...]
ETFDH protein networkhttps://string-db.org/network/9606.ENSP00000426638Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone; Belongs to the ETF-QO/FixC family.
WNT8A protein networkhttps://string-db.org/network/9606.ENSP00000426653Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.
ANAPC4 protein networkhttps://string-db.org/network/9606.ENSP00000426654Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...]
GOLGA8K protein networkhttps://string-db.org/network/9606.ENSP00000426691Golgin A8 family member K; Belongs to the GOLGA8 family.
GUCY1B1 protein networkhttps://string-db.org/network/9606.ENSP00000426786Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP. Belongs to the adenylyl cyclase class-4/guanylyl c [...]
PROM1 protein networkhttps://string-db.org/network/9606.ENSP00000426809Prominin-1; May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization [...]
ZFYVE16 protein networkhttps://string-db.org/network/9606.ENSP00000426848Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to [...]
RACK1 protein networkhttps://string-db.org/network/9606.ENSP00000426909Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a [...]
AHRR-2 protein networkhttps://string-db.org/network/9606.ENSP00000426932Aryl-hydrocarbon receptor repressor.
MRPS27 protein networkhttps://string-db.org/network/9606.ENSP0000042694128S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondria [...]
E9PCH4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000426948Uncharacterized protein.
YJEFN3 protein networkhttps://string-db.org/network/9606.ENSP00000426964YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis.
NXF5 protein networkhttps://string-db.org/network/9606.ENSP00000426978Nuclear RNA export factor 5; Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neuro [...]
CLOCK protein networkhttps://string-db.org/network/9606.ENSP00000426983Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates var [...]
GFM2 protein networkhttps://string-db.org/network/9606.ENSP00000427004Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in co [...]
RIMS2 protein networkhttps://string-db.org/network/9606.ENSP00000427018Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes.
CDKN2AIP protein networkhttps://string-db.org/network/9606.ENSP00000427108CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to th [...]
RAI14 protein networkhttps://string-db.org/network/9606.ENSP00000427123Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhe [...]
ANKRD13D protein networkhttps://string-db.org/network/9606.ENSP00000427130Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...]
DLEU7 protein networkhttps://string-db.org/network/9606.ENSP00000427177Leukemia-associated protein 7; Deleted in lymphocytic leukemia 7.
APBB2 protein networkhttps://string-db.org/network/9606.ENSP00000427211Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein.
MARCHF1 protein networkhttps://string-db.org/network/9606.ENSP00000427223E3 ubiquitin-protein ligase MARCHF1; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subse [...]
USP17L20 protein networkhttps://string-db.org/network/9606.ENSP00000427264Ubiquitin carboxyl-terminal hydrolase 17-like protein 20; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
CXCL2 protein networkhttps://string-db.org/network/9606.ENSP00000427279C-X-C motif chemokine 2; Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor c [...]
FOXR2 protein networkhttps://string-db.org/network/9606.ENSP00000427329Forkhead box R2.
DIO3 protein networkhttps://string-db.org/network/9606.ENSP00000427336Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronin [...]
CT45A5 protein networkhttps://string-db.org/network/9606.ENSP00000427342Cancer/testis antigen family 45 member A5.
USP17L26 protein networkhttps://string-db.org/network/9606.ENSP00000427366Ubiquitin specific peptidase 17 like family member 26.
SREK1IP1 protein networkhttps://string-db.org/network/9606.ENSP00000427401Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival.
SMIM20 protein networkhttps://string-db.org/network/9606.ENSP00000427407Small integral membrane protein 20; [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) comp [...]
CDC42SE2 protein networkhttps://string-db.org/network/9606.ENSP00000427421CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape ch [...]
TNFAIP8 protein networkhttps://string-db.org/network/9606.ENSP00000427424Tumor necrosis factor alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 act [...]
FAM218A protein networkhttps://string-db.org/network/9606.ENSP00000427428Protein FAM218A; Family with sequence similarity 218 member A.
SPCS3 protein networkhttps://string-db.org/network/9606.ENSP00000427463Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated [...]
CEBPA protein networkhttps://string-db.org/network/9606.ENSP00000427514CCAAT/enhancer-binding protein alpha; Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and [...]
CEP192 protein networkhttps://string-db.org/network/9606.ENSP00000427550Centrosomal protein of 192 kDa; Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome m [...]
DDR1 protein networkhttps://string-db.org/network/9606.ENSP00000427552Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remode [...]
ABL2 protein networkhttps://string-db.org/network/9606.ENSP00000427562Tyrosine-protein kinase ABL2; Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in resp [...]
FHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000427567FH2 domain-containing protein 1; Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber format [...]
GABRA2 protein networkhttps://string-db.org/network/9606.ENSP00000427603Gamma-aminobutyric acid receptor subunit alpha-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain [...]
SLC4A9 protein networkhttps://string-db.org/network/9606.ENSP00000427661Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex. Belongs to the anion exchanger (TC 2.A.31) family.
MTTP protein networkhttps://string-db.org/network/9606.ENSP00000427679Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of p [...]
FAM153B protein networkhttps://string-db.org/network/9606.ENSP00000427684Protein FAM153B; Family with sequence similarity 153 member B.
WDR1 protein networkhttps://string-db.org/network/9606.ENSP00000427687WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin- mediated actin severing (By similarity). Involved in cyto [...]
GYPB protein networkhttps://string-db.org/network/9606.ENSP00000427690Glycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes; Belongs to the glycophorin-A family.
TOB1 protein networkhttps://string-db.org/network/9606.ENSP00000427695Protein Tob1; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CP [...]
WWC1 protein networkhttps://string-db.org/network/9606.ENSP00000427772Protein KIBRA; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting a [...]
WWP1 protein networkhttps://string-db.org/network/9606.ENSP00000427793NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...]
NACA2 protein networkhttps://string-db.org/network/9606.ENSP00000427802Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as th [...]
C8orf34 protein networkhttps://string-db.org/network/9606.ENSP00000427820Uncharacterized protein C8orf34; Chromosome 8 open reading frame 34.
DMTN protein networkhttps://string-db.org/network/9606.ENSP00000427866Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upo [...]
TENM2 protein networkhttps://string-db.org/network/9606.ENSP00000427874Ten-2 intracellular domain; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth [...]
ANKAR protein networkhttps://string-db.org/network/9606.ENSP00000427882Ankyrin and armadillo repeat containing.
HS3ST5 protein networkhttps://string-db.org/network/9606.ENSP00000427888Heparan sulfate glucosamine 3-O-sulfotransferase 5; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine res [...]
KIF13B protein networkhttps://string-db.org/network/9606.ENSP00000427900Kinesin-like protein KIF13B; Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the int [...]
RHOBTB2 protein networkhttps://string-db.org/network/9606.ENSP00000427926Rho-related BTB domain-containing protein 2; Rho related BTB domain containing 2; Belongs to the small GTPase superfamily. Rho family.
CCDC160 protein networkhttps://string-db.org/network/9606.ENSP00000427951Coiled-coil domain containing 160; Belongs to the CCDC160 family.
RANBP17 protein networkhttps://string-db.org/network/9606.ENSP00000427975Ran-binding protein 17; May function as a nuclear transport receptor.
DPYSL2 protein networkhttps://string-db.org/network/9606.ENSP00000427985Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for s [...]
ENSP00000428055 protein networkhttps://string-db.org/network/9606.ENSP00000428055Novel protein.
PIK3R1 protein networkhttps://string-db.org/network/9606.ENSP00000428056Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p [...]
RPL30 protein networkhttps://string-db.org/network/9606.ENSP00000428085Ribosomal protein L30.
ERLIN2 protein networkhttps://string-db.org/network/9606.ENSP00000428112Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes s [...]
SLC45A4 protein networkhttps://string-db.org/network/9606.ENSP00000428137Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
MPP2 protein networkhttps://string-db.org/network/9606.ENSP00000428182MAGUK p55 subfamily member 2; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons [...]
SDCBP protein networkhttps://string-db.org/network/9606.ENSP00000428184Syntenin-1; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenes [...]
FBXO32 protein networkhttps://string-db.org/network/9606.ENSP00000428205F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...]
UBE2V2 protein networkhttps://string-db.org/network/9606.ENSP00000428209Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked [...]
IRGM protein networkhttps://string-db.org/network/9606.ENSP00000428220Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulat [...]
RPL26L1 protein networkhttps://string-db.org/network/9606.ENSP00000428223Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family.
CETN3 protein networkhttps://string-db.org/network/9606.ENSP00000428259Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function.
DGLUCY protein networkhttps://string-db.org/network/9606.ENSP00000428263D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline.
FER1L6 protein networkhttps://string-db.org/network/9606.ENSP00000428280Fer-1-like protein 6; Fer-1 like family member 6.
LEPROTL1 protein networkhttps://string-db.org/network/9606.ENSP00000428281Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of redu [...]
PCDHGB4 protein networkhttps://string-db.org/network/9606.ENSP00000428288Protocadherin gamma-B4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
SERPINE3 protein networkhttps://string-db.org/network/9606.ENSP00000428316Serpin E3; Probable serine protease inhibitor.
VASH2 protein networkhttps://string-db.org/network/9606.ENSP00000428324Tubulinyl-Tyr carboxypeptidase 2; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spind [...]
SFTA3 protein networkhttps://string-db.org/network/9606.ENSP00000428331Surfactant-associated protein 3; Putative surfactant protein. May be involved in wound healing and in the reduction of the surface tension at the ocular surface.
SPSB2 protein networkhttps://string-db.org/network/9606.ENSP00000428338SPRY domain-containing SOCS box protein 2; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitina [...]
ANGPT1 protein networkhttps://string-db.org/network/9606.ENSP00000428340Angiopoietin-1; Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell surviv [...]
RGS21 protein networkhttps://string-db.org/network/9606.ENSP00000428343Regulator of G-protein signaling 21; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
CLVS1 protein networkhttps://string-db.org/network/9606.ENSP00000428402Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2).
RIMS1 protein networkhttps://string-db.org/network/9606.ENSP00000428417Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Ess [...]
TCEA1 protein networkhttps://string-db.org/network/9606.ENSP00000428426Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...]
DLX6 protein networkhttps://string-db.org/network/9606.ENSP00000428480Homeobox protein DLX-6; Distal-less homeobox 6.
PBK protein networkhttps://string-db.org/network/9606.ENSP00000428489Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When pho [...]
GFRA2 protein networkhttps://string-db.org/network/9606.ENSP00000428518GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosin [...]
ST3GAL1 protein networkhttps://string-db.org/network/9606.ENSP00000428540CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr [...]
TMEM200B protein networkhttps://string-db.org/network/9606.ENSP00000428544Transmembrane protein 200B.
SEC24B protein networkhttps://string-db.org/network/9606.ENSP00000428564Protein transport protein Sec24B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...]
LY6E protein networkhttps://string-db.org/network/9606.ENSP00000428572Lymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs ma [...]
SMIM12 protein networkhttps://string-db.org/network/9606.ENSP00000428585Small integral membrane protein 12.
PCDHGB6 protein networkhttps://string-db.org/network/9606.ENSP00000428603Protocadherin gamma-B6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
SLC10A5 protein networkhttps://string-db.org/network/9606.ENSP00000428612Sodium/bile acid cotransporter 5; Solute carrier family 10 member 5.
UTP14C protein networkhttps://string-db.org/network/9606.ENSP00000428619U3 small nucleolar RNA-associated protein 14 homolog C; Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By sim [...]
FBXO41 protein networkhttps://string-db.org/network/9606.ENSP00000428646F-box only protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
NAIP protein networkhttps://string-db.org/network/9606.ENSP00000428657Baculoviral IAP repeat-containing protein 1; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pr [...]
ZNF829 protein networkhttps://string-db.org/network/9606.ENSP00000428679Zinc finger protein 829; May be involved in transcriptional regulation.
RNF217 protein networkhttps://string-db.org/network/9606.ENSP00000428698Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the u [...]
DENND3 protein networkhttps://string-db.org/network/9606.ENSP00000428714DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound for [...]
CRYBG2 protein networkhttps://string-db.org/network/9606.ENSP00000428746Beta/gamma crystallin domain-containing protein 2; Crystallin beta-gamma domain containing 2; Belongs to the beta/gamma-crystallin family.
STAU2 protein networkhttps://string-db.org/network/9606.ENSP00000428756Double-stranded RNA-binding protein Staufen homolog 2; RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesi [...]
CLDN23 protein networkhttps://string-db.org/network/9606.ENSP00000428780Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
AP3M2 protein networkhttps://string-db.org/network/9606.ENSP00000428787AP-3 complex subunit mu-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral struct [...]
VDAC3 protein networkhttps://string-db.org/network/9606.ENSP00000428845Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
SMIM18 protein networkhttps://string-db.org/network/9606.ENSP00000428858Small integral membrane protein 18.
CES5A protein networkhttps://string-db.org/network/9606.ENSP00000428864Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
FAM83A protein networkhttps://string-db.org/network/9606.ENSP00000428876Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EG [...]
ZNF721 protein networkhttps://string-db.org/network/9606.ENSP00000428878Zinc finger protein 721; May be involved in transcriptional regulation.
LYN protein networkhttps://string-db.org/network/9606.ENSP00000428924Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune re [...]
ZFP41-2 protein networkhttps://string-db.org/network/9606.ENSP00000428966Zinc finger protein 41 homolog; A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis; Belongs to the krueppel C2H2-type zinc-finger protein family.
RNF19A protein networkhttps://string-db.org/network/9606.ENSP00000428968E3 ubiquitin-protein ligase RNF19A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transf [...]
PTP4A3 protein networkhttps://string-db.org/network/9606.ENSP00000428976Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive act [...]
CCNC protein networkhttps://string-db.org/network/9606.ENSP00000428982Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey infor [...]
GRIA1 protein networkhttps://string-db.org/network/9606.ENSP00000428994Glutamate receptor 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter [...]
ANKRD46 protein networkhttps://string-db.org/network/9606.ENSP00000429015Ankyrin repeat domain 46.
PCDHGB2 protein networkhttps://string-db.org/network/9606.ENSP00000429018Protocadherin gamma-B2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
INTS9 protein networkhttps://string-db.org/network/9606.ENSP00000429065Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
NKAIN3 protein networkhttps://string-db.org/network/9606.ENSP00000429073Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Sodium/potassium transporting ATPase interacting 3; Belongs to the NKAIN family.
UBR5 protein networkhttps://string-db.org/network/9606.ENSP00000429084E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are desta [...]
CCNE2 protein networkhttps://string-db.org/network/9606.ENSP00000429089G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily.
ZNF674 protein networkhttps://string-db.org/network/9606.ENSP00000429148Zinc finger protein 674; May be involved in transcriptional regulation.
FAM49B protein networkhttps://string-db.org/network/9606.ENSP00000429150Protein FAM49B.
SLC25A30 protein networkhttps://string-db.org/network/9606.ENSP00000429168Kidney mitochondrial carrier protein 1; Probable transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family.
ENDOV protein networkhttps://string-db.org/network/9606.ENSP00000429190Endonuclease V; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ss [...]
SLC25A37 protein networkhttps://string-db.org/network/9606.ENSP00000429200Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into [...]
TRNP1 protein networkhttps://string-db.org/network/9606.ENSP00000429216TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Re [...]
STMN2 protein networkhttps://string-db.org/network/9606.ENSP00000429243Stathmin-2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negati [...]
PCDHGB1 protein networkhttps://string-db.org/network/9606.ENSP00000429273Protocadherin gamma-B1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
TMEM125 protein networkhttps://string-db.org/network/9606.ENSP00000429275Transmembrane protein 125.
DOCK2 protein networkhttps://string-db.org/network/9606.ENSP00000429283Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as [...]
TPD52 protein networkhttps://string-db.org/network/9606.ENSP00000429309Tumor protein D52; Belongs to the TPD52 family.
EIF2B4 protein networkhttps://string-db.org/network/9606.ENSP00000429323Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP.
PNMA2 protein networkhttps://string-db.org/network/9606.ENSP00000429344Paraneoplastic antigen Ma2; PNMA family member 2; Belongs to the PNMA family.
FAM92A protein networkhttps://string-db.org/network/9606.ENSP00000429367Protein FAM92A; Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis. In cooperation with CBY1 it is invol [...]
RPS20 protein networkhttps://string-db.org/network/9606.ENSP00000429374Ribosomal protein S20.
HS6ST2 protein networkhttps://string-db.org/network/9606.ENSP00000429473Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...]
TRIQK protein networkhttps://string-db.org/network/9606.ENSP00000429517Triple QxxK/R motif-containing protein; May play a role in cell growth and maintenance of cell morphology; Belongs to the TRIQK family.
NKX6-3 protein networkhttps://string-db.org/network/9606.ENSP00000429553Homeobox protein Nkx-6.3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas.
UNC13A protein networkhttps://string-db.org/network/9606.ENSP00000429562Protein unc-13 homolog A; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synapt [...]
PCDHGA6 protein networkhttps://string-db.org/network/9606.ENSP00000429601Protocadherin gamma-A6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
FANCD2OS protein networkhttps://string-db.org/network/9606.ENSP00000429608FANCD2 opposite strand.
MYBL1 protein networkhttps://string-db.org/network/9606.ENSP00000429633Myb-related protein A; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expr [...]
ATP6V0E1 protein networkhttps://string-db.org/network/9606.ENSP00000429690V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the V-ATPase e1/e2 subunit family.
COX6C protein networkhttps://string-db.org/network/9606.ENSP00000429707Cytochrome c oxidase subunit 6C; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain [...]
SHISAL2A protein networkhttps://string-db.org/network/9606.ENSP00000429726Protein shisa-like-2A; Shisa like 2A.
NPIPB13 protein networkhttps://string-db.org/network/9606.ENSP00000429734Nuclear pore complex interacting protein family, member B13.
STK3 protein networkhttps://string-db.org/network/9606.ENSP00000429744Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by intern [...]
SLC20A2 protein networkhttps://string-db.org/network/9606.ENSP00000429754Sodium-dependent phosphate transporter 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for [...]
INSYN2A protein networkhttps://string-db.org/network/9606.ENSP00000429763Inhibitory synaptic factor 2A; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hype [...]
ZNF260 protein networkhttps://string-db.org/network/9606.ENSP00000429803Zinc finger protein 260; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of gene [...]
PCDHA3 protein networkhttps://string-db.org/network/9606.ENSP00000429808Protocadherin alpha-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
CLINT1 protein networkhttps://string-db.org/network/9606.ENSP00000429824Clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi networ [...]
PCDHGA5 protein networkhttps://string-db.org/network/9606.ENSP00000429834Protocadherin gamma-A5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
TVP23C-CDRT4 protein networkhttps://string-db.org/network/9606.ENSP00000429865Golgi apparatus membrane protein TVP23 homolog; TVP23C-CDRT4 readthrough.
FAM178B protein networkhttps://string-db.org/network/9606.ENSP00000429896Protein FAM178B; Family with sequence similarity 178 member B.
ASAP1 protein networkhttps://string-db.org/network/9606.ENSP00000429900Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation fac [...]
EIF3H protein networkhttps://string-db.org/network/9606.ENSP00000429931Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
ENY2 protein networkhttps://string-db.org/network/9606.ENSP00000429986Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histon [...]
TSPAN18 protein networkhttps://string-db.org/network/9606.ENSP00000429993Tetraspanin-18; Tetraspanin 18.
ATXN7L3B protein networkhttps://string-db.org/network/9606.ENSP00000430000Ataxin-7-like protein 3B; By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone d [...]
PCDHGA7 protein networkhttps://string-db.org/network/9606.ENSP00000430024Protocadherin gamma-A7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
LYRM2 protein networkhttps://string-db.org/network/9606.ENSP00000430025LYR motif containing 2.
TXNRD3 protein networkhttps://string-db.org/network/9606.ENSP00000430031Thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 [...]
CNBD1 protein networkhttps://string-db.org/network/9606.ENSP00000430073Cyclic nucleotide-binding domain-containing protein 1; Cyclic nucleotide binding domain containing 1.
AMPD1 protein networkhttps://string-db.org/network/9606.ENSP00000430075AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
GABRP protein networkhttps://string-db.org/network/9606.ENSP00000430100Gamma-aminobutyric acid receptor subunit pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and o [...]
HMBOX1 protein networkhttps://string-db.org/network/9606.ENSP00000430110Homeobox-containing protein 1; Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telo [...]
RALYL protein networkhttps://string-db.org/network/9606.ENSP00000430128RNA-binding Raly-like protein; RALY RNA binding protein like.
ALG11 protein networkhttps://string-db.org/network/9606.ENSP00000430236GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic [...]
RNF130 protein networkhttps://string-db.org/network/9606.ENSP00000430237E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin-protein ligase.
EBF2 protein networkhttps://string-db.org/network/9606.ENSP00000430241Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with t [...]
SBSN protein networkhttps://string-db.org/network/9606.ENSP00000430242Suprabasin.
EPHX2 protein networkhttps://string-db.org/network/9606.ENSP00000430269Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobi [...]
ETV3L protein networkhttps://string-db.org/network/9606.ENSP00000430271ETS translocation variant 3-like protein; Transcriptional regulator; Belongs to the ETS family.
MCF2 protein networkhttps://string-db.org/network/9606.ENSP00000430276MCF2-transforming protein; Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to [...]
ATP6V1C1 protein networkhttps://string-db.org/network/9606.ENSP00000430282V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a sp [...]
TDRP protein networkhttps://string-db.org/network/9606.ENSP00000430325Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family.
INTS8 protein networkhttps://string-db.org/network/9606.ENSP00000430338Integrator complex subunit 8; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Inte [...]
PLCD1 protein networkhttps://string-db.org/network/9606.ENSP000004303441-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by acti [...]
HDAC2 protein networkhttps://string-db.org/network/9606.ENSP00000430432Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...]
CNOT8 protein networkhttps://string-db.org/network/9606.ENSP00000430493CCR4-NOT transcription complex subunit 8; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalyti [...]
UQCRB protein networkhttps://string-db.org/network/9606.ENSP00000430494Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which dr [...]
PTDSS1 protein networkhttps://string-db.org/network/9606.ENSP00000430548Phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, [...]
ATOX1 protein networkhttps://string-db.org/network/9606.ENSP00000430598Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family.
HEPH protein networkhttps://string-db.org/network/9606.ENSP00000430620Hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate i [...]
CA1 protein networkhttps://string-db.org/network/9606.ENSP00000430656Carbonic anhydrase 1; Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.
IKBKB protein networkhttps://string-db.org/network/9606.ENSP00000430684Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory [...]
TFF3 protein networkhttps://string-db.org/network/9606.ENSP00000430690Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen).
EIF5AL1 protein networkhttps://string-db.org/network/9606.ENSP00000430706Eukaryotic translation initiation factor 5A-1-like; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of [...]
TRHR protein networkhttps://string-db.org/network/9606.ENSP00000430711Thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; [...]
E5RI56_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000430774Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
SMIM23 protein networkhttps://string-db.org/network/9606.ENSP00000430818Small integral membrane protein 23.
ZNF706 protein networkhttps://string-db.org/network/9606.ENSP00000430823Zinc finger protein 706; Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.
KCNB2 protein networkhttps://string-db.org/network/9606.ENSP00000430846Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth mus [...]
NPIPB11 protein networkhttps://string-db.org/network/9606.ENSP00000430853Nuclear pore complex interacting protein family member B11.
GPBAR1 protein networkhttps://string-db.org/network/9606.ENSP00000430886G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP productio [...]
CCDC71L protein networkhttps://string-db.org/network/9606.ENSP00000430897Coiled-coil domain-containing protein 71L; Coiled-coil domain containing 71 like.
C1orf210 protein networkhttps://string-db.org/network/9606.ENSP00000430918Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane.
HMGB4 protein networkhttps://string-db.org/network/9606.ENSP00000430919High mobility group box 4; Belongs to the HMGB family.
ADGRB1 protein networkhttps://string-db.org/network/9606.ENSP00000430945Adhesion G protein-coupled receptor B1; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulate [...]
HSF4 protein networkhttps://string-db.org/network/9606.ENSP00000430947Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. [...]
IDO1 protein networkhttps://string-db.org/network/9606.ENSP00000430950Indoleamine 2,3-dioxygenase 1; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune [...]
RNF145 protein networkhttps://string-db.org/network/9606.ENSP00000430955RING finger protein 145; E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, nega [...]
SDR16C5 protein networkhttps://string-db.org/network/9606.ENSP00000431010Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans-retinol in all-trans-retinaldehyde. No [...]
ARHGEF10 protein networkhttps://string-db.org/network/9606.ENSP00000431012Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves.
MRPL22 protein networkhttps://string-db.org/network/9606.ENSP00000431040Mitochondrial ribosomal protein L22.
GSTK1 protein networkhttps://string-db.org/network/9606.ENSP00000431049Glutathione S-transferase kappa 1; Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).
DNPEP protein networkhttps://string-db.org/network/9606.ENSP00000431076Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.
PCDHGA1 protein networkhttps://string-db.org/network/9606.ENSP00000431083Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
C1QTNF5 protein networkhttps://string-db.org/network/9606.ENSP00000431140Complement C1q tumor necrosis factor-related protein 5; C1q and TNF related 5.
EID1 protein networkhttps://string-db.org/network/9606.ENSP00000431162EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be [...]
BTBD10 protein networkhttps://string-db.org/network/9606.ENSP00000431186BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in pre [...]
ZNF345 protein networkhttps://string-db.org/network/9606.ENSP00000431202Zinc finger protein 345; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RPLP2 protein networkhttps://string-db.org/network/9606.ENSP0000043124060S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis.
IGLL5 protein networkhttps://string-db.org/network/9606.ENSP00000431254Immunoglobulin lambda like polypeptide 5.
ZFP82 protein networkhttps://string-db.org/network/9606.ENSP00000431265Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
LPXN protein networkhttps://string-db.org/network/9606.ENSP00000431284Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negati [...]
CSKMT protein networkhttps://string-db.org/network/9606.ENSP00000431287Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial; Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethyl [...]
TATDN3 protein networkhttps://string-db.org/network/9606.ENSP00000431376Putative deoxyribonuclease TATDN3; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
API5 protein networkhttps://string-db.org/network/9606.ENSP00000431391Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated D [...]
NTRK1 protein networkhttps://string-db.org/network/9606.ENSP00000431418High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferati [...]
KRTAP5-9 protein networkhttps://string-db.org/network/9606.ENSP00000431443Keratin associated protein 5-9.
CD3G protein networkhttps://string-db.org/network/9606.ENSP00000431445T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cel [...]
FAM89B protein networkhttps://string-db.org/network/9606.ENSP00000431459Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TG [...]
NEDD8-MDP1 protein networkhttps://string-db.org/network/9606.ENSP00000431482NEDD8-MDP1 readthrough.
HSF1 protein networkhttps://string-db.org/network/9606.ENSP00000431512Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), lea [...]
TMEM25 protein networkhttps://string-db.org/network/9606.ENSP00000431548Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.
POU2F2 protein networkhttps://string-db.org/network/9606.ENSP00000431603POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to acti [...]
MS4A18 protein networkhttps://string-db.org/network/9606.ENSP00000431607Membrane spanning 4-domains A18.
TAS2R43 protein networkhttps://string-db.org/network/9606.ENSP00000431719Taste receptor type 2 member 43; Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calc [...]
PCDHA2 protein networkhttps://string-db.org/network/9606.ENSP00000431748Protocadherin alpha-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
CFAP54 protein networkhttps://string-db.org/network/9606.ENSP00000431759Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella.
IL32 protein networkhttps://string-db.org/network/9606.ENSP00000431775Interleukin-32; Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways o [...]
EIF3F protein networkhttps://string-db.org/network/9606.ENSP00000431800Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
CSRP3 protein networkhttps://string-db.org/network/9606.ENSP00000431813Cysteine and glycine-rich protein 3; Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding [...]
NPIPA7 protein networkhttps://string-db.org/network/9606.ENSP00000431814Nuclear pore complex interacting protein family member A7.
FAU protein networkhttps://string-db.org/network/9606.ENSP00000431822Ubiquitin-like protein FUBI; FAU ubiquitin like and ribosomal protein S30 fusion.
SLC24A4 protein networkhttps://string-db.org/network/9606.ENSP00000431840Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neur [...]
NPIPB6 protein networkhttps://string-db.org/network/9606.ENSP00000431871Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family.
USP35 protein networkhttps://string-db.org/network/9606.ENSP00000431876Ubiquitin specific peptidase 35.
TYK2 protein networkhttps://string-db.org/network/9606.ENSP00000431885Non-receptor tyrosine-protein kinase TYK2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/ [...]
OR10S1 protein networkhttps://string-db.org/network/9606.ENSP00000431914Olfactory receptor 10S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
AMBRA1 protein networkhttps://string-db.org/network/9606.ENSP00000431926Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal develo [...]
SAMD1 protein networkhttps://string-db.org/network/9606.ENSP00000431971Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall.
MUC15 protein networkhttps://string-db.org/network/9606.ENSP00000431983Mucin-15; May play a role in the cell adhesion to the extracellular matrix.
CAPN1 protein networkhttps://string-db.org/network/9606.ENSP00000431984Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs [...]
OR52B2 protein networkhttps://string-db.org/network/9606.ENSP00000432011Olfactory receptor 52B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
H7C0V5_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000432016ANKHD1-EIF4EBP3 readthrough.
EBLN2 protein networkhttps://string-db.org/network/9606.ENSP00000432104Endogenous Bornavirus-like nucleoprotein 2; May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligome [...]
WDR74 protein networkhttps://string-db.org/network/9606.ENSP00000432119WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processi [...]
KBTBD3 protein networkhttps://string-db.org/network/9606.ENSP00000432163Kelch repeat and BTB domain containing 3.
CCDC17 protein networkhttps://string-db.org/network/9606.ENSP00000432172Coiled-coil domain containing 17.
CHMP1B protein networkhttps://string-db.org/network/9606.ENSP00000432279Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodi [...]
SPA17 protein networkhttps://string-db.org/network/9606.ENSP00000432305Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohyd [...]
ATG13 protein networkhttps://string-db.org/network/9606.ENSP00000432412Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the p [...]
OR5M11 protein networkhttps://string-db.org/network/9606.ENSP00000432417Olfactory receptor 5M11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GPR61 protein networkhttps://string-db.org/network/9606.ENSP00000432456G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway. Shows a reciprocal regulatory interaction with the melatonin rece [...]
TMEM262 protein networkhttps://string-db.org/network/9606.ENSP00000432459Transmembrane protein 262.
BRK1 protein networkhttps://string-db.org/network/9606.ENSP00000432472Protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 [...]
NAALAD2 protein networkhttps://string-db.org/network/9606.ENSP00000432481N-acetylated-alpha-linked acidic dipeptidase 2; Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the pepti [...]
SAAL1 protein networkhttps://string-db.org/network/9606.ENSP00000432487Protein SAAL1; Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
ZNF202 protein networkhttps://string-db.org/network/9606.ENSP00000432504Zinc finger protein 202; Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipopro [...]
JAK3 protein networkhttps://string-db.org/network/9606.ENSP00000432511Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate a [...]
C11orf98 protein networkhttps://string-db.org/network/9606.ENSP00000432523Uncharacterized protein C11orf98; Chromosome 11 open reading frame 98.
HTN3 protein networkhttps://string-db.org/network/9606.ENSP00000432561His3-(20-30)-peptide; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histat [...]
SPTBN2 protein networkhttps://string-db.org/network/9606.ENSP00000432568Spectrin beta chain, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton; Belongs to the spectrin family.
FAT3 protein networkhttps://string-db.org/network/9606.ENSP00000432586Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development.
YPEL4 protein networkhttps://string-db.org/network/9606.ENSP00000432648Protein yippee-like 4; Yippee like 4; Belongs to the yippee family.
SMTNL1 protein networkhttps://string-db.org/network/9606.ENSP00000432651Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylati [...]
CFL1 protein networkhttps://string-db.org/network/9606.ENSP00000432660Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. [...]
PIGY protein networkhttps://string-db.org/network/9606.ENSP00000432688Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc [...]
UQCC3 protein networkhttps://string-db.org/network/9606.ENSP00000432692Ubiquinol-cytochrome-c reductase complex assembly factor 3; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...]
TRMT9B protein networkhttps://string-db.org/network/9606.ENSP00000432695Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9.
TP53AIP1 protein networkhttps://string-db.org/network/9606.ENSP00000432743P53-regulated apoptosis-inducing protein 1; May play an important role in mediating p53/TP53-dependent apoptosis.
CKAP5 protein networkhttps://string-db.org/network/9606.ENSP00000432768Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytop [...]
EYA4 protein networkhttps://string-db.org/network/9606.ENSP00000432770Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repai [...]
KDM2A protein networkhttps://string-db.org/network/9606.ENSP00000432786Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated [...]
ACRV1 protein networkhttps://string-db.org/network/9606.ENSP00000432816Acrosomal vesicle protein 1.
MEX3A protein networkhttps://string-db.org/network/9606.ENSP00000432845RNA-binding protein MEX3A; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.
RNPC3 protein networkhttps://string-db.org/network/9606.ENSP00000432886RNA-binding region-containing protein 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1 [...]
PTPRK protein networkhttps://string-db.org/network/9606.ENSP00000432973Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR si [...]
RGS5 protein networkhttps://string-db.org/network/9606.ENSP00000433001Regulator of G-protein signaling 5; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G( [...]
RBM4B protein networkhttps://string-db.org/network/9606.ENSP00000433071RNA-binding protein 4B; Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity).
TRIM3 protein networkhttps://string-db.org/network/9606.ENSP00000433102Tripartite motif-containing protein 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recyc [...]
DKK3 protein networkhttps://string-db.org/network/9606.ENSP00000433112Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...]
TMEM41B protein networkhttps://string-db.org/network/9606.ENSP00000433126Transmembrane protein 41B; Required for normal motor neuron development (By similarity). Required for autophagosome formation. Belongs to the TMEM41 family.
CASP1 protein networkhttps://string-db.org/network/9606.ENSP00000433138Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defen [...]
BBIP1 protein networkhttps://string-db.org/network/9606.ENSP00000433157BBSome interacting protein 1.
EMSY protein networkhttps://string-db.org/network/9606.ENSP00000433205BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the [...]
PTH protein networkhttps://string-db.org/network/9606.ENSP00000433208Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis [...]
GSDMD protein networkhttps://string-db.org/network/9606.ENSP00000433209Gasdermin-D, C-terminal; [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CAS [...]
MS4A1 protein networkhttps://string-db.org/network/9606.ENSP00000433277B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of [...]
KCNJ5 protein networkhttps://string-db.org/network/9606.ENSP00000433295G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow [...]
FAM118B protein networkhttps://string-db.org/network/9606.ENSP00000433343Protein FAM118B; May play a role in Cajal bodies formation. Belongs to the FAM118 family.
TMEM9B protein networkhttps://string-db.org/network/9606.ENSP00000433361Transmembrane protein 9B; Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways; Belongs to [...]
PCDHA6 protein networkhttps://string-db.org/network/9606.ENSP00000433378Protocadherin alpha-6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
NT5C1B-RDH14 protein networkhttps://string-db.org/network/9606.ENSP00000433415NT5C1B-RDH14 readthrough.
ARL15 protein networkhttps://string-db.org/network/9606.ENSP00000433427ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; Belongs to the small GTPase superfamily. Arf family.
CREBZF protein networkhttps://string-db.org/network/9606.ENSP00000433459CREB/ATF bZIP transcription factor; Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. A [...]
FLI1 protein networkhttps://string-db.org/network/9606.ENSP00000433488Friend leukemia integration 1 transcription factor; Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'- C[CA]GGAAGT-3'; Belongs to the ETS family.
CALCB protein networkhttps://string-db.org/network/9606.ENSP00000433490Calcitonin gene-related peptide 2; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points towar [...]
DENND2B protein networkhttps://string-db.org/network/9606.ENSP00000433528DENN domain-containing protein 2B; [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of [...]
CRYAB protein networkhttps://string-db.org/network/9606.ENSP00000433560Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress [...]
NPIPA5 protein networkhttps://string-db.org/network/9606.ENSP00000433597Nuclear pore complex interacting protein family member A5.
TRAF6 protein networkhttps://string-db.org/network/9606.ENSP00000433623TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, I [...]
FCGR3B protein networkhttps://string-db.org/network/9606.ENSP00000433642Low affinity immunoglobulin gamma Fc region receptor III-B; Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. C [...]
EIF4G2 protein networkhttps://string-db.org/network/9606.ENSP00000433664Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by [...]
FGD4 protein networkhttps://string-db.org/network/9606.ENSP00000433666FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the ac [...]
NCAPD3 protein networkhttps://string-db.org/network/9606.ENSP00000433681Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid ax [...]
SPRN protein networkhttps://string-db.org/network/9606.ENSP00000433712Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
BANF1 protein networkhttps://string-db.org/network/9606.ENSP00000433760Barrier-to-autointegration factor, N-terminally processed; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chroma [...]
MS4A14 protein networkhttps://string-db.org/network/9606.ENSP00000433761Membrane-spanning 4-domains subfamily A member 14; May be involved in signal transduction as a component of a multimeric receptor complex.
CYHR1 protein networkhttps://string-db.org/network/9606.ENSP00000433769Cysteine and histidine rich 1; Belongs to the CYHR1 family.
ZNF585B protein networkhttps://string-db.org/network/9606.ENSP00000433773Zinc finger protein 585B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TSPAN19 protein networkhttps://string-db.org/network/9606.ENSP00000433816Putative tetraspanin-19; Tetraspanin 19.
B3GAT1 protein networkhttps://string-db.org/network/9606.ENSP00000433847Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan bios [...]
CLNS1A protein networkhttps://string-db.org/network/9606.ENSP00000433919Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small n [...]
PNLIPRP1 protein networkhttps://string-db.org/network/9606.ENSP00000433933Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholin [...]
E9PSI1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000433967Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
RNH1 protein networkhttps://string-db.org/network/9606.ENSP00000433999Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
H2AX protein networkhttps://string-db.org/network/9606.ENSP00000434024Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineri [...]
FZD4 protein networkhttps://string-db.org/network/9606.ENSP00000434034Frizzled-4; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibiti [...]
EIF1AD protein networkhttps://string-db.org/network/9606.ENSP00000434056Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation.
RAB15 protein networkhttps://string-db.org/network/9606.ENSP00000434103Ras-related protein Rab-15; May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. Belongs to the small GTPase superfamily. Rab family.
KCNC3 protein networkhttps://string-db.org/network/9606.ENSP00000434241Potassium voltage-gated channel subfamily C member 3; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in r [...]
TMPRSS13 protein networkhttps://string-db.org/network/9606.ENSP00000434279Transmembrane serine protease 13; Belongs to the peptidase S1 family.
CYB5RL protein networkhttps://string-db.org/network/9606.ENSP00000434343NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methem [...]
PUF60 protein networkhttps://string-db.org/network/9606.ENSP00000434359Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with F [...]
SLC6A5 protein networkhttps://string-db.org/network/9606.ENSP00000434364Sodium- and chloride-dependent glycine transporter 2; Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into pres [...]
NPIPB8 protein networkhttps://string-db.org/network/9606.ENSP00000434399Nuclear pore complex interacting protein family member B8; Belongs to the NPIP family.
SERPINH1 protein networkhttps://string-db.org/network/9606.ENSP00000434412Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
FAM111A protein networkhttps://string-db.org/network/9606.ENSP00000434435Protein FAM111A; Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. May directly function at replication forks, explaining why [...]
ARFGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000434442ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi comp [...]
INTS4 protein networkhttps://string-db.org/network/9606.ENSP00000434466Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...]
ACER3 protein networkhttps://string-db.org/network/9606.ENSP00000434480Alkaline ceramidase 3; Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4- ceramides, dihydroceramides and phytoceramides [...]
SELENOH protein networkhttps://string-db.org/network/9606.ENSP00000434511Selenoprotein H; May be involved in a redox-related process.
EML3 protein networkhttps://string-db.org/network/9606.ENSP00000434513Echinoderm microtubule-associated protein-like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP fam [...]
SLC43A3 protein networkhttps://string-db.org/network/9606.ENSP00000434515Solute carrier family 43 member 3; Putative transporter; Belongs to the SLC43A transporter (TC 2.A.1.44) family.
TXNRD1 protein networkhttps://string-db.org/network/9606.ENSP00000434516Thioredoxin reductase 1, cytoplasmic; Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of c [...]
MAML2 protein networkhttps://string-db.org/network/9606.ENSP00000434552Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 mor [...]
SOGA3 protein networkhttps://string-db.org/network/9606.ENSP00000434570Protein SOGA3; SOGA family member 3.
C6orf141 protein networkhttps://string-db.org/network/9606.ENSP00000434602Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141.
CDC27 protein networkhttps://string-db.org/network/9606.ENSP00000434614Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
PCDHA8 protein networkhttps://string-db.org/network/9606.ENSP00000434655Protocadherin alpha-8; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
USP50 protein networkhttps://string-db.org/network/9606.ENSP00000434676Inactive ubiquitin carboxyl-terminal hydrolase 50; Has no peptidase activity; Belongs to the peptidase C19 family.
IL18BP protein networkhttps://string-db.org/network/9606.ENSP00000434717Interleukin-18-binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.
CCDC90B protein networkhttps://string-db.org/network/9606.ENSP00000434724Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B.
ATP6V0B protein networkhttps://string-db.org/network/9606.ENSP00000434729V-type proton ATPase 21 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of [...]
PARP10 protein networkhttps://string-db.org/network/9606.ENSP00000434776Protein mono-ADP-ribosyltransferase PARP10; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it i [...]
NRK protein networkhttps://string-db.org/network/9606.ENSP00000434830Nik-related protein kinase; May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling [...]
TSKU protein networkhttps://string-db.org/network/9606.ENSP00000434847Tsukushin; Tsukushi, small leucine rich proteoglycan.
LRRC24 protein networkhttps://string-db.org/network/9606.ENSP00000434849Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24.
THNSL1 protein networkhttps://string-db.org/network/9606.ENSP00000434887Threonine synthase like 1.
CLP1 protein networkhttps://string-db.org/network/9606.ENSP00000434995Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (d [...]
DEFB134 protein networkhttps://string-db.org/network/9606.ENSP00000435010Beta-defensin 134; Has antibacterial activity; Belongs to the beta-defensin family.
RPS25 protein networkhttps://string-db.org/network/9606.ENSP00000435096Ribosomal protein S25.
KIAA0408 protein networkhttps://string-db.org/network/9606.ENSP00000435150Uncharacterized protein KIAA0408; KIAA0408.
RAB30 protein networkhttps://string-db.org/network/9606.ENSP00000435189Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
BCLAF1 protein networkhttps://string-db.org/network/9606.ENSP00000435210Bcl-2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'en [...]
TEAD1 protein networkhttps://string-db.org/network/9606.ENSP00000435233Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...]
ZSCAN5C protein networkhttps://string-db.org/network/9606.ENSP00000435234Zinc finger and SCAN domain-containing protein 5C; May be involved in transcriptional regulation.
PAFAH1B2 protein networkhttps://string-db.org/network/9606.ENSP00000435289Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit.
CRACR2B protein networkhttps://string-db.org/network/9606.ENSP00000435299EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE).
PCDHA4 protein networkhttps://string-db.org/network/9606.ENSP00000435300Protocadherin alpha-4; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of spec [...]
NPIPA8 protein networkhttps://string-db.org/network/9606.ENSP00000435325Nuclear pore complex interacting protein family member A8.
GJB7 protein networkhttps://string-db.org/network/9606.ENSP00000435355Gap junction beta-7 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
TOR1AIP1 protein networkhttps://string-db.org/network/9606.ENSP00000435365Torsin-1A-interacting protein 1; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-typ [...]
CCNJ protein networkhttps://string-db.org/network/9606.ENSP00000435373Cyclin-J; Cyclin J.
SLN protein networkhttps://string-db.org/network/9606.ENSP00000435380Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation [...]
PLEKHA7 protein networkhttps://string-db.org/network/9606.ENSP00000435389Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus- [...]
RPS6KA1 protein networkhttps://string-db.org/network/9606.ENSP00000435412Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the [...]
DDIAS protein networkhttps://string-db.org/network/9606.ENSP00000435421DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival.
LGALS8 protein networkhttps://string-db.org/network/9606.ENSP00000435460Galectin-8; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. De [...]
KIRREL3 protein networkhttps://string-db.org/network/9606.ENSP00000435466Processed kin of IRRE-like protein 3; Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fi [...]
POLN protein networkhttps://string-db.org/network/9606.ENSP00000435506DNA polymerase nu; DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurat [...]
ZIC4 protein networkhttps://string-db.org/network/9606.ENSP00000435509Zinc finger protein ZIC 4; Binds to DNA; Belongs to the GLI C2H2-type zinc-finger protein family.
CCKBR protein networkhttps://string-db.org/network/9606.ENSP00000435534Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, [...]
ZC2HC1C protein networkhttps://string-db.org/network/9606.ENSP00000435550Zinc finger C2HC-type containing 1C; Belongs to the ZC2HC1 family.
MROH1 protein networkhttps://string-db.org/network/9606.ENSP00000435565Maestro heat like repeat family member 1.
AGBL2 protein networkhttps://string-db.org/network/9606.ENSP00000435582Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...]
EPS8L2 protein networkhttps://string-db.org/network/9606.ENSP00000435585Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In [...]
EID3 protein networkhttps://string-db.org/network/9606.ENSP00000435619EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The com [...]
C1orf94 protein networkhttps://string-db.org/network/9606.ENSP00000435634Uncharacterized protein C1orf94; Chromosome 1 open reading frame 94.
CNTN5 protein networkhttps://string-db.org/network/9606.ENSP00000435637Contactin-5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal [...]
GRIK4 protein networkhttps://string-db.org/network/9606.ENSP00000435648Glutamate receptor ionotropic, kainate 4; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Gl [...]
GATA4 protein networkhttps://string-db.org/network/9606.ENSP00000435712Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it bin [...]
ASCL3 protein networkhttps://string-db.org/network/9606.ENSP00000435770Achaete-scute homolog 3; Transcriptional repressor. Inhibits myogenesis (By similarity).
RPS13 protein networkhttps://string-db.org/network/9606.ENSP00000435777Ribosomal protein S13.
ANKRD42 protein networkhttps://string-db.org/network/9606.ENSP00000435790Ankyrin repeat domain 42.
EHF protein networkhttps://string-db.org/network/9606.ENSP00000435835ETS homologous factor; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-res [...]
MS4A6A protein networkhttps://string-db.org/network/9606.ENSP00000435844Membrane-spanning 4-domains subfamily A member 6A; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family.
KCNV1 protein networkhttps://string-db.org/network/9606.ENSP00000435954Potassium voltage-gated channel subfamily V member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the thresh [...]
OR5M10 protein networkhttps://string-db.org/network/9606.ENSP00000436004Olfactory receptor 5M10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TRAPPC4 protein networkhttps://string-db.org/network/9606.ENSP00000436005Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
PCDHA9 protein networkhttps://string-db.org/network/9606.ENSP00000436042Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
ST3GAL4 protein networkhttps://string-db.org/network/9606.ENSP00000436047CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences [...]
EIF3M protein networkhttps://string-db.org/network/9606.ENSP00000436049Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
SAA2 protein networkhttps://string-db.org/network/9606.ENSP00000436126Serum amyloid A-2 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family.
TP53I11 protein networkhttps://string-db.org/network/9606.ENSP00000436152Tumor protein p53 inducible protein 11.
ZNF707 protein networkhttps://string-db.org/network/9606.ENSP00000436212Zinc finger protein 707; May be involved in transcriptional regulation.
CCS protein networkhttps://string-db.org/network/9606.ENSP00000436318Copper chaperone for superoxide dismutase; Delivers copper to copper zinc superoxide dismutase (SOD1); In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
OMP protein networkhttps://string-db.org/network/9606.ENSP00000436376Olfactory marker protein; May act as a modulator of the olfactory signal-transduction cascade; Belongs to the olfactory marker protein family.
GNLY protein networkhttps://string-db.org/network/9606.ENSP00000436423Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Myc [...]
OR4D10 protein networkhttps://string-db.org/network/9606.ENSP00000436424Olfactory receptor 4D10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PCDHA7 protein networkhttps://string-db.org/network/9606.ENSP00000436426Protocadherin alpha-7; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of spec [...]
TAS2R46 protein networkhttps://string-db.org/network/9606.ENSP00000436450Taste receptor type 2 member 46; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
OR52I1 protein networkhttps://string-db.org/network/9606.ENSP00000436453Olfactory receptor 52I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
NUCB2 protein networkhttps://string-db.org/network/9606.ENSP00000436455Nucleobindin-2; Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanin [...]
IGSF9B protein networkhttps://string-db.org/network/9606.ENSP00000436552Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion.
PCDHA5 protein networkhttps://string-db.org/network/9606.ENSP00000436557Protocadherin alpha-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PRR23D2 protein networkhttps://string-db.org/network/9606.ENSP00000436580Proline-rich protein 23D1; Proline rich 23 domain containing 2; Belongs to the PRR23 family.
ECHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000436585Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylma [...]
TMEM218 protein networkhttps://string-db.org/network/9606.ENSP00000436596Transmembrane protein 218; May be involved in ciliary biogenesis or function.
GALNT4 protein networkhttps://string-db.org/network/9606.ENSP00000436604Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threon [...]
ADM protein networkhttps://string-db.org/network/9606.ENSP00000436607Proadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and elec [...]
C8orf82 protein networkhttps://string-db.org/network/9606.ENSP00000436621UPF0598 protein C8orf82; Chromosome 8 open reading frame 82.
SAC3D1 protein networkhttps://string-db.org/network/9606.ENSP00000436649SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression.
NXF1 protein networkhttps://string-db.org/network/9606.ENSP00000436679Nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (T [...]
ARMS2 protein networkhttps://string-db.org/network/9606.ENSP00000436682Age-related maculopathy susceptibility 2.
CARD18 protein networkhttps://string-db.org/network/9606.ENSP00000436691Caspase recruitment domain-containing protein 18; Inhibits generation of IL-1-beta by interacting with caspase- 1 and preventing its association with RIP2. Down-regulates the release of IL1B.
KBTBD4 protein networkhttps://string-db.org/network/9606.ENSP00000436713Kelch repeat and BTB domain containing 4.
HCAR3 protein networkhttps://string-db.org/network/9606.ENSP00000436714Hydroxycarboxylic acid receptor 3; Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiol [...]
KIAA0100 protein networkhttps://string-db.org/network/9606.ENSP00000436773Protein KIAA0100; May be involved in membrane trafficking. Belongs to the SABRE family.
SLC35F2 protein networkhttps://string-db.org/network/9606.ENSP00000436785Solute carrier family 35 member F2; Putative solute transporter.
KMT2A protein networkhttps://string-db.org/network/9606.ENSP00000436786Histone-lysine N-methyltransferase 2A; Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein com [...]
MUC5B protein networkhttps://string-db.org/network/9606.ENSP00000436812Mucin-5B; Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
CACNG5 protein networkhttps://string-db.org/network/9606.ENSP00000436836Voltage-dependent calcium channel gamma-5 subunit; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of [...]
LBHD1 protein networkhttps://string-db.org/network/9606.ENSP00000436848LBH domain containing 1.
CELF1 protein networkhttps://string-db.org/network/9606.ENSP00000436864CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability [...]
DBX1 protein networkhttps://string-db.org/network/9606.ENSP00000436881Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major cl [...]
PRR23D1 protein networkhttps://string-db.org/network/9606.ENSP00000436891Proline rich 23 domain containing 1.
SMIM3 protein networkhttps://string-db.org/network/9606.ENSP00000436897Small integral membrane protein 3.
NFRKB protein networkhttps://string-db.org/network/9606.ENSP00000436926Nuclear factor related to kappa-B-binding protein; Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. Belongs to the NFRKB family.
DNAAF3 protein networkhttps://string-db.org/network/9606.ENSP00000436975Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
CYB5R2 protein networkhttps://string-db.org/network/9606.ENSP00000437041NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemogl [...]
MYO18A protein networkhttps://string-db.org/network/9606.ENSP00000437073Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi memb [...]
CHI3L2 protein networkhttps://string-db.org/network/9606.ENSP00000437082Chitinase-3-like protein 2; Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family.
C4orf50 protein networkhttps://string-db.org/network/9606.ENSP00000437121Uncharacterized protein C4orf50; Chromosome 4 open reading frame 50.
HSPA8 protein networkhttps://string-db.org/network/9606.ENSP00000437125Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthes [...]
TIAM2 protein networkhttps://string-db.org/network/9606.ENSP00000437188T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimu [...]
DICER1 protein networkhttps://string-db.org/network/9606.ENSP00000437256Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs an [...]
TNKS1BP1 protein networkhttps://string-db.org/network/9606.ENSP00000437271182 kDa tankyrase-1-binding protein; Tankyrase 1 binding protein 1.
ZAR1L protein networkhttps://string-db.org/network/9606.ENSP00000437289ZAR1-like protein; Zygote arrest 1 like; Belongs to the ZAR1 family.
ANAPC15 protein networkhttps://string-db.org/network/9606.ENSP00000437360Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
ENO2 protein networkhttps://string-db.org/network/9606.ENSP00000437402Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons [...]
GRAPL protein networkhttps://string-db.org/network/9606.ENSP00000437409GRB2-related adapter protein-like; GRB2 related adaptor protein like.
FBXL17 protein networkhttps://string-db.org/network/9606.ENSP00000437464F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerizatio [...]
CCDC166 protein networkhttps://string-db.org/network/9606.ENSP00000437468Coiled-coil domain containing 166.
CCDC189 protein networkhttps://string-db.org/network/9606.ENSP00000437532Coiled-coil domain containing 189.
LATS1 protein networkhttps://string-db.org/network/9606.ENSP00000437550Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...]
IQSEC3 protein networkhttps://string-db.org/network/9606.ENSP00000437554IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1.
KLRC3-2 protein networkhttps://string-db.org/network/9606.ENSP00000437563NKG2-E type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
ZNF891 protein networkhttps://string-db.org/network/9606.ENSP00000437590Zinc finger protein 891; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF611 protein networkhttps://string-db.org/network/9606.ENSP00000437616Zinc finger protein 611; May be involved in transcriptional regulation.
HMGA2 protein networkhttps://string-db.org/network/9606.ENSP00000437621High mobility group AT-hook 2.
OR6J1 protein networkhttps://string-db.org/network/9606.ENSP00000437629Olfactory receptor 6J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PHC1 protein networkhttps://string-db.org/network/9606.ENSP00000437659Polyhomeotic-like protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includi [...]
HTR2A protein networkhttps://string-db.org/network/9606.ENSP000004377375-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, p [...]
SFSWAP protein networkhttps://string-db.org/network/9606.ENSP00000437738Splicing factor, suppressor of white-apricot homolog; Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of [...]
BCORL1 protein networkhttps://string-db.org/network/9606.ENSP00000437775BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6. [...]
LDHC protein networkhttps://string-db.org/network/9606.ENSP00000437783L-lactate dehydrogenase C chain; Possible role in sperm motility.
CDH22 protein networkhttps://string-db.org/network/9606.ENSP00000437790Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...]
ZNF641 protein networkhttps://string-db.org/network/9606.ENSP00000437832Zinc finger protein 641; Transcriptional activator. Activates transcriptional activities of SRE and AP-1; Belongs to the krueppel C2H2-type zinc-finger protein family.
TRPM1 protein networkhttps://string-db.org/network/9606.ENSP00000437849Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade [...]
GPRASP2 protein networkhttps://string-db.org/network/9606.ENSP00000437872G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors.
MTRNR2L5 protein networkhttps://string-db.org/network/9606.ENSP00000437910Humanin-like 5; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
HIF1A protein networkhttps://string-db.org/network/9606.ENSP00000437955Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, incl [...]
HEATR5A protein networkhttps://string-db.org/network/9606.ENSP00000437968HEAT repeat containing 5A.
VNN3 protein networkhttps://string-db.org/network/9606.ENSP00000438024Vascular non-inflammatory molecule 3; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cystea [...]
KLRC1 protein networkhttps://string-db.org/network/9606.ENSP00000438038NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
CCDC91 protein networkhttps://string-db.org/network/9606.ENSP00000438040Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydr [...]
PAAF1 protein networkhttps://string-db.org/network/9606.ENSP00000438071Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 in [...]
GGA3 protein networkhttps://string-db.org/network/9606.ENSP00000438085ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathr [...]
TOMM5 protein networkhttps://string-db.org/network/9606.ENSP00000438204Mitochondrial import receptor subunit TOM5 homolog; Translocase of outer mitochondrial membrane 5.
MANSC1 protein networkhttps://string-db.org/network/9606.ENSP00000438205MANSC domain containing 1.
SP6 protein networkhttps://string-db.org/network/9606.ENSP00000438209Transcription factor Sp6; Promotes cell proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family.
KLRF2 protein networkhttps://string-db.org/network/9606.ENSP00000438244Killer cell lectin-like receptor subfamily F member 2; C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interactio [...]
CALU protein networkhttps://string-db.org/network/9606.ENSP00000438248Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinit [...]
TJP2 protein networkhttps://string-db.org/network/9606.ENSP00000438262Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions.
LRIT2 protein networkhttps://string-db.org/network/9606.ENSP00000438264Leucine rich repeat, Ig-like and transmembrane domains 2.
BBS12 protein networkhttps://string-db.org/network/9606.ENSP00000438273Bardet-Biedl syndrome 12 protein; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the T [...]
MAGEA8 protein networkhttps://string-db.org/network/9606.ENSP00000438293Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
TRMT112 protein networkhttps://string-db.org/network/9606.ENSP00000438349Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) po [...]
KIF1A protein networkhttps://string-db.org/network/9606.ENSP00000438388Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors. Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axon [...]
IST1 protein networkhttps://string-db.org/network/9606.ENSP00000438399IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in [...]
CLDN24 protein networkhttps://string-db.org/network/9606.ENSP00000438400Putative claudin-24; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
SLAMF1 protein networkhttps://string-db.org/network/9606.ENSP00000438406Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interact [...]
TIMM8B protein networkhttps://string-db.org/network/9606.ENSP00000438455Mitochondrial import inner membrane translocase subunit Tim8 B; Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane prote [...]
PGAM5 protein networkhttps://string-db.org/network/9606.ENSP00000438465Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosph [...]
HHAT protein networkhttps://string-db.org/network/9606.ENSP00000438468Protein-cysteine N-palmitoyltransferase HHAT; Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP; Belongs to the membrane-bound acyltransferase family. [...]
KPNA2 protein networkhttps://string-db.org/network/9606.ENSP00000438483Importin subunit alpha-1; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...]
F5H423_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000438507Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.
KLHL35 protein networkhttps://string-db.org/network/9606.ENSP00000438526Kelch-like protein 35; Kelch like family member 35.
H2AJ protein networkhttps://string-db.org/network/9606.ENSP00000438553Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...]
PIAS1 protein networkhttps://string-db.org/network/9606.ENSP00000438574E3 SUMO-protein ligase PIAS1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...]
PLD4 protein networkhttps://string-db.org/network/9606.ENSP000004386775'-3' exonuclease PLD4; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentra [...]
ACADVL protein networkhttps://string-db.org/network/9606.ENSP00000438689Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accom [...]
SMG8 protein networkhttps://string-db.org/network/9606.ENSP00000438748Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SM [...]
PRR20C protein networkhttps://string-db.org/network/9606.ENSP00000438757Proline rich 20C.
CUL7 protein networkhttps://string-db.org/network/9606.ENSP00000438788Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubu [...]
HNF1A protein networkhttps://string-db.org/network/9606.ENSP00000438804Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver (By similarity). Bi [...]
OR13C2 protein networkhttps://string-db.org/network/9606.ENSP00000438815Olfactory receptor 13C2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PACC1 protein networkhttps://string-db.org/network/9606.ENSP00000438863Proton-activated chloride channel; Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediat [...]
NOVA1 protein networkhttps://string-db.org/network/9606.ENSP00000438875RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons.
CDK5RAP3 protein networkhttps://string-db.org/network/9606.ENSP00000438886CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene t [...]
CACNB4 protein networkhttps://string-db.org/network/9606.ENSP00000438949Voltage-dependent L-type calcium channel subunit beta-4; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...]
ZCCHC8 protein networkhttps://string-db.org/network/9606.ENSP00000438993Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non- [...]
TUBA1A protein networkhttps://string-db.org/network/9606.ENSP00000439020Detyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site [...]
HAUS5 protein networkhttps://string-db.org/network/9606.ENSP00000439056HAUS augmin-like complex subunit 5; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
COA8-2 protein networkhttps://string-db.org/network/9606.ENSP00000439065Uncharacterized protein.
CRADD protein networkhttps://string-db.org/network/9606.ENSP00000439068Death domain-containing protein CRADD; Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits [...]
NFE2 protein networkhttps://string-db.org/network/9606.ENSP00000439120Transcription factor NF-E2 45 kDa subunit; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 [...]
BANF2 protein networkhttps://string-db.org/network/9606.ENSP00000439128Barrier-to-autointegration factor-like protein; May play a role in BANF1 regulation and influence tissue- specific roles of BANF1; Belongs to the BAF family.
TBCE protein networkhttps://string-db.org/network/9606.ENSP00000439170Tubulin-specific chaperone E; Tubulin folding cofactor E.
POTEE protein networkhttps://string-db.org/network/9606.ENSP00000439189POTE ankyrin domain family member E; In the C-terminal section; belongs to the actin family.
MTRNR2L1 protein networkhttps://string-db.org/network/9606.ENSP00000439228Humanin-like 1; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
CIZ1 protein networkhttps://string-db.org/network/9606.ENSP00000439244Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1.
FKBP9 protein networkhttps://string-db.org/network/9606.ENSP00000439250Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis.
RIMS4 protein networkhttps://string-db.org/network/9606.ENSP00000439287Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis.
SSUH2 protein networkhttps://string-db.org/network/9606.ENSP00000439378Protein SSUH2 homolog; Plays a role in odontogenesis.
ZNF667 protein networkhttps://string-db.org/network/9606.ENSP00000439402Zinc finger protein 667; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF133 protein networkhttps://string-db.org/network/9606.ENSP00000439427Zinc finger protein 133; May be involved in transcriptional regulation as a repressor.
ZNF415 protein networkhttps://string-db.org/network/9606.ENSP00000439435Zinc finger protein 415; Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional [...]
PPIAL4D protein networkhttps://string-db.org/network/9606.ENSP00000439444Peptidyl-prolyl cis-trans isomerase A-like 4D; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...]
PDCD2 protein networkhttps://string-db.org/network/9606.ENSP00000439467Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
DMXL1 protein networkhttps://string-db.org/network/9606.ENSP00000439479DmX-like protein 1; Dmx like 1.
ATXN7-2 protein networkhttps://string-db.org/network/9606.ENSP00000439585Ataxin 7.
ARHGAP45 protein networkhttps://string-db.org/network/9606.ENSP00000439601Minor histocompatibility antigen HA-1; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spread [...]
PLEKHG5 protein networkhttps://string-db.org/network/9606.ENSP00000439625Pleckstrin homology domain-containing family G member 5; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons ( [...]
MTRNR2L8 protein networkhttps://string-db.org/network/9606.ENSP00000439666Humanin-like 8; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
TRERF1 protein networkhttps://string-db.org/network/9606.ENSP00000439689Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1.
TMEM50B protein networkhttps://string-db.org/network/9606.ENSP00000439768Transmembrane protein 50B; Belongs to the UPF0220 family.
ZMYND8 protein networkhttps://string-db.org/network/9606.ENSP00000439800Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to i [...]
CHERP protein networkhttps://string-db.org/network/9606.ENSP00000439856Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation.
P3R3URF-PIK3R3 protein networkhttps://string-db.org/network/9606.ENSP00000439913Uncharacterized protein.
HOMER3 protein networkhttps://string-db.org/network/9606.ENSP00000439937Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...]
MTRNR2L7 protein networkhttps://string-db.org/network/9606.ENSP00000439985Humanin-like 7; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
ARF1 protein networkhttps://string-db.org/network/9606.ENSP00000440005ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces [...]
TCEANC protein networkhttps://string-db.org/network/9606.ENSP00000440038Transcription elongation factor A N-terminal and central domain containing.
ATP2A2 protein networkhttps://string-db.org/network/9606.ENSP00000440045Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic [...]
JCHAIN protein networkhttps://string-db.org/network/9606.ENSP00000440066Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it in [...]
CPNE6 protein networkhttps://string-db.org/network/9606.ENSP00000440077Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). [...]
MED24 protein networkhttps://string-db.org/network/9606.ENSP00000440100Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
FAM120B protein networkhttps://string-db.org/network/9606.ENSP00000440125Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); [...]
FAM9A protein networkhttps://string-db.org/network/9606.ENSP00000440163Protein FAM9A; Family with sequence similarity 9 member A.
RAB19 protein networkhttps://string-db.org/network/9606.ENSP00000440167Ras-related protein Rab-19; RAB19, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family.
PDYN protein networkhttps://string-db.org/network/9606.ENSP00000440185Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (B [...]
TDRD3 protein networkhttps://string-db.org/network/9606.ENSP00000440190Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmet [...]
TBC1D30 protein networkhttps://string-db.org/network/9606.ENSP00000440207TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.
FMC1-LUC7L2 protein networkhttps://string-db.org/network/9606.ENSP00000440222Putative RNA-binding protein Luc7-like 2; FMC1-LUC7L2 readthrough.
ME3 protein networkhttps://string-db.org/network/9606.ENSP00000440246NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family.
SH2B2 protein networkhttps://string-db.org/network/9606.ENSP00000440273SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras [...]
ABCB9 protein networkhttps://string-db.org/network/9606.ENSP00000440288ATP-binding cassette sub-family B member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broa [...]
SLC29A2 protein networkhttps://string-db.org/network/9606.ENSP00000440329Equilibrative nucleoside transporter 2; Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitr [...]
ADIG protein networkhttps://string-db.org/network/9606.ENSP00000440331Adipogenin; Plays a role in stimulating adipocyte differentiation and development; Belongs to the adipogenin family.
ZNF124 protein networkhttps://string-db.org/network/9606.ENSP00000440365Zinc finger protein 124; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MCF2L protein networkhttps://string-db.org/network/9606.ENSP00000440374Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC4 [...]
ANKRD49 protein networkhttps://string-db.org/network/9606.ENSP00000440396Ankyrin repeat domain-containing protein 49; Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF-kappaB pathway (By [...]
DDX11 protein networkhttps://string-db.org/network/9606.ENSP00000440402ATP-dependent DNA helicase DDX11; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and hetero [...]
CLEC4C protein networkhttps://string-db.org/network/9606.ENSP00000440428C-type lectin domain family 4 member C; Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose- terminat [...]
ATF7IP protein networkhttps://string-db.org/network/9606.ENSP00000440440Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chrom [...]
ZNF573 protein networkhttps://string-db.org/network/9606.ENSP00000440464Zinc finger protein 573; May be involved in transcriptional regulation.
PSMD9 protein networkhttps://string-db.org/network/9606.ENSP0000044048526S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During [...]
GDAP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000440498Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1.
DPP3 protein networkhttps://string-db.org/network/9606.ENSP00000440502Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).
KIAA1958 protein networkhttps://string-db.org/network/9606.ENSP00000440504Uncharacterized protein KIAA1958; KIAA1958.
TIFAB protein networkhttps://string-db.org/network/9606.ENSP00000440509TRAF-interacting protein with FHA domain-containing protein B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA.
CHD4 protein networkhttps://string-db.org/network/9606.ENSP00000440542Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Belongs to the SNF2/RAD [...]
GRM4 protein networkhttps://string-db.org/network/9606.ENSP00000440556Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
CYP2E1 protein networkhttps://string-db.org/network/9606.ENSP00000440689Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the [...]
NPIPB5 protein networkhttps://string-db.org/network/9606.ENSP00000440703Nuclear pore complex interacting protein family member B5.
SYTL1 protein networkhttps://string-db.org/network/9606.ENSP00000440704Synaptotagmin-like protein 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cyto [...]
METTL26 protein networkhttps://string-db.org/network/9606.ENSP00000440765Methyltransferase like 26.
EVI5 protein networkhttps://string-db.org/network/9606.ENSP00000440826Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May [...]
CACFD1 protein networkhttps://string-db.org/network/9606.ENSP00000440832Calcium channel flower domain containing 1.
ZNF185 protein networkhttps://string-db.org/network/9606.ENSP00000440847Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation.
PARPBP protein networkhttps://string-db.org/network/9606.ENSP00000440850PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologou [...]
NR4A1 protein networkhttps://string-db.org/network/9606.ENSP00000440864Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the N [...]
PLD5 protein networkhttps://string-db.org/network/9606.ENSP00000440896Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family.
LNPK protein networkhttps://string-db.org/network/9606.ENSP00000440905Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nas [...]
PRORP protein networkhttps://string-db.org/network/9606.ENSP00000440915Mitochondrial ribonuclease P catalytic subunit; Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleave [...]
PACSIN3 protein networkhttps://string-db.org/network/9606.ENSP00000440945Protein kinase C and casein kinase substrate in neurons protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of [...]
RASA4B protein networkhttps://string-db.org/network/9606.ENSP00000440982RAS p21 protein activator 4B.
AP3B2 protein networkhttps://string-db.org/network/9606.ENSP00000440984AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and [...]
VARS2 protein networkhttps://string-db.org/network/9606.ENSP00000441000Valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase 2, mitochondrial.
GRAMD1A protein networkhttps://string-db.org/network/9606.ENSP00000441032Protein Aster-A; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique doma [...]
GPR161 protein networkhttps://string-db.org/network/9606.ENSP00000441039G-protein coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex [...]
SLC16A1 protein networkhttps://string-db.org/network/9606.ENSP00000441065Monocarboxylate transporter 1; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-ch [...]
NDUFC1 protein networkhttps://string-db.org/network/9606.ENSP00000441126NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...]
NOL8 protein networkhttps://string-db.org/network/9606.ENSP00000441140Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expressio [...]
CLTCL1 protein networkhttps://string-db.org/network/9606.ENSP00000441158Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma me [...]
RHBG protein networkhttps://string-db.org/network/9606.ENSP00000441197Ammonium transporter Rh type B; Functions as a specific ammonium transporter.
USP36 protein networkhttps://string-db.org/network/9606.ENSP00000441214Ubiquitin carboxyl-terminal hydrolase 36; Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in rib [...]
TSHR protein networkhttps://string-db.org/network/9606.ENSP00000441235Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The act [...]
ENSP00000441269 protein networkhttps://string-db.org/network/9606.ENSP00000441269Solute carrier organic anion transporter family member; SLCO1B3-SLCO1B7 readthrough.
CDY2B protein networkhttps://string-db.org/network/9606.ENSP00000441273Chromodomain Y-linked 2B.
MARVELD1 protein networkhttps://string-db.org/network/9606.ENSP00000441365MARVEL domain-containing protein 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration.
PRKAB1 protein networkhttps://string-db.org/network/9606.ENSP000004413695'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy m [...]
MSLNL protein networkhttps://string-db.org/network/9606.ENSP00000441381Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family.
ZNF664 protein networkhttps://string-db.org/network/9606.ENSP00000441405Zinc finger protein 664; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF135 protein networkhttps://string-db.org/network/9606.ENSP00000441410Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-fin [...]
NNMT protein networkhttps://string-db.org/network/9606.ENSP00000441434Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenob [...]
UBC protein networkhttps://string-db.org/network/9606.ENSP00000441543Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either [...]
CCR3 protein networkhttps://string-db.org/network/9606.ENSP00000441600C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces [...]
TAS2R20 protein networkhttps://string-db.org/network/9606.ENSP00000441624Taste receptor type 2 member 20; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
PRR14 protein networkhttps://string-db.org/network/9606.ENSP00000441641Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. M [...]
PDZD9 protein networkhttps://string-db.org/network/9606.ENSP00000441685PDZ domain containing 9.
CLUL1 protein networkhttps://string-db.org/network/9606.ENSP00000441726Clusterin-like protein 1; Clusterin like 1.
DYRK4 protein networkhttps://string-db.org/network/9606.ENSP00000441755Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis.
PTHLH protein networkhttps://string-db.org/network/9606.ENSP00000441765Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calc [...]
CXorf56 protein networkhttps://string-db.org/network/9606.ENSP00000441786UPF0428 protein CXorf56; Chromosome X open reading frame 56.
PCDH7 protein networkhttps://string-db.org/network/9606.ENSP00000441802Protocadherin-7; Protocadherin 7.
SALL3 protein networkhttps://string-db.org/network/9606.ENSP00000441823Sal-like protein 3; Probable transcription factor.
HPR protein networkhttps://string-db.org/network/9606.ENSP00000441828Haptoglobin-related protein; Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic fac [...]
FNDC3A protein networkhttps://string-db.org/network/9606.ENSP00000441831Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family.
ZNF567 protein networkhttps://string-db.org/network/9606.ENSP00000441838Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
DMXL2 protein networkhttps://string-db.org/network/9606.ENSP00000441858DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By sim [...]
PHB2 protein networkhttps://string-db.org/network/9606.ENSP00000441875Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selecti [...]
ARHGEF28 protein networkhttps://string-db.org/network/9606.ENSP00000441913Rho guanine nucleotide exchange factor 28; Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Funct [...]
SESN3 protein networkhttps://string-db.org/network/9606.ENSP00000441927Sestrin-3; May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TO [...]
MUC12 protein networkhttps://string-db.org/network/9606.ENSP00000441929Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF-beta in i [...]
PIH1D3 protein networkhttps://string-db.org/network/9606.ENSP00000441930Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein. Belongs to the PIH1 family.
TAS2R14 protein networkhttps://string-db.org/network/9606.ENSP00000441949Taste receptor type 2 member 14; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
ORC4 protein networkhttps://string-db.org/network/9606.ENSP00000441953Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...]
SMAD5 protein networkhttps://string-db.org/network/9606.ENSP00000441954Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD).
CEPT1 protein networkhttps://string-db.org/network/9606.ENSP00000441980Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-de [...]
KIFC3 protein networkhttps://string-db.org/network/9606.ENSP00000442008Kinesin-like protein KIFC3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.
TMTC1 protein networkhttps://string-db.org/network/9606.ENSP00000442046Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated pr [...]
UTY protein networkhttps://string-db.org/network/9606.ENSP00000442047Histone demethylase UTY; Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity. Belongs to [...]
PCYT2 protein networkhttps://string-db.org/network/9606.ENSP00000442050Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP- ethanolamine.
RBM19 protein networkhttps://string-db.org/network/9606.ENSP00000442053Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development.
MAFF protein networkhttps://string-db.org/network/9606.ENSP00000442060Transcription factor MafF; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve [...]
CDCA3 protein networkhttps://string-db.org/network/9606.ENSP00000442068Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation [...]
HDGFL1 protein networkhttps://string-db.org/network/9606.ENSP00000442129Hepatoma-derived growth factor-like protein 1; HDGF like 1; Belongs to the HDGF family.
PIANP protein networkhttps://string-db.org/network/9606.ENSP00000442157PILR alpha-associated neural protein; Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.
MTRNR2L10 protein networkhttps://string-db.org/network/9606.ENSP00000442159Humanin-like 10; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
C12orf43 protein networkhttps://string-db.org/network/9606.ENSP00000442224Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development.
IQCC protein networkhttps://string-db.org/network/9606.ENSP00000442291IQ motif containing C.
ERFE protein networkhttps://string-db.org/network/9606.ENSP00000442304Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression [...]
ECT2L protein networkhttps://string-db.org/network/9606.ENSP00000442307Epithelial cell-transforming sequence 2 oncogene-like; May act as a guanine nucleotide exchange factor (GEF).
NKRF protein networkhttps://string-db.org/network/9606.ENSP00000442308NF-kappa-B-repressing factor; Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK- kappa-B responsive genes. Involved [...]
CAND1 protein networkhttps://string-db.org/network/9606.ENSP00000442318Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box su [...]
ZDHHC11B protein networkhttps://string-db.org/network/9606.ENSP00000442373Probable palmitoyltransferase ZDHHC11B; Zinc finger DHHC-type containing 11B.
SLC34A3 protein networkhttps://string-db.org/network/9606.ENSP00000442397Sodium-dependent phosphate transport protein 2C; May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% o [...]
KRTCAP3 protein networkhttps://string-db.org/network/9606.ENSP00000442400Keratinocyte associated protein 3.
IL22 protein networkhttps://string-db.org/network/9606.ENSP00000442424Interleukin-22; Cytokine that contributes to the inflammatory response in vivo.
MIXL1 protein networkhttps://string-db.org/network/9606.ENSP00000442439Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the pr [...]
PTK6 protein networkhttps://string-db.org/network/9606.ENSP00000442460Protein-tyrosine kinase 6; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epitheli [...]
NCEH1 protein networkhttps://string-db.org/network/9606.ENSP00000442464Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsibl [...]
ASIC5 protein networkhttps://string-db.org/network/9606.ENSP00000442477Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited [...]
STOML1 protein networkhttps://string-db.org/network/9606.ENSP00000442478Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current [...]
TTLL9 protein networkhttps://string-db.org/network/9606.ENSP00000442515Probable tubulin polyglutamylase TTLL9; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Acts when complexed with other proteins. By mediating tubulin polyglutamy [...]
BEX2 protein networkhttps://string-db.org/network/9606.ENSP00000442521Protein BEX2; Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the mod [...]
PODNL1 protein networkhttps://string-db.org/network/9606.ENSP00000442553Podocan-like protein 1; Podocan like 1.
POLG2 protein networkhttps://string-db.org/network/9606.ENSP00000442563DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. B [...]
ZNF668 protein networkhttps://string-db.org/network/9606.ENSP00000442573Zinc finger protein 668; May be involved in transcriptional regulation.
DAG1 protein networkhttps://string-db.org/network/9606.ENSP00000442600Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelinat [...]
PRB3 protein networkhttps://string-db.org/network/9606.ENSP00000442626Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum.
ACVR1B protein networkhttps://string-db.org/network/9606.ENSP00000442656Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin [...]
PTAFR protein networkhttps://string-db.org/network/9606.ENSP00000442658Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive act [...]
ADAP1 protein networkhttps://string-db.org/network/9606.ENSP00000442682Arf-GAP with dual PH domain-containing protein 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inosit [...]
MFSD5 protein networkhttps://string-db.org/network/9606.ENSP00000442688Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily.
HTATSF1 protein networkhttps://string-db.org/network/9606.ENSP00000442699HIV Tat-specific factor 1; Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on tr [...]
OR5AP2 protein networkhttps://string-db.org/network/9606.ENSP00000442701Olfactory receptor 5AP2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PLXNB3 protein networkhttps://string-db.org/network/9606.ENSP00000442736Plexin-B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In gliom [...]
FXYD6 protein networkhttps://string-db.org/network/9606.ENSP00000442756FXYD domain containing ion transport regulator 6.
GPN3 protein networkhttps://string-db.org/network/9606.ENSP00000442770GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.
LMO3 protein networkhttps://string-db.org/network/9606.ENSP00000442786LIM domain only 3.
TET2 protein networkhttps://string-db.org/network/9606.ENSP00000442788Methylcytosine dioxygenase TET2; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active D [...]
BEAN1 protein networkhttps://string-db.org/network/9606.ENSP00000442793Protein BEAN1; Brain expressed associated with NEDD4 1.
MYBPC3 protein networkhttps://string-db.org/network/9606.ENSP00000442795Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin [...]
RGS13 protein networkhttps://string-db.org/network/9606.ENSP00000442837Regulator of G-protein signaling 13; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to b [...]
SOD2-2 protein networkhttps://string-db.org/network/9606.ENSP00000442920Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
APC2 protein networkhttps://string-db.org/network/9606.ENSP00000442954Adenomatous polyposis coli protein 2; Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting t [...]
DAPK3 protein networkhttps://string-db.org/network/9606.ENSP00000442973Death-associated protein kinase 3; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved [...]
GPR17 protein networkhttps://string-db.org/network/9606.ENSP00000442982Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. Ma [...]
H4-16 protein networkhttps://string-db.org/network/9606.ENSP00000443017H4 histone 16.
RASSF3 protein networkhttps://string-db.org/network/9606.ENSP00000443021Ras association domain family member 3.
ZCCHC7 protein networkhttps://string-db.org/network/9606.ENSP00000443113Zinc finger CCHC-type containing 7.
F5H5T6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000443130Uncharacterized protein.
FAM180B protein networkhttps://string-db.org/network/9606.ENSP00000443133Protein FAM180B; Family with sequence similarity 180 member B.
STH protein networkhttps://string-db.org/network/9606.ENSP00000443168Saitohin.
RSPRY1 protein networkhttps://string-db.org/network/9606.ENSP00000443176Ring finger and SPRY domain containing 1.
NAT1 protein networkhttps://string-db.org/network/9606.ENSP00000443194Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine s [...]
C2CD5 protein networkhttps://string-db.org/network/9606.ENSP00000443204C2 domain-containing protein 5; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma [...]
TMEM258 protein networkhttps://string-db.org/network/9606.ENSP00000443216Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid car [...]
F5H5P2_HUMAN protein networkhttps://string-db.org/network/9606.ENSP000004432462-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple [...]
LPAR2 protein networkhttps://string-db.org/network/9606.ENSP00000443256Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of hete [...]
FAR2 protein networkhttps://string-db.org/network/9606.ENSP00000443291Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA subs [...]
FAM222A protein networkhttps://string-db.org/network/9606.ENSP00000443292Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family.
MTRNR2L3 protein networkhttps://string-db.org/network/9606.ENSP00000443339Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
TENT5D protein networkhttps://string-db.org/network/9606.ENSP00000443410Terminal nucleotidyltransferase 5D; Nucleotidyltransferase that act as a non-canonical poly(A) RNA polymerase; Belongs to the TENT family.
FAM92B protein networkhttps://string-db.org/network/9606.ENSP00000443411Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendag [...]
IDO2 protein networkhttps://string-db.org/network/9606.ENSP00000443432Indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May [...]
BCAT1 protein networkhttps://string-db.org/network/9606.ENSP00000443459Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
TUBA1C protein networkhttps://string-db.org/network/9606.ENSP00000443475Detyrosinated tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site [...]
FAM214A protein networkhttps://string-db.org/network/9606.ENSP00000443598Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family.
PLCB3 protein networkhttps://string-db.org/network/9606.ENSP000004436311-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...]
AUNIP protein networkhttps://string-db.org/network/9606.ENSP00000443647Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombinatio [...]
TBC1D10C protein networkhttps://string-db.org/network/9606.ENSP00000443654Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that als [...]
COA4 protein networkhttps://string-db.org/network/9606.ENSP00000443795Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Putative COX assembly factor; Belongs to the COA4 family.
ZNRF3 protein networkhttps://string-db.org/network/9606.ENSP00000443824E3 ubiquitin-protein ligase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt rec [...]
SP7 protein networkhttps://string-db.org/network/9606.ENSP00000443827Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
LYRM4 protein networkhttps://string-db.org/network/9606.ENSP00000443900LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family.
ZNF580 protein networkhttps://string-db.org/network/9606.ENSP00000443957Zinc finger protein 580; Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may p [...]
ADK protein networkhttps://string-db.org/network/9606.ENSP00000443965Adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular [...]
CPEB2 protein networkhttps://string-db.org/network/9606.ENSP00000443985Cytoplasmic polyadenylation element-binding protein 2; May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers [...]
SUDS3 protein networkhttps://string-db.org/network/9606.ENSP00000443988Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumo [...]
NUP153 protein networkhttps://string-db.org/network/9606.ENSP00000444029Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuc [...]
CES4A protein networkhttps://string-db.org/network/9606.ENSP00000444052Carboxylesterase 4A; Probable carboxylesterase.
OR52E8 protein networkhttps://string-db.org/network/9606.ENSP00000444054Olfactory receptor 52E8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MYO1H protein networkhttps://string-db.org/network/9606.ENSP00000444076Unconventional myosin-Ih; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...]
NPIPB3 protein networkhttps://string-db.org/network/9606.ENSP00000444096Nuclear pore complex interacting protein family member B3.
OR7G1 protein networkhttps://string-db.org/network/9606.ENSP00000444134Olfactory receptor 7G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
POLR1B protein networkhttps://string-db.org/network/9606.ENSP00000444136DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core [...]
SLCO1C1 protein networkhttps://string-db.org/network/9606.ENSP00000444149Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other pot [...]
ARMC6 protein networkhttps://string-db.org/network/9606.ENSP00000444156Armadillo repeat containing 6.
CITED2 protein networkhttps://string-db.org/network/9606.ENSP00000444198Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcrip [...]
SYT7 protein networkhttps://string-db.org/network/9606.ENSP00000444201Synaptotagmin-7; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces [...]
RAI2 protein networkhttps://string-db.org/network/9606.ENSP00000444210Retinoic acid induced 2.
PDGFRL protein networkhttps://string-db.org/network/9606.ENSP00000444211Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like.
TNFAIP8L1 protein networkhttps://string-db.org/network/9606.ENSP00000444215Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity. Belongs to the TNFAIP8 family.
C1R protein networkhttps://string-db.org/network/9606.ENSP00000444271Complement C1r subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs [...]
PRRG1 protein networkhttps://string-db.org/network/9606.ENSP00000444278Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1.
ZNF701 protein networkhttps://string-db.org/network/9606.ENSP00000444339Zinc finger protein 701; May be involved in transcriptional regulation.
OTUB1 protein networkhttps://string-db.org/network/9606.ENSP00000444357Ubiquitin thioesterase OTUB1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by [...]
SLC1A5 protein networkhttps://string-db.org/network/9606.ENSP00000444408Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all [...]
FRMPD1 protein networkhttps://string-db.org/network/9606.ENSP00000444411FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1.
ZNF268 protein networkhttps://string-db.org/network/9606.ENSP00000444412Zinc finger protein 268; [Isoform 1]: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and prog [...]
ADGRD1 protein networkhttps://string-db.org/network/9606.ENSP00000444425Adhesion G-protein coupled receptor D1; Orphan receptor. Signals via G(s)-alpha family of G-proteins. Has protumorigenic function especially in glioblastoma.
SCO2 protein networkhttps://string-db.org/network/9606.ENSP00000444433Protein SCO2 homolog, mitochondrial; Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu [...]
SEBOX protein networkhttps://string-db.org/network/9606.ENSP00000444503Homeobox protein SEBOX; Probable transcription factor involved in the control of specification of mesoderm and endoderm; Belongs to the paired homeobox family.
KRT86 protein networkhttps://string-db.org/network/9606.ENSP00000444533Keratin, type II cuticular Hb6.
ARMCX6 protein networkhttps://string-db.org/network/9606.ENSP00000444537Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Belongs to the eutherian X-chromosome-specific Armcx family.
TMEM14C protein networkhttps://string-db.org/network/9606.ENSP00000444561Transmembrane protein 14C; Required for normal heme biosynthesis.
TMUB2 protein networkhttps://string-db.org/network/9606.ENSP00000444565Transmembrane and ubiquitin like domain containing 2.
LOXHD1 protein networkhttps://string-db.org/network/9606.ENSP00000444586Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity).
MYCBP2 protein networkhttps://string-db.org/network/9606.ENSP00000444596E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating [...]
GLB1L2 protein networkhttps://string-db.org/network/9606.ENSP00000444628Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2.
YTHDF2 protein networkhttps://string-db.org/network/9606.ENSP00000444660YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites [...]
ATP1A3 protein networkhttps://string-db.org/network/9606.ENSP00000444688Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...]
TAS2R30 protein networkhttps://string-db.org/network/9606.ENSP00000444736Taste receptor type 2 member 30; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
SSH2 protein networkhttps://string-db.org/network/9606.ENSP00000444743Protein phosphatase Slingshot homolog 2; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequ [...]
ZNF835 protein networkhttps://string-db.org/network/9606.ENSP00000444747Zinc finger protein 835; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TDO2 protein networkhttps://string-db.org/network/9606.ENSP00000444788Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyze [...]
FKBP5 protein networkhttps://string-db.org/network/9606.ENSP00000444810Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-sho [...]
ZNF324 protein networkhttps://string-db.org/network/9606.ENSP00000444812Zinc finger protein 324A; May be involved in transcriptional regulation. May be involved in regulation of cell proliferation. Belongs to the krueppel C2H2-type zinc-finger protein family.
FXYD5 protein networkhttps://string-db.org/network/9606.ENSP00000444839FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family.
DENND5B protein networkhttps://string-db.org/network/9606.ENSP00000444889DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab protein [...]
NUTM1 protein networkhttps://string-db.org/network/9606.ENSP00000444896NUT family member 1; Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
PAFAH1B3 protein networkhttps://string-db.org/network/9606.ENSP00000444935Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the dev [...]
INTS11 protein networkhttps://string-db.org/network/9606.ENSP00000445001Integrator complex subunit 11; Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent proc [...]
APOA5 protein networkhttps://string-db.org/network/9606.ENSP00000445002Apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) l [...]
FRY protein networkhttps://string-db.org/network/9606.ENSP00000445043Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in earl [...]
HSD3B2 protein networkhttps://string-db.org/network/9606.ENSP000004451223 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxid [...]
NLRP2 protein networkhttps://string-db.org/network/9606.ENSP00000445135NACHT, LRR and PYD domains-containing protein 2; Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated [...]
GTF2H3 protein networkhttps://string-db.org/network/9606.ENSP00000445162General transcription factor IIH subunit 3; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotid [...]
LDHA protein networkhttps://string-db.org/network/9606.ENSP00000445175Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family.
PRR19 protein networkhttps://string-db.org/network/9606.ENSP00000445247Proline-rich protein 19; Proline rich 19.
PTX4 protein networkhttps://string-db.org/network/9606.ENSP00000445277Pentraxin-4; Pentraxin 4.
ZDHHC11B-2 protein networkhttps://string-db.org/network/9606.ENSP00000445280Zinc finger DHHC-type containing 11B.
ATP1A1 protein networkhttps://string-db.org/network/9606.ENSP00000445306Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...]
ZNF559-ZNF177 protein networkhttps://string-db.org/network/9606.ENSP00000445323ZNF559-ZNF177 readthrough.
SLC5A8 protein networkhttps://string-db.org/network/9606.ENSP00000445340Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (shor [...]
DND1 protein networkhttps://string-db.org/network/9606.ENSP00000445366Dead end protein homolog 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity [...]
PIK3C2G protein networkhttps://string-db.org/network/9606.ENSP00000445381Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that [...]
OR10G2 protein networkhttps://string-db.org/network/9606.ENSP00000445383Olfactory receptor 10G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RABEP1 protein networkhttps://string-db.org/network/9606.ENSP00000445408Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling en [...]
FAM90A1 protein networkhttps://string-db.org/network/9606.ENSP00000445418Protein FAM90A1; Family with sequence similarity 90 member A1.
PHKG1 protein networkhttps://string-db.org/network/9606.ENSP00000445440Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen b [...]
ST8SIA5 protein networkhttps://string-db.org/network/9606.ENSP00000445492Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively. Belongs to the glycosyltransferase 29 family.
CNOT4 protein networkhttps://string-db.org/network/9606.ENSP00000445508CCR4-NOT transcription complex subunit 4; Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes [...]
KCNS1 protein networkhttps://string-db.org/network/9606.ENSP00000445595Potassium voltage-gated channel subfamily S member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB [...]
ASB8 protein networkhttps://string-db.org/network/9606.ENSP00000445622Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
EGR4 protein networkhttps://string-db.org/network/9606.ENSP00000445626Early growth response protein 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required [...]
H2BC8 protein networkhttps://string-db.org/network/9606.ENSP00000445633H2B clustered histone 8.
PRAME protein networkhttps://string-db.org/network/9606.ENSP00000445675Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. P [...]
ANKRD65 protein networkhttps://string-db.org/network/9606.ENSP00000445688Ankyrin repeat domain 65.
RNF170 protein networkhttps://string-db.org/network/9606.ENSP00000445725E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradatio [...]
NELFA protein networkhttps://string-db.org/network/9606.ENSP00000445757Negative elongation factor A; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...]
DENND11 protein networkhttps://string-db.org/network/9606.ENSP00000445768DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bou [...]
LTB4R2 protein networkhttps://string-db.org/network/9606.ENSP00000445772Leukotriene B4 receptor 2; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activ [...]
FAM216B protein networkhttps://string-db.org/network/9606.ENSP00000445786Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family.
TIMM50 protein networkhttps://string-db.org/network/9606.ENSP00000445806Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across th [...]
SLC39A11 protein networkhttps://string-db.org/network/9606.ENSP00000445829Zinc transporter ZIP11; Functions as a cellular zinc transporter.
H2BC18 protein networkhttps://string-db.org/network/9606.ENSP00000445831Histone H2B type 2-F; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
BCL7A protein networkhttps://string-db.org/network/9606.ENSP00000445868B-cell CLL/lymphoma 7 protein family member A; BAF chromatin remodeling complex subunit BCL7A.
EVI5L protein networkhttps://string-db.org/network/9606.ENSP00000445905EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity.
MMAB protein networkhttps://string-db.org/network/9606.ENSP00000445920Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer t [...]
SLC2A14 protein networkhttps://string-db.org/network/9606.ENSP00000445929Solute carrier family 2, facilitated glucose transporter member 14; Hexose transporter that can mediate the transport of glucose and dehydroascorbate across the cell membrane.
ZNF623 protein networkhttps://string-db.org/network/9606.ENSP00000445979Zinc finger protein 623; May be involved in transcriptional regulation.
VIM protein networkhttps://string-db.org/network/9606.ENSP00000446007Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitoc [...]
COPS7A protein networkhttps://string-db.org/network/9606.ENSP00000446039COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...]
BEX5 protein networkhttps://string-db.org/network/9606.ENSP00000446054Protein BEX5; Brain expressed X-linked 5; Belongs to the BEX family.
SHD protein networkhttps://string-db.org/network/9606.ENSP00000446058SH2 domain-containing adapter protein D; May function as an adapter protein.
TUBGCP2 protein networkhttps://string-db.org/network/9606.ENSP00000446093Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
RBMXL1 protein networkhttps://string-db.org/network/9606.ENSP00000446099RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing.
CMIP protein networkhttps://string-db.org/network/9606.ENSP00000446100C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that [...]
C12orf56 protein networkhttps://string-db.org/network/9606.ENSP00000446101Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56.
RRP12 protein networkhttps://string-db.org/network/9606.ENSP00000446184RRP12-like protein; Ribosomal RNA processing 12 homolog.
HES7 protein networkhttps://string-db.org/network/9606.ENSP00000446205Transcription factor HES-7; Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the preso [...]
RAN protein networkhttps://string-db.org/network/9606.ENSP00000446215GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplas [...]
ZNF550 protein networkhttps://string-db.org/network/9606.ENSP00000446224Zinc finger protein 550; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SLC25A10 protein networkhttps://string-db.org/network/9606.ENSP00000446242Mitochondrial dicarboxylate carrier; Solute carrier family 25 member 10; Belongs to the mitochondrial carrier (TC 2.A.29) family.
SOD2 protein networkhttps://string-db.org/network/9606.ENSP00000446252Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese [...]
LSM14A protein networkhttps://string-db.org/network/9606.ENSP00000446271Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs.
LRTM2 protein networkhttps://string-db.org/network/9606.ENSP00000446278Leucine rich repeats and transmembrane domains 2.
PCSK5 protein networkhttps://string-db.org/network/9606.ENSP00000446280Proprotein convertase subtilisin/kexin type 5; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...]
ZNF362 protein networkhttps://string-db.org/network/9606.ENSP00000446335Zinc finger protein 362; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GCSAML protein networkhttps://string-db.org/network/9606.ENSP00000446460Germinal center associated signaling and motility like.
FICD protein networkhttps://string-db.org/network/9606.ENSP00000446479Protein adenylyltransferase FICD; Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same [...]
GTSF1 protein networkhttps://string-db.org/network/9606.ENSP00000446485Gametocyte-specific factor 1; Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells. Belongs to the UPF0224 (FAM112) family.
ATXN2 protein networkhttps://string-db.org/network/9606.ENSP00000446576Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
HOXC11 protein networkhttps://string-db.org/network/9606.ENSP00000446680Homeobox protein Hox-C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...]
PCED1B protein networkhttps://string-db.org/network/9606.ENSP00000446688PC-esterase domain containing 1B; Belongs to the PC-esterase family.
F8W031_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000446743DUF3456 domain-containing protein.
BPNT1 protein networkhttps://string-db.org/network/9606.ENSP000004468283'(2'),5'-bisphosphate nucleotidase 1; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 10 [...]
DNAJC22 protein networkhttps://string-db.org/network/9606.ENSP00000446830DnaJ homolog subfamily C member 22; May function as a co-chaperone.
GATC protein networkhttps://string-db.org/network/9606.ENSP00000446872Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...]
BAZ2A protein networkhttps://string-db.org/network/9606.ENSP00000446880Bromodomain adjacent to zinc finger domain protein 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruitin [...]
NPIPA2 protein networkhttps://string-db.org/network/9606.ENSP00000446882Nuclear pore complex interacting protein family member A2; Belongs to the NPIP family.
NPIPB9 protein networkhttps://string-db.org/network/9606.ENSP00000446902Nuclear pore complex interacting protein family member B9; Belongs to the NPIP family.
PRSS58 protein networkhttps://string-db.org/network/9606.ENSP00000446916Serine protease 58; Belongs to the peptidase S1 family.
APPL2 protein networkhttps://string-db.org/network/9606.ENSP00000446917DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell prolifer [...]
MYL6 protein networkhttps://string-db.org/network/9606.ENSP00000446955Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium.
H0YHG0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000447000Uncharacterized protein.
RPL18 protein networkhttps://string-db.org/network/9606.ENSP0000044700160S ribosomal protein L18; Component of the large ribosomal subunit.
CNTN1 protein networkhttps://string-db.org/network/9606.ENSP00000447006Contactin-1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the [...]
RAB5C protein networkhttps://string-db.org/network/9606.ENSP00000447053Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
F8W1H4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000447056Uncharacterized protein.
C12orf45 protein networkhttps://string-db.org/network/9606.ENSP00000447057Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45.
SLC8B1 protein networkhttps://string-db.org/network/9606.ENSP00000447091Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium io [...]
C12orf54 protein networkhttps://string-db.org/network/9606.ENSP00000447109Uncharacterized protein C12orf54; Chromosome 12 open reading frame 54.
CHURC1-FNTB protein networkhttps://string-db.org/network/9606.ENSP00000447121Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth p [...]
NR1H4 protein networkhttps://string-db.org/network/9606.ENSP00000447149Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). [...]
OTOGL protein networkhttps://string-db.org/network/9606.ENSP00000447211Otogelin-like protein; Otogelin like.
FRS2 protein networkhttps://string-db.org/network/9606.ENSP00000447241Fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinase [...]
TGFBR1 protein networkhttps://string-db.org/network/9606.ENSP00000447297TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokin [...]
RAB3IP protein networkhttps://string-db.org/network/9606.ENSP00000447300Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their [...]
MGAM protein networkhttps://string-db.org/network/9606.ENSP00000447378Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique ro [...]
LIN7A protein networkhttps://string-db.org/network/9606.ENSP00000447488Protein lin-7 homolog A; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...]
BLOC1S1 protein networkhttps://string-db.org/network/9606.ENSP00000447537Biogenesis of lysosome-related organelles complex 1 subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
NPIPB12 protein networkhttps://string-db.org/network/9606.ENSP00000447597Nuclear pore complex interacting protein family member B12.
MTERF2 protein networkhttps://string-db.org/network/9606.ENSP00000447651Transcription termination factor 2, mitochondrial; Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species. Belongs to the mTERF family.
INAFM1 protein networkhttps://string-db.org/network/9606.ENSP00000447679Putative transmembrane protein INAFM1; InaF motif containing 1.
CD63 protein networkhttps://string-db.org/network/9606.ENSP00000447730CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leadi [...]
TMEM116 protein networkhttps://string-db.org/network/9606.ENSP00000447731Transmembrane protein 116.
POC1B-GALNT4 protein networkhttps://string-db.org/network/9606.ENSP00000447852Polypeptide N-acetylgalactosaminyltransferase; POC1B-GALNT4 readthrough.
ZBED6 protein networkhttps://string-db.org/network/9606.ENSP00000447879Zinc finger BED domain-containing protein 6; Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of othe [...]
ZNF878 protein networkhttps://string-db.org/network/9606.ENSP00000447931Zinc finger protein 878; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PFDN5 protein networkhttps://string-db.org/network/9606.ENSP00000447942Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...]
CEP290 protein networkhttps://string-db.org/network/9606.ENSP00000448012Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role i [...]
NACA protein networkhttps://string-db.org/network/9606.ENSP00000448035Nascent polypeptide associated complex subunit alpha.
WSCD2 protein networkhttps://string-db.org/network/9606.ENSP00000448047WSC domain containing 2; Belongs to the WSCD family.
DAZAP2 protein networkhttps://string-db.org/network/9606.ENSP00000448051DAZ associated protein 2.
NUP37 protein networkhttps://string-db.org/network/9606.ENSP00000448054Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex [...]
PAH protein networkhttps://string-db.org/network/9606.ENSP00000448059Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
POTEM protein networkhttps://string-db.org/network/9606.ENSP00000448062POTE ankyrin domain family member M; Belongs to the POTE family.
SLC16A7 protein networkhttps://string-db.org/network/9606.ENSP00000448071Monocarboxylate transporter 2; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-ch [...]
PRPF40B protein networkhttps://string-db.org/network/9606.ENSP00000448073Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing.
TPCN1 protein networkhttps://string-db.org/network/9606.ENSP00000448083Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal [...]
APAF1 protein networkhttps://string-db.org/network/9606.ENSP00000448165Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apopto [...]
TBC1D15 protein networkhttps://string-db.org/network/9606.ENSP00000448182TBC1 domain family member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).
TAS2R38 protein networkhttps://string-db.org/network/9606.ENSP00000448219Taste receptor type 2 member 38; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...]
KRT4 protein networkhttps://string-db.org/network/9606.ENSP00000448220Keratin, type II cytoskeletal 4; Keratin 4; Belongs to the intermediate filament family.
SPATS2 protein networkhttps://string-db.org/network/9606.ENSP00000448228Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2.
GLIPR1L2 protein networkhttps://string-db.org/network/9606.ENSP00000448248GLIPR1-like protein 2; GLIPR1 like 2; Belongs to the CRISP family.
BEST2 protein networkhttps://string-db.org/network/9606.ENSP00000448310Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
BRF1 protein networkhttps://string-db.org/network/9606.ENSP00000448387Transcription factor IIIB 90 kDa subunit; General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transc [...]
IKZF4 protein networkhttps://string-db.org/network/9606.ENSP00000448419Zinc finger protein Eos; DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros- binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTS [...]
C12orf75 protein networkhttps://string-db.org/network/9606.ENSP00000448536Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75.
SPIC protein networkhttps://string-db.org/network/9606.ENSP00000448580Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-r [...]
C17orf49 protein networkhttps://string-db.org/network/9606.ENSP00000448598Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes.
DDIT3 protein networkhttps://string-db.org/network/9606.ENSP00000448665DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell [...]
RITA1 protein networkhttps://string-db.org/network/9606.ENSP00000448680RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediate [...]
DTX3 protein networkhttps://string-db.org/network/9606.ENSP00000448696Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Prob [...]
MYRFL protein networkhttps://string-db.org/network/9606.ENSP00000448753Myelin regulatory factor like.
METTL7A protein networkhttps://string-db.org/network/9606.ENSP00000448785Methyltransferase-like protein 7A; Probable methyltransferase.
OR6C68 protein networkhttps://string-db.org/network/9606.ENSP00000448811Olfactory receptor 6C68; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
NPIPA3 protein networkhttps://string-db.org/network/9606.ENSP00000448841Nuclear pore complex interacting protein family member A3.
GAS2L3 protein networkhttps://string-db.org/network/9606.ENSP00000448955GAS2-like protein 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network. Belongs to the GAS2 family.
CYP4F12 protein networkhttps://string-db.org/network/9606.ENSP00000448998Cytochrome P450 4F12; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs). Mechanistically, uses molecular oxygen inserting one oxygen ato [...]
OR11H12 protein networkhttps://string-db.org/network/9606.ENSP00000449002Olfactory receptor 11H12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RPL41 protein networkhttps://string-db.org/network/9606.ENSP00000449026Ribosomal protein L41.
MAP3K12 protein networkhttps://string-db.org/network/9606.ENSP00000449038Mitogen-activated protein kinase kinase kinase 12; Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal tran [...]
RDH12 protein networkhttps://string-db.org/network/9606.ENSP00000449079Retinol dehydrogenase 12; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity towards [...]
DNM1L protein networkhttps://string-db.org/network/9606.ENSP00000449089Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the sci [...]
C19orf67 protein networkhttps://string-db.org/network/9606.ENSP00000449137UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family.
AGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000449241Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the preve [...]
KCNC2 protein networkhttps://string-db.org/network/9606.ENSP00000449253Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes t [...]
COPZ1 protein networkhttps://string-db.org/network/9606.ENSP00000449270Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosyn [...]
RPLP0 protein networkhttps://string-db.org/network/9606.ENSP0000044932860S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
MAPKAPK5 protein networkhttps://string-db.org/network/9606.ENSP00000449381MAP kinase-activated protein kinase 5; Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MA [...]
SART3 protein networkhttps://string-db.org/network/9606.ENSP00000449386Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRN [...]
SMARCC2 protein networkhttps://string-db.org/network/9606.ENSP00000449396SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chroma [...]
KRT8 protein networkhttps://string-db.org/network/9606.ENSP00000449404Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. Belongs to the intermediate filament family.
TWF1 protein networkhttps://string-db.org/network/9606.ENSP00000449428Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also [...]
RNASEK protein networkhttps://string-db.org/network/9606.ENSP00000449500Ribonuclease kappa; Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.
ACSS3 protein networkhttps://string-db.org/network/9606.ENSP00000449535Acyl-CoA synthetase short-chain family member 3, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Propionate is the preferred substrate. Can utilize acetate and [...]
H0YIJ7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000449544Uncharacterized protein.
ANKS1B protein networkhttps://string-db.org/network/9606.ENSP00000449629Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. Is [...]
CMKLR1 protein networkhttps://string-db.org/network/9606.ENSP00000449716Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of [...]
FKBP11 protein networkhttps://string-db.org/network/9606.ENSP00000449751Peptidyl-prolyl cis-trans isomerase FKBP11; PPIases accelerate the folding of proteins during protein synthesis.
SLC38A1 protein networkhttps://string-db.org/network/9606.ENSP00000449756Sodium-coupled neutral amino acid transporter 1; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium [...]
H0YIN7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000449770Peptidase_M24 domain-containing protein.
TMEM263 protein networkhttps://string-db.org/network/9606.ENSP00000449785Transmembrane protein 263.
TRIAP1 protein networkhttps://string-db.org/network/9606.ENSP00000449795TP53-regulated inhibitor of apoptosis 1; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, t [...]
MRPL42 protein networkhttps://string-db.org/network/9606.ENSP00000449884Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family.
CALCOCO1 protein networkhttps://string-db.org/network/9606.ENSP00000449960Calcium-binding and coiled-coil domain-containing protein 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N- ter [...]
CLEC5A protein networkhttps://string-db.org/network/9606.ENSP00000449999C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (B [...]
ASPG protein networkhttps://string-db.org/network/9606.ENSP000004500401-alkyl-2-acetylglycerophosphocholine esterase; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylati [...]
H0YIS7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000450085RNASEK-C17orf49 readthrough.
CLBA1 protein networkhttps://string-db.org/network/9606.ENSP00000450114Uncharacterized protein CLBA1; Clathrin binding box of aftiphilin containing 1.
RASAL1 protein networkhttps://string-db.org/network/9606.ENSP00000450244RasGAP-activating-like protein 1; Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
H0YIV9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000450281Uncharacterized protein.
GPR84 protein networkhttps://string-db.org/network/9606.ENSP00000450310G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the [...]
PPFIA2 protein networkhttps://string-db.org/network/9606.ENSP00000450337Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at speci [...]
F8VP50_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000450353Aldedh domain-containing protein.
MYL6B protein networkhttps://string-db.org/network/9606.ENSP00000450385Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium.
ALDH6A1 protein networkhttps://string-db.org/network/9606.ENSP00000450436Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA; Belongs to the aldehyde dehydrogenase family.
HEATR4 protein networkhttps://string-db.org/network/9606.ENSP00000450444HEAT repeat containing 4.
RAX2 protein networkhttps://string-db.org/network/9606.ENSP00000450456Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promote [...]
CEP95 protein networkhttps://string-db.org/network/9606.ENSP00000450461Centrosomal protein 95.
ATP10A protein networkhttps://string-db.org/network/9606.ENSP00000450480Probable phospholipid-transporting ATPase VA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...]
BDKRB2 protein networkhttps://string-db.org/network/9606.ENSP00000450482B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 [...]
MAP1LC3B2 protein networkhttps://string-db.org/network/9606.ENSP00000450524Microtubule-associated proteins 1A/1B light chain 3 beta 2; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes [...]
HOPX protein networkhttps://string-db.org/network/9606.ENSP00000450527Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating th [...]
SERPINA3 protein networkhttps://string-db.org/network/9606.ENSP00000450540Alpha-1-antichymotrypsin His-Pro-less; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the [...]
IL11RA protein networkhttps://string-db.org/network/9606.ENSP00000450565Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11R [...]
RPS6KL1 protein networkhttps://string-db.org/network/9606.ENSP00000450567Ribosomal protein S6 kinase like 1.
RNASE12 protein networkhttps://string-db.org/network/9606.ENSP00000450580Probable inactive ribonuclease-like protein 12; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family.
ETFRF1 protein networkhttps://string-db.org/network/9606.ENSP00000450584Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB [...]
TIMELESS protein networkhttps://string-db.org/network/9606.ENSP00000450607Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, [...]
VTI1B protein networkhttps://string-db.org/network/9606.ENSP00000450731Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are [...]
ZFYVE1 protein networkhttps://string-db.org/network/9606.ENSP00000450742Zinc finger FYVE-type containing 1.
JKAMP protein networkhttps://string-db.org/network/9606.ENSP00000450749JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) [...]
KHNYN protein networkhttps://string-db.org/network/9606.ENSP00000450799Protein KHNYN; KH and NYN domain containing.
SIPA1L1 protein networkhttps://string-db.org/network/9606.ENSP00000450832Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to t [...]
TMEM30B protein networkhttps://string-db.org/network/9606.ENSP00000450842Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inne [...]
POTEG protein networkhttps://string-db.org/network/9606.ENSP00000450853POTE ankyrin domain family member G.
G3V2T6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000450856Uncharacterized protein.
STON2 protein networkhttps://string-db.org/network/9606.ENSP00000450857Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family.
PPP4R3A protein networkhttps://string-db.org/network/9606.ENSP00000450864Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizin [...]
H0YJ60_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000450870Uncharacterized protein.
ACYP1 protein networkhttps://string-db.org/network/9606.ENSP00000450873Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family.
FPGT-TNNI3K protein networkhttps://string-db.org/network/9606.ENSP00000450895FPGT-TNNI3K readthrough.
SLIRP protein networkhttps://string-db.org/network/9606.ENSP00000450909SRA stem-loop-interacting RNA-binding protein, mitochondrial; RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediate [...]
TMEM179 protein networkhttps://string-db.org/network/9606.ENSP00000450958Transmembrane protein 179; Belongs to the TMEM179 family.
EMX2 protein networkhttps://string-db.org/network/9606.ENSP00000450962Homeobox protein EMX2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations [...]
ZBTB33 protein networkhttps://string-db.org/network/9606.ENSP00000450969Transcriptional regulator Kaiso; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the n [...]
ZBTB1 protein networkhttps://string-db.org/network/9606.ENSP00000451000Zinc finger and BTB domain-containing protein 1; Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in trans [...]
RGS6 protein networkhttps://string-db.org/network/9606.ENSP00000451030Regulator of G-protein signaling 6; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...]
PGF protein networkhttps://string-db.org/network/9606.ENSP00000451040Placenta growth factor; Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 bind [...]
ERH protein networkhttps://string-db.org/network/9606.ENSP00000451080Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family.
SNW1 protein networkhttps://string-db.org/network/9606.ENSP00000451129SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruit [...]
PINX1-2 protein networkhttps://string-db.org/network/9606.ENSP00000451145Uncharacterized protein; PIN2 interacting telomerase inhibitor 1.
CEP128 protein networkhttps://string-db.org/network/9606.ENSP00000451162Centrosomal protein 128.
SERPINA4 protein networkhttps://string-db.org/network/9606.ENSP00000451172Kallistatin; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor an [...]
GSKIP protein networkhttps://string-db.org/network/9606.ENSP00000451188GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signali [...]
NPC2 protein networkhttps://string-db.org/network/9606.ENSP00000451206NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal comp [...]
NEDD1 protein networkhttps://string-db.org/network/9606.ENSP00000451211Protein NEDD1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle.
PROX2 protein networkhttps://string-db.org/network/9606.ENSP00000451223Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity). Belongs to the Prospero homeodomain family.
UBE2J1 protein networkhttps://string-db.org/network/9606.ENSP00000451261Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic re [...]
MAP3K9 protein networkhttps://string-db.org/network/9606.ENSP00000451263Mitogen-activated protein kinase kinase kinase 9; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...]
HNRNPC protein networkhttps://string-db.org/network/9606.ENSP00000451291Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the st [...]
NUMB protein networkhttps://string-db.org/network/9606.ENSP00000451300Protein numb homolog; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowi [...]
RNASE11 protein networkhttps://string-db.org/network/9606.ENSP00000451318Ribonuclease A family member 11.
HSD17B6 protein networkhttps://string-db.org/network/9606.ENSP0000045140617-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid [...]
DIO2 protein networkhttps://string-db.org/network/9606.ENSP00000451419Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate leve [...]
TCL1A protein networkhttps://string-db.org/network/9606.ENSP00000451506T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondr [...]
ENSP00000451560 protein networkhttps://string-db.org/network/9606.ENSP00000451560G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the tubulin family.
ASB2 protein networkhttps://string-db.org/network/9606.ENSP00000451575Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination a [...]
DMAC2L protein networkhttps://string-db.org/network/9606.ENSP00000451583ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP syn [...]
MOAP1 protein networkhttps://string-db.org/network/9606.ENSP00000451594Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response [...]
MC1R protein networkhttps://string-db.org/network/9606.ENSP00000451605Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to th [...]
NDRG2 protein networkhttps://string-db.org/network/9606.ENSP00000451712Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor s [...]
G3V4G9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000451792Ig-like domain-containing protein.
LIN52 protein networkhttps://string-db.org/network/9606.ENSP00000451812Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component.
SRP54 protein networkhttps://string-db.org/network/9606.ENSP00000451818Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating me [...]
AKT1 protein networkhttps://string-db.org/network/9606.ENSP00000451828RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includi [...]
SMIM13 protein networkhttps://string-db.org/network/9606.ENSP00000451866Small integral membrane protein 13.
PRAF2 protein networkhttps://string-db.org/network/9606.ENSP00000451962PRA1 family protein 2; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis. Belongs to the PRA1 family.
XRCC3 protein networkhttps://string-db.org/network/9606.ENSP00000451974DNA repair protein XRCC3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of [...]
GSTZ1 protein networkhttps://string-db.org/network/9606.ENSP00000451976Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3- diazole and maleylacetoacetate isomeras [...]
EML5 protein networkhttps://string-db.org/network/9606.ENSP00000451998Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
ISCA2 protein networkhttps://string-db.org/network/9606.ENSP00000452007Iron-sulfur cluster assembly 2 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in [...]
DNAL1 protein networkhttps://string-db.org/network/9606.ENSP00000452037Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm [...]
SLC35F4 protein networkhttps://string-db.org/network/9606.ENSP00000452086Solute carrier family 35 member F4; Putative solute transporter.
ITGA7 protein networkhttps://string-db.org/network/9606.ENSP00000452120Integrin alpha-7 70 kDa form; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shap [...]
SRSF5 protein networkhttps://string-db.org/network/9606.ENSP00000452123Serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites; Belongs to the splicing factor SR family.
RGMA protein networkhttps://string-db.org/network/9606.ENSP00000452126Repulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube cl [...]
VIPAS39 protein networkhttps://string-db.org/network/9606.ENSP00000452181Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the ap [...]
RNASE4 protein networkhttps://string-db.org/network/9606.ENSP00000452245Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family.
OR4C13 protein networkhttps://string-db.org/network/9606.ENSP00000452277Olfactory receptor 4C13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PTGR2 protein networkhttps://string-db.org/network/9606.ENSP00000452280Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-P [...]
H0YJW9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000452347Uncharacterized protein.
DUXA protein networkhttps://string-db.org/network/9606.ENSP00000452398Double homeobox protein A; Putative transcription factor; Belongs to the paired homeobox family.
PTPN21 protein networkhttps://string-db.org/network/9606.ENSP00000452414Protein tyrosine phosphatase non-receptor type 21.
GTF2A1 protein networkhttps://string-db.org/network/9606.ENSP00000452454Transcription initiation factor IIA alpha chain; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a com [...]
BCL2L2-PABPN1 protein networkhttps://string-db.org/network/9606.ENSP00000452479Polyadenylate-binding protein 2; BCL2L2-PABPN1 readthrough.
NAA30 protein networkhttps://string-db.org/network/9606.ENSP00000452521N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Le [...]
SOCS4 protein networkhttps://string-db.org/network/9606.ENSP00000452522Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate- recognition component of a SCF-l [...]
SAMD4A protein networkhttps://string-db.org/network/9606.ENSP00000452535Protein Smaug homolog 1; Acts as a translational repressor of SRE-containing messengers; Belongs to the SMAUG family.
E7ENQ6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000452549YjeF N-terminal domain-containing protein.
ZFP37 protein networkhttps://string-db.org/network/9606.ENSP00000452552Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TNFAIP2 protein networkhttps://string-db.org/network/9606.ENSP00000452634Tumor necrosis factor alpha-induced protein 2; May play a role as a mediator of inflammation and angiogenesis.
IGKV2D-28 protein networkhttps://string-db.org/network/9606.ENSP00000452662Immunoglobulin kappa variable 2-28; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
SEC11A protein networkhttps://string-db.org/network/9606.ENSP00000452697SEC11 homolog A, signal peptidase complex subunit.
PSTPIP1 protein networkhttps://string-db.org/network/9606.ENSP00000452746Proline-serine-threonine phosphatase-interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PT [...]
IGKV2D-40 protein networkhttps://string-db.org/network/9606.ENSP00000452747Immunoglobulin kappa variable 2-40; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
ETFA protein networkhttps://string-db.org/network/9606.ENSP00000452762Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehy [...]
RPL28 protein networkhttps://string-db.org/network/9606.ENSP0000045276360S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family.
CCDC32 protein networkhttps://string-db.org/network/9606.ENSP00000452773Coiled-coil domain containing 32.
ITGB3 protein networkhttps://string-db.org/network/9606.ENSP00000452786Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitr [...]
GDPGP1 protein networkhttps://string-db.org/network/9606.ENSP00000452793GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.
PEAK1 protein networkhttps://string-db.org/network/9606.ENSP00000452796Inactive tyrosine-protein kinase PEAK1; Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adh [...]
TLE3 protein networkhttps://string-db.org/network/9606.ENSP00000452871Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members [...]
ZNF592 protein networkhttps://string-db.org/network/9606.ENSP00000452877Zinc finger protein 592; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MINDY2 protein networkhttps://string-db.org/network/9606.ENSP00000452885Ubiquitin carboxyl-terminal hydrolase MINDY-2; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Binds to polyubiquitin chains of different linkage types, including 'L [...]
MAN2A2 protein networkhttps://string-db.org/network/9606.ENSP00000452948Alpha-mannosidase 2x; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N [...]
UBE2Q2L protein networkhttps://string-db.org/network/9606.ENSP00000453012Putative ubiquitin-conjugating enzyme E2Q2-like protein; Ubiquitin conjugating enzyme E2 Q2 like; Belongs to the ubiquitin-conjugating enzyme family.
RNF111 protein networkhttps://string-db.org/network/9606.ENSP00000453015E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional respons [...]
TMEM250 protein networkhttps://string-db.org/network/9606.ENSP00000453019Transmembrane protein 250; May play a role in cell proliferation by promoting progression into S phase.
ZNF280D-2 protein networkhttps://string-db.org/network/9606.ENSP00000453045Zinc finger protein 280D.
GPR176 protein networkhttps://string-db.org/network/9606.ENSP00000453076G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist- independent basal activity to repr [...]
H0YL77_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000453089Uncharacterized protein.
MEF2A protein networkhttps://string-db.org/network/9606.ENSP00000453095Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the act [...]
GALK2 protein networkhttps://string-db.org/network/9606.ENSP00000453129N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free Gal [...]
BLID protein networkhttps://string-db.org/network/9606.ENSP00000453153BH3-like motif-containing cell death inducer; Functions as a proapoptotic molecule through the caspase- dependent mitochondrial pathway of cell death.
RGPD1 protein networkhttps://string-db.org/network/9606.ENSP00000453170RANBP2 like and GRIP domain containing 1.
TRIM69 protein networkhttps://string-db.org/network/9606.ENSP00000453177E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.
LRRC49 protein networkhttps://string-db.org/network/9606.ENSP00000453273Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49.
APBA2 protein networkhttps://string-db.org/network/9606.ENSP00000453293Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machi [...]
ADAM8 protein networkhttps://string-db.org/network/9606.ENSP00000453302Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes.
MEIS3 protein networkhttps://string-db.org/network/9606.ENSP00000453307Homeobox protein Meis3; Transcriptional regulator which directly modulates PDPK1 expression, thus promoting survival of pancreatic beta-cells. Also regulates expression of NDFIP1, BNIP3, and CCNG [...]
TMEM185B protein networkhttps://string-db.org/network/9606.ENSP00000453399Transmembrane protein 185B.
ST20 protein networkhttps://string-db.org/network/9606.ENSP00000453502Suppressor of tumorigenicity 20 protein; May act as a tumor suppressor. Promotes apoptosis of cancer cells.
TLN2 protein networkhttps://string-db.org/network/9606.ENSP00000453508Talin-2; As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and [...]
BCL2L10 protein networkhttps://string-db.org/network/9606.ENSP00000453562Bcl-2-like protein 10; Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.
TGIF2LX protein networkhttps://string-db.org/network/9606.ENSP00000453704Homeobox protein TGIF2LX; May have a transcription role in testis.
TGIF2LY protein networkhttps://string-db.org/network/9606.ENSP00000453750Homeobox protein TGIF2LY; May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX; Belongs to the TALE/TGIF homeobox family.
MEIS2 protein networkhttps://string-db.org/network/9606.ENSP00000453793Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabiliz [...]
WDR61 protein networkhttps://string-db.org/network/9606.ENSP00000453801WD repeat-containing protein 61, N-terminally processed; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulati [...]
SECISBP2L protein networkhttps://string-db.org/network/9606.ENSP00000453854Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into [...]
PAK6 protein networkhttps://string-db.org/network/9606.ENSP00000453858Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR [...]
CCDC175 protein networkhttps://string-db.org/network/9606.ENSP00000453940Coiled-coil domain containing 175.
TMEM253 protein networkhttps://string-db.org/network/9606.ENSP00000453962Transmembrane protein 253.
CCDC9B protein networkhttps://string-db.org/network/9606.ENSP00000453969Coiled-coil domain containing 9B.
UBAP1L protein networkhttps://string-db.org/network/9606.ENSP00000454012Ubiquitin-associated protein 1-like; Ubiquitin associated protein 1 like.
SHISA9 protein networkhttps://string-db.org/network/9606.ENSP00000454014Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA re [...]
TGIF2-RAB5IF protein networkhttps://string-db.org/network/9606.ENSP00000454021Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes.
GMPR2 protein networkhttps://string-db.org/network/9606.ENSP00000454038GMP reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, a [...]
NRL protein networkhttps://string-db.org/network/9606.ENSP00000454062Neural retina-specific leucine zipper protein; Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a trans [...]
LDLR protein networkhttps://string-db.org/network/9606.ENSP00000454071Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand co [...]
C5orf63 protein networkhttps://string-db.org/network/9606.ENSP00000454153Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63.
CLN3 protein networkhttps://string-db.org/network/9606.ENSP00000454229Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes.
NUB1 protein networkhttps://string-db.org/network/9606.ENSP00000454264NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation o [...]
MINAR2 protein networkhttps://string-db.org/network/9606.ENSP00000454268Major intrinsically disordered NOTCH2-binding receptor 1-like; Membrane integral NOTCH2 associated receptor 2.
AP5B1 protein networkhttps://string-db.org/network/9606.ENSP00000454303AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.
GOLGA8F protein networkhttps://string-db.org/network/9606.ENSP00000454322Golgin A8 family member F; Belongs to the GOLGA8 family.
MPV17L-2 protein networkhttps://string-db.org/network/9606.ENSP00000454340Mpv17-like protein; Belongs to the peroxisomal membrane protein PXMP2/4 family.
ARPP19 protein networkhttps://string-db.org/network/9606.ENSP00000454341cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically [...]
SMKR1 protein networkhttps://string-db.org/network/9606.ENSP00000454370Small lysine rich protein 1.
ANTKMT protein networkhttps://string-db.org/network/9606.ENSP00000454380Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, there [...]
TMEM170A protein networkhttps://string-db.org/network/9606.ENSP00000454404Transmembrane protein 170A; Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet format [...]
GOLGA6L2 protein networkhttps://string-db.org/network/9606.ENSP00000454407Golgin subfamily A member 6-like protein 2; Golgin A6 family like 2; Belongs to the GOLGA6 family.
H3BML4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000454437Ig-like domain-containing protein.
TMEM249 protein networkhttps://string-db.org/network/9606.ENSP00000454468Transmembrane protein 249.
H3BMQ9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000454500Uncharacterized protein.
RBM15B protein networkhttps://string-db.org/network/9606.ENSP00000454545Putative RNA-binding protein 15B; RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative sp [...]
C8orf88 protein networkhttps://string-db.org/network/9606.ENSP00000454561Uncharacterized protein C8orf88; Chromosome 8 open reading frame 88.
DNASE1L2 protein networkhttps://string-db.org/network/9606.ENSP00000454562Deoxyribonuclease-1-like 2; Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune rol [...]
ITGAX protein networkhttps://string-db.org/network/9606.ENSP00000454623Integrin alpha-X; Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is espe [...]
SLC38A7 protein networkhttps://string-db.org/network/9606.ENSP00000454646Putative sodium-coupled neutral amino acid transporter 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine; Belongs to the amino acid/polyamine transporter 2 family.
H3BN98_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000454746Uncharacterized protein.
ANKRD66 protein networkhttps://string-db.org/network/9606.ENSP00000454770Ankyrin repeat domain 66.
H3BNC9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000454786Uncharacterized protein.
ASIP protein networkhttps://string-db.org/network/9606.ENSP00000454804Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-reg [...]
TBL3 protein networkhttps://string-db.org/network/9606.ENSP00000454836Transducin beta like 3.
SNUPN protein networkhttps://string-db.org/network/9606.ENSP00000454852Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-ca [...]
C3orf84 protein networkhttps://string-db.org/network/9606.ENSP00000454903Uncharacterized protein C3orf84; Chromosome 3 open reading frame 84.
ARMH2 protein networkhttps://string-db.org/network/9606.ENSP00000454913Armadillo-like helical domain-containing protein 2; Armadillo like helical domain containing 2.
RNF112 protein networkhttps://string-db.org/network/9606.ENSP00000454919RING finger protein 112; E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic d [...]
MOSMO protein networkhttps://string-db.org/network/9606.ENSP00000454926Modulator of smoothened protein; Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the cil [...]
TMEM204 protein networkhttps://string-db.org/network/9606.ENSP00000454945Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.
SCAPER protein networkhttps://string-db.org/network/9606.ENSP00000454973S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm.
RPUSD1 protein networkhttps://string-db.org/network/9606.ENSP00000455026RNA pseudouridine synthase domain containing 1; Belongs to the pseudouridine synthase RluA family.
TMC7 protein networkhttps://string-db.org/network/9606.ENSP00000455041Transmembrane channel-like protein 7; Probable ion channel.
H3BNX3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000455047Pyr_redox_2 domain-containing protein.
SLC7A6 protein networkhttps://string-db.org/network/9606.ENSP00000455064Y+L amino acid transporter 2; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to [...]
METRN protein networkhttps://string-db.org/network/9606.ENSP00000455068Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. A [...]
C16orf95 protein networkhttps://string-db.org/network/9606.ENSP00000455079Uncharacterized protein C16orf95; Chromosome 16 open reading frame 95.
TMEM88B protein networkhttps://string-db.org/network/9606.ENSP00000455099Transmembrane protein 88B.
BOP1 protein networkhttps://string-db.org/network/9606.ENSP00000455106Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ [...]
HEXA protein networkhttps://string-db.org/network/9606.ENSP00000455114Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. [...]
TP53TG3C protein networkhttps://string-db.org/network/9606.ENSP00000455132TP53 target 3C.
ENSP00000455145 protein networkhttps://string-db.org/network/9606.ENSP00000455145Novel protein.
NETO2 protein networkhttps://string-db.org/network/9606.ENSP00000455169Neuropilin and tolloid-like protein 2; Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetic [...]
ADGRG1 protein networkhttps://string-db.org/network/9606.ENSP00000455215Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells [...]
DUS2 protein networkhttps://string-db.org/network/9606.ENSP00000455229tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively [...]
TAF1C protein networkhttps://string-db.org/network/9606.ENSP00000455265TATA box-binding protein-associated factor RNA polymerase I subunit C; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation comple [...]
GOLGA8S protein networkhttps://string-db.org/network/9606.ENSP00000455298Golgin A8 family member S; Belongs to the GOLGA8 family.
ZNF598 protein networkhttps://string-db.org/network/9606.ENSP00000455308E3 ubiquitin-protein ligase ZNF598; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translat [...]
MKRN2OS protein networkhttps://string-db.org/network/9606.ENSP00000455385MKRN2 opposite strand.
ZNF423 protein networkhttps://string-db.org/network/9606.ENSP00000455426Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associat [...]
RD3L protein networkhttps://string-db.org/network/9606.ENSP00000455434Protein RD3-like; Retinal degeneration 3 like.
NUPR2 protein networkhttps://string-db.org/network/9606.ENSP00000455442Nuclear protein 2; Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, an [...]
TCF24 protein networkhttps://string-db.org/network/9606.ENSP00000455444Transcription factor 24; Putative transcription factor.
GJE1 protein networkhttps://string-db.org/network/9606.ENSP00000455469Putative gap junction epsilon-1 protein; Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions. Belongs to the connexin family. Be [...]
OBSCN protein networkhttps://string-db.org/network/9606.ENSP00000455507Obscurin; Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle. Has serine/thr [...]
AMDHD2-2 protein networkhttps://string-db.org/network/9606.ENSP00000455561Uncharacterized protein.
DOK4 protein networkhttps://string-db.org/network/9606.ENSP00000455566Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in [...]
ZNF853 protein networkhttps://string-db.org/network/9606.ENSP00000455585Zinc finger protein 853.
TP53TG3D protein networkhttps://string-db.org/network/9606.ENSP00000455596TP53 target 3D.
PHKG2 protein networkhttps://string-db.org/network/9606.ENSP00000455607Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown [...]
ST20-MTHFS protein networkhttps://string-db.org/network/9606.ENSP000004556435-formyltetrahydrofolate cyclo-ligase; ST20-MTHFS readthrough; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
STMND1 protein networkhttps://string-db.org/network/9606.ENSP00000455698Stathmin domain containing 1.
SCRT1 protein networkhttps://string-db.org/network/9606.ENSP00000455711Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal [...]
OST4 protein networkhttps://string-db.org/network/9606.ENSP00000455716Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Ma [...]
TMSB15B protein networkhttps://string-db.org/network/9606.ENSP00000455771Thymosin beta 15B.
KCTD13 protein networkhttps://string-db.org/network/9606.ENSP00000455785BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic trans [...]
DYNLRB2 protein networkhttps://string-db.org/network/9606.ENSP00000455791Dynein light chain roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and [...]
LY6L protein networkhttps://string-db.org/network/9606.ENSP00000455811Lymphocyte antigen 6 family member L.
DDX19B protein networkhttps://string-db.org/network/9606.ENSP00000455813ATP-dependent RNA helicase DDX19B; DEAD-box helicase 19B.
GOLGA8T protein networkhttps://string-db.org/network/9606.ENSP00000455826Golgin A8 family member T; Belongs to the GOLGA8 family.
TEX38 protein networkhttps://string-db.org/network/9606.ENSP00000455854Testis-expressed protein 38; Testis expressed 38.
MRC1 protein networkhttps://string-db.org/network/9606.ENSP00000455897Macrophage mannose receptor 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as a receptor for D [...]
MUC22 protein networkhttps://string-db.org/network/9606.ENSP00000455906Mucin-22; Mucin 22.
FAM229A protein networkhttps://string-db.org/network/9606.ENSP00000455971Protein FAM229A; Family with sequence similarity 229 member A; Belongs to the FAM229 family.
SQOR protein networkhttps://string-db.org/network/9606.ENSP00000456019Sulfide:quinone oxidoreductase, mitochondrial; Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (mo [...]
SMLR1 protein networkhttps://string-db.org/network/9606.ENSP00000456026Small leucine rich protein 1.
TUBB8 protein networkhttps://string-db.org/network/9606.ENSP00000456206Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...]
EARS2 protein networkhttps://string-db.org/network/9606.ENSP00000456218Probable glutamate--tRNA ligase, mitochondrial; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferre [...]
PRRT2 protein networkhttps://string-db.org/network/9606.ENSP00000456226Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presyna [...]
ADAL protein networkhttps://string-db.org/network/9606.ENSP00000456242Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. [...]
TMEM210 protein networkhttps://string-db.org/network/9606.ENSP00000456333Transmembrane protein 210.
C15orf65 protein networkhttps://string-db.org/network/9606.ENSP00000456337Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65.
DET1 protein networkhttps://string-db.org/network/9606.ENSP00000456340DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiqui [...]
PARP6 protein networkhttps://string-db.org/network/9606.ENSP00000456348Protein mono-ADP-ribosyltransferase PARP6; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins.
GOLGA8J protein networkhttps://string-db.org/network/9606.ENSP00000456401Golgin A8 family member J; Belongs to the GOLGA8 family.
CNN2 protein networkhttps://string-db.org/network/9606.ENSP00000456436Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...]
C15orf41 protein networkhttps://string-db.org/network/9606.ENSP00000456477Protein C15orf41; Plays a role in erythroid cell differentiation.
SNX29 protein networkhttps://string-db.org/network/9606.ENSP00000456480Sorting nexin 29.
ZNF469 protein networkhttps://string-db.org/network/9606.ENSP00000456500Zinc finger protein 469; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CCDC187 protein networkhttps://string-db.org/network/9606.ENSP00000456543Coiled-coil domain containing 187.
ELFN1 protein networkhttps://string-db.org/network/9606.ENSP00000456548Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitator [...]
RNF151 protein networkhttps://string-db.org/network/9606.ENSP00000456566RING finger protein 151; May be involved in acrosome formation of spermatids.
TMEM178B protein networkhttps://string-db.org/network/9606.ENSP00000456594Transmembrane protein 178B.
STRA6 protein networkhttps://string-db.org/network/9606.ENSP00000456609Receptor for retinol uptake STRA6; Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell m [...]
KLHL36 protein networkhttps://string-db.org/network/9606.ENSP00000456743Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
ZDHHC7 protein networkhttps://string-db.org/network/9606.ENSP00000456782Palmitoyltransferase ZDHHC7; Palmitoyltransferase with broad specificity. Palmitoylates JAM3. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, inc [...]
THEGL protein networkhttps://string-db.org/network/9606.ENSP00000456850Testicular haploid expressed gene protein-like; Theg spermatid protein like.
BLOC1S6 protein networkhttps://string-db.org/network/9606.ENSP00000456851Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...]
TBC1D3G protein networkhttps://string-db.org/network/9606.ENSP00000456861TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
LOC100509620 protein networkhttps://string-db.org/network/9606.ENSP00000456868Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.
GOLGA8H protein networkhttps://string-db.org/network/9606.ENSP00000456894Golgin A8 family member H; Belongs to the GOLGA8 family.
CTU2 protein networkhttps://string-db.org/network/9606.ENSP00000456908Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with [...]
WFDC1 protein networkhttps://string-db.org/network/9606.ENSP00000456920WAP four-disulfide core domain protein 1; Has growth inhibitory activity.
GOLGA8M protein networkhttps://string-db.org/network/9606.ENSP00000456927Golgin A8 family member M.
POTEB2 protein networkhttps://string-db.org/network/9606.ENSP00000456953POTE ankyrin domain family member B2; Belongs to the POTE family.
NPW protein networkhttps://string-db.org/network/9606.ENSP00000456974Neuropeptide W-23; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the [...]
INO80E protein networkhttps://string-db.org/network/9606.ENSP00000457016INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
ZFP1 protein networkhttps://string-db.org/network/9606.ENSP00000457044Zinc finger protein 1 homolog; May be involved in transcriptional regulation.
IRS4-2 protein networkhttps://string-db.org/network/9606.ENSP00000457111Insulin receptor substrate 4.
SZT2 protein networkhttps://string-db.org/network/9606.ENSP00000457168KICSTOR complex protein SZT2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 [...]
HAPLN3 protein networkhttps://string-db.org/network/9606.ENSP00000457180Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding.
INSYN1 protein networkhttps://string-db.org/network/9606.ENSP00000457205Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyper [...]
SPSB3 protein networkhttps://string-db.org/network/9606.ENSP00000457206SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the u [...]
WWOX protein networkhttps://string-db.org/network/9606.ENSP00000457230WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergis [...]
TSNAXIP1 protein networkhttps://string-db.org/network/9606.ENSP00000457241Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis.
NOL3 protein networkhttps://string-db.org/network/9606.ENSP00000457243Nucleolar protein 3; [Isoform 1]: May be involved in RNA splicing.
OGFOD1 protein networkhttps://string-db.org/network/9606.ENSP00000457258Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficienc [...]
ZNF747 protein networkhttps://string-db.org/network/9606.ENSP00000457274KRAB domain-containing protein ZNF747; Zinc finger protein 747.
EME2 protein networkhttps://string-db.org/network/9606.ENSP00000457353Probable crossover junction endonuclease EME2; Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
CEMP1 protein networkhttps://string-db.org/network/9606.ENSP00000457380Cementoblastoma-derived protein 1; May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the period [...]
SMIM1 protein networkhttps://string-db.org/network/9606.ENSP00000457386Small integral membrane protein 1; Regulator of red blood cell formation. Belongs to the SMIM1 family.
KIAA0513 protein networkhttps://string-db.org/network/9606.ENSP00000457408Uncharacterized protein KIAA0513; KIAA0513.
USP10 protein networkhttps://string-db.org/network/9606.ENSP00000457411Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 st [...]
PECAM1 protein networkhttps://string-db.org/network/9606.ENSP00000457421Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical r [...]
TMEM219 protein networkhttps://string-db.org/network/9606.ENSP00000457492Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding.
CCDC179 protein networkhttps://string-db.org/network/9606.ENSP00000457511Coiled-coil domain containing 179.
COX4I1 protein networkhttps://string-db.org/network/9606.ENSP00000457513Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylatio [...]
APOBR protein networkhttps://string-db.org/network/9606.ENSP00000457539Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic [...]
DBNDD1 protein networkhttps://string-db.org/network/9606.ENSP00000457625Dysbindin domain containing 1.
H3BUI4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000457654Uncharacterized protein.
POTEB protein networkhttps://string-db.org/network/9606.ENSP00000457689POTE ankyrin domain family member B.
UBL7 protein networkhttps://string-db.org/network/9606.ENSP00000457703Ubiquitin-like protein 7; Ubiquitin like 7.
ENSP00000457704 protein networkhttps://string-db.org/network/9606.ENSP00000457704Uncharacterized protein.
ZNF865 protein networkhttps://string-db.org/network/9606.ENSP00000457715Zinc finger protein 865; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
H3BUN2_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000457718Uncharacterized protein.
RNPS1 protein networkhttps://string-db.org/network/9606.ENSP00000457723RNA-binding protein with serine-rich domain 1; Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) d [...]
TRAPPC2L protein networkhttps://string-db.org/network/9606.ENSP00000457728Trafficking protein particle complex subunit 2-like protein; Plays a role in vesicular transport from endoplasmic reticulum to Golgi.
SLC25A24 protein networkhttps://string-db.org/network/9606.ENSP00000457733Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, [...]
RGSL1 protein networkhttps://string-db.org/network/9606.ENSP00000457748Regulator of G protein signaling like 1.
MAN2C1 protein networkhttps://string-db.org/network/9606.ENSP00000457788Alpha-mannosidase 2C1; Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm; Belongs to [...]
KCNJ18 protein networkhttps://string-db.org/network/9606.ENSP00000457807Inward rectifier potassium channel 18; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...]
CENPT protein networkhttps://string-db.org/network/9606.ENSP00000457810Centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...]
MLST8 protein networkhttps://string-db.org/network/9606.ENSP00000457870Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response [...]
GOLGA8Q protein networkhttps://string-db.org/network/9606.ENSP00000457904Golgin A8 family member Q; Belongs to the GOLGA8 family.
TGFBR3L protein networkhttps://string-db.org/network/9606.ENSP00000457962Transforming growth factor-beta receptor type 3-like protein; Transforming growth factor beta receptor 3 like.
PHLPP2 protein networkhttps://string-db.org/network/9606.ENSP00000457991PH domain leucine-rich repeat-containing protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobi [...]
HSPB9 protein networkhttps://string-db.org/network/9606.ENSP00000458018Heat shock protein family B member 9.
PMF1-BGLAP protein networkhttps://string-db.org/network/9606.ENSP00000458021PMF1-BGLAP readthrough.
DUX4 protein networkhttps://string-db.org/network/9606.ENSP00000458065Double homeobox protein 4-like protein 2; May be involved in transcriptional regulation.
BOLA2-SMG1P6 protein networkhttps://string-db.org/network/9606.ENSP00000458075BOLA2-SMG1P6 readthrough.
GOLGA8G protein networkhttps://string-db.org/network/9606.ENSP00000458130Golgin A8 family member G.
ACTG1 protein networkhttps://string-db.org/network/9606.ENSP00000458162Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
METTL4 protein networkhttps://string-db.org/network/9606.ENSP00000458290N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is requ [...]
INCA1 protein networkhttps://string-db.org/network/9606.ENSP00000458316Protein INCA1; Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation [...]
DNAH2 protein networkhttps://string-db.org/network/9606.ENSP00000458355Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
CTRL protein networkhttps://string-db.org/network/9606.ENSP00000458537Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.
PCDHGA4 protein networkhttps://string-db.org/network/9606.ENSP00000458570Protocadherin gamma-A4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
MMP12 protein networkhttps://string-db.org/network/9606.ENSP00000458585Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for [...]
CIC protein networkhttps://string-db.org/network/9606.ENSP00000458663Protein capicua homolog; Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development.
NMRAL1 protein networkhttps://string-db.org/network/9606.ENSP00000458762NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NAD [...]
NDUFAB1 protein networkhttps://string-db.org/network/9606.ENSP00000458770Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respirat [...]
GPR139 protein networkhttps://string-db.org/network/9606.ENSP00000458791Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway.
ZSCAN10 protein networkhttps://string-db.org/network/9606.ENSP00000458879Zinc finger and SCAN domain-containing protein 10; Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression o [...]
NUP88 protein networkhttps://string-db.org/network/9606.ENSP00000458954Nuclear pore complex protein Nup88; Component of nuclear pore complex.
DPEP2 protein networkhttps://string-db.org/network/9606.ENSP00000458977Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).
CLUH protein networkhttps://string-db.org/network/9606.ENSP00000458986Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in th [...]
PLSCR3 protein networkhttps://string-db.org/network/9606.ENSP00000459019Phospholipid scramblase 3; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...]
OR1D5 protein networkhttps://string-db.org/network/9606.ENSP00000459028Olfactory receptor 1D5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
BICDL2 protein networkhttps://string-db.org/network/9606.ENSP00000459043BICD family like cargo adaptor 2.
ZNF578 protein networkhttps://string-db.org/network/9606.ENSP00000459216Zinc finger protein 578; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GFY protein networkhttps://string-db.org/network/9606.ENSP00000459439Golgi-associated olfactory signaling regulator; Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity).
ACSM2A protein networkhttps://string-db.org/network/9606.ENSP00000459451Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activa [...]
LITAF protein networkhttps://string-db.org/network/9606.ENSP00000459533Lipopolysaccharide-induced tumor necrosis factor-alpha factor; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocyt [...]
LRRC37A2 protein networkhttps://string-db.org/network/9606.ENSP00000459551Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2.
ZNF75A protein networkhttps://string-db.org/network/9606.ENSP00000459566Zinc finger protein 75A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SPATA22 protein networkhttps://string-db.org/network/9606.ENSP00000459580Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I.
SRGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000459615SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Play [...]
MRTFB protein networkhttps://string-db.org/network/9606.ENSP00000459626Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation.
TNK1 protein networkhttps://string-db.org/network/9606.ENSP00000459799Non-receptor tyrosine-protein kinase TNK1; Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function [...]
ANKFY1 protein networkhttps://string-db.org/network/9606.ENSP00000459943Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin [...]
TRPV1 protein networkhttps://string-db.org/network/9606.ENSP00000459962Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. See [...]
GTF2I protein networkhttps://string-db.org/network/9606.ENSP00000460070General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal resp [...]
SPON1 protein networkhttps://string-db.org/network/9606.ENSP00000460236Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in [...]
PCDHGA9 protein networkhttps://string-db.org/network/9606.ENSP00000460274Protocadherin gamma-A9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PRPF8 protein networkhttps://string-db.org/network/9606.ENSP00000460348Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type splic [...]
OCLM protein networkhttps://string-db.org/network/9606.ENSP00000460371Oculomedin.
USP6 protein networkhttps://string-db.org/network/9606.ENSP00000460380Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In v [...]
PCTP protein networkhttps://string-db.org/network/9606.ENSP00000460437Phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule.
NLRP1 protein networkhttps://string-db.org/network/9606.ENSP00000460475NACHT, LRR and PYD domains-containing protein 1; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...]
ARL17B protein networkhttps://string-db.org/network/9606.ENSP00000460539ADP-ribosylation factor-like protein 17; ADP ribosylation factor like GTPase 17B.
ZFP90 protein networkhttps://string-db.org/network/9606.ENSP00000460547Zinc finger protein 90 homolog; Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes.
ERVMER34-1 protein networkhttps://string-db.org/network/9606.ENSP00000460602Endogenous retroviral envelope protein HEMO, secreted form; Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during [...]
CCER2 protein networkhttps://string-db.org/network/9606.ENSP00000460665Coiled-coil glutamate rich protein 2.
CTDNEP1 protein networkhttps://string-db.org/network/9606.ENSP00000460683CTD nuclear envelope phosphatase 1; Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 [...]
TOM1L1 protein networkhttps://string-db.org/network/9606.ENSP00000460823TOM1-like protein 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activ [...]
WSCD1 protein networkhttps://string-db.org/network/9606.ENSP00000460825WSC domain containing 1.
RSL1D1 protein networkhttps://string-db.org/network/9606.ENSP00000460871Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the univers [...]
CORO7-PAM16 protein networkhttps://string-db.org/network/9606.ENSP00000460885Coronin; CORO7-PAM16 readthrough; Belongs to the WD repeat coronin family.
ATPAF1 protein networkhttps://string-db.org/network/9606.ENSP00000460964ATP synthase mitochondrial F1 complex assembly factor 1; May play an essential role for the assembly of the mitochondrial F1-F0 complex.
ZP2 protein networkhttps://string-db.org/network/9606.ENSP00000460971Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and [...]
ZNF594 protein networkhttps://string-db.org/network/9606.ENSP00000461032Zinc finger protein 594; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SCIMP protein networkhttps://string-db.org/network/9606.ENSP00000461269SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune [...]
I3L4J1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000461295Uncharacterized protein; Belongs to the AAA ATPase family.
SLC25A10-2 protein networkhttps://string-db.org/network/9606.ENSP00000461324Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
SLC43A2 protein networkhttps://string-db.org/network/9606.ENSP00000461382Large neutral amino acids transporter small subunit 4; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids.
OVCA2 protein networkhttps://string-db.org/network/9606.ENSP00000461388OVCA2 serine hydrolase domain containing; Belongs to the LovG family.
ZNF66 protein networkhttps://string-db.org/network/9606.ENSP00000461425Putative zinc finger protein 66; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MCRIP1 protein networkhttps://string-db.org/network/9606.ENSP00000461433Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds [...]
GOSR2 protein networkhttps://string-db.org/network/9606.ENSP00000461784Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network; Belongs to the GOSR2 family.
RAB40B protein networkhttps://string-db.org/network/9606.ENSP00000461785Ras-related protein Rab-40B; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...]
FOPNL protein networkhttps://string-db.org/network/9606.ENSP00000461830LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitment of PLK1 to centrosomes and S phase progression.
PCDHGB3 protein networkhttps://string-db.org/network/9606.ENSP00000461862Protocadherin gamma-B3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
ENSP00000461865 protein networkhttps://string-db.org/network/9606.ENSP00000461865Novel protein.
POLR2A protein networkhttps://string-db.org/network/9606.ENSP00000461879DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and cataly [...]
MRPS21 protein networkhttps://string-db.org/network/9606.ENSP00000461930Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family.
RAB31 protein networkhttps://string-db.org/network/9606.ENSP00000461945Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...]
CD226 protein networkhttps://string-db.org/network/9606.ENSP00000461947CD226 antigen; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NEC [...]
PIRT protein networkhttps://string-db.org/network/9606.ENSP00000462046Phosphoinositide-interacting protein; Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisph [...]
ZFP92 protein networkhttps://string-db.org/network/9606.ENSP00000462054Zinc finger protein 92 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RASSF5 protein networkhttps://string-db.org/network/9606.ENSP00000462099Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to i [...]
SMIM21 protein networkhttps://string-db.org/network/9606.ENSP00000462106Small integral membrane protein 21.
SAP30BP protein networkhttps://string-db.org/network/9606.ENSP00000462116SAP30-binding protein; Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes; Belongs to [...]
BAHCC1 protein networkhttps://string-db.org/network/9606.ENSP00000462154BAH domain and coiled-coil containing 1.
KIAA0040 protein networkhttps://string-db.org/network/9606.ENSP00000462172Uncharacterized protein KIAA0040; KIAA0040.
AKAIN1 protein networkhttps://string-db.org/network/9606.ENSP00000462259A-kinase anchor protein inhibitor 1; Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A- kinase anchoring protein (AKAP)-me [...]
ZNF488 protein networkhttps://string-db.org/network/9606.ENSP00000462269Zinc finger protein 488; Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling- activated formation of oligodendrocyte precurso [...]
NOTCH2NLC protein networkhttps://string-db.org/network/9606.ENSP00000462298Notch 2 N-terminal like C.
CD300LF protein networkhttps://string-db.org/network/9606.ENSP00000462309CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recog [...]
ENGASE protein networkhttps://string-db.org/network/9606.ENSP00000462333Cytosolic endo-beta-N-acetylglucosaminidase; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in t [...]
VEZF1 protein networkhttps://string-db.org/network/9606.ENSP00000462337Vascular endothelial zinc finger 1; Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3; Belongs to t [...]
STARD6 protein networkhttps://string-db.org/network/9606.ENSP00000462349StAR-related lipid transfer protein 6; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).
H4C15 protein networkhttps://string-db.org/network/9606.ENSP00000462355H4 clustered histone 15.
FAM222B protein networkhttps://string-db.org/network/9606.ENSP00000462419Protein FAM222B; Family with sequence similarity 222 member B; Belongs to the FAM222 family.
TPPP3 protein networkhttps://string-db.org/network/9606.ENSP00000462435Tubulin polymerization-promoting protein family member 3; Regulator of microtubule dynamic that has microtubule bundling activity. Required for embryo implantation; possibly by regulating beta-ca [...]
YES1 protein networkhttps://string-db.org/network/9606.ENSP00000462468Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and diffe [...]
TXNIP protein networkhttps://string-db.org/network/9606.ENSP00000462521Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced sup [...]
NBPF15 protein networkhttps://string-db.org/network/9606.ENSP00000462600Neuroblastoma breakpoint family member 15; NBPF member 15.
ADCYAP1 protein networkhttps://string-db.org/network/9606.ENSP00000462647Pituitary adenylate cyclase-activating polypeptide 27; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development thr [...]
POLI protein networkhttps://string-db.org/network/9606.ENSP00000462664DNA polymerase iota; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot procee [...]
H4C14 protein networkhttps://string-db.org/network/9606.ENSP00000462667H4 clustered histone 14.
CDH8 protein networkhttps://string-db.org/network/9606.ENSP00000462701Cadherin-8; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
CUEDC1 protein networkhttps://string-db.org/network/9606.ENSP00000462717CUE domain containing 1.
OTUD7B protein networkhttps://string-db.org/network/9606.ENSP00000462729OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acti [...]
DCAF8L2 protein networkhttps://string-db.org/network/9606.ENSP00000462745DDB1- and CUL4-associated factor 8-like protein 2; DDB1 and CUL4 associated factor 8 like 2; Belongs to the WD repeat DCAF8 family.
NAT9 protein networkhttps://string-db.org/network/9606.ENSP00000462835N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily.
MSL1 protein networkhttps://string-db.org/network/9606.ENSP00000462945Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of [...]
TEFM protein networkhttps://string-db.org/network/9606.ENSP00000462963Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, inc [...]
TAF4B protein networkhttps://string-db.org/network/9606.ENSP00000462980Transcription initiation factor TFIID subunit 4B; Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is [...]
SPATA33 protein networkhttps://string-db.org/network/9606.ENSP00000462996Spermatogenesis-associated protein 33; Spermatogenesis associated 33.
MIEN1 protein networkhttps://string-db.org/network/9606.ENSP00000462998Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through contr [...]
OAZ2 protein networkhttps://string-db.org/network/9606.ENSP00000463013Ornithine decarboxylase antizyme 2; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...]
NCOA4 protein networkhttps://string-db.org/network/9606.ENSP00000463027Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor [...]
FAM72C protein networkhttps://string-db.org/network/9606.ENSP00000463032Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family.
GDF2 protein networkhttps://string-db.org/network/9606.ENSP00000463051Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells [...]
PPIAL4C protein networkhttps://string-db.org/network/9606.ENSP00000463057Peptidyl-prolyl cis-trans isomerase A-like 4C; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...]
RBM8A protein networkhttps://string-db.org/network/9606.ENSP00000463058RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junct [...]
RNF43 protein networkhttps://string-db.org/network/9606.ENSP00000463069E3 ubiquitin-protein ligase RNF43; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradati [...]
MARCHF10 protein networkhttps://string-db.org/network/9606.ENSP00000463080Probable E3 ubiquitin-protein ligase MARCHF10; E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and [...]
MSMB protein networkhttps://string-db.org/network/9606.ENSP00000463092Beta-microseminoprotein; Microseminoprotein beta.
RBP3 protein networkhttps://string-db.org/network/9606.ENSP00000463151Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
ANP32E protein networkhttps://string-db.org/network/9606.ENSP00000463154Acidic leucine-rich nuclear phosphoprotein 32 family member E; Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 [...]
C19orf47 protein networkhttps://string-db.org/network/9606.ENSP00000463159Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47.
SNURF protein networkhttps://string-db.org/network/9606.ENSP00000463201SNRPN upstream reading frame.
PABPC4L protein networkhttps://string-db.org/network/9606.ENSP00000463233Polyadenylate-binding protein 4-like; May bind RNA.
TMEM98 protein networkhttps://string-db.org/network/9606.ENSP00000463245Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-f [...]
CCDC178 protein networkhttps://string-db.org/network/9606.ENSP00000463254Coiled-coil domain containing 178.
KLF14 protein networkhttps://string-db.org/network/9606.ENSP00000463287Kruppel like factor 14.
PTPRM protein networkhttps://string-db.org/network/9606.ENSP00000463325Receptor-type tyrosine-protein phosphatase mu; Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.
MIF4GD protein networkhttps://string-db.org/network/9606.ENSP00000463334MIF4G domain-containing protein; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loo [...]
SMIM6 protein networkhttps://string-db.org/network/9606.ENSP00000463361Small integral membrane protein 6.
TMEM200C protein networkhttps://string-db.org/network/9606.ENSP00000463375Transmembrane protein 200C.
RPL17-C18orf32 protein networkhttps://string-db.org/network/9606.ENSP00000463379RPL17-C18orf32 readthrough; Belongs to the universal ribosomal protein uL22 family.
SEC22B protein networkhttps://string-db.org/network/9606.ENSP00000463393Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the [...]
PPIAL4E protein networkhttps://string-db.org/network/9606.ENSP00000463419Peptidyl-prolyl cis-trans isomerase A-like 4E; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...]
KCNH6 protein networkhttps://string-db.org/network/9606.ENSP00000463533Potassium voltage-gated channel subfamily H member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel pro [...]
MYL12B protein networkhttps://string-db.org/network/9606.ENSP00000463559Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phos [...]
ACP6 protein networkhttps://string-db.org/network/9606.ENSP00000463574Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysop [...]
RNF115 protein networkhttps://string-db.org/network/9606.ENSP00000463650E3 ubiquitin-protein ligase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biolo [...]
RBFOX3 protein networkhttps://string-db.org/network/9606.ENSP00000463653RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-med [...]
GJD3 protein networkhttps://string-db.org/network/9606.ENSP00000463752Gap junction delta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
TERB1 protein networkhttps://string-db.org/network/9606.ENSP00000463762Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homolo [...]
KCNJ12 protein networkhttps://string-db.org/network/9606.ENSP00000463778ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling t [...]
RPL26 protein networkhttps://string-db.org/network/9606.ENSP0000046378460S ribosomal protein L26; Component of the large ribosomal subunit.
RPL17 protein networkhttps://string-db.org/network/9606.ENSP0000046384260S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family.
ARHGDIA protein networkhttps://string-db.org/network/9606.ENSP00000463939Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequen [...]
NBPF10 protein networkhttps://string-db.org/network/9606.ENSP00000463957Neuroblastoma breakpoint family member 10; NBPF member 10.
SLC16A3 protein networkhttps://string-db.org/network/9606.ENSP00000463978Monocarboxylate transporter 4; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...]
YTHDC1 protein networkhttps://string-db.org/network/9606.ENSP00000463982YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites [...]
PITPNC1 protein networkhttps://string-db.org/network/9606.ENSP00000464006Cytoplasmic phosphatidylinositol transfer protein 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding [...]
IKBKE protein networkhttps://string-db.org/network/9606.ENSP00000464030Inhibitor of nuclear factor kappa-B kinase subunit epsilon; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of [...]
CDK11B protein networkhttps://string-db.org/network/9606.ENSP00000464036Cyclin-dependent kinase 11B; Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. Isoform 7 may act as [...]
DDX42 protein networkhttps://string-db.org/network/9606.ENSP00000464050ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence [...]
RNF213 protein networkhttps://string-db.org/network/9606.ENSP00000464087E3 ubiquitin-protein ligase RNF213; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitina [...]
ADAP2 protein networkhttps://string-db.org/network/9606.ENSP00000464121Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inosi [...]
GDF10 protein networkhttps://string-db.org/network/9606.ENSP00000464145Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhi [...]
GREB1L protein networkhttps://string-db.org/network/9606.ENSP00000464162GREB1-like protein; Plays a major role in early metanephros and genital development.
J3QRE1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000464167Uncharacterized protein.
CYB561 protein networkhttps://string-db.org/network/9606.ENSP00000464215Cytochrome b561; Secretory vesicle-specific electron transport protein.
ZNF286A protein networkhttps://string-db.org/network/9606.ENSP00000464218Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SLC25A35 protein networkhttps://string-db.org/network/9606.ENSP00000464231Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family.
VHLL protein networkhttps://string-db.org/network/9606.ENSP00000464258Von Hippel-Lindau-like protein; Functions as a dominant-negative VHL to serve as a protector of HIFalpha.
C17orf75 protein networkhttps://string-db.org/network/9606.ENSP00000464275Protein Njmu-R1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. May have a role in spermatogenesis.
MYH3 protein networkhttps://string-db.org/network/9606.ENSP00000464317Myosin-3; Muscle contraction.
C18orf63 protein networkhttps://string-db.org/network/9606.ENSP00000464330Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63.
RPL36 protein networkhttps://string-db.org/network/9606.ENSP0000046434260S ribosomal protein L36; Component of the large ribosomal subunit.
CENPX protein networkhttps://string-db.org/network/9606.ENSP00000464357Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 comple [...]
MYL12A protein networkhttps://string-db.org/network/9606.ENSP00000464359Myosin regulatory light chain 12A; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Impl [...]
L7N2F9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000464383V-SNARE coiled-coil homology domain-containing protein.
TSHZ1 protein networkhttps://string-db.org/network/9606.ENSP00000464391Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger prote [...]
IFT20 protein networkhttps://string-db.org/network/9606.ENSP00000464443Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins [...]
HELZ protein networkhttps://string-db.org/network/9606.ENSP00000464512Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo; Belongs to the DNA2/NAM7 helicase [...]
TIMM23 protein networkhttps://string-db.org/network/9606.ENSP00000464522Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across th [...]
LRRC37A3 protein networkhttps://string-db.org/network/9606.ENSP00000464535Leucine-rich repeat-containing protein 37A3; Leucine rich repeat containing 37 member A3.
OTOP3 protein networkhttps://string-db.org/network/9606.ENSP00000464577Proton channel OTOP3; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellu [...]
PPIAL4H protein networkhttps://string-db.org/network/9606.ENSP00000464619Peptidyl-prolyl cis-trans isomerase A-like 4H; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to th [...]
AMZ2 protein networkhttps://string-db.org/network/9606.ENSP00000464635Archaemetzincin-2; Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2. Belongs to the peptidase M54 family.
TPGS2 protein networkhttps://string-db.org/network/9606.ENSP00000464780Tubulin polyglutamylase complex subunit 2.
ZNF285 protein networkhttps://string-db.org/network/9606.ENSP00000464788Zinc finger protein 285; May be involved in transcriptional regulation.
RPL27 protein networkhttps://string-db.org/network/9606.ENSP0000046481360S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs.
COASY protein networkhttps://string-db.org/network/9606.ENSP00000464814Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantet [...]
CAPNS1 protein networkhttps://string-db.org/network/9606.ENSP00000464849Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal [...]
ZNF519 protein networkhttps://string-db.org/network/9606.ENSP00000464872Zinc finger protein 519; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
UNK protein networkhttps://string-db.org/network/9606.ENSP00000464893RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during em [...]
MFSD11 protein networkhttps://string-db.org/network/9606.ENSP00000464932UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family.
PLEKHJ1 protein networkhttps://string-db.org/network/9606.ENSP00000464955Pleckstrin homology domain containing J1.
ZNF850 protein networkhttps://string-db.org/network/9606.ENSP00000464976Zinc finger protein 850; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MAP4K1 protein networkhttps://string-db.org/network/9606.ENSP00000465039Mitogen-activated protein kinase kinase kinase kinase 1; Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-termi [...]
SPC24 protein networkhttps://string-db.org/network/9606.ENSP00000465075Kinetochore protein Spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for ki [...]
CD3EAP protein networkhttps://string-db.org/network/9606.ENSP00000465099DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...]
MXRA7 protein networkhttps://string-db.org/network/9606.ENSP00000465103Matrix-remodeling-associated protein 7; Matrix remodeling associated 7.
ZNF226 protein networkhttps://string-db.org/network/9606.ENSP00000465121Zinc finger protein 226; May be involved in transcriptional regulation.
MISP3 protein networkhttps://string-db.org/network/9606.ENSP00000465157Uncharacterized protein MISP3; MISP family member 3; Belongs to the MISP family.
CNTD1 protein networkhttps://string-db.org/network/9606.ENSP00000465204Cyclin N-terminal domain containing 1.
K7EJK4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000465212KRAB domain-containing protein.
POP4 protein networkhttps://string-db.org/network/9606.ENSP00000465213Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
GCOM1 protein networkhttps://string-db.org/network/9606.ENSP00000465231GRINL1A combined protein 15; GRINL1A complex locus 1.
CBARP protein networkhttps://string-db.org/network/9606.ENSP00000465260Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subuni [...]
TMC6 protein networkhttps://string-db.org/network/9606.ENSP00000465261Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family.
KCNJ16 protein networkhttps://string-db.org/network/9606.ENSP00000465295Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...]
APOC1 protein networkhttps://string-db.org/network/9606.ENSP00000465356Truncated apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Assoc [...]
TJP3 protein networkhttps://string-db.org/network/9606.ENSP00000465419Tight junction protein ZO-3; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, an [...]
C19orf53 protein networkhttps://string-db.org/network/9606.ENSP00000465432Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy.
TNFRSF11A protein networkhttps://string-db.org/network/9606.ENSP00000465500Tumor necrosis factor receptor superfamily member 11A; Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis. Involved in the regulation of interactions between [...]
C18orf21 protein networkhttps://string-db.org/network/9606.ENSP00000465517UPF0711 protein C18orf21; Chromosome 18 open reading frame 21.
ZNF529 protein networkhttps://string-db.org/network/9606.ENSP00000465578Zinc finger protein 529; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ACSBG2 protein networkhttps://string-db.org/network/9606.ENSP00000465589Long-chain-fatty-acid--CoA ligase ACSBG2; Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular [...]
IER2 protein networkhttps://string-db.org/network/9606.ENSP00000465617Immediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway a [...]
EVPL protein networkhttps://string-db.org/network/9606.ENSP00000465630Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
TMEM100 protein networkhttps://string-db.org/network/9606.ENSP00000465638Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation [...]
PIAS2 protein networkhttps://string-db.org/network/9606.ENSP00000465676E3 SUMO-protein ligase PIAS2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...]
AP1M2 protein networkhttps://string-db.org/network/9606.ENSP00000465685AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate t [...]
C10orf82 protein networkhttps://string-db.org/network/9606.ENSP00000465712Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82.
SLC16A2 protein networkhttps://string-db.org/network/9606.ENSP00000465734Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidot [...]
CCDC106 protein networkhttps://string-db.org/network/9606.ENSP00000465757Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity.
POLRMT protein networkhttps://string-db.org/network/9606.ENSP00000465759DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Compo [...]
ELOF1 protein networkhttps://string-db.org/network/9606.ENSP00000465765Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.
CCDC130 protein networkhttps://string-db.org/network/9606.ENSP00000465776Coiled-coil domain containing 130; Belongs to the CWC16 family.
MPPE1 protein networkhttps://string-db.org/network/9606.ENSP00000465894Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation [...]
GSG1L2 protein networkhttps://string-db.org/network/9606.ENSP00000465978Germ cell-specific gene 1-like protein 2; GSG1 like 2.
KIF18B protein networkhttps://string-db.org/network/9606.ENSP00000465992Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 alo [...]
PPY protein networkhttps://string-db.org/network/9606.ENSP00000466009Pancreatic icosapeptide; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
RPS15 protein networkhttps://string-db.org/network/9606.ENSP00000466010Ribosomal protein S15.
CEBPG protein networkhttps://string-db.org/network/9606.ENSP00000466022CCAAT/enhancer-binding protein gamma; Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) [...]
CIRBP protein networkhttps://string-db.org/network/9606.ENSP00000466025Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival [...]
ZNF581 protein networkhttps://string-db.org/network/9606.ENSP00000466047Zinc finger protein 581; May be involved in transcriptional regulation.
ZNF404 protein networkhttps://string-db.org/network/9606.ENSP00000466051Zinc finger protein 404; May be involved in transcriptional regulation.
LYPD8 protein networkhttps://string-db.org/network/9606.ENSP00000466070Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the larg [...]
ZSCAN5B protein networkhttps://string-db.org/network/9606.ENSP00000466072Zinc finger and SCAN domain-containing protein 5B; May be involved in transcriptional regulation.
ELANE protein networkhttps://string-db.org/network/9606.ENSP00000466090Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not [...]
RNMT protein networkhttps://string-db.org/network/9606.ENSP00000466111mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of [...]
FAAP24 protein networkhttps://string-db.org/network/9606.ENSP00000466121Fanconi anemia core complex-associated protein 24; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induc [...]
PRKCSH protein networkhttps://string-db.org/network/9606.ENSP00000466134Glucosidase 2 subunit beta; Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precurs [...]
ENSP00000466140 protein networkhttps://string-db.org/network/9606.ENSP00000466140Novel protein.
ATF7-NPFF protein networkhttps://string-db.org/network/9606.ENSP00000466174Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in [...]
PDCD5 protein networkhttps://string-db.org/network/9606.ENSP00000466214Programmed cell death protein 5; May function in the process of apoptosis.
ACLY protein networkhttps://string-db.org/network/9606.ENSP00000466259ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. In the N-termina [...]
NLRP11 protein networkhttps://string-db.org/network/9606.ENSP00000466285NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; Belongs to the NLRP family.
STX10 protein networkhttps://string-db.org/network/9606.ENSP00000466298Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family.
PIP5K1C protein networkhttps://string-db.org/network/9606.ENSP00000466363Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) [...]
GET3 protein networkhttps://string-db.org/network/9606.ENSP00000466379ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA pro [...]
RAD51D protein networkhttps://string-db.org/network/9606.ENSP00000466399DNA repair protein RAD51 homolog 4; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. B [...]
TSSK6 protein networkhttps://string-db.org/network/9606.ENSP00000466477Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).
ZNF396 protein networkhttps://string-db.org/network/9606.ENSP00000466500Zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.
K7EMI3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000466514Uncharacterized protein.
TLE2 protein networkhttps://string-db.org/network/9606.ENSP00000466542Transducin-like enhancer protein 2; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members [...]
CEACAM16 protein networkhttps://string-db.org/network/9606.ENSP00000466561Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
K7EMT4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000466639Uncharacterized protein.
SLC44A2 protein networkhttps://string-db.org/network/9606.ENSP00000466664Choline transporter-like protein 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Belongs to the CTL (choline transporter-like) family.
RND2 protein networkhttps://string-db.org/network/9606.ENSP00000466680Rho-related GTP-binding protein RhoN; May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
CCDC68 protein networkhttps://string-db.org/network/9606.ENSP00000466690Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate wi [...]
LSM12 protein networkhttps://string-db.org/network/9606.ENSP00000466718LSM12 homolog.
APOC2 protein networkhttps://string-db.org/network/9606.ENSP00000466775Proapolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in [...]
COX6B1 protein networkhttps://string-db.org/network/9606.ENSP00000466818Cytochrome c oxidase subunit 6B1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chai [...]
RAD51D-2 protein networkhttps://string-db.org/network/9606.ENSP00000466834HCG2039718, isoform CRA_g.
GCDH protein networkhttps://string-db.org/network/9606.ENSP00000466845Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-trypto [...]
FUT5 protein networkhttps://string-db.org/network/9606.ENSP00000466880Alpha-(1,3)-fucosyltransferase 5; May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.
PLPPR2 protein networkhttps://string-db.org/network/9606.ENSP00000466898Phospholipid phosphatase-related protein type 2; Phospholipid phosphatase related 2.
ZNF524 protein networkhttps://string-db.org/network/9606.ENSP00000466907Zinc finger protein 524; May be involved in transcriptional regulation.
FHOD3 protein networkhttps://string-db.org/network/9606.ENSP00000466937FH1/FH2 domain-containing protein 3; Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament poly [...]
WTIP protein networkhttps://string-db.org/network/9606.ENSP00000466953Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell [...]
TRMT1 protein networkhttps://string-db.org/network/9606.ENSP00000466967tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
RAD23A protein networkhttps://string-db.org/network/9606.ENSP00000467024UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent ma [...]
INO80C-2 protein networkhttps://string-db.org/network/9606.ENSP00000467041Uncharacterized protein.
RINL protein networkhttps://string-db.org/network/9606.ENSP00000467107Ras and Rab interactor-like protein; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosi [...]
NLRP7 protein networkhttps://string-db.org/network/9606.ENSP00000467123NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion. Belongs to the NLRP family.
TTN protein networkhttps://string-db.org/network/9606.ENSP00000467141Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forc [...]
TNNT1 protein networkhttps://string-db.org/network/9606.ENSP00000467176Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin A [...]
GJC1 protein networkhttps://string-db.org/network/9606.ENSP00000467201Gap junction gamma-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
ZNF570 protein networkhttps://string-db.org/network/9606.ENSP00000467218Zinc finger protein 570; May be involved in transcriptional regulation.
UQCR11 protein networkhttps://string-db.org/network/9606.ENSP00000467262Cytochrome b-c1 complex subunit 10; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which d [...]
COX6B2 protein networkhttps://string-db.org/network/9606.ENSP00000467266Cytochrome c oxidase subunit 6B2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chai [...]
ABCA8 protein networkhttps://string-db.org/network/9606.ENSP00000467271ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter.
ZNF69-2 protein networkhttps://string-db.org/network/9606.ENSP00000467286Zinc finger protein 69; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SEMA6B protein networkhttps://string-db.org/network/9606.ENSP00000467290Semaphorin-6B; May play a role in both peripheral and central nervous system development.
OR4F17 protein networkhttps://string-db.org/network/9606.ENSP00000467301Olfactory receptor 4F17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SAFB protein networkhttps://string-db.org/network/9606.ENSP00000467423Scaffold attachment factor B1; Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR [...]
GIPR protein networkhttps://string-db.org/network/9606.ENSP00000467494Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled rece [...]
PTPRS protein networkhttps://string-db.org/network/9606.ENSP00000467537Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chon [...]
GPATCH8 protein networkhttps://string-db.org/network/9606.ENSP00000467556G-patch domain containing 8.
WBP2 protein networkhttps://string-db.org/network/9606.ENSP00000467579WW domain-binding protein 2; Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive p [...]
SYNGR2 protein networkhttps://string-db.org/network/9606.ENSP00000467600Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the f [...]
PRCD protein networkhttps://string-db.org/network/9606.ENSP00000467661Photoreceptor disk component PRCD; Involved in vision; Belongs to the PRCD family.
ZNF699 protein networkhttps://string-db.org/network/9606.ENSP00000467723Zinc finger protein 699; May be involved in transcriptional regulation.
ANKRD62 protein networkhttps://string-db.org/network/9606.ENSP00000467740Ankyrin repeat domain 62.
LINGO3 protein networkhttps://string-db.org/network/9606.ENSP00000467753Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3.
BOD1L2 protein networkhttps://string-db.org/network/9606.ENSP00000467843Biorientation of chromosomes in cell division protein 1-like 2; May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles; [...]
ZNF461 protein networkhttps://string-db.org/network/9606.ENSP00000467931Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
K7EQS6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000467958Uncharacterized protein.
KANK2 protein networkhttps://string-db.org/network/9606.ENSP00000468002KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involv [...]
LUZP6 protein networkhttps://string-db.org/network/9606.ENSP00000468007Leucine zipper protein 6.
TMEM101 protein networkhttps://string-db.org/network/9606.ENSP00000468025Transmembrane protein 101; May activate NF-kappa-B signaling pathways.
SARM1 protein networkhttps://string-db.org/network/9606.ENSP00000468032NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent [...]
K7EQZ3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468040BPTI/Kunitz inhibitor domain-containing protein.
ZNF101 protein networkhttps://string-db.org/network/9606.ENSP00000468049Zinc finger protein 101; May be involved in transcriptional regulation.
MC5R protein networkhttps://string-db.org/network/9606.ENSP00000468086Melanocortin receptor 5; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible m [...]
ZNF559 protein networkhttps://string-db.org/network/9606.ENSP00000468153Zinc finger protein 559; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CCDC159 protein networkhttps://string-db.org/network/9606.ENSP00000468232Coiled-coil domain containing 159.
APOC4 protein networkhttps://string-db.org/network/9606.ENSP00000468236Apolipoprotein C-IV; May participate in lipoprotein metabolism.
CFD protein networkhttps://string-db.org/network/9606.ENSP00000468253Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its funct [...]
K7ERI5_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468271KRAB domain-containing protein.
K7ERJ3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468280Uncharacterized protein.
MBTD1 protein networkhttps://string-db.org/network/9606.ENSP00000468304MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering [...]
FAM20A protein networkhttps://string-db.org/network/9606.ENSP00000468308Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM2 [...]
EML2 protein networkhttps://string-db.org/network/9606.ENSP00000468312Echinoderm microtubule-associated protein-like 2; Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
MAP2K6 protein networkhttps://string-db.org/network/9606.ENSP00000468348Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, c [...]
ANKRD29 protein networkhttps://string-db.org/network/9606.ENSP00000468354Ankyrin repeat domain 29.
K7ERQ8_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468367PCAF_N domain-containing protein.
PLK5 protein networkhttps://string-db.org/network/9606.ENSP00000468376Inactive serine/threonine-protein kinase PLK5; Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation. Belongs to the protein kinase sup [...]
PSENEN protein networkhttps://string-db.org/network/9606.ENSP00000468411Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch rece [...]
NMT1 protein networkhttps://string-db.org/network/9606.ENSP00000468424Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Belongs to the NMT family.
TK1 protein networkhttps://string-db.org/network/9606.ENSP00000468425Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family.
BCAS3 protein networkhttps://string-db.org/network/9606.ENSP00000468592Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation an [...]
SEC11C protein networkhttps://string-db.org/network/9606.ENSP00000468633Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen [...]
ZNF121 protein networkhttps://string-db.org/network/9606.ENSP00000468643Zinc finger protein 121; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PLEKHH3 protein networkhttps://string-db.org/network/9606.ENSP00000468678Pleckstrin homology, MyTH4 and FERM domain containing H3.
K7ESF4_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468690Uncharacterized protein.
ZNF253 protein networkhttps://string-db.org/network/9606.ENSP00000468720Zinc finger protein 253; May function as a transcription factor. Seem to have a transcriptional repression activity; Belongs to the krueppel C2H2-type zinc-finger protein family.
MICOS13 protein networkhttps://string-db.org/network/9606.ENSP00000468723MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...]
ZBTB7C protein networkhttps://string-db.org/network/9606.ENSP00000468782Zinc finger and BTB domain-containing protein 7C; May be a tumor suppressor gene.
MBD1 protein networkhttps://string-db.org/network/9606.ENSP00000468785Methyl-CpG-binding domain protein 1; Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is aboli [...]
M0QX08_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000468837Protein kinase domain-containing protein.
FPR2 protein networkhttps://string-db.org/network/9606.ENSP00000468897N-formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrop [...]
STAP2 protein networkhttps://string-db.org/network/9606.ENSP00000468927Signal-transducing adaptor protein 2; Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
JOSD2 protein networkhttps://string-db.org/network/9606.ENSP00000468956Josephin-2; Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.
WDR83OS protein networkhttps://string-db.org/network/9606.ENSP00000468969Protein Asterix; WD repeat domain 83 opposite strand.
SLC25A53 protein networkhttps://string-db.org/network/9606.ENSP00000468980Solute carrier family 25 member 53.
MTRNR2L12 protein networkhttps://string-db.org/network/9606.ENSP00000468991MT-RNR2 like 12.
SSX4 protein networkhttps://string-db.org/network/9606.ENSP00000469011Protein SSX4; Could act as a modulator of transcription.
COPE protein networkhttps://string-db.org/network/9606.ENSP00000469035Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosy [...]
TNFSF14 protein networkhttps://string-db.org/network/9606.ENSP00000469049Tumor necrosis factor ligand superfamily member 14, membrane form; Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14 [...]
NPAS1 protein networkhttps://string-db.org/network/9606.ENSP00000469142Neuronal PAS domain-containing protein 1; May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulat [...]
SPHK2 protein networkhttps://string-db.org/network/9606.ENSP00000469158Sphingosine kinase 2; Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dih [...]
EMP3 protein networkhttps://string-db.org/network/9606.ENSP00000469194Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions.
HSFX2 protein networkhttps://string-db.org/network/9606.ENSP00000469223Heat shock transcription factor family, X-linked 2.
CHMP2A protein networkhttps://string-db.org/network/9606.ENSP00000469240Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
SPTBN4 protein networkhttps://string-db.org/network/9606.ENSP00000469242Spectrin beta chain, non-erythrocytic 4.
FAM156B protein networkhttps://string-db.org/network/9606.ENSP00000469248Protein FAM156A/FAM156B; Family with sequence similarity 156 member B.
KLK15 protein networkhttps://string-db.org/network/9606.ENSP00000469315Kallikrein-15; Protease whose physiological substrate is not yet known; Belongs to the peptidase S1 family. Kallikrein subfamily.
GABRQ protein networkhttps://string-db.org/network/9606.ENSP00000469332Gamma-aminobutyric acid receptor subunit theta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...]
LRRC63 protein networkhttps://string-db.org/network/9606.ENSP00000469337Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63.
ZNF677 protein networkhttps://string-db.org/network/9606.ENSP00000469391Zinc finger protein 677; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SSX4B protein networkhttps://string-db.org/network/9606.ENSP00000469394SSX family member 4B.
PAK4 protein networkhttps://string-db.org/network/9606.ENSP00000469413Serine/threonine-protein kinase PAK 4; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, pr [...]
KLK9 protein networkhttps://string-db.org/network/9606.ENSP00000469417Kallikrein-9; Kallikrein related peptidase 9.
CTAG1A protein networkhttps://string-db.org/network/9606.ENSP00000469441Cancer/testis antigen 1A.
PNMA3 protein networkhttps://string-db.org/network/9606.ENSP00000469445Paraneoplastic antigen Ma3; PNMA family member 3; Belongs to the PNMA family.
NTF4 protein networkhttps://string-db.org/network/9606.ENSP00000469455Neurotrophin-4; Target-derived survival factor for peripheral sensory sympathetic neurons.
LSM4 protein networkhttps://string-db.org/network/9606.ENSP00000469468U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatal [...]
CCDC177 protein networkhttps://string-db.org/network/9606.ENSP00000469474Coiled-coil domain containing 177.
WIZ protein networkhttps://string-db.org/network/9606.ENSP00000469534Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity).
ZNF729 protein networkhttps://string-db.org/network/9606.ENSP00000469582Zinc finger protein 729; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF628 protein networkhttps://string-db.org/network/9606.ENSP00000469591Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity).
FLT3LG protein networkhttps://string-db.org/network/9606.ENSP00000469613Fms-related tyrosine kinase 3 ligand; Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleuk [...]
EGLN2 protein networkhttps://string-db.org/network/9606.ENSP00000469686Egl nine homolog 2; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...]
PDE4C protein networkhttps://string-db.org/network/9606.ENSP00000469696Phosphodiesterase 4C.
LRIT3 protein networkhttps://string-db.org/network/9606.ENSP00000469759Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3; Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and [...]
M0QYG6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000469811Uncharacterized protein.
MPV17L2 protein networkhttps://string-db.org/network/9606.ENSP00000469836Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis ; Belongs to the peroxisomal membrane prote [...]
DYRK1B protein networkhttps://string-db.org/network/9606.ENSP00000469863Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity [...]
SCGB2B2 protein networkhttps://string-db.org/network/9606.ENSP00000469876Secretoglobin family 2B member 2.
VRK3 protein networkhttps://string-db.org/network/9606.ENSP00000469880Inactive serine/threonine-protein kinase VRK3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in t [...]
TRAPPC2B protein networkhttps://string-db.org/network/9606.ENSP00000469888Trafficking protein particle complex 2B.
ZNF626 protein networkhttps://string-db.org/network/9606.ENSP00000469958Zinc finger protein 626; May be involved in transcriptional regulation.
OPN1MW3 protein networkhttps://string-db.org/network/9606.ENSP00000469970Opsin 1, medium wave sensitive 3.
TAZ protein networkhttps://string-db.org/network/9606.ENSP00000469981Tafazzin; Some isoforms may be involved in cardiolipin (CL) metabolism. Belongs to the taffazin family.
ZNF114 protein networkhttps://string-db.org/network/9606.ENSP00000469998Zinc finger protein 114; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
M0QYT0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000470059RRM domain-containing protein.
M0QYU9_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000470086Uncharacterized protein.
M0QYV0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000470087Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
ZSCAN18 protein networkhttps://string-db.org/network/9606.ENSP00000470123Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation.
MIA protein networkhttps://string-db.org/network/9606.ENSP00000470129Melanoma-derived growth regulatory protein; Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas; Belongs to the MIA/OTOR family.
UPF1 protein networkhttps://string-db.org/network/9606.ENSP00000470142Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translatio [...]
DTNA protein networkhttps://string-db.org/network/9606.ENSP00000470152Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
AP2S1 protein networkhttps://string-db.org/network/9606.ENSP00000470176AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathway [...]
CT45A1 protein networkhttps://string-db.org/network/9606.ENSP00000470185Cancer/testis antigen family 45 member A1.
ZNF257 protein networkhttps://string-db.org/network/9606.ENSP00000470209Zinc finger protein 257; May be involved in transcriptional regulation.
ZNF836 protein networkhttps://string-db.org/network/9606.ENSP00000470239Zinc finger protein 836; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RAB4B protein networkhttps://string-db.org/network/9606.ENSP00000470246Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.
PRICKLE3 protein networkhttps://string-db.org/network/9606.ENSP00000470248Prickle planar cell polarity protein 3; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gas [...]
SUPT5H protein networkhttps://string-db.org/network/9606.ENSP00000470252Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. D [...]
SIGLEC5-2 protein networkhttps://string-db.org/network/9606.ENSP00000470259Sialic acid-binding Ig-like lectin 5; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sial [...]
TRAPPC5 protein networkhttps://string-db.org/network/9606.ENSP00000470262Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily.
ZNF329 protein networkhttps://string-db.org/network/9606.ENSP00000470323Zinc finger protein 329; May be involved in transcriptional regulation.
ZNF468 protein networkhttps://string-db.org/network/9606.ENSP00000470381Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
M0QZ92_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000470383SEC7 domain-containing protein.
RNF225 protein networkhttps://string-db.org/network/9606.ENSP00000470441Ring finger protein 225.
LOC400499 protein networkhttps://string-db.org/network/9606.ENSP00000470478Putative uncharacterized protein LOC400499.
KLK7 protein networkhttps://string-db.org/network/9606.ENSP00000470538Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino ac [...]
PET100 protein networkhttps://string-db.org/network/9606.ENSP00000470539Protein PET100 homolog, mitochondrial; PET100 cytochrome c oxidase chaperone; Belongs to the PET100 family.
KLK13 protein networkhttps://string-db.org/network/9606.ENSP00000470555Kallikrein-13; Kallikrein related peptidase 13.
EMG1 protein networkhttps://string-db.org/network/9606.ENSP00000470560Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. I [...]
SPANXN2 protein networkhttps://string-db.org/network/9606.ENSP00000470584Sperm protein associated with the nucleus on the X chromosome N2; SPANX family member N2.
ENSP00000470615 protein networkhttps://string-db.org/network/9606.ENSP00000470615Novel protein.
SLC35E1 protein networkhttps://string-db.org/network/9606.ENSP00000470652Solute carrier family 35 member E1; Putative transporter.
ZNF841 protein networkhttps://string-db.org/network/9606.ENSP00000470746Zinc finger protein 841; May be involved in transcriptional regulation.
IL12RB1 protein networkhttps://string-db.org/network/9606.ENSP00000470788Interleukin-12 receptor subunit beta-1; Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a [...]
SLC6A14 protein networkhttps://string-db.org/network/9606.ENSP00000470801Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/ [...]
CGB7 protein networkhttps://string-db.org/network/9606.ENSP00000470813Choriogonadotropin subunit beta 7; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalen [...]
TMEM59L protein networkhttps://string-db.org/network/9606.ENSP00000470879Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further [...]
M0R036_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000470969KRAB domain-containing protein.
RPS19 protein networkhttps://string-db.org/network/9606.ENSP0000047097240S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family.
ZNF616 protein networkhttps://string-db.org/network/9606.ENSP00000471000Zinc finger protein 616; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MAGEA9B protein networkhttps://string-db.org/network/9606.ENSP00000471017MAGE family member A9B.
ZNF615 protein networkhttps://string-db.org/network/9606.ENSP00000471041Zinc finger protein 615; May be involved in transcriptional regulation.
M0R082_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000471077Uncharacterized protein.
SMIM17 protein networkhttps://string-db.org/network/9606.ENSP00000471126Small integral membrane protein 17.
NUP62 protein networkhttps://string-db.org/network/9606.ENSP00000471191Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein i [...]
DMRTC1 protein networkhttps://string-db.org/network/9606.ENSP00000471224DMRT like family C1.
ZFP36 protein networkhttps://string-db.org/network/9606.ENSP00000471239mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal [...]
ANKRD24 protein networkhttps://string-db.org/network/9606.ENSP00000471252Ankyrin repeat domain 24.
ZNF558 protein networkhttps://string-db.org/network/9606.ENSP00000471277Zinc finger protein 558; May be involved in transcriptional regulation.
MAGIX protein networkhttps://string-db.org/network/9606.ENSP00000471299PDZ domain-containing protein MAGIX; MAGI family member, X-linked.
ANKDD1B protein networkhttps://string-db.org/network/9606.ENSP00000471417Ankyrin repeat and death domain containing 1B.
CT45A3 protein networkhttps://string-db.org/network/9606.ENSP00000471418Cancer/testis antigen family 45 member A3; Belongs to the CT45 family.
CCDC61 protein networkhttps://string-db.org/network/9606.ENSP00000471454Coiled-coil domain containing 61.
CCDC124 protein networkhttps://string-db.org/network/9606.ENSP00000471455Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages. Belongs to the CCDC124 family.
MYO9B protein networkhttps://string-db.org/network/9606.ENSP00000471457Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absenc [...]
FGF21 protein networkhttps://string-db.org/network/9606.ENSP00000471477Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity re [...]
FPR1 protein networkhttps://string-db.org/network/9606.ENSP00000471493fMet-Leu-Phe receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular c [...]
DEDD2 protein networkhttps://string-db.org/network/9606.ENSP00000471512DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of in [...]
ZNF726 protein networkhttps://string-db.org/network/9606.ENSP00000471516Zinc finger protein 726; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
MARCHF2 protein networkhttps://string-db.org/network/9606.ENSP00000471536E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesic [...]
MBD3L1 protein networkhttps://string-db.org/network/9606.ENSP00000471575Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor.
ZNF728 protein networkhttps://string-db.org/network/9606.ENSP00000471593Zinc finger protein 728.
TEX13A protein networkhttps://string-db.org/network/9606.ENSP00000471604Testis-expressed protein 13A; Testis expressed 13A; Belongs to the TEX13 family.
SCGB1C2 protein networkhttps://string-db.org/network/9606.ENSP00000471646Secretoglobin family 1C member 2.
SLC38A5 protein networkhttps://string-db.org/network/9606.ENSP00000471683Sodium-coupled neutral amino acid transporter 5; Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotr [...]
FKBP8 protein networkhttps://string-db.org/network/9606.ENSP00000471700Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitoc [...]
MPND protein networkhttps://string-db.org/network/9606.ENSP00000471735MPN domain-containing protein; Probable protease (By similarity). Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation. Bel [...]
ZNF480 protein networkhttps://string-db.org/network/9606.ENSP00000471754Zinc finger protein 480; Involved in transcriptional regulation as an activator.
ADAMTS10 protein networkhttps://string-db.org/network/9606.ENSP00000471851A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independen [...]
HAMP protein networkhttps://string-db.org/network/9606.ENSP00000471894Hepcidin-20; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroporti [...]
IRF3 protein networkhttps://string-db.org/network/9606.ENSP00000471896Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA [...]
SPIB protein networkhttps://string-db.org/network/9606.ENSP00000471921Transcription factor Spi-B; Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes [...]
TMEM185A protein networkhttps://string-db.org/network/9606.ENSP00000471932Transmembrane protein 185A; Belongs to the TMEM185 family.
TEAD2 protein networkhttps://string-db.org/network/9606.ENSP00000472109Transcriptional enhancer factor TEF-4; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...]
MAGED4 protein networkhttps://string-db.org/network/9606.ENSP00000472118MAGE family member D4.
NOTCH2NLB protein networkhttps://string-db.org/network/9606.ENSP00000472124Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling [...]
M0R1W7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000472152Uncharacterized protein.
M0R1X1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000472160KRAB domain-containing protein.
GMFG protein networkhttps://string-db.org/network/9606.ENSP00000472249Glia maturation factor gamma.
M0R233_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000472277KRAB domain-containing protein.
ZNF358 protein networkhttps://string-db.org/network/9606.ENSP00000472305Zinc finger protein 358; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
TEX101 protein networkhttps://string-db.org/network/9606.ENSP00000472308Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in sig [...]
OPN1MW protein networkhttps://string-db.org/network/9606.ENSP00000472316Opsin 1, medium wave sensitive.
ARL14EPL protein networkhttps://string-db.org/network/9606.ENSP00000472409ARL14 effector protein-like; ADP ribosylation factor like GTPase 14 effector protein like.
FAM71E1 protein networkhttps://string-db.org/network/9606.ENSP00000472421Protein FAM71E1; Family with sequence similarity 71 member E1.
POLD1 protein networkhttps://string-db.org/network/9606.ENSP00000472445DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in [...]
SARS2-2 protein networkhttps://string-db.org/network/9606.ENSP00000472465Uncharacterized protein.
CXCL17 protein networkhttps://string-db.org/network/9606.ENSP00000472467C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an [...]
RPS28 protein networkhttps://string-db.org/network/9606.ENSP00000472469Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family.
IL4I1 protein networkhttps://string-db.org/network/9606.ENSP00000472474L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity).
NXF2B protein networkhttps://string-db.org/network/9606.ENSP00000472530Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family.
PLA2G4C protein networkhttps://string-db.org/network/9606.ENSP00000472546Cytosolic phospholipase A2 gamma; Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid.
ZNF83 protein networkhttps://string-db.org/network/9606.ENSP00000472619Zinc finger protein 83; May be involved in transcriptional regulation.
C5AR2 protein networkhttps://string-db.org/network/9606.ENSP00000472620C5a anaphylatoxin chemotactic receptor 2; Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C [...]
ASCL5 protein networkhttps://string-db.org/network/9606.ENSP00000472681Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5.
M0R2N6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000472698XRCC1_N domain-containing protein.
TMSB15B-2 protein networkhttps://string-db.org/network/9606.ENSP00000472749Thymosin beta 15B.
ZNF446 protein networkhttps://string-db.org/network/9606.ENSP00000472802Zinc finger protein 446; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF473 protein networkhttps://string-db.org/network/9606.ENSP00000472808Zinc finger protein 473; Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but h [...]
KXD1 protein networkhttps://string-db.org/network/9606.ENSP00000472836KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BOR [...]
SARS2 protein networkhttps://string-db.org/network/9606.ENSP00000472847Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), w [...]
ZIK1 protein networkhttps://string-db.org/network/9606.ENSP00000472867Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor.
M0R2Z0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000472894KRAB domain-containing protein.
SUGP2 protein networkhttps://string-db.org/network/9606.ENSP00000472914SURP and G-patch domain-containing protein 2; May play a role in mRNA splicing.
ERVV-2 protein networkhttps://string-db.org/network/9606.ENSP00000472919Endogenous retrovirus group V member 2, envelope; Belongs to the gamma type-C retroviral envelope protein family.
VAV1 protein networkhttps://string-db.org/network/9606.ENSP00000472929Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
ZNF730 protein networkhttps://string-db.org/network/9606.ENSP00000472959Putative zinc finger protein 730; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ZNF99 protein networkhttps://string-db.org/network/9606.ENSP00000472969Zinc finger protein 99; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
RPS5 protein networkhttps://string-db.org/network/9606.ENSP0000047298540S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family.
SNRNP70 protein networkhttps://string-db.org/network/9606.ENSP00000472998U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome [...]
FCHO1 protein networkhttps://string-db.org/network/9606.ENSP00000473001F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formati [...]
PNMA8B protein networkhttps://string-db.org/network/9606.ENSP00000473036Paraneoplastic antigen-like protein 8B; PNMA family member 8B.
KLK11 protein networkhttps://string-db.org/network/9606.ENSP00000473047Kallikrein-11 inactive chain 1; Possible multifunctional protease. Efficiently cleaves 'bz- Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kall [...]
ZNF320 protein networkhttps://string-db.org/network/9606.ENSP00000473091Zinc finger protein 320; May be involved in transcriptional regulation.
MAGEA3 protein networkhttps://string-db.org/network/9606.ENSP00000473093Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and [...]
ERVV-1 protein networkhttps://string-db.org/network/9606.ENSP00000473153Endogenous retrovirus group V member 1, envelope; Belongs to the gamma type-C retroviral envelope protein family.
FFAR2 protein networkhttps://string-db.org/network/9606.ENSP00000473159Free fatty acid receptor 2; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulatio [...]
RUVBL2 protein networkhttps://string-db.org/network/9606.ENSP00000473172RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits [...]
SELENOW protein networkhttps://string-db.org/network/9606.ENSP00000473185Selenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity); B [...]
ZNF334 protein networkhttps://string-db.org/network/9606.ENSP00000473194Zinc finger protein 334; May be involved in transcriptional regulation.
M0R3G1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000473200Prp18 domain-containing protein.
GPR42 protein networkhttps://string-db.org/network/9606.ENSP00000473212G-protein coupled receptor 42; Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a ro [...]
M0R3H8_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000473233ETS domain-containing protein.
SIGLEC5 protein networkhttps://string-db.org/network/9606.ENSP00000473238Sialic acid binding Ig like lectin 5.
NELFCD protein networkhttps://string-db.org/network/9606.ENSP00000473290Negative elongation factor C/D; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via [...]
H6PD protein networkhttps://string-db.org/network/9606.ENSP00000473348GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosph [...]
FXYD4 protein networkhttps://string-db.org/network/9606.ENSP00000473361FXYD domain containing ion transport regulator 4.
MEI4 protein networkhttps://string-db.org/network/9606.ENSP00000473370Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and R [...]
OAZ1 protein networkhttps://string-db.org/network/9606.ENSP00000473381Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...]
FBLL1 protein networkhttps://string-db.org/network/9606.ENSP00000473383rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA pro [...]
COMMD3-BMI1 protein networkhttps://string-db.org/network/9606.ENSP00000473391COMMD3-BMI1 readthrough.
MFSD14C protein networkhttps://string-db.org/network/9606.ENSP00000473444Hippocampus abundant transcript-like protein 2; Major facilitator superfamily domain containing 14C.
DENND4C protein networkhttps://string-db.org/network/9606.ENSP00000473469DENN domain-containing protein 4C; Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound fo [...]
SDR42E2 protein networkhttps://string-db.org/network/9606.ENSP00000473474Short chain dehydrogenase/reductase family 42E, member 2; Belongs to the 3-beta-HSD family.
MAGEB5 protein networkhttps://string-db.org/network/9606.ENSP00000473493Melanoma-associated antigen B5; MAGE family member B5.
CSNK2A3 protein networkhttps://string-db.org/network/9606.ENSP00000473553Casein kinase II subunit alpha 3; Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic [...]
UBE2E3 protein networkhttps://string-db.org/network/9606.ENSP00000473623Ubiquitin-conjugating enzyme E2 E3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'- [...]
DNAJC3 protein networkhttps://string-db.org/network/9606.ENSP00000473631DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by pr [...]
SBNO1 protein networkhttps://string-db.org/network/9606.ENSP00000473665Strawberry notch homolog 1.
MTRNR2L6 protein networkhttps://string-db.org/network/9606.ENSP00000473686Humanin-like 6; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
EBLN1 protein networkhttps://string-db.org/network/9606.ENSP00000473842Endogenous Bornavirus-like nucleoprotein 1; May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).
MMP28 protein networkhttps://string-db.org/network/9606.ENSP00000473853Matrix metalloproteinase-28; Can degrade casein. Could play a role in tissues homeostasis and repair.
FXYD3 protein networkhttps://string-db.org/network/9606.ENSP00000473929FXYD domain-containing ion transport regulator 3; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into [...]
HEATR9 protein networkhttps://string-db.org/network/9606.ENSP00000473941Protein HEATR9; HEAT repeat containing 9.
MRPL37 protein networkhttps://string-db.org/network/9606.ENSP00000473980Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family.
ALDH3B1 protein networkhttps://string-db.org/network/9606.ENSP00000473990Aldehyde dehydrogenase family 3 member B1; Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyph [...]
TRIM77 protein networkhttps://string-db.org/network/9606.ENSP00000474003Tripartite motif containing 77; Belongs to the TRIM/RBCC family.
DYNC2LI1 protein networkhttps://string-db.org/network/9606.ENSP00000474032Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and function [...]
CCDC120 protein networkhttps://string-db.org/network/9606.ENSP00000474071Coiled-coil domain-containing protein 120; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC68, cooperate wi [...]
UPP2 protein networkhttps://string-db.org/network/9606.ENSP00000474090Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as [...]
TAF15 protein networkhttps://string-db.org/network/9606.ENSP00000474096TATA-binding protein-associated factor 2N; RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex to [...]
IGHV3-11 protein networkhttps://string-db.org/network/9606.ENSP00000474135Immunoglobulin heavy variable 3-11; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
LEKR1 protein networkhttps://string-db.org/network/9606.ENSP00000474182Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1.
CTAGE15 protein networkhttps://string-db.org/network/9606.ENSP00000474204CTAGE family member 15.
RASL10B protein networkhttps://string-db.org/network/9606.ENSP00000474230Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small G [...]
IZUMO3 protein networkhttps://string-db.org/network/9606.ENSP00000474246Izumo sperm-egg fusion protein 3; IZUMO family member 3.
SETD1B protein networkhttps://string-db.org/network/9606.ENSP00000474253Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if [...]
ADAM21 protein networkhttps://string-db.org/network/9606.ENSP00000474385Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing [...]
CTAGE6 protein networkhttps://string-db.org/network/9606.ENSP00000474388CTAGE family member 6.
CCL5 protein networkhttps://string-db.org/network/9606.ENSP00000474412C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several c [...]
NBPF1 protein networkhttps://string-db.org/network/9606.ENSP00000474456Neuroblastoma breakpoint family member 1; NBPF member 1; Belongs to the NBPF family.
LIX1L protein networkhttps://string-db.org/network/9606.ENSP00000474487LIX1-like protein; Limb and CNS expressed 1 like; Belongs to the LIX1 family.
GAS2L2 protein networkhttps://string-db.org/network/9606.ENSP00000474529GAS2-like protein 2; Involved in the cross-linking of microtubules and microfilaments. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, suc [...]
HSPE1-MOB4 protein networkhttps://string-db.org/network/9606.ENSP00000474534HSPE1-MOB4 readthrough; Belongs to the GroES chaperonin family.
HADH protein networkhttps://string-db.org/network/9606.ENSP00000474560Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-Co [...]
MTRNR2L13 protein networkhttps://string-db.org/network/9606.ENSP00000474570Humanin-like 13; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
SLC22A31 protein networkhttps://string-db.org/network/9606.ENSP00000474621Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2. [...]
ARMCX5 protein networkhttps://string-db.org/network/9606.ENSP00000474720Armadillo repeat containing X-linked 5.
FBXW7 protein networkhttps://string-db.org/network/9606.ENSP00000474725F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent prote [...]
RNF103-CHMP3 protein networkhttps://string-db.org/network/9606.ENSP00000474823RNF103-CHMP3 readthrough.
TRIM49D1 protein networkhttps://string-db.org/network/9606.ENSP00000474850Tripartite motif containing 49D1; Belongs to the TRIM/RBCC family.
MTRNR2L11 protein networkhttps://string-db.org/network/9606.ENSP00000474861Humanin-like 11; Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family.
TPBGL protein networkhttps://string-db.org/network/9606.ENSP00000474988Trophoblast glycoprotein like.
TLCD4-RWDD3 protein networkhttps://string-db.org/network/9606.ENSP00000475025TLCD4-RWDD3 readthrough.
UGT2A2 protein networkhttps://string-db.org/network/9606.ENSP00000475028UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...]
SMAGP protein networkhttps://string-db.org/network/9606.ENSP00000475068Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.
IGHV3OR16-9 protein networkhttps://string-db.org/network/9606.ENSP00000475107Immunoglobulin heavy variable 3/OR16-9.
C17orf50 protein networkhttps://string-db.org/network/9606.ENSP00000475146Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50.
RER1 protein networkhttps://string-db.org/network/9606.ENSP00000475168Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family.
ANKRD34A protein networkhttps://string-db.org/network/9606.ENSP00000475189Ankyrin repeat domain 34A.
KPRP protein networkhttps://string-db.org/network/9606.ENSP00000475216Keratinocyte proline rich protein.
ASDURF protein networkhttps://string-db.org/network/9606.ENSP00000475224ASNSD1 upstream reading frame.
A3GALT2 protein networkhttps://string-db.org/network/9606.ENSP00000475261Alpha-1,3-galactosyltransferase 2; Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of [...]
LCE1C protein networkhttps://string-db.org/network/9606.ENSP00000475270Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.
APLNR protein networkhttps://string-db.org/network/9606.ENSP00000475344Apelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early d [...]
U3KPZ7_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000475384Uncharacterized protein.
CHURC1 protein networkhttps://string-db.org/network/9606.ENSP00000475473Protein Churchill; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself; B [...]
MPHOSPH9 protein networkhttps://string-db.org/network/9606.ENSP00000475489M-phase phosphoprotein 9.
CWC15 protein networkhttps://string-db.org/network/9606.ENSP00000475615Spliceosome-associated protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome an [...]
DUSP13 protein networkhttps://string-db.org/network/9606.ENSP00000475626Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activi [...]
TM2D1 protein networkhttps://string-db.org/network/9606.ENSP00000475700TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42.
CSNK1G1 protein networkhttps://string-db.org/network/9606.ENSP00000475724Casein kinase I isoform gamma-1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...]
TBC1D7 protein networkhttps://string-db.org/network/9606.ENSP00000475727TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protei [...]
HEBP2 protein networkhttps://string-db.org/network/9606.ENSP00000475750Heme-binding protein 2; Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.
H2AC19 protein networkhttps://string-db.org/network/9606.ENSP00000475814H2A clustered histone 19.
CDC42SE1 protein networkhttps://string-db.org/network/9606.ENSP00000475845CDC42 small effector protein 1; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape ch [...]
CNKSR3 protein networkhttps://string-db.org/network/9606.ENSP00000475915Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport throug [...]
POLDIP2 protein networkhttps://string-db.org/network/9606.ENSP00000475924Polymerase delta-interacting protein 2; Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act [...]
DNAH11 protein networkhttps://string-db.org/network/9606.ENSP00000475939Dynein heavy chain 11, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
U3KQK5_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000475957Uncharacterized protein.
ACYP2 protein networkhttps://string-db.org/network/9606.ENSP00000475986Acylphosphatase-2; Its physiological role is not yet clear.
U3KQP1_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000476091Uncharacterized protein.
GTF2H5 protein networkhttps://string-db.org/network/9606.ENSP00000476100General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotid [...]
WDR18 protein networkhttps://string-db.org/network/9606.ENSP00000476117WD repeat-containing protein 18; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoyla [...]
NUDT3 protein networkhttps://string-db.org/network/9606.ENSP00000476119Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol t [...]
H2BC11 protein networkhttps://string-db.org/network/9606.ENSP00000476136Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
UQCC2 protein networkhttps://string-db.org/network/9606.ENSP00000476140Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...]
MT1HL1 protein networkhttps://string-db.org/network/9606.ENSP00000476141Metallothionein 1H-like protein 1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals an [...]
FRK protein networkhttps://string-db.org/network/9606.ENSP00000476145Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr [...]
SLC37A4 protein networkhttps://string-db.org/network/9606.ENSP00000476176Glucose-6-phosphate exchanger SLC37A4; Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endopl [...]
SIRT5 protein networkhttps://string-db.org/network/9606.ENSP00000476228NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on tar [...]
U3KQV3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000476252PPM-type phosphatase domain-containing protein.
SRRM5 protein networkhttps://string-db.org/network/9606.ENSP00000476253Serine/arginine repetitive matrix 5.
CDYL2 protein networkhttps://string-db.org/network/9606.ENSP00000476295Chromodomain Y like 2.
BHLHA15 protein networkhttps://string-db.org/network/9606.ENSP00000476312Class A basic helix-loop-helix protein 15; Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may [...]
FBXW2 protein networkhttps://string-db.org/network/9606.ENSP00000476369F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
SCX protein networkhttps://string-db.org/network/9606.ENSP00000476384Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.
DCP1A protein networkhttps://string-db.org/network/9606.ENSP00000476386mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, [...]
CHMP4A protein networkhttps://string-db.org/network/9606.ENSP00000476412Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...]
NT5C3A protein networkhttps://string-db.org/network/9606.ENSP00000476480Cytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrat [...]
ZBTB8B protein networkhttps://string-db.org/network/9606.ENSP00000476499Zinc finger and BTB domain-containing protein 8B; May be involved in transcriptional regulation.
LYPD4 protein networkhttps://string-db.org/network/9606.ENSP00000476510LY6/PLAUR domain containing 4.
KCNN1 protein networkhttps://string-db.org/network/9606.ENSP00000476519Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...]
GPRIN3 protein networkhttps://string-db.org/network/9606.ENSP00000476603G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth.
RPEL1 protein networkhttps://string-db.org/network/9606.ENSP00000476672Ribulose-phosphate 3-epimerase-like protein 1; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family.
V9GYH0_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000476742Homeobox domain-containing protein.
ZBTB25 protein networkhttps://string-db.org/network/9606.ENSP00000476746Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation.
RTL5 protein networkhttps://string-db.org/network/9606.ENSP00000476792Retrotransposon Gag like 5.
SLC25A16 protein networkhttps://string-db.org/network/9606.ENSP00000476815Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family.
TRABD2B protein networkhttps://string-db.org/network/9606.ENSP00000476820Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following [...]
KRTAP10-7 protein networkhttps://string-db.org/network/9606.ENSP00000476821Keratin-associated protein 10-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
RPAP2 protein networkhttps://string-db.org/network/9606.ENSP00000476948Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphoryl [...]
OR8G5 protein networkhttps://string-db.org/network/9606.ENSP00000477014Olfactory receptor 8G5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SMIM5 protein networkhttps://string-db.org/network/9606.ENSP00000477017Small integral membrane protein 5.
V9GYS6_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000477043KRAB domain-containing protein.
XKR7 protein networkhttps://string-db.org/network/9606.ENSP00000477059XK-related protein 7; XK related 7.
V9GYV3_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000477118Uncharacterized protein.
FRRS1L protein networkhttps://string-db.org/network/9606.ENSP00000477141DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway.
APBB1 protein networkhttps://string-db.org/network/9606.ENSP00000477213Amyloid-beta A4 precursor protein-binding family B member 1; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally act [...]
OR8J1 protein networkhttps://string-db.org/network/9606.ENSP00000477259Olfactory receptor 8J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DYNLL2 protein networkhttps://string-db.org/network/9606.ENSP00000477310Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to [...]
PCDHB16 protein networkhttps://string-db.org/network/9606.ENSP00000477314Protocadherin beta-16; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
PPM1K protein networkhttps://string-db.org/network/9606.ENSP00000477341Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
SYT6 protein networkhttps://string-db.org/network/9606.ENSP00000477344Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...]
SCOC protein networkhttps://string-db.org/network/9606.ENSP00000477352Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family.
ZNF595 protein networkhttps://string-db.org/network/9606.ENSP00000477392Zinc finger protein 595; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
KCNJ6 protein networkhttps://string-db.org/network/9606.ENSP00000477437G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G- prote [...]
OR10G6 protein networkhttps://string-db.org/network/9606.ENSP00000477445Olfactory receptor 10G6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GRIN2B protein networkhttps://string-db.org/network/9606.ENSP00000477455Glutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...]
NOMO2 protein networkhttps://string-db.org/network/9606.ENSP00000477502Nodal modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN.
RIOX1 protein networkhttps://string-db.org/network/9606.ENSP00000477507Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of his [...]
NBPF11 protein networkhttps://string-db.org/network/9606.ENSP00000477509Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family.
DGKK protein networkhttps://string-db.org/network/9606.ENSP00000477515Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).
H2BC17 protein networkhttps://string-db.org/network/9606.ENSP00000477527Histone H2B type 1-O; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
F8A3 protein networkhttps://string-db.org/network/9606.ENSP00000477530Coagulation factor VIII associated 3.
NAP1L1 protein networkhttps://string-db.org/network/9606.ENSP00000477538Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differen [...]
HCRTR2 protein networkhttps://string-db.org/network/9606.ENSP00000477548Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
MR1 protein networkhttps://string-db.org/network/9606.ENSP00000477563Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of [...]
CYP4F8 protein networkhttps://string-db.org/network/9606.ENSP00000477567Cytochrome P450 4F8; A cytochrome P450 monooxygenase involved in the metabolism of endogenous polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives (oxylipins). Mechanistically, us [...]
HMOX2 protein networkhttps://string-db.org/network/9606.ENSP00000477572Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiologic [...]
SRD5A2 protein networkhttps://string-db.org/network/9606.ENSP000004775873-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It pl [...]
CPNE3 protein networkhttps://string-db.org/network/9606.ENSP00000477590Copine-3; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation. Belongs to the copine family.
MROH2A protein networkhttps://string-db.org/network/9606.ENSP00000477597Maestro heat like repeat family member 2A.
ELOVL1 protein networkhttps://string-db.org/network/9606.ENSP00000477602Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endopla [...]
BIRC2 protein networkhttps://string-db.org/network/9606.ENSP00000477613Baculoviral IAP repeat-containing protein 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase sig [...]
TMC4 protein networkhttps://string-db.org/network/9606.ENSP00000477627Transmembrane channel-like protein 4; Probable ion channel.
NAGK protein networkhttps://string-db.org/network/9606.ENSP00000477639N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosph [...]
LYNX1 protein networkhttps://string-db.org/network/9606.ENSP00000477648Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent [...]
DUSP14 protein networkhttps://string-db.org/network/9606.ENSP00000477653Dual specificity protein phosphatase 14; Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases; Belongs to the protein-tyrosine phosphatase family. Non- recep [...]
C18orf54 protein networkhttps://string-db.org/network/9606.ENSP00000477654Chromosome 18 open reading frame 54.
TBC1D3F protein networkhttps://string-db.org/network/9606.ENSP00000477679TBC1 domain family member 3F.
ANKRD20A1 protein networkhttps://string-db.org/network/9606.ENSP00000477695Ankyrin repeat domain-containing protein 20A1; Ankyrin repeat domain 20 family member A1.
ZNF316 protein networkhttps://string-db.org/network/9606.ENSP00000477706Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NR1H3 protein networkhttps://string-db.org/network/9606.ENSP00000477707Oxysterols receptor LXR-alpha; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a s [...]
LCK protein networkhttps://string-db.org/network/9606.ENSP00000477713Tyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T- [...]
CPEB1 protein networkhttps://string-db.org/network/9606.ENSP00000477715Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, e [...]
ZNF8 protein networkhttps://string-db.org/network/9606.ENSP00000477716Zinc finger protein 8; Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins. Belongs to the krueppel C2H2-type zinc-finger prot [...]
KANK1 protein networkhttps://string-db.org/network/9606.ENSP00000477725KN motif and ankyrin repeat domain-containing protein 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. I [...]
ANAPC16 protein networkhttps://string-db.org/network/9606.ENSP00000477760Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
TPT1 protein networkhttps://string-db.org/network/9606.ENSP00000477781Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization.
LRRC41 protein networkhttps://string-db.org/network/9606.ENSP00000477792Leucine-rich repeat-containing protein 41; Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination an [...]
GCH1 protein networkhttps://string-db.org/network/9606.ENSP00000477796GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. [...]
C1orf158 protein networkhttps://string-db.org/network/9606.ENSP00000477802Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158.
PTCRA protein networkhttps://string-db.org/network/9606.ENSP00000477815Pre T-cell antigen receptor alpha; The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development.
PTPDC1 protein networkhttps://string-db.org/network/9606.ENSP00000477817Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance. Belongs to the protein-tyrosine phosphatase family. Non- receptor class PTPDC1 subf [...]
LHX1 protein networkhttps://string-db.org/network/9606.ENSP00000477829LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis.
ZNF282 protein networkhttps://string-db.org/network/9606.ENSP00000477841Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'- TCCACCCC-3' sequence as a core motif and e [...]
CLEC18C protein networkhttps://string-db.org/network/9606.ENSP00000477846C-type lectin domain family 18 member C; Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.
AATF protein networkhttps://string-db.org/network/9606.ENSP00000477848Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F tar [...]
GGTLC3 protein networkhttps://string-db.org/network/9606.ENSP00000477856Gamma-glutamyltransferase light chain family member 3.
TOX4 protein networkhttps://string-db.org/network/9606.ENSP00000477868TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transitio [...]
H4C7 protein networkhttps://string-db.org/network/9606.ENSP00000477870Histone H4-like protein type G; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a templa [...]
TMEM265 protein networkhttps://string-db.org/network/9606.ENSP00000477871Transmembrane protein 265.
KCNE1B protein networkhttps://string-db.org/network/9606.ENSP00000477875Potassium voltage-gated channel subfamily E regulatory subunit 1B.
ARID3B protein networkhttps://string-db.org/network/9606.ENSP00000477878AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.
H2BC14 protein networkhttps://string-db.org/network/9606.ENSP00000477907Histone H2B type 1-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
CCL3 protein networkhttps://string-db.org/network/9606.ENSP00000477908C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-a [...]
GIMAP1-GIMAP5 protein networkhttps://string-db.org/network/9606.ENSP00000477920GIMAP1-GIMAP5 readthrough.
SSX2B protein networkhttps://string-db.org/network/9606.ENSP00000477922SSX family member 2B.
STAG3 protein networkhttps://string-db.org/network/9606.ENSP00000477973Cohesin subunit SA-3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently fo [...]
NBPF9 protein networkhttps://string-db.org/network/9606.ENSP00000477979Neuroblastoma breakpoint family member 9; NBPF member 9; Belongs to the NBPF family.
SLC25A14 protein networkhttps://string-db.org/network/9606.ENSP00000477981Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family.
NOS1 protein networkhttps://string-db.org/network/9606.ENSP00000477999Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many pro [...]
HNRNPCL3 protein networkhttps://string-db.org/network/9606.ENSP00000478017Heterogeneous nuclear ribonucleoprotein C like 3.
CCL16 protein networkhttps://string-db.org/network/9606.ENSP00000478024C-C motif chemokine 16; Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor c [...]
ANXA8 protein networkhttps://string-db.org/network/9606.ENSP00000478026Annexin A8.
LOC107987373 protein networkhttps://string-db.org/network/9606.ENSP0000047803539S ribosomal protein L23, mitochondrial.
STIM1 protein networkhttps://string-db.org/network/9606.ENSP00000478059Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endo [...]
MARCKS protein networkhttps://string-db.org/network/9606.ENSP00000478061Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F [...]
CWC25 protein networkhttps://string-db.org/network/9606.ENSP00000478070Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family.
VPS13D protein networkhttps://string-db.org/network/9606.ENSP00000478104Vacuolar protein sorting-associated protein 13D; Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fissio [...]
ELOC protein networkhttps://string-db.org/network/9606.ENSP00000478121Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...]
CASP8AP2 protein networkhttps://string-db.org/network/9606.ENSP00000478179CASP8-associated protein 2; Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- [...]
CRY2 protein networkhttps://string-db.org/network/9606.ENSP00000478187Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes thro [...]
AKAP1 protein networkhttps://string-db.org/network/9606.ENSP00000478212A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane.
GGNBP2 protein networkhttps://string-db.org/network/9606.ENSP00000478220Gametogenetin-binding protein 2; May be involved in spermatogenesis.
ENSP00000478249 protein networkhttps://string-db.org/network/9606.ENSP00000478249Uncharacterized protein.
MTHFD1L protein networkhttps://string-db.org/network/9606.ENSP00000478253Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon fol [...]
ABCB1 protein networkhttps://string-db.org/network/9606.ENSP00000478255ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membran [...]
CCNI2 protein networkhttps://string-db.org/network/9606.ENSP00000478257Cyclin-I2; Cyclin I family member 2.
PCDHGB5 protein networkhttps://string-db.org/network/9606.ENSP00000478258Protocadherin gamma-B5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
LOC102723407 protein networkhttps://string-db.org/network/9606.ENSP00000478289Immunoglobulin heavy variable 4-38-2; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are m [...]
SRGAP2C protein networkhttps://string-db.org/network/9606.ENSP00000478290SLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases [...]
SPPL2B protein networkhttps://string-db.org/network/9606.ENSP00000478298Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and [...]
POLR2E protein networkhttps://string-db.org/network/9606.ENSP00000478303DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...]
SMOX protein networkhttps://string-db.org/network/9606.ENSP00000478305Spermine oxidase; Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isof [...]
ZNF714 protein networkhttps://string-db.org/network/9606.ENSP00000478345Zinc finger protein 714; May be involved in transcriptional regulation.
GRIP2 protein networkhttps://string-db.org/network/9606.ENSP00000478352Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners a [...]
FOXI3 protein networkhttps://string-db.org/network/9606.ENSP00000478384Forkhead box protein I3; Possible transcriptional factor.
NATD1 protein networkhttps://string-db.org/network/9606.ENSP00000478388Protein NATD1; N-acetyltransferase domain containing 1.
TTI2 protein networkhttps://string-db.org/network/9606.ENSP00000478396TELO2-interacting protein 2; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein [...]
PPP6R2 protein networkhttps://string-db.org/network/9606.ENSP00000478417Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphory [...]
TBC1D3D protein networkhttps://string-db.org/network/9606.ENSP00000478426TBC1 domain family member 3D; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
PLCL2 protein networkhttps://string-db.org/network/9606.ENSP00000478458Inactive phospholipase C-like protein 2; May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.
TBC1D3B protein networkhttps://string-db.org/network/9606.ENSP00000478473TBC1 domain family member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
UBE2F protein networkhttps://string-db.org/network/9606.ENSP00000478474NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E [...]
GOLGA6L1 protein networkhttps://string-db.org/network/9606.ENSP00000478478Golgin subfamily A member 6-like protein 1; Golgin A6 family like 1; Belongs to the GOLGA6 family.
RAB18 protein networkhttps://string-db.org/network/9606.ENSP00000478479Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain develop [...]
YTHDF3 protein networkhttps://string-db.org/network/9606.ENSP00000478490YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency. M6A is a modification present at inter [...]
ANAPC10 protein networkhttps://string-db.org/network/9606.ENSP00000478501Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...]
ZNF787 protein networkhttps://string-db.org/network/9606.ENSP00000478557Zinc finger protein 787; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CYP1B1 protein networkhttps://string-db.org/network/9606.ENSP00000478561Cytochrome P450 1B1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molec [...]
GAGE2E protein networkhttps://string-db.org/network/9606.ENSP00000478568G antigen 2E.
TTC25 protein networkhttps://string-db.org/network/9606.ENSP00000478589Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility.
NEURL3 protein networkhttps://string-db.org/network/9606.ENSP00000478591E3 ubiquitin-protein ligase NEURL3; E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not invo [...]
P3H3 protein networkhttps://string-db.org/network/9606.ENSP00000478600Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-l [...]
PCDHB9 protein networkhttps://string-db.org/network/9606.ENSP00000478606Protocadherin beta-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
NBPF12 protein networkhttps://string-db.org/network/9606.ENSP00000478609Neuroblastoma breakpoint family member 12; NBPF member 12.
SYT16 protein networkhttps://string-db.org/network/9606.ENSP00000478637Synaptotagmin-16; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
SLC1A7 protein networkhttps://string-db.org/network/9606.ENSP00000478639Excitatory amino acid transporter 5; Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate [...]
ICA1L protein networkhttps://string-db.org/network/9606.ENSP00000478645Islet cell autoantigen 1 like.
CNTNAP3B protein networkhttps://string-db.org/network/9606.ENSP00000478671Contactin-associated protein-like 3B; Contactin associated protein family member 3B; Belongs to the neurexin family.
RAG2 protein networkhttps://string-db.org/network/9606.ENSP00000478672V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles [...]
TBC1D3 protein networkhttps://string-db.org/network/9606.ENSP00000478683TBC1 domain family member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.
TNFRSF9 protein networkhttps://string-db.org/network/9606.ENSP00000478699Tumor necrosis factor receptor superfamily member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
RYK protein networkhttps://string-db.org/network/9606.ENSP00000478721Tyrosine-protein kinase RYK; May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establish [...]
IGHV3-16 protein networkhttps://string-db.org/network/9606.ENSP00000478725Probable non-functional immunoglobulin heavy variable 3-16; Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin heavy chains. Non-functional ORF [...]
NBPF19-2 protein networkhttps://string-db.org/network/9606.ENSP00000478752Neuroblastoma breakpoint family member 19; Belongs to the NBPF family.
DDX6 protein networkhttps://string-db.org/network/9606.ENSP00000478754Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-rela [...]
SEC14L2 protein networkhttps://string-db.org/network/9606.ENSP00000478755SEC14-like protein 2; Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also bin [...]
SIRPA protein networkhttps://string-db.org/network/9606.ENSP00000478763Tyrosine-protein phosphatase non-receptor type substrate 1; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other bindin [...]
NDUFC2-KCTD14 protein networkhttps://string-db.org/network/9606.ENSP00000478766NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2; NDUFC2-KCTD14 readthrough.
PPP1R9B protein networkhttps://string-db.org/network/9606.ENSP00000478767Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and sh [...]
UBB protein networkhttps://string-db.org/network/9606.ENSP00000478771Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either [...]
LTN1 protein networkhttps://string-db.org/network/9606.ENSP00000478783E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extractio [...]
LOC102723502 protein networkhttps://string-db.org/network/9606.ENSP00000478796POTE ankyrin domain family member B3.
TMPRSS7 protein networkhttps://string-db.org/network/9606.ENSP00000478830Transmembrane protease serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position; Belongs to the peptidase S1 family.
TEX28 protein networkhttps://string-db.org/network/9606.ENSP00000478834Testis-specific protein TEX28; Testis expressed 28.
CAMK1D protein networkhttps://string-db.org/network/9606.ENSP00000478874Calcium/calmodulin-dependent protein kinase type 1D; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, act [...]
ADRM1 protein networkhttps://string-db.org/network/9606.ENSP00000478877Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
CPNE4 protein networkhttps://string-db.org/network/9606.ENSP00000478878Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family.
C17orf78 protein networkhttps://string-db.org/network/9606.ENSP00000478886Uncharacterized protein C17orf78; Chromosome 17 open reading frame 78.
MYC protein networkhttps://string-db.org/network/9606.ENSP00000478887Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth [...]
GNAZ protein networkhttps://string-db.org/network/9606.ENSP00000478892Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
IGHD protein networkhttps://string-db.org/network/9606.ENSP00000478893Immunoglobulin heavy constant delta; Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocy [...]
MAFIP protein networkhttps://string-db.org/network/9606.ENSP00000478910MAFF interacting protein.
YAP1 protein networkhttps://string-db.org/network/9606.ENSP00000478927Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway t [...]
AIFM2 protein networkhttps://string-db.org/network/9606.ENSP00000478931Ferroptosis suppressor protein 1; A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubi [...]
LOC102724488 protein networkhttps://string-db.org/network/9606.ENSP00000478933Uncharacterized protein.
ZNF724-2 protein networkhttps://string-db.org/network/9606.ENSP00000478939Zinc finger protein 724.
UPK1A protein networkhttps://string-db.org/network/9606.ENSP00000478942Uroplakin-1a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal blad [...]
CBY1 protein networkhttps://string-db.org/network/9606.ENSP00000478962Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF tra [...]
RPP38 protein networkhttps://string-db.org/network/9606.ENSP00000478982Ribonuclease P protein subunit p38; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclea [...]
GPHB5 protein networkhttps://string-db.org/network/9606.ENSP00000478993Glycoprotein hormone beta-5; Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP prod [...]
IGKV1-33 protein networkhttps://string-db.org/network/9606.ENSP00000479032Immunoglobulin kappa variable 1-33; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
CCDC28A protein networkhttps://string-db.org/network/9606.ENSP00000479060Coiled-coil domain containing 28A.
ENSP00000479064 protein networkhttps://string-db.org/network/9606.ENSP00000479064Uncharacterized protein.
ELOA3B protein networkhttps://string-db.org/network/9606.ENSP00000479069Elongin-A3 member B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. [...]
ZFAND6 protein networkhttps://string-db.org/network/9606.ENSP00000479071AN1-type zinc finger protein 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and d [...]
OSCAR protein networkhttps://string-db.org/network/9606.ENSP00000479089Osteoclast-associated immunoglobulin-like receptor; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation; Belongs to the leukocyte recepto [...]
CCL14 protein networkhttps://string-db.org/network/9606.ENSP00000479097C-C motif chemokine 14; Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxi [...]
SVOP protein networkhttps://string-db.org/network/9606.ENSP00000479104Synaptic vesicle 2-related protein; SV2 related protein.
H4C1 protein networkhttps://string-db.org/network/9606.ENSP00000479106H4 clustered histone 1.
GABRG3 protein networkhttps://string-db.org/network/9606.ENSP00000479113Gamma-aminobutyric acid receptor subunit gamma-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...]
IGHV1-3 protein networkhttps://string-db.org/network/9606.ENSP00000479119Immunoglobulin heavy variable 1-3; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are memb [...]
ACSF3 protein networkhttps://string-db.org/network/9606.ENSP00000479130Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respec [...]
FMN1 protein networkhttps://string-db.org/network/9606.ENSP00000479134Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables; Belongs to the formin homology family. Cappuccino subfamily.
LOC100288966 protein networkhttps://string-db.org/network/9606.ENSP00000479139POTE ankyrin domain family member D-like.
EHD1 protein networkhttps://string-db.org/network/9606.ENSP00000479153EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts i [...]
HOXA4 protein networkhttps://string-db.org/network/9606.ENSP00000479166Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
PRH1 protein networkhttps://string-db.org/network/9606.ENSP00000479168Proline rich protein HaeIII subfamily 1.
H2BC9 protein networkhttps://string-db.org/network/9606.ENSP00000479169Histone H2B type 1-H; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
ARL8B protein networkhttps://string-db.org/network/9606.ENSP00000479202ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long- range transport of presynaptic lysosome-related vesicles required for [...]
HNRNPCL2 protein networkhttps://string-db.org/network/9606.ENSP00000479203Heterogeneous nuclear ribonucleoprotein C-like 2; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs.
GALNTL5 protein networkhttps://string-db.org/network/9606.ENSP00000479207Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acr [...]
UBXN8 protein networkhttps://string-db.org/network/9606.ENSP00000479216UBX domain-containing protein 8; Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. M [...]
PINLYP protein networkhttps://string-db.org/network/9606.ENSP00000479240Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family.
ECSCR protein networkhttps://string-db.org/network/9606.ENSP00000479243Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilita [...]
JAKMIP2 protein networkhttps://string-db.org/network/9606.ENSP00000479248Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family.
TRIL protein networkhttps://string-db.org/network/9606.ENSP00000479256TLR4 interactor with leucine rich repeats; Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.
UNC13B protein networkhttps://string-db.org/network/9606.ENSP00000479261Protein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in syn [...]
BORA protein networkhttps://string-db.org/network/9606.ENSP00000479266Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis.
H2BU1 protein networkhttps://string-db.org/network/9606.ENSP00000479284Histone H2B type 3-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
NBPF20 protein networkhttps://string-db.org/network/9606.ENSP00000479291Neuroblastoma breakpoint family member 20; NBPF member 20; Belongs to the NBPF family.
CLIP1 protein networkhttps://string-db.org/network/9606.ENSP00000479322CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. [...]
RIMBP3B protein networkhttps://string-db.org/network/9606.ENSP00000479326RIMS-binding protein 3B; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development.
LENG9 protein networkhttps://string-db.org/network/9606.ENSP00000479355Leukocyte receptor cluster member 9.
GOLGA6L10 protein networkhttps://string-db.org/network/9606.ENSP00000479362Golgin subfamily A member 6-like protein 10; Golgin A6 family like 10; Belongs to the GOLGA6 family.
GUCD1 protein networkhttps://string-db.org/network/9606.ENSP00000479370Protein GUCD1; Guanylyl cyclase domain containing 1.
LOC102723655 protein networkhttps://string-db.org/network/9606.ENSP00000479378TP53-target gene 3 protein.
C17orf98 protein networkhttps://string-db.org/network/9606.ENSP00000479396Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98.
C10orf142 protein networkhttps://string-db.org/network/9606.ENSP00000479444Uncharacterized protein C10orf142.
ZNF700 protein networkhttps://string-db.org/network/9606.ENSP00000479449Zinc finger protein 700; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
H4C4 protein networkhttps://string-db.org/network/9606.ENSP00000479461H4 clustered histone 4.
PHB protein networkhttps://string-db.org/network/9606.ENSP00000479488Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitoc [...]
PCID2 protein networkhttps://string-db.org/network/9606.ENSP00000479494PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a [...]
DDX52 protein networkhttps://string-db.org/network/9606.ENSP00000479504Probable ATP-dependent RNA helicase DDX52; DExD-box helicase 52; Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
MYO19 protein networkhttps://string-db.org/network/9606.ENSP00000479518Unconventional myosin-XIX; Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments (By [...]
DPF3 protein networkhttps://string-db.org/network/9606.ENSP00000479526Zinc finger protein DPF3; Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodel [...]
CD177 protein networkhttps://string-db.org/network/9606.ENSP00000479536CD177 antigen; In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. I [...]
KIZ protein networkhttps://string-db.org/network/9606.ENSP00000479542Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle forma [...]
GIMAP6 protein networkhttps://string-db.org/network/9606.ENSP00000479580GTPase, IMAP family member 6.
LYNX1-SLURP2 protein networkhttps://string-db.org/network/9606.ENSP00000479586LYNX1-SLURP2 readthrough.
RHNO1 protein networkhttps://string-db.org/network/9606.ENSP00000479598RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to [...]
CLTC protein networkhttps://string-db.org/network/9606.ENSP00000479606Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma me [...]
CT45A6 protein networkhttps://string-db.org/network/9606.ENSP00000479608Cancer/testis antigen family 45 member A6.
UHRF1 protein networkhttps://string-db.org/network/9606.ENSP00000479617E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethyl [...]
F8A1 protein networkhttps://string-db.org/network/9606.ENSP00000479624Coagulation factor VIII associated 1.
PLCD3 protein networkhttps://string-db.org/network/9606.ENSP000004796361-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and in [...]
KRTAP7-1 protein networkhttps://string-db.org/network/9606.ENSP00000479656Keratin-associated protein 7-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which [...]
AOAH protein networkhttps://string-db.org/network/9606.ENSP00000479664Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the ho [...]
RPS6KA5 protein networkhttps://string-db.org/network/9606.ENSP00000479667Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the reg [...]
CAB39L protein networkhttps://string-db.org/network/9606.ENSP00000479669Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO [...]
IGHV3-15 protein networkhttps://string-db.org/network/9606.ENSP00000479675Immunoglobulin heavy variable 3-15; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
KCP protein networkhttps://string-db.org/network/9606.ENSP00000479679Kielin/chordin-like protein; Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By simil [...]
NBPF14 protein networkhttps://string-db.org/network/9606.ENSP00000479693Neuroblastoma breakpoint family member 14; NBPF member 14.
MAL2 protein networkhttps://string-db.org/network/9606.ENSP00000479708Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order [...]
DNAJC28 protein networkhttps://string-db.org/network/9606.ENSP00000479716DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone.
CYFIP2 protein networkhttps://string-db.org/network/9606.ENSP00000479719Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 en [...]
LRCOL1 protein networkhttps://string-db.org/network/9606.ENSP00000479730Leucine-rich colipase-like protein 1; Leucine rich colipase like 1.
RAPGEFL1 protein networkhttps://string-db.org/network/9606.ENSP00000479735Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF).
PRSS56 protein networkhttps://string-db.org/network/9606.ENSP00000479745Serine protease 56; Serine protease required during eye development.
GCSAML-AS1 protein networkhttps://string-db.org/network/9606.ENSP00000479757Olfactory receptor 2C3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
RAB7B protein networkhttps://string-db.org/network/9606.ENSP00000479762Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, I [...]
CFAP57 protein networkhttps://string-db.org/network/9606.ENSP00000479773Cilia and flagella associated protein 57.
H4C12 protein networkhttps://string-db.org/network/9606.ENSP00000479794H4 clustered histone 12.
CNTNAP4 protein networkhttps://string-db.org/network/9606.ENSP00000479811Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory [...]
DENND1B protein networkhttps://string-db.org/network/9606.ENSP00000479816DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchang [...]
RASGRP4 protein networkhttps://string-db.org/network/9606.ENSP00000479844RAS guanyl-releasing protein 4; Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast [...]
ALG1L2 protein networkhttps://string-db.org/network/9606.ENSP00000479850Putative glycosyltransferase ALG1L2; Putative glycosyltransferase.
CIB1 protein networkhttps://string-db.org/network/9606.ENSP00000479860Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation [...]
SEPTIN2 protein networkhttps://string-db.org/network/9606.ENSP00000479861Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integr [...]
ALOX5AP protein networkhttps://string-db.org/network/9606.ENSP00000479870Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essentia [...]
ZNF229 protein networkhttps://string-db.org/network/9606.ENSP00000479884Zinc finger protein 229; May be involved in transcriptional regulation.
IRAK4 protein networkhttps://string-db.org/network/9606.ENSP00000479889Interleukin-1 receptor-associated kinase 4; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like recept [...]
ZMYM2 protein networkhttps://string-db.org/network/9606.ENSP00000479904Zinc finger MYM-type protein 2; May function as a transcription factor.
MLLT6 protein networkhttps://string-db.org/network/9606.ENSP00000479910Protein AF-17; MLLT6, PHD finger containing.
SH3GLB1 protein networkhttps://string-db.org/network/9606.ENSP00000479919Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins t [...]
ENSP00000479921 protein networkhttps://string-db.org/network/9606.ENSP00000479921annotation not available
LRRC8E protein networkhttps://string-db.org/network/9606.ENSP00000479953Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...]
CCL18 protein networkhttps://string-db.org/network/9606.ENSP00000479955C-C motif chemokine 18; Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B- cell follicles in lymph nodes. Attracts naive T [...]
SLC4A1AP protein networkhttps://string-db.org/network/9606.ENSP00000479964Kanadaptin; Solute carrier family 4 member 1 adaptor protein.
ANGPTL8 protein networkhttps://string-db.org/network/9606.ENSP00000479969Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: requi [...]
C11orf96 protein networkhttps://string-db.org/network/9606.ENSP00000479976Uncharacterized protein C11orf96; Chromosome 11 open reading frame 96.
EPHX1 protein networkhttps://string-db.org/network/9606.ENSP00000480004Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By [...]
ADORA2A protein networkhttps://string-db.org/network/9606.ENSP00000480012Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity); Belongs to the G-protein c [...]
PRAMEF11 protein networkhttps://string-db.org/network/9606.ENSP00000480027PRAME family member 11; Belongs to the PRAME family.
IGHV3-72 protein networkhttps://string-db.org/network/9606.ENSP00000480035Immunoglobulin heavy variable 3-72; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are mem [...]
VEGFC protein networkhttps://string-db.org/network/9606.ENSP00000480043Vascular endothelial growth factor C; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of [...]
SYN2 protein networkhttps://string-db.org/network/9606.ENSP00000480050Synapsin-2; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradren [...]
GPIHBP1 protein networkhttps://string-db.org/network/9606.ENSP00000480053Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells [...]
METTL8 protein networkhttps://string-db.org/network/9606.ENSP00000480056mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.
P3R3URF protein networkhttps://string-db.org/network/9606.ENSP00000480059PIK3R3 upstream reading frame.
PKD1L3 protein networkhttps://string-db.org/network/9606.ENSP00000480090Polycystic kidney disease protein 1-like 3; Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution [...]
NMRK2 protein networkhttps://string-db.org/network/9606.ENSP00000480091Nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucl [...]
PRAMEF5 protein networkhttps://string-db.org/network/9606.ENSP00000480122PRAME family member 5; Belongs to the PRAME family.
NCAM1 protein networkhttps://string-db.org/network/9606.ENSP00000480132Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
SRSF8 protein networkhttps://string-db.org/network/9606.ENSP00000480140Serine/arginine-rich splicing factor 8; Involved in pre-mRNA alternative splicing.
HYOU1 protein networkhttps://string-db.org/network/9606.ENSP00000480150Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein foldi [...]
PIK3R6 protein networkhttps://string-db.org/network/9606.ENSP00000480157Phosphoinositide 3-kinase regulatory subunit 6; Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 he [...]
POLD2 protein networkhttps://string-db.org/network/9606.ENSP00000480186DNA polymerase delta subunit 2; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delt [...]
ANXA8L1 protein networkhttps://string-db.org/network/9606.ENSP00000480221Annexin A8 like 1; Belongs to the annexin family.
LRMDA protein networkhttps://string-db.org/network/9606.ENSP00000480240Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation.
PPP1R18 protein networkhttps://string-db.org/network/9606.ENSP00000480270Phostensin; [Isoform 1]: May target protein phosphatase 1 to F-actin cytoskeleton.
USH1G protein networkhttps://string-db.org/network/9606.ENSP00000480279Usher syndrome type-1G protein; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH [...]
HNF1B protein networkhttps://string-db.org/network/9606.ENSP00000480291Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
IQSEC1 protein networkhttps://string-db.org/network/9606.ENSP00000480301IQ motif and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP bind [...]
GATD3B protein networkhttps://string-db.org/network/9606.ENSP00000480313Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial; Glutamine amidotransferase like class 1 domain containing 3B; Belongs to the GATD3 family.
ZSWIM9 protein networkhttps://string-db.org/network/9606.ENSP00000480314Uncharacterized protein ZSWIM9; Zinc finger SWIM-type containing 9.
TUBGCP5 protein networkhttps://string-db.org/network/9606.ENSP00000480316Gamma-tubulin complex component 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
LOC102723532 protein networkhttps://string-db.org/network/9606.ENSP00000480318Olfactory receptor.
CD99L2 protein networkhttps://string-db.org/network/9606.ENSP00000480322CD99 antigen-like protein 2; Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PE [...]
TRAPPC3 protein networkhttps://string-db.org/network/9606.ENSP00000480332Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi.
SLC22A24 protein networkhttps://string-db.org/network/9606.ENSP00000480336Steroid transmembrane transporter SLC22A24; Steroid transmembrane transporter that functions in the reabsorption of conjugated steroids in the kidney and is involved in steroid homeostasis. [Isof [...]
CXorf49 protein networkhttps://string-db.org/network/9606.ENSP00000480355Uncharacterized protein CXorf49; Chromosome X open reading frame 49.
PDLIM5 protein networkhttps://string-db.org/network/9606.ENSP00000480359PDZ and LIM domain 5.
RCC1L protein networkhttps://string-db.org/network/9606.ENSP00000480364RCC1-like G exchanging factor-like protein; Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drive [...]
GOLGA6L6 protein networkhttps://string-db.org/network/9606.ENSP00000480376Golgin subfamily A member 6-like protein 6; Golgin A6 family like 6; Belongs to the GOLGA6 family.
MTERF4 protein networkhttps://string-db.org/network/9606.ENSP00000480378Transcription termination factor 4, mitochondrial; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA meth [...]
ZNF205 protein networkhttps://string-db.org/network/9606.ENSP00000480401Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GPR1 protein networkhttps://string-db.org/network/9606.ENSP00000480405G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Receptor f [...]
SRRT protein networkhttps://string-db.org/network/9606.ENSP00000480421Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to t [...]
B4GALT3 protein networkhttps://string-db.org/network/9606.ENSP00000480428Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
DHRS3 protein networkhttps://string-db.org/network/9606.ENSP00000480439Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH.
HSD11B1L protein networkhttps://string-db.org/network/9606.ENSP00000480443Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Hydroxysteroid 11-beta dehydrogenase 1 like; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
MSANTD3 protein networkhttps://string-db.org/network/9606.ENSP00000480445Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family.
IFNA13 protein networkhttps://string-db.org/network/9606.ENSP00000480467Interferon alpha 13.
COL19A1 protein networkhttps://string-db.org/network/9606.ENSP00000480474Collagen alpha-1(XIX) chain; May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in or [...]
OPLAH protein networkhttps://string-db.org/network/9606.ENSP000004804765-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate; Belongs to the oxoprolinase family.
NRN1 protein networkhttps://string-db.org/network/9606.ENSP00000480483Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
TCHH protein networkhttps://string-db.org/network/9606.ENSP00000480484Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the gran [...]
PDZD7 protein networkhttps://string-db.org/network/9606.ENSP00000480489PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated b [...]
TSPAN10 protein networkhttps://string-db.org/network/9606.ENSP00000480492Tetraspanin-10; Regulates maturation of the transmembrane metalloprotease ADAM10; Belongs to the tetraspanin (TM4SF) family.
TMCO1 protein networkhttps://string-db.org/network/9606.ENSP00000480514Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmi [...]
GTF2IRD2B protein networkhttps://string-db.org/network/9606.ENSP00000480524General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family.
ENSP00000480527 protein networkhttps://string-db.org/network/9606.ENSP00000480527Uncharacterized protein.
REXO2 protein networkhttps://string-db.org/network/9606.ENSP00000480535Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. M [...]
DNAI1 protein networkhttps://string-db.org/network/9606.ENSP00000480538Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family.
CDC42EP3 protein networkhttps://string-db.org/network/9606.ENSP00000480549Cdc42 effector protein 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...]
ZNF718 protein networkhttps://string-db.org/network/9606.ENSP00000480556Zinc finger protein 718; May be involved in transcriptional regulation.
CCL3L1 protein networkhttps://string-db.org/network/9606.ENSP00000480558C-C motif chemokine 3-like 1; Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fol [...]
ENSP00000480571 protein networkhttps://string-db.org/network/9606.ENSP00000480571Cytochrome P450 family 3 subfamily A polypeptide 7; CYP3A7-CYP3A51P readthrough.
ADRA2B protein networkhttps://string-db.org/network/9606.ENSP00000480573Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agoni [...]
OR52E5 protein networkhttps://string-db.org/network/9606.ENSP00000480583Olfactory receptor 52E5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CFAP99 protein networkhttps://string-db.org/network/9606.ENSP00000480601Cilia and flagella associated protein 99.
ANTXRL protein networkhttps://string-db.org/network/9606.ENSP00000480615Anthrax toxin receptor-like; ANTXR like.
PRDM11 protein networkhttps://string-db.org/network/9606.ENSP00000480626PR domain-containing protein 11; May be involved in transcription regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily.
C7orf77 protein networkhttps://string-db.org/network/9606.ENSP00000480627Uncharacterized protein C7orf77; Chromosome 7 open reading frame 77.
MAGEA6 protein networkhttps://string-db.org/network/9606.ENSP00000480637Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and [...]
SEMA3B protein networkhttps://string-db.org/network/9606.ENSP00000480680Semaphorin-3B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Belongs to the semaphorin family.
SLC46A1 protein networkhttps://string-db.org/network/9606.ENSP00000480703Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake fro [...]
COPZ2 protein networkhttps://string-db.org/network/9606.ENSP00000480707Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosyn [...]
IQCE protein networkhttps://string-db.org/network/9606.ENSP00000480715IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (By similarity). Required for proper limb morphogenesis.
NUDT18 protein networkhttps://string-db.org/network/9606.ENSP000004807228-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside dip [...]
LRRC39 protein networkhttps://string-db.org/network/9606.ENSP00000480740Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via [...]
ZNF385C protein networkhttps://string-db.org/network/9606.ENSP00000480744Zinc finger protein 385C.
ZAN protein networkhttps://string-db.org/network/9606.ENSP00000480750Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
EPHA5 protein networkhttps://string-db.org/network/9606.ENSP00000480763Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...]
FGF1 protein networkhttps://string-db.org/network/9606.ENSP00000480791Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. [...]
NDFIP2 protein networkhttps://string-db.org/network/9606.ENSP00000480798NEDD4 family-interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability o [...]
LOC102724250 protein networkhttps://string-db.org/network/9606.ENSP00000480818Neuroblastoma breakpoint family member 26.
LSR protein networkhttps://string-db.org/network/9606.ENSP00000480821Lipolysis-stimulated lipoprotein receptor; Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows [...]
PKIB protein networkhttps://string-db.org/network/9606.ENSP00000480824cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme aft [...]
H3C1 protein networkhttps://string-db.org/network/9606.ENSP00000480826H3 clustered histone 1.
BCL2L13 protein networkhttps://string-db.org/network/9606.ENSP00000480836Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis.
SRRM3 protein networkhttps://string-db.org/network/9606.ENSP00000480851Serine/arginine repetitive matrix protein 3; May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression ; Belongs to the CWC21 famil [...]
VPS29 protein networkhttps://string-db.org/network/9606.ENSP00000480853Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...]
ST3GAL6 protein networkhttps://string-db.org/network/9606.ENSP00000480884Type 2 lactosamine alpha-2,3-sialyltransferase; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Ga [...]
FNDC11 protein networkhttps://string-db.org/network/9606.ENSP00000480914Fibronectin type III domain containing 11.
SLC9A7 protein networkhttps://string-db.org/network/9606.ENSP00000480916Sodium/hydrogen exchanger 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH.
C18orf32 protein networkhttps://string-db.org/network/9606.ENSP00000480941UPF0729 protein C18orf32; May activate the NF-kappa-B signaling pathway.
SETSIP protein networkhttps://string-db.org/network/9606.ENSP00000480946Protein SETSIP; Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cell [...]
H4C13 protein networkhttps://string-db.org/network/9606.ENSP00000480960H4 clustered histone 13.
P2RY6 protein networkhttps://string-db.org/network/9606.ENSP00000480966P2Y purinoceptor 6; Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
SSTR3 protein networkhttps://string-db.org/network/9606.ENSP00000480971Somatostatin receptor type 3; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.
ZCCHC17 protein networkhttps://string-db.org/network/9606.ENSP00000480986Nucleolar protein of 40 kDa; Zinc finger CCHC-type containing 17.
MCM3 protein networkhttps://string-db.org/network/9606.ENSP00000480987DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...]
CHST9 protein networkhttps://string-db.org/network/9606.ENSP00000480991Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynth [...]
BHLHE23 protein networkhttps://string-db.org/network/9606.ENSP00000480998Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and ne [...]
PLP1 protein networkhttps://string-db.org/network/9606.ENSP00000481006Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; [...]
GAS2L1 protein networkhttps://string-db.org/network/9606.ENSP00000481012GAS2-like protein 1; Involved in the cross-linking of microtubules and microfilaments. Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, suc [...]
SEM1 protein networkhttps://string-db.org/network/9606.ENSP00000481021Putative protein SEM1, isoform 2; SEM1 26S proteasome complex subunit.
SCAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000481022Secretory carrier-associated membrane protein 1; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface.
PSMC3 protein networkhttps://string-db.org/network/9606.ENSP0000048102926S proteasome regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...]
CYFIP1 protein networkhttps://string-db.org/network/9606.ENSP00000481038Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subuni [...]
PHOSPHO2 protein networkhttps://string-db.org/network/9606.ENSP00000481046Pyridoxal phosphate phosphatase PHOSPHO2; Phosphatase that has high activity toward pyridoxal 5'- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), [...]
RAB44 protein networkhttps://string-db.org/network/9606.ENSP00000481054Ras-related protein Rab-44; RAB44, member RAS oncogene family.
FCGBP protein networkhttps://string-db.org/network/9606.ENSP00000481056IgGFc-binding protein; May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
GOLGA6L9 protein networkhttps://string-db.org/network/9606.ENSP00000481078Golgin subfamily A member 6-like protein 9; Golgin A6 family like 9.
TADA2A protein networkhttps://string-db.org/network/9606.ENSP00000481091Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domain [...]
MGAT4C protein networkhttps://string-db.org/network/9606.ENSP00000481096Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N- [...]
PRAG1 protein networkhttps://string-db.org/network/9606.ENSP00000481109Inactive tyrosine-protein kinase PRAG1; Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity an [...]
FOLR3 protein networkhttps://string-db.org/network/9606.ENSP00000481114Folate receptor gamma; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.
VPS11 protein networkhttps://string-db.org/network/9606.ENSP00000481126Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...]
LOC102724788 protein networkhttps://string-db.org/network/9606.ENSP00000481127Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.
ANKRD36B protein networkhttps://string-db.org/network/9606.ENSP00000481149Ankyrin repeat domain 36B; Belongs to the ANKRD36 family.
IGHV3-43D protein networkhttps://string-db.org/network/9606.ENSP00000481152Immunoglobulin heavy variable 3-43D; V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are me [...]
CT45A8 protein networkhttps://string-db.org/network/9606.ENSP00000481184Cancer/testis antigen family 45 member A8.
GRIFIN protein networkhttps://string-db.org/network/9606.ENSP00000481185Grifin; Galectin-related inter-fiber protein.
SHISA8 protein networkhttps://string-db.org/network/9606.ENSP00000481203Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses; Belongs to the shisa family.
FXYD1 protein networkhttps://string-db.org/network/9606.ENSP00000481244Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in [...]
SOCS2 protein networkhttps://string-db.org/network/9606.ENSP00000481249Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in [...]
ZNF761 protein networkhttps://string-db.org/network/9606.ENSP00000481271Zinc finger protein 761.
SLC38A3 protein networkhttps://string-db.org/network/9606.ENSP00000481301Sodium-coupled neutral amino acid transporter 3; Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recogn [...]
SPINK6 protein networkhttps://string-db.org/network/9606.ENSP00000481309Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
SMR3B protein networkhttps://string-db.org/network/9606.ENSP00000481313Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family.
SNX12 protein networkhttps://string-db.org/network/9606.ENSP00000481314Sorting nexin-12; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family.
ENSP00000481316 protein networkhttps://string-db.org/network/9606.ENSP00000481316KRAB domain-containing protein.
GABRR3 protein networkhttps://string-db.org/network/9606.ENSP00000481321Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...]
CCL23 protein networkhttps://string-db.org/network/9606.ENSP00000481357C-C motif chemokine 23; Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in [...]
TMEM191B protein networkhttps://string-db.org/network/9606.ENSP00000481358Transmembrane protein 191B.
CCNA2 protein networkhttps://string-db.org/network/9606.ENSP00000481380Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes w [...]
AMY2A protein networkhttps://string-db.org/network/9606.ENSP00000481450Pancreatic alpha-amylase; Amylase alpha 2A.
TRIM49B protein networkhttps://string-db.org/network/9606.ENSP00000481457Putative tripartite motif-containing protein 49B; Tripartite motif containing 49B; Belongs to the TRIM/RBCC family.
FAM83D protein networkhttps://string-db.org/network/9606.ENSP00000481465Protein FAM83D; Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the [...]
H4C9 protein networkhttps://string-db.org/network/9606.ENSP00000481486H4 clustered histone 9.
DDX24 protein networkhttps://string-db.org/network/9606.ENSP00000481495ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
NBPF26 protein networkhttps://string-db.org/network/9606.ENSP00000481542Neuroblastoma breakpoint family member 26; NBPF member 26.
GRIA3 protein networkhttps://string-db.org/network/9606.ENSP00000481554Glutamate receptor 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...]
MRM1 protein networkhttps://string-db.org/network/9606.ENSP00000481559rRNA methyltransferase 1, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S [...]
TNFAIP3 protein networkhttps://string-db.org/network/9606.ENSP00000481570Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled b [...]
ENSP00000481571 protein networkhttps://string-db.org/network/9606.ENSP00000481571Uncharacterized protein.
POM121C protein networkhttps://string-db.org/network/9606.ENSP00000481575Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to [...]
FOXD1 protein networkhttps://string-db.org/network/9606.ENSP00000481581Forkhead box protein D1; Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionaliza [...]
SMIM22 protein networkhttps://string-db.org/network/9606.ENSP00000481592Small integral membrane protein 22; May modulate lipid droplet formation throught interaction with SQLE.
HTD2 protein networkhttps://string-db.org/network/9606.ENSP00000481593Hydroxyacyl-thioester dehydratase type 2, mitochondrial; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis; Belongs to the HTD2 family.
OR56A5 protein networkhttps://string-db.org/network/9606.ENSP00000481594Olfactory receptor 56A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
POM121L1P protein networkhttps://string-db.org/network/9606.ENSP00000481613Putative POM121-like protein 1.
H2BS1 protein networkhttps://string-db.org/network/9606.ENSP00000481622Histone H2B type F-S; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
SLC6A6 protein networkhttps://string-db.org/network/9606.ENSP00000481625Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
C18orf25 protein networkhttps://string-db.org/network/9606.ENSP00000481626Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25.
IFNL3 protein networkhttps://string-db.org/network/9606.ENSP00000481633Interferon lambda-3; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...]
RPS10 protein networkhttps://string-db.org/network/9606.ENSP0000048164640S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family.
SPRY1 protein networkhttps://string-db.org/network/9606.ENSP00000481675Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
PRAMEF25 protein networkhttps://string-db.org/network/9606.ENSP00000481683PRAME family member 25; Belongs to the PRAME family.
FADS6 protein networkhttps://string-db.org/network/9606.ENSP00000481684Fatty acid desaturase 6.
SLC35E2B protein networkhttps://string-db.org/network/9606.ENSP00000481694Solute carrier family 35 member E2B; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily.
RSRC1 protein networkhttps://string-db.org/network/9606.ENSP00000481697Serine/Arginine-related protein 53; Has a role in alternative splicing and transcription regulation. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recogn [...]
SERPINI2 protein networkhttps://string-db.org/network/9606.ENSP00000481699Serpin family I member 2.
TBC1D2 protein networkhttps://string-db.org/network/9606.ENSP00000481721TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of ca [...]
ABCG4 protein networkhttps://string-db.org/network/9606.ENSP00000481728ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis.
MED29 protein networkhttps://string-db.org/network/9606.ENSP00000481733Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
AP5S1 protein networkhttps://string-db.org/network/9606.ENSP00000481750AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is required for efficient homologous recombinati [...]
CSDE1 protein networkhttps://string-db.org/network/9606.ENSP00000481762Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Im [...]
SAP25 protein networkhttps://string-db.org/network/9606.ENSP00000481773Histone deacetylase complex subunit SAP25; Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex.
MAPK8IP3 protein networkhttps://string-db.org/network/9606.ENSP00000481780C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...]
MFRP protein networkhttps://string-db.org/network/9606.ENSP00000481824Membrane frizzled-related protein; May play a role in eye development.
HPCAL4 protein networkhttps://string-db.org/network/9606.ENSP00000481834Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation.
CD24 protein networkhttps://string-db.org/network/9606.ENSP00000481841Signal transducer CD24; May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, an [...]
SAP18 protein networkhttps://string-db.org/network/9606.ENSP00000481842Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can [...]
KCNN3 protein networkhttps://string-db.org/network/9606.ENSP00000481848Small conductance calcium-activated potassium channel protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...]
JADE3 protein networkhttps://string-db.org/network/9606.ENSP00000481850Protein Jade-3; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetyl [...]
FAM13C protein networkhttps://string-db.org/network/9606.ENSP00000481854Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family.
PAN2 protein networkhttps://string-db.org/network/9606.ENSP00000481859PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miR [...]
ARHGAP23 protein networkhttps://string-db.org/network/9606.ENSP00000481862Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
PGRMC2 protein networkhttps://string-db.org/network/9606.ENSP00000481886Membrane-associated progesterone receptor component 2; Receptor for steroids.
CNOT6 protein networkhttps://string-db.org/network/9606.ENSP00000481893CCR4-NOT transcription complex subunit 6; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linke [...]
CHST12 protein networkhttps://string-db.org/network/9606.ENSP00000481912Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfat [...]
SEZ6L2 protein networkhttps://string-db.org/network/9606.ENSP00000481917Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family.
MED6 protein networkhttps://string-db.org/network/9606.ENSP00000481920Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...]
ARHGAP11B-2 protein networkhttps://string-db.org/network/9606.ENSP00000481934Rho GTPase activating protein 11B.
CEACAM20 protein networkhttps://string-db.org/network/9606.ENSP00000481937Carcinoembryonic antigen-related cell adhesion molecule 20; Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a [...]
CREB3L1 protein networkhttps://string-db.org/network/9606.ENSP00000481956Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. In th [...]
EPHB6 protein networkhttps://string-db.org/network/9606.ENSP00000481994Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negat [...]
NR4A3 protein networkhttps://string-db.org/network/9606.ENSP00000482027Nuclear receptor subfamily 4 group A member 3; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces ge [...]
ZNF2 protein networkhttps://string-db.org/network/9606.ENSP00000482030Zinc finger protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
IP6K1 protein networkhttps://string-db.org/network/9606.ENSP00000482032Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4; B [...]
LOC102723713 protein networkhttps://string-db.org/network/9606.ENSP00000482038TP53-target gene 3 protein.
PCGF2 protein networkhttps://string-db.org/network/9606.ENSP00000482063Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell prolifer [...]
PTGES3 protein networkhttps://string-db.org/network/9606.ENSP00000482075Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localiz [...]
PER3 protein networkhttps://string-db.org/network/9606.ENSP00000482093Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processe [...]
LOC102724159 protein networkhttps://string-db.org/network/9606.ENSP00000482107Uncharacterized protein.
IQCA1L protein networkhttps://string-db.org/network/9606.ENSP00000482119IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 like; Belongs to the AAA ATPase family.
SYNJ2BP-COX16 protein networkhttps://string-db.org/network/9606.ENSP00000482133SYNJ2BP-COX16 readthrough.
FAM156A protein networkhttps://string-db.org/network/9606.ENSP00000482142Family with sequence similarity 156 member A.
NEFL protein networkhttps://string-db.org/network/9606.ENSP00000482169Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
C11orf95 protein networkhttps://string-db.org/network/9606.ENSP00000482180Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95.
ZCCHC18 protein networkhttps://string-db.org/network/9606.ENSP00000482195Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family.
PIGW protein networkhttps://string-db.org/network/9606.ENSP00000482202Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol rin [...]
BCL2L12 protein networkhttps://string-db.org/network/9606.ENSP00000482218Bcl-2-like protein 12; BCL2 like 12; Belongs to the Bcl-2 family.
PLEKHA2 protein networkhttps://string-db.org/network/9606.ENSP00000482228Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins t [...]
CGA protein networkhttps://string-db.org/network/9606.ENSP00000482232Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/f [...]
CT45A7 protein networkhttps://string-db.org/network/9606.ENSP00000482241Cancer/testis antigen family 45 member A7.
DACH1 protein networkhttps://string-db.org/network/9606.ENSP00000482245Dachshund homolog 1; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in [...]
CCL4 protein networkhttps://string-db.org/network/9606.ENSP00000482259C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant MIP-1-beta induces a [...]
ENSP00000482263 protein networkhttps://string-db.org/network/9606.ENSP00000482263annotation not available
DGAT1 protein networkhttps://string-db.org/network/9606.ENSP00000482264Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it i [...]
CXorf49B protein networkhttps://string-db.org/network/9606.ENSP00000482270Chromosome X open reading frame 49B.
IFFO1 protein networkhttps://string-db.org/network/9606.ENSP00000482285Intermediate filament family orphan 1.
ZP4 protein networkhttps://string-db.org/network/9606.ENSP00000482304Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and [...]
TTC8 protein networkhttps://string-db.org/network/9606.ENSP00000482306Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is requ [...]
RECQL4 protein networkhttps://string-db.org/network/9606.ENSP00000482313ATP-dependent DNA helicase Q4; DNA-dependent ATPase. May modulate chromosome segregation. Belongs to the helicase family. RecQ subfamily.
ANKRD20A3 protein networkhttps://string-db.org/network/9606.ENSP00000482325Ankyrin repeat domain-containing protein 20A3.
MAP7 protein networkhttps://string-db.org/network/9606.ENSP00000482335Ensconsin; Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with micro [...]
TBC1D3C protein networkhttps://string-db.org/network/9606.ENSP00000482345TBC1 domain family member 3C.
PRSS57 protein networkhttps://string-db.org/network/9606.ENSP00000482358Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues ; Belongs to the peptidase S [...]
PRR36 protein networkhttps://string-db.org/network/9606.ENSP00000482374Proline-rich protein 36; Proline rich 36.
LRP5L protein networkhttps://string-db.org/network/9606.ENSP00000482378Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like.
IRX4 protein networkhttps://string-db.org/network/9606.ENSP00000482393Iroquois-class homeodomain protein IRX-4; Likely to be an important mediator of ventricular differentiation during cardiac development.
ALG9-2 protein networkhttps://string-db.org/network/9606.ENSP00000482396Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid- linked oligosaccharides; Belongs to the glycosyltransferase 22 family.
JRK protein networkhttps://string-db.org/network/9606.ENSP00000482410Jerky protein homolog; May bind DNA.
H2AC15 protein networkhttps://string-db.org/network/9606.ENSP00000482431H2A clustered histone 15.
ALG9 protein networkhttps://string-db.org/network/9606.ENSP00000482437ALG9 alpha-1,2-mannosyltransferase.
MED22 protein networkhttps://string-db.org/network/9606.ENSP00000482438Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
FXYD6-FXYD2 protein networkhttps://string-db.org/network/9606.ENSP00000482442FXYD domain-containing ion transport regulator; FXYD6-FXYD2 readthrough; Belongs to the FXYD family.
PRXL2A protein networkhttps://string-db.org/network/9606.ENSP00000482445Peroxiredoxin-like 2A; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorpti [...]
PLCG2 protein networkhttps://string-db.org/network/9606.ENSP000004824571-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by acti [...]
FAM228B protein networkhttps://string-db.org/network/9606.ENSP00000482482Protein FAM228B; Family with sequence similarity 228 member B; Belongs to the FAM228 family.
RAVER1 protein networkhttps://string-db.org/network/9606.ENSP00000482486Ribonucleoprotein PTB-binding 1; Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually excl [...]
TYW1B protein networkhttps://string-db.org/network/9606.ENSP00000482502S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base [...]
NR2E3 protein networkhttps://string-db.org/network/9606.ENSP00000482504Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. [...]
LCN8 protein networkhttps://string-db.org/network/9606.ENSP00000482512Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis.
LOC102724770 protein networkhttps://string-db.org/network/9606.ENSP00000482514Protein DGCR6.
SPATS2L protein networkhttps://string-db.org/network/9606.ENSP00000482515SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family.
CDRT4 protein networkhttps://string-db.org/network/9606.ENSP00000482523CMT1A duplicated region transcript 4.
H2AC16 protein networkhttps://string-db.org/network/9606.ENSP00000482538H2A clustered histone 16.
ZNF658 protein networkhttps://string-db.org/network/9606.ENSP00000482540Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory [...]
NDUFA6 protein networkhttps://string-db.org/network/9606.ENSP00000482543NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved [...]
REC8 protein networkhttps://string-db.org/network/9606.ENSP00000482546Meiotic recombination protein REC8 homolog; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin duri [...]
PIP4K2B protein networkhttps://string-db.org/network/9606.ENSP00000482548Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate.
FAM170A protein networkhttps://string-db.org/network/9606.ENSP00000482552Protein FAM170A; Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE).
H2AB3 protein networkhttps://string-db.org/network/9606.ENSP00000482564H2A.B variant histone 3.
ORAI1 protein networkhttps://string-db.org/network/9606.ENSP00000482568Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and cha [...]
TWIST2 protein networkhttps://string-db.org/network/9606.ENSP00000482581Twist-related protein 2; Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of [...]
METTL23 protein networkhttps://string-db.org/network/9606.ENSP00000482599Methyltransferase-like protein 23; Probable methyltransferase.
GCNT7 protein networkhttps://string-db.org/network/9606.ENSP00000482600Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; Glycosyltransferase.
HSH2D protein networkhttps://string-db.org/network/9606.ENSP00000482604Hematopoietic SH2 domain-containing protein; May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosi [...]
ZNF322 protein networkhttps://string-db.org/network/9606.ENSP00000482607Zinc finger protein 322; Transcriptional activator. Important for maintenance of pluripotency in embryonic stem cells (By similarity). Binds directly to the POU5F1 distal enhancer and the NANOG p [...]
PEX12 protein networkhttps://string-db.org/network/9606.ENSP00000482609Peroxisome assembly protein 12; Required for protein import into peroxisomes.
HMGN3 protein networkhttps://string-db.org/network/9606.ENSP00000482613High mobility group nucleosome-binding domain-containing protein 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA [...]
RAB11FIP4 protein networkhttps://string-db.org/network/9606.ENSP00000482620Rab11 family-interacting protein 4; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'addre [...]
TBC1D3H protein networkhttps://string-db.org/network/9606.ENSP00000482630TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
ZNF501 protein networkhttps://string-db.org/network/9606.ENSP00000482632Zinc finger protein 501; May be involved in transcriptional regulation. Essential for Golgi structural integrity.
MGST2 protein networkhttps://string-db.org/network/9606.ENSP00000482639Microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathion [...]
ARHGEF18 protein networkhttps://string-db.org/network/9606.ENSP00000482647Rho/Rac guanine nucleotide exchange factor 18.
MAP3K14 protein networkhttps://string-db.org/network/9606.ENSP00000482657Mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promo [...]
H2BC3 protein networkhttps://string-db.org/network/9606.ENSP00000482674Histone H2B type 1-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
IGKV1D-33 protein networkhttps://string-db.org/network/9606.ENSP00000482678Immunoglobulin kappa variable 1D-33.
DHRS11 protein networkhttps://string-db.org/network/9606.ENSP00000482704Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and t [...]
ALG1L protein networkhttps://string-db.org/network/9606.ENSP00000482705Putative glycosyltransferase ALG1-like; Putative glycosyltransferase.
PTPN9 protein networkhttps://string-db.org/network/9606.ENSP00000482732Tyrosine-protein phosphatase non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. Belongs to the [...]
TPSB2 protein networkhttps://string-db.org/network/9606.ENSP00000482743Tryptase beta 2; Belongs to the peptidase S1 family.
ZNF227 protein networkhttps://string-db.org/network/9606.ENSP00000482749Zinc finger protein 227; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
C9orf72 protein networkhttps://string-db.org/network/9606.ENSP00000482753Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 [...]
PCSK6 protein networkhttps://string-db.org/network/9606.ENSP00000482760Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...]
IDH3B protein networkhttps://string-db.org/network/9606.ENSP00000482773Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitr [...]
FTCDNL1 protein networkhttps://string-db.org/network/9606.ENSP00000482786Formiminotransferase cyclodeaminase N-terminal like.
MILR1 protein networkhttps://string-db.org/network/9606.ENSP00000482801Allergin-1; Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate [...]
EPB41L4A protein networkhttps://string-db.org/network/9606.ENSP00000482810Erythrocyte membrane protein band 4.1 like 4A.
CRYAA2 protein networkhttps://string-db.org/network/9606.ENSP00000482816Crystallin alpha A2.
ZNF343 protein networkhttps://string-db.org/network/9606.ENSP00000482819Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
NAPB protein networkhttps://string-db.org/network/9606.ENSP00000482826Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
SIK1B protein networkhttps://string-db.org/network/9606.ENSP00000482829Probable serine/threonine-protein kinase SIK1B; Probable serine/threonine-protein kinase. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.
CRABP2 protein networkhttps://string-db.org/network/9606.ENSP00000482841Cellular retinoic acid-binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
DOC2A protein networkhttps://string-db.org/network/9606.ENSP00000482870Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium depende [...]
PAMR1 protein networkhttps://string-db.org/network/9606.ENSP00000482899Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle. Belongs to the peptidase S1 family.
DTD1-2 protein networkhttps://string-db.org/network/9606.ENSP00000482916D-aminoacyl-tRNA deacylase 1; Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes.
DOC2B protein networkhttps://string-db.org/network/9606.ENSP00000482950Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and [...]
PRLR protein networkhttps://string-db.org/network/9606.ENSP00000482954Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC [...]
ALMS1 protein networkhttps://string-db.org/network/9606.ENSP00000482968Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for p [...]
NOP16 protein networkhttps://string-db.org/network/9606.ENSP00000483001NOP16 nucleolar protein; Belongs to the NOP16 family.
TRIM52 protein networkhttps://string-db.org/network/9606.ENSP00000483005E3 ubiquitin-protein ligase TRIM52; E3 ubiquitin-protein ligase. Positively regulates the NF-kappa-B signaling pathway.
ABO protein networkhttps://string-db.org/network/9606.ENSP00000483018Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form; This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: [...]
SLC2A11 protein networkhttps://string-db.org/network/9606.ENSP00000483038Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter.
NR2C2 protein networkhttps://string-db.org/network/9606.ENSP00000483059Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways suc [...]
POTEB3 protein networkhttps://string-db.org/network/9606.ENSP00000483103POTE ankyrin domain family member B3.
TAC3 protein networkhttps://string-db.org/network/9606.ENSP00000483110Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscle [...]
ACD protein networkhttps://string-db.org/network/9606.ENSP00000483117Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of d [...]
PADI6 protein networkhttps://string-db.org/network/9606.ENSP00000483125Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo.
FAM71D protein networkhttps://string-db.org/network/9606.ENSP00000483154Protein FAM71D; Family with sequence similarity 71 member D.
AP2B1 protein networkhttps://string-db.org/network/9606.ENSP00000483185AP-2 complex subunit beta; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways [...]
PPP4R3B protein networkhttps://string-db.org/network/9606.ENSP00000483228Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule org [...]
DCAF7 protein networkhttps://string-db.org/network/9606.ENSP00000483236DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The acti [...]
OR4M2 protein networkhttps://string-db.org/network/9606.ENSP00000483239Olfactory receptor 4M2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMEM106A protein networkhttps://string-db.org/network/9606.ENSP00000483246Transmembrane protein 106A; Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, upregulates the [...]
HNRNPDL protein networkhttps://string-db.org/network/9606.ENSP00000483254Heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity [...]
TMEM222 protein networkhttps://string-db.org/network/9606.ENSP00000483276Transmembrane protein 222.
MAFIP-2 protein networkhttps://string-db.org/network/9606.ENSP00000483280MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency. Belongs to the tektin family.
H3C11 protein networkhttps://string-db.org/network/9606.ENSP00000483283H3 clustered histone 11.
OR1N2 protein networkhttps://string-db.org/network/9606.ENSP00000483293Olfactory receptor 1N2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ACACA protein networkhttps://string-db.org/network/9606.ENSP00000483300Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps r [...]
WDR38 protein networkhttps://string-db.org/network/9606.ENSP00000483312WD repeat domain 38.
WASF2 protein networkhttps://string-db.org/network/9606.ENSP00000483313Wiskott-Aldrich syndrome protein family member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...]
POLR2J3 protein networkhttps://string-db.org/network/9606.ENSP00000483328DNA-directed RNA polymerase II subunit RPB11-b2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of R [...]
CCL4L2 protein networkhttps://string-db.org/network/9606.ENSP00000483330C-C motif chemokine ligand 4 like 2.
HDGFL2 protein networkhttps://string-db.org/network/9606.ENSP00000483345Hepatoma-derived growth factor-related protein 2; Involved in cellular growth control, through the regulation of cyclin D1 expression; Belongs to the HDGF family.
RIBC2 protein networkhttps://string-db.org/network/9606.ENSP00000483356RIB43A domain with coiled-coils 2.
TCTN3 protein networkhttps://string-db.org/network/9606.ENSP00000483364Tectonic-3; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regula [...]
GALE protein networkhttps://string-db.org/network/9606.ENSP00000483375UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine t [...]
RIMBP3 protein networkhttps://string-db.org/network/9606.ENSP00000483386RIMS-binding protein 3A; Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development; Belongs to [...]
FSBP protein networkhttps://string-db.org/network/9606.ENSP00000483397Fibrinogen silencer binding protein.
GHR protein networkhttps://string-db.org/network/9606.ENSP00000483403Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). Iso [...]
RBM26 protein networkhttps://string-db.org/network/9606.ENSP00000483408RNA binding motif protein 26.
ENSP00000483415 protein networkhttps://string-db.org/network/9606.ENSP00000483415annotation not available
MARK1 protein networkhttps://string-db.org/network/9606.ENSP00000483424Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microt [...]
IFI27 protein networkhttps://string-db.org/network/9606.ENSP00000483430Interferon alpha-inducible protein 27, mitochondrial; Probable adapter protein involved in different biological processes. Part of the signaling pathways that lead to apoptosis. Involved in type- [...]
SYNRG protein networkhttps://string-db.org/network/9606.ENSP00000483453Synergin gamma; May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins.
SBK3 protein networkhttps://string-db.org/network/9606.ENSP00000483467Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily.
GPR179 protein networkhttps://string-db.org/network/9606.ENSP00000483469Probable G-protein coupled receptor 179; Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Belongs to the G-protein coupled recepto [...]
NSA2 protein networkhttps://string-db.org/network/9606.ENSP00000483484Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
ARFRP1 protein networkhttps://string-db.org/network/9606.ENSP00000483486ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipid [...]
NTMT1 protein networkhttps://string-db.org/network/9606.ENSP00000483489N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed; Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Al [...]
R3HCC1L protein networkhttps://string-db.org/network/9606.ENSP00000483494Coiled-coil domain-containing protein R3HCC1L; R3H domain and coiled-coil containing 1 like.
DDX27 protein networkhttps://string-db.org/network/9606.ENSP00000483495Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 4 [...]
USP17L15 protein networkhttps://string-db.org/network/9606.ENSP00000483519Ubiquitin carboxyl-terminal hydrolase 17-like protein 15; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...]
LEPROT protein networkhttps://string-db.org/network/9606.ENSP00000483521Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor [...]
NOL4L protein networkhttps://string-db.org/network/9606.ENSP00000483523Nucleolar protein 4 like.
C11orf65 protein networkhttps://string-db.org/network/9606.ENSP00000483537Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65.
MID1IP1 protein networkhttps://string-db.org/network/9606.ENSP00000483547Mid1-interacting protein 1; Plays a role in the regulation of lipogenesis in liver. Up- regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diac [...]
RDM1 protein networkhttps://string-db.org/network/9606.ENSP00000483549RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA.
FURIN protein networkhttps://string-db.org/network/9606.ENSP00000483552Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation [...]
SALL2 protein networkhttps://string-db.org/network/9606.ENSP00000483562Sal-like protein 2; Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure.
IGKV2D-29 protein networkhttps://string-db.org/network/9606.ENSP00000483567Immunoglobulin kappa variable 2D-29; V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition. Immunoglobulins, also known as antibodies, are me [...]
BTK protein networkhttps://string-db.org/network/9606.ENSP00000483570Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) trigge [...]
IGKV2-40 protein networkhttps://string-db.org/network/9606.ENSP00000483585Immunoglobulin kappa variable 2-40.
SPON2 protein networkhttps://string-db.org/network/9606.ENSP00000483599Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage [...]
CT45A2 protein networkhttps://string-db.org/network/9606.ENSP00000483619Cancer/testis antigen family 45 member A2.
CABYR protein networkhttps://string-db.org/network/9606.ENSP00000483621Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 [...]
CLECL1 protein networkhttps://string-db.org/network/9606.ENSP00000483624C-type lectin-like domain family 1; May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role [...]
USP27X protein networkhttps://string-db.org/network/9606.ENSP00000483631Ubiquitin carboxyl-terminal hydrolase 27; Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK- degradation signal. By acting [...]
CT45A9 protein networkhttps://string-db.org/network/9606.ENSP00000483637Cancer/testis antigen family 45 member A9.
MYH7B protein networkhttps://string-db.org/network/9606.ENSP00000483640Myosin-7B; Involved in muscle contraction.
CHD1 protein networkhttps://string-db.org/network/9606.ENSP00000483667Chromodomain-helicase-DNA-binding protein 1; ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) [...]
GOLGA6L22 protein networkhttps://string-db.org/network/9606.ENSP00000483673Golgin subfamily A member 6-like protein 22; Golgin A6 family like 22; Belongs to the GOLGA6 family.
PSMB3 protein networkhttps://string-db.org/network/9606.ENSP00000483688Proteasome subunit beta type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...]
KLRF1 protein networkhttps://string-db.org/network/9606.ENSP00000483713Killer cell lectin-like receptor subfamily F member 1; Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.
ZNF107 protein networkhttps://string-db.org/network/9606.ENSP00000483720Zinc finger protein 107.
ADCYAP1R1 protein networkhttps://string-db.org/network/9606.ENSP00000483721Pituitary adenylate cyclase-activating polypeptide type I receptor; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl c [...]
DAOA protein networkhttps://string-db.org/network/9606.ENSP00000483757D-amino acid oxidase activator; Seems to activate D-amino acid oxidase.
TRIM64 protein networkhttps://string-db.org/network/9606.ENSP00000483764Tripartite motif containing 64; Belongs to the TRIM/RBCC family.
CISD3 protein networkhttps://string-db.org/network/9606.ENSP00000483781CDGSH iron-sulfur domain-containing protein 3, mitochondrial; Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maint [...]
HPCAL1 protein networkhttps://string-db.org/network/9606.ENSP00000483786Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family.
GAGE13 protein networkhttps://string-db.org/network/9606.ENSP00000483811G antigen 13.
NPRL3 protein networkhttps://string-db.org/network/9606.ENSP00000483814GATOR complex protein NPRL3; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrol [...]
IKBKG protein networkhttps://string-db.org/network/9606.ENSP00000483825NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and u [...]
H2AC4 protein networkhttps://string-db.org/network/9606.ENSP00000483842H2A clustered histone 4.
TSPAN33 protein networkhttps://string-db.org/network/9606.ENSP00000483872Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficki [...]
XKR5 protein networkhttps://string-db.org/network/9606.ENSP00000483879XK-related protein 5; XK related 5.
NDUFB1 protein networkhttps://string-db.org/network/9606.ENSP00000483888NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved i [...]
LYZL6 protein networkhttps://string-db.org/network/9606.ENSP00000483897Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus [...]
H2BC15 protein networkhttps://string-db.org/network/9606.ENSP00000483903Histone H2B type 1-N; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...]
SSBP2 protein networkhttps://string-db.org/network/9606.ENSP00000483921Single stranded DNA binding protein 2.
FAM200B protein networkhttps://string-db.org/network/9606.ENSP00000483930Protein FAM200B; Family with sequence similarity 200 member B; Belongs to the FAM200 family.
SYTL3 protein networkhttps://string-db.org/network/9606.ENSP00000483936Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).
PHF19 protein networkhttps://string-db.org/network/9606.ENSP00000483946PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an acti [...]
ELOA3 protein networkhttps://string-db.org/network/9606.ENSP00000483981Elongin-A3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit [...]
CSNK2B-2 protein networkhttps://string-db.org/network/9606.ENSP00000483989Chimera CSNK2B-LY6G5B splicing isoform 991.
ZCCHC3 protein networkhttps://string-db.org/network/9606.ENSP00000484056Zinc finger CCHC domain-containing protein 3; Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting reco [...]
PACSIN1 protein networkhttps://string-db.org/network/9606.ENSP00000484060Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule sta [...]
CCL15 protein networkhttps://string-db.org/network/9606.ENSP00000484078C-C motif chemokine 15; Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15 [...]
H3C7 protein networkhttps://string-db.org/network/9606.ENSP00000484095H3 clustered histone 7.
PRIM2 protein networkhttps://string-db.org/network/9606.ENSP00000484105DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an e [...]
ARFIP2 protein networkhttps://string-db.org/network/9606.ENSP00000484121Arfaptin-2; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which [...]
COLCA2 protein networkhttps://string-db.org/network/9606.ENSP00000484135Colorectal cancer associated 2.
MFSD1 protein networkhttps://string-db.org/network/9606.ENSP00000484175Major facilitator superfamily domain containing 1.
CLEC18A protein networkhttps://string-db.org/network/9606.ENSP00000484176C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans.
TBC1D3K protein networkhttps://string-db.org/network/9606.ENSP00000484181TBC1 domain family member 3K; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity).
ATRAID protein networkhttps://string-db.org/network/9606.ENSP00000484228All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 e [...]
PRAMEF7 protein networkhttps://string-db.org/network/9606.ENSP00000484237PRAME family member 7; Belongs to the PRAME family.
TSGA10IP protein networkhttps://string-db.org/network/9606.ENSP00000484252Testis specific 10 interacting protein.
H2AB1 protein networkhttps://string-db.org/network/9606.ENSP00000484261Histone H2A-Bbd type 1; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact D [...]
TMEM114 protein networkhttps://string-db.org/network/9606.ENSP00000484263Transmembrane protein 114.
LIG4 protein networkhttps://string-db.org/network/9606.ENSP00000484288DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non- homologous end joining (NHEJ) required for double- [...]
NEB protein networkhttps://string-db.org/network/9606.ENSP00000484342Nebulin; This giant muscle protein may be involved in maintaining the structural integrity of sarcomeres and the membrane system associated with the myofibrils. Binds and stabilize F-actin.
SERPINB6 protein networkhttps://string-db.org/network/9606.ENSP00000484343Serpin B6; May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May pl [...]
TARM1 protein networkhttps://string-db.org/network/9606.ENSP00000484383T-cell-interacting, activating receptor on myeloid cells protein 1; May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by [...]
DAPK2 protein networkhttps://string-db.org/network/9606.ENSP00000484390Death-associated protein kinase 2; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regu [...]
SMTN protein networkhttps://string-db.org/network/9606.ENSP00000484398Smoothelin; Structural protein of the cytoskeleton.
TPTE protein networkhttps://string-db.org/network/9606.ENSP00000484403Putative tyrosine-protein phosphatase TPTE; Could be involved in signal transduction.
HOXA3 protein networkhttps://string-db.org/network/9606.ENSP00000484411Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...]
CD48 protein networkhttps://string-db.org/network/9606.ENSP00000484431CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
NEK3 protein networkhttps://string-db.org/network/9606.ENSP00000484443Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contribute [...]
EPPK1 protein networkhttps://string-db.org/network/9606.ENSP00000484472Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is ass [...]
IFNA5 protein networkhttps://string-db.org/network/9606.ENSP00000484479Interferon alpha-5; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...]
RBIS protein networkhttps://string-db.org/network/9606.ENSP00000484492Ribosomal biogenesis factor; Trans-acting factor in ribosome biogenesis required for efficient 40S and 60S subunit production.
OVCH2 protein networkhttps://string-db.org/network/9606.ENSP00000484497Ovochymase-2; Ovochymase 2.
CTDP1 protein networkhttps://string-db.org/network/9606.ENSP00000484525RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase I [...]
GJA5 protein networkhttps://string-db.org/network/9606.ENSP00000484552Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
PPP1R2 protein networkhttps://string-db.org/network/9606.ENSP00000484580Protein phosphatase inhibitor 2; Inhibitor of protein-phosphatase 1.
CT45A10 protein networkhttps://string-db.org/network/9606.ENSP00000484601Cancer/testis antigen family 45 member A10.
CRISP2 protein networkhttps://string-db.org/network/9606.ENSP00000484609Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
OBP2B protein networkhttps://string-db.org/network/9606.ENSP00000484615Odorant-binding protein 2b; Probably binds and transports small hydrophobic volatile molecules; Belongs to the calycin superfamily. Lipocalin family.
APELA protein networkhttps://string-db.org/network/9606.ENSP00000484618Apelin receptor early endogenous ligand; Endogenous ligand for the apelin receptor (APLNR). Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis dur [...]
TCP10 protein networkhttps://string-db.org/network/9606.ENSP00000484621T-complex protein 10A homolog.
LRRC6 protein networkhttps://string-db.org/network/9606.ENSP00000484634Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility. Belongs to the tilB family.
H3C8 protein networkhttps://string-db.org/network/9606.ENSP00000484638H3 clustered histone 8.
B3GNT6 protein networkhttps://string-db.org/network/9606.ENSP00000484640Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important [...]
CHAC1 protein networkhttps://string-db.org/network/9606.ENSP00000484644Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma [...]
H3C3 protein networkhttps://string-db.org/network/9606.ENSP00000484658H3 clustered histone 3.
GAGE1 protein networkhttps://string-db.org/network/9606.ENSP00000484668G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family.
CPSF1 protein networkhttps://string-db.org/network/9606.ENSP00000484669Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, reco [...]
ZNHIT3 protein networkhttps://string-db.org/network/9606.ENSP00000484687Zinc finger HIT-type containing 3.
IFITM2 protein networkhttps://string-db.org/network/9606.ENSP00000484689Interferon-induced transmembrane protein 2; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral f [...]
EPOP protein networkhttps://string-db.org/network/9606.ENSP00000484710Elongin BC and Polycomb repressive complex 2-associated protein; Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine- [...]
WASHC4 protein networkhttps://string-db.org/network/9606.ENSP00000484713WASH complex subunit 4; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...]
SRCIN1 protein networkhttps://string-db.org/network/9606.ENSP00000484715SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Reg [...]
CASTOR2 protein networkhttps://string-db.org/network/9606.ENSP00000484732Cytosolic arginine sensor for mTORC1 subunit 2; Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, dir [...]
TMEM120A protein networkhttps://string-db.org/network/9606.ENSP00000484736Transmembrane protein 120A; Necessary for efficient adipogenesis. Belongs to the TMEM120 family.
H4C5 protein networkhttps://string-db.org/network/9606.ENSP00000484789H4 clustered histone 5.
FOXP1 protein networkhttps://string-db.org/network/9606.ENSP00000484803Forkhead box P1.
ARMC9 protein networkhttps://string-db.org/network/9606.ENSP00000484804LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh)signaling (By similarity). Involved in ciliogenesis (By similarity). May participate in the trafficking and/or r [...]
SPATA31A7 protein networkhttps://string-db.org/network/9606.ENSP00000484807Spermatogenesis-associated protein 31A7; May play a role in spermatogenesis; Belongs to the SPATA31 family.
ZNF274 protein networkhttps://string-db.org/network/9606.ENSP00000484810Neurotrophin receptor-interacting factor homolog; Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such a [...]
MUC1 protein networkhttps://string-db.org/network/9606.ENSP00000484824Mucin-1 subunit alpha; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacteri [...]
H3C2 protein networkhttps://string-db.org/network/9606.ENSP00000484841H3 clustered histone 2.
ZNF283 protein networkhttps://string-db.org/network/9606.ENSP00000484852Zinc finger protein 283; May be involved in transcriptional regulation.
EXOC5 protein networkhttps://string-db.org/network/9606.ENSP00000484855Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
ADAM29 protein networkhttps://string-db.org/network/9606.ENSP00000484862Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
FOXD4L6 protein networkhttps://string-db.org/network/9606.ENSP00000484875Forkhead box D4 like 6.
PIGBOS1 protein networkhttps://string-db.org/network/9606.ENSP00000484893Protein PIGBOS1; Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen.
MRPL45 protein networkhttps://string-db.org/network/9606.ENSP00000484903Mitochondrial ribosomal protein L45.
CDH4 protein networkhttps://string-db.org/network/9606.ENSP00000484928Cadherin-4; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...]
TRDV1 protein networkhttps://string-db.org/network/9606.ENSP00000484940T cell receptor delta variable 1; V region of the variable domain of T cell receptor (TR) delta chain that participates in the antigen recognition. Gamma-delta TRs recognize a variety of self and [...]
PRAC2 protein networkhttps://string-db.org/network/9606.ENSP00000484945PRAC2 small nuclear protein.
PSMC6 protein networkhttps://string-db.org/network/9606.ENSP0000048499826S proteasome regulatory subunit 10B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role i [...]
CIITA protein networkhttps://string-db.org/network/9606.ENSP00000485010MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected [...]
U2AF1L5 protein networkhttps://string-db.org/network/9606.ENSP00000485022U2 small nuclear RNA auxiliary factor 1 like 5.
MUC13 protein networkhttps://string-db.org/network/9606.ENSP00000485028Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
DEFB133 protein networkhttps://string-db.org/network/9606.ENSP00000485031Beta-defensin 133; Has antibacterial activity; Belongs to the beta-defensin family.
DOCK1 protein networkhttps://string-db.org/network/9606.ENSP00000485033Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epith [...]
TRIM49D2 protein networkhttps://string-db.org/network/9606.ENSP00000485097Tripartite motif containing 49D2.
UBTFL1 protein networkhttps://string-db.org/network/9606.ENSP00000485108Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.
OR12D2 protein networkhttps://string-db.org/network/9606.ENSP00000485112Olfactory receptor 12D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PSG7 protein networkhttps://string-db.org/network/9606.ENSP00000485117Pregnancy specific beta-1-glycoprotein 7.
SPATA31A3 protein networkhttps://string-db.org/network/9606.ENSP00000485118Spermatogenesis-associated protein 31A3; May play a role in spermatogenesis; Belongs to the SPATA31 family.
LOC102723996 protein networkhttps://string-db.org/network/9606.ENSP00000485129ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and diffe [...]
OR1S1 protein networkhttps://string-db.org/network/9606.ENSP00000485156Olfactory receptor 1S1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PPIAL4A protein networkhttps://string-db.org/network/9606.ENSP00000485206Peptidyl-prolyl cis-trans isomerase A-like 4A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...]
MTLN protein networkhttps://string-db.org/network/9606.ENSP00000485216Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability (By similarity). Increases mitochondrial membrane potential and mitochondrial respiration rate awhile decreasing [...]
ZSCAN26 protein networkhttps://string-db.org/network/9606.ENSP00000485228Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation.
SPDYE6 protein networkhttps://string-db.org/network/9606.ENSP00000485230Speedy protein E6; speedy/RINGO cell cycle regulator family member E6; Belongs to the Speedy/Ringo family.
FER1L5 protein networkhttps://string-db.org/network/9606.ENSP00000485238Fer-1-like protein 5; Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
OR5AR1 protein networkhttps://string-db.org/network/9606.ENSP00000485240Olfactory receptor 5AR1; Odorant receptor.
USP17L4 protein networkhttps://string-db.org/network/9606.ENSP00000485243Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4; Ubiquitin specific peptidase 17 like family member 4.
PRAMEF9 protein networkhttps://string-db.org/network/9606.ENSP00000485258PRAME family member 9.
ENSP00000485259 protein networkhttps://string-db.org/network/9606.ENSP00000485259Uncharacterized protein.
SCARF2 protein networkhttps://string-db.org/network/9606.ENSP00000485276Scavenger receptor class F member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of a [...]
OR2L8 protein networkhttps://string-db.org/network/9606.ENSP00000485287Olfactory receptor 2L8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52R1 protein networkhttps://string-db.org/network/9606.ENSP00000485292Olfactory receptor 52R1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4C16 protein networkhttps://string-db.org/network/9606.ENSP00000485295Olfactory receptor 4C16; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
USP17L8 protein networkhttps://string-db.org/network/9606.ENSP00000485306Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8; Ubiquitin specific peptidase 17 like family member 8.
SMIM26 protein networkhttps://string-db.org/network/9606.ENSP00000485316Small integral membrane protein 26.
OR5L1 protein networkhttps://string-db.org/network/9606.ENSP00000485319Olfactory receptor 5L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
USP17L3 protein networkhttps://string-db.org/network/9606.ENSP00000485323Ubiquitin carboxyl-terminal hydrolase 17-like protein 3; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...]
OR5R1 protein networkhttps://string-db.org/network/9606.ENSP00000485324Olfactory receptor 5R1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
USP17L7 protein networkhttps://string-db.org/network/9606.ENSP00000485337Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7; Ubiquitin specific peptidase 17 like family member 7.
HMCN2 protein networkhttps://string-db.org/network/9606.ENSP00000485357Hemicentin-2; Hemicentin 2.
USP17L1 protein networkhttps://string-db.org/network/9606.ENSP00000485364Ubiquitin carboxyl-terminal hydrolase 17-like protein 1; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...]
FAM25C protein networkhttps://string-db.org/network/9606.ENSP00000485370Family with sequence similarity 25 member C.
TRIM39-RPP21 protein networkhttps://string-db.org/network/9606.ENSP00000485378Ribonuclease P protein subunit p21; TRIM39-RPP21 readthrough.
SPDYE5 protein networkhttps://string-db.org/network/9606.ENSP00000485398Speedy protein E5; speedy/RINGO cell cycle regulator family member E5; Belongs to the Speedy/Ringo family.
UQCRHL protein networkhttps://string-db.org/network/9606.ENSP00000485401Cytochrome b-c1 complex subunit 6-like, mitochondrial; May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondr [...]
OR51B2 protein networkhttps://string-db.org/network/9606.ENSP00000485407Olfactory receptor 51B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5D13 protein networkhttps://string-db.org/network/9606.ENSP00000485428Olfactory receptor 5D13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4X2 protein networkhttps://string-db.org/network/9606.ENSP00000485431Olfactory receptor 4X2; Odorant receptor.
ZNF727 protein networkhttps://string-db.org/network/9606.ENSP00000485448Putative zinc finger protein 727; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
HNRNPCL4 protein networkhttps://string-db.org/network/9606.ENSP00000485450Heterogeneous nuclear ribonucleoprotein C like 4.
TP53TG3E protein networkhttps://string-db.org/network/9606.ENSP00000485467TP53 target 3 family member E.
PRAMEF18 protein networkhttps://string-db.org/network/9606.ENSP00000485473PRAME family member 18; Belongs to the PRAME family.
CDHR1 protein networkhttps://string-db.org/network/9606.ENSP00000485478Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
OR2F1 protein networkhttps://string-db.org/network/9606.ENSP00000485483Olfactory receptor 2F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SMIM11B protein networkhttps://string-db.org/network/9606.ENSP00000485484Small integral membrane protein 11B; Belongs to the SMIM11 family.
QRFP protein networkhttps://string-db.org/network/9606.ENSP00000485512Orexigenic neuropeptide QRFP; Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by t [...]
WASHC2C protein networkhttps://string-db.org/network/9606.ENSP00000485513WASH complex subunit 2C; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recrui [...]
C8orf89 protein networkhttps://string-db.org/network/9606.ENSP00000485524Putative uncharacterized protein C8orf89; Chromosome 8 open reading frame 89.
ADSL protein networkhttps://string-db.org/network/9606.ENSP00000485525Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5- [...]
RASSF10 protein networkhttps://string-db.org/network/9606.ENSP00000485526Ras association domain-containing protein 10; Plays an important role in regulating embryonic neurogenesis.
CBSL protein networkhttps://string-db.org/network/9606.ENSP00000485527Cystathionine beta-synthase like.
OR52B4 protein networkhttps://string-db.org/network/9606.ENSP00000485530Olfactory receptor 52B4; Odorant receptor.
SERPINB11 protein networkhttps://string-db.org/network/9606.ENSP00000485532Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change.
MAGEA2 protein networkhttps://string-db.org/network/9606.ENSP00000485541MAGE family member A2.
ZNF735 protein networkhttps://string-db.org/network/9606.ENSP00000485547Putative zinc finger protein 735; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SAA2-SAA4 protein networkhttps://string-db.org/network/9606.ENSP00000485552SAA2-SAA4 readthrough.
OR1B1 protein networkhttps://string-db.org/network/9606.ENSP00000485577Olfactory receptor 1B1; Odorant receptor.
CERS1 protein networkhttps://string-db.org/network/9606.ENSP00000485582Ceramide synthase 1.
NXF2 protein networkhttps://string-db.org/network/9606.ENSP00000485586Nuclear RNA export factor 2.
OR10X1 protein networkhttps://string-db.org/network/9606.ENSP00000485609Olfactory receptor 10X1; Odorant receptor.
OR51G1 protein networkhttps://string-db.org/network/9606.ENSP00000485612Olfactory receptor 51G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZNF518A protein networkhttps://string-db.org/network/9606.ENSP00000485614Zinc finger protein 518A; May be involved in transcriptional regulation.
ENSP00000485615 protein networkhttps://string-db.org/network/9606.ENSP00000485615Novel protein, similar to trafficking protein particle complex 10 TRAPPC10.
WASHC1 protein networkhttps://string-db.org/network/9606.ENSP00000485627WASH complex subunit 1; Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key r [...]
SPATA31A5 protein networkhttps://string-db.org/network/9606.ENSP00000485628Spermatogenesis-associated protein 31A5; May play a role in spermatogenesis; Belongs to the SPATA31 family.
ENSP00000485630 protein networkhttps://string-db.org/network/9606.ENSP00000485630Utp12 domain-containing protein.
TP53TG3F protein networkhttps://string-db.org/network/9606.ENSP00000485635TP53 target 3 family member F.
PPIAL4F protein networkhttps://string-db.org/network/9606.ENSP00000485638Peptidylprolyl isomerase A like 4F.
PRAMEF26 protein networkhttps://string-db.org/network/9606.ENSP00000485656PRAME family member 26.
MUC5AC protein networkhttps://string-db.org/network/9606.ENSP00000485659Mucin-5AC; Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that [...]
OR8D2 protein networkhttps://string-db.org/network/9606.ENSP00000485661Olfactory receptor 8D2; Odorant receptor (Potential). May be involved in taste perception.
LINC02203-2 protein networkhttps://string-db.org/network/9606.ENSP00000485668Olfactory receptor.
MTRES1 protein networkhttps://string-db.org/network/9606.ENSP00000485698Mitochondrial transcription rescue factor 1; Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondria [...]
ZNF280B protein networkhttps://string-db.org/network/9606.ENSP00000485750Zinc finger protein 280B; May function as a transcription factor.
LOC112694756 protein networkhttps://string-db.org/network/9606.ENSP00000485952Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family.
TRPC4 protein networkhttps://string-db.org/network/9606.ENSP00000486109Short transient receptor potential channel 4; Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Pr [...]
SMIM7 protein networkhttps://string-db.org/network/9606.ENSP00000486146Small integral membrane protein 7.
SYT14 protein networkhttps://string-db.org/network/9606.ENSP00000486230Synaptotagmin-14; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Belongs to the synaptotagmin family.
RPS4Y2 protein networkhttps://string-db.org/network/9606.ENSP00000486252Ribosomal protein S4 Y-linked 2; Belongs to the eukaryotic ribosomal protein eS4 family.
FARP1 protein networkhttps://string-db.org/network/9606.ENSP00000486285FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disass [...]
SUGCT protein networkhttps://string-db.org/network/9606.ENSP00000486291Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferr [...]
PPIP5K2 protein networkhttps://string-db.org/network/9606.ENSP00000486357Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphos [...]
DBI protein networkhttps://string-db.org/network/9606.ENSP00000486361Acyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepa [...]
ZIM2 protein networkhttps://string-db.org/network/9606.ENSP00000486502Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CNOT9 protein networkhttps://string-db.org/network/9606.ENSP00000486540CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...]
UBAP1 protein networkhttps://string-db.org/network/9606.ENSP00000486574Ubiquitin-associated protein 1; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic [...]
ENSP00000486623 protein networkhttps://string-db.org/network/9606.ENSP00000486623Novel protein.
TREX1 protein networkhttps://string-db.org/network/9606.ENSP00000486676Three-prime repair exonuclease 1; Major cellular 3'-to-5' DNA exonuclease which digests single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intr [...]
TIGD2 protein networkhttps://string-db.org/network/9606.ENSP00000486687Tigger transposable element derived 2.
PPIL2 protein networkhttps://string-db.org/network/9606.ENSP00000486725RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin [...]
TCF7L2 protein networkhttps://string-db.org/network/9606.ENSP00000486891Transcription factor 7-like 2; Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of [...]
MICAL1 protein networkhttps://string-db.org/network/9606.ENSP00000486901[F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in [...]
COBLL1 protein networkhttps://string-db.org/network/9606.ENSP00000487041Cordon-bleu WH2 repeat protein like 1.
CCDC163 protein networkhttps://string-db.org/network/9606.ENSP00000487061Transmembrane protein CCDC163; Coiled-coil domain containing 163.
NANOGP8 protein networkhttps://string-db.org/network/9606.ENSP00000487073Homeobox protein NANOGP8; May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation; Belongs to the Nanog homeobox fami [...]
ENSP00000487094 protein networkhttps://string-db.org/network/9606.ENSP00000487094Novel protein, lncRNA-POLR3GL readthrough.
OXNAD1 protein networkhttps://string-db.org/network/9606.ENSP00000487136Oxidoreductase NAD-binding domain-containing protein 1; Oxidoreductase NAD binding domain containing 1.
VPS8 protein networkhttps://string-db.org/network/9606.ENSP00000487164Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the puta [...]
ZEB2 protein networkhttps://string-db.org/network/9606.ENSP00000487174Zinc finger E-box-binding homeobox 2; Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E-cadherin.
ZNF793 protein networkhttps://string-db.org/network/9606.ENSP00000487183Zinc finger protein 793; May be involved in transcriptional regulation.
FAM122B protein networkhttps://string-db.org/network/9606.ENSP00000487221Protein FAM122B; Family with sequence similarity 122B; Belongs to the FAM122 family.
THEMIS protein networkhttps://string-db.org/network/9606.ENSP00000487358Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lin [...]
HAVCR1 protein networkhttps://string-db.org/network/9606.ENSP00000487363Hepatitis A virus cellular receptor 1; May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidn [...]
HSPH1 protein networkhttps://string-db.org/network/9606.ENSP00000487365Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate pro [...]
SPTAN1 protein networkhttps://string-db.org/network/9606.ENSP00000487444Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent [...]
OVOL3 protein networkhttps://string-db.org/network/9606.ENSP00000487603Putative transcription factor ovo-like protein 3; May act as a transcription regulator; Belongs to the krueppel C2H2-type zinc-finger protein family.
PITPNB protein networkhttps://string-db.org/network/9606.ENSP00000487693Phosphatidylinositol transfer protein beta isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.
SMIM10L2B protein networkhttps://string-db.org/network/9606.ENSP00000487709Small integral membrane protein 10 like 2B.
ENSP00000487717 protein networkhttps://string-db.org/network/9606.ENSP00000487717Uncharacterized protein.
TUBA4B protein networkhttps://string-db.org/network/9606.ENSP00000487719Putative tubulin-like protein alpha-4B; Tubulin alpha 4b.
SPDYE16 protein networkhttps://string-db.org/network/9606.ENSP00000487772speedy/RINGO cell cycle regulator family member E16; Belongs to the Speedy/Ringo family.
KCNA2 protein networkhttps://string-db.org/network/9606.ENSP00000487785Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the centra [...]
TMEM132E protein networkhttps://string-db.org/network/9606.ENSP00000487800Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing. Belongs to the TMEM132 family.
LPIN3 protein networkhttps://string-db.org/network/9606.ENSP00000487971Phosphatidate phosphatase LPIN3; Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during [...]
TEX13C protein networkhttps://string-db.org/network/9606.ENSP00000488022Putative testis-expressed protein 13C; TEX13 family member C; Belongs to the TEX13 family.
SLC22A18AS protein networkhttps://string-db.org/network/9606.ENSP00000488024Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein; Solute carrier family 22 member 18 antisense.
SPATA31D3 protein networkhttps://string-db.org/network/9606.ENSP00000488117Spermatogenesis-associated protein 31D3; May play a role in spermatogenesis; Belongs to the SPATA31 family.
SPATA31D4 protein networkhttps://string-db.org/network/9606.ENSP00000488251Spermatogenesis-associated protein 31D4; May play a role in spermatogenesis; Belongs to the SPATA31 family.
MAGEB6B protein networkhttps://string-db.org/network/9606.ENSP00000488257MAGE family member B6B.
PNMA6F protein networkhttps://string-db.org/network/9606.ENSP00000488302Paraneoplastic antigen Ma6F; PNMA family member 6F.
NCBP2AS2 protein networkhttps://string-db.org/network/9606.ENSP00000488305Protein NCBP2AS2; NCBP2 antisense 2.
BECN2 protein networkhttps://string-db.org/network/9606.ENSP00000488361Beclin-2; Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of [...]
PNMA6E protein networkhttps://string-db.org/network/9606.ENSP00000488404Paraneoplastic antigen Ma6E; PNMA family member 6E.
CELF2 protein networkhttps://string-db.org/network/9606.ENSP00000488422CUGBP Elav-like family member 2; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability [...]
PRSS2 protein networkhttps://string-db.org/network/9606.ENSP00000488437Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family.
PLIN4 protein networkhttps://string-db.org/network/9606.ENSP00000488481Perilipin-4; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity); Belongs to the perilipin fa [...]
NPHP3-ACAD11 protein networkhttps://string-db.org/network/9606.ENSP00000488520NPHP3-ACAD11 readthrough.
LINC00514 protein networkhttps://string-db.org/network/9606.ENSP00000488558Long intergenic non-protein coding RNA 514.
MEIKIN protein networkhttps://string-db.org/network/9606.ENSP00000488568Meiosis-specific kinetochore protein; Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeri [...]
TENT4A protein networkhttps://string-db.org/network/9606.ENSP00000488642Terminal nucleotidyltransferase 4A; Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail lead [...]
NHSL2 protein networkhttps://string-db.org/network/9606.ENSP00000488668NHS-like protein 2; NHS like 2; Belongs to the NHS family.
TEX13D protein networkhttps://string-db.org/network/9606.ENSP00000488696Testis-expressed protein 13D; TEX13 family member D; Belongs to the TEX13 family.
MRLN protein networkhttps://string-db.org/network/9606.ENSP00000488748Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal mus [...]
ENSP00000488802 protein networkhttps://string-db.org/network/9606.ENSP00000488802Uncharacterized protein.
PON2 protein networkhttps://string-db.org/network/9606.ENSP00000488838Serum paraoxonase/arylesterase 2; Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Preve [...]
SMIM10L1 protein networkhttps://string-db.org/network/9606.ENSP00000488907Small integral membrane protein 10 like 1.
CRHR1-2 protein networkhttps://string-db.org/network/9606.ENSP00000488912LINC02210-CRHR1 readthrough.
CCDC149 protein networkhttps://string-db.org/network/9606.ENSP00000488929Coiled-coil domain containing 149.
GLYATL1B protein networkhttps://string-db.org/network/9606.ENSP00000488958Putative glycine N-acyltransferase-like protein 1B; Putative acyltransferase which transfers an acyl group to the N-terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor. Belongs to th [...]
NLRP2B protein networkhttps://string-db.org/network/9606.ENSP00000488995NLR family pyrin domain-containing protein 2B; May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activ [...]
KLF18 protein networkhttps://string-db.org/network/9606.ENSP00000489024Kruppel like factor 18.
C1GALT1C1L protein networkhttps://string-db.org/network/9606.ENSP00000489061C1GALT1-specific chaperone 1-like protein; C1GALT1 specific chaperone 1 like.
SCYL2 protein networkhttps://string-db.org/network/9606.ENSP00000489123SCY1-like protein 2; Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to probable serine/threonine-protein kinase that phos [...]
ERVK3-1 protein networkhttps://string-db.org/network/9606.ENSP00000489180Endogenous retrovirus group K3 member 1.
BAG1 protein networkhttps://string-db.org/network/9606.ENSP00000489189BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...]
CSMD1 protein networkhttps://string-db.org/network/9606.ENSP00000489225CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas.
H4C8 protein networkhttps://string-db.org/network/9606.ENSP00000489236H4 clustered histone 8.
RYR3 protein networkhttps://string-db.org/network/9606.ENSP00000489262Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. M [...]
CENPVL1 protein networkhttps://string-db.org/network/9606.ENSP00000489273Centromere protein V like 1.
H3C6 protein networkhttps://string-db.org/network/9606.ENSP00000489282H3 clustered histone 6.
hCG_2039566 protein networkhttps://string-db.org/network/9606.ENSP00000489311Histone H2A; Belongs to the histone H2A family.
H2BC6 protein networkhttps://string-db.org/network/9606.ENSP00000489317H2B clustered histone 6.
C1orf232 protein networkhttps://string-db.org/network/9606.ENSP00000489320Uncharacterized protein C1orf232; Chromosome 1 open reading frame 230.
CENPVL2 protein networkhttps://string-db.org/network/9606.ENSP00000489328Centromere protein V like 2.
SHANK3 protein networkhttps://string-db.org/network/9606.ENSP00000489407SH3 and multiple ankyrin repeat domains protein 3; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse [...]
EXOC6B protein networkhttps://string-db.org/network/9606.ENSP00000489442Exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
CENPVL3 protein networkhttps://string-db.org/network/9606.ENSP00000489547Centromere protein V like 3.
NRXN3 protein networkhttps://string-db.org/network/9606.ENSP00000489551Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
NBDY protein networkhttps://string-db.org/network/9606.ENSP00000489583Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process.
PTPN11 protein networkhttps://string-db.org/network/9606.ENSP00000489597Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to [...]
SPTY2D1OS protein networkhttps://string-db.org/network/9606.ENSP00000489616Putative transmembrane protein SPTY2D1OS; SPTY2D1 opposite strand.
TUNAR protein networkhttps://string-db.org/network/9606.ENSP00000489624TCL1 upstream neural differentiation-associated RNA.
C11orf53 protein networkhttps://string-db.org/network/9606.ENSP00000489630Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53.
UMAD1 protein networkhttps://string-db.org/network/9606.ENSP00000489648UBAP1-MVB12-associated domain containing 1.
CNTNAP3C protein networkhttps://string-db.org/network/9606.ENSP00000489658Contactin associated protein family member 3C.
HSPA12A protein networkhttps://string-db.org/network/9606.ENSP00000489674Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization.
DNAH10 protein networkhttps://string-db.org/network/9606.ENSP00000489675Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...]
IQANK1 protein networkhttps://string-db.org/network/9606.ENSP00000489685IQ motif and ankyrin repeat containing 1.
GK3P protein networkhttps://string-db.org/network/9606.ENSP00000489687Glycerol kinase 3; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family.
CSNKA2IP protein networkhttps://string-db.org/network/9606.ENSP00000489704Casein kinase II subunit alpha'-interacting protein; May play a role in chromatin regulation of male germ cells.
TMEM191C protein networkhttps://string-db.org/network/9606.ENSP00000489706Transmembrane protein 191C.
LOC100505841 protein networkhttps://string-db.org/network/9606.ENSP00000489710Uncharacterized protein.
CCDC201 protein networkhttps://string-db.org/network/9606.ENSP00000489712Coiled-coil domain containing 201.
TSTD3 protein networkhttps://string-db.org/network/9606.ENSP00000489733Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3; Thiosulfate sulfurtransferase like domain containing 3.
C20orf204 protein networkhttps://string-db.org/network/9606.ENSP00000489747Uncharacterized protein C20orf204; Chromosome 20 open reading frame 204.
MPC1L protein networkhttps://string-db.org/network/9606.ENSP00000489748Mitochondrial pyruvate carrier 1 like.
PPP4R3C protein networkhttps://string-db.org/network/9606.ENSP00000489770Protein phosphatase 4 regulatory subunit 3C.
DLGAP2 protein networkhttps://string-db.org/network/9606.ENSP00000489774Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...]
TEX51 protein networkhttps://string-db.org/network/9606.ENSP00000489776Testis-expressed protein 51; Testis expressed 51.
SMIM29 protein networkhttps://string-db.org/network/9606.ENSP00000489784Small integral membrane protein 29.
POU5F2 protein networkhttps://string-db.org/network/9606.ENSP00000489796POU domain, class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are requi [...]
CXorf51A protein networkhttps://string-db.org/network/9606.ENSP00000489806Uncharacterized protein CXorf51A; Chromosome X open reading frame 51A.
SPRR5 protein networkhttps://string-db.org/network/9606.ENSP00000489807Small proline rich protein 5.
HSFX4 protein networkhttps://string-db.org/network/9606.ENSP00000489814Heat shock transcription factor family, X-linked member 4.
CACNA1A protein networkhttps://string-db.org/network/9606.ENSP00000489829Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of [...]
CTXND1 protein networkhttps://string-db.org/network/9606.ENSP00000489837Cortexin domain containing 1.
STRIT1 protein networkhttps://string-db.org/network/9606.ENSP00000489859Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF; Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting a [...]
TEX52 protein networkhttps://string-db.org/network/9606.ENSP00000489863Testis-expressed protein 52; Testis expressed 52.
TEX50 protein networkhttps://string-db.org/network/9606.ENSP00000489890Testis-expressed protein 50; Testis expressed 50.
CCDC196 protein networkhttps://string-db.org/network/9606.ENSP00000489898Putative coiled-coil domain-containing protein 196; Coiled-coil domain containing 196.
ENSP00000489910 protein networkhttps://string-db.org/network/9606.ENSP00000489910Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
SMIM28 protein networkhttps://string-db.org/network/9606.ENSP00000489939Small integral membrane protein 28.
TEX53 protein networkhttps://string-db.org/network/9606.ENSP00000489944Testis-expressed protein 53; Testis expressed 53.
CDCP2 protein networkhttps://string-db.org/network/9606.ENSP00000489959CUB domain containing protein 2.
C5orf58 protein networkhttps://string-db.org/network/9606.ENSP00000490013Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58.
C13orf46 protein networkhttps://string-db.org/network/9606.ENSP00000490032Uncharacterized protein C13orf46; Chromosome 13 open reading frame 46.
RAB6D protein networkhttps://string-db.org/network/9606.ENSP00000490038Ras-related protein Rab-6D; RAB6D, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family.
MYOCOS protein networkhttps://string-db.org/network/9606.ENSP00000490048Myocilin opposite strand.
ETDA protein networkhttps://string-db.org/network/9606.ENSP00000490055Embryonic testis differentiation homolog A.
ZNF883 protein networkhttps://string-db.org/network/9606.ENSP00000490059Zinc finger protein 883; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ATP6AP2 protein networkhttps://string-db.org/network/9606.ENSP00000490083Renin receptor C-terminal fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase [...]
CCDC197 protein networkhttps://string-db.org/network/9606.ENSP00000490086Uncharacterized protein CCDC197; Coiled-coil domain containing 197.
SMIM30 protein networkhttps://string-db.org/network/9606.ENSP00000490095Small integral membrane protein 30.
FAM240B protein networkhttps://string-db.org/network/9606.ENSP00000490097Protein FAM240B; Family with sequence similarity 240 member B; Belongs to the FAM240 family.
SCN2A protein networkhttps://string-db.org/network/9606.ENSP00000490107Sodium channel protein type 2 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
LCOR protein networkhttps://string-db.org/network/9606.ENSP00000490116Ligand-dependent corepressor; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcriptio [...]
RALGAPA1 protein networkhttps://string-db.org/network/9606.ENSP00000490119Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
PNMA8C protein networkhttps://string-db.org/network/9606.ENSP00000490139Paraneoplastic antigen-like protein 8C; PNMA family member 8C; Belongs to the PNMA family.
MYMX protein networkhttps://string-db.org/network/9606.ENSP00000490143Protein myomixer; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Involved in membrane fusion downstream of the lipi [...]
ENSP00000490163 protein networkhttps://string-db.org/network/9606.ENSP00000490163Protein kinase domain-containing protein.
NPY4R2 protein networkhttps://string-db.org/network/9606.ENSP00000490174Neuropeptide Y receptor type 4-2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [P [...]
SPAAR protein networkhttps://string-db.org/network/9606.ENSP00000490187Small regulatory polypeptide of amino acid response; [Isoform 2]: Negative regulator of amino acid sensing and mTORC1, a signaling complex promoting cell growth in response to growth factors, ene [...]
SMIM34B protein networkhttps://string-db.org/network/9606.ENSP00000490209Small integral membrane protein 34B.
C19orf85 protein networkhttps://string-db.org/network/9606.ENSP00000490220Uncharacterized protein C19orf85; Chromosome 19 open reading frame 85.
UBE2L5 protein networkhttps://string-db.org/network/9606.ENSP00000490225Ubiquitin-conjugating enzyme E2 L5; Catalyzes the covalent attachment of ubiquitin to other proteins.
C10orf143 protein networkhttps://string-db.org/network/9606.ENSP00000490233Uncharacterized protein C10orf143; Chromosome 10 open reading frame 143.
ZNF831 protein networkhttps://string-db.org/network/9606.ENSP00000490240Zinc finger protein 831.
C17orf113 protein networkhttps://string-db.org/network/9606.ENSP00000490245Transmembrane protein C17orf113; Chromosome 17 open reading frame 113.
TEX48 protein networkhttps://string-db.org/network/9606.ENSP00000490263Testis-expressed protein 48; Testis expressed 48.
LOC102723971 protein networkhttps://string-db.org/network/9606.ENSP00000490264Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.
SPEM3 protein networkhttps://string-db.org/network/9606.ENSP00000490274Uncharacterized protein SPEM3; SPEM family member 3.
SMIM27 protein networkhttps://string-db.org/network/9606.ENSP00000490275Small integral membrane protein 27.
ATP6V1FNB protein networkhttps://string-db.org/network/9606.ENSP00000490280Protein ATP6V1FNB; ATP6V1F neighbor.
CXorf51B protein networkhttps://string-db.org/network/9606.ENSP00000490294Chromosome X open reading frame 51B.
PPP1R2B protein networkhttps://string-db.org/network/9606.ENSP00000490297Protein phosphatase inhibitor 2 family member B; Inhibitor of protein-phosphatase 1.
GOLGA6L7 protein networkhttps://string-db.org/network/9606.ENSP00000490318Golgin subfamily A member 6-like protein 7; Golgin A6 family like 7; Belongs to the GOLGA6 family.
PPP1R2C protein networkhttps://string-db.org/network/9606.ENSP00000490336Protein phosphatase inhibitor 2 family member C; Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-asso [...]
CLEC19A protein networkhttps://string-db.org/network/9606.ENSP00000490375C-type lectin domain containing 19A.
TEPSIN protein networkhttps://string-db.org/network/9606.ENSP00000490393AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
REELD1 protein networkhttps://string-db.org/network/9606.ENSP00000490412Reelin domain-containing protein 1; Reeler domain containing 1.
FAM237B protein networkhttps://string-db.org/network/9606.ENSP00000490466Protein FAM237B; Family with sequence similarity 237 member B.
ARID1B protein networkhttps://string-db.org/network/9606.ENSP00000490491AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component [...]
C13orf42 protein networkhttps://string-db.org/network/9606.ENSP00000490517Uncharacterized protein C13orf42; Chromosome 13 open reading frame 42.
IQCM protein networkhttps://string-db.org/network/9606.ENSP00000490518IQ motif containing M.
ENSP00000490530 protein networkhttps://string-db.org/network/9606.ENSP00000490530Uncharacterized protein.
TTC34 protein networkhttps://string-db.org/network/9606.ENSP00000490537Tetratricopeptide repeat domain 34.
FAM240A protein networkhttps://string-db.org/network/9606.ENSP00000490556Protein FAM240A; Family with sequence similarity 240 member A; Belongs to the FAM240 family.
TMEM238L protein networkhttps://string-db.org/network/9606.ENSP00000490566Transmembrane protein 238 like.
TCAF2C protein networkhttps://string-db.org/network/9606.ENSP00000490573TRPM8 channel associated factor 2C.
ETDC protein networkhttps://string-db.org/network/9606.ENSP00000490576Embryonic testis differentiation homolog C.
C11orf97 protein networkhttps://string-db.org/network/9606.ENSP00000490577Uncharacterized protein C11orf97; Chromosome 11 open reading frame 97.
CCDC192 protein networkhttps://string-db.org/network/9606.ENSP00000490579Coiled-coil domain containing 192.
TINCR protein networkhttps://string-db.org/network/9606.ENSP00000490584TINCR ubiquitin domain containing.
C2orf92 protein networkhttps://string-db.org/network/9606.ENSP00000490587Uncharacterized protein C2orf92; Chromosome 2 open reading frame 92.
CCDC200 protein networkhttps://string-db.org/network/9606.ENSP00000490609Coiled-coil domain containing 200.
DCX protein networkhttps://string-db.org/network/9606.ENSP00000490614Neuronal migration protein doublecortin; Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by comp [...]
FAM240C protein networkhttps://string-db.org/network/9606.ENSP00000490626Protein FAM240C; Family with sequence similarity 240 member C; Belongs to the FAM240 family.
MDFIC2 protein networkhttps://string-db.org/network/9606.ENSP00000490638MyoD family inhibitor domain containing 2.
SMIM36 protein networkhttps://string-db.org/network/9606.ENSP00000490644Small integral membrane protein 36.
LITAFD protein networkhttps://string-db.org/network/9606.ENSP00000490685LITAF domain-containing protein; LITAF domain containing; Belongs to the CDIP1/LITAF family.
SMIM31 protein networkhttps://string-db.org/network/9606.ENSP00000490699Small integral membrane protein 31.
TMEM269 protein networkhttps://string-db.org/network/9606.ENSP00000490716Transmembrane protein 269.
TMEM272 protein networkhttps://string-db.org/network/9606.ENSP00000490718Transmembrane protein 272.
FBF1 protein networkhttps://string-db.org/network/9606.ENSP00000490726Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenes [...]
ABHD14A-ACY1 protein networkhttps://string-db.org/network/9606.ENSP00000490744ABHD14A-ACY1 readthrough.
MIEF1-2 protein networkhttps://string-db.org/network/9606.ENSP00000490747MIEF1 upstream open reading frame protein; Involved in the regulation of mitochondrial fission mediated by DNM1L. Positively regulates mitochondrial translation. May play a role in ribosome bioge [...]
EXOC1L protein networkhttps://string-db.org/network/9606.ENSP00000490760Exocyst complex component 1 like.
ING5 protein networkhttps://string-db.org/network/9606.ENSP00000490767Inhibitor of growth protein 5; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of hi [...]
SMIM33 protein networkhttps://string-db.org/network/9606.ENSP00000490796Small integral membrane protein 33.
FAM237A protein networkhttps://string-db.org/network/9606.ENSP00000490802Protein FAM237A; Family with sequence similarity 237 member A.
PLEKHG4B protein networkhttps://string-db.org/network/9606.ENSP00000490806Pleckstrin homology and RhoGEF domain containing G4B.
SLC35G4 protein networkhttps://string-db.org/network/9606.ENSP00000490812Solute carrier family 35 member G4.
SPACA6 protein networkhttps://string-db.org/network/9606.ENSP00000490829Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion.
ZNF654 protein networkhttps://string-db.org/network/9606.ENSP00000490842Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
PRRT1B protein networkhttps://string-db.org/network/9606.ENSP00000490857Proline rich transmembrane protein 1B.
CLEC20A protein networkhttps://string-db.org/network/9606.ENSP00000490899C-type lectin domain containing 20A.
BTBD8 protein networkhttps://string-db.org/network/9606.ENSP00000490913AP2-interacting clathrin-endocytosis protein; Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a [...]
BRD3OS protein networkhttps://string-db.org/network/9606.ENSP00000490916Putative uncharacterized protein BRD3OS; BRD3 opposite strand.
C14orf132 protein networkhttps://string-db.org/network/9606.ENSP00000490925Uncharacterized protein C14orf132; Chromosome 14 open reading frame 132.
IFIT2 protein networkhttps://string-db.org/network/9606.ENSP00000490935Interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'- [...]
ARHGEF9 protein networkhttps://string-db.org/network/9606.ENSP00000490940Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity).
LOC101059915 protein networkhttps://string-db.org/network/9606.ENSP00000490941Uncharacterized protein.
NYAP2 protein networkhttps://string-db.org/network/9606.ENSP00000490942Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesi [...]
ETDB protein networkhttps://string-db.org/network/9606.ENSP00000490943Embryonic testis differentiation homolog B.
ENSP00000490953 protein networkhttps://string-db.org/network/9606.ENSP00000490953Uncharacterized protein.
PVALEF protein networkhttps://string-db.org/network/9606.ENSP00000490956Parvalbumin-like EF-hand-containing protein; Parvalbumin like EF-hand containing; Belongs to the parvalbumin family.
MIA2 protein networkhttps://string-db.org/network/9606.ENSP00000491014Melanoma inhibitory activity protein 2; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membra [...]
ENSP00000491046 protein networkhttps://string-db.org/network/9606.ENSP00000491046Uncharacterized protein.
TTLL13P protein networkhttps://string-db.org/network/9606.ENSP00000491066Tubulin polyglutamylase TTLL13P; Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initi [...]
NECAP1 protein networkhttps://string-db.org/network/9606.ENSP00000491067Adaptin ear-binding coat-associated protein 1; Involved in endocytosis.
C17orf100 protein networkhttps://string-db.org/network/9606.ENSP00000491070Uncharacterized protein C17orf100; Chromosome 17 open reading frame 100.
ENSP00000491073 protein networkhttps://string-db.org/network/9606.ENSP00000491073Uncharacterized protein.
hCG_2014768 protein networkhttps://string-db.org/network/9606.ENSP00000491117HCG2014768, isoform CRA_a.
TAF11L8 protein networkhttps://string-db.org/network/9606.ENSP00000491174TATA-box-binding protein-associated factor 11-like 10; TATA-box binding protein associated factor 11 like 8.
ENSP00000491197 protein networkhttps://string-db.org/network/9606.ENSP00000491197Homeobox domain-containing protein.
HNRNPU protein networkhttps://string-db.org/network/9606.ENSP00000491215Heterogeneous nuclear ribonucleoprotein U; DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, m [...]
PARL-2 protein networkhttps://string-db.org/network/9606.ENSP00000491227Presenilins-associated rhomboid-like protein, mitochondrial.
B3GNT10 protein networkhttps://string-db.org/network/9606.ENSP00000491256Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC100288842; Putative glycosyltransferase; Belongs to the glycosyltransferase 2 family.
FIGNL2 protein networkhttps://string-db.org/network/9606.ENSP00000491257Putative fidgetin-like protein 2; Fidgetin like 2; Belongs to the AAA ATPase family.
PRAMEF13 protein networkhttps://string-db.org/network/9606.ENSP00000491259PRAME family member 13; Belongs to the PRAME family.
KDM4F protein networkhttps://string-db.org/network/9606.ENSP00000491279Lysine demethylase 4F.
DUXB protein networkhttps://string-db.org/network/9606.ENSP00000491301Double homeobox B.
ST3GAL5 protein networkhttps://string-db.org/network/9606.ENSP00000491316Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide).
TRIM75P protein networkhttps://string-db.org/network/9606.ENSP00000491320Putative tripartite motif-containing protein 75; Tripartite motif containing 75, pseudogene; Belongs to the TRIM/RBCC family.
PRR33 protein networkhttps://string-db.org/network/9606.ENSP00000491327Proline-rich protein 33; Proline rich 33.
TAF11L13 protein networkhttps://string-db.org/network/9606.ENSP00000491332TATA-box-binding protein-associated factor 11-like 13; TATA-box binding protein associated factor 11 like 13.
LOC102724334 protein networkhttps://string-db.org/network/9606.ENSP00000491341Histone H2B type F-S-like.
TAF11L7 protein networkhttps://string-db.org/network/9606.ENSP00000491351TATA-box binding protein associated factor 11 like 7.
LRRC8B protein networkhttps://string-db.org/network/9606.ENSP00000491377Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...]
TAF11L6 protein networkhttps://string-db.org/network/9606.ENSP00000491385TATA-box binding protein associated factor 11 like 6.
INTS6L protein networkhttps://string-db.org/network/9606.ENSP00000491427Integrator complex subunit 6 like.
TAF11L14 protein networkhttps://string-db.org/network/9606.ENSP00000491472TATA-box-binding protein-associated factor 11-like 14; TATA-box binding protein associated factor 11 like 14.
TAF11L4 protein networkhttps://string-db.org/network/9606.ENSP00000491494TATA-box-binding protein-associated factor 11-like 4; TATA-box binding protein associated factor 11 like 4.
ATG9B protein networkhttps://string-db.org/network/9606.ENSP00000491504Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore [...]
RTTN protein networkhttps://string-db.org/network/9606.ENSP00000491507Rotatin; Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, [...]
SCART1 protein networkhttps://string-db.org/network/9606.ENSP00000491516Scavenger receptor cysteine-rich domain-containing protein SCART1; May play a role in the immune system, perhaps as a co- receptor on alphabeta and gammadelta T-cells.
FDFT1 protein networkhttps://string-db.org/network/9606.ENSP00000491537Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1; Belongs to the phytoene/squalene synthase family.
RAB42 protein networkhttps://string-db.org/network/9606.ENSP00000491546Ras-related protein Rab-42; RAB42, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family.
ZNF888 protein networkhttps://string-db.org/network/9606.ENSP00000491567Zinc finger protein 888; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
ERFL protein networkhttps://string-db.org/network/9606.ENSP00000491574ETS domain-containing transcription factor ERF-like; ETS repressor factor like.
ENSP00000491596 protein networkhttps://string-db.org/network/9606.ENSP00000491596Novel protein.
CPHXL protein networkhttps://string-db.org/network/9606.ENSP00000491599Cytoplasmic polyadenylated homeobox like.
ENSP00000491651 protein networkhttps://string-db.org/network/9606.ENSP00000491651Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.
CCDC7 protein networkhttps://string-db.org/network/9606.ENSP00000491655Coiled-coil domain-containing protein 7; May play a role in tumorigenesis.
LPP protein networkhttps://string-db.org/network/9606.ENSP00000491657Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in sign [...]
SSU72P4 protein networkhttps://string-db.org/network/9606.ENSP00000491663SSU72 pseudogene 4.
SSU72P2 protein networkhttps://string-db.org/network/9606.ENSP00000491669SSU72 pseudogene 2.
CATSPERZ protein networkhttps://string-db.org/network/9606.ENSP00000491717Cation channel sperm-associated protein subunit zeta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm [...]
CSAG2 protein networkhttps://string-db.org/network/9606.ENSP00000491720Chondrosarcoma-associated gene 2/3 protein; CSAG family member 2.
BIVM-ERCC5 protein networkhttps://string-db.org/network/9606.ENSP00000491742DNA repair protein-complementing XP-G cells; BIVM-ERCC5 readthrough.
KCNH1-2 protein networkhttps://string-db.org/network/9606.ENSP00000491750Potassium voltage-gated channel subfamily H member 1.
TAF11L12 protein networkhttps://string-db.org/network/9606.ENSP00000491758TATA-box-binding protein-associated factor 11-like 12; TATA-box binding protein associated factor 11 like 12.
SSU72P3 protein networkhttps://string-db.org/network/9606.ENSP00000491768SSU72 pseudogene 3.
ZC3H11A protein networkhttps://string-db.org/network/9606.ENSP00000491830Zinc finger CCCH domain-containing protein 11A; Involved in nuclear mRNA export; probably mediated by association with the TREX complex.
TAF11L11 protein networkhttps://string-db.org/network/9606.ENSP00000491846TATA-box-binding protein-associated factor 11-like 11; TATA-box binding protein associated factor 11 like 11.
GAGE12F protein networkhttps://string-db.org/network/9606.ENSP00000491865G antigen 12F.
TAF11L10 protein networkhttps://string-db.org/network/9606.ENSP00000491873TATA-box binding protein associated factor 11 like 10.
SSU72P7 protein networkhttps://string-db.org/network/9606.ENSP00000491894SSU72 pseudogene 7.
MINDY4B protein networkhttps://string-db.org/network/9606.ENSP00000491923Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B; MINDY family member 4B; Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
C2orf81 protein networkhttps://string-db.org/network/9606.ENSP00000491941Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81.
SSU72P5 protein networkhttps://string-db.org/network/9606.ENSP00000491949SSU72 pseudogene 5.
IGLV10-54 protein networkhttps://string-db.org/network/9606.ENSP00000491969Immunoglobulin lambda variable 10-54.
PFKFB3 protein networkhttps://string-db.org/network/9606.ENSP000004920016-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family.
SPATA1 protein networkhttps://string-db.org/network/9606.ENSP00000492019Spermatogenesis-associated protein 1; Spermatogenesis associated 1.
PAX6 protein networkhttps://string-db.org/network/9606.ENSP00000492024Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic is [...]
NCBP2L protein networkhttps://string-db.org/network/9606.ENSP00000492033Nuclear cap binding protein subunit 2 like; Belongs to the RRM NCBP2 family.
TAF11L2 protein networkhttps://string-db.org/network/9606.ENSP00000492047Putative TAF11-like protein ENSP00000332601; TATA-box binding protein associated factor 11 like 2; Belongs to the TAF11 family.
PRSS41 protein networkhttps://string-db.org/network/9606.ENSP00000492058Serine protease 41; Belongs to the peptidase S1 family.
PERCC1 protein networkhttps://string-db.org/network/9606.ENSP00000492108Protein PERCC1; Plays a critical role in intestinal function. Acts by promoting the development of enteroendocrine cells (EECs) of the gastrointestinal tract and pancreas (By similarity). It is t [...]
ENSP00000492220 protein networkhttps://string-db.org/network/9606.ENSP00000492220DUF1907 domain-containing protein.
PIGN protein networkhttps://string-db.org/network/9606.ENSP00000492233GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4- [...]
KCTD7 protein networkhttps://string-db.org/network/9606.ENSP00000492240BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons.
LIAS protein networkhttps://string-db.org/network/9606.ENSP00000492260Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent [...]
GSTT4 protein networkhttps://string-db.org/network/9606.ENSP00000492273Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family.
CSAG3 protein networkhttps://string-db.org/network/9606.ENSP00000492276Chondrosarcoma-associated gene 2/3 protein; Drug-resistance related protein, its expression is associated with the chemotherapy resistant and neoplastic phenotype. May also be linked to the malig [...]
ENSP00000492303 protein networkhttps://string-db.org/network/9606.ENSP00000492303PAS domain-containing protein.
TLE7 protein networkhttps://string-db.org/network/9606.ENSP00000492311Transducin-like enhancer protein 7; TLE family member 7; Belongs to the WD repeat Groucho/TLE family.
PRICKLE2 protein networkhttps://string-db.org/network/9606.ENSP00000492363Prickle planar cell polarity protein 2.
PYDC2 protein networkhttps://string-db.org/network/9606.ENSP00000492367Pyrin domain-containing protein 2; May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF- kappa [...]
hCG_1642624 protein networkhttps://string-db.org/network/9606.ENSP00000492384HCG1642624, isoform CRA_a.
TMEM225B protein networkhttps://string-db.org/network/9606.ENSP00000492416Transmembrane protein 225B.
NUDT4B protein networkhttps://string-db.org/network/9606.ENSP00000492425Nudix hydrolase 4B.
PRAMEF33 protein networkhttps://string-db.org/network/9606.ENSP00000492439PRAME family member 33; Belongs to the PRAME family.
RPS10-NUDT3 protein networkhttps://string-db.org/network/9606.ENSP00000492441RPS10-NUDT3 readthrough.
TAF11L9 protein networkhttps://string-db.org/network/9606.ENSP00000492463TATA-box-binding protein-associated factor 11-like 9; TATA-box binding protein associated factor 11 like 9.
SSU72P8 protein networkhttps://string-db.org/network/9606.ENSP00000492512SSU72 pseudogene 8.
PMIS2 protein networkhttps://string-db.org/network/9606.ENSP00000492557Transmembrane protein PMIS2; May play a role in spermatozoa mobility. Belongs to the CD225/Dispanin family.
GNG14 protein networkhttps://string-db.org/network/9606.ENSP00000492612Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14; G protein subunit gamma 14.
ARL9 protein networkhttps://string-db.org/network/9606.ENSP00000492671ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9.
PLEKHG7 protein networkhttps://string-db.org/network/9606.ENSP00000492692Pleckstrin homology and RhoGEF domain containing G7.
TRIM43B protein networkhttps://string-db.org/network/9606.ENSP00000492719Tripartite motif containing 43B; Belongs to the TRIM/RBCC family.
ENSP00000492745 protein networkhttps://string-db.org/network/9606.ENSP00000492745MFS domain-containing protein.
LINC02218 protein networkhttps://string-db.org/network/9606.ENSP00000492752Long intergenic non-protein coding RNA 2218.
FOXL3 protein networkhttps://string-db.org/network/9606.ENSP00000492766Fork-head domain-containing protein.
TAF11L3 protein networkhttps://string-db.org/network/9606.ENSP00000492787TATA-box-binding protein-associated factor 11-like 3; TATA-box binding protein associated factor 11 like 3.
ZNF705E protein networkhttps://string-db.org/network/9606.ENSP00000492790Putative zinc finger protein 705E; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
SPIN3 protein networkhttps://string-db.org/network/9606.ENSP00000492795Spindlin-3; Exhibits H3K4me3-binding activity. Belongs to the SPIN/STSY family.
ENSP00000492798 protein networkhttps://string-db.org/network/9606.ENSP00000492798Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.
TAF11L5 protein networkhttps://string-db.org/network/9606.ENSP00000492874TATA-box binding protein associated factor 11 like 5.
OR2B11 protein networkhttps://string-db.org/network/9606.ENSP00000492892Olfactory receptor 2B11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR14J1 protein networkhttps://string-db.org/network/9606.ENSP00000492893Olfactory receptor 14J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6Y1 protein networkhttps://string-db.org/network/9606.ENSP00000492894Olfactory receptor 6Y1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T29 protein networkhttps://string-db.org/network/9606.ENSP00000492895Olfactory receptor 2T29; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10J1 protein networkhttps://string-db.org/network/9606.ENSP00000492902Olfactory receptor 10J1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10G7 protein networkhttps://string-db.org/network/9606.ENSP00000492905Olfactory receptor 10G7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6B1 protein networkhttps://string-db.org/network/9606.ENSP00000492907Olfactory receptor 6B1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10A6 protein networkhttps://string-db.org/network/9606.ENSP00000492919Olfactory receptor 10A6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR11H2 protein networkhttps://string-db.org/network/9606.ENSP00000492923Olfactory receptor 11H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR9Q2 protein networkhttps://string-db.org/network/9606.ENSP00000492924Olfactory receptor 9Q2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6P1 protein networkhttps://string-db.org/network/9606.ENSP00000492936Olfactory receptor 6P1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5P3 protein networkhttps://string-db.org/network/9606.ENSP00000492944Olfactory receptor 5P3; Odorant receptor (Potential). May be involved in taste perception.
OR2T2 protein networkhttps://string-db.org/network/9606.ENSP00000492947Olfactory receptor 2T2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T11 protein networkhttps://string-db.org/network/9606.ENSP00000492951Olfactory receptor 2T11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5H1 protein networkhttps://string-db.org/network/9606.ENSP00000492953Olfactory receptor 5H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5AN1 protein networkhttps://string-db.org/network/9606.ENSP00000492957Olfactory receptor 5AN1; Odorant receptor involved in the detection of muscone, cyclopentadecanone, cyclopentadecanol, and omega-pentadecalactone. The activity of this receptor is mediated by G p [...]
OR2V1 protein networkhttps://string-db.org/network/9606.ENSP00000492958Olfactory receptor 2V1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2H2 protein networkhttps://string-db.org/network/9606.ENSP00000492959Olfactory receptor 2H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51A4 protein networkhttps://string-db.org/network/9606.ENSP00000492963Olfactory receptor 51A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4C11 protein networkhttps://string-db.org/network/9606.ENSP00000492971Olfactory receptor 4C11; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10G3 protein networkhttps://string-db.org/network/9606.ENSP00000492973Olfactory receptor 10G3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2M2 protein networkhttps://string-db.org/network/9606.ENSP00000492974Olfactory receptor 2M2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5A2 protein networkhttps://string-db.org/network/9606.ENSP00000492975Olfactory receptor 5A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6C1 protein networkhttps://string-db.org/network/9606.ENSP00000492978Olfactory receptor 6C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2M3 protein networkhttps://string-db.org/network/9606.ENSP00000492981Olfactory receptor 2M3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4M1 protein networkhttps://string-db.org/network/9606.ENSP00000492985Olfactory receptor 4M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51D1 protein networkhttps://string-db.org/network/9606.ENSP00000492986Olfactory receptor 51D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6A2 protein networkhttps://string-db.org/network/9606.ENSP00000492990Olfactory receptor 6A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2M4 protein networkhttps://string-db.org/network/9606.ENSP00000492992Olfactory receptor 2M4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T35 protein networkhttps://string-db.org/network/9606.ENSP00000492995Olfactory receptor 2T35; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8A1 protein networkhttps://string-db.org/network/9606.ENSP00000492999Olfactory receptor 8A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T12 protein networkhttps://string-db.org/network/9606.ENSP00000493000Olfactory receptor 2T12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10Z1 protein networkhttps://string-db.org/network/9606.ENSP00000493003Olfactory receptor 10Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51M1 protein networkhttps://string-db.org/network/9606.ENSP00000493005Olfactory receptor 51M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4K2 protein networkhttps://string-db.org/network/9606.ENSP00000493007Olfactory receptor 4K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4D9 protein networkhttps://string-db.org/network/9606.ENSP00000493010Olfactory receptor 4D9; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52K1 protein networkhttps://string-db.org/network/9606.ENSP00000493011Olfactory receptor 52K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8B8 protein networkhttps://string-db.org/network/9606.ENSP00000493014Olfactory receptor 8B8; Odorant receptor (Potential). May be involved in taste perception.
OR51L1 protein networkhttps://string-db.org/network/9606.ENSP00000493015Olfactory receptor 51L1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51I2 protein networkhttps://string-db.org/network/9606.ENSP00000493016Olfactory receptor 51I2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2L3 protein networkhttps://string-db.org/network/9606.ENSP00000493020Olfactory receptor 2L3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10K1 protein networkhttps://string-db.org/network/9606.ENSP00000493023Olfactory receptor 10K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR14A16 protein networkhttps://string-db.org/network/9606.ENSP00000493024Olfactory receptor 14A16; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR7C1 protein networkhttps://string-db.org/network/9606.ENSP00000493026Olfactory receptor 7C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8H2 protein networkhttps://string-db.org/network/9606.ENSP00000493031Olfactory receptor 8H2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6C3 protein networkhttps://string-db.org/network/9606.ENSP00000493034Olfactory receptor 6C3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6B3 protein networkhttps://string-db.org/network/9606.ENSP00000493035Olfactory receptor 6B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2AP1 protein networkhttps://string-db.org/network/9606.ENSP00000493043Olfactory receptor 2AP1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
GVQW2 protein networkhttps://string-db.org/network/9606.ENSP00000493046Protein GVQW2.
OR51F2 protein networkhttps://string-db.org/network/9606.ENSP00000493050Olfactory receptor 51F2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR7A10 protein networkhttps://string-db.org/network/9606.ENSP00000493055Olfactory receptor 7A10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T5 protein networkhttps://string-db.org/network/9606.ENSP00000493066Olfactory receptor 2T5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5M3 protein networkhttps://string-db.org/network/9606.ENSP00000493070Olfactory receptor 5M3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2AG1 protein networkhttps://string-db.org/network/9606.ENSP00000493074Olfactory receptor 2AG1; Odorant receptor.
OR2L13 protein networkhttps://string-db.org/network/9606.ENSP00000493075Olfactory receptor 2L13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5H15 protein networkhttps://string-db.org/network/9606.ENSP00000493082Olfactory receptor 5H15; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52E4 protein networkhttps://string-db.org/network/9606.ENSP00000493085Olfactory receptor 52E4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4C3 protein networkhttps://string-db.org/network/9606.ENSP00000493096Olfactory receptor 4C3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SCYGR5 protein networkhttps://string-db.org/network/9606.ENSP00000493101Small cysteine and glycine repeat containing 5.
FAM71F2 protein networkhttps://string-db.org/network/9606.ENSP00000493102Protein FAM71F2; Family with sequence similarity 71 member F2; Belongs to the FAM71 family.
OR1D2 protein networkhttps://string-db.org/network/9606.ENSP00000493103Olfactory receptor 1D2; Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitr [...]
OR4K14 protein networkhttps://string-db.org/network/9606.ENSP00000493106Olfactory receptor 4K14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR1M1 protein networkhttps://string-db.org/network/9606.ENSP00000493107Olfactory receptor 1M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SCYGR1 protein networkhttps://string-db.org/network/9606.ENSP00000493109Small cysteine and glycine repeat-containing protein 1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated [...]
OR13G1 protein networkhttps://string-db.org/network/9606.ENSP00000493110Olfactory receptor 13G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4E1 protein networkhttps://string-db.org/network/9606.ENSP00000493111Olfactory receptor 4E1; Odorant receptor.
OR8B3 protein networkhttps://string-db.org/network/9606.ENSP00000493120Olfactory receptor 8B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SRGAP2B protein networkhttps://string-db.org/network/9606.ENSP00000493121SLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2.
OR5M1 protein networkhttps://string-db.org/network/9606.ENSP00000493124Olfactory receptor 5M1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10A2 protein networkhttps://string-db.org/network/9606.ENSP00000493131Olfactory receptor 10A2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4D2 protein networkhttps://string-db.org/network/9606.ENSP00000493137Olfactory receptor 4D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6N2 protein networkhttps://string-db.org/network/9606.ENSP00000493148Olfactory receptor 6N2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR9A4 protein networkhttps://string-db.org/network/9606.ENSP00000493151Olfactory receptor 9A4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SCYGR7 protein networkhttps://string-db.org/network/9606.ENSP00000493152Small cysteine and glycine repeat-containing protein 7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated [...]
PPT1 protein networkhttps://string-db.org/network/9606.ENSP00000493153Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl c [...]
OR2A12 protein networkhttps://string-db.org/network/9606.ENSP00000493157Olfactory receptor 2A12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51A7 protein networkhttps://string-db.org/network/9606.ENSP00000493162Olfactory receptor 51A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8J3 protein networkhttps://string-db.org/network/9606.ENSP00000493166Olfactory receptor 8J3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
TMDD1 protein networkhttps://string-db.org/network/9606.ENSP00000493167Transmembrane and death domain 1.
OR1A1 protein networkhttps://string-db.org/network/9606.ENSP00000493179Olfactory receptor 1A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6C4 protein networkhttps://string-db.org/network/9606.ENSP00000493181Olfactory receptor 6C4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
FOXO6 protein networkhttps://string-db.org/network/9606.ENSP00000493184Forkhead box protein O6; Transcriptional activator.
OR52N5 protein networkhttps://string-db.org/network/9606.ENSP00000493190Olfactory receptor 52N5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5A1 protein networkhttps://string-db.org/network/9606.ENSP00000493195Olfactory receptor 5A1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR7D2 protein networkhttps://string-db.org/network/9606.ENSP00000493200Olfactory receptor 7D2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2AK2 protein networkhttps://string-db.org/network/9606.ENSP00000493202Olfactory receptor 2AK2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4K1 protein networkhttps://string-db.org/network/9606.ENSP00000493205Olfactory receptor 4K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2V2 protein networkhttps://string-db.org/network/9606.ENSP00000493207Olfactory receptor 2V2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5B3 protein networkhttps://string-db.org/network/9606.ENSP00000493217Olfactory receptor 5B3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MFSD8 protein networkhttps://string-db.org/network/9606.ENSP00000493218Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients.
OR6C2 protein networkhttps://string-db.org/network/9606.ENSP00000493222Olfactory receptor 6C2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5H14 protein networkhttps://string-db.org/network/9606.ENSP00000493226Olfactory receptor 5H14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10D3 protein networkhttps://string-db.org/network/9606.ENSP00000493231Putative olfactory receptor 10D3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
MICU1 protein networkhttps://string-db.org/network/9606.ENSP00000493232Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodi [...]
OR4D1 protein networkhttps://string-db.org/network/9606.ENSP00000493234Olfactory receptor 4D1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8B2 protein networkhttps://string-db.org/network/9606.ENSP00000493235Olfactory receptor 8B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T10 protein networkhttps://string-db.org/network/9606.ENSP00000493236Olfactory receptor 2T10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10H5 protein networkhttps://string-db.org/network/9606.ENSP00000493242Olfactory receptor 10H5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ZFHX3 protein networkhttps://string-db.org/network/9606.ENSP00000493252Zinc finger homeobox protein 3; Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In c [...]
OR6N1 protein networkhttps://string-db.org/network/9606.ENSP00000493254Olfactory receptor 6N1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR9G1 protein networkhttps://string-db.org/network/9606.ENSP00000493255Olfactory receptor 9G1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5B12 protein networkhttps://string-db.org/network/9606.ENSP00000493263Olfactory receptor 5B12; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5K1 protein networkhttps://string-db.org/network/9606.ENSP00000493267Olfactory receptor 5K1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5V1 protein networkhttps://string-db.org/network/9606.ENSP00000493269Olfactory receptor 5V1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8K3 protein networkhttps://string-db.org/network/9606.ENSP00000493271Olfactory receptor 8K3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52N1 protein networkhttps://string-db.org/network/9606.ENSP00000493272Olfactory receptor 52N1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
ENSP00000493273 protein networkhttps://string-db.org/network/9606.ENSP00000493273Uncharacterized protein.
C3orf56 protein networkhttps://string-db.org/network/9606.ENSP00000493276Putative uncharacterized protein C3orf56; Chromosome 3 open reading frame 56.
OR7A17 protein networkhttps://string-db.org/network/9606.ENSP00000493283Olfactory receptor 7A17; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T8 protein networkhttps://string-db.org/network/9606.ENSP00000493286Olfactory receptor 2T8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10H3 protein networkhttps://string-db.org/network/9606.ENSP00000493287Olfactory receptor 10H3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8G1 protein networkhttps://string-db.org/network/9606.ENSP00000493289Olfactory receptor 8G1; Odorant receptor.
OR2A5 protein networkhttps://string-db.org/network/9606.ENSP00000493295Olfactory receptor 2A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10K2 protein networkhttps://string-db.org/network/9606.ENSP00000493297Olfactory receptor 10K2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52A5 protein networkhttps://string-db.org/network/9606.ENSP00000493298Olfactory receptor 52A5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2AT4 protein networkhttps://string-db.org/network/9606.ENSP00000493299Olfactory receptor 2AT4; Olfactory receptor. Activated by the synthetic sandalwood odorant sandalore. Endogenous ligand is unknown (Probable). The activity of this receptor is propably mediated b [...]
PNPO protein networkhttps://string-db.org/network/9606.ENSP00000493302Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
OR10A3 protein networkhttps://string-db.org/network/9606.ENSP00000493303Olfactory receptor 10A3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4N5 protein networkhttps://string-db.org/network/9606.ENSP00000493307Olfactory receptor 4N5; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52H1 protein networkhttps://string-db.org/network/9606.ENSP00000493308Olfactory receptor 52H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2J1 protein networkhttps://string-db.org/network/9606.ENSP00000493312Olfactory receptor 2J1; Odorant receptor.
OR8H1 protein networkhttps://string-db.org/network/9606.ENSP00000493316Olfactory receptor 8H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR56A3 protein networkhttps://string-db.org/network/9606.ENSP00000493319Olfactory receptor 56A3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2A7 protein networkhttps://string-db.org/network/9606.ENSP00000493320Olfactory receptor 2A7; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2Z1 protein networkhttps://string-db.org/network/9606.ENSP00000493322Olfactory receptor 2Z1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR51G2 protein networkhttps://string-db.org/network/9606.ENSP00000493323Olfactory receptor 51G2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5AS1 protein networkhttps://string-db.org/network/9606.ENSP00000493325Olfactory receptor 5AS1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4N2 protein networkhttps://string-db.org/network/9606.ENSP00000493327Olfactory receptor 4N2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
SMIM38 protein networkhttps://string-db.org/network/9606.ENSP00000493332Small integral membrane protein 38.
OR2A42 protein networkhttps://string-db.org/network/9606.ENSP00000493333Olfactory receptor 2A1/2A42; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4C6 protein networkhttps://string-db.org/network/9606.ENSP00000493334Olfactory receptor 4C6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR52N4 protein networkhttps://string-db.org/network/9606.ENSP00000493338Olfactory receptor 52N4; Odorant receptor.
OR5H6 protein networkhttps://string-db.org/network/9606.ENSP00000493340Olfactory receptor 5H6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6F1 protein networkhttps://string-db.org/network/9606.ENSP00000493342Olfactory receptor 6F1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2A25 protein networkhttps://string-db.org/network/9606.ENSP00000493343Olfactory receptor 2A25; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
C2orf83 protein networkhttps://string-db.org/network/9606.ENSP00000493351Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83.
OR2A14 protein networkhttps://string-db.org/network/9606.ENSP00000493353Olfactory receptor 2A14; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10G4 protein networkhttps://string-db.org/network/9606.ENSP00000493354Olfactory receptor 10G4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2G6 protein networkhttps://string-db.org/network/9606.ENSP00000493355Olfactory receptor 2G6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
CYTH2 protein networkhttps://string-db.org/network/9606.ENSP00000493357Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similar [...]
OR2AG2 protein networkhttps://string-db.org/network/9606.ENSP00000493362Olfactory receptor 2AG2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5T1 protein networkhttps://string-db.org/network/9606.ENSP00000493364Olfactory receptor 5T1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8D1 protein networkhttps://string-db.org/network/9606.ENSP00000493365Olfactory receptor 8D1; Odorant receptor (Potential). May be involved in taste perception.
OR2T6 protein networkhttps://string-db.org/network/9606.ENSP00000493366Olfactory receptor 2T6; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR9I1 protein networkhttps://string-db.org/network/9606.ENSP00000493370Olfactory receptor 9I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
PHGDH protein networkhttps://string-db.org/network/9606.ENSP00000493382D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Als [...]
OR4P4 protein networkhttps://string-db.org/network/9606.ENSP00000493384Olfactory receptor 4P4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2C3 protein networkhttps://string-db.org/network/9606.ENSP00000493385Olfactory receptor family 2 subfamily C member 3.
OR4E2 protein networkhttps://string-db.org/network/9606.ENSP00000493386Olfactory receptor 4E2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR4S2 protein networkhttps://string-db.org/network/9606.ENSP00000493389Olfactory receptor 4S2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR8D4 protein networkhttps://string-db.org/network/9606.ENSP00000493391Olfactory receptor 8D4; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR1I1 protein networkhttps://string-db.org/network/9606.ENSP00000493393Olfactory receptor 1I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2J2 protein networkhttps://string-db.org/network/9606.ENSP00000493401Olfactory receptor 2J2; Odorant receptor.
OR7D4 protein networkhttps://string-db.org/network/9606.ENSP00000493404Olfactory receptor 7D4; Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
OR4K13 protein networkhttps://string-db.org/network/9606.ENSP00000493405Olfactory receptor 4K13; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2L2 protein networkhttps://string-db.org/network/9606.ENSP00000493410Olfactory receptor 2L2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR1L8 protein networkhttps://string-db.org/network/9606.ENSP00000493411Olfactory receptor 1L8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5B2 protein networkhttps://string-db.org/network/9606.ENSP00000493419Olfactory receptor 5B2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR6C75 protein networkhttps://string-db.org/network/9606.ENSP00000493430Olfactory receptor 6C75; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR5AU1 protein networkhttps://string-db.org/network/9606.ENSP00000493431Olfactory receptor 5AU1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T27 protein networkhttps://string-db.org/network/9606.ENSP00000493434Olfactory receptor 2T27; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR10H1 protein networkhttps://string-db.org/network/9606.ENSP00000493436Olfactory receptor 10H1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2T33 protein networkhttps://string-db.org/network/9606.ENSP00000493437Olfactory receptor 2T33; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
OR2J3 protein networkhttps://string-db.org/network/9606.ENSP00000493439Olfactory receptor 2J3; Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'.
OR2A1 protein networkhttps://string-db.org/network/9606.ENSP00000493454Olfactory receptor family 2 subfamily A member 1.
OR1C1 protein networkhttps://string-db.org/network/9606.ENSP00000493457Olfactory receptor 1C1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
DEXI protein networkhttps://string-db.org/network/9606.ENSP00000493467Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family.
SLC25A48 protein networkhttps://string-db.org/network/9606.ENSP00000493514Solute carrier family 25 member 48.
TM9SF2 protein networkhttps://string-db.org/network/9606.ENSP00000493515Transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter.
SAMHD1 protein networkhttps://string-db.org/network/9606.ENSP00000493536Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stall [...]
TEX15 protein networkhttps://string-db.org/network/9606.ENSP00000493555Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chro [...]
VPS13C protein networkhttps://string-db.org/network/9606.ENSP00000493560Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-med [...]
MYH14 protein networkhttps://string-db.org/network/9606.ENSP00000493594Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
ENSP00000493607 protein networkhttps://string-db.org/network/9606.ENSP00000493607Uncharacterized protein.
FYB1 protein networkhttps://string-db.org/network/9606.ENSP00000493623FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoske [...]
SMIM41 protein networkhttps://string-db.org/network/9606.ENSP00000493663Small integral membrane protein 41.
DOCK10 protein networkhttps://string-db.org/network/9606.ENSP00000493664Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Pu [...]
PTP4A2 protein networkhttps://string-db.org/network/9606.ENSP00000493688Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type I [...]
ENSP00000493691 protein networkhttps://string-db.org/network/9606.ENSP00000493691Uncharacterized protein.
ENSP00000493701 protein networkhttps://string-db.org/network/9606.ENSP00000493701Ubiquitin-like domain-containing protein.
RAD51 protein networkhttps://string-db.org/network/9606.ENSP00000493712DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA [...]
OR2I1P protein networkhttps://string-db.org/network/9606.ENSP00000493715Putative olfactory receptor 2I1; Odorant receptor; Belongs to the G-protein coupled receptor 1 family.
EFNB2 protein networkhttps://string-db.org/network/9606.ENSP00000493716Ephrin-B2; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithel [...]
GRB10 protein networkhttps://string-db.org/network/9606.ENSP00000493728Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals fro [...]
COMMD7-2 protein networkhttps://string-db.org/network/9606.ENSP00000493768COMM domain-containing protein 7.
ENSP00000493780 protein networkhttps://string-db.org/network/9606.ENSP00000493780Uncharacterized protein; Belongs to the MAGUK family.
LRRC9 protein networkhttps://string-db.org/network/9606.ENSP00000493790Leucine-rich repeat-containing protein 9; Leucine rich repeat containing 9.
HNRNPA1P48 protein networkhttps://string-db.org/network/9606.ENSP00000493805Heterogeneous nuclear ribonucleoprotein A1 pseudogene 48.
ST3GAL3 protein networkhttps://string-db.org/network/9606.ENSP00000493823CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alph [...]
ENSP00000493899 protein networkhttps://string-db.org/network/9606.ENSP00000493899Novel protein.
SNTG1 protein networkhttps://string-db.org/network/9606.ENSP00000493900Gamma-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystro [...]
GIPC3 protein networkhttps://string-db.org/network/9606.ENSP00000493901PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.
FOXC1 protein networkhttps://string-db.org/network/9606.ENSP00000493906Forkhead box protein C1; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin developm [...]
RPGRIP1L protein networkhttps://string-db.org/network/9606.ENSP00000493946Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, [...]
ZNF746 protein networkhttps://string-db.org/network/9606.ENSP00000493970Zinc finger protein 746; Transcription repressor that specifically binds to the 5'- TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby pla [...]
PDE8B-2 protein networkhttps://string-db.org/network/9606.ENSP00000493971Phosphodiesterase 8B.
KNG1 protein networkhttps://string-db.org/network/9606.ENSP00000493985Low molecular weight growth-promoting factor; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally pr [...]
SLC52A3 protein networkhttps://string-db.org/network/9606.ENSP00000494009Solute carrier family 52, riboflavin transporter, member 3; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemic [...]
SLC26A4 protein networkhttps://string-db.org/network/9606.ENSP00000494017Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
DDX3X protein networkhttps://string-db.org/network/9606.ENSP00000494040ATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate speci [...]
SEPTIN3 protein networkhttps://string-db.org/network/9606.ENSP00000494051Neuronal-specific septin-3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase sup [...]
MUC2 protein networkhttps://string-db.org/network/9606.ENSP00000494061Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents a [...]
TMF1 protein networkhttps://string-db.org/network/9606.ENSP00000494067TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from [...]
XG protein networkhttps://string-db.org/network/9606.ENSP00000494087Xg glycoprotein; Belongs to the CD99 family.
TPM4 protein networkhttps://string-db.org/network/9606.ENSP00000494125Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebra [...]
SLC6A1 protein networkhttps://string-db.org/network/9606.ENSP00000494136Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals.
DSE protein networkhttps://string-db.org/network/9606.ENSP00000494147Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.
CBLC protein networkhttps://string-db.org/network/9606.ENSP00000494162E3 ubiquitin-protein ligase CBL-C; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting th [...]
ENSP00000494172 protein networkhttps://string-db.org/network/9606.ENSP00000494172RING-type domain-containing protein.
HBB protein networkhttps://string-db.org/network/9606.ENSP00000494175Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as D [...]
DDIT3-2 protein networkhttps://string-db.org/network/9606.ENSP00000494177DDIT3 upstream open reading frame protein.
OR5BS1P protein networkhttps://string-db.org/network/9606.ENSP00000494254Olfactory receptor family 5 subfamily BS member 1 pseudogene.
HOXA1 protein networkhttps://string-db.org/network/9606.ENSP00000494260Homeobox protein Hox-A1; Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovasc [...]
PATJ protein networkhttps://string-db.org/network/9606.ENSP00000494277InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane (Probable). May regulate protein targeting, cell polarity and integrity of ti [...]
ZNF723 protein networkhttps://string-db.org/network/9606.ENSP00000494306Zinc finger protein 723; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
GPR174 protein networkhttps://string-db.org/network/9606.ENSP00000494310Probable G-protein coupled receptor 174; Putative receptor for purines coupled to G-proteins.
ABCC8 protein networkhttps://string-db.org/network/9606.ENSP00000494321ATP-binding cassette sub-family C member 8; Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Belongs to the ABC trans [...]
KDSR protein networkhttps://string-db.org/network/9606.ENSP000004943523-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family.
UPK3BL2 protein networkhttps://string-db.org/network/9606.ENSP00000494359Uroplakin 3B like 2.
SUCLA2 protein networkhttps://string-db.org/network/9606.ENSP00000494360Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synt [...]
MTAP protein networkhttps://string-db.org/network/9606.ENSP00000494373S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of M [...]
OOSP4B protein networkhttps://string-db.org/network/9606.ENSP00000494382Oocyte secreted protein family member 4B.
ANKRD40CL protein networkhttps://string-db.org/network/9606.ENSP00000494384Putative ANKRD40 C-terminal-like protein; ANKRD40 C-terminal like.
GJB6 protein networkhttps://string-db.org/network/9606.ENSP00000494468Gap junction beta-6 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...]
TRANK1 protein networkhttps://string-db.org/network/9606.ENSP00000494480Tetratricopeptide repeat and ankyrin repeat containing 1.
OOSP1 protein networkhttps://string-db.org/network/9606.ENSP00000494485Putative oocyte-secreted protein 1 homolog; May be involved in cell differentiation; Belongs to the PLAC1 family.
THPO protein networkhttps://string-db.org/network/9606.ENSP00000494504Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. [...]
CTCF protein networkhttps://string-db.org/network/9606.ENSP00000494538Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing intera [...]
MYO1F protein networkhttps://string-db.org/network/9606.ENSP00000494550Unconventional myosin-If; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...]
TMIE protein networkhttps://string-db.org/network/9606.ENSP00000494576Transmembrane inner ear expressed protein; Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways suc [...]
ABCC4 protein networkhttps://string-db.org/network/9606.ENSP00000494609Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A [...]
HK1 protein networkhttps://string-db.org/network/9606.ENSP00000494664Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glu [...]
ENSP00000494667 protein networkhttps://string-db.org/network/9606.ENSP00000494667Novel protein, ortholog of mouse Tomt.
TBC1D24 protein networkhttps://string-db.org/network/9606.ENSP00000494678TBC1 domain family member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 functi [...]
TMC1 protein networkhttps://string-db.org/network/9606.ENSP00000494684Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family.
SIX1 protein networkhttps://string-db.org/network/9606.ENSP00000494686Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several or [...]
EPS8 protein networkhttps://string-db.org/network/9606.ENSP00000494689Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its asso [...]
RPL9 protein networkhttps://string-db.org/network/9606.ENSP00000494697Ribosomal protein L9.
HBD protein networkhttps://string-db.org/network/9606.ENSP00000494708Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.
ACTB protein networkhttps://string-db.org/network/9606.ENSP00000494750Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in [...]
CASK protein networkhttps://string-db.org/network/9606.ENSP00000494788Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and [...]
SNRPN protein networkhttps://string-db.org/network/9606.ENSP00000494831Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events.
KRBA2 protein networkhttps://string-db.org/network/9606.ENSP00000494883KRAB-A domain containing 2.
TECTB protein networkhttps://string-db.org/network/9606.ENSP00000494896Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepith [...]
UBE2T protein networkhttps://string-db.org/network/9606.ENSP00000494957Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induc [...]
HARS2 protein networkhttps://string-db.org/network/9606.ENSP00000494965Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an am [...]
PITX2 protein networkhttps://string-db.org/network/9606.ENSP00000495061Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. [...]
CCDC82 protein networkhttps://string-db.org/network/9606.ENSP00000495063Coiled-coil domain containing 82.
NMNAT3 protein networkhttps://string-db.org/network/9606.ENSP00000495112Nicotinamide nucleotide adenylyltransferase 3.
SRP72 protein networkhttps://string-db.org/network/9606.ENSP00000495128Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA on [...]
H2BE1 protein networkhttps://string-db.org/network/9606.ENSP00000495192H2B.E variant histone 1.
TBCE-2 protein networkhttps://string-db.org/network/9606.ENSP00000495202Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct o [...]
KCTD11 protein networkhttps://string-db.org/network/9606.ENSP00000495203BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal g [...]
SPTA1 protein networkhttps://string-db.org/network/9606.ENSP00000495214Spectrin alpha chain, erythrocytic 1; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the c [...]
CHD8 protein networkhttps://string-db.org/network/9606.ENSP00000495240Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structu [...]
MYO15B protein networkhttps://string-db.org/network/9606.ENSP00000495242Unconventional myosin-XVB; Unknown, due to the absence of a functional motor domain.
MANBA protein networkhttps://string-db.org/network/9606.ENSP00000495247Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides; Belongs to the glycosyl hydrolase 2 f [...]
OOSP3 protein networkhttps://string-db.org/network/9606.ENSP00000495263Oocyte secreted protein family member 3.
RPS7 protein networkhttps://string-db.org/network/9606.ENSP0000049527340S ribosomal protein S7; Required for rRNA maturation.
AP3D1 protein networkhttps://string-db.org/network/9606.ENSP00000495274AP-3 complex subunit delta-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...]
SLC12A1 protein networkhttps://string-db.org/network/9606.ENSP00000495332Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential ro [...]
CTNNB1 protein networkhttps://string-db.org/network/9606.ENSP00000495360Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on [...]
SLC19A3 protein networkhttps://string-db.org/network/9606.ENSP00000495385Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Belongs to the reduced folate carrier (RFC) transporte [...]
MUC19 protein networkhttps://string-db.org/network/9606.ENSP00000495398Mucin-19; May function in ocular mucus homeostasis.
TRIM66 protein networkhttps://string-db.org/network/9606.ENSP00000495413Tripartite motif-containing protein 66; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as [...]
C20orf203 protein networkhttps://string-db.org/network/9606.ENSP00000495424Uncharacterized protein C20orf203; Chromosome 20 open reading frame 203.
ASAH2B protein networkhttps://string-db.org/network/9606.ENSP00000495463Putative inactive neutral ceramidase B; N-acylsphingosine amidohydrolase 2B.
MYO15A protein networkhttps://string-db.org/network/9606.ENSP00000495481Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...]
SLITRK6 protein networkhttps://string-db.org/network/9606.ENSP00000495507SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision; Belongs to the SLITRK family.
ENO1 protein networkhttps://string-db.org/network/9606.ENSP00000495530Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypox [...]
RPGR protein networkhttps://string-db.org/network/9606.ENSP00000495537X-linked retinitis pigmentosa GTPase regulator; Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filamen [...]
TBL1X protein networkhttps://string-db.org/network/9606.ENSP00000495556F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an e [...]
KCNJ10 protein networkhttps://string-db.org/network/9606.ENSP00000495557ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a grea [...]
VPS45 protein networkhttps://string-db.org/network/9606.ENSP00000495563Vacuolar protein sorting-associated protein 45; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.
GRHL2 protein networkhttps://string-db.org/network/9606.ENSP00000495564Grainyhead-like protein 2 homolog; Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'- AACCGGTT-3 [...]
PTPRQ protein networkhttps://string-db.org/network/9606.ENSP00000495607Phosphatidylinositol phosphatase PTPRQ; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5- bisphosphate (PIP2) level in [...]
MEA1 protein networkhttps://string-db.org/network/9606.ENSP00000495612Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development.
CHN2-2 protein networkhttps://string-db.org/network/9606.ENSP00000495614Beta-chimaerin.
ARHGEF7 protein networkhttps://string-db.org/network/9606.ENSP00000495631Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Pro [...]
RPL35A protein networkhttps://string-db.org/network/9606.ENSP0000049567260S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator a [...]
LINC02203 protein networkhttps://string-db.org/network/9606.ENSP00000495705Long intergenic non-protein coding RNA 2203.
ACBD6 protein networkhttps://string-db.org/network/9606.ENSP00000495710Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very wea [...]
ENSP00000495715 protein networkhttps://string-db.org/network/9606.ENSP00000495715Uncharacterized protein.
POU4F3 protein networkhttps://string-db.org/network/9606.ENSP00000495718POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of [...]
IQSEC2 protein networkhttps://string-db.org/network/9606.ENSP00000495726IQ motif and SEC7 domain-containing protein 2; Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins.
GSS protein networkhttps://string-db.org/network/9606.ENSP00000495750Glutathione synthetase.
ABHD5 protein networkhttps://string-db.org/network/9606.ENSP000004957781-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions [...]
SPG7 protein networkhttps://string-db.org/network/9606.ENSP00000495795Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable f [...]
NDP protein networkhttps://string-db.org/network/9606.ENSP00000495811Norrin; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing [...]
DTD1 protein networkhttps://string-db.org/network/9606.ENSP00000495845D-aminoacyl-tRNA deacylase 1.
PJVK protein networkhttps://string-db.org/network/9606.ENSP00000495855Pejvakin; Essential in the activity of auditory pathway neurons.
TRPM7 protein networkhttps://string-db.org/network/9606.ENSP00000495860Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a cent [...]
SPTB protein networkhttps://string-db.org/network/9606.ENSP00000495909Spectrin beta chain, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cyto [...]
TMEM155 protein networkhttps://string-db.org/network/9606.ENSP00000495936Transmembrane protein 155.
SLC35E2A protein networkhttps://string-db.org/network/9606.ENSP00000495949Solute carrier family 35 member E2A; Putative transporter.
KITLG protein networkhttps://string-db.org/network/9606.ENSP00000495951Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, g [...]
MYO3A protein networkhttps://string-db.org/network/9606.ENSP00000495965Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an imp [...]
TBX4 protein networkhttps://string-db.org/network/9606.ENSP00000495986T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.
CTXN2 protein networkhttps://string-db.org/network/9606.ENSP00000495988Cortexin-2; Cortexin 2.
POU3F4 protein networkhttps://string-db.org/network/9606.ENSP00000495996POU domain, class 3, transcription factor 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature [...]
SYNGAP1 protein networkhttps://string-db.org/network/9606.ENSP00000496007Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in [...]
ABHD18 protein networkhttps://string-db.org/network/9606.ENSP00000496010Protein ABHD18; Abhydrolase domain containing 18; Belongs to the AB hydrolase superfamily.
H3Y1 protein networkhttps://string-db.org/network/9606.ENSP00000496014Histone H3.Y; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Histone H3.Y-containing nucleosomes accumulate around transcription start sites and have flex [...]
LRTOMT-2 protein networkhttps://string-db.org/network/9606.ENSP00000496019Leucine-rich repeat-containing protein 51.
POLR1C protein networkhttps://string-db.org/network/9606.ENSP00000496044DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common co [...]
SCN7A protein networkhttps://string-db.org/network/9606.ENSP00000496114Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...]
PRKCB protein networkhttps://string-db.org/network/9606.ENSP00000496129Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B [...]
CYP2D6 protein networkhttps://string-db.org/network/9606.ENSP00000496150Cytochrome P450 2D6; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a sub [...]
CFAP97D2 protein networkhttps://string-db.org/network/9606.ENSP00000496151Uncharacterized protein CFAP97D2; CFAP97 domain containing 2; Belongs to the CFAP97 family.
ENSP00000496158 protein networkhttps://string-db.org/network/9606.ENSP00000496158Uncharacterized protein.
ALDOA protein networkhttps://string-db.org/network/9606.ENSP00000496166Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bispho [...]
BCL11A protein networkhttps://string-db.org/network/9606.ENSP00000496168B-cell lymphoma/leukemia 11A; Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. Involved in brain devel [...]
SLC52A2 protein networkhttps://string-db.org/network/9606.ENSP00000496184Solute carrier family 52, riboflavin transporter, member 2; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemic [...]
ENSP00000496197 protein networkhttps://string-db.org/network/9606.ENSP00000496197Uncharacterized protein.
KIF25 protein networkhttps://string-db.org/network/9606.ENSP00000496229Kinesin-like protein KIF25; Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separatio [...]
SLC33A1 protein networkhttps://string-db.org/network/9606.ENSP00000496241Acetyl-coenzyme A transporter 1; Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
RPL11 protein networkhttps://string-db.org/network/9606.ENSP0000049625060S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RN [...]
EYA1 protein networkhttps://string-db.org/network/9606.ENSP00000496255Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that deph [...]
SGCE protein networkhttps://string-db.org/network/9606.ENSP00000496268Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
TRIM8 protein networkhttps://string-db.org/network/9606.ENSP00000496301E3 ubiquitin-protein ligase TRIM8; E3 ubiquitin-protein ligase which plays different roles in immune pathways. Participates in the activation of interferon-gamma signaling by promoting proteasoma [...]
SLC18A2 protein networkhttps://string-db.org/network/9606.ENSP00000496339Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, seroton [...]
TLR5 protein networkhttps://string-db.org/network/9606.ENSP00000496355Toll-like receptor 5; Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular m [...]
TRIOBP protein networkhttps://string-db.org/network/9606.ENSP00000496394TRIO and F-actin-binding protein; May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F- actin. The localized formati [...]
AVPR2 protein networkhttps://string-db.org/network/9606.ENSP00000496396Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs [...]
RDX protein networkhttps://string-db.org/network/9606.ENSP00000496414Radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
FOXF2 protein networkhttps://string-db.org/network/9606.ENSP00000496415Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 [...]
CD8B2 protein networkhttps://string-db.org/network/9606.ENSP00000496416T-cell surface glycoprotein CD8 beta-2 chain; Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediat [...]
TCEAL9 protein networkhttps://string-db.org/network/9606.ENSP00000496422Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily.
S1PR2 protein networkhttps://string-db.org/network/9606.ENSP00000496438Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types o [...]
PRDM7 protein networkhttps://string-db.org/network/9606.ENSP00000496449Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase.
ENSP00000496470 protein networkhttps://string-db.org/network/9606.ENSP00000496470GLOBIN domain-containing protein; Belongs to the globin family.
SEMA3E protein networkhttps://string-db.org/network/9606.ENSP00000496491Semaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promote [...]
TPM2 protein networkhttps://string-db.org/network/9606.ENSP00000496494Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate [...]
TRMU protein networkhttps://string-db.org/network/9606.ENSP00000496496Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation o [...]
OTOA protein networkhttps://string-db.org/network/9606.ENSP00000496564Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family.
SOCS1 protein networkhttps://string-db.org/network/9606.ENSP00000496577Suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of [...]
ESPN protein networkhttps://string-db.org/network/9606.ENSP00000496593Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechano [...]
PFKM protein networkhttps://string-db.org/network/9606.ENSP00000496597ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to [...]
CYP21A2 protein networkhttps://string-db.org/network/9606.ENSP00000496625Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
ATXN3 protein networkhttps://string-db.org/network/9606.ENSP00000496695Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long pol [...]
CHAMP1 protein networkhttps://string-db.org/network/9606.ENSP00000496699Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle [...]
TUBB8B protein networkhttps://string-db.org/network/9606.ENSP00000496713Tubulin beta 8B; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain ( [...]
SERAC1 protein networkhttps://string-db.org/network/9606.ENSP00000496731Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remode [...]
LZTR1 protein networkhttps://string-db.org/network/9606.ENSP00000496779Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRA [...]
COL9A3 protein networkhttps://string-db.org/network/9606.ENSP00000496793Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye.
AKR1C8P protein networkhttps://string-db.org/network/9606.ENSP00000496804Aldo-keto reductase family 1 member C8, pseudogene.
GET1 protein networkhttps://string-db.org/network/9606.ENSP00000496813Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family.
ENSP00000496817 protein networkhttps://string-db.org/network/9606.ENSP00000496817Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
ISG15 protein networkhttps://string-db.org/network/9606.ENSP00000496832Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its [...]
PNISR protein networkhttps://string-db.org/network/9606.ENSP00000496842Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family.
HLA-DOB protein networkhttps://string-db.org/network/9606.ENSP00000496848HLA class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifi [...]
LRP2 protein networkhttps://string-db.org/network/9606.ENSP00000496870Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Me [...]
ZMYM1 protein networkhttps://string-db.org/network/9606.ENSP00000496876Zinc finger MYM-type containing 1.
LOC112267897 protein networkhttps://string-db.org/network/9606.ENSP00000496883Uncharacterized protein.
MCTS2P protein networkhttps://string-db.org/network/9606.ENSP00000496921Malignant T-cell-amplified sequence; MCTS family member 2, pseudogene.
KCNN4 protein networkhttps://string-db.org/network/9606.ENSP00000496939Intermediate conductance calcium-activated potassium channel protein 4; Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membran [...]
JAGN1 protein networkhttps://string-db.org/network/9606.ENSP00000496942Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; [...]
MYO1C protein networkhttps://string-db.org/network/9606.ENSP00000496954Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...]
ITGAM protein networkhttps://string-db.org/network/9606.ENSP00000496959Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles [...]
LOC647264 protein networkhttps://string-db.org/network/9606.ENSP00000496978Uncharacterized protein.
ENSP00000496982 protein networkhttps://string-db.org/network/9606.ENSP00000496982Uncharacterized protein.
MRPL28 protein networkhttps://string-db.org/network/9606.ENSP00000497004Mitochondrial ribosomal protein L28.
MMAA protein networkhttps://string-db.org/network/9606.ENSP00000497008Methylmalonic aciduria type A protein, mitochondrial; GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondr [...]
C2orf91 protein networkhttps://string-db.org/network/9606.ENSP00000497028Uncharacterized protein C2orf91; Chromosome 2 putative open reading frame 91.
H3Y2 protein networkhttps://string-db.org/network/9606.ENSP00000497053Putative histone H3.X; Primate-specific variant histone H3, which constitutes a core component of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the c [...]
IGF1R protein networkhttps://string-db.org/network/9606.ENSP00000497069Insulin-like growth factor 1 receptor alpha chain; Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS [...]
FEZ1 protein networkhttps://string-db.org/network/9606.ENSP00000497070Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to re [...]
ENSP00000497072 protein networkhttps://string-db.org/network/9606.ENSP00000497072Hist_deacetyl domain-containing protein.
FAM90A7P protein networkhttps://string-db.org/network/9606.ENSP00000497076Putative protein FAM90A7P; Belongs to the FAM90 family.
CTLA4 protein networkhttps://string-db.org/network/9606.ENSP00000497102Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is consider [...]
SH3BP1 protein networkhttps://string-db.org/network/9606.ENSP00000497104SH3 domain-binding protein 1; GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically ina [...]
GRM6 protein networkhttps://string-db.org/network/9606.ENSP00000497110Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...]
HOXA13 protein networkhttps://string-db.org/network/9606.ENSP00000497112Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the [...]
ZNF684 protein networkhttps://string-db.org/network/9606.ENSP00000497154Zinc finger protein 684; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
EIF2B5 protein networkhttps://string-db.org/network/9606.ENSP00000497160Translation initiation factor eIF-2B subunit epsilon; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family.
NNAT protein networkhttps://string-db.org/network/9606.ENSP00000497164Neuronatin; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May fu [...]
DYNC2H1 protein networkhttps://string-db.org/network/9606.ENSP00000497174Cytoplasmic dynein 2 heavy chain 1; May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and [...]
GMCL2 protein networkhttps://string-db.org/network/9606.ENSP00000497178Germ cell-less protein-like 2; Possible function in spermatogenesis. Probable substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequen [...]
CCBE1 protein networkhttps://string-db.org/network/9606.ENSP00000497183Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis. Belongs to the CCBE1 fami [...]
TRIM16 protein networkhttps://string-db.org/network/9606.ENSP00000497185Tripartite motif-containing protein 16; E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays [...]
FOXL2 protein networkhttps://string-db.org/network/9606.ENSP00000497217Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Pr [...]
ITM2B protein networkhttps://string-db.org/network/9606.ENSP00000497221Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils [...]
PCMT1 protein networkhttps://string-db.org/network/9606.ENSP00000497225Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomp [...]
ENOSF1 protein networkhttps://string-db.org/network/9606.ENSP00000497230Mitochondrial enolase superfamily member 1; Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydr [...]
ALAS2 protein networkhttps://string-db.org/network/9606.ENSP000004972365-aminolevulinate synthase, erythroid-specific, mitochondrial; 5'-aminolevulinate synthase 2.
CRYBB1 protein networkhttps://string-db.org/network/9606.ENSP00000497249Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
KLHDC7B protein networkhttps://string-db.org/network/9606.ENSP00000497256Kelch domain containing 7B.
GNAI1 protein networkhttps://string-db.org/network/9606.ENSP00000497260Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous sig [...]
IFIH1 protein networkhttps://string-db.org/network/9606.ENSP00000497271Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and i [...]
ABCC2 protein networkhttps://string-db.org/network/9606.ENSP00000497274Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosid [...]
AGK protein networkhttps://string-db.org/network/9606.ENSP00000497280Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does [...]
CDH5 protein networkhttps://string-db.org/network/9606.ENSP00000497290Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus con [...]
LHB protein networkhttps://string-db.org/network/9606.ENSP00000497294Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
ENSP00000497305 protein networkhttps://string-db.org/network/9606.ENSP00000497305Ricin B-type lectin domain-containing protein.
ZDBF2 protein networkhttps://string-db.org/network/9606.ENSP00000497308DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2.
ALX3 protein networkhttps://string-db.org/network/9606.ENSP00000497310Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development.
CPOX protein networkhttps://string-db.org/network/9606.ENSP00000497326Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of copropo [...]
GAN protein networkhttps://string-db.org/network/9606.ENSP00000497351Gigaxonin; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein li [...]
CD53 protein networkhttps://string-db.org/network/9606.ENSP00000497382Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By s [...]
TRIM60 protein networkhttps://string-db.org/network/9606.ENSP00000497401Tripartite motif containing 60; Belongs to the TRIM/RBCC family.
RCC1 protein networkhttps://string-db.org/network/9606.ENSP00000497402Regulator of chromosome condensation; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nucl [...]
SETBP1 protein networkhttps://string-db.org/network/9606.ENSP00000497406SET binding protein 1.
BBS10 protein networkhttps://string-db.org/network/9606.ENSP00000497413Bardet-Biedl syndrome 10 protein; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis [...]
EIF4E1B protein networkhttps://string-db.org/network/9606.ENSP00000497422Eukaryotic translation initiation factor 4E type 1B; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates rib [...]
SLC35B1 protein networkhttps://string-db.org/network/9606.ENSP00000497423Solute carrier family 35 member B1; Probable sugar transporter; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
ENSP00000497443 protein networkhttps://string-db.org/network/9606.ENSP00000497443Uncharacterized protein.
LRPAP1 protein networkhttps://string-db.org/network/9606.ENSP00000497444Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. Belongs to th [...]
COX7B protein networkhttps://string-db.org/network/9606.ENSP00000497474Cytochrome c oxidase subunit 7B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The re [...]
MYT1L protein networkhttps://string-db.org/network/9606.ENSP00000497479Myelin transcription factor 1-like protein; Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differ [...]
RTL1 protein networkhttps://string-db.org/network/9606.ENSP00000497482Retrotransposon-like protein 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta.
DHH protein networkhttps://string-db.org/network/9606.ENSP00000497483Desert hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential fo [...]
ENSP00000497509 protein networkhttps://string-db.org/network/9606.ENSP00000497509Novel transcript.
MKKS-2 protein networkhttps://string-db.org/network/9606.ENSP00000497510McKusick-Kaufman syndrome, isoform CRA_a.
INPP5F protein networkhttps://string-db.org/network/9606.ENSP00000497527Phosphatidylinositide phosphatase SAC2; Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-b [...]
SLC25A38 protein networkhttps://string-db.org/network/9606.ENSP00000497532Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step [...]
PI16 protein networkhttps://string-db.org/network/9606.ENSP00000497550Peptidase inhibitor 16; May inhibit cardiomyocyte growth.
DARS2 protein networkhttps://string-db.org/network/9606.ENSP00000497569Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial.
GCLC protein networkhttps://string-db.org/network/9606.ENSP00000497574Glutamate-cysteine ligase catalytic subunit.
FOXP1-2 protein networkhttps://string-db.org/network/9606.ENSP00000497585Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specifi [...]
NDUFV1 protein networkhttps://string-db.org/network/9606.ENSP00000497587NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minima [...]
PTP4A1 protein networkhttps://string-db.org/network/9606.ENSP00000497588Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of diffe [...]
PNRC2 protein networkhttps://string-db.org/network/9606.ENSP00000497590Proline-rich nuclear receptor coactivator 2; Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting th [...]
UBE3A protein networkhttps://string-db.org/network/9606.ENSP00000497594Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several su [...]
INO80 protein networkhttps://string-db.org/network/9606.ENSP00000497609Chromatin-remodeling ATPase INO80; ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part o [...]
PRSS51 protein networkhttps://string-db.org/network/9606.ENSP00000497613Serine protease 51.
EIF4A3 protein networkhttps://string-db.org/network/9606.ENSP00000497641Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent mu [...]
LPL protein networkhttps://string-db.org/network/9606.ENSP00000497642Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an i [...]
FAM90A10P protein networkhttps://string-db.org/network/9606.ENSP00000497650Putative protein FAM90A10P; Belongs to the FAM90 family.
TMPRSS9 protein networkhttps://string-db.org/network/9606.ENSP00000497651Transmembrane protease serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC a [...]
COL17A1 protein networkhttps://string-db.org/network/9606.ENSP00000497653120 kDa linear IgA disease antigen; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.
COG8 protein networkhttps://string-db.org/network/9606.ENSP00000497669Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function.
CDC14C protein networkhttps://string-db.org/network/9606.ENSP00000497679Dual specificity protein phosphatase CDC14C; Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).
LMBRD1 protein networkhttps://string-db.org/network/9606.ENSP00000497690Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Belongs to the LIMR family. L [...]
APLP2 protein networkhttps://string-db.org/network/9606.ENSP00000497691Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signalin [...]
TRIM51GP protein networkhttps://string-db.org/network/9606.ENSP00000497716Tripartite motif-containing 51G, pseudogene.
MPIG6B protein networkhttps://string-db.org/network/9606.ENSP00000497720Megakaryocyte and platelet inhibitory receptor G6b; Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production. [...]
CDC42 protein networkhttps://string-db.org/network/9606.ENSP00000497733Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of e [...]
EDC3 protein networkhttps://string-db.org/network/9606.ENSP00000497737Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis an [...]
CTPS1 protein networkhttps://string-db.org/network/9606.ENSP00000497744CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or [...]
BMPER protein networkhttps://string-db.org/network/9606.ENSP00000497748BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
FOXC2 protein networkhttps://string-db.org/network/9606.ENSP00000497759Forkhead box protein C2; Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
ALDOB protein networkhttps://string-db.org/network/9606.ENSP00000497767Aldolase, fructose-bisphosphate B.
C2orf15 protein networkhttps://string-db.org/network/9606.ENSP00000497775Uncharacterized protein C2orf15; Chromosome 2 open reading frame 15.
EPB42 protein networkhttps://string-db.org/network/9606.ENSP00000497777Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties.
ALOX12B protein networkhttps://string-db.org/network/9606.ENSP00000497784Arachidonate 12-lipoxygenase, 12R-type; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipi [...]
DLG4 protein networkhttps://string-db.org/network/9606.ENSP00000497806Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. [...]
MAGEL2 protein networkhttps://string-db.org/network/9606.ENSP00000497810MAGE-like protein 2; Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-con [...]
AP5Z1 protein networkhttps://string-db.org/network/9606.ENSP00000497815AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to it is a putative helicase required for efficient hom [...]
CHRNE protein networkhttps://string-db.org/network/9606.ENSP00000497829Acetylcholine receptor subunit epsilon; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting c [...]
EDDM13 protein networkhttps://string-db.org/network/9606.ENSP00000497858Epididymal protein 13.
CCDC144NL protein networkhttps://string-db.org/network/9606.ENSP00000497867Putative coiled-coil domain-containing protein 144 N-terminal-like; CCDC144A N-terminal pseudogene; Belongs to the CCDC144 family.
ENSP00000497876 protein networkhttps://string-db.org/network/9606.ENSP00000497876Novel protein.
NACA-2 protein networkhttps://string-db.org/network/9606.ENSP00000497880Uncharacterized protein.
ATP8B1 protein networkhttps://string-db.org/network/9606.ENSP00000497896Phospholipid-transporting ATPase IC; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
B2M protein networkhttps://string-db.org/network/9606.ENSP00000497910Beta-2-microglobulin form pI 5.3; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tub [...]
IL21 protein networkhttps://string-db.org/network/9606.ENSP00000497915Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). M [...]
NDN protein networkhttps://string-db.org/network/9606.ENSP00000497916Necdin; Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-pr [...]
ABCB11 protein networkhttps://string-db.org/network/9606.ENSP00000497931Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more ra [...]
TTC37 protein networkhttps://string-db.org/network/9606.ENSP00000497948Tetratricopeptide repeat protein 37; Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner depe [...]
IL17A protein networkhttps://string-db.org/network/9606.ENSP00000497968Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells [...]
WRB-SH3BGR protein networkhttps://string-db.org/network/9606.ENSP00000497977Uncharacterized protein.
MALT1 protein networkhttps://string-db.org/network/9606.ENSP00000497997Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomeriz [...]
ENSP00000498010 protein networkhttps://string-db.org/network/9606.ENSP00000498010Uncharacterized protein.
RPS17 protein networkhttps://string-db.org/network/9606.ENSP00000498019Ribosomal protein S17.
DCLRE1B protein networkhttps://string-db.org/network/9606.ENSP000004980425' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-jo [...]
RAMACL protein networkhttps://string-db.org/network/9606.ENSP00000498060RNA guanine-7 methyltransferase-activating subunit-like (pseudogene); RNA guanine-7 methyltransferase activating subunit like.
CA5A protein networkhttps://string-db.org/network/9606.ENSP00000498065Carbonic anhydrase 5A, mitochondrial; Reversible hydration of carbon dioxide. Low activity.
CARD14 protein networkhttps://string-db.org/network/9606.ENSP00000498071Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms [...]
ENPP1 protein networkhttps://string-db.org/network/9606.ENSP00000498074Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue c [...]
MKNK1 protein networkhttps://string-db.org/network/9606.ENSP00000498083MAP kinase-interacting serine/threonine-protein kinase 1; May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus inc [...]
H2AL1RP protein networkhttps://string-db.org/network/9606.ENSP00000498087H2A.L variant histone R, pseudogene.
BCL10 protein networkhttps://string-db.org/network/9606.ENSP00000498104B-cell lymphoma/leukemia 10; Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between up [...]
DLX5 protein networkhttps://string-db.org/network/9606.ENSP00000498116Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulat [...]
ENSP00000498126 protein networkhttps://string-db.org/network/9606.ENSP00000498126Novel protein.
CAPN5 protein networkhttps://string-db.org/network/9606.ENSP00000498132Calpain-5; Calcium-regulated non-lysosomal thiol-protease.
CCDC186 protein networkhttps://string-db.org/network/9606.ENSP00000498136Coiled-coil domain containing 186.
TPRA1 protein networkhttps://string-db.org/network/9606.ENSP00000498161Transmembrane protein adipocyte associated 1; Belongs to the UPF0359 family.
HESX1 protein networkhttps://string-db.org/network/9606.ENSP00000498190Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcripti [...]
KCNK9 protein networkhttps://string-db.org/network/9606.ENSP00000498198Potassium channel subfamily K member 9; pH-dependent, voltage-insensitive, background potassium channel protein.
FANCB protein networkhttps://string-db.org/network/9606.ENSP00000498215Fanconi anemia group B protein; DNA repair protein required for FANCD2 ubiquitination.
ALX4 protein networkhttps://string-db.org/network/9606.ENSP00000498217Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development; Belongs t [...]
SELL protein networkhttps://string-db.org/network/9606.ENSP00000498227L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial v [...]
PLAAT1 protein networkhttps://string-db.org/network/9606.ENSP00000498228Phospholipase A and acyltransferase 1; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent re [...]
INKA1 protein networkhttps://string-db.org/network/9606.ENSP00000498241PAK4-inhibitor INKA1; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.
ABCG2 protein networkhttps://string-db.org/network/9606.ENSP00000498246Broad substrate specificity ATP-binding cassette transporter ABCG2; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide va [...]
MTUS2 protein networkhttps://string-db.org/network/9606.ENSP00000498251Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynam [...]
UBE2W protein networkhttps://string-db.org/network/9606.ENSP00000498255Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrat [...]
GPR55 protein networkhttps://string-db.org/network/9606.ENSP00000498258G-protein coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha- lysophosphatidylinositol (LPI). LPI induces [...]
ACSL6 protein networkhttps://string-db.org/network/9606.ENSP00000498260Long-chain-fatty-acid--CoA ligase 6; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Pl [...]
DCAKD protein networkhttps://string-db.org/network/9606.ENSP00000498268dephospho-CoA kinase domain containing.
BSND protein networkhttps://string-db.org/network/9606.ENSP00000498282Barttin; Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stri [...]
MYD88 protein networkhttps://string-db.org/network/9606.ENSP00000498321Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 [...]
LHFPL5 protein networkhttps://string-db.org/network/9606.ENSP00000498322LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Reg [...]
PPP3R2 protein networkhttps://string-db.org/network/9606.ENSP00000498330Calcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
MTHFD1 protein networkhttps://string-db.org/network/9606.ENSP00000498336C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; bel [...]
FECH protein networkhttps://string-db.org/network/9606.ENSP00000498358Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.
PQBP1 protein networkhttps://string-db.org/network/9606.ENSP00000498362Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innat [...]
ALPK1 protein networkhttps://string-db.org/network/9606.ENSP00000498374Alpha-protein kinase 1; Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step f [...]
DEPDC5 protein networkhttps://string-db.org/network/9606.ENSP00000498382GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydro [...]
KYAT1-2 protein networkhttps://string-db.org/network/9606.ENSP00000498386Kynurenine--oxoglutarate transaminase 1.
ENSP00000498395 protein networkhttps://string-db.org/network/9606.ENSP00000498395Novel protein.
SUMF2 protein networkhttps://string-db.org/network/9606.ENSP00000498402Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activ [...]
ENSP00000498408 protein networkhttps://string-db.org/network/9606.ENSP00000498408Uncharacterized protein.
ZNF844-2 protein networkhttps://string-db.org/network/9606.ENSP00000498410Zinc finger protein 844.
CYP26C1 protein networkhttps://string-db.org/network/9606.ENSP00000498424Cytochrome P450 26C1; Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate); Belongs to the cytoc [...]
ZFP41 protein networkhttps://string-db.org/network/9606.ENSP00000498437ZFP41 zinc finger protein.
FGA protein networkhttps://string-db.org/network/9606.ENSP00000498441Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fi [...]
FAS protein networkhttps://string-db.org/network/9606.ENSP00000498466Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling comp [...]
C12orf76 protein networkhttps://string-db.org/network/9606.ENSP00000498468Uncharacterized protein C12orf76; Chromosome 12 open reading frame 76.
POLR3G protein networkhttps://string-db.org/network/9606.ENSP00000498469DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...]
MAP1LC3B protein networkhttps://string-db.org/network/9606.ENSP00000498476Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to reg [...]
SH2D6 protein networkhttps://string-db.org/network/9606.ENSP00000498488SH2 domain containing 6.
ZNF487 protein networkhttps://string-db.org/network/9606.ENSP00000498490Putative zinc finger protein 487; May be involved in transcriptional regulation.
SPDYE14 protein networkhttps://string-db.org/network/9606.ENSP00000498497Uncharacterized protein.
CTC1 protein networkhttps://string-db.org/network/9606.ENSP00000498499CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...]
SPDYE11 protein networkhttps://string-db.org/network/9606.ENSP00000498510speedy/RINGO cell cycle regulator family member E11; Belongs to the Speedy/Ringo family.
ADAM20 protein networkhttps://string-db.org/network/9606.ENSP00000498512Disintegrin and metalloproteinase domain-containing protein 20; May be involved in sperm maturation and/or fertilization.
ENSP00000498524 protein networkhttps://string-db.org/network/9606.ENSP00000498524EXPERA domain-containing protein.
LRRC55 protein networkhttps://string-db.org/network/9606.ENSP00000498533Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...]
ZDHHC23 protein networkhttps://string-db.org/network/9606.ENSP00000498556Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeti [...]
NFE4 protein networkhttps://string-db.org/network/9606.ENSP00000498569Transcription factor NF-E4; Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by [...]
TPM3 protein networkhttps://string-db.org/network/9606.ENSP00000498577Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebra [...]
NOTCH1 protein networkhttps://string-db.org/network/9606.ENSP00000498587Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand a [...]
ZNF266 protein networkhttps://string-db.org/network/9606.ENSP00000498589Zinc finger protein 266; May be involved in transcriptional regulation.
STING1 protein networkhttps://string-db.org/network/9606.ENSP00000498596Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (I [...]
ELMO3 protein networkhttps://string-db.org/network/9606.ENSP00000498602Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...]
WDR26 protein networkhttps://string-db.org/network/9606.ENSP00000498603WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G [...]
SLC29A1 protein networkhttps://string-db.org/network/9606.ENSP00000498610Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor [...]
ANKRD36 protein networkhttps://string-db.org/network/9606.ENSP00000498611Ankyrin repeat domain-containing protein 36A; Ankyrin repeat domain 36.
MYT1 protein networkhttps://string-db.org/network/9606.ENSP00000498616Myelin transcription factor 1; Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia [...]
MIP protein networkhttps://string-db.org/network/9606.ENSP00000498622Lens fiber major intrinsic protein; Water channel. Channel activity is down- regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of th [...]
ZFHX4 protein networkhttps://string-db.org/network/9606.ENSP00000498627Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.
IL31RA protein networkhttps://string-db.org/network/9606.ENSP00000498630Interleukin-31 receptor subunit alpha; Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediate [...]
ARMCX5-GPRASP2 protein networkhttps://string-db.org/network/9606.ENSP00000498643ARMCX5-GPRASP2 readthrough.
DEK protein networkhttps://string-db.org/network/9606.ENSP00000498653Protein DEK; Involved in chromatin organization.
PWWP3A protein networkhttps://string-db.org/network/9606.ENSP00000498656PWWP domain-containing DNA repair factor 3A; Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by T [...]
B3GALNT1 protein networkhttps://string-db.org/network/9606.ENSP00000498660UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development (By simil [...]
LRRC4B protein networkhttps://string-db.org/network/9606.ENSP00000498662Leucine-rich repeat-containing protein 4B; Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation [...]
MYCBPAP protein networkhttps://string-db.org/network/9606.ENSP00000498665MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity).
MRTFA protein networkhttps://string-db.org/network/9606.ENSP00000498671Myocardin-related transcription factor A; Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoske [...]
FHL1 protein networkhttps://string-db.org/network/9606.ENSP00000498684Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy.
SPEGNB protein networkhttps://string-db.org/network/9606.ENSP00000498687SPEG neighbor.
CPAMD8 protein networkhttps://string-db.org/network/9606.ENSP00000498697C3 and PZP like alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.
BICD1 protein networkhttps://string-db.org/network/9606.ENSP00000498700Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex.
GPR68 protein networkhttps://string-db.org/network/9606.ENSP00000498702Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. M [...]
RDH8 protein networkhttps://string-db.org/network/9606.ENSP00000498711Retinol dehydrogenase 8; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high lig [...]
INTS14 protein networkhttps://string-db.org/network/9606.ENSP00000498715Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent proce [...]
PRKY protein networkhttps://string-db.org/network/9606.ENSP00000498737Putative serine/threonine-protein kinase PRKY; Protein kinase Y-linked; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
GREM1 protein networkhttps://string-db.org/network/9606.ENSP00000498748Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining [...]
CCNH protein networkhttps://string-db.org/network/9606.ENSP00000498750Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphoryl [...]
CHRNG protein networkhttps://string-db.org/network/9606.ENSP00000498757Acetylcholine receptor subunit gamma; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...]
DSPP protein networkhttps://string-db.org/network/9606.ENSP00000498766Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regula [...]
SMIM11A protein networkhttps://string-db.org/network/9606.ENSP00000498771Small integral membrane protein 11A.
CLN5 protein networkhttps://string-db.org/network/9606.ENSP00000498772Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golg [...]
NBPF19 protein networkhttps://string-db.org/network/9606.ENSP00000498781NBPF member 19.
MCM8-2 protein networkhttps://string-db.org/network/9606.ENSP00000498784MCM domain-containing protein; Belongs to the MCM family.
HMBS protein networkhttps://string-db.org/network/9606.ENSP00000498786Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family.
MED19 protein networkhttps://string-db.org/network/9606.ENSP00000498791Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...]
LOC112577516 protein networkhttps://string-db.org/network/9606.ENSP00000498797CUB domain-containing protein.
ENSP00000498801 protein networkhttps://string-db.org/network/9606.ENSP00000498801Novel speedy/RINGO cell cycle regulator family member.
KRI1 protein networkhttps://string-db.org/network/9606.ENSP00000498803KRI1 homolog; Belongs to the KRI1 family.
BIN2 protein networkhttps://string-db.org/network/9606.ENSP00000498807Bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulat [...]
SPDYE8P protein networkhttps://string-db.org/network/9606.ENSP00000498819speedy/RINGO cell cycle regulator family member E8, pseudogene.
SPN protein networkhttps://string-db.org/network/9606.ENSP00000498852CD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and [...]
NIF3L1 protein networkhttps://string-db.org/network/9606.ENSP00000498853NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
CAPS protein networkhttps://string-db.org/network/9606.ENSP00000498855Calcyphosin; Calcium-binding protein. May play a role in cellular signaling events (Potential).
SPATA31A1 protein networkhttps://string-db.org/network/9606.ENSP00000498856Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis; Belongs to the SPATA31 family.
PDK3 protein networkhttps://string-db.org/network/9606.ENSP00000498864[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose [...]
LARS2 protein networkhttps://string-db.org/network/9606.ENSP00000498867Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial.
SNX6 protein networkhttps://string-db.org/network/9606.ENSP00000498872Sorting nexin-6, N-terminally processed; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bi [...]
ZC3H11B protein networkhttps://string-db.org/network/9606.ENSP00000498875Zinc finger CCCH domain-containing protein 11B; May play a role in mRNA transport.
CD59 protein networkhttps://string-db.org/network/9606.ENSP00000498879CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation [...]
ERCC5 protein networkhttps://string-db.org/network/9606.ENSP00000498881DNA repair protein complementing XP-G cells; Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Act [...]
PANK4 protein networkhttps://string-db.org/network/9606.ENSP000004988884'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels (Probable). The phosphatase activity shows preference for normal or oxi [...]
CRYBB2 protein networkhttps://string-db.org/network/9606.ENSP00000498905Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family.
GPRASP1 protein networkhttps://string-db.org/network/9606.ENSP00000498934G-protein coupled receptor-associated sorting protein 1; Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation [...]
CYP3A4 protein networkhttps://string-db.org/network/9606.ENSP00000498939Cytochrome P450 3A4; A cytochrome P450 monooxygenase involved in the metabolism of sterols, steroid hormones, retinoids and fatty acids. Mechanistically, uses molecular oxygen inserting one oxyge [...]
SPDYE9P protein networkhttps://string-db.org/network/9606.ENSP00000498945speedy/RINGO cell cycle regulator family member E9, pseudogene.
GPR101 protein networkhttps://string-db.org/network/9606.ENSP00000498972Probable G-protein coupled receptor 101; Orphan receptor.
GPR19 protein networkhttps://string-db.org/network/9606.ENSP00000498976Probable G-protein coupled receptor 19; Orphan receptor.
LOC114841035 protein networkhttps://string-db.org/network/9606.ENSP00000498991Uncharacterized protein LOC114841035.
PC protein networkhttps://string-db.org/network/9606.ENSP00000498994Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transf [...]
PRR26 protein networkhttps://string-db.org/network/9606.ENSP00000498998Proline-rich protein 26.
FBXW8 protein networkhttps://string-db.org/network/9606.ENSP00000498999F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of [...]
ESYT2 protein networkhttps://string-db.org/network/9606.ENSP00000499020Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glyceroph [...]
FAM161B protein networkhttps://string-db.org/network/9606.ENSP00000499021FAM161 centrosomal protein B; Belongs to the FAM161 family.
CBLB protein networkhttps://string-db.org/network/9606.ENSP00000499037E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their de [...]
RPS27 protein networkhttps://string-db.org/network/9606.ENSP0000049904440S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs ; Belongs to the eukaryotic ribosomal protein eS27 family.
DIABLO protein networkhttps://string-db.org/network/9606.ENSP00000499058Diablo IAP-binding mitochondrial protein.
EIF3L protein networkhttps://string-db.org/network/9606.ENSP00000499067Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...]
FAM219A protein networkhttps://string-db.org/network/9606.ENSP00000499069Protein FAM219A; Family with sequence similarity 219 member A.
IVD protein networkhttps://string-db.org/network/9606.ENSP00000499074Isovaleryl-CoA dehydrogenase, mitochondrial; isovaleryl-CoA dehydrogenase.
PREP protein networkhttps://string-db.org/network/9606.ENSP00000499089Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family.
GPRC5C protein networkhttps://string-db.org/network/9606.ENSP00000499092G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling [...]
NR1H2 protein networkhttps://string-db.org/network/9606.ENSP00000499121Oxysterols receptor LXR-beta; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having [...]
MS4A4E protein networkhttps://string-db.org/network/9606.ENSP00000499123Putative membrane-spanning 4-domains subfamily A member 4E; Membrane spanning 4-domains A4E; Belongs to the MS4A family.
PDIA4 protein networkhttps://string-db.org/network/9606.ENSP00000499129Protein disulfide-isomerase A4; Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family.
ZNF394 protein networkhttps://string-db.org/network/9606.ENSP00000499131Zinc finger protein 394; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
CES2 protein networkhttps://string-db.org/network/9606.ENSP00000499140Cocaine esterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl [...]
CLEC3A protein networkhttps://string-db.org/network/9606.ENSP00000499168C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin.
TMEM217-2 protein networkhttps://string-db.org/network/9606.ENSP00000499172Transmembrane protein 217.
ENC1 protein networkhttps://string-db.org/network/9606.ENSP00000499185Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down- regulates transcription factor [...]
TSPY9P protein networkhttps://string-db.org/network/9606.ENSP00000499192Testis-specific Y-encoded protein 4; Testis specific protein Y-linked 9, pseudogene.
SCLY protein networkhttps://string-db.org/network/9606.ENSP00000499199Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
ENSP00000499200 protein networkhttps://string-db.org/network/9606.ENSP00000499200Novel speedy/RINGO cell cycle regulator family member.
BLACAT1 protein networkhttps://string-db.org/network/9606.ENSP00000499205Bladder cancer associated transcript 1.
CARD8 protein networkhttps://string-db.org/network/9606.ENSP00000499211Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcripti [...]
ARHGAP9 protein networkhttps://string-db.org/network/9606.ENSP00000499232Rho GTPase-activating protein 9; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward [...]
NUSAP1 protein networkhttps://string-db.org/network/9606.ENSP00000499238Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the o [...]
SLMAP protein networkhttps://string-db.org/network/9606.ENSP00000499241Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; Belongs to the SLMAP family.
C11orf45 protein networkhttps://string-db.org/network/9606.ENSP00000499245Putative uncharacterized protein C11orf45; Chromosome 11 open reading frame 45.
NUAK2 protein networkhttps://string-db.org/network/9606.ENSP00000499251NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induce [...]
S100A2 protein networkhttps://string-db.org/network/9606.ENSP00000499289Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and in [...]
KCNJ8 protein networkhttps://string-db.org/network/9606.ENSP00000499300ATP-sensitive inward rectifier potassium channel 8; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potass [...]
ERCC6L2 protein networkhttps://string-db.org/network/9606.ENSP00000499371DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response.
JAKMIP3 protein networkhttps://string-db.org/network/9606.ENSP00000499375Janus kinase and microtubule interacting protein 3; Belongs to the JAKMIP family.
SDF4 protein networkhttps://string-db.org/network/9606.ENSP0000049938745 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family.
MYL3 protein networkhttps://string-db.org/network/9606.ENSP00000499406Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium.
CUTA protein networkhttps://string-db.org/network/9606.ENSP00000499422Protein CutA; May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE); Belongs to the CutA family.
FOXO3B protein networkhttps://string-db.org/network/9606.ENSP00000499455Forkhead box O3B.
IL19 protein networkhttps://string-db.org/network/9606.ENSP00000499459Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
AMPD2 protein networkhttps://string-db.org/network/9606.ENSP00000499465AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.
PIN4 protein networkhttps://string-db.org/network/9606.ENSP00000499466Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double- stran [...]
ENSP00000499467 protein networkhttps://string-db.org/network/9606.ENSP00000499467Fe2OG dioxygenase domain-containing protein.
H3-2 protein networkhttps://string-db.org/network/9606.ENSP00000499501H3.2 histone.
ENSP00000499503 protein networkhttps://string-db.org/network/9606.ENSP00000499503Novel protein.
FBXW4 protein networkhttps://string-db.org/network/9606.ENSP00000499522F-box/WD repeat-containing protein 4; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathw [...]
NINJ2 protein networkhttps://string-db.org/network/9606.ENSP00000499548Ninjurin-2; Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.
SCN11A protein networkhttps://string-db.org/network/9606.ENSP00000499569Sodium channel protein type 11 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to th [...]
MANF protein networkhttps://string-db.org/network/9606.ENSP00000499582Mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neuro [...]
TNNT2 protein networkhttps://string-db.org/network/9606.ENSP00000499593Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase [...]
ARHGEF18-2 protein networkhttps://string-db.org/network/9606.ENSP00000499655Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, [...]
ANKRD30B protein networkhttps://string-db.org/network/9606.ENSP00000499676Ankyrin repeat domain 30B.
SFTPB protein networkhttps://string-db.org/network/9606.ENSP00000499683Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air sp [...]
UCP2 protein networkhttps://string-db.org/network/9606.ENSP00000499695Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP [...]
CALM1 protein networkhttps://string-db.org/network/9606.ENSP00000499717Calmodulin-1; Calmodulin 1; Belongs to the calmodulin family.
ENSP00000499734 protein networkhttps://string-db.org/network/9606.ENSP00000499734Uncharacterized protein.
SOCS7 protein networkhttps://string-db.org/network/9606.ENSP00000499750Suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 [...]
ASB3 protein networkhttps://string-db.org/network/9606.ENSP00000499751Ankyrin repeat and SOCS box protein 3; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...]
ITCH protein networkhttps://string-db.org/network/9606.ENSP00000499786E3 ubiquitin-protein ligase Itchy homolog; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly tran [...]
PRYP3 protein networkhttps://string-db.org/network/9606.ENSP00000499795PTPN13 like Y-linked pseudogene 3.
CALM2 protein networkhttps://string-db.org/network/9606.ENSP00000499797Calmodulin 2.
YI018_HUMAN protein networkhttps://string-db.org/network/9606.ENSP00000499803Uncharacterized protein FLJ76381.
CNK3/IPCEF1 protein networkhttps://string-db.org/network/9606.ENSP00000499846CNK3/IPCEF1 fusion protein; Required for hepatocyte growth factor (HGF)-dependent activation of Arf6 and HGF-stimulated cell migration.
ATP5MC2 protein networkhttps://string-db.org/network/9606.ENSP00000499883ATP synthase F(0) complex subunit C2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...]
JAK1 protein networkhttps://string-db.org/network/9606.ENSP00000499900Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interle [...]
AK2 protein networkhttps://string-db.org/network/9606.ENSP00000499935Adenylate kinase 2, mitochondrial, N-terminally processed; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeos [...]
LINC01862 protein networkhttps://string-db.org/network/9606.ENSP00000499970Long intergenic non-protein coding RNA 1862.
ATP8B2 protein networkhttps://string-db.org/network/9606.ENSP00000500034Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...]
ATAD3B protein networkhttps://string-db.org/network/9606.ENSP00000500094ATPase family AAA domain-containing protein 3B; May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies [...]
BTD protein networkhttps://string-db.org/network/9606.ENSP00000500193Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
ARSL protein networkhttps://string-db.org/network/9606.ENSP00000500220Arylsulfatase L; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.
DPEP3 protein networkhttps://string-db.org/network/9606.ENSP00000500237Dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 [...]
SLC25A52 protein networkhttps://string-db.org/network/9606.ENSP00000500333Solute carrier family 25 member 52.
ENSP00000500339 protein networkhttps://string-db.org/network/9606.ENSP00000500339Uncharacterized protein.
AGAP6 protein networkhttps://string-db.org/network/9606.ENSP00000500374Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Belongs to the centaurin gamma-like family.
CAMK2A protein networkhttps://string-db.org/network/9606.ENSP00000500386Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, [...]
ARHGAP35 protein networkhttps://string-db.org/network/9606.ENSP00000500409Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhi [...]
SAMD8 protein networkhttps://string-db.org/network/9606.ENSP00000500411Sphingomyelin synthase-related protein 1; Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endopl [...]
HHLA1 protein networkhttps://string-db.org/network/9606.ENSP00000500443HERV-H LTR-associating 1.
AKT3 protein networkhttps://string-db.org/network/9606.ENSP00000500582RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includi [...]
OTX2 protein networkhttps://string-db.org/network/9606.ENSP00000500595Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'.
ETNK1 protein networkhttps://string-db.org/network/9606.ENSP00000500633Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis.
AP1S2 protein networkhttps://string-db.org/network/9606.ENSP00000500695AP-1 complex subunit sigma-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...]
MUTYH protein networkhttps://string-db.org/network/9606.ENSP00000500891Adenine DNA glycosylase; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adeni [...]
MFSD4B protein networkhttps://string-db.org/network/9606.ENSP00000500934Sodium-dependent glucose transporter 1; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. Belongs to the major facilitator superf [...]
C2orf66 protein networkhttps://string-db.org/network/9606.ENSP00000500939Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66.
DDHD1 protein networkhttps://string-db.org/network/9606.ENSP00000500986Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity. Required for the or [...]
SNCA protein networkhttps://string-db.org/network/9606.ENSP00000500990Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monom [...]
ZBTB3 protein networkhttps://string-db.org/network/9606.ENSP00000501025Zinc finger and BTB domain-containing protein 3; May be involved in transcriptional regulation.
DUS4L-BCAP29 protein networkhttps://string-db.org/network/9606.ENSP00000501026DUS4L-BCAP29 readthrough.
SPDYE17 protein networkhttps://string-db.org/network/9606.ENSP00000501047Putative speedy protein E16; speedy/RINGO cell cycle regulator family member E17.
ADCY7 protein networkhttps://string-db.org/network/9606.ENSP00000501053Adenylate cyclase type 7; Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sph [...]
CCDC180 protein networkhttps://string-db.org/network/9606.ENSP00000501085Coiled-coil domain containing 180.
CFAP298-TCP10L protein networkhttps://string-db.org/network/9606.ENSP00000501088Uncharacterized protein.
TFAP2A protein networkhttps://string-db.org/network/9606.ENSP00000501092Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...]
GKN1 protein networkhttps://string-db.org/network/9606.ENSP00000501093Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
CEL protein networkhttps://string-db.org/network/9606.ENSP00000501111Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters [...]
URM1 protein networkhttps://string-db.org/network/9606.ENSP00000501135Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in [...]
C10orf67 protein networkhttps://string-db.org/network/9606.ENSP00000501139Uncharacterized protein C10orf67, mitochondrial; Chromosome 10 open reading frame 67.
HNF4G protein networkhttps://string-db.org/network/9606.ENSP00000501146Hepatocyte nuclear factor 4-gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha; Belongs to the nuclear hormone receptor family. NR2 subfamily.
PIK3CB protein networkhttps://string-db.org/network/9606.ENSP00000501150Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4 [...]
MAS1 protein networkhttps://string-db.org/network/9606.ENSP00000501180Proto-oncogene Mas; Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor le [...]
SPATS1 protein networkhttps://string-db.org/network/9606.ENSP00000501191Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1.
TCP11 protein networkhttps://string-db.org/network/9606.ENSP00000501201T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization- promoting peptide (FPP) at the sperm memb [...]
CD1D protein networkhttps://string-db.org/network/9606.ENSP00000501245Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells.
ALDH3B2 protein networkhttps://string-db.org/network/9606.ENSP00000501254Aldehyde dehydrogenase family 3 member B2; Oxidizes medium and long chain aldehydes into non-toxic fatty acids; Belongs to the aldehyde dehydrogenase family.
FAM163B protein networkhttps://string-db.org/network/9606.ENSP00000501259Protein FAM163B; Family with sequence similarity 163 member B; Belongs to the FAM163 family.
NWD1 protein networkhttps://string-db.org/network/9606.ENSP00000501265NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels.
LDB1 protein networkhttps://string-db.org/network/9606.ENSP00000501277LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by de [...]
RFX7 protein networkhttps://string-db.org/network/9606.ENSP00000501317DNA-binding protein RFX7; Regulatory factor X7; Belongs to the RFX family.