Organism Overview: Mycobacterium tuberculosis H37Rv


 
dnaA protein networkhttps://string-db.org/network/83332.Rv0001Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically doub [...]
dnaN protein networkhttps://string-db.org/network/83332.Rv0002DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reac [...]
recF protein networkhttps://string-db.org/network/83332.Rv0003DNA replication and repair protein RecF (single-strand DNA binding protein); The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF b [...]
Rv0004 protein networkhttps://string-db.org/network/83332.Rv0004Rv0004, (MTCY10H4.02), len: 187 aa. Conserved hypothetical protein (see Salazar et al., 1996). Belongs to superfamily DUF721; this family contains several actinomycete proteins of unknown functio [...]
gyrB protein networkhttps://string-db.org/network/83332.Rv0005DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while [...]
gyrA protein networkhttps://string-db.org/network/83332.Rv0006DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state, while [...]
Rv0007 protein networkhttps://string-db.org/network/83332.Rv0007Rv0007, (MTCY10H4.05), len: 304 aa. Possible conserved membrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
cwsA protein networkhttps://string-db.org/network/83332.Rv0008cPossible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family.
ppiA protein networkhttps://string-db.org/network/83332.Rv0009Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (rotamase A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic [...]
Rv0010c protein networkhttps://string-db.org/network/83332.Rv0010cRv0010c, (MTCY10H4.10c), len: 141 aa. Probable conserved membrane protein. Belongs to superfamily DUF2581,conserved in the Actinomycetales. A core mycobacterial gene; conserved in mycobacterial s [...]
crgA protein networkhttps://string-db.org/network/83332.Rv0011cProbable conserved transmembrane protein; Involved in cell division. Plays an important role in septal peptidoglycan synthesis and cell shape morphogenesis. May facilitate the recruitment of the [...]
Rv0012 protein networkhttps://string-db.org/network/83332.Rv0012Rv0012, (MTCY10H4.12), len: 262 aa. Probable conserved membrane protein. Belongs to superfamily DUF881. Contains probable N-terminal signal sequence.
trpG protein networkhttps://string-db.org/network/83332.Rv0013Possible anthranilate synthase component II TrpG (glutamine amidotransferase); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the [...]
pknB protein networkhttps://string-db.org/network/83332.Rv0014cTransmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and s [...]
pknA protein networkhttps://string-db.org/network/83332.Rv0015cTransmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and s [...]
pbpA protein networkhttps://string-db.org/network/83332.Rv0016cProbable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpept [...]
rodA protein networkhttps://string-db.org/network/83332.Rv0017cProbable cell division protein RodA; Rv0017c, (MTCY10H4.17c), len: 469 aa. Probable rodA (alternate gene name: ftsW), cell division protein,integral membrane protein. Belongs to the FTSW/RODA/SPO [...]
pstP protein networkhttps://string-db.org/network/83332.Rv0018cPhosphoserine/threonine phosphatase PstP; The only predicted protein phosphatase in M.tuberculosis, it dephosphorylates at least 5 protein kinases (PknA, PknB, PknD, PknE and PknF) and the penici [...]
fhaB protein networkhttps://string-db.org/network/83332.Rv0019cConserved protein with FHA domain, FhaB; Regulates growth and cell division. Probably required for divisomal protein assembly under oxidative stress.
fhaA protein networkhttps://string-db.org/network/83332.Rv0020cConserved protein with FHA domain, FhaA; Regulates cell growth and peptidoglycan synthesis by binding to MviN. May inhibit the late stages of peptidoglycan synthesis.
Rv0021c protein networkhttps://string-db.org/network/83332.Rv0021cRv0021c, (MTCY10H4.21c), len: 322 aa. Conserved hypothetical protein, similar to various proteins.
whiB5 protein networkhttps://string-db.org/network/83332.Rv0022cProbable transcriptional regulatory protein WhiB-like WhiB5; A transcription factor that is probably redox-responsive. Probably plays a role in immunomodulation and reactivation after chronic inf [...]
Rv0023 protein networkhttps://string-db.org/network/83332.Rv0023Rv0023, (MTCY10H4.23), len: 256 aa. Possible transcriptional regulator. Contains probable helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69 SD).
Rv0024 protein networkhttps://string-db.org/network/83332.Rv0024Rv0024, (MTCY10H4.24), len: 281 aa. Putative secreted protein, p60 homologue, similar to many. Similar to Mycobacterium tuberculosis proteins Rv1477, Rv1478,Rv1566c, Rv2190c. Could belong to the [...]
Rv0025 protein networkhttps://string-db.org/network/83332.Rv0025Rv0025, (MTCY10H4.25), len: 120 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. Rv0739 (268 aa), FASTA score: (37.6% identity in [...]
Rv0026 protein networkhttps://string-db.org/network/83332.Rv0026Rv0026, (MTCY10H4.26), len: 448 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis: Rv0025 FASTA score: (35.4% identity in 113 aa overla [...]
Rv0027 protein networkhttps://string-db.org/network/83332.Rv0027Rv0027, (MTCY10H4.27), len: 105 aa. Conserved hypothetical unknown protein.
Rv0028 protein networkhttps://string-db.org/network/83332.Rv0028Rv0028, (MTCY10H4.28), len: 101 aa. Conserved hypothetical unknown protein.
Rv0029 protein networkhttps://string-db.org/network/83332.Rv0029Rv0029, (MTCY10H4.29), len: 365 aa. Conserved hypothetical protein, showing some similarity to other proteins from Mycobacterium tuberculosis e.g. C-terminal region of Rv2082; Rv3899c.
Rv0030 protein networkhttps://string-db.org/network/83332.Rv0030Rv0030, (MTCY10H4.30), len: 109 aa. Conserved hypothetical unknown protein.
Rv0031 protein networkhttps://string-db.org/network/83332.Rv0031Rv0031, (MTCY10H4.31), len: 70 aa. Possible remnant of a transposase, showing partial similarity to mycobacterial transposases in a short overlap, e.g. Rv2791c|MTV002_57 (459 aa), FASTA score: (7 [...]
bioF2 protein networkhttps://string-db.org/network/83332.Rv0032Putative 8-amino-7-oxononanoate synthase 2; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier pro [...]
acpA protein networkhttps://string-db.org/network/83332.Rv0033Probable acyl carrier protein AcpA (ACP); Rv0033, (MTCY10H4.33), len: 87 aa. Probable acpA (alternate gene name: acpP), acyl carrier protein, similar to others. Also similar to proteins of Mycoba [...]
Rv0034 protein networkhttps://string-db.org/network/83332.Rv0034Rv0034, (MTCY10H4.34), len: 131 aa. Conserved hypothetical protein, showing weak similarity to AE001980|AE001980_7 hypothetical protein from Deinococcus radiodurans (120 aa), FASTA scores: opt: 1 [...]
fadD34 protein networkhttps://string-db.org/network/83332.Rv0035Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv0035, (MTCY10H4.35), len: 562 aa. Probable fadD34,fatty-acid-CoA synthetase, similar to many.
Rv0036c protein networkhttps://string-db.org/network/83332.Rv0036cConserved protein; Rv0036c, (MTCY10H4.36c), len: 257 aa. Conserved protein, highly similar to CAB95889.1|AL359988 conserved hypothetical protein from Streptomyces (276 aa). Also some similarity t [...]
Rv0037c protein networkhttps://string-db.org/network/83332.Rv0037cRv0037c, (MTCY10H4.37c), len: 441 aa. Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of macrolide.
Rv0038 protein networkhttps://string-db.org/network/83332.Rv0038Conserved protein; Rv0038, (MTCY10H4.38), len: 202 aa. Conserved protein, similar to many; Belongs to the UPF0301 (AlgH) family.
Rv0039c protein networkhttps://string-db.org/network/83332.Rv0039cRv0039c, (MTCY21D4.02c, MTCY10H4.39c), len: 115 aa. Possible conserved transmembrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
mtc28 protein networkhttps://string-db.org/network/83332.Rv0040cRv0040c, (MTCY21D4.03c), len: 310 aa. Mtc28,secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). A core mycobacterial gene; conserved in myco [...]
leuS protein networkhttps://string-db.org/network/83332.Rv0041Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS); Rv0041, (MTCY21D4.04), len: 969 aa. Probable leucyl-tRNA synthetase, similar to many. Contains PS00178 Aminoacyl-transfer RNA [...]
Rv0042c protein networkhttps://string-db.org/network/83332.Rv0042cRv0042c, (MTCY21D4.05c), len: 208 aa. Possible transcriptional regulatory protein, MarR-family. Some similarity to Mycobacterium tuberculosis proteins Rv2327,Rv0880, and Rv1404.
Rv0043c protein networkhttps://string-db.org/network/83332.Rv0043cProbable transcriptional regulatory protein (probably GntR-family); Rv0043c, (MTCY21D4.06c), len: 244 aa. Probable transcriptional regulator, GntR family, similar to others.
Rv0044c protein networkhttps://string-db.org/network/83332.Rv0044cRv0044c, (MTCY21D4.07c), len: 264 aa. Possible oxidoreductase, highly similar to AAD32732.1|MmcI|AF127374| F420-dependent H4MPT reductase from Streptomyces lavendulae (264 aa). Also similar to My [...]
Rv0045c protein networkhttps://string-db.org/network/83332.Rv0045cPossible hydrolase; Rv0045c, (MTCY21D4.08c), len: 298 aa. Possible hydrolase, showing similarity with others. Also similar to Mycobacterium tuberculosis proteins Rv3473c, Rv1123c,Rv1938, Rv3617, [...]
ino1 protein networkhttps://string-db.org/network/83332.Rv0046cInositol-3-phosphate synthase; Catalyzes the conversion of glucose 6-phosphate to 1D-myo- inositol 3-phosphate; Belongs to the myo-inositol 1-phosphate synthase family.
Rv0047c protein networkhttps://string-db.org/network/83332.Rv0047cConserved protein; Rv0047c, (MTCY21D4.10c), len: 180 aa. Conserved protein, similar to many.
Rv0048c protein networkhttps://string-db.org/network/83332.Rv0048cPossible membrane protein; Rv0048c, MTCY21D4.11c, len: 289 aa. Possible membrane protein.
Rv0049 protein networkhttps://string-db.org/network/83332.Rv0049Rv0049, (MTCY21D4.12), len: 137 aa. Conserved hypothetical protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
ponA1 protein networkhttps://string-db.org/network/83332.Rv0050Penicillin-insensitive transglycosylase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-term [...]
Rv0051 protein networkhttps://string-db.org/network/83332.Rv0051Probable conserved transmembrane protein; Rv0051, (MTCY21D4.14), len:560 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian, 2003). Probable conserved tran [...]
Rv0052 protein networkhttps://string-db.org/network/83332.Rv0052Conserved protein; Rv0052, (MTCY21D4.15), len: 187 aa. Conserved protein, similar to others including Rv1930c from Mycobacterium tuberculosis (174 aa). May be a membrane protein.
rpsF protein networkhttps://string-db.org/network/83332.Rv005330S ribosomal protein S6 RpsF; Binds together with S18 to 16S ribosomal RNA.
ssb protein networkhttps://string-db.org/network/83332.Rv0054Rv0054, (MTCY21D4.17), len: 164 aa. ssb,single-strand binding protein (see Mizrahi & Andersen 1998), highly similar to others. Belongs to the SSB family.
rpsR1 protein networkhttps://string-db.org/network/83332.Rv005530S ribosomal protein S18-1 RpsR1; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial [...]
rplI protein networkhttps://string-db.org/network/83332.Rv005650S ribosomal protein L9 RplI; Binds to the 23S rRNA.
Rv0057 protein networkhttps://string-db.org/network/83332.Rv0057Hypothetical protein; Rv0057, (MTCY21D4.20), len: 173 aa. Hypothetical unknown protein.
dnaB protein networkhttps://string-db.org/network/83332.Rv0058Probable replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB su [...]
Rv0059 protein networkhttps://string-db.org/network/83332.Rv0059Hypothetical protein; Rv0059, (MTV030.02), len: 230 aa. Hypothetical unknown protein.
Rv0060 protein networkhttps://string-db.org/network/83332.Rv0060Rv0060, (MTV030.03), len: 352 aa. Conserved hypothetical protein.
Rv0061c protein networkhttps://string-db.org/network/83332.Rv0061cHypothetical protein; Rv0061c, len: 112 aa. Conserved hypothetical protein supported by RNA-seq data. Similar to MMAR_3839, 76% identity in 112 aa overlap. Replaces questionable ORF Rv0061 (MTV03 [...]
celA1 protein networkhttps://string-db.org/network/83332.Rv0062Glucanase; Rv0062, (MTV030.05), len: 380 aa. Possible celA1,cellulase, similar to many. Seems to belong to cellulase family B (family 6 of glycosyl hydrolases). Note that previously known as celA [...]
Rv0063 protein networkhttps://string-db.org/network/83332.Rv0063Rv0063, (MTV030.06), len: 479 aa. Possible oxidoreductase, similar to many. Similar to Mycobacterium tuberculosis proteins e.g. Rv3107c, Rv1257c, etc. Contains PS00862 Oxygen oxidoreductases cova [...]
Rv0064 protein networkhttps://string-db.org/network/83332.Rv0064Rv0064, (MTV030.07), len: 979 aa. Probable conserved transmembrane protein, similar to many. Contains probable coiled-coil domain from aa 948 to 976.
vapB1 protein networkhttps://string-db.org/network/83332.Rv0064APossible antitoxin VapB1; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC1.
vapC1 protein networkhttps://string-db.org/network/83332.Rv0065Possible toxin VapC1; Toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB1 (By similarity). Has ribonuclease activity.
icd2 protein networkhttps://string-db.org/network/83332.Rv0066cIsocitrate dehydrogenase [NADP]; Rv0066c, (MTV030.09c), len: 745 aa. Probable icd2,isocitrate dehydrogenase NADP-dependent. Belongs to the monomeric-type family of IDH. Note that in H37Rv, Rv0066 [...]
Rv0067c protein networkhttps://string-db.org/network/83332.Rv0067cPossible transcriptional regulatory protein (possibly TetR-family); Rv0067c, (MTV030.10c), len: 189 aa. Possible transcriptional regulator, highly similar to many. Contains probable helix-turn-he [...]
Rv0068 protein networkhttps://string-db.org/network/83332.Rv0068Rv0068, (MTV030.11), len: 303 aa. Probable oxidoreductase, similar to many; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
sdaA protein networkhttps://string-db.org/network/83332.Rv0069cRv0069c, (MTV030.12c), len: 461 aa. Probable sdaA,L-serine dehydratase. Belongs to the iron-sulfur dependent L-serine dehydratase family. Cofactor: iron-sulfur (4FE-4S) (probable).
glyA2 protein networkhttps://string-db.org/network/83332.Rv0070cSerine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. [...]
Rv0071 protein networkhttps://string-db.org/network/83332.Rv0071Possible maturase; Rv0071, (MTV030.14), len: 235 aa. Possible maturase,similar to many proteins of the group II intron maturase family. Contains 5 VDP repeats at N-terminus, these are also found [...]
Rv0072 protein networkhttps://string-db.org/network/83332.Rv0072Probable glutamine-transport transmembrane protein ABC transporter; Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (B [...]
Rv0073 protein networkhttps://string-db.org/network/83332.Rv0073Probable glutamine-transport ATP-binding protein ABC transporter; Probably part of an ABC transporter complex. Probably responsible for energy coupling to the transport system (By similarity).
Rv0074 protein networkhttps://string-db.org/network/83332.Rv0074Conserved protein; Rv0074, (MTV030.18), len: 411 aa. Conserved protein,similar to many.
Rv0075 protein networkhttps://string-db.org/network/83332.Rv0075Rv0075, (MTV030.19), len: 390 aa. Probable aminotransferase, similar to many class-II pyridoxal-phosphate-dependent aminotransferases (MALY/PATB subfamily). Also similar to other proteins from My [...]
Rv0076c protein networkhttps://string-db.org/network/83332.Rv0076cProbable membrane protein; Rv0076c, (MTV030.20c), len: 129 aa. Probable membrane protein, with membrane-spanning domain at C-terminus.
Rv0077c protein networkhttps://string-db.org/network/83332.Rv0077cProbable oxidoreductase; Rv0077c, (MTV030.21c), len: 276 aa. Possible oxidoreductase, weakly similar to others from Streptomyces. Also similar to MTCY05A6_35 and MTCY1A11_10 from Mycobacterium tu [...]
Rv0078 protein networkhttps://string-db.org/network/83332.Rv0078Rv0078, (MTV030.22), len: 201 aa. Probable transcriptional regulator. Contains probable helix-turn-helix motif from aa 35 to 56 (Score 1348, +3.78 SD).
Rv0078A protein networkhttps://string-db.org/network/83332.Rv0078ARv0078A, len: 197 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv0078B protein networkhttps://string-db.org/network/83332.Rv0078BRv0078B, len: 68 aa. Conserved protein.
Rv0079 protein networkhttps://string-db.org/network/83332.Rv0079Unknown protein; Involved in translation regulation. Inhibits protein synthesis and decreases bacterial growth when expressed in E.coli. Can also stimulate macrophages and peripheral blood mononu [...]
Rv0080 protein networkhttps://string-db.org/network/83332.Rv0080Rv0080, (MTV030.24), len: 152 aa. Conserved hypothetical protein. Belongs to pyridoxine 5'-phosphate (PNP) oxidase-like (PNPOx-like) superfamily.
Rv0081 protein networkhttps://string-db.org/network/83332.Rv0081Rv0081, (MTV030.25), len: 114 aa. Probable transcriptional regulator, highly similar to others.
Rv0082 protein networkhttps://string-db.org/network/83332.Rv0082Rv0082, (MTV030.26), len: 159 aa. Probable oxidoreductase, highly similar or similar to other various oxidoreductases. Nucleotide position 90144 in the genome sequence has been corrected, A:G res [...]
Rv0083 protein networkhttps://string-db.org/network/83332.Rv0083Probable oxidoreductase; Rv0083, (MTV030.27, MTCY251.01), len: 640 aa. Probable oxidoreductase, showing some similarity to other various oxidoreductases. Nucleotide position 91071 in the genome s [...]
hycD protein networkhttps://string-db.org/network/83332.Rv0084Possible formate hydrogenlyase HycD (FHL); Rv0084, (MTCY251.02), len: 316 aa. Possible hycD (alternate gene name: hevD), formate hydrogenlyase,integral membrane protein, similar to others. Belong [...]
hycP protein networkhttps://string-db.org/network/83332.Rv0085Rv0085, (MTCY251.03), len: 220 aa. Possible hycP,hydrogenase, integral membrane protein. Belongs to NADH-ubiquinone/plastoquinone oxidoreductase chain 4L superfamily.
hycQ protein networkhttps://string-db.org/network/83332.Rv0086Rv0086, (MTCY251.04), len: 488 aa. Possible hycQ,hydrogenase, integral membrane protein. Belongs to the NADH-Ubiquinone/plastoquinone (complex I) superfamily.
hycE protein networkhttps://string-db.org/network/83332.Rv0087Possible formate hydrogenase HycE (FHL); Rv0087, (MTCY251.05), len: 492 aa. Possible hycE (alternate gene name: hevE), formate hydrogenlyase, similar to others. Belongs to the complex I 49 kDa su [...]
Rv0088 protein networkhttps://string-db.org/network/83332.Rv0088Rv0088, (MTCY251.06), len: 224 aa. Possible polyketide cyclase/dehydrase. Belongs to the SRPBCC ligand-binding domain superfamily. Predicted to be an outer membrane protein (See Song et al., 2008 [...]
Rv0089 protein networkhttps://string-db.org/network/83332.Rv0089Rv0089, (MTCY251.07), len: 197 aa. Possible methyltransferase, showing some weak similarity to others. Also some similarity with many biotin biosynthesis proteins. Belongs to the methyltransferas [...]
Rv0090 protein networkhttps://string-db.org/network/83332.Rv0090Possible membrane protein; Rv0090, (MTCY251.08), len: 256 aa. Possible membrane protein. Contains IPR014511 Protein of unknown function DUF2068, transmembrane, subgroup.
mtn protein networkhttps://string-db.org/network/83332.Rv00915'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) [...]
ctpA protein networkhttps://string-db.org/network/83332.Rv0092Cation transporter P-type ATPase a CtpA; Involved in copper export. Could be involved in the copper detoxification of mycobacterial cells; Belongs to the cation transport ATPase (P-type) (TC 3.A. [...]
Rv0093c protein networkhttps://string-db.org/network/83332.Rv0093cRv0093c, (MTCY251.12c), len: 282 aa. Probable conserved membrane protein, equivalent only to CAC30943.1|AL583924 probable integral membrane protein from Mycobacterium leprae (237 aa). A core myco [...]
Rv0094c protein networkhttps://string-db.org/network/83332.Rv0094cConserved hypothetical protein; Rv0094c, (MTCY251.13c), len: 317 aa. Member of 13E12 repeat family, showing some similarity to U15187|MLU15187_7 from Mycobacterium leprae (94 aa), FASTA score: (4 [...]
Rv0095c protein networkhttps://string-db.org/network/83332.Rv0095cConserved hypothetical protein; Rv0095c, (MTCY251.14c), len: 136 aa. Member of 13E12 repeat, also partially similar to AF0418|AF041819_8 from Mycobacterium bovis BCG (222 aa), FASTA score: (89.6% [...]
PPE1 protein networkhttps://string-db.org/network/83332.Rv0096Rv0096, (MTCY251.15), len: 463 aa. PPE1, Member of the Mycobacterium tuberculosis PPE family, similar to many. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., [...]
Rv0097 protein networkhttps://string-db.org/network/83332.Rv0097Rv0097, (MTCY251.16), len: 289 aa. Possible oxidoreductase, equivalent to NP_302343.1|NC_002677 putative oxidoreductase from Mycobacterium leprae (289 aa). Also highly similar to BAB69377.1|AB070 [...]
fcoT protein networkhttps://string-db.org/network/83332.Rv0098Probable fatty acyl CoA thioesterase type III FcoT; Thiesterase that shows a preference for long chain fatty acyl groups. In vitro, cleaves the thioester linkage of palmitoyl-CoA, stearoyl-CoA, l [...]
fadD10 protein networkhttps://string-db.org/network/83332.Rv0099Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv0099, (MTCY251.18), len: 540 aa. Possible fadD10,fatty-acid-CoA synthetase, similar to many. Contain [...]
Rv0100 protein networkhttps://string-db.org/network/83332.Rv0100Rv0100, (MTCY251.19), len: 78 aa. Conserved hypothetical protein, equivalent only to CAC30950.1|AL583924 conserved hypothetical protein from Mycobacterium leprae (78 aa). A core mycobacterial gen [...]
nrp protein networkhttps://string-db.org/network/83332.Rv0101Rv0101, (MTCY251.20), len: 2512 aa. Probable nrp,peptide synthetase, similar to others e.g. AAD44234.1|AF143772_40|PstB peptide synthetase from Mycobacterium avium (2552 aa); 7476034|S77657 cycli [...]
Rv0102 protein networkhttps://string-db.org/network/83332.Rv0102Rv0102, (MTCY251.21), len: 661 aa. Probable conserved integral membrane protein, highly similar to P53525|Y102_MYCLE|ML1998|NP_302349.1|NC_002677 possible membrane protein from Mycobacterium lepr [...]
ctpB protein networkhttps://string-db.org/network/83332.Rv0103cRv0103c, (MTCY251.22c), len: 752 aa. Probable ctpB,cation-transporting P-type ATPase B (transmembrane protein), equivalent to CTPB_MYCLE|P46840 cation-transporting P-type ATPase B from Mycobacter [...]
Rv0104 protein networkhttps://string-db.org/network/83332.Rv0104Rv0104, (MTCY251.23), len: 504 aa. Conserved hypothetical protein, showing weak similarity with other cAMP-dependent protein kinases e.g. AAC37564.1|M65066 cAMP-dependent protein kinase RI-beta r [...]
rpmB1 protein networkhttps://string-db.org/network/83332.Rv0105cRv0105c, (MTCY251.24c), len: 94 aa. rpmB1, 50S ribosomal protein L28-1, highly similar to others e.g. Q9X8K8|R28B_STRCO 50S ribosomal protein L28-2 from Streptomyces coelicolor (78 aa); RL28_ECOL [...]
Rv0106 protein networkhttps://string-db.org/network/83332.Rv0106Rv0106, (MTCY251.25), len: 398 aa. Conserved hypothetical protein, similar to others e.g. AL049841|SCE9_33 from Streptomyces coelicolor (370 aa),FASTA scores: opt: 282, E(): 2.5e-11, (32.0% ident [...]
ctpI protein networkhttps://string-db.org/network/83332.Rv0107cRv0107c, (MTCY251.26c, MTV031.01c), len: 1632 aa. Probable ctpI, cation-transporting ATPase I P-type, highly similar to NP_302704.1|NC_002677 probable cation transport ATPase from Mycobacterium l [...]
Rv0108c protein networkhttps://string-db.org/network/83332.Rv0108cHypothetical protein; Rv0108c, (MTV031.02c), len: 69 aa. Hypothetical unknown protein.
PE_PGRS1 protein networkhttps://string-db.org/network/83332.Rv0109PE-PGRS family protein PE_PGRS1; Rv0109, (MTV031.03c), len: 496 aa. PE_PGRS1, Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 2002), highly s [...]
Rv0110 protein networkhttps://string-db.org/network/83332.Rv0110Rv0110, (MTV031.04), len: 249 aa. Probable conserved integral membrane protein, similar to many e.g. AL079308|SCH69_25 from Streptomyces coelicolor (297 aa),FASTA scores: opt: 552, E(): 6.1e-29, [...]
Rv0111 protein networkhttps://string-db.org/network/83332.Rv0111Rv0111, (MTV031.05), len: 685 aa. Possible transmembrane acyltransferase, equivalent to AA22904.1|AL035300 putative acyltransferase from Mycobacterium leprae (696 aa). Also similar to others e.g. [...]
gca protein networkhttps://string-db.org/network/83332.Rv0112Rv0112, (MTV031.06), len: 318 aa. Possible gca,GDP-mannose 4,6-dehydratase, similar to others e g. U18320|PAU18320_1 GDP-D-mann from Pseudomonas aeruginosa (323 aa), FASTA scores: opt: 415, E(): [...]
gmhA protein networkhttps://string-db.org/network/83332.Rv0113Probable sedoheptulose-7-phosphate isomerase GmhA (phosphoheptose isomerase); Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS [...]
gmhB protein networkhttps://string-db.org/network/83332.Rv0114D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase; Converts the D-glycero-alpha-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1-phosphate by remo [...]
hddA protein networkhttps://string-db.org/network/83332.Rv0115Rv0115, (MTV031.09), len: 386 aa. Possible hddA,D-alpha-D-heptose-7-phosphate kinase (see citation below),similar to several hypothetical proteins and sugar kinases e.g. AAK27850.1|AF324836_3 D-g [...]
ldtA protein networkhttps://string-db.org/network/83332.Rv0116cProbable L,D-transpeptidase LdtA; Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond betwee [...]
oxyS protein networkhttps://string-db.org/network/83332.Rv0117Rv0117, (MTV031.11), len: 314 aa. OxyS, oxidative stress response protein regulatory protein, LysR family (see citation below). Similar to many transcription regulators and OxyR, the oxidative st [...]
oxcA protein networkhttps://string-db.org/network/83332.Rv0118cRv0118c, (MTV031.12c), Len: 582 aa. Probable oxcA,oxalyl-CoA decarboxylase, highly similar to many e.g. P78093|OXC_ECOLI|7449483|B65011|YFDU|B2373|Z3637|ECS325 probable oxalyl-CoA decarboxylase f [...]
fadD7 protein networkhttps://string-db.org/network/83332.Rv0119Rv0119, (MTV031.13-MTCI418B.01), len: 525 aa. Probable fadD7, fatty-acid-CoA synthetase, similar to 4-coumarate:CoA ligase of many organisms e.g. U39405|PTU39405_1 4-coumarate:CoA ligase from Pin [...]
fusA2 protein networkhttps://string-db.org/network/83332.Rv0120cRv0120c, (MTCI418B.02c), len: 714 aa. Probable fusA2 (alternate gene name: fus2), elongation factor G, highly similar to others e.g. EFG_ECOLI|P02996 elongation factor G (ef-g) from Escherichia c [...]
Rv0121c protein networkhttps://string-db.org/network/83332.Rv0121cConserved protein; Rv0121c, (MTCI418B.03c), len: 144 aa. Conserved protein, showing some similarity with others proteins from Mycobacterium tuberculosis e.g. Rv1155, Rv1875, Rv2074,etc.
Rv0122 protein networkhttps://string-db.org/network/83332.Rv0122Hypothetical protein; Rv0122, (MTCI418B.04), len: 122 aa. Hypothetical unknown protein.
Rv0123 protein networkhttps://string-db.org/network/83332.Rv0123Unknown protein; Rv0123, (MTCI418B.05), len: 122 aa. Unknown protein.
PE_PGRS2 protein networkhttps://string-db.org/network/83332.Rv0124PE-PGRS family protein PE_PGRS2; Rv0124, (MTCI418B.06), len: 487 aa. PE_PGRS2, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 200 [...]
pepA protein networkhttps://string-db.org/network/83332.Rv0125Rv0125, (MTCI418B.07, MTB32A), len: 355 aa. Probable pepA (alternate gene name: mtb32a), serine protease (see Skeiky et al., 1999), highly similar to other proteases e.g. HHOB_ECOLI|P31137 protea [...]
treS protein networkhttps://string-db.org/network/83332.Rv0126Trehalose synthase TreS; Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D- [...]
mak protein networkhttps://string-db.org/network/83332.Rv0127Maltokinase Mak; Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate (By similarity). Is involved in a branched alpha- glucan biosynthetic pathway from trehalose, togeth [...]
Rv0128 protein networkhttps://string-db.org/network/83332.Rv0128Rv0128, (MTCI5.02), len: 259 aa. Probable conserved transmembrane protein, with some similarity to Rv3064c and other bacterial proteins e.g. AAK85977.1|AE007957|AGR_C_254p from Agrobacterium tume [...]
fbpC protein networkhttps://string-db.org/network/83332.Rv0129cDiacylglycerol acyltransferase/mycolyltransferase Ag85C; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycopro [...]
htdZ protein networkhttps://string-db.org/network/83332.Rv0130Probable 3-hydroxyl-thioester dehydratase; Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. In vitro, can hydrate (2E)-butenoyl-CoA, (2E)-hexenoyl-CoA and (2E)-decenoyl-CoA [...]
fadE1 protein networkhttps://string-db.org/network/83332.Rv0131cRv0131c, (MTCI5.05c), len: 447 aa. Probable fadE1,acyl-CoA dehydrogenase, similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase short-chain specific precursor (412 aa), FASTA scores: opt: [...]
fgd2 protein networkhttps://string-db.org/network/83332.Rv0132cPutative F420-dependent glucose-6-phosphate dehydrogenase Fgd2; Catalyzes the coenzyme F420-dependent oxidation of hydroxymycolic acids (H-MAs) to ketomycolic acids (K-MAs), a lipid class making [...]
Rv0133 protein networkhttps://string-db.org/network/83332.Rv0133GCN5-related N-acetyltransferase; Rv0133, (MTCI5.07), len: 201 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005. [...]
ephF protein networkhttps://string-db.org/network/83332.Rv0134Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase); Rv0134, (MTCI5.08), len: 300 aa. Possible ephE,epoxide hydrolase (see citation below), similar to others e.g. Q39856 e [...]
Rv0135c protein networkhttps://string-db.org/network/83332.Rv0135cRv0135c, (MTCI5.09c), len: 201 aa. Possible transcriptional regulator, weakly similar to others e.g. P32398|YHGD_BACSU hypothetical transcriptional regulator from Bacillus subtilis (191 aa), FAST [...]
cyp138 protein networkhttps://string-db.org/network/83332.Rv0136Rv0136, (MT0144, MTCI5.10), len: 441 aa. Probable cyp138, cytochrome P450 138, similar to others e.g. SLR0574|Q59990 from synechocystis SP. (444 aa), FASTA scores: opt: 315, E(): 1e-13, (25.7% id [...]
msrA protein networkhttps://string-db.org/network/83332.Rv0137cPeptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of met [...]
Rv0138 protein networkhttps://string-db.org/network/83332.Rv0138Rv0138, (MTCI5.12), len: 167 aa. Conserved hypothetical protein, showing weak similarity to Q10827|YT10_MYCTU hypothetical 17.0 KDA protein from Mycobacterium tuberculosis (147 aa), FASTA scores: [...]
Rv0139 protein networkhttps://string-db.org/network/83332.Rv0139Rv0139, (MTCI5.13), len: 340 aa. Possible oxidoreductase, similar to others e.g. O34285|HPNA HPNA protein from Zymomonas mobilis (337 aa), FASTA scores: opt: 507, E (): 5.8e-27, (31.1% identity i [...]
Rv0140 protein networkhttps://string-db.org/network/83332.Rv0140Conserved protein; Rv0140, (MTCI5.14), len: 126 aa. Conserved protein,similar to others e.g. P74567|D90916_48 hypothetical 20.8 KDP protein from Synechocystis sp. (180 aa), FASTA scores: opt: 229 [...]
Rv0141c protein networkhttps://string-db.org/network/83332.Rv0141cUnknown protein; Rv0141c, (MTCI5.15c), len: 136 aa. Unknown protein.
Rv0142 protein networkhttps://string-db.org/network/83332.Rv0142Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa).
Rv0143c protein networkhttps://string-db.org/network/83332.Rv0143cRv0143c, (MTCI5.17c), len: 492 aa. Probable conserved transmembrane protein, CIC family possibly involved in transport of chloride, similar to others and hypothetical proteins e.g. O28857 putativ [...]
Rv0144 protein networkhttps://string-db.org/network/83332.Rv0144Probable transcriptional regulatory protein (possibly TetR-family); Rv0144, (MTCI5.18), len: 280 aa. Probable transcriptional regulator, possibly TetR family. Has region similar to others e.g. Q5 [...]
Rv0145 protein networkhttps://string-db.org/network/83332.Rv0145Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv0146 protein networkhttps://string-db.org/network/83332.Rv0146Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv0147 protein networkhttps://string-db.org/network/83332.Rv0147Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde dehydrogenase (NAD+) dependent, similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: [...]
Rv0148 protein networkhttps://string-db.org/network/83332.Rv0148Rv0148, (MTCI5.22), len: 286 aa. Probable short-chain dehydrogenase, similar to others, in particular Estradiol 17 beta-dehydrogenases, e.g. DHB4_MOUSE|P51660 estradiol 17 beta-dehydrogenase 4 (7 [...]
Rv0149 protein networkhttps://string-db.org/network/83332.Rv0149Rv0149, (MTCI5.23), len: 322 aa. Possible quinone oxidoreductase, similar to others oxidoreductases e.g. Q08257 quinone oxidoreductase (329 aa), FASTA scores: opt: 397, E(): 3.2e-18, (28.4% ident [...]
PE1 protein networkhttps://string-db.org/network/83332.Rv0151cRv0151c, (MTCI5.25c), len: 588 aa. PE1, Member of the Mycobacterium tuberculosis PE family (see citation below), with N-terminal region similar to others e.g. MTV032_2 PE_PGRS family from Mycobac [...]
PE2 protein networkhttps://string-db.org/network/83332.Rv0152cRv0152c, (MTCI5.26c), len: 525 aa. PE2, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to ORF downstream Z92770|MTCI5_25 (588 aa),FASTA scores: opt: 1492, E(): 0 [...]
ptbB protein networkhttps://string-db.org/network/83332.Rv0153cRv0153c, (MTCI5.27c), len: 276 aa. PtbB (alternate gene name: MPtpB), protein-tyrosine-phosphatase (see citation below), showing some similarity to several protein-tyrosine phosphatases, polyketi [...]
fadE2 protein networkhttps://string-db.org/network/83332.Rv0154cRv0154c, (MTCI5.28c), len: 403 aa. Probable fadE2,acyl-CoA dehydrogenase, similar to many e.g. C-terminal region of O01590 acyl-CoA dehydrogenase (974 aa), FASTA scores: opt: 1150, E(): 0, (50.0% [...]
pntAa protein networkhttps://string-db.org/network/83332.Rv0155Rv0155, (MTCI5.29), len: 366 aa. Probable pntAa,first part of NAD(P) transhydrogenase subunit alpha,similar to N-terminus of others e.g. PNTA_ECOLI|P07001|P76888|B1603 NAD (P) transhydrogenase su [...]
pntAb protein networkhttps://string-db.org/network/83332.Rv0156Rv0156, (MTCI5.30), len: 110 aa. Probable pntAb,second part of NAD(P) transhydrogenase subunit alpha,integral membrane protein, similar to C-terminus of others e.g. Q59764 nicotinamide nucleotide [...]
pntB protein networkhttps://string-db.org/network/83332.Rv0157NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the [...]
Rv0157A protein networkhttps://string-db.org/network/83332.Rv0157ARv0157A, len: 42 aa. Conserved protein, showing similarity to C-terminal part (aa 186-220) of O53976|Rv1975|MTV051.13 conserved hypothetical protein from Mycobacterium tuberculosis (221 aa), FAST [...]
Rv0158 protein networkhttps://string-db.org/network/83332.Rv0158Probable transcriptional regulatory protein (possibly TetR-family); Rv0158, (MTV032.01), len: 214 aa. Probable transcriptional regulator, possibly TetR family, showing weak similarity to various [...]
PE3 protein networkhttps://string-db.org/network/83332.Rv0159cPE family protein PE3; Plays significant roles in mycobacterial persistence during infection and modulates host immune response.
PE4 protein networkhttps://string-db.org/network/83332.Rv0160cRv0160c, (MTV032.03c), len: 502 aa. PE4, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to many other PE proteins e.g. Z92770|MTCI5_26c from Mycobacterium tuberc [...]
Rv0161 protein networkhttps://string-db.org/network/83332.Rv0161Possible oxidoreductase; Rv0161, (MTCI28.01, MTV032.04), len: 449 aa. Possible oxidoreductase, similar to hypothetical proteins and various oxidoreductases e.g. AIP2_YEAST|P46681 actin interactin [...]
adhE1 protein networkhttps://string-db.org/network/83332.Rv0162cRv0162c, (MTCI28.02c), len: 383 aa. Probable adhE1,zinc-type alcohol dehydrogenase, similar to others e.g. ADH_MACMU|P28469 alcohol dehydrogenase alpha chain (374 aa), FASTA scores: opt: 619, E() [...]
Rv0163 protein networkhttps://string-db.org/network/83332.Rv0163Conserved protein; Rv0163, (MTCI28.03), len: 151 aa. Conserved protein,similar to others e.g. Q44017 hypothetical 16.6 KDA protein in GBD 5'region (ORF6)from Alcaligenes eutrophus (145 aa),FASTA [...]
TB18.5 protein networkhttps://string-db.org/network/83332.Rv0164Conserved protein TB18.5; Rv0164, (MTCI28.04), len: 161 aa. TB18.5, conserved protein, equivalent to CAB08818.1|Z95398 hypothetical protein from Mycobacterium leprae (156 aa) FASTA scores: opt: 7 [...]
mce1R protein networkhttps://string-db.org/network/83332.Rv0165cProbable transcriptional regulatory protein Mce1R (probably GntR-family); Rv0165c, (MTCI28.05c), len: 223 aa. Probable mce1R,transcriptional regulator, GntR family (See Casali et al.,2006), showi [...]
fadD5 protein networkhttps://string-db.org/network/83332.Rv0166Rv0166, (MTCI28.06), len: 554 aa. Probable fadD5,fatty-acid-CoA synthetase, similar to many eg LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 612, E(): 0, (29.4% [...]
yrbE1A protein networkhttps://string-db.org/network/83332.Rv0167Rv0167, (MTCI28.07), len: 265 aa. YrbE1A, unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis prot [...]
yrbE1B protein networkhttps://string-db.org/network/83332.Rv0168Rv0168, (MTCI28.08), len: 289 aa. YrbE1B, unknown integral membrane protein, part of mce1 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis prot [...]
mce1A protein networkhttps://string-db.org/network/83332.Rv0169Mce-family protein Mce1A; Rv0169, (MTCI28.09), len: 454 aa. Mce1A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
mce1B protein networkhttps://string-db.org/network/83332.Rv0170Mce-family protein Mce1B; Rv0170, (MTCI28.10), len: 346 aa. Mce1B (alternate gene name: mceD); belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below),highly si [...]
mce1C protein networkhttps://string-db.org/network/83332.Rv0171Mce-family protein Mce1C; Rv0171, (MTCI28.11), len: 515 aa. Mce1C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
mce1D protein networkhttps://string-db.org/network/83332.Rv0172Mce-family protein Mce1D; Rv0172, (MTCI28.12), len: 530 aa. Mce1D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
lprK protein networkhttps://string-db.org/network/83332.Rv0173Rv0173, (MTCI28.13), len: 390 aa. Possible lprK (alternate gene name: mce1E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly [...]
mce1F protein networkhttps://string-db.org/network/83332.Rv0174Mce-family protein Mce1F; Rv0174, (MTCI28.14), len: 515 aa. Mce1F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosi [...]
Rv0175 protein networkhttps://string-db.org/network/83332.Rv0175Rv0175, (MTCI28.15), len: 213 aa. Probable conserved Mce-associated membrane protein, equivalent, but longer in N-terminus, to CAC32127.1|AL583926 possible membrane protein from Mycobacterium lep [...]
Rv0176 protein networkhttps://string-db.org/network/83332.Rv0176Rv0176, (MTCI28.16), len: 322 aa. Probable conserved Mce-associated transmembrane protein. Contains short region of similarity to PRA_MYCLE|P41484 proline-rich antigen (36 kDa antigen) from Mycob [...]
Rv0177 protein networkhttps://string-db.org/network/83332.Rv0177Rv0177, (MTCI28.17), len: 184 aa. Probable conserved Mce-associated protein, equivalent to CAC32129.1|AL583926 conserved membrane protein from Mycobacterium leprae (184 aa). Also similar to mce-a [...]
Rv0178 protein networkhttps://string-db.org/network/83332.Rv0178Rv0178, (MTCI28.18), len: 244 aa. Probable conserved Mce-associated membrane protein, highly similar in C-terminus to CAC32130.1|AL583926 putative secreted protein from Mycobacterium leprae (184 [...]
lprO protein networkhttps://string-db.org/network/83332.Rv0179cRv0179c, (MTCI28.19c), len: 369 aa. Possible lprO,lipoprotein (visibly not conserved). Contains possible N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment s [...]
Rv0180c protein networkhttps://string-db.org/network/83332.Rv0180cRv0180c, (MTCI28.20c), len: 452 aa. Probable conserved transmembrane protein, equivalent to CAC32132.1|AL583926 probable conserved membrane protein from Mycobacterium leprae (465 aa). Shows some [...]
Rv0181c protein networkhttps://string-db.org/network/83332.Rv0181cConserved hypothetical protein; Putative quercetin 2,3-dioxygenase; Belongs to the pirin family.
sigG protein networkhttps://string-db.org/network/83332.Rv0182cProbable alternative RNA polymerase sigma factor SigG (RNA polymerase ECF type sigma factor); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initia [...]
Rv0183 protein networkhttps://string-db.org/network/83332.Rv0183Possible lysophospholipase; Involved in the hydrolysis of exogenous host lipids during chronic infection. Catalyzes the hydrolysis of both monoacylglycerols (MAG) and diacylglycerols (DAG). It hy [...]
Rv0184 protein networkhttps://string-db.org/network/83332.Rv0184Rv0184, (MTCI28.24), len: 249 aa. Conserved hypothetical protein, equivalent to CAC32136.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (249 aa); and C-terminus highly simila [...]
Rv0185 protein networkhttps://string-db.org/network/83332.Rv0185Rv0185, (MTCI28.25a), len: 169 aa. Conserved hypothetical protein, equivalent to CAB08794.1|Z95398|MLCL622_2 from Mycobacterium leprae (168 aa), FASTA scores: opt: 861, E(): 0, (76.4% identity in [...]
bglS protein networkhttps://string-db.org/network/83332.Rv0186Probable beta-glucosidase BglS (gentiobiase) (cellobiase) (beta-D-glucoside glucohydrolase); Rv0186, (MTCI28.25b), len: 691 aa. Probable bglS,beta-glucosidase, highly similar to many e.g. BGLS_AG [...]
mymT protein networkhttps://string-db.org/network/83332.Rv0186AMetallothionein, MymT; Metallothioneins are small proteins that have a high content of cysteine residues wich allow them to bind heavy metal ions through clusters of thiolate bonds. MymT binds up [...]
Rv0187 protein networkhttps://string-db.org/network/83332.Rv0187Probable O-methyltransferase; Catechol O-methyltransferase that can use various catechol- like compounds such as gallic acid (GA), 3,4-dihydroxy-5-methoxy- benzoic acid (5OMeBA), protocatechuic a [...]
Rv0188 protein networkhttps://string-db.org/network/83332.Rv0188Rv0188, (MTCI28.27), len: 143 aa. Probable conserved transmembrane protein, similar to T35347|4835334|CAB42956.1|AL049863|SC5H1_31 probable membrane protein from Streptomyces coelicolor (147 aa), [...]
ilvD protein networkhttps://string-db.org/network/83332.Rv0189cRv0189c, (MTCI28.28c), len: 575 aa. Probable ilvD,dihydroxy-acid dehydratase, similar to many e.g. ILVD_LACLA|Q02139 dihydroxy-acid dehydratase (dad) from Lactococcus lactis (subsp. lactis) (Stre [...]
ricR protein networkhttps://string-db.org/network/83332.Rv0190Conserved protein; Under low copper conditions, represses the expression of lpqS, Rv2963, mymT, socA, socB, mmcO and its own expression. In the presence of copper, RicR dissociates from DNA, lead [...]
Rv0191 protein networkhttps://string-db.org/network/83332.Rv0191Probable conserved integral membrane protein; Active efflux pump that plays an important role in chloramphenicol resistance. Overexpression causes pyrazinamide resistance. Belongs to the major fa [...]
Rv0192 protein networkhttps://string-db.org/network/83332.Rv0192Conserved hypothetical protein; Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between [...]
Rv0192A protein networkhttps://string-db.org/network/83332.Rv0192AConserved secreted protein; Rv0192A, len: 100 aa. Probable N-terminal part of Rv0192, which is member of family P5.17 with Rv0116c,Rv1433, Rv2518c, Rv0483. These are all predicted to be exported/ [...]
Rv0193c protein networkhttps://string-db.org/network/83332.Rv0193cHypothetical protein; Rv0193c, (MTV033.01c-MTCI28.32), len: 615 aa. Hypothetical unknown protein.
Rv0194 protein networkhttps://string-db.org/network/83332.Rv0194Probable transmembrane multidrug efflux pump; Overexpression in M. smegmatis increases resistance to erythromycin, ampicillin, novobiocin and vancomycin. It also reduces accumulation of ethidium [...]
Rv0195 protein networkhttps://string-db.org/network/83332.Rv0195Rv0195, (MTV033.03), len: 211 aa. Possible two-component response regulator, luxR family, similar to many e.g. U00008|ECOHU49_15 regulatory protein narP from Escherichia coli strain K12 (225 aa), [...]
Rv0196 protein networkhttps://string-db.org/network/83332.Rv0196Rv0196, (MTV033.04), len: 194 aa. Possible transcriptional regulatory protein, similar to two Bacillus subtilis regulators: P42105|YXAF_BACSU hypothetical 21.0 kDa protein (191 aa), FASTA scores: [...]
Rv0197 protein networkhttps://string-db.org/network/83332.Rv0197Rv0197, (MTV033.05), len: 762 aa. Possible oxidoreductase, similar to others e.g. 9948789|AAG06102.1|AE004699_7|B83307 probable molybdopterin oxidoreductase from Pseudomonas aeruginosa strain PAO [...]
zmp1 protein networkhttps://string-db.org/network/83332.Rv0198cRv0198c, (MTV033.06c), len: 663 aa. Probable zmp1,zinc metalloprotease, equivalent to Z95398|MLCL622.12c from Mycobacterium leprae (667 aa), FASTA scores: opt: 3710,E(): 0, (80.8 % identity in 66 [...]
Rv0199 protein networkhttps://string-db.org/network/83332.Rv0199Rv0199, (MTV033.07), len: 219 aa. Probable conserved membrane protein, equivalent to Z95398|MLCL622.13 from Mycobacterium leprae (224 aa), FASTA scores: opt: 920, E(): 0, (67.7% identity in 220 a [...]
Rv0200 protein networkhttps://string-db.org/network/83332.Rv0200Rv0200, (MTV033.08), len: 229 aa. Possible conserved transmembrane protein, equivalent to Z95398|MLCL622.14 from Mycobacterium leprae (229 aa), FASTA scores: opt: 1147,E(): 0, (74.7% identity in [...]
Rv0201c protein networkhttps://string-db.org/network/83332.Rv0201cConserved protein; Rv0201c, (MTV033.09c), len: 167 aa. Conserved protein, equivalent to Z95398|MLCL622.15c from Mycobacterium leprae (170 aa), FASTA scores: opt: 646, E(): 0, (63.9% identity in 1 [...]
mmpL11 protein networkhttps://string-db.org/network/83332.Rv0202cProbable conserved transmembrane transport protein MmpL11; Part of a heme-iron acquisition system. Receives heme from the heme-binding protein Rv0203 and transports it into the mycobacterial cell [...]
Rv0203 protein networkhttps://string-db.org/network/83332.Rv0203Possible exported protein; Part of a heme-iron acquisition system. Acts by binding heme and delivering it to the membrane proteins MmpL3 and MmpL11. Can use free heme or heme from host hemoglobin [...]
Rv0204c protein networkhttps://string-db.org/network/83332.Rv0204cRv0204c, (MTV033.12c), len: 412 aa. Probable conserved transmembrane protein (see citation below),equivalent, but has C-terminal extension, to Z95398|MLCL622.17c from Mycobacterium leprae (367 aa [...]
Rv0205 protein networkhttps://string-db.org/network/83332.Rv0205Rv0205, (MTV033.13), len: 367 aa. Possible conserved transmembrane protein, similar to hypothetical proteins from many bacteria e.g. AL0209|SC4H8_6 from Streptomyces coelicolor (402 aa), FASTA sc [...]
mmpL3 protein networkhttps://string-db.org/network/83332.Rv0206cPossible conserved transmembrane transport protein MmpL3; Transports trehalose monomycolate (TMM) across the inner membrane. Could also be part of a heme-iron acquisition system. Belongs to the r [...]
Rv0207c protein networkhttps://string-db.org/network/83332.Rv0207cRv0207c, (MTCY08D5.02c), len: 242 aa. Conserved hypothetical protein, equivalent to Z95398|MLCL622_19 from Mycobacterium leprae (261 aa), FASTA scores: E(): 0, (60.8 identity in 199 aa overlap). [...]
trmB protein networkhttps://string-db.org/network/83332.Rv0208cHypothetical methlytransferase (methylase); Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Tr [...]
Rv0209 protein networkhttps://string-db.org/network/83332.Rv0209Hypothetical protein; Rv0209, (MTCY08D5.04), len: 361 aa. Hypothetical unknown protein.
Rv0210 protein networkhttps://string-db.org/network/83332.Rv0210Hypothetical protein; Rv0210, (MTCY08D5.05), len: 492 aa. Hypothetical unknown protein. Possibly membrane protein; has hydrophobic stretches around aa 333 - 381.
pckA protein networkhttps://string-db.org/network/83332.Rv0211Phosphoenolpyruvate carboxykinase [GTP]; Involved in the gluconeogenesis, in growth on fatty acids and is important for initiation of infection in the macrophages. Catalyzes the GTP-dependent con [...]
nadR protein networkhttps://string-db.org/network/83332.Rv0212cPossible transcriptional regulatory protein NadR (probably AsnC-family); Rv0212c, (MTCY08D5.07c), len: 323 aa. Possible nadR (alternate gene name: nadI), transcriptional regulator,similar to othe [...]
Rv0213c protein networkhttps://string-db.org/network/83332.Rv0213cRv0213c, (MTCY08D5.08c), len: 437 aa. Possible methyltransferase, weakly similar to others methyltransferases e.g. AF127374_30|LINA from Streptomyces lavendulae (611 aa), FASTA scores: opt: 400, [...]
fadD4 protein networkhttps://string-db.org/network/83332.Rv0214Rv0214, (MTCY08D5.09), len: 537 aa. Probable fadD4,fatty-acid-CoA synthetase, similar to many e.g. 4CL_PINTA|P41636 4-coumarate--CoA ligase (537 aa), FASTA scores: opt: 622, E(): 1e-31, (30.0% id [...]
fadE3 protein networkhttps://string-db.org/network/83332.Rv0215cRv0215c, (MTCY08D5.10c), len: 357 aa. Probable fadE3, acyl- dehydrogenase, similar to many e.g. ACDB_BACSU|P45857 acyl-CoA dehydrogenase from B. subtilis (379 aa), FASTA scores: opt: 812, E(): 0, [...]
Rv0216 protein networkhttps://string-db.org/network/83332.Rv0216Double hotdog hydratase; Rv0216, (MTCY08D5.11), len: 337 aa. Double hotdog R-specific hydratase of unknown function, shows no activity for crotonyl-CoA, equivalent to Z95398|MLCL622_22 from Mycob [...]
lipW protein networkhttps://string-db.org/network/83332.Rv0217cPossible esterase LipW; Rv0217c, (MTCY08D5.12c), len: 302 aa. Possible esterase, showing similarity with others e.g. EST_ACICA|P18773 esterase (303 aa), FASTA scores: opt: 320,E(): 3.2e-13, (29.2 [...]
Rv0218 protein networkhttps://string-db.org/network/83332.Rv0218Rv0218, (MTCY08D5.13), len: 442 aa. Probable conserved transmembrane protein, some similarity with sulfite oxidases e.g. SUOX_HUMAN|P51687 sulfite oxidase precursor (488 aa), FASTA scores: opt: 1 [...]
Rv0219 protein networkhttps://string-db.org/network/83332.Rv0219Rv0219, (MTCY08D5.14), len: 182 aa. Probable conserved transmembrane protein, showing similarity with CAB76992.1|AL159178 putative lipoprotein from Streptomyces coelicolor (163 aa).
lipC protein networkhttps://string-db.org/network/83332.Rv0220Probable esterase LipC; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 10 carbon atoms. Does not have lipase activity. Is highly immunogenic and elicits stro [...]
Rv0221 protein networkhttps://string-db.org/network/83332.Rv0221Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
echA1 protein networkhttps://string-db.org/network/83332.Rv0222Probable enoyl-CoA hydratase EchA1 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0222, (MTCY08D5.17), len: 262 aa. Probable echA1,enoyl-CoA hydratase, similar to others e.g. AAC [...]
Rv0223c protein networkhttps://string-db.org/network/83332.Rv0223cRv0223c, (MTCY08D5.18), len: 487 aa. Probable aldehyde dehydrogenase, similar to others e.g. A75608|6460525|AAF12231.1|AE001862_57 aldehyde dehydrogenase from Deinococcus radiodurans strain R1 (4 [...]
Rv0224c protein networkhttps://string-db.org/network/83332.Rv0224cRv0224c, (MTCY08D5.19c), len: 254 aa. Possible methyltransferase, showing weak similarity with other methyltransferases e.g. P74388 sterol-C-methyltransferase (318 aa), FASTA scores: opt: 190, E( [...]
Rv0225 protein networkhttps://string-db.org/network/83332.Rv0225Possible conserved protein; Rv0225, (MTCY08D5.20), len: 384 aa. Possible conserved protein involved in LPS biosynthesis, similar to O26275 LPS biosynthesis RFBU related protein (382 aa),FASTA sco [...]
Rv0226c protein networkhttps://string-db.org/network/83332.Rv0226cRv0226c, (MTCY08D5.21c), len: 576 aa. Probable conserved transmembrane protein, equivalent, except in N-terminal part, to AC32114.1|AL583926 conserved membrane protein from Mycobacterium leprae ( [...]
Rv0227c protein networkhttps://string-db.org/network/83332.Rv0227cRv0227c, (MTCY08D5.22c), len: 421 aa. Possible conserved membrane protein, equivalent to AL022486|MLCB1883_4 from Mycobacterium leprae (448 aa),FASTA scores: opt: 2148, E(): 0, (76.6% identity in [...]
Rv0228 protein networkhttps://string-db.org/network/83332.Rv0228Rv0228, (MTCY08D5.23), len: 407 aa. Probable integral membrane acyltransferase, equivalent to 3063875|CAA18555.1|AL022486|T44870 acyltransferase from Mycobacterium leprae (384 aa), FASTA scores: [...]
vapC51 protein networkhttps://string-db.org/network/83332.Rv0229cPossible conserved membrane protein with PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB51; Belongs to the PINc/VapC protein family.
php protein networkhttps://string-db.org/network/83332.Rv0230cPhosphotriesterase homology protein; Rv0230c, (MTCY08D5.26c), len: 326 aa. Probable php,phosphotriesterase, similar to others e.g. AAK42653.1|AE006849 putative aryldialkylphosphatase (phosphotrie [...]
fadE4 protein networkhttps://string-db.org/network/83332.Rv0231Rv0231, (MTCY08D5.27), len: 568 aa. Probable fadE4,acyl-CoA dehydrogenase, similar to many e.g. O29752 acyl-CoA dehydrogenase (ACD-3) from Archaeoglobus fulgidus (576 aa), FASTA scores: opt: 1788 [...]
Rv0232 protein networkhttps://string-db.org/network/83332.Rv0232Rv0232, (MTCY08D5.28), len: 229 aa. Probable transcriptional regulatory protein, TetR/AcrR family,similar to others e.g. YIXD_BACSU|P32398 hypothetical transcriptional regulator (191 aa), FASTA s [...]
nrdB protein networkhttps://string-db.org/network/83332.Rv0233Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain); Probable oxidase that might be involved in lipid metabolism.
gabD1 protein networkhttps://string-db.org/network/83332.Rv0234cSuccinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1; Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succ [...]
Rv0235c protein networkhttps://string-db.org/network/83332.Rv0235cRv0235c, (MTCY08D5.31c), len: 482 aa. Probable conserved transmembrane protein, highly similar to AL133278|CAB61913.1|SCM11_2 putative integral membrane protein from Streptomyces coelicolor (470 [...]
Rv0236A protein networkhttps://string-db.org/network/83332.Rv0236ARv0236A, len: 57 aa. Small secreted protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
aftD protein networkhttps://string-db.org/network/83332.Rv0236cPossible arabinofuranosyltransferase AftD; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of th [...]
lpqI protein networkhttps://string-db.org/network/83332.Rv0237Probable conserved lipoprotein LpqI; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptidoglycan fragments. Acts as a regulato [...]
Rv0238 protein networkhttps://string-db.org/network/83332.Rv0238Rv0238, (MTV034.04), len: 204 aa. Possible transcriptional regulatory protein, TetR family, equivalent to AL022486|MLCB1883_9|T44874 probable transcription regulator from Mycobacterium leprae (20 [...]
vapB24 protein networkhttps://string-db.org/network/83332.Rv0239Possible antitoxin VapB24; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC24.
vapC24 protein networkhttps://string-db.org/network/83332.Rv0240Possible toxin VapC24. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB24 (By similarity). Belongs to the PINc/VapC protein f [...]
htdX protein networkhttps://string-db.org/network/83332.Rv0241cProbable 3-hydroxyacyl-thioester dehydratase HtdX; Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. Displays a broad chain length specificity, with a predilection for the C [...]
fabG4 protein networkhttps://string-db.org/network/83332.Rv0242cRv0242c, (MTV034.08c), len: 454 aa. Probable fabG4,3-oxoacyl-[acyl-carrier protein] reductase, equivalent to 3063883|CAA18568.1|AL022486|MLCB1883_13|T44878 3-oxoacyl-[acyl-carrier protein] reduct [...]
fadA2 protein networkhttps://string-db.org/network/83332.Rv0243Rv0243, (MTV034.09), len: 440 aa. Probable fadA2,acetyl-CoA acyltransferase (3-acyl-CoA thiolase),equivalent, but shorter 17 aa, to AL022486|MLCB1883_14T44879 acetyltransferase from Mycobacterium [...]
fadE5 protein networkhttps://string-db.org/network/83332.Rv0244cRv0244c, (MTV034.10c), len: 611 aa. Probable fadE5,acyl-CoA dehydrogenase, equivalent to AL022486|MLCB1883_15 from Mycobacterium leprae (611 aa), FASTA scores: opt: 3598, E(): 0, (89.4% identity [...]
Rv0245 protein networkhttps://string-db.org/network/83332.Rv0245Rv0245, (MTV034.11), len: 162 aa. Possible oxidoreductase, equivalent to AL022486|MLCB1883_17|T44882 probable oxidoreductase from Mycobacterium leprae (162 aa),FASTA scores: opt: 860, E(): 0, (83 [...]
Rv0246 protein networkhttps://string-db.org/network/83332.Rv0246Rv0246, (MTV034.12), len: 436 aa (start uncertain). Probable conserved integral membrane protein, similar to Rv2209|1237062|CAA94252.1|Z70283|Q10398|YM09_MYCTU from Mycobacterium tuberculosis (51 [...]
Rv0247c protein networkhttps://string-db.org/network/83332.Rv0247cProbable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase); Rv0247c, (MTV034.13c), len: 248 aa. Probable succinate dehydrogenase, iron-sulfur subunit, highly similar to CAC44 [...]
Rv0248c protein networkhttps://string-db.org/network/83332.Rv0248cProbable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase); Rv0248c, (MTV034.14c), len: 646 aa. Probable succinate dehydrogenase, flavoprotein subunit, highly similar to flav [...]
Rv0249c protein networkhttps://string-db.org/network/83332.Rv0249cRv0249c, (MTV034.15c), len: 273 aa. Probable succinate dehydrogenase, membrane-anchor subunit for succinate dehydrogenase encoded by Rv0247c and Rv0248c. Highly similar to AC44315.1|AL596043 puta [...]
Rv0250c protein networkhttps://string-db.org/network/83332.Rv0250cConserved protein; Rv0250c, (MTV034.16c), len: 97 aa. Conserved protein, equivalent to MLCB1883.27c|T44883|3063888|CAA18576.1|AL022486 hypothetical protein from Mycobacterium leprae (98 aa),FASTA [...]
hsp protein networkhttps://string-db.org/network/83332.Rv0251cRv0251c, (MTV034.17c), len: 159 aa. Hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF0 [...]
nirB protein networkhttps://string-db.org/network/83332.Rv0252Rv0252, (MTV034.18), len: 853 aa. Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit, flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly si [...]
nirD protein networkhttps://string-db.org/network/83332.Rv0253Rv0253, (MTV034.19), len: 118 aa. Probable nirD,nitrite reductase [NAD(P)H] small subunit, similar to others e.g. P23675|NIRD_ECOLI|B3366|Z4727|ECS4217 from Escherichia coli strains K12 and O157: [...]
cobU protein networkhttps://string-db.org/network/83332.Rv0254cRv0254c, (MTV034.20), len: 174 aa. Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase and cobinamide phosphate guanylyltransferase. Highly similar to many e.g. Q05599|COBU [...]
cobQ1 protein networkhttps://string-db.org/network/83332.Rv0255cProbable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydroge [...]
PPE2 protein networkhttps://string-db.org/network/83332.Rv0256cRv0256c, (MTV034.22c), len: 556 aa. PPE2, Member of the M. tuberculosis PPE family, similar to many e.g. Rv0280, Rv0286, etc. Equivalent to Z98756|MLCB2492.30 from Mycobacterium leprae (572 aa), [...]
Rv0257 protein networkhttps://string-db.org/network/83332.Rv0257Rv0257, len: 124 aa. Hypothetical protein,orthologue of ML1828A conserved hypothetical protein from Mycobacterium leprae. Replaced Rv0257c (older annotation). A core mycobacterial gene; conserved [...]
Rv0258c protein networkhttps://string-db.org/network/83332.Rv0258cConserved hypothetical protein; Rv0258c, (MTCY06A4.02c), len: 151 aa (alternative start possible). Conserved hypothetical protein, showing some similarity to Rv1685c|MTCI125_6 from Mycobacterium [...]
Rv0259c protein networkhttps://string-db.org/network/83332.Rv0259cRv0259c, (MTCY06A4.03c), len: 247 aa. Conserved hypothetical protein, showing some similarity to Rv2393|Z81368|MTCY253_28 from Mycobacterium tuberculosis (281 aa), FASTA scores: E(): 9.5e-16, (33 [...]
Rv0260c protein networkhttps://string-db.org/network/83332.Rv0260cPossible transcriptional regulatory protein; Rv0260c, (MTCY0A4.04c), len: 381 aa. Possible two-component response regulator, highly similar to CAB72204.1|AL138851 putative transcriptional regulat [...]
narK3 protein networkhttps://string-db.org/network/83332.Rv0261cRv0261c, (MTCY06A4.05c), len: 469 aa. Probable nirK3, nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),equivalent to AAB41700.1|U72744 n [...]
aac protein networkhttps://string-db.org/network/83332.Rv0262cAminoglycoside 2'-N-acetyltransferase Aac (Aac(2')-IC); May catalyze the coenzyme A-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides and confer resis [...]
Rv0263c protein networkhttps://string-db.org/network/83332.Rv0263cRv0263c, (MTCY06A4.07c), len: 300 aa. Conserved hypothetical protein, equivalent to NP_302634.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (305 aa). Also similar to others [...]
Rv0264c protein networkhttps://string-db.org/network/83332.Rv0264cRv0264c, (MTCY06A4.08c), len: 210 aa. Conserved hypothetical protein, equivalent to CAC32080.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (222 aa). Also similar to others h [...]
Rv0265c protein networkhttps://string-db.org/network/83332.Rv0265cRv0265c, (MTCY06A4.09c), len: 330 aa. Probable iron-transport lipoprotein, most similar to T36412|5763945|CAB53324.1|AL109974 probable iron-siderophore binding lipoprotein from Streptomyces coeli [...]
oplA protein networkhttps://string-db.org/network/83332.Rv0266cRv0266c, (MTCY06A4.10c), len: 1209 aa. Probable oplA, 5-oxoprolinase, highly similar to others or to hypothetical proteins e.g. AAK24340.1|AE005906 hydantoinase/oxoprolinase from Caulobacter cres [...]
narU protein networkhttps://string-db.org/network/83332.Rv0267Rv0267, (MTCY06A4.11), len: 463 aa. Probable narU,nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS),similar to other nitrite extrusion pr [...]
Rv0268c protein networkhttps://string-db.org/network/83332.Rv0268cHypothetical protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system; however the expected toxin coding sequence is not found adjacent to this gene.
Rv0269c protein networkhttps://string-db.org/network/83332.Rv0269cRv0269c, (MTCY06A4.13c), len: 397 aa. Conserved hypothetical protein, highly similar to AL079355|SC4C6_19 hypothetical protein from Streptomyces coelicolor (341 aa),FASTA scores: opt: 1019, E(): [...]
fadD2 protein networkhttps://string-db.org/network/83332.Rv0270Rv0270, (MTCY06A4.14), len: 560 aa. Probable fadD2,fatty-acid-CoA synthetase, similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase from Escherichia coli (561 aa), FASTA scores [...]
fadE6 protein networkhttps://string-db.org/network/83332.Rv0271cRv0271c, (MTCY06A4.15c), len: 731 aa. Probable fadE6, acyl-CoA dehydrogenase, with C-terminal half similar to many e.g. ACDS_HUMAN|P16219 acyl-CoA dehydrogenase (short-chain) from Homo sapiens (4 [...]
Rv0272c protein networkhttps://string-db.org/network/83332.Rv0272cUnknown protein; Rv0272c, (MTCY06A4.16c), len: 377 aa. Unknown protein.
Rv0273c protein networkhttps://string-db.org/network/83332.Rv0273cRv0273c, (MTV035.01c), len: 206 aa (start uncertain). Possible transcriptional regulator, showing some similarity to hypothetical regulators from Mycobacterium tuberculosis e.g. P96222|Rv3855|MTC [...]
Rv0274 protein networkhttps://string-db.org/network/83332.Rv0274Conserved protein; Rv0274, (MTV035.02), len: 193 aa. Conserved protein,highly similar to AAK25058.1|AE005973 conserved hypothetical protein from Caulobacter crescentus (174 aa). Shows also some s [...]
Rv0275c protein networkhttps://string-db.org/network/83332.Rv0275cPossible transcriptional regulatory protein (possibly TetR-family); Rv0275c, (MTV035.03c), len: 241 aa. Possible transcriptional regulator, TetR family, similar to others e.g. Q9RJE7|SCF81.04c pu [...]
Rv0276 protein networkhttps://string-db.org/network/83332.Rv0276Rv0276, (MTV035.04), len: 306 aa. Conserved hypothetical protein, similar to Rv2237|Z70692|MTCY427.18 from Mycobacterium tuberculosis (296 aa), FASTA scores: opt: 874, E(): 0, (49.6% identity in [...]
vapB25 protein networkhttps://string-db.org/network/83332.Rv0277ARv0277A, len: 85 aa. Possible vapB25, antitoxin,part of toxin-antitoxin (TA) operon with Rv0277c, see Arcus et al. 2005. Has in-frame stop codon so may not be expressed. Very similar to others in [...]
vapC25 protein networkhttps://string-db.org/network/83332.Rv0277cPossible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
PE_PGRS3 protein networkhttps://string-db.org/network/83332.Rv0278cPE-PGRS family protein PE_PGRS3; Rv0278c, (MTV035.06c), len: 957 aa. PE_PGRS3, Member of the Mycobacterium tuberculosis PE family (see citation below), PGRS subfamily of gly-rich proteins, simila [...]
PE_PGRS4 protein networkhttps://string-db.org/network/83332.Rv0279cPE-PGRS family protein PE_PGRS4; Rv0279c, (MTV035.07c), len: 837 aa. PE_PGRS4, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 200 [...]
PPE3 protein networkhttps://string-db.org/network/83332.Rv0280Rv0280, (MTV035.08), len: 536 aa. PPE3, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. Z80108|MTCY21B4_4|Rv0453 from Mycobacterium tuberculosis (539 aa), FASTA scores [...]
Rv0281 protein networkhttps://string-db.org/network/83332.Rv0281Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
eccA3 protein networkhttps://string-db.org/network/83332.Rv0282ESX conserved component EccA3. ESX-3 type VII secretion system protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. EccA3 exhibits [...]
eccB3 protein networkhttps://string-db.org/network/83332.Rv0283ESX conserved component EccB3. ESX-3 type VII secretion system protein. Possible membrane protein; An ATPase (By similarity). Part of the ESX-3 specialized secretion system, which is important fo [...]
eccC3 protein networkhttps://string-db.org/network/83332.Rv0284ESX conserved component EccC3. ESX-3 type VII secretion system protein. Possible membrane protein; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or h [...]
PE5 protein networkhttps://string-db.org/network/83332.Rv0285PE family protein PE5; Important for the siderophore-mediated iron-acquisition function of ESX-3. May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates produc [...]
PPE4 protein networkhttps://string-db.org/network/83332.Rv0286PPE family protein PPE4; Important for the siderophore-mediated iron-acquisition function of ESX-3; Belongs to the mycobacterial PPE family.
esxG protein networkhttps://string-db.org/network/83332.Rv0287ESAT-6 like protein EsxG (conserved protein TB9.8); EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. Th [...]
esxH protein networkhttps://string-db.org/network/83332.Rv0288Low molecular weight protein antigen 7 EsxH (10 kDa antigen) (CFP-7) (protein TB10.4); EsxH, in complex with EsxG, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting [...]
espG3 protein networkhttps://string-db.org/network/83332.Rv0289ESX-3 secretion-associated protein EspG3; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers.
eccD3 protein networkhttps://string-db.org/network/83332.Rv0290ESX-3 secretion system protein EccD3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis.
mycP3 protein networkhttps://string-db.org/network/83332.Rv0291Mycosin-3; Rv0291, (MTV035.19), len: 461 aa. Probable mycP3,membrane-anchored serine protease (mycosin) (see Brown et al., 2000), similar to several others in mycobacteria e.g. Z94121|MTY15F10_28 [...]
eccE3 protein networkhttps://string-db.org/network/83332.Rv0292ESX-3 secretion system protein EccE3; Part of the ESX-3 specialized secretion system, which is important for iron and zinc uptake or homeostasis. Belongs to the EccE family.
Rv0293c protein networkhttps://string-db.org/network/83332.Rv0293cConserved protein; Rv0293c, (MTV035.21c), len: 400 aa. Conserved protein, similar in C-terminal part to Rv2627c|B70573|MTCY01A10.05|CAB08637.1|Z95387 conserved hypothetical protein from Mycobacte [...]
tam protein networkhttps://string-db.org/network/83332.Rv0294Probable trans-aconitate methyltransferase Tam; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
stf0 protein networkhttps://string-db.org/network/83332.Rv0295cConserved protein; Catalyzes the sulfuryl group transfer from 3'- phosphoadenosine-5'-phosphosulfate (PAPS) to trehalose, leading to trehalose-2-sulfate (T2S). The sulfation of trehalose is the f [...]
Rv0296c protein networkhttps://string-db.org/network/83332.Rv0296cProbable sulfatase; Rv0296c, (MTCY63.01c, MTV035.24c), len: 465 aa. Probable sulfatase, possibly an aryl-/steryl-sulfatase or a sulfamidase (sulfohydrolase) (sulphamidase). Similar to various hyd [...]
PE_PGRS5 protein networkhttps://string-db.org/network/83332.Rv0297PE-PGRS family protein PE_PGRS5; Involved in endoplasmic reticulum (ER) stress-mediated apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Localizes to the host ER, leading to [...]
Rv0298 protein networkhttps://string-db.org/network/83332.Rv0298Hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0299.
Rv0299 protein networkhttps://string-db.org/network/83332.Rv0299Hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cogn [...]
vapB2 protein networkhttps://string-db.org/network/83332.Rv0300Possible antitoxin VapB2; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC2. The C-terminal helix of the a [...]
vapC2 protein networkhttps://string-db.org/network/83332.Rv0301Possible toxin VapC2; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in M.smegmatis inhibits translation, growth and colony formation. All its toxic e [...]
Rv0302 protein networkhttps://string-db.org/network/83332.Rv0302Rv0302, (MTCY63.07), len: 210 aa. Probable transcription regulatory protein, TetR family (see citation below), with its N-terminus similar to N-terminus of several repressors and regulatory prote [...]
Rv0303 protein networkhttps://string-db.org/network/83332.Rv0303Probable dehydrogenase/reductase; Rv0303, (MTCY63.08), len: 302 aa. Possible dehydrogenase/reductase, similar to various NADPH dehydrogenases and other NADPH oxidoreductases e.g. O48741|PORC_ARAT [...]
PPE5 protein networkhttps://string-db.org/network/83332.Rv0304cRv0304c, (MTCY63.9c), len: 2204 aa. PPE5, Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Z95324|MTY13E10_16 from Mycobacterium tuberculosis (1443 aa), FASTA [...]
PPE6 protein networkhttps://string-db.org/network/83332.Rv0305cRv0305c, (MTCY63.10c), len: 963 aa. PPE6, Member of the Mycobacterium tuberculosis PE family (PPE, MPTR),similar to others e.g. Y04H_MYCTU|Q10778 from Mycobacterium tuberculosis (734 aa), FASTA s [...]
Rv0306 protein networkhttps://string-db.org/network/83332.Rv0306Rv0306, (MTCY63.11), len: 223 aa. Putative oxidoreductase, highly similar to H83485|9947208|AAG04663.1|AE004557_4|AE004557 conserved hypothetical protein from Pseudomonas aeruginosa strain PAO1 ( [...]
Rv0307c protein networkhttps://string-db.org/network/83332.Rv0307cUnknown protein; Rv0307c, (MTCY63.12c), len: 160 aa. Unknown protein.
Rv0308 protein networkhttps://string-db.org/network/83332.Rv0308Rv0308, (MTCY63.13), len: 238 aa. Probable conserved integral membrane protein, with C-terminus highly similar to C-terminus of other integral membrane proteins or phosphatases e.g. AAK25788.1|AF [...]
Rv0309 protein networkhttps://string-db.org/network/83332.Rv0309Rv0309, (MTCY63.14), len: 218 aa. Possible conserved exported protein (has putative N-terminal signal sequence),equivalent to AC32053.1|AL583926 putative secreted protein from Mycobacterium lepra [...]
Rv0310c protein networkhttps://string-db.org/network/83332.Rv0310cConserved protein; Rv0310c, (MTCY63.15c), len: 163 aa. Conserved protein, similar to some bile acid dehydratases e.g. P19412|BAIE_EUBSP|98749|D37844|1381566|AAC45413.1|U57489 bile acid-inducible [...]
Rv0311 protein networkhttps://string-db.org/network/83332.Rv0311Unknown protein; Rv0311, (MTCY63.16), len: 409 aa. Unknown protein. Contains PS00881 Protein splicing signature.
Rv0312 protein networkhttps://string-db.org/network/83332.Rv0312Rv0312, (MTCY63.17), len: 620 aa. Conserved hypothetical protein with highly Pro-, Thr-rich C-terminus. Similar to Pro-,Thr-rich region in Rv2264c|AL021925|MTV022_14 from Mycobacterium tuberculos [...]
Rv0313 protein networkhttps://string-db.org/network/83332.Rv0313Conserved protein; Rv0313, (MTCY63.18), len: 128 aa. Conserved protein,equivalent only to CAC32049.1|AL583926 conserved hypothetical protein from Mycobacterium leprae (130 aa). A core mycobacteri [...]
Rv0314c protein networkhttps://string-db.org/network/83332.Rv0314cRv0314c, (MTCY63.19c), len: 220 aa. Possible conserved membrane protein, with hydrophobic stretch from residues ~75-100. Similar in C-terminal part to Mycobacterium tuberculosis proteins Rv0679c [...]
Rv0315 protein networkhttps://string-db.org/network/83332.Rv0315Rv0315, (MTCY63.20), len: 294 aa. Possible beta-1,3-glucanase precursor (has hydrophobic stretch in its N-terminal part), similar to others e.g. Q51333|AAC44371.1 beta-1,3-glucanase II a from Oer [...]
Rv0316 protein networkhttps://string-db.org/network/83332.Rv0316Rv0316, (MTCY63.21), len: 204 aa. Possible muconolactone isomerase, showing weak similarity with some muconolactone isomerases e.g. O33947|CTC1_ACILW muconolactone delta-isomerase 1 (MIASE 1)(96 [...]
glpQ2 protein networkhttps://string-db.org/network/83332.Rv0317cGlycerophosphoryl diester phosphodiesterase GlpQ2; Rv0317c, (MTCY63.22c), len: 256 aa (start uncertain,chosen by homology). Possible glpQ2, glycerophosphoryl diester phosphodiesterase, similar to [...]
Rv0318c protein networkhttps://string-db.org/network/83332.Rv0318cRv0318c, (MTCY63.23c), len: 264 aa. Probable conserved integral membrane protein, with some similarity to C-terminus of GUFA_MYXXA|Q06916 (254 aa), FASTA scores: opt: 157, E (): 0.0032, (28.3% id [...]
pcp protein networkhttps://string-db.org/network/83332.Rv0319Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.
Rv0320 protein networkhttps://string-db.org/network/83332.Rv0320Rv0320, (MTCY63.25), len: 220 aa. Possible conserved exported protein, similar to some hypothetical proteins and to the middle part of a peptidase: NP_066789.1|10657900|AAG21739.1|AF116907 putati [...]
dcd protein networkhttps://string-db.org/network/83332.Rv0321Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing th [...]
udgA protein networkhttps://string-db.org/network/83332.Rv0322Probable UDP-glucose 6-dehydrogenase UdgA (UDP-GLC dehydrogenase) (UDP-GLCDH) (UDPGDH); Rv0322, (MTCY63.27), len: 443 aa. Probable udg (alternate gene name: rkpK), UDP-glucose 6-dehydrogenase, hi [...]
Rv0323c protein networkhttps://string-db.org/network/83332.Rv0323cRv0323c, (MTCY63.28c), len: 223 aa. Conserved hypothetical protein, similar to others e.g. YPJG_BACSU|P42981 hypothetical 24.8 kDa protein from Bacillus subtilis (224 aa), FASTA scores: opt: 182, [...]
Rv0324 protein networkhttps://string-db.org/network/83332.Rv0324Possible transcriptional regulatory protein (possibly ArsR-family); Rv0324, (MTCY63.29), len: 226 aa. Possible transcriptional regulator, arsR family, with its N-terminus similar to the N-terminu [...]
Rv0325 protein networkhttps://string-db.org/network/83332.Rv0325Hypothetical protein; Rv0325, (MTCY63.30), len: 74 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv0326 protein networkhttps://string-db.org/network/83332.Rv0326Hypothetical protein; Rv0326, (MTCY63.31), len: 151 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
cyp135A1 protein networkhttps://string-db.org/network/83332.Rv0327cRv0327c, (MT0342, MTCY63.32c), len: 449 aa. Possible cyp135A1, cytochrome P450, similar to cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. FQ12609 putative P450 mon [...]
Rv0328 protein networkhttps://string-db.org/network/83332.Rv0328Possible transcriptional regulatory protein (possibly TetR/AcrR-family); Rv0328, (MTCY63.33), len: 200 aa. Possible transcription regulator, TetR/acrR family, similar in part to various hypotheti [...]
Rv0329c protein networkhttps://string-db.org/network/83332.Rv0329cRv0329c, (MTCY63.34c), len: 208 aa. Conserved hypothetical protein, showing some similarity with others hypothetical proteins and methyltransferases e.g. MitM|AF127374_14 methyltransferase from S [...]
Rv0330c protein networkhttps://string-db.org/network/83332.Rv0330cHypothetical protein; Rv0330c, (MTCY63.35c), len: 246 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv0331 protein networkhttps://string-db.org/network/83332.Rv0331Rv0331, (MTCY63.36), len: 388 aa. Possible dehydrogenase/reductase, similar to various dehydrogenases/reductases e.g. NP_103779.1|14022957|BAB49565.1|AP002999 flavoprotein reductase from Mesorhiz [...]
Rv0332 protein networkhttps://string-db.org/network/83332.Rv0332Conserved protein; Rv0332, (MTCY63.37), len: 261 aa. Conserved protein,similar to several conserved hypothetical proteins from Streptomyces coelicolor e.g. SC6A9.18c|AL031035|SC6A9_18|T35449 hypo [...]
Rv0333 protein networkhttps://string-db.org/network/83332.Rv0333Unknown protein; Rv0333, (MTCY63.38), len: 124 aa. Unknown protein.
rmlA protein networkhttps://string-db.org/network/83332.Rv0334Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Involved in the biosynthesis of the dTDP- [...]
PE6 protein networkhttps://string-db.org/network/83332.Rv0335cRv0335c, (MTCY279.02c), len: 171 aa. PE6, Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002); contains short region of similarity to part of the unique N-terminus of t [...]
Rv0336 protein networkhttps://string-db.org/network/83332.Rv0336Conserved 13E12 repeat family protein; Rv0336, (MTCY279.03), len: 503 aa. Part of Mycobacterium tuberculosis 13E12 repeat family; almost identical to Rv0515|MTCY20G10.05 hypothetical protein from [...]
aspC protein networkhttps://string-db.org/network/83332.Rv0337cRv0337c, (MTCY279.04c), len: 429 aa. Probable aspC,aspartate aminotransferase (transaminase A), equivalent to CAC32019.1|AL583925 probable aspartate aminotransferase from Mycobacterium leprae (43 [...]
Rv0338c protein networkhttps://string-db.org/network/83332.Rv0338cRv0338c, (MTCY279.05c), len: 882 aa. Probable iron-sulphur-binding reductase, possibly membrane-bound,equivalent to CAC32018.1|AL583925 probable iron-sulphur-binding reductase from Mycobacterium [...]
Rv0339c protein networkhttps://string-db.org/network/83332.Rv0339cRv0339c, (MTCY279.06c), len: 832 aa. Possible transcriptional regulator, showing very weak similarity with parts of others. Contains PS00017 ATP/GTP-binding site motif A (P-loop); and probable he [...]
Rv0340 protein networkhttps://string-db.org/network/83332.Rv0340Conserved protein; Rv0340, (MTCY279.07), len: 179 aa. Conserved protein; MEME-mast analysis shows similarity to product of downstream gene, Rv0341|iniB.
iniB protein networkhttps://string-db.org/network/83332.Rv0341Rv0341, (MTCY13E10.01), len: 479 aa. IniB,isoniazid-inducible gene, (see citations below). Protein very Gly-, Ala-rich, similar to cell wall proteins e.g. P27483|GRP_ARATH glycine-rich cell wall [...]
iniA protein networkhttps://string-db.org/network/83332.Rv0342Isoniazid inductible gene protein IniA; Participates in the development of tolerance to both isoniazid and ethambutol. May function through a MDR-pump like mechanism, although it does not appear [...]
iniC protein networkhttps://string-db.org/network/83332.Rv0343Rv0343, (MTCY13E10.03), len: 493 aa. IniC,isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): [...]
lpqJ protein networkhttps://string-db.org/network/83332.Rv0344cProbable lipoprotein LpqJ; Rv0344c, (MTCY13E10.04c), len: 186 aa. Probable lipoprotein, without homology. Has an appropriately positioned prokaryotic lipoprotein signature (PS00013).
Rv0345 protein networkhttps://string-db.org/network/83332.Rv0345Rv0345, (MTCY13E10.05), len: 136 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL13282 4|SCAH10_9 hypothetical protein from Streptomyces coelicolor (207 aa), FAS [...]
ansP2 protein networkhttps://string-db.org/network/83332.Rv0346cRv0346c, (MTCY13E10.06c), len: 487 aa. Possible ansP2, L-asparagine permease, integral membrane protein belonging to family containing many amino acid permeases,highly similar to G467030|B2126_F2 [...]
Rv0347 protein networkhttps://string-db.org/network/83332.Rv0347Probable conserved membrane protein; Rv0347, (MTCY13E10.07), len: 328 aa (alternative start possible). Probable conserved membrane protein,similar to Rv0831c|AL022004|MTV043_23 from Mycobacterium [...]
Rv0348 protein networkhttps://string-db.org/network/83332.Rv0348Rv0348, (MTCY13E10.08), len: 217 aa. Possible transcriptional regulator, showing some similarity to O53334|RV3188|MTV014.32 conserved hypothetical protein from Mycobacterium tuberculosis (115 aa) [...]
Rv0349 protein networkhttps://string-db.org/network/83332.Rv0349Hypothetical protein; Rv0349, (MTCY13E10.09), len: 219 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
dnaK protein networkhttps://string-db.org/network/83332.Rv0350Probable chaperone protein DnaK (heat shock protein 70) (heat shock 70 kDa protein) (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
grpE protein networkhttps://string-db.org/network/83332.Rv0351Probable GrpE protein (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK [...]
dnaJ1 protein networkhttps://string-db.org/network/83332.Rv0352Probable chaperone protein DnaJ1; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, a [...]
hspR protein networkhttps://string-db.org/network/83332.Rv0353Rv0353, (MTCY13E10.13), len: 126 aa. Probable hspR,heat shock regulatory protein (see Stewart et al., 2001),merR family, highly similar to others e.g. HspR|P40183 heat shock regulatory protein fr [...]
PPE7 protein networkhttps://string-db.org/network/83332.Rv0354cRv0354c, (MTCY13E10.14c), len: 141 aa. PPE7, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. MTCY63_9 from Mycobacterium tuberculosis (2411 aa), FASTA scores: E(): 3.6 [...]
PPE8 protein networkhttps://string-db.org/network/83332.Rv0355cPPE family protein PPE8; Rv0355c, (MTCY13E10.15c, MTCY13E10.16c,MTCY13E10.17c), len: 3300 aa. PPE8, Member of the Mycobacterium tuberculosis PPE family, similar to others e.g. AL009198|MTV004_5 f [...]
Rv0356c protein networkhttps://string-db.org/network/83332.Rv0356cConserved protein; Rv0356c, (MTCY13E10.18c), len: 214 aa. Conserved protein, equivalent to AL023514|MLCB4_12 conserved hypothetical protein from Mycobacterium leprae (218 aa),FASTA scores: opt: 1 [...]
purA protein networkhttps://string-db.org/network/83332.Rv0357cProbable adenylosuccinate synthetase PurA (imp--aspartate ligase) (ADSS) (ampsase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed [...]
Rv0358 protein networkhttps://string-db.org/network/83332.Rv0358Conserved protein; Rv0358, (MTCY13E10.20), len: 215 aa. Conserved protein, highly similar to ML0281|AL023514|MLCB4_14 conserved hypothetical protein from Mycobacterium leprae (229 aa), FASTA scor [...]
rip2 protein networkhttps://string-db.org/network/83332.Rv0359Rv0359, (MTCY13E10.21), len: 259 aa. Probable conserved integral membrane protein, highly similar to hypothetical or other membrane proteins e.g. AL133220|SCC75A_6|T50569 probable membrane protei [...]
Rv0360c protein networkhttps://string-db.org/network/83332.Rv0360cConserved protein; Rv0360c, (MTCY13E10.22c), len: 145 aa. Conserved protein, equivalent to AL023514|MLCB4_16|CAA18948.1|AL023514|MLCB4.27c hypothetical protein from Mycobacterium leprae (137 aa), [...]
Rv0361 protein networkhttps://string-db.org/network/83332.Rv0361Rv0361, (MTCY13E10.23), len: 275 aa. Probable conserved membrane protein (has hydrophobic stretch from residues 132-156), equivalent to AL023514|MLCB4_17|AA18949.1|AL023514 putative membrane prot [...]
mgtE protein networkhttps://string-db.org/network/83332.Rv0362Possible Mg2+ transport transmembrane protein MgtE; Acts as a magnesium transporter.
fba protein networkhttps://string-db.org/network/83332.Rv0363cProbable fructose-bisphosphate aldolase Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1, [...]
Rv0364 protein networkhttps://string-db.org/network/83332.Rv0364Rv0364, (MTCY13E10.26), len: 227 aa. Possible conserved transmembrane protein, equivalent to O69601|Y364_MYCLE|ML0287|CAA18951.1|AL023514|AL023514|MLCB 4_19 hypothetical 24.3 KDA protein from Myc [...]
Rv0365c protein networkhttps://string-db.org/network/83332.Rv0365cConserved protein; Rv0365c, (MTCY13E10.27c), len: 376 aa (start uncertain). Conserved protein (see citation below), very similar to G388212|CAA35191.1, a truncated ORF immediately upstream of the [...]
Rv0366c protein networkhttps://string-db.org/network/83332.Rv0366cRv0366c, (MTV036.01c), len: 197 aa. Conserved hypothetical protein, showing weak similarity to HI1395|P44173|YD95_HAEIN hypothetical protein from Haemophilus influenzae (140 aa), FASTA scores: op [...]
Rv0367c protein networkhttps://string-db.org/network/83332.Rv0367cHypothetical protein; Rv0367c, (MTV036.02c), len: 129 aa. Hypothetical unknown protein.
Rv0368c protein networkhttps://string-db.org/network/83332.Rv0368cRv0368c, (MTV036.03c), len: 403 aa. Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa), FASTA scores: opt: 341, E( [...]
Rv0369c protein networkhttps://string-db.org/network/83332.Rv0369cRv0369c, (MTV036.04c), len: 171 aa. Possible membrane protein oxidoreductase, similar to ORF 4 of the Pseudomonas thermocarboxydovorans protein of cutA-cutB-cutC gene cluster: X77931|PTC2CUTAC_4 [...]
Rv0370c protein networkhttps://string-db.org/network/83332.Rv0370cRv0370c, (MTV036.05c), len: 298 aa. Possible oxidoreductase, similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oli [...]
Rv0371c protein networkhttps://string-db.org/network/83332.Rv0371cRv0371c, (MTV036.06c), len: 197 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. AL132824|SCAH10.09c|CAB60163.1|AL132824 hypothetical protein from Streptomyces coel [...]
Rv0372c protein networkhttps://string-db.org/network/83332.Rv0372cRv0372c, (MTV036.07c), len: 251 aa. Conserved hypothetical protein, showing some similarity with CAB76248.1|X82447|COXF CoxF protein from Pseudomonas/Oligotropha carboxidovorans (280 aa); AJ22468 [...]
Rv0373c protein networkhttps://string-db.org/network/83332.Rv0373cRv0373c, (MTV036.08c), len: 799 aa. Probable carbon monoxide dehydrogenase, large chain, highly similar to others e.g. AAD00363.1| U80806|CUTL carbon monoxide dehydrogenase large subunit CutL pro [...]
Rv0374c protein networkhttps://string-db.org/network/83332.Rv0374cRv0374c, (MTV036.09c), len: 159 aa. Probable carbon monoxide dehydrogenase, small chain, highly similar to others e.g. B56279|5822285|X82447|OCCOXMSL4_2|COXS carbon-monoxide dehydrogenase small c [...]
Rv0375c protein networkhttps://string-db.org/network/83332.Rv0375cRv0375c, (MTV036.10c), len: 286 aa. Probable carbon monoxide dehydrogenase, medium chain, similar to others e.g. AAD00361.1|U80806|CUTM carbon monoxide dehydrogenase middle subunit from Hydrogeno [...]
Rv0376c protein networkhttps://string-db.org/network/83332.Rv0376cRv0376c, (MTV036.11c), len: 380 aa. Conserved hypothetical protein, highly similar to T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical protein from Streptomyces coelicolor (395 aa); and A [...]
Rv0377 protein networkhttps://string-db.org/network/83332.Rv0377Probable transcriptional regulatory protein (probably LysR-family); Rv0377, (MTV036.12), len: 321 aa. Probable transcription regulator, lysR family, showing similarity with many hypothetical tran [...]
Rv0378 protein networkhttps://string-db.org/network/83332.Rv0378Rv0378, (MTV036.13), len: 73 aa. Conserved hypothetical gly-rich protein, showing some similarity to Mycobacterium tuberculosis PE_PGRS family; also similar to MTCY06H11_16|Z85982 hypothetical gl [...]
secE2 protein networkhttps://string-db.org/network/83332.Rv0379Possible protein transport protein SecE2; Binds calcium ions. May play a role in sequestering additional small ligands; Belongs to the dodecin family.
Rv0380c protein networkhttps://string-db.org/network/83332.Rv0380cRv0380c, (MTV036.15c), len: 183 aa. Possible RNA methyltransferase, equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with [...]
Rv0381c protein networkhttps://string-db.org/network/83332.Rv0381cHypothetical protein; Rv0381c, (MTV036.16c), len: 302 aa. Hypothetical unknown protein. Equivalent to AAK44616.1 from Mycobacterium tuberculosis strain CDC1551 (254 aa) but longer 48 aa.
pyrE protein networkhttps://string-db.org/network/83332.Rv0382cProbable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of o [...]
Rv0383c protein networkhttps://string-db.org/network/83332.Rv0383cRv0383c, (MTV036.18c), len: 284 aa. Possible conserved secreted protein, with hydrophobic stretch in N-terminus and Pro-rich C-terminus. Equivalent to CAC32006.1|AL583925 possible secreted protei [...]
clpB protein networkhttps://string-db.org/network/83332.Rv0384cProbable endopeptidase ATP binding protein (chain B) ClpB (ClpB protein) (heat shock protein F84.1); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell fr [...]
Rv0385 protein networkhttps://string-db.org/network/83332.Rv0385Rv0385, (MTV036.20), len: 390 aa. Probable monooxygenase, similar to T37003|5738846|CAB52917.1|AL109949 probable flavohemoprotein from Streptomyces coelicolor (435 aa); and similar in part (C-ter [...]
Rv0386 protein networkhttps://string-db.org/network/83332.Rv0386Rv0386, (MTV036.21), len: 1085 aa. Probable regulatory protein, LuxR/uhpA family, highly similar to CAC30706.1|AL583923 possible transcriptional regulator from Mycobacterium leprae (1106 aa). Als [...]
Rv0387c protein networkhttps://string-db.org/network/83332.Rv0387cRv0387c, (MTV036.22c), len: 244 aa. Conserved hypothetical protein, showing some similarity to MTCI237.20c, and M17282|HUMEL20_1 Human elastin gene, exon 1, Elastin (687 aa), FASTA scores: opt: 1 [...]
PPE9 protein networkhttps://string-db.org/network/83332.Rv0388cRv0388c, (MTV036.23c), len: 180 aa. PPE9, Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. MTCY10G2_10|Z92539 from Mycobacterium tuberculosis (391 aa), FASTA sco [...]
purT protein networkhttps://string-db.org/network/83332.Rv0389Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-p [...]
Rv0390 protein networkhttps://string-db.org/network/83332.Rv0390Conserved protein; Rv0390, (MTCY04D9.02), len: 140 aa. Conserved protein, equivalent to AL023514|MLCB4_11|CAA18942.1|AL023514 hypothetical protein from Mycobacterium leprae (147 aa), FASTA scores [...]
metZ protein networkhttps://string-db.org/network/83332.Rv0391Probable O-succinylhomoserine sulfhydrylase MetZ (OSH sulfhydrylase); Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
ndhA protein networkhttps://string-db.org/network/83332.Rv0392cRv0392c, (MTCY04D9.04c), len: 470 aa. Probable ndhA,membrane NADH dehydrogenase, equivalent to many e.g. AF038423|AF038423_1 NADH dehydrogenase from Mycobacterium smegmatis (457 aa), FASTA scores [...]
Rv0393 protein networkhttps://string-db.org/network/83332.Rv0393Conserved 13E12 repeat family protein; Rv0393, (MTCY04D9.05), len: 441 aa. Member of Mycobacterium tuberculosis 13E12 repeat family of conserved proteins, similar to many e.g. Rv1148c, Rv1945, Rv [...]
Rv0394c protein networkhttps://string-db.org/network/83332.Rv0394cPossible secreted protein; Rv0394c, (MTCY04D9.06c), len: 239 aa. Possible secreted protein, sharing no homology with other proteins. Has hydrophobic stretch at its N-terminus.
Rv0395 protein networkhttps://string-db.org/network/83332.Rv0395Hypothetical protein; Rv0395, (MTCY04D9.07), len: 134 aa. Hypothetical unknown protein.
Rv0396 protein networkhttps://string-db.org/network/83332.Rv0396Hypothetical protein; Rv0396, (MTCY04D9.08), len: 130 aa. Hypothetical unknown protein.
Rv0397 protein networkhttps://string-db.org/network/83332.Rv0397Rv0397, (MTCY04D9.09), len: 122 aa. Part of 13E12 repeat family of conserved Mycobacterium tuberculosis proteins, similar to downstream Rv0393|Z84725|MTCY4D9_5 conserved 13E12 repeat family prote [...]
Rv0397A protein networkhttps://string-db.org/network/83332.Rv0397ARv0397A, len: 82 aa. Conserved protein.
Rv0398c protein networkhttps://string-db.org/network/83332.Rv0398cPossible secreted protein; Rv0398c, (MTCY04D9.10c), len: 213 aa. Possible secreted protein, sharing no homology with other proteins. Has potential signal sequence with hydrophobic stretch from aa [...]
lpqK protein networkhttps://string-db.org/network/83332.Rv0399cRv0399c, (MTCY04D9.11c), len: 409 aa. Possible lpqK,conserved lipoprotein, showing some similarity to penicillin binding proteins and various peptidases e.g. DAC_STRSQ|P15555 d-alanyl-d-alanine c [...]
fadE7 protein networkhttps://string-db.org/network/83332.Rv0400cAcyl-CoA dehydrogenase FadE7; Rv0400c, (MTCY04D9.12c), len: 395 aa. Probable fadE7, acyl-CoA dehydrogenase, similar to many e.g. CAC12923.1|AL445403 putative acyl CoA dehydrogenase from Streptomy [...]
Rv0401 protein networkhttps://string-db.org/network/83332.Rv0401Rv0401, (MTCY04D9.14), len: 123 aa. Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: o [...]
mmpL1 protein networkhttps://string-db.org/network/83332.Rv0402cRv0402c, (MTCY04D9.15c), len: 958 aa. Probable mmpL1, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily, highly similar to other Mycobacterial protein [...]
mmpS1 protein networkhttps://string-db.org/network/83332.Rv0403cRv0403c, (MTCY04D9.16c), len: 142 aa. Probable mmpS1, conserved membrane protein (see citation below),highly similar to other Mycobacterial proteins e.g. YV33_MYCLE|P54880 hypothetical 16.9 kDa p [...]
fadD30 protein networkhttps://string-db.org/network/83332.Rv0404Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids as acyl- adenylates (acyl-AMP), which are then transferred t [...]
pks6 protein networkhttps://string-db.org/network/83332.Rv0405Rv0405, (MTCY22G10.01), len: 1402 aa. Probable pks6,membrane-bound polyketide synthase (see citation below),highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Myc [...]
Rv0406c protein networkhttps://string-db.org/network/83332.Rv0406cRv0406c, (MTCY22G10.02c), len: 272 aa. Beta-lactamase-like protein, equivalent to AAD38170.1|AF152397_1 beta-lactamase-like protein from Mycobacterium phlei (243 aa); AL023514|MLCB4_8 hypothetica [...]
fgd1 protein networkhttps://string-db.org/network/83332.Rv0407F420-dependent glucose-6-phosphate dehydrogenase Fgd1; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate to 6-phosphogluconolactone. Appears to have a role in resistance to [...]
pta protein networkhttps://string-db.org/network/83332.Rv0408Probable phosphate acetyltransferase Pta (phosphotransacetylase); Involved in acetate metabolism; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase fami [...]
ackA protein networkhttps://string-db.org/network/83332.Rv0409Probable acetate kinase AckA (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
pknG protein networkhttps://string-db.org/network/83332.Rv0410cSerine/threonine-protein kinase PknG (protein kinase G) (STPK G); Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial r [...]
glnH protein networkhttps://string-db.org/network/83332.Rv0411cRv0411c, (MTCY22G10.07c), len: 328 aa. Probable glnH, glutamine-binding protein, membrane-bound lipoprotein (see citation below), equivalent to AL035159|MLCB1450_15|T44736|4154051|CAA22704.1 glut [...]
Rv0412c protein networkhttps://string-db.org/network/83332.Rv0412cRv0412c, (MTCY22G10.08c), len: 439 aa. Possible conserved membrane protein, equivalent to AL035159|MLCB1450_16|T44737 probable membrane protein from Mycobacterium leprae (403 aa), FASTA scores: o [...]
mutT3 protein networkhttps://string-db.org/network/83332.Rv0413Putative 8-oxo-dGTP diphosphatase 3; May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo- dGTP) from DNA and the nucl [...]
thiE protein networkhttps://string-db.org/network/83332.Rv0414cThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monopho [...]
thiO protein networkhttps://string-db.org/network/83332.Rv0415Rv0415, (MTCY22G10.12), len: 340 aa. Possible thiO,thiamine biosynthesis oxidoreductase, equivalent to T44739|4154054|CAA22708.1|AL035159|MLCB1450.24 hypothetical protein from Mycobacterium lepra [...]
thiS protein networkhttps://string-db.org/network/83332.Rv0416Possible protein ThiS; Rv0416, (MTCY22G10.13), len: 68 aa. Possible thiS protein, equivalent to T44740|4154055|CAA22709.1|AL035159|MLCB1450.25 hypothetical protein from Mycobacterium leprae (74 a [...]
thiG protein networkhttps://string-db.org/network/83332.Rv0417Probable thiamin biosynthesis protein ThiG (thiazole biosynthesis protein); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamin [...]
lpqL protein networkhttps://string-db.org/network/83332.Rv0418Probable lipoprotein aminopeptidase LpqL; An aminopeptidase; acts on free N-terminal amino groups with a very strong preference for Leu in the first position. Belongs to the peptidase M28 family. [...]
lpqM protein networkhttps://string-db.org/network/83332.Rv0419Rv0419, (MTCY22G10.16), len: 498 aa. Possible lpqM,lipoprotein peptidase; has potential N-terminal signal peptide and contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site, PS00 [...]
Rv0420c protein networkhttps://string-db.org/network/83332.Rv0420cPossible transmembrane protein; Rv0420c, (MTCY22G10.17c), len: 136 aa. Possible transmembrane protein; has potential transmembrane domains aa 53-99 and aa 100-122.
Rv0421c protein networkhttps://string-db.org/network/83332.Rv0421cConserved hypothetical protein; Rv0421c, (MTCY22G10.18c), len: 209 aa. Conserved hypothetical protein, showing similarity with NP_103507.1|14022684|BAB49293.1|AP002998 hypothetical protein from M [...]
thiD protein networkhttps://string-db.org/network/83332.Rv0422cProbable phosphomethylpyrimidine kinase ThiD (HMP-phosphate kinase) (HMP-P kinase); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Belo [...]
thiC protein networkhttps://string-db.org/network/83332.Rv0423cProbable thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl [...]
Rv0424c protein networkhttps://string-db.org/network/83332.Rv0424cHypothetical protein; Rv0424c, (MTCY22G10.21c), len: 91 aa. Hypothetical unknown protein.
ctpH protein networkhttps://string-db.org/network/83332.Rv0425cRv0425c, (MTCY22G10.22c), len: 1539 aa. Possible ctpH, metal cation-transporting P-type ATPase (transmembrane protein), showing some similarity with CAA17934.1|AL022118|13093871|CAC32203.1|AL5839 [...]
Rv0426c protein networkhttps://string-db.org/network/83332.Rv0426cPossible transmembrane protein; Rv0426c, (MTCY22G10.23c), len: 147 aa. Possible transmembrane protein; has potential transmembrane domains aa 19-41, and aa 61-83.
xthA protein networkhttps://string-db.org/network/83332.Rv0427cProbable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI); Rv0427c, (MTCY22G10.24c), len: 291 aa. Probable xthA (alternate gene name: xth), exodeoxyribonucle [...]
Rv0428c protein networkhttps://string-db.org/network/83332.Rv0428cGCN5-related N-acetyltransferase; Rv0428c, (MTCY22G10.25c), len: 302 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. [...]
def protein networkhttps://string-db.org/network/83332.Rv0429cProbable polypeptide deformylase Def (PDF) (formylmethionine deformylase); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an eff [...]
Rv0430 protein networkhttps://string-db.org/network/83332.Rv0430Rv0430, (MTCY22G10.27), len: 102 aa. Conserved hypothetical protein, equivalent to AC30882.1|AL583923 conserved hypothetical protein from Mycobacterium leprae (102 aa). Also highly similar to CAB [...]
Rv0431 protein networkhttps://string-db.org/network/83332.Rv0431Rv0431, (MTCY22G10.28), len: 164 aa. Putative tuberculin related peptide; almost identical to D00815|MSGAT103_1 AT103 from Mycobacterium tuberculosis (172 aa), FASTA score: (99.4% identity in 163 [...]
sodC protein networkhttps://string-db.org/network/83332.Rv0432Periplasmic superoxide dismutase [Cu-Zn] SodC; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial [...]
Rv0433 protein networkhttps://string-db.org/network/83332.Rv0433Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfa [...]
Rv0434 protein networkhttps://string-db.org/network/83332.Rv0434Rv0434, (MTCY22G10.31), len: 217 aa. Conserved hypothetical protein, similar to AE002052_2 from Deinococcus radiodurans (213 aa), FASTA scores: opt: 258,E(): 4e-10, (31.9% identity in 213 aa over [...]
Rv0435c protein networkhttps://string-db.org/network/83332.Rv0435cPutative conserved ATPase; Rv0435c, (MTCY22G10.32c), len: 728 aa. Putative conserved ATPase, similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocal [...]
pssA protein networkhttps://string-db.org/network/83332.Rv0436cRv0436c, (MTCY22G10.33c), len: 286 aa. Probable pssA, PS synthase (CDP-diacylglycerol--serine O-phosphatidyltransferase) (see citation below), integral membrane protein, equivalent to AL035159|ML [...]
psd protein networkhttps://string-db.org/network/83332.Rv0437cPossible phosphatidylserine decarboxylase Psd (PS decarboxylase); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
moeA2 protein networkhttps://string-db.org/network/83332.Rv0438cProbable molybdopterin biosynthesis protein MoeA2; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.
Rv0439c protein networkhttps://string-db.org/network/83332.Rv0439cRv0439c, (MTV037.03c), len: 311 aa. Probable dehydrogenase/reductase, equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, [...]
groEL2 protein networkhttps://string-db.org/network/83332.Rv044060 kDa chaperonin 2; Prevents aggregation of substrate proteins and promotes their refolding.
Rv0441c protein networkhttps://string-db.org/network/83332.Rv0441cHypothetical protein; Rv0441c, (MTV037.05c), len: 142 aa. Hypothetical unknown protein.
PPE10 protein networkhttps://string-db.org/network/83332.Rv0442cRv0442c, (MTV037.06c), len: 487 aa. PPE10, Member of the Mycobacterium tuberculosis PPE family, nearly identical to hypothetical protein from Mycobacterium tuberculosis (strain Erdman) and to AN5 [...]
Rv0443 protein networkhttps://string-db.org/network/83332.Rv0443Conserved protein; Rv0443, (MTV037.07), len: 171 aa. Conserved protein,highly similar to AL049863|SC5H1_23|T35339 hypothetical protein from Streptomyces coelicolor (171 aa), FASTA scores: opt: 56 [...]
rskA protein networkhttps://string-db.org/network/83332.Rv0444cAnti-sigma factor RskA (regulator of sigma K); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor u [...]
sigK protein networkhttps://string-db.org/network/83332.Rv0445cAlternative RNA polymerase sigma factor SigK; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasm [...]
Rv0446c protein networkhttps://string-db.org/network/83332.Rv0446cRv0446c, (MTV037.10c), len: 256 aa. Possible conserved transmembrane protein, similar at N-terminus to U1740AF|U15183|MLU15183_40 from Mycobacterium leprae (117 aa), FASTA scores: opt: 175, E(): [...]
ufaA1 protein networkhttps://string-db.org/network/83332.Rv0447cTuberculostearic acid methyltransferase UfaA1; Involved in the biosynthesis of the tuberculostearic acid (10-methylstearic-acid or TSA), a constituent lipid of the mycobacterial cell wall. Cataly [...]
Rv0448c protein networkhttps://string-db.org/network/83332.Rv0448cRv0448c, (MTV037.12c), len: 221 aa. Conserved hypothetical protein, similar to other hypothetical proteins e.g. Z74841|BOD5A2_1 from B. oleracea (283 aa),FASTA scores: opt: 257, E(): 1.4e-10, (32 [...]
Rv0449c protein networkhttps://string-db.org/network/83332.Rv0449cRv0449c, (MTV037.13c), len: 439 aa. Conserved hypothetical protein, some similarity with several hypothetical proteins and various enzymes e.g. AAK24569.1|AE005927 amine oxidase, flavin-containin [...]
mmpL4 protein networkhttps://string-db.org/network/83332.Rv0450cProbable conserved transmembrane transport protein MmpL4; Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for normal replication during the a [...]
mmpS4 protein networkhttps://string-db.org/network/83332.Rv0451cProbable conserved membrane protein MmpS4; Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence.
Rv0452 protein networkhttps://string-db.org/network/83332.Rv0452Rv0452, (MTV037.16), len: 236 aa. Possible transcriptional regulator, similar to several putative TetR-family transcriptional regulators from Streptomyces coelicolor. Also similar in N-terminus t [...]
PPE11 protein networkhttps://string-db.org/network/83332.Rv0453PPE family protein PPE11; May play an important role in the persistence of mycobacteria in host cells. May regulate the innate immune response of macrophages by promoting the production of pro-in [...]
Rv0454 protein networkhttps://string-db.org/network/83332.Rv0454Conserved hypothetical protein; Rv0454, (MTV037.18), len: 116 aa (start uncertain). Conserved hypothetical protein, showing similarity with AAA63007.1|U15183 hypothetical protein from Mycobacteri [...]
Rv0455c protein networkhttps://string-db.org/network/83332.Rv0455cConserved protein; Rv0455c, (MTV037.19c), len: 148 aa. Conserved protein, equivalent to CAC31896.1|AL583925 possible secreted protein from Mycobacterium leprae (153 aa). Has hydrophobic stretch a [...]
mazF1 protein networkhttps://string-db.org/network/83332.Rv0456APossible toxin MazF1; Toxic component of a type II toxin-antitoxin (TA) system, its cognate antitoxin is MazE1 (Probable). Probably an endoribonuclease (By similarity); Belongs to the PemK/MazF f [...]
mazE1 protein networkhttps://string-db.org/network/83332.Rv0456BPossible antitoxin MazE1; Antitoxin component of a type II toxin-antitoxin (TA) system.
echA2 protein networkhttps://string-db.org/network/83332.Rv0456cenoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0456c, (MTCI429A.02, MTV037.20c), len: 304 aa. Probable echA2, enoyl-CoA hydratase, similar to other enoy [...]
Rv0457c protein networkhttps://string-db.org/network/83332.Rv0457cProbable peptidase; Rv0457c, (MTCI429A.01, MTV038.01c), len: 673 aa. Probable peptidase, similar to many e.g. NP_102851.1|14022026|BAB48637.1 probable endopeptidase from Mesorhizobium loti (687 a [...]
Rv0458 protein networkhttps://string-db.org/network/83332.Rv0458Rv0458, (MTV038.02), len: 507 aa. Probable aldehyde dehydrogenase, highly similar to many, closest to P46369|THCA_RHOER EPTC-inducible aldehyde dehydrogenase from Rhodococcus erythropolis (506 aa [...]
Rv0459 protein networkhttps://string-db.org/network/83332.Rv0459Rv0459, (MTV038.03), len: 163 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins. Note that highly similar to products of unidentified ORFs in Xanthobacter autotrop [...]
Rv0460 protein networkhttps://string-db.org/network/83332.Rv0460Rv0460, (MTV038.04), len: 79 aa. Conserved hydrophobic protein, highly similar AAA63024.1|U15183 hypothetical protein from Mycobacterium leprae (56 aa),FASTA scores: opt: 197, E(): 3.7e-09, (63.8 [...]
Rv0461 protein networkhttps://string-db.org/network/83332.Rv0461Probable transmembrane protein; Rv0461, (MTV038.05), len: 174 aa (start uncertain). Probable transmembrane protein. Nucleotide position 552085 in the genome sequence has been corrected, A:G resul [...]
lpdC protein networkhttps://string-db.org/network/83332.Rv0462Dihydrolipoyl dehydrogenase; Lipoamide dehydrogenase is an essential component of the alpha-ketoacid dehydrogenase complexes, namely the pyruvate dehydrogenase (PDH) complex, the branched-chain a [...]
Rv0463 protein networkhttps://string-db.org/network/83332.Rv0463Rv0463, (MTV038.07), len: 97 aa. Probable conserved transmembrane protein, highly similar to AAA63017.1|U15183 hypothetical protein from Mycobacterium leprae (101 aa),FASTA scores: opt: 364, E(): [...]
Rv0464c protein networkhttps://string-db.org/network/83332.Rv0464cConserved protein; Rv0464c, (MTV038.08c), len: 190 aa. Conserved protein, highly similar to CAC31982.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (188 aa). Also some simila [...]
ramB protein networkhttps://string-db.org/network/83332.Rv0465cProbable transcriptional regulatory protein; Involved in the control of the glyoxylate cycle. RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon [...]
Rv0466 protein networkhttps://string-db.org/network/83332.Rv0466Conserved protein; Rv0466, (MTV038.10), len: 264 aa. Conserved protein,equivalent to CAC31980.1|AL583925 conserved hypothetical protein from Mycobacterium leprae (264 aa). Similar to Rv2001|Z7402 [...]
icl1 protein networkhttps://string-db.org/network/83332.Rv0467Isocitrate lyase Icl (isocitrase) (isocitratase); Involved in the persistence and virulence of M.tuberculosis. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a ke [...]
fadB2 protein networkhttps://string-db.org/network/83332.Rv04683-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD); Catalyzes the NAD-dependent oxidation of beta-hydroxybutyryl- CoA to acetoacetyl-CoA in vitro at pH 10. Al [...]
umaA protein networkhttps://string-db.org/network/83332.Rv0469Possible mycolic acid synthase UmaA; Methyltransferase that modifies short-chain fatty acids. In vitro, catalyzes the transfer of the methyl group from S-adenosyl-L- methionine (SAM) to the doubl [...]
Rv0470A protein networkhttps://string-db.org/network/83332.Rv0470ARv0470A, len: 146 aa. Hypothetical unknown protein. GC plot suggests CDS for Cys-rich protein, could possibly be continuation of Rv0471c but no frameshift found to allow this. Sequence same in My [...]
pcaA protein networkhttps://string-db.org/network/83332.Rv0470cMycolic acid synthase PcaA (cyclopropane synthase); Involved in the phagosome maturation block (PMB). Catalyzes the conversion of a double bond to a cyclopropane ring at the proximal position of [...]
Rv0471c protein networkhttps://string-db.org/network/83332.Rv0471cHypothetical protein; Rv0471c, (MTV038.15c), len: 162 aa. Hypothetical unknown protein.
Rv0472c protein networkhttps://string-db.org/network/83332.Rv0472cRv0472c, (MTV038.16c), len: 234 aa. Probable regulatory protein, possibly TetR family, equivalent to CAC31974.1|AL583925 possible TetR-family transcriptional regulator from Mycobacterium leprae ( [...]
Rv0473 protein networkhttps://string-db.org/network/83332.Rv0473Rv0473, (MTV038.17), len: 456 aa. Possible conserved transmembrane protein, showing some similarity to hypothetical proteins e.g. NP_102800.1|14021975|BAB48586.1|AP002996 hypothetical protein fro [...]
Rv0474 protein networkhttps://string-db.org/network/83332.Rv0474Rv0474, (MTV038.18), len: 140 aa. Probable transcriptional regulator, highly similar to others e.g. CAC04034.1|AL391406 putative DNA-binding protein from Streptomyces coelicolor (141 aa); N-termi [...]
hbhA protein networkhttps://string-db.org/network/83332.Rv0475Iron-regulated heparin binding hemagglutinin HbhA (adhesin); Required for extrapulmonary dissemination. Mediates adherence to epithelial cells by binding to sulfated glycoconjugates present at th [...]
Rv0476 protein networkhttps://string-db.org/network/83332.Rv0476Rv0476, (MTCY20G9.02), len: 87 aa. Possible conserved transmembrane protein, equivalent to CAC31970.1|AL583925 conserved membrane protein from Mycobacterium leprae (95 aa). Also highly similar to [...]
Rv0477 protein networkhttps://string-db.org/network/83332.Rv0477Rv0477, (MTCY20G9.03), len: 148 aa. Possible conserved secreted protein, equivalent to CAC31969.1|AL583925 hypothetical protein from Mycobacterium leprae (123 aa). Also similar to G83406|PA1914 c [...]
deoC protein networkhttps://string-db.org/network/83332.Rv0478Probable deoxyribose-phosphate aldolase DeoC (phosphodeoxyriboaldolase) (deoxyriboaldolase); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generat [...]
Rv0479c protein networkhttps://string-db.org/network/83332.Rv0479cRv0479c, (MTCY20G9.04c), len: 348 aa. Probable conserved membrane protein, equivalent to CAC31967.1|AL583925 possible secreted protein from Mycobacterium leprae (254 aa); and C-terminus highly si [...]
Rv0480c protein networkhttps://string-db.org/network/83332.Rv0480cRv0480c, (MTCY20G9.06c), len: 280 aa. Possible amidohydrolase, highly similar to NP_302587.1|NC_002677|CAC31966.1|AL583925 putative hydrolase from Mycobacterium leprae (271 aa). Also similar to o [...]
Rv0481c protein networkhttps://string-db.org/network/83332.Rv0481cHypothetical protein; Rv0481c, (MTCY20G9.07c), len: 174 aa. Hypothetical unknown protein.
murB protein networkhttps://string-db.org/network/83332.Rv0482Probable UDP-N-acetylenolpyruvoylglucosamine reductase MurB (UDP-N-acetylmuramate dehydrogenase); Cell wall formation.
lprQ protein networkhttps://string-db.org/network/83332.Rv0483Probable conserved lipoprotein LprQ; Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond bet [...]
Rv0484c protein networkhttps://string-db.org/network/83332.Rv0484cRv0484c, (MTCY20G9.10c), len: 251 aa. Probable short-chain oxidoreductase, highly similar to others e.g. T36118|4678912|CAB41284.1|AL049707 probable oxidoreductase from Streptomyces coelicolor (2 [...]
Rv0485 protein networkhttps://string-db.org/network/83332.Rv0485Possible transcriptional regulatory protein; Positively regulates the expression of PE13 and PPE18. Can also regulate expression of some other genes. Plays a role in modulation of innate immune r [...]
mshA protein networkhttps://string-db.org/network/83332.Rv0486Glycosyltransferase MshA; Catalyzes the transfer of an N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in th [...]
Rv0487 protein networkhttps://string-db.org/network/83332.Rv0487Rv0487, (MTCY20G9.13), len: 183 aa. Conserved hypothetical protein, highly similar to P54139|Y487_MYCLE|U00018_38|ML2442 hypothetical 20.8 KDA protein from Mycobacterium leprae (184 aa), FASTA sc [...]
Rv0488 protein networkhttps://string-db.org/network/83332.Rv0488Rv0488, (MTCY20G9.14), len: 201 aa. Probable conserved integral membrane protein, LysE family possibly involved in transport of Lysine, similar to others and conserved hypothetical proteins e.g. [...]
gpm1 protein networkhttps://string-db.org/network/83332.Rv0489Probable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglyc [...]
senX3 protein networkhttps://string-db.org/network/83332.Rv0490Putative two component sensor histidine kinase SenX3; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable).
regX3 protein networkhttps://string-db.org/network/83332.Rv0491Sensory transduction protein RegX3; Probably forms part of a two-component regulatory system RegX3/SenX3.
Rv0492A protein networkhttps://string-db.org/network/83332.Rv0492ARv0492A, len: 109 aa. Hypothetical unknown protein. GC plot suggests CDS.
Rv0492c protein networkhttps://string-db.org/network/83332.Rv0492cProbable oxidoreductase GMC-type; Rv0492c, (MT0511/MT0512, MTCY20G9.18c), len: 629 aa. Probable oxidoreductase GMC type, similar to others except in N-terminus e.g. P55582|AE000087_5|Y4NJ_RHISN h [...]
Rv0493c protein networkhttps://string-db.org/network/83332.Rv0493cConserved protein; Rv0493c, (MTCY20G9.19), len: 329 aa. Conserved protein, showing some similarity to U00018_33|B2168_F2_93 from Mycobacterium leprae (167 aa), FASTA scores: opt: 166,E(): 0.00077 [...]
Rv0494 protein networkhttps://string-db.org/network/83332.Rv0494Probable transcriptional regulatory protein (probably GntR-family); Rv0494, (MTCY20G9.20), len: 242 aa. Probable transcriptional regulator, GntR family, with C-terminal part highly similar to S72 [...]
Rv0495c protein networkhttps://string-db.org/network/83332.Rv0495cRv0495c, (MTCY20G9.21c), len: 296 aa. Conserved hypothetical protein, highly similar to S72915|B2168_F1_37 hypothetical protein from Mycobacterium leprae (323 aa),FASTA scores: opt: 1615, E(): 0, [...]
ppx1 protein networkhttps://string-db.org/network/83332.Rv0496Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Prefers short-chain length polyphosphates a [...]
Rv0497 protein networkhttps://string-db.org/network/83332.Rv0497Rv0497, (MTCY20G9.23), len: 310 aa. Probable conserved transmembrane protein, equivalent (but shorter in C-terminus) to P54580|Y497_MYCLE|ML2433 hypothetical 37.9 KDA protein from Mycobacterium l [...]
Rv0498 protein networkhttps://string-db.org/network/83332.Rv0498Rv0498, (MTCY20G9.24), len: 280 aa. Conserved hypothetical protein, highly similar to P54581|Y498_MYCLE|ML2432 hypothetical 30.5 KDA protein from Mycobacterium leprae (280 aa); and S72896|B2168_C [...]
Rv0499 protein networkhttps://string-db.org/network/83332.Rv0499Rv0499, (MTCY20G9.25), len: 291 aa. Conserved hypothetical protein, showing some similarity to AL031184|SC2A11_16|T34762 hypothetical protein from Streptomyces coelicolor (340 aa), FASTA scores: [...]
proC protein networkhttps://string-db.org/network/83332.Rv0500Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
Rv0500A protein networkhttps://string-db.org/network/83332.Rv0500ARv0500A, len: 78 aa. Conserved protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. U00018_25 from Mycobacterium leprae cosmid B2168 (86 aa), FASTA scores: opt: [...]
Rv0500B protein networkhttps://string-db.org/network/83332.Rv0500BRv0500B, len: 33 aa. Conserved hypothetical protein. Basic protein 18 of the 33 aa are Arg or Lys, with strong similarity to AL079345|SCE68_25 protein from Streptomyces coelicolor cosmid E6 (32 a [...]
galE2 protein networkhttps://string-db.org/network/83332.Rv0501Uncharacterized protein Rv0501; Rv0501, (MTCY20G9.28), len: 376 aa. Possible galE2,UDP-glucose 4-epimerase, highly similar (except in N-terminus) to CAC31944.1|AL583925 possible glucose epimerase [...]
Rv0502 protein networkhttps://string-db.org/network/83332.Rv0502Conserved protein; Rv0502, (MTCY20G9.29), len: 358 aa. Conserved protein, equivalent to P54878|Y502_MYCLE|ML2427 hypothetical 40.5 KDA protein from Mycobacterium leprae (367 aa), FASTA scores: op [...]
cmaA2 protein networkhttps://string-db.org/network/83332.Rv0503cCyclopropane mycolic acid synthase 2; Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proxim [...]
Rv0504c protein networkhttps://string-db.org/network/83332.Rv0504cConserved protein; Rv0504c, (MTCY20G9.31c), len: 166 aa. Conserved protein, equivalent to P54879|Y504_MYCLE|ML2425 hypothetical 18.7 KDA protein from Mycobacterium leprae (166 aa), FASTA scores: [...]
serB1 protein networkhttps://string-db.org/network/83332.Rv0505cPossible phosphoserine phosphatase SerB1 (PSP) (O-phosphoserine phosphohydrolase) (pspase); Likely catalyzes the dephosphorylation of O-phospho-L-serine into L-serine; Belongs to the HAD-like hyd [...]
mmpS2 protein networkhttps://string-db.org/network/83332.Rv0506Rv0506, (MTCY20G9.33), len: 147 aa. Probable mmpS2,conserved membrane protein (see citation below), highly similar to other Mycobacterial proteins e.g. C-terminus of AAD44232.1|AF143772_38|AF1437 [...]
mmpL2 protein networkhttps://string-db.org/network/83332.Rv0507Rv0507, (MTCY20G9.34), len: 968 aa. Probable mmpL2,conserved transmembrane transport protein (see citations below), member of RND superfamily, highly similar to other Mycobacterial proteins e.g. [...]
Rv0508 protein networkhttps://string-db.org/network/83332.Rv0508Rv0508, (MTCY20G9.35), len: 97 aa. Conserved hypothetical protein, showing similarity with T36269|5123666|CAB45355.1|AL079345 probable redoxin from Streptomyces coelicolor (101 aa), FASTA scores: [...]
hemA protein networkhttps://string-db.org/network/83332.Rv0509Probable glutamyl-tRNA reductase HemA (GLUTR); Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
hemC protein networkhttps://string-db.org/network/83332.Rv0510Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
hemD protein networkhttps://string-db.org/network/83332.Rv0511Uroporphyrinogen III methyltransferase / synthase; Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase, highly similar to others e. [...]
hemB protein networkhttps://string-db.org/network/83332.Rv0512Probable delta-aminolevulinic acid dehydratase HemB (porphobilinogen synthase) (ALAD) (ALADH); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulina [...]
Rv0513 protein networkhttps://string-db.org/network/83332.Rv0513Rv0513, (MTCY20G10.03), len: 182 aa. Possible conserved transmembrane protein, with its N-terminus highly similar to S72925|B2168_C1_182 hypothetical protein from Mycobacterium leprae (103 aa), F [...]
Rv0514 protein networkhttps://string-db.org/network/83332.Rv0514Rv0514, (MTCY20G10.04), len: 99 aa. Possible transmembrane protein.
Rv0515 protein networkhttps://string-db.org/network/83332.Rv0515Conserved 13E12 repeat family protein; Rv0515, (MTCY20G10.05), len: 503 aa. Part of M. tuberculosis 13E12 repeat family. Almost identical to Rv0336 (99.8% identity in 503 aa overlap), possibly du [...]
Rv0516c protein networkhttps://string-db.org/network/83332.Rv0516cPossible anti-anti-sigma factor; Rv0516c, (MTCY20G10.06c), len: 158 aa. Possible anti-anti-sigma factor, showing some similarity to Rv1365c|MTCY02B10_29 from Mycobacterium tuberculosis (128 aa), [...]
Rv0517 protein networkhttps://string-db.org/network/83332.Rv0517Rv0517, (MTCY20G10.07), len: 436 aa. Possible acyltransferase, integral membrane protein, equivalent (but longer 26 aa in N-terminus) to AAK44761.1|AE006954 putative acyltransferase from Mycobact [...]
Rv0518 protein networkhttps://string-db.org/network/83332.Rv0518Possible exported protein; GDSL lipase that catalyzes the hydrolysis of p-nitrophenyl (pNP) esters. pNP-decanoate (C10) is the preferred substrate. It can also use pNP-octanoate (C8), pNP-dodecan [...]
Rv0519c protein networkhttps://string-db.org/network/83332.Rv0519cRv0519c, (MTCY20G10.09c), len: 300 aa. Possible conserved membrane protein, with hydrophobic region near N-terminus. Could be a lipase. Similar to Rv0774c|MTCY369.19c|A70708 from Mycobacterium tu [...]
Rv0520 protein networkhttps://string-db.org/network/83332.Rv0520Possible methyltransferase/methylase (fragment); Rv0520, (MTCY20G10.10), len: 116 aa. Possible fragment of methyltransferase (possibly first part), highly similar to part of several methyltransfe [...]
Rv0521 protein networkhttps://string-db.org/network/83332.Rv0521Possible methyltransferase/methylase (fragment); Rv0521, (replaces MTCY20G10.11), len: 101 aa. Possible fragment of methyltransferase (possibly second part), highly similar to C-terminus of sever [...]
gabP protein networkhttps://string-db.org/network/83332.Rv0522Rv0522, (MTCY20G10.12), len: 434 aa. Probable gabP,GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Esch [...]
Rv0523c protein networkhttps://string-db.org/network/83332.Rv0523cConserved protein; Rv0523c, (MTCY25D10.02), len: 131 aa. Conserved protein, showing some similarity to M. tuberculosis proteins Rv1598c|MTCY336.06; and Rv1871c|MTCY336_06|O06592 (136 aa), FASTA s [...]
hemL protein networkhttps://string-db.org/network/83332.Rv0524Rv0524, (MTCY25D10.03), len: 462 aa. Probable hemL,glutamate-1-semialdehyde 2,1-aminomutase, equivalent to P46716|GSA_MYCLE glutamate-1-semialdehyde 2,1-aminomutase from Mycobacterium leprae (446 [...]
Rv0525 protein networkhttps://string-db.org/network/83332.Rv0525Conserved protein; Rv0525, (MTCY25D10.04), len: 202 aa. Conserved protein, equivalent to Q49821|B2168_C3_276|S72912 hypothetical protein from Mycobacterium leprae (202 aa),FASTA scores: opt: 1151 [...]
Rv0526 protein networkhttps://string-db.org/network/83332.Rv0526Rv0526, (MTCY25D10.05), len: 216 aa. Possible thioredoxin protein (thiol-disulfide interchange protein), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa) [...]
ccdA protein networkhttps://string-db.org/network/83332.Rv0527Rv0527, (MTCY25D10.06), len: 259 aa. Possible ccdA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to Q49810|B2168_C1_192|S72890 hypothetical protein from Mycobacteriu [...]
Rv0528 protein networkhttps://string-db.org/network/83332.Rv0528Rv0528, (MTCY25D10.07), len: 529 aa. Probable conserved transmembrane protein, equivalent (shorter 14 aa in N-terminus) to CAC31926.1|AL583925 conserved membrane protein from Mycobacterium leprae [...]
ccsA protein networkhttps://string-db.org/network/83332.Rv0529Rv0529, (MTCY25D10.08), len: 324 aa. Possible ccsA,cytochrome C-type biogenesis protein, integral membrane protein, equivalent to NP_302558.1|NC_002677|B2168_C3_281 possible cytochrome C biogenes [...]
Rv0530 protein networkhttps://string-db.org/network/83332.Rv0530Conserved protein; Rv0530, (MTCY25D10.09), len: 405 aa. Conserved protein, similar in part to other hypothetical proteins e.g. AL031231|SC3C3_3|CAA20252.1 from Streptomyces coelicolor (1083 aa), [...]
Rv0530A protein networkhttps://string-db.org/network/83332.Rv0530ARv0530A, len: 53 aa. Conserved protein.
Rv0531 protein networkhttps://string-db.org/network/83332.Rv0531Rv0531, (MTCY25D10.10), len: 105 aa. Possible conserved membrane protein, highly similar to Y13803|MLB1306_1|CAA74131.1 hypothetical protein from Mycobacterium leprae (86 aa), FASTA scores: E(): [...]
PE_PGRS6 protein networkhttps://string-db.org/network/83332.Rv0532PE-PGRS family protein PE_PGRS6; Rv0532, (MTCY25D10.11), len: 594 aa. PE_PGRS6,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),similar [...]
fabH protein networkhttps://string-db.org/network/83332.Rv0533c3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of t [...]
menA protein networkhttps://string-db.org/network/83332.Rv0534c1,4-dihydroxy-2-naphthoate octaprenyltransferase MenA (DHNA-octaprenyltransferase); Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Can use a variety of allylic isop [...]
pnp protein networkhttps://string-db.org/network/83332.Rv0535Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase); Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. [...]
galE3 protein networkhttps://string-db.org/network/83332.Rv0536UDP-glucose 4-epimerase GalE3; Rv0536, (MTCY25D10.15), len: 346 aa. Possible galE3,UDP-glucose 4-epimerase, highly similar to CAB76986.1|AL159178 putative epimerase from Streptomyces coelicolor ( [...]
Rv0537c protein networkhttps://string-db.org/network/83332.Rv0537cRv0537c, (MTCY25D10.16c), len: 477 aa. Probable integral membrane protein, showing weak similarity to YDNK_STRCO|P40180 hypothetical 41.2 kDa protein from Streptomyces coelicolor (411 aa), FASTA [...]
Rv0538 protein networkhttps://string-db.org/network/83332.Rv0538Rv0538, (MTCY25D10.17), len: 548 aa. Possible conserved membrane protein. Middle region highly similar to AAB63811.1|AF009829|MBE4863a|O32850 unknown protein from Mycobacterium bovis (295 aa) pos [...]
Rv0539 protein networkhttps://string-db.org/network/83332.Rv0539Uncharacterized glycosyltransferase Rv0539; Rv0539, (MTCY25D10.18), len: 210 aa. Probable dolichol-P-sugar synthase, highly similar to CAB76989.1|AL159178 putative glycosyltransferase from Strept [...]
Rv0540 protein networkhttps://string-db.org/network/83332.Rv0540Rv0540, (MTCY25D10.19), len: 220 aa. Conserved hypothetical protein, similar to hypothetical proteins from Streptomyces coelicolor: CAB76990.1|AL159178 (213 aa); N-terminus of BAA84086.1|AB032065 [...]
Rv0541c protein networkhttps://string-db.org/network/83332.Rv0541cRv0541c, (MTCY25D10.20c), len: 449 aa. Probable conserved integral membrane protein, highly similar (except first 40 residues) to CAB76994.1|AL159178 putative integral membrane protein from Strep [...]
menE protein networkhttps://string-db.org/network/83332.Rv0542cProbable 2-succinylbenzoate--CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). May be involved in the biosynthesis of menaquinone (By similarity).
Rv0543c protein networkhttps://string-db.org/network/83332.Rv0543cConserved protein; Rv0543c, (MTCY25D10.22c), len: 100 aa. Conserved protein, equivalent to Q50171|MLU15187_32|NP_302469.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (100 a [...]
Rv0544c protein networkhttps://string-db.org/network/83332.Rv0544cRv0544c, (MTCY25D10.23c), len: 92 aa. Possible conserved transmembrane protein, equivalent to NP_302470.1|NC_002677 possible membrane protein from Mycobacterium leprae (96 aa); and shows some sim [...]
pitA protein networkhttps://string-db.org/network/83332.Rv0545cProbable low-affinity inorganic phosphate transporter integral membrane protein PitA; Low-affinity inorganic phosphate transport.
Rv0546c protein networkhttps://string-db.org/network/83332.Rv0546cConserved protein; Rv0546c, (MTCY25D10.25c), len: 128 aa. Conserved protein, equivalent to AAA63111.1|U15187|Q50174|U296X hypothetical protein from Mycobacterium leprae (144 aa),FASTA scores: opt [...]
Rv0547c protein networkhttps://string-db.org/network/83332.Rv0547cPossible oxidoreductase; Rv0547c, (MTCY25D10.26c), len: 294 aa. Possible oxidoreductase, similar to various oxidoreductases e.g. fatty acyl-CoA reductase from Acinetobacter calcoaceticus (295 aa) [...]
menB protein networkhttps://string-db.org/network/83332.Rv0548cNaphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase); Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hy [...]
vapC3 protein networkhttps://string-db.org/network/83332.Rv0549cPossible toxin VapC3; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized [...]
vapB3 protein networkhttps://string-db.org/network/83332.Rv0550cPossible antitoxin VapB3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC3.
fadD8 protein networkhttps://string-db.org/network/83332.Rv0551cRv0551c, (MTCY25D10.30c), len: 571 aa. Probable fadD8, fatty-acid-CoA synthetase, similar to many e.g. LCFA_ECOLI|P29212 long-chain-fatty-acid--CoA ligase (561 aa), FASTA scores: opt: 585, E(): 9 [...]
Rv0552 protein networkhttps://string-db.org/network/83332.Rv0552Conserved protein; Rv0552, (MTCY25D10.31), len: 534 aa. Conserved protein, similar to others from several organisms. Also shows some similarity with regulatory proteins e.g. AEPA_ERWCA|Q06555 exo [...]
menC protein networkhttps://string-db.org/network/83332.Rv0553Probable muconate cycloisomerase MenC (cis,cis-muconate lactonizing enzyme) (MLE); Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB); Belongs to [...]
bpoC protein networkhttps://string-db.org/network/83332.Rv0554Rv0554, (MTCY25D10.33), len: 262 aa. Possible bpoC,peroxidase (non-haem peroxidase), equivalent to NP_302477.1|NC_002677 putative hydrolase from Mycobacterium leprae (265 aa). Also highly similar [...]
menD protein networkhttps://string-db.org/network/83332.Rv05552-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resultin [...]
Rv0556 protein networkhttps://string-db.org/network/83332.Rv0556Rv0556, (MTCY25D10.35), len: 171 aa. Probable conserved transmembrane protein, equivalent to NP_302479.1|NC_002677 putative membrane protein from Mycobacterium leprae (175 aa). A core mycobacteri [...]
mgtA protein networkhttps://string-db.org/network/83332.Rv0557Mannosyltransferase MgtA; Catalyzes the addition of a mannose residue from GDP-D- mannose to GlcAGroAc2 to generate 1,2-di-O-C16/C18:1-(alpha-D- mannopyranosyl)-(1-4)-(alpha-D-glucopyranosyluroni [...]
menH protein networkhttps://string-db.org/network/83332.Rv0558Demethylmenaquinone methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2); Belongs to the class I-like SAM-binding methyltransferase [...]
Rv0559c protein networkhttps://string-db.org/network/83332.Rv0559cRv0559c, (MTCY25D10.38c), len: 112 aa. Possible conserved secreted protein, similar to NP_302481.1|NC_002677 putative secreted protein from Mycobacterium leprae (112 aa). Also similar to Y08B_MYC [...]
Rv0560c protein networkhttps://string-db.org/network/83332.Rv0560cRv0560c, (MTCY25D10.39c), len: 241 aa. Possible benzoquinone methyltransferase (see citation below),similar to other hypothetical proteins and methyltransferases e.g. Q54300 methyltransferase (21 [...]
menJ protein networkhttps://string-db.org/network/83332.Rv0561cPossible oxidoreductase; Catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in M.tuberculosis, likely the beta-isoprene unit, forming the predominant for [...]
grcC1 protein networkhttps://string-db.org/network/83332.Rv0562Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase); Rv0562, (MTCY25D10.41), len: 335 aa. Probable grcC1,polyprenyl diphosphate synthetase, equivalent to NP_30248 [...]
htpX protein networkhttps://string-db.org/network/83332.Rv0563Rv0563, (MTV039.01, MTCY25D10.42), len: 286 aa. (alternative start at position 654006). Probable htpX,protease heat shock protein X (transmembrane protein),equivalent to NP_302484.1|NC_002677 put [...]
gpdA1 protein networkhttps://string-db.org/network/83332.Rv0564cProbable glycerol-3-phosphate dehydrogenase 2 [NAD(P)+]; Rv0564c, (MTV039.02c), len: 341 aa. Possible gpdA1(alternate gene names: gpsA, glyC),glycerol-3-phosphate dehydrogenase [NAD(P)+] dependen [...]
Rv0565c protein networkhttps://string-db.org/network/83332.Rv0565cRv0565c, (MTV039.03c), len: 486 aa. Probable monoxygenase, highly similar to NP_301173.1|NC_002677 putative monooxygenase from Mycobacterium leprae (494 aa). Also highly similar to others e.g. NP [...]
Rv0566c protein networkhttps://string-db.org/network/83332.Rv0566cConserved protein; Rv0566c, (MTV039.04c), len: 163 aa. Conserved protein, similar to others e.g. P77482|YAJQ_ECOLI hypothetical 19.0 KDa protein from Escherichia coli (169 aa), FASTA scores: opt: [...]
Rv0567 protein networkhttps://string-db.org/network/83332.Rv0567Rv0567, (MTV039.05), len: 339 aa. Probable methyltransferase, similar to several e.g. P39896|TCMO_STRGA tetracenomycin polyketide synthesis 8-O-methyltransferase from Streptomyces glaucescens (33 [...]
cyp135B1 protein networkhttps://string-db.org/network/83332.Rv0568Rv0568, (MT0594, MTV039.06), len: 472 aa. Possible cyp135B1, cytochrome P450, similar to putative cytochrome P-450 monoxygenases and other cytochrome P-450 related enzymes e.g. P29980|CPXN_ANASP [...]
Rv0569 protein networkhttps://string-db.org/network/83332.Rv0569Conserved protein; Rv0569, (MTV039.07), len: 88 aa. Conserved protein. C-terminus highly similar to AAA63065.1|U15184|MLU15184_10 hypothetical protein from Mycobacterium leprae (53 aa),FASTA scor [...]
nrdZ protein networkhttps://string-db.org/network/83332.Rv0570Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleoti [...]
Rv0571c protein networkhttps://string-db.org/network/83332.Rv0571cConserved protein; Rv0571c, (MTV039.09c), len: 443 aa. Conserved protein, highly similar to the products of two adjacent orfs in Mycobacterium leprae: AAA63059.1|U15184|U650S|Q50111 hypothetical [...]
Rv0572c protein networkhttps://string-db.org/network/83332.Rv0572cHypothetical protein; Rv0572c, (MTV039.10c), len: 113 aa. Hypothetical unknown protein.
pncB2 protein networkhttps://string-db.org/network/83332.Rv0573cNicotinic acid phosphoribosyltransferase PncB2; Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) invol [...]
Rv0574c protein networkhttps://string-db.org/network/83332.Rv0574cConserved hypothetical protein; Could be involved in the biosynthesis, transport or localization of poly-alpha-L-glutamine (PLG), a cell wall component. Contributes to stress tolerance and virule [...]
Rv0575c protein networkhttps://string-db.org/network/83332.Rv0575cRv0575c, (MTV039.13c), len: 388 aa. Possible oxidoreductase, similar to many diverse oxidoreductases and monooxygenases e.g. AL109974|SCF34_5|T36404 probable monooxygenase from Streptomyces coeli [...]
Rv0576 protein networkhttps://string-db.org/network/83332.Rv0576Probable transcriptional regulatory protein (possibly ArsR-family); Rv0576, (MTV039.14), len: 434 aa. Probable transcriptional regulator, ArsR family. N-terminus highly similar to others e.g. NP_ [...]
TB27.3 protein networkhttps://string-db.org/network/83332.Rv0577Conserved protein TB27.3; May function as a glyoxylase involved in the methylglyoxal detoxification pathway. Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased ex [...]
PE_PGRS7 protein networkhttps://string-db.org/network/83332.Rv0578cPE-PGRS family protein PE_PGRS7; Rv0578c, (MTV039.16c), len: 1306 aa. PE_PGRS7,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly [...]
Rv0579 protein networkhttps://string-db.org/network/83332.Rv0579Rv0579, (MTV039.17), len: 252 aa. Conserved hypothetical protein, showing some similarity to others e.g. AE001747_4 hypothetical protein from Thermotoga maritima (247 aa), FASTA scores: opt: 612, [...]
Rv0580c protein networkhttps://string-db.org/network/83332.Rv0580cConserved protein; Rv0580c, (MTV039.18c), len: 163 aa. Conserved protein, equivalent to AAA90989.1|U20446|MK35 lipoprotein precursor from Mycobacterium kansasii (225 aa).
vapB26 protein networkhttps://string-db.org/network/83332.Rv0581Possible antitoxin VapB26; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC26.
vapC26 protein networkhttps://string-db.org/network/83332.Rv0582Possible toxin VapC26. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
lpqN protein networkhttps://string-db.org/network/83332.Rv0583cRv0583c, (MTV039.21c), len: 228 aa. Probable lpqN,conserved lipoprotein, equivalent to AAA90989.1|U20446|MK35|U20446|MKU20446_1 lipoprotein precursor from Mycobacterium kansasii (225 aa), FASTA s [...]
Rv0584 protein networkhttps://string-db.org/network/83332.Rv0584Rv0584, (MTV039.22), len: 877 aa. Possible conserved exported protein, similar to other hypothetical proteins which are not necessarily secreted e.g. CAB61925.1|AL133278 putative secreted protein [...]
Rv0585c protein networkhttps://string-db.org/network/83332.Rv0585cRv0585c, (MTV039.23c, MTCY19H5.37), len: 795 aa. Probable conserved integral membrane protein. C-terminus similar to CAB88984.1|AL353864 putative integral membrane protein from Streptomyces coeli [...]
mce2R protein networkhttps://string-db.org/network/83332.Rv0586Probable transcriptional regulatory protein Mce2R (GntR-family); Negatively regulates the expression of its operon as well as expression of end (endonuclease 4).
yrbE2A protein networkhttps://string-db.org/network/83332.Rv0587Rv0587, (MTCY19H5.35c), len: 265 aa. YrbE2A,hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tu [...]
yrbE2B protein networkhttps://string-db.org/network/83332.Rv0588Rv0588, (MTCY19H5.34c), len: 295 aa. YrbE2B,hypothetical unknown integral membrane protein, part of mce2 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tu [...]
mce2A protein networkhttps://string-db.org/network/83332.Rv0589Mce-family protein Mce2A; Rv0589, (MTCY19H5.33c), len: 404 aa. Mce2A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium t [...]
mce2B protein networkhttps://string-db.org/network/83332.Rv0590Mce-family protein Mce2B; Rv0590, (MTCY19H5.32c), len: 275 aa. Mce2B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium t [...]
Rv0590A protein networkhttps://string-db.org/network/83332.Rv0590AMce-family related protein; Rv0590A, len: 84 aa. Probable continuation of mce2B|Rv0590. Can find no frameshift to account for this. Possible nucleotide G missing at 688793 as there are 5 in Mycob [...]
mce2C protein networkhttps://string-db.org/network/83332.Rv0591Mce-family protein Mce2C; Rv0591, (MTCY19H5.31c), len: 481 aa. Mce2C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium t [...]
mce2D protein networkhttps://string-db.org/network/83332.Rv0592Mce-family protein Mce2D; Rv0592, (MTCY19H5.30c), len: 508 aa. Mce2D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium t [...]
lprL protein networkhttps://string-db.org/network/83332.Rv0593Rv0593, (MTCY19H5.29c), len: 402 aa. Possible lprL (alternate gene name: mce2E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), high [...]
mce2F protein networkhttps://string-db.org/network/83332.Rv0594Mce-family protein Mce2F; Rv0594, (MTCY19H5.28c), len: 516 aa. Mce2F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tubercul [...]
vapC4 protein networkhttps://string-db.org/network/83332.Rv0595cPossible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA [...]
vapB4 protein networkhttps://string-db.org/network/83332.Rv0596cPossible antitoxin VapB4; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate VapC4 toxin. Upon expression in situ, in M.smegmatis o [...]
Rv0597c protein networkhttps://string-db.org/network/83332.Rv0597cRv0597c, (MTCY19H5.25), len: 411 aa. Conserved hypothetical protein, highly similar to Rv3179 conserved hypothetical protein from Mycobacterium tuberculosis (429 aa). Also similar to AAF76191.1|A [...]
vapC27 protein networkhttps://string-db.org/network/83332.Rv0598cPossible toxin VapC27. Contains PIN domain; Probably the toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Its cognate antitoxin is VapB27. Belongs to the PINc/V [...]
vapB27 protein networkhttps://string-db.org/network/83332.Rv0599cPossible antitoxin VapB27; Antitoxin component of a type II toxin-antitoxin (TA) system. Cognate toxin is VapC27. Upon expression in E.coli partially counteracts the ribonuclease activity of non- [...]
Rv0600c protein networkhttps://string-db.org/network/83332.Rv0600cTwo component sensor kinase [second part]; Member of the three-protein two-component system HK1/HK2/TcrA. Kinase that binds ATP and catalyzes the transfer of a phosphoryl group from ATP to HK2.
Rv0601c protein networkhttps://string-db.org/network/83332.Rv0601cTwo component sensor kinase [first part]; Member of the three-protein two-component system HK1/HK2/TcrA. HK2 transfers its phosphoryl group to TcrA.
tcrA protein networkhttps://string-db.org/network/83332.Rv0602cTwo component DNA binding transcriptional regulatory protein TcrA; Member of the three-protein two-component system HK1/HK2/TcrA.
Rv0603 protein networkhttps://string-db.org/network/83332.Rv0603Possible exported protein; Rv0603, (MTCY19H5.19c), len: 103 aa. Possible exported protein with hydrophobic stretch at aa 7-29. This region is a possible MT-complex-specific genomic island (See Be [...]
lpqO protein networkhttps://string-db.org/network/83332.Rv0604Rv0604, (MTCY19H5.18c), len: 316 aa. Probable lpqO,conserved lipoprotein, highly similar to Rv2999|lppY putative lipoprotein from Mycobacterium tuberculosis (321 aa), FASTA scores: opt: 1153, E() [...]
Rv0605 protein networkhttps://string-db.org/network/83332.Rv0605Possible resolvase; Rv0605, (MTCY19H5.17c), len: 202 aa. Possible resolvase for IS_Y349 element, similar to several Mycobacterial hypothetical proteins and weakly similar to Q52563 resolvase from [...]
Rv0606 protein networkhttps://string-db.org/network/83332.Rv0606Possible transposase (fragment); Rv0606, (MTCY19H5.16c), len: 247 aa. Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tub [...]
Rv0607 protein networkhttps://string-db.org/network/83332.Rv0607Hypothetical protein; Rv0607, (MTCY19H5.15c), len: 128 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
vapB28 protein networkhttps://string-db.org/network/83332.Rv0608Possible antitoxin VapB28; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC28.
vapC28 protein networkhttps://string-db.org/network/83332.Rv0609Possible toxin VapC28. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv0609A protein networkhttps://string-db.org/network/83332.Rv0609ARv0609A, len: 75 aa. Conserved hypothetical protein,highly similar to part of upstream ORF Rv0612|MTCY19H5.09c conserved hypothetical protein from Mycobacterium tuberculosis (201 aa), FASTA score [...]
Rv0610c protein networkhttps://string-db.org/network/83332.Rv0610cHypothetical protein; Rv0610c, (MTCY19H5.11), len: 385 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv0611c protein networkhttps://string-db.org/network/83332.Rv0611cHypothetical protein; Rv0611c, (MTCY19H5.10), len: 127 aa. Hypothetical unknown protein. Note that first start has been taken although this overlaps slightly with the upstream ORF. This region is [...]
Rv0612 protein networkhttps://string-db.org/network/83332.Rv0612Rv0612, (MTCY19H5.09c), len: 201 aa. Conserved hypothetical protein, highly similar, but in part, to downstream ORF Rv0609A conserved hypothetical protein from Mycobacterium tuberculosis (75 aa); [...]
Rv0613c protein networkhttps://string-db.org/network/83332.Rv0613cUnknown protein; Rv0613c, (MTCY19H5.08), len: 855 aa. Unknown protein. Contains a very short region with strong similarity to several preprotein translocases e.g. P47847|SECA_LISMO preprotein tra [...]
Rv0614 protein networkhttps://string-db.org/network/83332.Rv0614Rv0614, (MTCY19H5.07c), len: 330 aa. Conserved hypothetical protein, similar in part to Mycobacterium tuberculosis hypothetical proteins e.g. YY16_MYCTU|Q10685|Rv2077c|MT2137|MTCY49.16c conserved [...]
Rv0615 protein networkhttps://string-db.org/network/83332.Rv0615Rv0615, (MTCY19H5.06c), len: 80 aa. Probable integral membrane protein.
vapB29 protein networkhttps://string-db.org/network/83332.Rv0616APossible antitoxin VapB29; Possibly the antitoxic component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC29.
Rv0616c protein networkhttps://string-db.org/network/83332.Rv0616cHypothetical protein; Rv0616c, (MTCY19H5.05), len: 88 aa. Hypothetical unknown protein.
vapC29 protein networkhttps://string-db.org/network/83332.Rv0617Possible toxin VapC29. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is VapB29 (By similarity). Has ribonuclease activity.
galTa protein networkhttps://string-db.org/network/83332.Rv0618Rv0618, (MTCY19H5.03c), len: 231 aa (probable partial CDS). Probable galTa, first part of galactose-1-phosphate uridylyltransferase, highly similar to N-terminal half of other galT proteins e.g. [...]
galTb protein networkhttps://string-db.org/network/83332.Rv0619Rv0619, (MTCY19H5.02c), len: 181 aa (probable partial CDS). Probable galTb, second part of galactose-1-phosphate uridylyltransferase, highly similar to C-terminal half of other galT proteins e.g. [...]
galK protein networkhttps://string-db.org/network/83332.Rv0620Probable galactokinase GalK (galactose kinase); Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Rv0621 protein networkhttps://string-db.org/network/83332.Rv0621Possible membrane protein; Rv0621, (MTCY20H10.02), len: 354 aa. Possible membrane protein; contains potential membrane spanning regions. Also contains PS00017 ATP/GTP-binding site motif A (P-loop [...]
Rv0622 protein networkhttps://string-db.org/network/83332.Rv0622Possible membrane protein; Rv0622, (MTCY20H10.03), len: 315 aa. Possible membrane protein; contains potential membrane spanning region. Shows weak similarity with Mycobacterium tuberculosis hypot [...]
vapB30 protein networkhttps://string-db.org/network/83332.Rv0623Possible antitoxin VapB30; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC30.
vapC30 protein networkhttps://string-db.org/network/83332.Rv0624Possible toxin VapC30. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv0625c protein networkhttps://string-db.org/network/83332.Rv0625cRv0625c, (MTCY20H10.06c), len: 246 aa. Probable conserved transmembrane protein, showing similarity with others e.g. CAB61866.1|AL133252 putative integral membrane protein from Streptomyces coeli [...]
vapB5 protein networkhttps://string-db.org/network/83332.Rv0626Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5.
vapC5 protein networkhttps://string-db.org/network/83332.Rv0627Possible toxin VapC5; Probable toxic component of a type II toxin-antitoxin (TA) system. The cognate antitoxin is VapB5. Has limited RNase activity on substrates; activity is seen with a VapC5-Va [...]
Rv0628c protein networkhttps://string-db.org/network/83332.Rv0628cConserved hypothetical protein; Rv0628c, (MTCY20H10.09c), len: 383 aa. Conserved hypothetical protein, highly similar to Rv0874c|YZ02_MYCTU|Q10536 conserved hypothetical protein from Mycobacteriu [...]
recD protein networkhttps://string-db.org/network/83332.Rv0629cRecBCD enzyme subunit RecD; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidi [...]
recB protein networkhttps://string-db.org/network/83332.Rv0630cRecBCD enzyme subunit RecB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidi [...]
recC protein networkhttps://string-db.org/network/83332.Rv0631cRecBCD enzyme subunit RecC; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidi [...]
echA3 protein networkhttps://string-db.org/network/83332.Rv0632cProbable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0632c, (MTCY20H10.13c), len: 231 aa. Probable echA3, enoyl-CoA hydratase, almost identical to th [...]
Rv0633c protein networkhttps://string-db.org/network/83332.Rv0633cPossible exported protein; Rv0633c, (MTCY20H11.14c), len: 279 aa. Possible exported protein; has hydrophobic stretch at aa 23-41.
Rv0634A protein networkhttps://string-db.org/network/83332.Rv0634ARv0634A, len: 83 aa. Unknown protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
rpmG2 protein networkhttps://string-db.org/network/83332.Rv0634BRv0634B, len: 55 aa. rpmG2, 50S ribosomal protein L33. Note that Mycobacterium tuberculosis has a second rpmG gene: P96925|R33H_MYCTU|Rv2057c|MTCY63A.03|rpmG1 putative 50S ribosomal protein L33 ( [...]
Rv0634c protein networkhttps://string-db.org/network/83332.Rv0634cPossible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II); Rv0634c, (MTCY20H10.15c), len: 237 aa. Possible glyoxalase II, equivalent to NP_302290.1|NC_002677 putative glyoxylase II from [...]
hadA protein networkhttps://string-db.org/network/83332.Rv0635Rv0635, (MTCY20H10.16), len: 158 aa. HadA,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent to NP_302287.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (159 aa); and high [...]
hadB protein networkhttps://string-db.org/network/83332.Rv0636Rv0636, (MTCY20H10.17), len: 142 aa. HadB,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent to NP_302286.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (142 aa). Shows st [...]
hadC protein networkhttps://string-db.org/network/83332.Rv0637Rv0637, (MTCY20H10.18), len: 166 aa. HadC,(3R)-hydroxyacyl-ACP dehydratase subunit, equivalent to NP_302285.1|NC_002677|YV31_MYCLE|P54879 conserved hypothetical protein from Mycobacterium leprae [...]
secE1 protein networkhttps://string-db.org/network/83332.Rv0638Probable preprotein translocase SecE1; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
nusG protein networkhttps://string-db.org/network/83332.Rv0639Probable transcription antitermination protein NusG; Participates in transcription elongation, termination and antitermination; Belongs to the NusG family.
rplK protein networkhttps://string-db.org/network/83332.Rv064050S ribosomal protein L11 RplK; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
rplA protein networkhttps://string-db.org/network/83332.Rv064150S ribosomal protein L1 RplA; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
mmaA4 protein networkhttps://string-db.org/network/83332.Rv0642cHydroxymycolate synthase MmaA4; Involved in the biosynthesis of hydroxymycolate, a common precursor of oxygenated mycolic acids (methoxy-mycolate and keto- mycolate). Probably transfers a methyl [...]
mmaA3 protein networkhttps://string-db.org/network/83332.Rv0643cMethoxy mycolic acid synthase MmaA3; Involved in the biosynthesis of methoxymycolic acid. It catalyzes the O-methylation of the hydroxy group of the hydroxymycolate to form a methyl ether; Belong [...]
mmaA2 protein networkhttps://string-db.org/network/83332.Rv0644cCyclopropane mycolic acid synthase MmaA2; Catalyzes the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene grou [...]
mmaA1 protein networkhttps://string-db.org/network/83332.Rv0645cMycolic acid methyltransferase MmaA1; Involved in the conversion of a cis-olefin into a trans- olefin with concomitant introduction of an allylic methyl branch at the proximal position of the pre [...]
lipG protein networkhttps://string-db.org/network/83332.Rv0646cRv0646c, (MTCY20H10.27c), len: 301 aa. Probable lipG, lipase/esterase, equivalent to NP_302278.1|NC_002677 probable hydrolase from Mycobacterium leprae (304 aa). Also highly similar to various hy [...]
Rv0647c protein networkhttps://string-db.org/network/83332.Rv0647cConserved protein; Rv0647c, (MTCY20H10.28c), len: 488 aa. Conserved protein, equivalent to NP_302277.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (448 aa). Also showing si [...]
Rv0648 protein networkhttps://string-db.org/network/83332.Rv0648Alpha-mannosidase; Rv0648, (MTCY20H10.29), len: 1215 aa. Alpha-mannosidase (see citation below), showing some similarity to hypothetical proteins and various sugar hydrolases e.g. SYCSLRA_6|Q5552 [...]
fabD2 protein networkhttps://string-db.org/network/83332.Rv0649Rv0649, (MTCY20H10.30), len: 224 aa. Possible fabD2,malonyl CoA-acyl carrier protein transacylase, similar to mtfabd|FABD_MYCTU|Q10501|Rv2243 malonyl CoA-acyl carrier protein transacylase from My [...]
Rv0650 protein networkhttps://string-db.org/network/83332.Rv0650Possible sugar kinase; Rv0650, (MTCY20H10.31), len: 302 aa. Possible sugar kinase, highly similar to others e.g. CAB95296.1|AL359779 putative sugar kinase from Streptomyces coelicolor (317 aa); N [...]
rplJ protein networkhttps://string-db.org/network/83332.Rv065150S ribosomal protein L10 RplJ; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
rplL protein networkhttps://string-db.org/network/83332.Rv065250S ribosomal protein L7/L12 RplL (SA1); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belong [...]
Rv0653c protein networkhttps://string-db.org/network/83332.Rv0653cPossible transcriptional regulatory protein (probably TetR-family); Rv0653c, (MTCI376.23, MTCY20H10.34c), len: 231 aa. Possible transcriptional regulator, TetR family, similar in N-terminus to ot [...]
Rv0654 protein networkhttps://string-db.org/network/83332.Rv0654Probable dioxygenase; Catalyzes the oxidative cleavage of several carotenoids and apocarotenoids in vitro. In contrast to other carotenoid oxygenases, cleaves substrates at two different sites, n [...]
mkl protein networkhttps://string-db.org/network/83332.Rv0655Possible ribonucleotide-transport ATP-binding protein ABC transporter Mkl; Not known, could be involved in the transport of ribonucleotides.
vapC6 protein networkhttps://string-db.org/network/83332.Rv0656cPossible toxin VapC6; Toxic component of a type II type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB6 (By similarity). Belongs to the PINc/VapC protein family.
vapB6 protein networkhttps://string-db.org/network/83332.Rv0657cPossible antitoxin VapB6; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC6.
Rv0658c protein networkhttps://string-db.org/network/83332.Rv0658cRv0658c, (MTCI376.18), len: 238 aa. Probable conserved integral membrane protein, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and showing some [...]
mazF2 protein networkhttps://string-db.org/network/83332.Rv0659cToxin MazF2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli partially inhibits cell growth after one cell generation. Its cognate antitoxin is MazE2. Probably [...]
mazE2 protein networkhttps://string-db.org/network/83332.Rv0660cPossible antitoxin MazE2; Antitoxin component of a type II toxin-antitoxin (TA) system.
vapC7 protein networkhttps://string-db.org/network/83332.Rv0661cPossible toxin VapC7; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB7 (By similarity). Belongs to the PINc/VapC protein family.
vapB7 protein networkhttps://string-db.org/network/83332.Rv0662cPossible antitoxin VapB7; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC7.
atsD protein networkhttps://string-db.org/network/83332.Rv0663Rv0663, (MTCI376.13c), len: 787 aa. Possible atsD,arylsulfatase, similar to others e.g. P5169|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 653, E(): 0, (33.1% [...]
vapB8 protein networkhttps://string-db.org/network/83332.Rv0664Possible antitoxin VapB8; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC8.
vapC8 protein networkhttps://string-db.org/network/83332.Rv0665Possible toxin VapC8; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB8 (By similarity); Belongs to the PINc/VapC protein family.
Rv0666 protein networkhttps://string-db.org/network/83332.Rv0666Possible membrane protein; Rv0666, (MTCI376.10c), len: 57 aa. Possible membrane protein; has hydrophobic stretch at aa 29-47. This region is a possible MT-complex-specific genomic island (See Bec [...]
rpoB protein networkhttps://string-db.org/network/83332.Rv0667DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rpoC protein networkhttps://string-db.org/network/83332.Rv0668DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Rv0669c protein networkhttps://string-db.org/network/83332.Rv0669cPossible hydrolase; Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid. Also catalyzes the synthesis of Cers from Sph and fatty ac [...]
end protein networkhttps://string-db.org/network/83332.Rv0670Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase); Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating [...]
lpqP protein networkhttps://string-db.org/network/83332.Rv0671Rv0671, (MTCI376.03c), len: 280 aa. Possible lpqP,conserved lipoprotein, similar to U00012|B1308_F2_43|Q49658 from Mycobacterium leprae (302 aa), FASTA scores: opt: 449,E(): 2.4e-22, (37.6% ident [...]
fadE8 protein networkhttps://string-db.org/network/83332.Rv0672Rv0672, (MTCI376.02c), len: 542 aa. Probable fadE8,acyl-CoA dehydrogenase, highly similar to many e.g. CAC33951.1|AL589708 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (557 aa); P [...]
echA4 protein networkhttps://string-db.org/network/83332.Rv0673Possible enoyl-CoA hydratase EchA4 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0673, (MTCI376.01c, MTV040.01), len: 312 aa. Possible echA4, enoyl-CoA hydratase, showing simila [...]
Rv0674 protein networkhttps://string-db.org/network/83332.Rv0674Rv0674, (MTV040.02), len: 240 aa. Conserved hypothetical protein, highly similar to AC13063.1|AL445503 conserved hypothetical protein from Streptomyces coelicolor (268 aa); and similar to NP_4381 [...]
echA5 protein networkhttps://string-db.org/network/83332.Rv0675Probable enoyl-CoA hydratase EchA5 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0675, (MTV040.03), len: 263 aa. Probable echA5,enoyl-CoA hydratase, similar to several e.g. NP_2 [...]
mmpL5 protein networkhttps://string-db.org/network/83332.Rv0676cProbable conserved transmembrane transport protein MmpL5; Part of an export system, which is required for biosynthesis and secretion of siderophores.
mmpS5 protein networkhttps://string-db.org/network/83332.Rv0677cPossible conserved membrane protein MmpS5; Part of an export system, which is required for biosynthesis and secretion of siderophores. Essential for virulence. Belongs to the MmpS family.
mmpR5 protein networkhttps://string-db.org/network/83332.Rv0678Conserved protein; Controls the expression level of the Mmps2-MmpL2, MmpS4- MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter re [...]
Rv0679c protein networkhttps://string-db.org/network/83332.Rv0679cRv0679c, (MTV040.07c), len: 165 aa. Conserved Thr-rich protein, similar in part to neighboring ORF Rv0680c (124 aa), FASTA score: (35.1% identity in 131 aa overlap); and Rv0314c (220 aa). Predict [...]
Rv0680c protein networkhttps://string-db.org/network/83332.Rv0680cRv0680c, (MTV040.08c), len: 124 aa. Possible conserved transmembrane protein, showing similarity with C-terminal part of Rv0314c|Z96800|MTCY63.19c conserved hypothetical protein from Mycobacteriu [...]
Rv0681 protein networkhttps://string-db.org/network/83332.Rv0681Probable transcriptional regulatory protein (possibly TetR-family); Rv0681, (MTV040.09), len: 196 aa. Probable transcription regulator, TetR family, similar to others and especially many tetracyc [...]
rpsL protein networkhttps://string-db.org/network/83332.Rv068230S ribosomal protein S12 RpsL; With S4 and S5 plays an important role in translational accuracy.
rpsG protein networkhttps://string-db.org/network/83332.Rv068330S ribosomal protein S7 RpsG; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit [...]
fusA1 protein networkhttps://string-db.org/network/83332.Rv0684Probable elongation factor G FusA1 (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocatio [...]
tuf protein networkhttps://string-db.org/network/83332.Rv0685Probable iron-regulated elongation factor TU Tuf (EF-TU); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
Rv0686 protein networkhttps://string-db.org/network/83332.Rv0686Probable membrane protein; Rv0686, (MTCY210.03), len: 265 aa. Probable membrane protein, with hydrophobic N-terminus.
Rv0687 protein networkhttps://string-db.org/network/83332.Rv0687Rv0687, (MTCY210.04), len: 275 aa. Probable short-chain dehydrogenase/reductase, highly similar to various dehydrogenases (generally SDR family) e.g. U17129|RSU17129_7 short-chain dehydrogenase f [...]
Rv0688 protein networkhttps://string-db.org/network/83332.Rv0688Rv0688, (MTCY210.05), len: 406 aa. Putative ferredoxin reductase, highly similar to others e.g. BAB55881.1|AB054975 ferredoxin reductase from Terrabacter sp. DBF63 (410 aa); CAC04223.1|AL391515 p [...]
Rv0689c protein networkhttps://string-db.org/network/83332.Rv0689cHypothetical protein; Rv0689c, (MTCY210.06c), len: 84 aa. Hypothetical unknown protein.
Rv0690c protein networkhttps://string-db.org/network/83332.Rv0690cRv0690c, (MTCY210.07c), len: 349 aa. Conserved hypothetical protein, showing similarity with NP_386956.1|NC_003047 conserved hypothetical protein from Sinorhizobium meliloti (358 aa); NP_356573.1 [...]
mftA protein networkhttps://string-db.org/network/83332.Rv0691AMycofactocin precursor protein; A putative polypeptide that may function as an electron carrier; the C-terminal 8 residues are highly conserved. The genes for mycofactocin and other proteins prop [...]
mftR protein networkhttps://string-db.org/network/83332.Rv0691cProbable transcriptional regulatory protein; May regulate a gene cluster involved in mycofactocin expression. Mycofactocin is a conserved polypeptide that might serve as an electron carrier.
mftB protein networkhttps://string-db.org/network/83332.Rv0692Conserved hypothetical protein; May function to bind or modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins propose [...]
pqqE protein networkhttps://string-db.org/network/83332.Rv0693Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III); May function to modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The gene [...]
lldD1 protein networkhttps://string-db.org/network/83332.Rv0694Possible L-lactate dehydrogenase (cytochrome) LldD1; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin [...]
mftE protein networkhttps://string-db.org/network/83332.Rv0695Conserved hypothetical protein; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins p [...]
mftF protein networkhttps://string-db.org/network/83332.Rv0696Probable membrane sugar transferase; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other prote [...]
Rv0697 protein networkhttps://string-db.org/network/83332.Rv0697Probable dehydrogenase; Rv0697, (MTCY210.14, unknown), len: 479 aa. Probable dehydrogenase, highly similar to P30772|YTUR_MYCLE hypothetical 24 kDa protein from Mycobacterium leprae (220 aa), FAS [...]
Rv0698 protein networkhttps://string-db.org/network/83332.Rv0698Rv0698, (MTCY210.15), len: 203 aa. Conserved hypothetical protein, highly similar to C-terminus of Rv3639c|MTY15C10.12 conserved hypothetical protein from Mycobacterium tuberculosis (188 aa), FAS [...]
Rv0699 protein networkhttps://string-db.org/network/83332.Rv0699Hypothetical protein; Rv0699, (MTCY210.17), len: 73 aa. Hypothetical unknown protein.
rpsJ protein networkhttps://string-db.org/network/83332.Rv070030S ribosomal protein S10 RpsJ (transcription antitermination factor NusE); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
rplC protein networkhttps://string-db.org/network/83332.Rv070150S ribosomal protein L3 RplC; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universa [...]
rplD protein networkhttps://string-db.org/network/83332.Rv070250S ribosomal protein L4 RplD; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It [...]
rplW protein networkhttps://string-db.org/network/83332.Rv070350S ribosomal protein L23 RplW; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main [...]
rplB protein networkhttps://string-db.org/network/83332.Rv070450S ribosomal protein L2 RplB; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation [...]
rpsS protein networkhttps://string-db.org/network/83332.Rv070530S ribosomal protein S19 RpsS; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
rplV protein networkhttps://string-db.org/network/83332.Rv070650S ribosomal protein L22 RplV; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages [...]
rpsC protein networkhttps://string-db.org/network/83332.Rv070730S ribosomal protein S3 RpsC; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.
rplP protein networkhttps://string-db.org/network/83332.Rv070850S ribosomal protein L16 RplP; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
rpmC protein networkhttps://string-db.org/network/83332.Rv0709Rv0709, (MTCY210.28), len: 77 aa. rpmC, 50S ribosomal protein L29, equivalent to O06050|RL29_MYCBO|MBS10OPER_10 50S ribosomal protein L29 from Mycobacterium bovis BCG (75 aa); and O32989|RL29_MYC [...]
rpsQ protein networkhttps://string-db.org/network/83332.Rv071030S ribosomal protein S17 RpsQ; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
atsA protein networkhttps://string-db.org/network/83332.Rv0711Rv0711, (MTCY210.30), len: 787 aa. Possible atsA,arylsulfatase, similar to others e.g. P51691|ARS_PSEAE arylsulfatase from Pseudomonas aeruginosa (532 aa), FASTA scores: opt: 439, E(): 2.9e-21, ( [...]
Rv0712 protein networkhttps://string-db.org/network/83332.Rv0712Conserved protein; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the matura [...]
Rv0713 protein networkhttps://string-db.org/network/83332.Rv0713Rv0713, (MTCY210.32), len: 313 aa. Probable conserved transmembrane protein, similar to Rv3435c|MTCY77_7|O06252 from Mycobacterium tuberculosis (284 aa), FASTA scores: opt: 557, E(): 2.1e-29, (35 [...]
rplN protein networkhttps://string-db.org/network/83332.Rv071450S ribosomal protein L14 RplN; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.
rplX protein networkhttps://string-db.org/network/83332.Rv071550S ribosomal protein L24 RplX; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
rplE protein networkhttps://string-db.org/network/83332.Rv071650S ribosomal protein L5 RplE; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protube [...]
rpsN1 protein networkhttps://string-db.org/network/83332.Rv071730S ribosomal protein S14 RpsN1; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
rpsH protein networkhttps://string-db.org/network/83332.Rv071830S ribosomal protein S8 RpsH; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belong [...]
rplF protein networkhttps://string-db.org/network/83332.Rv071950S ribosomal protein L6 RplF; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near [...]
rplR protein networkhttps://string-db.org/network/83332.Rv072050S ribosomal protein L18 RplR; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central prot [...]
rpsE protein networkhttps://string-db.org/network/83332.Rv072130S ribosomal protein S5 RpsE; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
rpmD protein networkhttps://string-db.org/network/83332.Rv0722Rv0722, (MTCY210.41), len: 65 aa. rpmD, 50S ribosomal protein L30, equivalent to O33001 ribosomal protein L30 from Mycobacterium leprae (71 aa). Also highly similar to others e.g. P46789|RL30_STR [...]
rplO protein networkhttps://string-db.org/network/83332.Rv072350S ribosomal protein L15 RplO; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
sppA protein networkhttps://string-db.org/network/83332.Rv0724Rv0724, (MTCY210.43), len: 623 aa. Possible sppA,protease IV (endopeptidase IV), equivalent (but longer 23 aa) to MLCB2492_24|O33003 endopeptidase IV from Mycobacterium leprae (602 aa). Also simi [...]
Rv0724A protein networkhttps://string-db.org/network/83332.Rv0724AConserved hypothetical protein; Rv0724A, len: 111 aa. Similarity suggests that this CDS should be continuation of Rv0725c but we can find no frame-shift to account for this. Possible extended pro [...]
Rv0725c protein networkhttps://string-db.org/network/83332.Rv0725cConserved hypothetical protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv0726c protein networkhttps://string-db.org/network/83332.Rv0726cPossible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
fucA protein networkhttps://string-db.org/network/83332.Rv0727cRv0727c, (MTV41.01c, MTCY210.46c), len: 218 aa. Possible fucA, L-fuculose-1-phosphate aldolase, similar to many e.g. NP_386339.1|NC_003047 putative L-fuculose phosphate aldolase protein from Sino [...]
serA2 protein networkhttps://string-db.org/network/83332.Rv0728cRv0728c, (MTV041.02c), len: 326 aa. Possible serA2,D-3-phosphoglycerate dehydrogenase, similar to others e.g. AF0278|AF027868_5|YoaD D-3-phosphoglycerate dehydrogenase from Bacillus subtilis (344 [...]
xylB protein networkhttps://string-db.org/network/83332.Rv0729Rv0729, (MTV041.03), len: 448 aa. Possible xylB,D-xylulose-kinase (xylulokinase). C-terminus highly similar to AAD09880.1|U77912 unknown protein from Mycobacterium bovis (102 aa); and N-terminus [...]
Rv0730 protein networkhttps://string-db.org/network/83332.Rv0730GCN5-related N-acetyltransferase; Rv0730, (MTV041.04), len: 242 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005 [...]
Rv0731c protein networkhttps://string-db.org/network/83332.Rv0731cPossible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
secY protein networkhttps://string-db.org/network/83332.Rv0732Probable preprotein translocase SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at [...]
adk protein networkhttps://string-db.org/network/83332.Rv0733Adenylate kinase Adk (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis an [...]
mapA protein networkhttps://string-db.org/network/83332.Rv0734Methionine aminopeptidase MapA (map) (peptidase M) (MetAP); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the prim [...]
sigL protein networkhttps://string-db.org/network/83332.Rv0735Probable alternative RNA polymerase sigma factor SigL; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extra [...]
rslA protein networkhttps://string-db.org/network/83332.Rv0736Anti-sigma factor RslA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigL. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regula [...]
Rv0737 protein networkhttps://string-db.org/network/83332.Rv0737Rv0737, (MTV041.11), len: 165 aa. Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 tr [...]
Rv0738 protein networkhttps://string-db.org/network/83332.Rv0738Conserved protein; Rv0738, (MTV041.12), len: 182 aa. Conserved protein,showing weak similarity with hypothetical proteins from Mycobacterium tuberculosis: Rv1727|MTCY04C12.12 (189 aa); MTY13D12_7 [...]
Rv0739 protein networkhttps://string-db.org/network/83332.Rv0739Rv0739, (MTV041.13), len: 268 aa. Conserved hypothetical protein, showing some similarity to Mycobacterium tuberculosis proteins Rv0026 (448 aa), FASTA score: (37.6% identity in 101 aa overlap)an [...]
Rv0740 protein networkhttps://string-db.org/network/83332.Rv0740Rv0740, (MTV041.14), len: 175 aa. Conserved hypothetical protein; C-terminus (possibly part of truncated IS1557) shows nearly perfect identity to Rv0750|MTV041_24 (81 aa), FASTA score: (92.6% ide [...]
Rv0741 protein networkhttps://string-db.org/network/83332.Rv0741Probable transposase (fragment); Rv0741, (MTV041.15), len: 104 aa. Probable truncated transposase for IS1557, showing similarity to transposases and is elements e.g. U63997|EFU63997_1 insertion s [...]
PE_PGRS8 protein networkhttps://string-db.org/network/83332.Rv0742PE-PGRS family protein PE_PGRS8; Rv0742, (MTV041.16), len: 175 aa. PE_PGRS8, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar [...]
Rv0743c protein networkhttps://string-db.org/network/83332.Rv0743cHypothetical protein; Rv0743c, (MTV041.17c), len: 185 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv0744c protein networkhttps://string-db.org/network/83332.Rv0744cRv0744c, (MTV041.18c), len: 168 aa. Possible transcriptional regulator, showing weak similarity with O86661|SC4A2.05 putative two-component sensor from Streptomyces coelicolor (436 aa), FASTA sco [...]
Rv0745 protein networkhttps://string-db.org/network/83332.Rv0745Rv0745, (MTV041.19), len: 175 aa. Conserved hypothetical protein; shows high similarity to a 50 aa region of Rv3649|Z95436|MTY15C10_3 conserved hypothetical protein, similar to ATP-dependent heli [...]
PE_PGRS9 protein networkhttps://string-db.org/network/83332.Rv0746PE-PGRS family protein PE_PGRS9; Rv0746, (MTV041.20), len: 783 aa. PE_PGRS9, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly s [...]
PE_PGRS10 protein networkhttps://string-db.org/network/83332.Rv0747PE-PGRS family protein PE_PGRS10; Rv0747, (MTV041.21), len: 801 aa. PE_PGRS10, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly [...]
vapB31 protein networkhttps://string-db.org/network/83332.Rv0748Possible antitoxin VapB31; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC31.
vapC31 protein networkhttps://string-db.org/network/83332.Rv0749Possible toxin VapC31. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv0749A protein networkhttps://string-db.org/network/83332.Rv0749ARv0749A, len: 45 aa. Conserved hypothetical protein (probably gene fragment), similar to part (aa 250-292) of Rv2807|Z81331_12 from Mycobacterium tuberculosis (384 aa),FASTA scores: opt: 238, E() [...]
Rv0750 protein networkhttps://string-db.org/network/83332.Rv0750Rv0750, (MTV041.24), len: 81 aa. Conserved hypothetical protein, showing almost perfect overlap with C-terminus of Rv0740|MTV041_14 conserved hypothetical protein from Mycobacterium tuberculosis [...]
mmsB protein networkhttps://string-db.org/network/83332.Rv0751cRv0751c, (MTV041.25c), len: 294 aa. Probable mmsB,3-hydroxyisobutyrate dehydrogenase, highly similar to others e.g. NP_102847.1|NC_002678 3-hydroxyisobutyrate dehydrogenase from Mesorhizobium lot [...]
fadE9 protein networkhttps://string-db.org/network/83332.Rv0752cRv0752c, (MTV041.26c), len: 390 aa. Probable fadE9,acyl-CoA dehydrogenase, highly similar to many e.g. NP_437985.1|NC_003078 putative acyl-CoA dehydrogenase protein from Sinorhizobium meliloti (3 [...]
mmsA protein networkhttps://string-db.org/network/83332.Rv0753cRv0753c, (MTV041.27c), len: 510 aa. Probable mmsA,methylmalonic acid semialdehyde dehydrogenase, highly similar to others e.g. NP_420115.1|NC_002696 putative methylmalonate-semialdehyde dehydroge [...]
PE_PGRS11 protein networkhttps://string-db.org/network/83332.Rv0754PE-PGRS family protein PE_PGRS11; Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa- B signaling pathways, and enha [...]
Rv0755A protein networkhttps://string-db.org/network/83332.Rv0755ARv0755A, len: 61 aa. Putative transposase (possibly gene fragment), similar to C-terminal part of Q9EZM2|ISMav2|AF286339_1 putative transposase from Mycobacterium paratuberculosis (395 aa), FASTA [...]
PPE12 protein networkhttps://string-db.org/network/83332.Rv0755cRv0755c, (MTV041.29), len: 645 aa. PPE12, Member of the Mycobacterium tuberculosis PPE family, highly similar to others e.g. Z82098|MTCY3C7_23 from Mycobacterium tuberculosis (582 aa), FASTA scor [...]
Rv0756c protein networkhttps://string-db.org/network/83332.Rv0756cUnknown protein; Rv0756c, (MTCY369.01c), len: 241 aa. Unknown protein.
phoP protein networkhttps://string-db.org/network/83332.Rv0757Rv0757, (MTCY369.02), len: 247 aa. Possible phoP,two component system response phosphate regulon transcriptional regulator (see citations below), highly similar to various transcriptional regulat [...]
phoR protein networkhttps://string-db.org/network/83332.Rv0758Rv0758, (MTCY369.03), len: 485 aa. Possible phoR,two component system response phosphate sensor kinase membrane-associated, highly similar to various sensor kinases e.g. CAC32361.1|AL583945 putat [...]
Rv0759c protein networkhttps://string-db.org/network/83332.Rv0759cRv0759c, (MTCY369.04c), len: 110 aa. Conserved hypothetical protein, highly similar (but shorter 45 aa in N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A hypothetical hit-like protein fro [...]
Rv0760c protein networkhttps://string-db.org/network/83332.Rv0760cConserved protein; Rv0760c, (MTCY369.05), len: 139 aa. Conserved protein, similar to N-terminal part of Rv2042c conserved hypothetical protein from Mycobacterium tuberculosis (265 aa), FASTA scor [...]
adhB protein networkhttps://string-db.org/network/83332.Rv0761cRv0761c, (MTCY369.06c), len: 375 aa. Possible adhB,zinc-containing alcohol dehydrogenase NAD-dependent,similar to others e.g. AAC15839.1|AF060871_4 hypothetical alcohol dehydrogenase from Rhodoco [...]
Rv0762c protein networkhttps://string-db.org/network/83332.Rv0762cRv0762c, (MTCY369.07c), len: 181 aa. Conserved hypothetical protein, showing weak similarity to D90907_77|P73575 hypothetical 31.3KD protein from Synechocystis sp, FASTA scores: E(): 0.0012, (30. [...]
Rv0763c protein networkhttps://string-db.org/network/83332.Rv0763cPossible ferredoxin; Rv0763c, (MTCY369.08c), len: 68 aa. Possible ferredoxin, similar to others and related proteins e.g. P18324|FER1_STRGO|SUAB ferredoxin 1 (fd-1) from Streptomyces griseolus (6 [...]
cyp51 protein networkhttps://string-db.org/network/83332.Rv0764cLanosterol 14-alpha demethylase; Its precise biological substrate is not known. Catalyzes C14- demethylation of lanosterol, 24,25-dihydrolanosterol and obtusifoliol which is critical for ergoster [...]
Rv0765c protein networkhttps://string-db.org/network/83332.Rv0765cRv0765c, (MTCY369.10c), len: 275 aa. Probable oxidoreductase, similar others e.g. P39071|DHBA_BACSU 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase from Bacillus subtilis (261 aa), FASTA scores: [...]
cyp123 protein networkhttps://string-db.org/network/83332.Rv0766cRv0766c, (MT0790, MTCY369.11c), len: 402 aa. Probable cyp123, cytochrome P-450, similar to others e.g. P33271|CPXK_SACER cytochrome P-450 107B1 from Saccharopolyspora erythraea (405 aa), FASTA sc [...]
Rv0767c protein networkhttps://string-db.org/network/83332.Rv0767cRv0767c, (MTCY369.12c), len: 213 aa. Conserved hypothetical protein, showing weak similarity with AL133220|SCC75A_26 hypothetical protein from Streptomyces coelicolor (215 aa), FASTA scores: opt: [...]
aldA protein networkhttps://string-db.org/network/83332.Rv0768Rv0768, (MTCY369.13), len: 489 aa. Probable aldA,NAD-dependent aldehyde dehydrogenase, highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 [...]
Rv0769 protein networkhttps://string-db.org/network/83332.Rv0769Rv0769, (MTCY369.14), len: 248 aa. Probable dehydrogenase/reductase, similar to others, especially short-chain type dehydrogenases/reductases and 3-oxoacyl-(acyl-carrier protein) reductases e.g. [...]
Rv0770 protein networkhttps://string-db.org/network/83332.Rv0770Rv0770, (MTCY369.15), len: 295 aa. Probable dehydrogenase/reductase, 3-hydroxyisobutyrate dehydrogenase family, possibly 3-hydroxyisobutyrate dehydrogenase or 2-hydroxy-3-oxopropionate reductase, [...]
Rv0771 protein networkhttps://string-db.org/network/83332.Rv0771Rv0771, (MTCY369.16), len: 144 aa. Possible 4-carboxymuconolactone decarboxylase, showing similarity with other carboxymuconolactone decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein from [...]
purD protein networkhttps://string-db.org/network/83332.Rv0772Phosphoribosylamine--glycine ligase; Rv0772, (MTCY369.17), len: 422 aa. Probable purD,phosphoribosylamine--glycine ligase, equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08 phosphoribosylamine [...]
ggtA protein networkhttps://string-db.org/network/83332.Rv0773cGamma-glutamyltranspeptidase / glutathione hydrolase; Rv0773c, (MTCY369.18), len: 512 aa. Probable ggtA,bifunctional acylase including cephalosporin acylase, and gamma-glutamyl transpeptidase; hi [...]
Rv0774c protein networkhttps://string-db.org/network/83332.Rv0774cRv0774c, (MTCY369.19c), len: 303 aa. Possible conserved exported protein with hydrophobic region near N-terminus, highly similar, except in N-terminus, to Rv0519c|Z97831|MTY20G10.09c|O33364 hypot [...]
Rv0775 protein networkhttps://string-db.org/network/83332.Rv0775Rv0775, (MTCY369.20), len: 207 aa. Conserved hypothetical protein, showing some similarity to other proteins e.g. ECAE000186_11|MG1655 hypothetical protein from Escherichia coli strain K-12 (178 [...]
Rv0776c protein networkhttps://string-db.org/network/83332.Rv0776cRv0776c, (MTCY369.21a), len: 259 aa. Conserved hypothetical protein, similar (except first 50 aa) to P72737|D90900_57 hypothetical protein from Synechocystis sp. strain PCC 6803 (261 aa), FASTA s [...]
purB protein networkhttps://string-db.org/network/83332.Rv0777Rv0777, (MTCY369.21b), len: 472 aa. Probable purB,adenylosuccinate lyase, equivalent (but shorter 15 aa) to MLCB5.13|Z95151|g2076607|PURB adenylosuccinate lyase from Mycobacterium leprae (487 aa) [...]
cyp126 protein networkhttps://string-db.org/network/83332.Rv0778Rv0778, (MT0802, MTCY369.22), len: 414 aa. Possible cyp126, cytochrome P-450, similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomy [...]
Rv0779c protein networkhttps://string-db.org/network/83332.Rv0779cRv0779c, (MTCY369.23c), len: 206 aa. Possible conserved transmembrane protein, equivalent to Z95151|MLCB5_14 O05747 conserved hypothetical protein from Mycobacterium leprae (206 aa), FASTA scores [...]
purC protein networkhttps://string-db.org/network/83332.Rv0780Phosphoribosylaminoimidazole-succinocarboxamide synthase PurC (SAICAR synthetase); Rv0780, (MTCY369.24), len: 297 aa. PurC,phosphoribosylaminoimidazole- succinocarboxamide synthase (see citations [...]
ptrBa protein networkhttps://string-db.org/network/83332.Rv0781Rv0781, (MTCY369.25), len: 236 aa. Probable ptrBa,first part of protease II, equivalent to N-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar [...]
ptrBb protein networkhttps://string-db.org/network/83332.Rv0782Rv0782, (MTCY369.26), len: 552 aa. Probable ptrBb,second part of protease II, equivalent to C-terminus of NP_302455.1|NC_002677 protease II from Mycobacterium leprae (724 aa). Also highly similar [...]
emrB protein networkhttps://string-db.org/network/83332.Rv0783cRv0783c, (MTCY369.27c), len: 540 aa. Possible emrB,integral membrane drug efflux protein, member of major facilitator superfamily (MFS), equivalent to AAL16083.1|AF421382_1|AF421382 EmrB efflux p [...]
Rv0784 protein networkhttps://string-db.org/network/83332.Rv0784Rv0784, (MTC369.28), len: 228 aa. Conserved hypothetical protein, with some similarity to MLCB5_20|O05752 hypothetical protein from Mycobacterium leprae (193 aa), FASTA scores: opt: 141, E(): 0.0 [...]
Rv0785 protein networkhttps://string-db.org/network/83332.Rv0785Conserved protein; Able to catalyze the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3- ketosteroids.
Rv0786c protein networkhttps://string-db.org/network/83332.Rv0786cConserved protein; Rv0786c, (MTCY369.30c), len: 129 aa. Conserved protein, similar to three other hypothetical proteins from Streptomyces coelicolor e.g. SC7H1.08c|T35703 hypothetical protein (20 [...]
Rv0787 protein networkhttps://string-db.org/network/83332.Rv0787Unknown protein; Rv0787, (MTCY369.31), len: 319 aa. Unknown protein,equivalent to AAK45053.1 from Mycobacterium tuberculosis strain CDC1551 (242 aa) but longer 77 aa.
purS protein networkhttps://string-db.org/network/83332.Rv0787AConserved protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonuc [...]
purQ protein networkhttps://string-db.org/network/83332.Rv0788Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyze [...]
Rv0789c protein networkhttps://string-db.org/network/83332.Rv0789cHypothetical protein; Rv0789c, (MTCY369.33c), len: 199 aa. Hypothetical unknown protein.
Rv0790c protein networkhttps://string-db.org/network/83332.Rv0790cHypothetical protein; Rv0790c, (MTCY369.34c), len: 242 aa. Hypothetical unknown protein.
Rv0791c protein networkhttps://string-db.org/network/83332.Rv0791cConserved protein; Rv0791c, (MTV042.01c, MTCY369.35c), len: 347 aa. Conserved protein, similar (except in N-terminus) to others e.g. CAC44585.1|AL596162 conserved hypothetical protein from Strept [...]
Rv0792c protein networkhttps://string-db.org/network/83332.Rv0792cProbable transcriptional regulatory protein (probably GntR-family); Rv0792c, (MTV042.02c), len: 269 aa. Probable transcriptional regulator, GntR-family, similar to many others of GntR family e.g. [...]
Rv0793 protein networkhttps://string-db.org/network/83332.Rv0793Possible monooxygenase; Putative monooygenase that might be involved in antibiotic biosynthesis, or may act as reactive oxygen species scavenger that could help in evading host defenses.
Rv0794c protein networkhttps://string-db.org/network/83332.Rv0794cRv0794c, (MTV042.04c), len: 499 aa. Probable oxidoreductase, possibly dihydrolipoamide dehydrogenase or mercuric reductase. Highly similar to CAB62675.1|AL133422 probable oxidoreductase from Stre [...]
Rv0795 protein networkhttps://string-db.org/network/83332.Rv0795Rv0795, (MTV042.05), len: 108 aa. Putative transposase for IS6110 (fragment), identical to Q50686 insertion element IS6110 (108 aa), FASTA score: (100.0 % identity in 108 aa overlap). The transpo [...]
Rv0796 protein networkhttps://string-db.org/network/83332.Rv0796Putative transposase for insertion sequence element IS6110; Involved in the transposition of the insertion sequence.
Rv0797 protein networkhttps://string-db.org/network/83332.Rv0797Rv0797, (MTCI249B.03c, MTV042.07), len: 364 aa. Putative transposase for IS1547; almost identical to (but 20 aa shorter than) Y13470|MTY13470_2 from Mycobacterium tuberculosis (383 aa). Also simi [...]
cfp29 protein networkhttps://string-db.org/network/83332.Rv0798c29 KDa antigen CFP29; Rv0798c, (MTCI429B.02), len: 265 aa. Cfp29, 29 kDa antigen (see citations below). Highly similar to Q45296|BLLINM18P_1|CAA63787.1|X93588 linocin M18 from Brevibacterium line [...]
Rv0799c protein networkhttps://string-db.org/network/83332.Rv0799cConserved protein; Rv0799c, (MTCY07H7A.10, MTCI429B.01), len: 335 aa. Conserved protein, similar to Q50021|U2266C from Mycobacterium leprae (146 aa), FASTA scores: opt: 147, E(): 0.0016, (33.3% i [...]
pepC protein networkhttps://string-db.org/network/83332.Rv0800Rv0800, (MTCY07H7A.09c), len: 433 aa. Probable pepC,aminopeptidase I, highly similar (but shorter 17 aa) to Q50022|PEPX aminopeptidase from Mycobacterium leprae (443 aa), FASTA scores: opt: 2237, [...]
Rv0801 protein networkhttps://string-db.org/network/83332.Rv0801Conserved protein; Rv0801, (MTCY07H7A.08c), len: 115 aa. Conserved protein, similar to many hypothetical proteins from Streptomyces sp. e.g. SCD840A.20|AB81865.1|AL161691 hypothetical protein fro [...]
Rv0802c protein networkhttps://string-db.org/network/83332.Rv0802cPossible succinyltransferase in the GCN5-related N-acetyltransferase family; May function as a succinyl-CoA transferase.
purL protein networkhttps://string-db.org/network/83332.Rv0803Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the A [...]
Rv0804 protein networkhttps://string-db.org/network/83332.Rv0804Rv0804, (MTCY07H7A.05c), len: 209 aa. Conserved hypothetical protein, showing similarity with C-terminus of Rv1863c|MTCY359.10 conserved hypothetical protein from Mycobacterium tuberculosis (256 [...]
cpdA protein networkhttps://string-db.org/network/83332.Rv0805Class III cyclic nucleotide phosphodiesterase (cNMP PDE); Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing [...]
cpsY protein networkhttps://string-db.org/network/83332.Rv0806cExopolysaccharide phosphotransferase CpsY; Rv0806c, (MTCY07H7A.03), len: 532 aa. Possible cpsY,UDP-glucose-4-epimerase, equivalent to Q50025|CPSY probable UDP-glucose-4-epimerase from Mycobacteri [...]
Rv0807 protein networkhttps://string-db.org/network/83332.Rv0807Rv0807, (MTCY07H7A.02c), len: 129 aa. Conserved hypothetical protein, equivalent to O05761|MLCB5_31 hypothetical 14.0 kDa protein from Mycobacterium leprae (131 aa), FASTA scores: E(): 0, (73.4% [...]
purF protein networkhttps://string-db.org/network/83332.Rv0808Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
purM protein networkhttps://string-db.org/network/83332.Rv0809Phosphoribosylformylglycinamidine cyclo-ligase; Rv0809, (MTV043.01), len: 364 aa. Probable purM,5'-phosphoribosyl-5-aminoimidazole synthetase, equivalent to NP_302446.1|NC_002677 5'-phosphoribosy [...]
Rv0810c protein networkhttps://string-db.org/network/83332.Rv0810cRv0810c, (MTV043.02c), len: 60 aa. Conserved hypothetical protein, with its N-terminus highly similar to NP_302445.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (62 aa); an [...]
Rv0811c protein networkhttps://string-db.org/network/83332.Rv0811cConserved protein; Rv0811c, (MTV043.03c), len: 368 aa. Conserved protein, equivalent to U2266F|U15182|MLU15182_13 hypothetical protein from Mycobacterium leprae (366 aa),FASTA scores: opt: 1870, [...]
Rv0812 protein networkhttps://string-db.org/network/83332.Rv0812Rv0812, (MTV043.04), len: 289 aa. Probable amino acid aminotransferase, similar to other amino acid aminotransferases, generelly class-IV of pyridoxal-phosphate-dependent aminotransferases, and e [...]
Rv0813c protein networkhttps://string-db.org/network/83332.Rv0813cConserved protein; May play a role in the intracellular transport of hydrophobic ligands; Belongs to the UPF0678 family.
sseC2 protein networkhttps://string-db.org/network/83332.Rv0814cConserved protein SseC2; Rv0814c, (MTV043.06c, O05794), len: 100 aa. SseC2,conserved protein, highly similar to AAA62972.1|U15182|MLU15182_17 hypothetical protein from Mycobacterium leprae (143 a [...]
cysA2 protein networkhttps://string-db.org/network/83332.Rv0815cPutative thiosulfate sulfurtransferase; May be a sulfotransferase involved in the formation of thiosulfate.
thiX protein networkhttps://string-db.org/network/83332.Rv0816cRv0816c, (MTV043.08c), len: 140 aa. Probable thiX,thioredoxin, equivalent to ThiX|U15182|MLU15182_21 thioredoxin from Mycobacterium leprae (172 aa), FASTA scores: opt: 556, E(): 8.8e-31, (63.8% i [...]
Rv0817c protein networkhttps://string-db.org/network/83332.Rv0817cRv0817c, (MTV043.09c), len: 270 aa. Probable conserved exported protein, with N-terminal signal sequence, equivalent (but shorter 13 aa) to U15182|MLU15182_22|U2266M probable exported protein fro [...]
Rv0818 protein networkhttps://string-db.org/network/83332.Rv0818Transcriptional regulatory protein; Rv0818, (MTV043.10), len: 255 aa. Probable transcriptional regulatory protein, highly similar to Q05943|GLNR_STRCO|L03213|STMGLNR_1|SCD84.26c transcriptional r [...]
mshD protein networkhttps://string-db.org/network/83332.Rv0819GCN5-related N-acetyltransferase, MshD; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subf [...]
phoT protein networkhttps://string-db.org/network/83332.Rv0820Probable phosphate-transport ATP-binding protein ABC transporter PhoT; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the [...]
phoY2 protein networkhttps://string-db.org/network/83332.Rv0821cProbable phosphate-transport system transcriptional regulatory protein PhoY2; Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone, to PhoR, PhoP [...]
Rv0822c protein networkhttps://string-db.org/network/83332.Rv0822cConserved protein; Rv0822c, (MTV043.14c), len: 684 aa. Conserved protein, highly similar in the region between aa 370 - 580 to U2266O|U15182|MLU15182_30 hypothetical protein from Mycobacterium le [...]
dus protein networkhttps://string-db.org/network/83332.Rv0823cPossible transcriptional regulatory protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in ta [...]
desA1 protein networkhttps://string-db.org/network/83332.Rv0824cPutative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis.
Rv0825c protein networkhttps://string-db.org/network/83332.Rv0825cConserved protein; Rv0825c, (MTV043.17c), len: 213 aa. Conserved protein, highly similar, but in part (between aa ~43-96) to fadD27|Rv0275c|MTV035.03 putative fatty-acid-CoA ligase from Mycobacte [...]
Rv0826 protein networkhttps://string-db.org/network/83332.Rv0826Rv0826, (MTV043.18), len: 351 aa. Conserved hypothetical protein, similar to CAB94053.1|AL358672|SC7A12.06 hypothetical protein from Streptomyces coelicolor (300 aa); and NP_421372.1|NC_002696 hy [...]
kmtR protein networkhttps://string-db.org/network/83332.Rv0827cMetal sensor transcriptional regulator KmtR (ArsR-SmtB family); Represses expression of Rv2025c and its own expression. Acts by binding to the promoter regions.
Rv0828c protein networkhttps://string-db.org/network/83332.Rv0828cPossible deaminase; Rv0828c, (MTV043.20c), len: 140 aa. Possible deaminase, with its N-terminus highly similar to middle part of NP_302602.1|NC_002677 possible cytidine/deoxycytidylate deaminase [...]
Rv0829 protein networkhttps://string-db.org/network/83332.Rv0829Rv0829, (MTV043.21), len: 96 aa. Possible transposase for IS1605' (fragment), similar to C-terminal end of many mycobacterial transposases and hypothetical proteins e.g. Z74024|MTCY274_16 from My [...]
Rv0830 protein networkhttps://string-db.org/network/83332.Rv0830Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv0831c protein networkhttps://string-db.org/network/83332.Rv0831cConserved protein; Rv0831c, (MTV043.23c), len: 271 aa. Conserved protein, similar to Rv0347|MTY13E10_7|Z95324 conserved hypothetical protein from Mycobacterium tuberculosis (328 aa), FASTA scores [...]
PE_PGRS12 protein networkhttps://string-db.org/network/83332.Rv0832PE-PGRS family protein PE_PGRS12; Rv0832, (MTV043.24), len: 137 aa. PE_PGRS12, Member of the Mycobacterium tuberculosis PE family, possibly PGRS subfamily of gly-rich proteins (see citation below [...]
PE_PGRS13 protein networkhttps://string-db.org/network/83332.Rv0833PE-PGRS family protein PE_PGRS13; Rv0833, (MTV043.25), len: 749 aa. PE_PGRS13, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 200 [...]
PE_PGRS14 protein networkhttps://string-db.org/network/83332.Rv0834cPE-PGRS family protein PE_PGRS14; Rv0834c, (MTV043.26c), len: 882 aa. PE_PGRS14,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
lpqQ protein networkhttps://string-db.org/network/83332.Rv0835Rv0835, (MTV043.27), len: 214 aa. Possible lpqQ,lipoprotein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
Rv0836c protein networkhttps://string-db.org/network/83332.Rv0836cHypothetical protein; Rv0836c, (MTV043.29c), len: 217 aa (start uncertain). Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv0837c protein networkhttps://string-db.org/network/83332.Rv0837cHypothetical protein; Rv0837c, (MTV043.30c), len: 342 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
lpqR protein networkhttps://string-db.org/network/83332.Rv0838Probable conserved lipoprotein LpqR; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
Rv0839 protein networkhttps://string-db.org/network/83332.Rv0839Rv0839, (MTV043.32), len: 270 aa. Conserved hypothetical protein, similar to various hypothetical proteins or methyltransferases from yeast and bacteria e.g. T34740|SC1E6.19c|AL033505|SC1E6_19 hy [...]
pip protein networkhttps://string-db.org/network/83332.Rv0840cProbable proline iminopeptidase Pip (prolyl aminopeptidase) (pap); Rv0840c, (MTV043.33c), len: 286 aa. Possible pip,proline iminopeptidase, similar to many e.g. P46541|PIP_BACCO proline iminopept [...]
Rv0841 protein networkhttps://string-db.org/network/83332.Rv0841Rv0841, len: 80 aa. Conserved transmembrane protein,highly similar to C-terminus of next ORF Rv0842|O53854 putative membrane protein from Mycobacterium tuberculosis (442 aa), FASTA scores: opt: 2 [...]
Rv0842 protein networkhttps://string-db.org/network/83332.Rv0842Rv0842, (MT0864, MTV043.35), len: 430 aa. Probable conserved integral membrane protein, showing similarity with other integral membrane proteins e.g. P28246|BCR_ECOLI bicyclomycin resistance prot [...]
Rv0843 protein networkhttps://string-db.org/network/83332.Rv0843Rv0843, (MTV043.36), len: 334 aa. Probable dehydrogenase, similar to various dehydrogenases e.g. Q46142|Q46142 TPP-dependent acetoin dehydrogenase (326 aa),FASTA scores: opt: 500, E(): 2.4e-26, ( [...]
narL protein networkhttps://string-db.org/network/83332.Rv0844cPossible nitrate/nitrite response transcriptional regulatory protein NarL; Member of the two-component regulatory system NarS/NarL that regulates genes involved in aerobic nitrate metabolism. Upo [...]
narS protein networkhttps://string-db.org/network/83332.Rv0845Possible two component sensor kinase; Member of the two-component regulatory system NarS/NarL involved in gene expression during aerobic nitrate metabolism. Plays therefore a crucial role in anae [...]
mmcO protein networkhttps://string-db.org/network/83332.Rv0846cProbable oxidase; Required for copper resistance. In vitro, oxidizes organic substrates and Fe(2+). May act in vivo by oxidation of toxic periplasmic Cu(+); Belongs to the multicopper oxidase fam [...]
lpqS protein networkhttps://string-db.org/network/83332.Rv0847Probable lipoprotein LpqS; May play an essential role in M.tuberculosis replication and survival inside the host cell.
cysK2 protein networkhttps://string-db.org/network/83332.Rv0848S-sulfocysteine synthase; Catalyzes the synthesis of S-sulfocysteine, utilizing O- phosphoserine (OPS) and thiosulfate as substrates. To a lesser extent, can also use sulfide as donor substrate, [...]
Rv0849 protein networkhttps://string-db.org/network/83332.Rv0849Rv0849, (MTV043.42), len: 419 aa. Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS) involved in transport of drug, showing similarity [...]
Rv0850 protein networkhttps://string-db.org/network/83332.Rv0850Rv0850, (MTV043.43), len: 110 aa. Putative transposase (fragment), similar in part to others e.g. Q45144|Q4514 transposable element IS31831 (436 aa), FASTA scores: opt: 175, E(): 4.3e-05, (38.6% [...]
Rv0851c protein networkhttps://string-db.org/network/83332.Rv0851cRv0851c, (MTV043.44c), len: 275 aa. Probable short-chain dehydrogenase/reductase, similar to many e.g. Q01198|LIGD_PSEPA C alpha-dehydrogenase (SDR family) from Pseudomonas paucimobilis (Sphingom [...]
fadD16 protein networkhttps://string-db.org/network/83332.Rv0852Rv0852, (MTV043.45), len: 278 aa. Possible fadD16,fatty-acid-CoA synthetase, similar in part to various CoA ligases e.g. P18163|LCFB_RAT long-chain-fatty-acid--CoA ligase from Rattus norvegicus ( [...]
pdc protein networkhttps://string-db.org/network/83332.Rv0853cProbable pyruvate or indole-3-pyruvate decarboxylase Pdc; Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes; Belongs to the TPP enzyme family.
Rv0854 protein networkhttps://string-db.org/network/83332.Rv0854Conserved protein; Rv0854, (MTV043.47), len: 147 aa. Conserved protein,similar to several hypothetical protein from Mycobacterium leprae e.g. NP_301674.1|NC_002677 (144 aa); NP_302683.1|NC_002677 [...]
far protein networkhttps://string-db.org/network/83332.Rv0855Rv0855, (MTV043.48), len: 359 aa. Probable far,fatty acid-CoA racemase, highly similar to CAB08122.1|Z94723 unknown protein from Mycobacterium leprae (253 aa) (C-terminus shorter). Also similar t [...]
Rv0856 protein networkhttps://string-db.org/network/83332.Rv0856Rv0856, (MTV043.49), len: 134 aa. Conserved hypothetical protein, showing weak similarity with NP_301674.1| (NC_002677) conserved hypothetical protein from Mycobacterium leprae (144 aa); and SC6G [...]
Rv0857 protein networkhttps://string-db.org/network/83332.Rv0857Rv0857, (MTV043.50), len: 157 aa. Conserved hypothetical protein, showing weak similarity with Q9X7Y8|SC6G10.02c|T35511 hypothetical protein from Streptomyces coelicolor (144 aa), FASTA scores: o [...]
dapC protein networkhttps://string-db.org/network/83332.Rv0858cProbable N-succinyldiaminopimelate aminotransferase DapC (DAP-at); Involved in the lysine biosynthetic pathways. It catalyzes the transfer of an amino group from L-glutamate to N-succinyl-2-l- am [...]
fadA protein networkhttps://string-db.org/network/83332.Rv0859Rv0859, (MTV043.52), len: 403 aa. Possible fadA,acyl-CoA thiolase, equivalent to NP_302423.1|NC_002677 putative beta-ketoadipyl CoA thiolase from Mycobacterium leprae (403 aa). Also highly simila [...]
fadB protein networkhttps://string-db.org/network/83332.Rv0860Rv0860, (MTV043.53), len: 720 aa. Probable fadB,fatty oxidation protein, equivalent to NP_302422.1|NC_002677 putative fatty oxidation complex alpha subunit from Mycobacterium leprae (714 aa). Als [...]
ercc3 protein networkhttps://string-db.org/network/83332.Rv0861cDNA helicase Ercc3; Rv0861c, (MTV043.54c), len: 542 aa. Ercc3, DNA helicase (see citation below), equivalent to NP_302420.1|NC_002677 probable DNA helicase from Mycobacterium leprae (549 aa). Als [...]
Rv0862c protein networkhttps://string-db.org/network/83332.Rv0862cConserved protein; Rv0862c, (MTV043.55c), len: 756 aa. Conserved protein, equivalent to NP_302419.1|NC_002677 possible DNA-binding protein from Mycobacterium leprae (753 aa); and highly similar ( [...]
Rv0863 protein networkhttps://string-db.org/network/83332.Rv0863Rv0863, (MTV043.56), len: 93 aa. Conserved hypothetical protein, highly similar to NP_302418.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (74 aa). Also weakly similar in p [...]
moaC2 protein networkhttps://string-db.org/network/83332.Rv0864Probable molybdenum cofactor biosynthesis protein C 2 MoaC2; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs [...]
mog protein networkhttps://string-db.org/network/83332.Rv0865Rv0865, (MTV043.58), len: 160 aa. Probable mog,molybdopterin biosynthesis MOG protein, highly similar or similar to other molybdenum cofactor biosynthesis proteins e.g. CAB59675.1|AL132674 molybd [...]
moaE2 protein networkhttps://string-db.org/network/83332.Rv0866Molybdopterin synthase catalytic subunit 2; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene gr [...]
rpfA protein networkhttps://string-db.org/network/83332.Rv0867cPossible resuscitation-promoting factor RpfA; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little t [...]
moaD2 protein networkhttps://string-db.org/network/83332.Rv0868cRv0868c, (MTV043.61c), len: 92 aa. Probable moaD2,molybdenum cofactor biosynthesis protein (molybdopterin converting factor (subunit 1)), similar to CAB88494.1|AL353816 putative molybdopterin con [...]
moaA2 protein networkhttps://string-db.org/network/83332.Rv0869cProbable molybdenum cofactor biosynthesis protein A2 MoaA2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
Rv0870c protein networkhttps://string-db.org/network/83332.Rv0870cRv0870c, (MTV043.63c), len: 129 aa. Possible conserved integral membrane protein, highly similar to other membrane proteins: putative secreted proteins or hypothetical proteins e.g. CAC08263.1| A [...]
cspB protein networkhttps://string-db.org/network/83332.Rv0871Rv0871, (MTV043.64), len: 135 aa. Probable cspB,cold shock-like protein B, equivalent to Z99494|MLCB57_7|MLCB57.11 probable cold shock protein from Mycobacterium leprae (136 aa), FASTA scores: op [...]
PE_PGRS15 protein networkhttps://string-db.org/network/83332.Rv0872cPE-PGRS family protein PE_PGRS15; Rv0872c, (MTV043.65c), len: 606 aa. PE_PGRS15,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
fadE10 protein networkhttps://string-db.org/network/83332.Rv0873Rv0873, (MTV043.66-MTCY31.01), len: 650 aa. Probable fadE10, acyl-CoA dehydrogenase, highly similar to many e.g. CAB91129.1|AL355913 putative acyl CoA dehydrogenase from Streptomyces coelicolor ( [...]
Rv0874c protein networkhttps://string-db.org/network/83332.Rv0874cRv0874c, (MTCY31.02c), len: 386 aa. Conserved hypothetical protein, highly similar in part to SPU62616_1 hypothetical protein from Synechococcus sp. (280 aa), FASTA scores: E(): 6.3e-26, (35.2% i [...]
Rv0875c protein networkhttps://string-db.org/network/83332.Rv0875cRv0875c, (MTCY31.03c), len: 162 aa. Possible conserved exported protein, equivalent to MLCB57_11|O33056 possible exported protein from Mycobacterium leprae (162 aa), FASTA scores: opt: 789, E(): [...]
Rv0876c protein networkhttps://string-db.org/network/83332.Rv0876cRv0876c, (MTCY31.04c), len: 548 aa. Possible conserved transmembrane protein, equivalent to MLCB57_12|O33057 possible membrane protein from Mycobacterium leprae (579 aa), FASTA scores: opt: 2850, [...]
Rv0877 protein networkhttps://string-db.org/network/83332.Rv0877Rv0877, (MTCY31.05), len: 262 aa. Conserved hypothetical protein, equivalent to MLCB57_13|O33058 conserved hypothetical protein from Mycobacterium leprae (269 aa), FASTA scores: E(): 0, (80.5% id [...]
PPE13 protein networkhttps://string-db.org/network/83332.Rv0878cRv0878c, (MTCY31.06c), len: 443 aa. PPE13, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. P4261|YHS6_MYCTU (517 aa), FASTA scores: opt: 1044, E(): 0, (47.4% iden [...]
Rv0879c protein networkhttps://string-db.org/network/83332.Rv0879cRv0879c, (MTCY31.07c), len: 91 aa. Possible conserved transmembrane protein, C-terminus highly similar to C-terminal part of MLCB57_14|O33059 conserved hypothetical protein from Mycobacterium lep [...]
Rv0880 protein networkhttps://string-db.org/network/83332.Rv0880Possible transcriptional regulatory protein (possibly MarR-family); Rv0880, (MTCY31.08), len: 143 aa. Possible transcriptional regulator, MarR family, equivalent to MLCB57_15|O3306|NP_302411.1|NC [...]
Rv0881 protein networkhttps://string-db.org/network/83332.Rv0881Rv0881, (MTCY31.09), len: 288 aa. Possible rRNA methyltransferase, highly similar to others and hypothetical proteins e.g. CAB76071.1|AL157953 putative rRNA methylase from Streptomyces coelicolor [...]
Rv0882 protein networkhttps://string-db.org/network/83332.Rv0882Rv0882, (MTCY31.10), len: 94 aa. Probable transmembrane protein.
Rv0883c protein networkhttps://string-db.org/network/83332.Rv0883cRv0883c, (MTCY31.11c), len: 253 aa. Conserved hypothetical protein, equivalent to O3306|MLCB57_16 conserved hypothetical protein from Mycobacterium leprae (251 aa), FASTA scores: E(): 0, (79.4% i [...]
serC protein networkhttps://string-db.org/network/83332.Rv0884cPossible phosphoserine aminotransferase SerC (PSAT); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohy [...]
Rv0885 protein networkhttps://string-db.org/network/83332.Rv0885Rv0885, (MTCY31.13), len: 340 aa. Conserved hypothetical protein, equivalent to O33063|MLCB57_18 possible transmembrane protein from Mycobacterium leprae (341 aa), FASTA score: (83.9% identity in [...]
fprB protein networkhttps://string-db.org/network/83332.Rv0886Rv0886, (MTCY31.14), len: 575 aa. Probable fprB,ferredoxin/ferredoxin-NADP(+) reductase (NADPH:adrenodoxin oxidoreductase), equivalent to O3306|MLCB57_19 ferredoxin/ferredoxin--NADP reductase fro [...]
Rv0887c protein networkhttps://string-db.org/network/83332.Rv0887cRv0887c, (MTCY31.15c), len: 152 aa. Conserved hypothetical protein, highly similar to others e.g. NP_436346.1|NC_003037 Hypothetical protein from Sinorhizobium meliloti (149 aa); AL132644|SCI8_26 [...]
spmT protein networkhttps://string-db.org/network/83332.Rv0888Probable exported protein; Catalyzes the cleavage of sphingomyelin, a major lipid in eukaryotic cells, into ceramide and phosphocholine, which are then utilized by M.tuberculosis as carbon, nitro [...]
citA protein networkhttps://string-db.org/network/83332.Rv0889cProbable citrate synthase II CitA; Rv0889c, (MTCY31.17c), len: 373 aa. Probable citA (alternate gene name: gltA), citrate synthase 2, highly similar to others e.g. CAB95899.1|AL359988 putative ci [...]
Rv0890c protein networkhttps://string-db.org/network/83332.Rv0890cRv0890c, (MTCY31.18c), len: 882 aa. Probable transcriptional regulatory protein, LuxR family, highly similar (but shorter 238 aa in N-terminus) to NP_302202.1|NC_002677 possible transcriptional r [...]
Rv0891c protein networkhttps://string-db.org/network/83332.Rv0891cRv0891c, (MTCY31.19c), len: 285 aa. Possible transcriptional regulator, highly similar in N-terminus to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa [...]
Rv0892 protein networkhttps://string-db.org/network/83332.Rv0892Rv0892, (MTCY31.20), len: 495 aa. Probable monooxygenase, highly similar to others e.g. NP_250787.1|NC_002516 probable flavin-binding monooxygenase from Pseudomonas aeruginosa (491 aa); CAB59668. [...]
Rv0893c protein networkhttps://string-db.org/network/83332.Rv0893cPossible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv0894 protein networkhttps://string-db.org/network/83332.Rv0894Rv0894, (MTCY31.22), len: 393 aa. Possible regulatory protein, LuxR family, highly similar in part to NP_302202.1|NC_002677 possible transcriptional regulator from Mycobacterium leprae (1106 aa). [...]
Rv0895 protein networkhttps://string-db.org/network/83332.Rv0895Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
gltA2 protein networkhttps://string-db.org/network/83332.Rv0896Rv0896, (MTCY31.24), len: 431 aa. Probable gltA2,citrate synthase 1, highly similar to O33066|NP_302405.1|NC_002677 citrate synthase 1 from Mycobacterium leprae (431 aa), FASTA scores: E(): 0, (9 [...]
Rv0897c protein networkhttps://string-db.org/network/83332.Rv0897cProbable oxidoreductase; Rv0897c, (MTCY31.25c), len: 535 aa. Possible oxidoreductase, similar to various oxidoreductases from diverse organisms e.g. CAB94055.1|AL358672 putative oxidoreductase fr [...]
Rv0898c protein networkhttps://string-db.org/network/83332.Rv0898cRv0898c, (MTCY31.26c), len: 87 aa. Conserved hypothetical protein, highly similar to CAC01589.1|AL391041 hypothetical protein from Streptomyces coelicolor (87 aa). Also shows some similarity to R [...]
ompA protein networkhttps://string-db.org/network/83332.Rv0899Outer membrane protein A OmpA; Probably plays a role in ammonia secretion that neutralizes the medium at pH 5.5, although it does not play a direct role in ammonia transport. The OmpA-like domain [...]
arfB protein networkhttps://string-db.org/network/83332.Rv0900Possible membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfB membrane protein family.
arfC protein networkhttps://string-db.org/network/83332.Rv0901Possible conserved exported or membrane protein; Required for wild-type expression of ArfA and ammonia secretion, not however part of an ammonia transporter. Belongs to the ArfC membrane protein [...]
prrB protein networkhttps://string-db.org/network/83332.Rv0902cTwo component sensor histidine kinase PrrB; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is ess [...]
prrA protein networkhttps://string-db.org/network/83332.Rv0903cTwo component response transcriptional regulatory protein PrrA; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Myco [...]
accD3 protein networkhttps://string-db.org/network/83332.Rv0904cPutative acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxy [...]
echA6 protein networkhttps://string-db.org/network/83332.Rv0905Possible enoyl-CoA hydratase EchA6 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Could possibly oxidize fatty acids using specific components.
Rv0906 protein networkhttps://string-db.org/network/83332.Rv0906Conserved protein; Rv0906, (MTCY31.34), len: 372 aa. Conserved protein,highly similar to others e.g. SC6A5.25|AL049485|T35416 hypothetical protein from Streptomyces coelicolor (370 aa),FASTA scor [...]
Rv0907 protein networkhttps://string-db.org/network/83332.Rv0907Conserved protein; Rv0907, (MTCY21C12.01), len: 532 aa. Conserved protein, possibly involved in cell wall biosynthesis: similar to many beta-lactamases, penicillin-binding proteins and hypothetic [...]
ctpE protein networkhttps://string-db.org/network/83332.Rv0908Probable metal cation transporter ATPase P-type CtpE; P-type ATPase involved in specific uptake of calcium.
Rv0909 protein networkhttps://string-db.org/network/83332.Rv0909Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv0910.
Rv0910 protein networkhttps://string-db.org/network/83332.Rv0910Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression [...]
Rv0911 protein networkhttps://string-db.org/network/83332.Rv0911Conserved protein; Rv0911, (MTCY21C12.05), len: 257 aa. Conserved protein, showing similarity with hydroxylases and hypothetical proteins e.g. T35325 probable hydroxylase from Streptomyces coelic [...]
Rv0912 protein networkhttps://string-db.org/network/83332.Rv0912Rv0912, (MTCY21C12.06), len: 149 aa. Probable conserved transmembrane protein, equivalent to Q50121|NP_302397.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (144 aa), FASTA [...]
Rv0913c protein networkhttps://string-db.org/network/83332.Rv0913cPossible dioxygenase; Rv0913c, (MTCY21C12.07c), len: 502 aa. Possible dioxygenase, showing similarity with others e.g. AAK38744.1|AY029525 carotenoid 9,10-9',10' cleavage dioxygenase from Phaseol [...]
Rv0914c protein networkhttps://string-db.org/network/83332.Rv0914cRv0914c, (MTCY21C12.08c), len: 412 aa. Possible lipid carrier protein or keto acyl-CoA thiolase, highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 a [...]
PPE14 protein networkhttps://string-db.org/network/83332.Rv0915cRv0915c, (MTCY21C12.09c), len: 423 aa. PPE14 (alternate gene name: MTB41). Member of the Mycobacterium tuberculosis PPE family (see citation below), highly similar to many e.g. Rv1807 from Mycoba [...]
PE7 protein networkhttps://string-db.org/network/83332.Rv0916cRv0916c, (MTCY21C12.10c), len: 99 aa. PE7 (alternate gene name: MTB10). Member of the Mycobacterium tuberculosis PE family (see citations below), similar to many e.g. Rv1788 from Mycobacterium tu [...]
betP protein networkhttps://string-db.org/network/83332.Rv0917Rv0917, (MTCY21C12.11), len: 593 aa. Possible betP,glycine betaine transporter, integral membrane protein,highly similar to many transporters, mainly glycine betaine transporters, e.g. P54582|BET [...]
Rv0918 protein networkhttps://string-db.org/network/83332.Rv0918Conserved protein; Rv0918, (MTCY21C12.12), len: 158 aa. Conserved protein, similar in part to Q50116 hypothetical protein from Mycobacterium leprae (44 aa), FASTA scores: opt: 132,E(): 0.0055, (6 [...]
Rv0919 protein networkhttps://string-db.org/network/83332.Rv0919GCN5-related N-acetyltransferase; Rv0919, (MTCY21C12.13), len: 166 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Some similarit [...]
Rv0920c protein networkhttps://string-db.org/network/83332.Rv0920cProbable transposase; Required for the transposition of the insertion element.
Rv0921 protein networkhttps://string-db.org/network/83332.Rv0921Possible resolvase; Rv0921, (MTCY21C12.15), len: 193 aa. Possible resolvase for IS1535, highly similar to many bacterial resolvases e.g. MTCY274.17c|YX1C_MYCTU Q10831 from Mycobacterium tuberculo [...]
Rv0922 protein networkhttps://string-db.org/network/83332.Rv0922Possible transposase; Rv0922, (MTCY21C12.16), len: 550 aa. Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scor [...]
Rv0923c protein networkhttps://string-db.org/network/83332.Rv0923cConserved hypothetical protein; Rv0923c, (MTCY21C12.17c), len: 354 aa. Conserved hypothetical protein, showing similarity with C-terminal part of AF034138|AF034138_7|yjoB hypothetical protein fro [...]
mntH protein networkhttps://string-db.org/network/83332.Rv0924cDivalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP); H(+)-stimulated, divalent metal cation uptake system. Transports zinc and iron. Can also interact with manganese and copp [...]
Rv0925c protein networkhttps://string-db.org/network/83332.Rv0925cConserved protein; Rv0925c, (MTCY21C12.19c), len: 245 aa. Conserved protein, similar to AL132991|SCF55_19 hypothetical protein from Streptomyces coelicolor (197 aa), FASTA scores: opt: 459, E(): [...]
Rv0926c protein networkhttps://string-db.org/network/83332.Rv0926cConserved hypothetical protein; Rv0926c, (MTCY21C12.20c), len: 358 aa. Conserved hypothetical protein, similar to Rv1059 conserved hypothetical protein from Mycobacterium tuberculosis (354 aa). A [...]
Rv0927c protein networkhttps://string-db.org/network/83332.Rv0927cRv0927c, (MTCY21C12.21c), len: 263 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases, notably 7-alpha-hydroxysteroid dehydrogenases and glucose 1-dehy [...]
pstS3 protein networkhttps://string-db.org/network/83332.Rv0928Periplasmic phosphate-binding lipoprotein PstS3 (PBP-3) (PstS3) (PHOS1); Functions in inorganic phosphate uptake, is probably the main carrier for phosphate uptake, it is the most highly expresse [...]
pstC2 protein networkhttps://string-db.org/network/83332.Rv0929Phosphate-transport integral membrane ABC transporter PstC2; Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate [...]
pstA1 protein networkhttps://string-db.org/network/83332.Rv0930Probable phosphate-transport integral membrane ABC transporter PstA1; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the subst [...]
pknD protein networkhttps://string-db.org/network/83332.Rv0931cTransmembrane serine/threonine-protein kinase D PknD (protein kinase D) (STPK D); Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endoth [...]
pstS2 protein networkhttps://string-db.org/network/83332.Rv0932cPeriplasmic phosphate-binding lipoprotein PstS2 (PBP-2) (PstS2); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Part of the ABC [...]
pstB protein networkhttps://string-db.org/network/83332.Rv0933Phosphate-transport ATP-binding protein ABC transporter PstB; Part of the ABC transporter complex PstSACB involved in phosphate import (Probable). Responsible for energy coupling to the transport [...]
pstS1 protein networkhttps://string-db.org/network/83332.Rv0934Periplasmic phosphate-binding lipoprotein PstS1 (PBP-1) (PstS1); Functions in inorganic phosphate uptake, although probably not the main uptake protein under phosphate starvation. Binds phosphate [...]
pstC1 protein networkhttps://string-db.org/network/83332.Rv0935Phosphate-transport integral membrane ABC transporter PstC1; Part of the ABC transporter complex PstSACB involved in phosphate import; probably responsible for the translocation of the substrate [...]
pstA2 protein networkhttps://string-db.org/network/83332.Rv0936Phosphate-transport integral membrane ABC transporter PstA2; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate acro [...]
mku protein networkhttps://string-db.org/network/83332.Rv0937cDNA end-binding protein, Mku; With LigD forms a non-homologous end joining (NHEJ) repair enzyme. Binds linear dsDNA with 5'- and 3'-overhangs but not closed circular dsDNA nor ssDNA. One dimer bi [...]
ligD protein networkhttps://string-db.org/network/83332.Rv0938Multifunctional non-homologous end joining DNA repair protein LigD; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidel [...]
Rv0939 protein networkhttps://string-db.org/network/83332.Rv0939Rv0939, (MTCY10D7.35c), len: 644 aa. Possible bifunctional enzyme, including 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase activity, and cyclase/dehydrase activity. N-terminal part similar to man [...]
Rv0940c protein networkhttps://string-db.org/network/83332.Rv0940cRv0940c, (MTCY10D7.34), len: 288 aa. Possible oxidoreductase, similar to hypothetical proteins and oxidoreductases e.g. AAK38097.1|AF323606_3|AF323606 putative F420-dependent dehydrogenase from R [...]
Rv0941c protein networkhttps://string-db.org/network/83332.Rv0941cRv0941c, (MTCY10D7.33), len: 257 aa. Conserved hypothetical protein, showing some similarity with parts of several hypothetical proteins from Streptomyces coelicolor e.g. AL035161|SC9C7_20 (860 a [...]
Rv0942 protein networkhttps://string-db.org/network/83332.Rv0942Hypothetical protein; Rv0942, (MTCY10D7.32c), len: 92 aa. Hypothetical unknown protein.
Rv0943c protein networkhttps://string-db.org/network/83332.Rv0943cProbable monooxygenase; Rv0943c, (MTCY10D7.31), len: 346 aa. Possible monooxygenase, similar in part to others e.g. NP_250229.1|NC_002516 probable flavin-containing monooxygenase from Pseudomonas [...]
fpg2 protein networkhttps://string-db.org/network/83332.Rv0944Rv0944, (MTCY10D7.30c), len: 158 aa. Possible formamidopyrimidine-DNA glycosylase, similar to C-terminus of formamidopyrimidine-DNA glycosylases e.g. CAB63194.1|AL133469 putative formamidopyrimid [...]
Rv0945 protein networkhttps://string-db.org/network/83332.Rv0945Rv0945, (MTCY10D7.29c), len: 253 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases e.g. NP_346338.1|NC_003028 oxidoreductase (short chain dehydrogenas [...]
pgi protein networkhttps://string-db.org/network/83332.Rv0946cGlucose-6-phosphate isomerase; Rv0946c, (MTCY10D7.28), len: 553 aa. Probable pgi,glucose-6-phosphate isomerase, equivalent to NP_301236.1|NC_002677 glucose-6-phosphate isomerase from Mycobacteriu [...]
Rv0948c protein networkhttps://string-db.org/network/83332.Rv0948cProbable mycolyl transferase, pseudogene; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
uvrD1 protein networkhttps://string-db.org/network/83332.Rv0949Probable ATP-dependent DNA helicase II UvrD1; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. A minimal tail of 18 nt is required for activity. Also [...]
Rv0950c protein networkhttps://string-db.org/network/83332.Rv0950cRv0950c, (MTCY10D7.24), len: 332 aa. Conserved hypothetical protein, highly similar to AL035500|MLCL373.02c|T45433 hypothetical protein from Mycobacterium leprae (343 aa), FASTA scores: opt: 1500 [...]
sucC protein networkhttps://string-db.org/network/83332.Rv0951Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either [...]
sucD protein networkhttps://string-db.org/network/83332.Rv0952Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of eith [...]
Rv0953c protein networkhttps://string-db.org/network/83332.Rv0953cRv0953c, (MTCY10D7.21), len: 282 aa. Possible oxidoreductase, equivalent to CAA48222.1|X68102 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (166 aa). Similar to several hy [...]
Rv0954 protein networkhttps://string-db.org/network/83332.Rv0954Rv0954, (MTCY10D7.20c), len: 303 aa. Probable conserved transmembrane protein, highly similar to 34KD_MYCPA|Q04959 34 kDa antigenic protein from Mycobacterium paratuberculosis (298 aa), FASTA sco [...]
Rv0955 protein networkhttps://string-db.org/network/83332.Rv0955Rv0955, (MTCY10D7.19c), len: 455 aa. Probable conserved integral membrane protein, highly similar to AL035500|MLCL373_6 putative membrane protein from Mycobacterium leprae (430 aa), FASTA score: [...]
purN protein networkhttps://string-db.org/network/83332.Rv0956Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylg [...]
purH protein networkhttps://string-db.org/network/83332.Rv0957Phosphoribosylaminoimidazolecarboxamide formyltransferase; Rv0957, (MTCY10D7.17c), len: 523 aa. Probable purH,bifunctional purine biosynthesis protein including 5'-phosphoribosyl-5-aminoimidazole [...]
Rv0958 protein networkhttps://string-db.org/network/83332.Rv0958Rv0958, (MTCY10D7.16c), len: 459 aa. Possible magnesium chelatase, similar to others (especially in N-terminal parts) e.g. NP_296313.1|NC_001263|AE002088_10 putative magnesium protoporphyrin chel [...]
Rv0959 protein networkhttps://string-db.org/network/83332.Rv0959Rv0959, (MTCY10D7.15c), len: 672 aa. Conserved hypothetical protein, similar to AE002069|AE002069_12 hypothetical protein from Deinococcus radiodurans (403 aa),FASTA scores: opt: 395, E(): 1.3e-1 [...]
vapB9 protein networkhttps://string-db.org/network/83332.Rv0959APossible antitoxin VapB9; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC9.
vapC9 protein networkhttps://string-db.org/network/83332.Rv0960Possible toxin VapC9; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB9 (By similarity). Belongs to the PINc/VapC protein family.
Rv0961 protein networkhttps://string-db.org/network/83332.Rv0961Rv0961, (MTCY10D7.13c), len: 115 aa. Probable integral membrane protein.
lprP protein networkhttps://string-db.org/network/83332.Rv0962cRv0962c, (MTCY10D7.12), len: 224 aa. Possible lprP,lipoprotein. Contains possible N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment [...]
Rv0963c protein networkhttps://string-db.org/network/83332.Rv0963cRv0963c, (MTCCY10D7.11), len: 266 aa. Conserved hypothetical protein, similar in part to other conserved hypothetical proteins from Mycobacterium tuberculosis e.g. Rv2797c|MTCY16B7.46 (562 aa), F [...]
Rv0964c protein networkhttps://string-db.org/network/83332.Rv0964cHypothetical protein; Rv0964c, (MTCY10D7.10), len: 160 aa. Hypothetical unknown protein. Equivalent to AAK45241.1 from Mycobacterium tuberculosis strain CDC1551 (138 aa) but longer 22 aa.
Rv0965c protein networkhttps://string-db.org/network/83332.Rv0965cRv0965c, (MTCY10D7.09), len: 139 aa. Conserved hypothetical protein, showing weak similarity with Rv2798c|MTCY16B7.45 conserved hypothetical protein from Mycobacterium tuberculosis (108 aa), FAST [...]
Rv0966c protein networkhttps://string-db.org/network/83332.Rv0966cConserved protein; Rv0966c, (MTCY10D7.08), len: 200 aa. Conserved protein, equivalent to AL035500|MLCL373_12 conserved hypothetical protein from Mycobacterium leprae (200 aa),FASTA scores: opt: 1 [...]
csoR protein networkhttps://string-db.org/network/83332.Rv0967Copper-sensitive operon repressor CsoR; Copper-sensitive repressor that has a key role in copper homeostasis. It is part of the cso operon involved in the cellular response to increasing concentr [...]
Rv0968 protein networkhttps://string-db.org/network/83332.Rv0968Conserved protein; Rv0968, (MTCY10D7.06c), len: 98 aa. Conserved protein, part of cso operon, similar to NP_301579.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (92 aa). Al [...]
ctpV protein networkhttps://string-db.org/network/83332.Rv0969Probable metal cation transporter P-type ATPase CtpV; Necessary for copper homeostasis and likely functions as a copper exporter. Also required for full virulence.
Rv0970 protein networkhttps://string-db.org/network/83332.Rv0970Rv0970, (MTCY10D7.04c), len: 210 aa. Probable conserved integral membrane protein, part of cso operon,equivalent to NP_302348.1|NC_002677 probable integral membrane protein from Mycobacterium lep [...]
echA7 protein networkhttps://string-db.org/network/83332.Rv0971cProbable enoyl-CoA hydratase EchA7 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv0971c, (MTCY10D7.03), len: 269 aa. Probable echA7,enoyl-CoA hydratase, similar to many e.g. CAB9 [...]
fadE12 protein networkhttps://string-db.org/network/83332.Rv0972cRv0972c, (MTCY10D7.02), len: 388 aa. fadE12,acyl-CoA dehydrogenase, highly similar to many e.g. CAB95893.1|AL359988 putative acyl CoA dehydrogenase from Streptomyces coelicolor (382 aa); P45857|A [...]
accA2 protein networkhttps://string-db.org/network/83332.Rv0973cRv0973c, (MTV044.01c, MTCY10D7.01), len: 667 aa. Probable accA2 (alternate gene name: bccA),acetyl-/propionyl-coenzyme A carboxylase (alpha subunit) [includes: biotin carboxylase; biotin carboxyl [...]
accD2 protein networkhttps://string-db.org/network/83332.Rv0974cRv0974c, (MTV044.02c), len: 529 aa. Probable accD2,acetyl-/propionyl-CoA carboxylase (beta subunit), highly similar to many e.g. CAB95891.1|AL35998 putative acetyl/propionyl CoA carboxylase beta [...]
fadE13 protein networkhttps://string-db.org/network/83332.Rv0975cRv0975c, (MTV044.03c), len: 382 aa. Probable fadE13,acyl-CoA dehydrogenase, highly similar to many e.g. T35427 probable acyl-CoA dehydrogenase from Streptomyces coelicolor (382 aa); M74096|HUMACA [...]
Rv0976c protein networkhttps://string-db.org/network/83332.Rv0976cRv0976c, (MTV044.04c), len: 560 aa. Conserved hypothetical protein, highly similar to others e.g. CAB95890.1|AL359988 conserved hypothetical protein from Streptomyces coelicolor (558 aa); P_25157 [...]
PE_PGRS16 protein networkhttps://string-db.org/network/83332.Rv0977PE-PGRS family protein PE_PGRS16; Rv0977, (MTV044.05), len: 923 aa. PE_PGRS16, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly [...]
PE_PGRS17 protein networkhttps://string-db.org/network/83332.Rv0978cPE-PGRS family protein PE_PGRS17; Induces maturation and activation of human dendritic cells (DCs), via TLR2-dependent activation of ERK1/2, p38 MAPK, and NF-kappa- B signaling pathways, and enha [...]
rpmF protein networkhttps://string-db.org/network/83332.Rv0979ARv0979A, len: 57 aa. rpmF, 50S ribosomal protein L32, similar to others e.g. rpmF|Q9RL50 probable 50S ribosomal protein from Streptomyces coelicolor (56 aa),FASTA scores: E(): 5.1e-09, (63.45% id [...]
Rv0979c protein networkhttps://string-db.org/network/83332.Rv0979cHypothetical protein; Rv0979c, (MTV044.07c), len: 64 aa (unlikely ORF). Hypothetical unknown protein. Start codon changed since first submission (-44 aa).
PE_PGRS18 protein networkhttps://string-db.org/network/83332.Rv0980cPE-PGRS family protein PE_PGRS18; Rv0980c, (MTV044.08c), len: 457 aa. PE_PGRS18,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
mprA protein networkhttps://string-db.org/network/83332.Rv0981Response regulator MprA; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for [...]
mprB protein networkhttps://string-db.org/network/83332.Rv0982Two component sensor kinase MprB; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is req [...]
pepD protein networkhttps://string-db.org/network/83332.Rv0983Rv0983, (MTV044.11), len: 464 aa. Probable pepD (alternate gene name: mtb32b), secreted or membrane serine protease (see citation below), equivalent (but longer 18 aa in N-terminus) to AL035500|M [...]
moaB2 protein networkhttps://string-db.org/network/83332.Rv0984MoCF_biosynth domain-containing protein; Rv0984, (MTV044.12), len: 181 aa. Possible moaB2,pterin-4-alpha-carbinolamine dehydratase, highly similar to NP_301253.1|NC_002677 putative molybdenum cof [...]
mscL protein networkhttps://string-db.org/network/83332.Rv0985cPossible large-conductance ion mechanosensitive channel MscL; Channel that opens in response to stretch forces in the membrane lipid bilayer. The force required to trigger channel opening depends [...]
Rv0986 protein networkhttps://string-db.org/network/83332.Rv0986Rv0986, (MTV044.14), len: 248 aa. Probable ATP-binding protein ABC transporter supposedly involved in transport of adhesion component (see citation below),highly similar to many ATP-binding prote [...]
Rv0987 protein networkhttps://string-db.org/network/83332.Rv0987Rv0987, (MTV044.15, MTCI237.01), len: 855 aa. Probable transmembrane protein ABC transporter supposedly involved in transport of adhesion component (see citation below), whose N-terminus shows si [...]
Rv0988 protein networkhttps://string-db.org/network/83332.Rv0988Rv0988, (MTCI237.02), len: 386 aa. Possible conserved exported protein, with potential N-terminal signal sequence, similar (except in N-terminus) to O32737|L63540 ATTH protein from Agrobacterium [...]
grcC2 protein networkhttps://string-db.org/network/83332.Rv0989cProbable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase); Rv0989c, (MTCI237.03c), len: 325 aa. Probable grcC2,polyprenyl diphosphate synthetase, highly similar to NP_3 [...]
Rv0990c protein networkhttps://string-db.org/network/83332.Rv0990cHypothetical protein; Rv0990c, (MTCI237.04c), len: 218 aa. Hypothetical unknown protein.
Rv0991c protein networkhttps://string-db.org/network/83332.Rv0991cRv0991c, (MTCI237.05c), len: 110 aa. Conserved ser-rich protein (especially in C-terminus), highly similar to N-terminus of NP_301255.1|NC_002677 conserved hypothetical protein (Ser-rich C-termin [...]
Rv0992c protein networkhttps://string-db.org/network/83332.Rv0992cRv0992c, (MTCI237.06c), len: 197 aa. Conserved hypothetical protein, equivalent to NP_301256.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (197 aa). Also similar, except in [...]
galU protein networkhttps://string-db.org/network/83332.Rv0993Rv0993, (MTCI237.07), len: 306 aa. GalU,UTP--glucose-1-phosphate uridylyltransferase, equivalent to AL035500|MLCL373_22 putative UTP-glucose-1-phosphate uridylyltransferase from Mycobacterium lep [...]
moeA1 protein networkhttps://string-db.org/network/83332.Rv0994Probable molybdopterin biosynthesis protein MoeA1; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP; Belongs to the MoeA family.
rimJ protein networkhttps://string-db.org/network/83332.Rv0995[ribosomal protein S5]-alanine N-acetyltransferase; Rv0995, (MTCI237.09), len: 203 aa. RimJ,ribosomal-protein-alanine acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. S [...]
Rv0996 protein networkhttps://string-db.org/network/83332.Rv0996Rv0996, (MTCI237.10), len: 358 aa. Probable conserved transmembrane protein, equivalent to AL035500|MLCL373_25 putative membrane protein from Mycobacterium leprae (342 aa), FASTA scores: (66.4% i [...]
Rv0997 protein networkhttps://string-db.org/network/83332.Rv0997Hypothetical protein; Rv0997, (MTCI237.11), len: 143 aa. Hypothetical unknown protein, equivalent to AAK45276.1 from Mycobacterium tuberculosis strain CDC1551 (87 aa) but longer 56 aa.
Rv0998 protein networkhttps://string-db.org/network/83332.Rv0998Conserved hypothetical protein; Catalyzes specifically the acetylation of the epsilon-amino group of a highly conserved lysine residue in acetyl-CoA synthetase (ACS). This acetylation results in [...]
Rv0999 protein networkhttps://string-db.org/network/83332.Rv0999Unknown protein; Rv0999, (MTCI237.13), len: 252 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
Rv1000c protein networkhttps://string-db.org/network/83332.Rv1000cRv1000c, len: 205 aa. Conserved hypothetical protein, equivalent to ML0190|NP_301263.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (205 aa). Also highly similar to SC5F8.12 [...]
arcA protein networkhttps://string-db.org/network/83332.Rv1001Rv1001, (MTCI237.16), len: 402 aa. Probable arcA,arginine deiminase, similar to e.g. ARCA_PSEAE|P13981 arginine deiminase (417 aa), fasta scores: opt: 581, E(): 1.4e-31, (39.4% identity in 411 aa [...]
pmt protein networkhttps://string-db.org/network/83332.Rv1002cConserved membrane protein; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins (Probable). Mannosylates an artificial substrate, probably on a Thr residue, upon expression in [...]
rsmI protein networkhttps://string-db.org/network/83332.Rv1003Conserved protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA; Belongs to the methyltransferase superfamily. RsmI family.
Rv1004c protein networkhttps://string-db.org/network/83332.Rv1004cProbable membrane protein; Rv1004c, (MTCI237.20c), len: 419 aa. Probable membrane protein. Contains repetitive sequences, which have similarities with elastin, and possible N-terminal signal sequ [...]
pabB protein networkhttps://string-db.org/network/83332.Rv1005cRv1005c, (MTCI237.22c), len: 458 aa (Start-site not certain). Probable PabD, para-aminobenzoate synthase component I. Similar to PABB_ECOLI|P05041 para-aminobenzoate synthase component I from Esc [...]
Rv1006 protein networkhttps://string-db.org/network/83332.Rv1006Unknown protein; Rv1006, (MTCI237.23), len: 567 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
metS protein networkhttps://string-db.org/network/83332.Rv1007cMethionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tR [...]
tatD protein networkhttps://string-db.org/network/83332.Rv1008Probable deoxyribonuclease TatD (YJJV protein); Rv1008, (MTCI237.25), len: 264 aa. Probable tatD (alternate gene name: yjjV), deoxyribonuclease, component of twin arginine translocation protein e [...]
rpfB protein networkhttps://string-db.org/network/83332.Rv1009Probable resuscitation-promoting factor RpfB; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little t [...]
ksgA protein networkhttps://string-db.org/network/83332.Rv1010Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S part [...]
ispE protein networkhttps://string-db.org/network/83332.Rv10114-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. I [...]
Rv1012 protein networkhttps://string-db.org/network/83332.Rv1012Hypothetical protein; Rv1012, (MTCI237.29), len: 97 aa. Hypothetical unknown protein.
pks16 protein networkhttps://string-db.org/network/83332.Rv1013Rv1013, (MTCI237.30-MTCY10G2.36c), len: 544 aa. Putative pks16, polyketide synthase, similar to many e.g. N-terminus of Q50857|U24657 saframycin MX1 synthetase B (1770 aa), FASTA scores: opt: 526 [...]
pth protein networkhttps://string-db.org/network/83332.Rv1014cProbable peptidyl-tRNA hydrolase Pth; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
rplY protein networkhttps://string-db.org/network/83332.Rv1015c50S ribosomal protein L25 RplY; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL [...]
lpqT protein networkhttps://string-db.org/network/83332.Rv1016cRv1016c, (MTCY10G2.33), len: 226 aa. Probable lpqT,conserved lipoprotein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv0040c|Y0H3_MYCTU|P71697 Proline rich 28 kDA an [...]
prsA protein networkhttps://string-db.org/network/83332.Rv1017cRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) and of the decaprenylphosphoryl-arabinose (DPA), an essen [...]
glmU protein networkhttps://string-db.org/network/83332.Rv1018cProbable UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal [...]
Rv1019 protein networkhttps://string-db.org/network/83332.Rv1019Probable transcriptional regulatory protein (probably TetR-family); Rv1019, (MTCY10G2.30c), len: 197 aa. Probable transcriptional regulator, similar to many memebers of the TetR family e.g. MTCY7 [...]
mfd protein networkhttps://string-db.org/network/83332.Rv1020Probable transcription-repair coupling factor Mfd (TRCF); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP [...]
mazG protein networkhttps://string-db.org/network/83332.Rv1021Conserved protein; Required to maintain the full capacity of the mycobacterium to respond to oxidative stress via the degradation of oxidation-induced damaged nucleotides. Hydrolyzes all canonica [...]
lpqU protein networkhttps://string-db.org/network/83332.Rv1022Rv1022, (MTCY10G2.27c), len: 243 aa. Probable lpqU conserved lipoprotein. Similar to Mycobacterium tuberculosis hypothetical protein Rv1230c|MTV006.02C, FASTA scores: E(): 2.8e-18, (37.9% identit [...]
eno protein networkhttps://string-db.org/network/83332.Rv1023Probable enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enola [...]
Rv1024 protein networkhttps://string-db.org/network/83332.Rv1024Rv1024, (MTCY10G2.25c), len: 228 aa. Possible conserved membrane protein, with a hydrophobic region from aa 83-101. Equivalent to ML0256|NP_301311.1|NC_002677 possible conserved membrane protein [...]
Rv1025 protein networkhttps://string-db.org/network/83332.Rv1025Conserved protein; Rv1025, (MTCY10G2.24c), len: 155 aa. Conserved protein, similar to hypothetical protein AE001768|AE001768_4 Thermotoga maritima (170 aa) FASTA scores: opt: 254, E(): 9.5e-10, ( [...]
ppx2 protein networkhttps://string-db.org/network/83332.Rv1026Conserved protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Prefers long-chain length polyphosphates as substrates ( [...]
kdpE protein networkhttps://string-db.org/network/83332.Rv1027cProbable transcriptional regulatory protein KdpE; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Upon phosphorylation by KdpD, functions as [...]
kdpF protein networkhttps://string-db.org/network/83332.Rv1028ARv1028A, len: 30 aa. Probable kdpF, membrane protein, showing similarity with P36937|KDPF_ECOLI|B0698.1 protein KDPF from Escherichia coli strain K12 (see citation below) (27% identity); and KdpF [...]
kdpD protein networkhttps://string-db.org/network/83332.Rv1028cProbable sensor protein KdpD; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon. Functions as a sensor protein kinase which is autophosphorylate [...]
kdpA protein networkhttps://string-db.org/network/83332.Rv1029Potassium-transporting ATPase potassium-binding subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electroge [...]
kdpB protein networkhttps://string-db.org/network/83332.Rv1030Potassium-transporting ATPase ATP-binding subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic tr [...]
kdpC protein networkhttps://string-db.org/network/83332.Rv1031Potassium-transporting ATPase KdpC subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport [...]
trcS protein networkhttps://string-db.org/network/83332.Rv1032cRv1032c, (MTCY10G2.17), len: 509 aa. TrcS, two component sensor histidine kinase protein (see citations below), similar to YV16_MYCLE|P54883 probable sensor-like histidine kinase from Mycobacteri [...]
trcR protein networkhttps://string-db.org/network/83332.Rv1033cRv1033c, (MTCY10G2.16), len: 257 aa. TrcR,two-component regulatory protein (see citations below),similar to Q50825 two component response regulator from Mycobacterium tuberculosis (234 aa), FASTA [...]
Rv1034c protein networkhttps://string-db.org/network/83332.Rv1034cProbable transposase (fragment); Rv1034c, (MTCY10G2.15), len: 129 aa. Probable IS1560 transposase fragment, similar to part of Rv3387|E1202305|MTV004.45 (225 aa) (65.1% identity in 129 aa overlap [...]
Rv1035c protein networkhttps://string-db.org/network/83332.Rv1035cProbable transposase (fragment); Rv1035c, (MTCY10G2.14), len: 228 aa. Probable IS1560 transposase fragment, similar to parts of Rv3387|E1202305|MTV004.45 (225 aa) (47.8% identity in 67 aa overlap [...]
Rv1036c protein networkhttps://string-db.org/network/83332.Rv1036cRv1036c, (MTCY10G2.13), len: 112 aa. Probable IS1560 transposase fragment, similar to part of Rv3386|E1202304|MTV004.44 (234 aa) (82.8% identity in 87 aa overlap).
esxI protein networkhttps://string-db.org/network/83332.Rv1037cRv1037c, (MTCY10G2.12), len: 94 aa. EsxI, ESAT-6 like protein (see citations below), highly similar to Q49946|ES6X_MYCLE|U1756D putative ESAT-6 like protein X from Mycobacterium leprae (95 aa), F [...]
esxJ protein networkhttps://string-db.org/network/83332.Rv1038cRv1038c, (MT1067, MTCY10G2.11), len: 98 aa. EsxJ,ESAT-6 like protein (see Gey Van Pittius et al., 2001),similar to Q49945|U1756C, Mycobacterium leprae (100 aa),FASTA scores: opt: 375, E(): 7.7e-2 [...]
PPE15 protein networkhttps://string-db.org/network/83332.Rv1039cPPE family protein PPE15; May play a critical role in the homeostasis of triacylglycerol-containing lipid droplets in M.tuberculosis and influence the entry of the pathogen into a dormant state.
PE8 protein networkhttps://string-db.org/network/83332.Rv1040cRv1040c, (MTCY10G2.09), len: 275 aa. PE8, Member of the Mycobacterium tuberculosis PE family (see citation below), most similar to AL008967|MTV002_34 Mycobacterium tuberculosis H37Rv (275 aa), FA [...]
Rv1041c protein networkhttps://string-db.org/network/83332.Rv1041cRv1041c, (MTCY10G2.08), len: 287 aa. Probable is like-2 transposase, overlaps MTCY10G2.07. Similar to Q00430|X53945 insertion element IS869 hypothetical protein from Agrobacterium tumefaciens (18 [...]
Rv1042c protein networkhttps://string-db.org/network/83332.Rv1042cRv1042c, (MTCY10G2.07), len: 135 aa. Probable is like-2 transposase, similar to Q50761 transposase from Mycobacterium tuberculosis (308 aa), FASTA scores: opt: 823, E(): 0, (99.1% identity in 117 [...]
Rv1043c protein networkhttps://string-db.org/network/83332.Rv1043cRv1043c, (MTCY10G2.06), len: 341 aa. Conserved hypothetical protein similar to AL096872|SC5F7.08 putative lipoate-protein ligase from Streptomyces coelicolor (362 aa), FASTA scores: opt: 206, E() [...]
Rv1044 protein networkhttps://string-db.org/network/83332.Rv1044Rv1044, (MTCY10G2.05c), len: 207 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein MTCY06G11.02C|P96837 (289 aa), fasta scores: E(): 8.9e-06, (30.7% i [...]
Rv1045 protein networkhttps://string-db.org/network/83332.Rv1045Hypothetical protein; Rv1045, (MTCY10G2.04c), len: 293 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1046c protein networkhttps://string-db.org/network/83332.Rv1046cHypothetical protein; Rv1046c, (MTCY10G2.03), len: 174 aa. Hypothetical unknown protein. Start changed since first submission (-65 aa). This region is a possible MT-complex-specific genomic islan [...]
Rv1047 protein networkhttps://string-db.org/network/83332.Rv1047Probable transposase; Required for the transposition of the insertion element.
Rv1048c protein networkhttps://string-db.org/network/83332.Rv1048cHypothetical protein; Rv1048c, (MTV017.01c-MTCY10G2.01), len: 371 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1049 protein networkhttps://string-db.org/network/83332.Rv1049Rv1049, (MTV017.02), len: 148 aa. Probable transcriptional repressor protein, similar to many e.g. P74870 negative regulator of EMR locus EMR from Salmonella typhimurium (149 aa), FASTA scores: o [...]
Rv1050 protein networkhttps://string-db.org/network/83332.Rv1050Rv1050, (MTV017.03), len: 301 aa. Probable oxidoreductase similar to many e.g. Rv1543|MTCY48.22C|Q10783 putative oxidoreductase CY48.22C (341 aa), FASTA scores: opt: 462, E(): 3e-22, (33.6% ident [...]
Rv1051c protein networkhttps://string-db.org/network/83332.Rv1051cRv1051c, (MTV017.04c), len: 251 aa. Conserved hypothetical protein, similar to LLU36837|U36837.1 protein encoded by Lactococcus lactis plasmid pNP40 (298 aa), FASTA scores: opt: 194, E(): 3.5e-06 [...]
Rv1052 protein networkhttps://string-db.org/network/83332.Rv1052Hypothetical protein; Rv1052, (MTV017.05), len: 129 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1053c protein networkhttps://string-db.org/network/83332.Rv1053cHypothetical protein; Rv1053c, (MTV017.06c), len: 91 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1054 protein networkhttps://string-db.org/network/83332.Rv1054Rv1054, (MTV017.07), len: 104 aa. Probable integrase (fragment), similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tuberculosis (151 a [...]
Rv1055 protein networkhttps://string-db.org/network/83332.Rv1055Rv1055, (MTV017.08), len: 44 aa. Possible integrase (fragment); first 49 aa similar to Rv2309c|MTCY3G12_25|Z79702 hypothetical protein (shows similarity to integrases) from Mycobacterium tubercul [...]
Rv1056 protein networkhttps://string-db.org/network/83332.Rv1056Conserved protein; Rv1056, (MTV017.09), len: 254 aa. Conserved protein,some similarity in C-terminal region of Rv0140|MTCI5.14|Z92770 Mycobacterium tuberculosis (126 aa),FASTA scores: opt: 254, E [...]
Rv1057 protein networkhttps://string-db.org/network/83332.Rv1057Rv1057, (MTV017.10), len: 393 aa. Conserved hypothetical protein, some similarity to X84710|MMSAG_1 surface antigen of Methanosarcina mazeii (491 aa), FASTA scores: opt: 363, E():6.2e-15, (31.3% [...]
fadD14 protein networkhttps://string-db.org/network/83332.Rv1058Fatty-acid-CoA ligase FadD14; Rv1058, (MTV017.11), len: 543 aa. Probable fadD14,medium-chain fatty-acid-CoA synthetase, highly similar to many e.g. CAC32346.1|AL583945 putative fatty acid CoA lig [...]
Rv1059 protein networkhttps://string-db.org/network/83332.Rv1059Conserved protein; Rv1059, (MTV017.12), len: 354 aa. Conserved protein,similar to Rv0926c|MTCY21C12.20c hypothetical protein from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 338, E(): [...]
Rv1060 protein networkhttps://string-db.org/network/83332.Rv1060Unknown protein; Rv1060, (MTV017.13), len: 157 aa. Unknown protein.
Rv1061 protein networkhttps://string-db.org/network/83332.Rv1061Conserved protein; Rv1061, (MTV017.14), len: 287 aa. Conserved protein,similar to hypothetical proteins from various bacteria e.g. D64002|SYCSLRD_75 Synechocystis sp. PCC6803 (304 aa),FASTA score [...]
Rv1062 protein networkhttps://string-db.org/network/83332.Rv1062Rv1062, (MTV017.15), len: 285 aa. Conserved hypothetical protein, some similarity to AL079356|SC6G9_10 hypothetical protein in Streptomyces coelicolor (289 aa),FASTA scores: opt: 556, E(): 1.2e-2 [...]
Rv1063c protein networkhttps://string-db.org/network/83332.Rv1063cRv1063c, (MTV017.16c), len: 360 aa. Conserved hypothetical protein, similar to P37053|YCHK_ECOLI hypothetical protein from Escherichia coli (314 aa), FASTA scores: opt: 487, E(): 7.2e-23, (32.7% [...]
lpqV protein networkhttps://string-db.org/network/83332.Rv1064cPossible lipoprotein LpqV; Rv1064c, (MTV017.17c), len: 139 aa. Possible lipoprotein LpqV. Has N-terminal signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipi [...]
Rv1065 protein networkhttps://string-db.org/network/83332.Rv1065Rv1065, (MTV017.18), len: 188 aa. Conserved hypothetical protein, some similarity to AL0209|SC4H8_11 hypothetical protein from Streptomyces coelicolor (182 aa),FASTA scores: opt: 156, E(): 0.0011 [...]
Rv1066 protein networkhttps://string-db.org/network/83332.Rv1066Rv1066, (MTV017.19), len: 131 aa. Conserved hypothetical protein, strong similarity to AL0209|SC4H8.10 hypothetical protein from Streptomyces coelicolor (132 aa),FASTA scores: opt: 429, E(): 5.2e [...]
PE_PGRS19 protein networkhttps://string-db.org/network/83332.Rv1067cPE-PGRS family protein PE_PGRS19; Rv1067c, (MTV017.20c), len: 667 aa. PE_PGRS19,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
PE_PGRS20 protein networkhttps://string-db.org/network/83332.Rv1068cPE-PGRS family protein PE_PGRS20; Rv1068c, (MTV017.21c), len: 463 aa. PE_PGRS20,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
Rv1069c protein networkhttps://string-db.org/network/83332.Rv1069cConserved protein; Rv1069c, (MTV017.22c), len: 587 aa. Conserved protein, hydrophobic regions in N-terminal domain. Similar in part to O07136|B1306.04C B1306.04c protein from Mycobacterium leprae [...]
echA8 protein networkhttps://string-db.org/network/83332.Rv1070cProbable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Could possibly oxidize fatty acids using specific components.
echA9 protein networkhttps://string-db.org/network/83332.Rv1071cPossible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1071c, (MTV017.24c), len: 345 aa. Possible echA9,enoyl-CoA hydratase, equivalent to Y13803|B1306 [...]
Rv1072 protein networkhttps://string-db.org/network/83332.Rv1072Rv1072, (MTV017.25), len: 278 aa. Probable conserved transmembrane protein, equivalent to O07139|B1306.07|Y13803 Protein B1306.07 from Mycobacterium leprae (220 aa), FASTA scores: opt:1032, E(): [...]
Rv1073 protein networkhttps://string-db.org/network/83332.Rv1073Rv1073, (MTV017.26), len: 283 aa. Conserved hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. Rv1482c|Z79701|MTCY277.03 Mycobacterium tuberculosis (339 aa), FASTA [...]
fadA3 protein networkhttps://string-db.org/network/83332.Rv1074cRv1074c, (MTV017.27c), len: 405 aa. Probable fadA3,beta-ketoacyl CoA thiolase, highly similar to many involved in beta-oxidation e.g. CAB89028.1|AL353870 beta-ketoadipyl-CoA thiolase from Strepto [...]
Rv1075c protein networkhttps://string-db.org/network/83332.Rv1075cConserved exported protein; Esterase that preferentially hydrolyzes short-chain fatty acids, particularly pNP-acetate (C2) and pNP-butyrate (C4). Has also weak activity with pNP-hexanoate (C6) an [...]
lipU protein networkhttps://string-db.org/network/83332.Rv1076Possible lipase LipU; Esterase that shows preference for short chain fatty acids. Contributes to the growth of M.tuberculosis during the nutritive stress. Elicits strong humoral response in both [...]
cbs protein networkhttps://string-db.org/network/83332.Rv1077Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450); Rv1077, (MTV017.30), len: 464 aa. Probable cbs (previously cysM2), cystathionine beta-synthase, [...]
pra protein networkhttps://string-db.org/network/83332.Rv1078Rv1078, (MTV017.31), len: 240 aa. Probable pra,Proline-rich antigen homolog, equivalent to X65546|MLPRAG_1 proline rich antigen from Mycobacterium leprae (249 aa),FASTA scores: opt: 1162, E(): 3. [...]
metB protein networkhttps://string-db.org/network/83332.Rv1079Cystathionine gamma-synthase MetB (CGS) (O-succinylhomoserine [thiol]-lyase); Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replaceme [...]
greA protein networkhttps://string-db.org/network/83332.Rv1080cProbable transcription elongation factor GreA (transcript cleavage factor GreA); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresti [...]
Rv1081c protein networkhttps://string-db.org/network/83332.Rv1081cRv1081c, (MTV017.34c), len: 144 aa. Probable conserved membrane protein, with hydrophobic stretch from aa 26 - 48, highly similar to NP_302548.1|NC_002677 conserved membrane protein from Mycobact [...]
mca protein networkhttps://string-db.org/network/83332.Rv1082Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase); A mycothiol (MSH, N-acetyl-cysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cystei [...]
Rv1083 protein networkhttps://string-db.org/network/83332.Rv1083Rv1083, (MTV017.36), len: 88 aa. Conserved hypothetical protein, similar to U15183|MLU15183_9 hypothetical protein from Mycobacterium leprae (167 aa),FASTA scores: opt: 332, E(): 1.2e-13, (58.4% [...]
Rv1084 protein networkhttps://string-db.org/network/83332.Rv1084Conserved protein; Rv1084, (MTV017.37), len: 673 aa. Conserved protein,similar to P37512|YYAL_BACSU hypothetical protein from Bacillus subtilis (689 aa), FASTA scores: opt: 1063, E() : 0, (36.5% [...]
Rv1085c protein networkhttps://string-db.org/network/83332.Rv1085cRv1085c, (MTV017.38c), len: 242 aa. Possible hemolysin-like protein, integral membrane protein, similar to many hemolysins, and hypothetical proteins e.g. U28375|ECU28375_49 Hypothetical protein [...]
Rv1086 protein networkhttps://string-db.org/network/83332.Rv1086(2Z,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of only one isopentenyl pyrophosphate (IPP) unit in the cis configuration to E-geranyl diphosphate (E-GPP) generating the 15 carb [...]
PE_PGRS21 protein networkhttps://string-db.org/network/83332.Rv1087PE-PGRS family protein PE_PGRS21; Rv1087, (MTV017.40), len: 767 aa. PE_PGRS21, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Simila [...]
Rv1087A protein networkhttps://string-db.org/network/83332.Rv1087ARv1087A, len: 106 aa (fragment). Conserved hypothetical protein, highly similar to C-terminus of near ORF O53434|YA86_MYCTU|Rv1086|MT1118|MTV017.39 short (C15) chain Z-isoprenyl diphosphate synth [...]
PE9 protein networkhttps://string-db.org/network/83332.Rv1088PE family protein PE9; Together with PE10, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF [...]
PE10 protein networkhttps://string-db.org/network/83332.Rv1089PE family protein PE10; Together with PE9, induces macrophage apoptosis through human Toll-like receptor 4 (TLR4) signaling pathway. Interaction with TLR4 leads to increased levels of phospho-IRF [...]
celA2a protein networkhttps://string-db.org/network/83332.Rv1089ARv1089A, len: 34 aa. Probable celA2a, first part of cellulase (endoglucanase), similar to N-terminus of others. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 [...]
celA2b protein networkhttps://string-db.org/network/83332.Rv1090Rv1090, (MTV017.43), len: 151 aa. Probable celA2b,second part of cellulase (endoglucanase), similar to C-terminus of others e.g. O08468 cellulase CEL2 from Streptomyces halstedi (377 aa), FASTA s [...]
PE_PGRS22 protein networkhttps://string-db.org/network/83332.Rv1091PE-PGRS family protein PE_PGRS22; Rv1091, (MTV017.44), len: 853 aa. PE_PGRS22, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Simila [...]
coaA protein networkhttps://string-db.org/network/83332.Rv1092cRv1092c, (MTV017.45c), len: 312 aa. Probable coaA,pantothenate kinase, similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores :opt: 1079, E(): 0,(52.7% identity in 311 aa [...]
glyA1 protein networkhttps://string-db.org/network/83332.Rv1093Serine hydroxymethyltransferase 1 GlyA1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the [...]
desA2 protein networkhttps://string-db.org/network/83332.Rv1094Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis.
phoH2 protein networkhttps://string-db.org/network/83332.Rv1095Rv1095, (MTV017.48), len: 433 aa. Probable phoH2,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein. Equivalent to AL049491 MLCB1222_14 Mycobacterium leprae (43 [...]
Rv1096 protein networkhttps://string-db.org/network/83332.Rv1096Rv1096, (MTV017.49), len: 291 aa. Possible glycosyl hydrolase, possibly deacetylase or esterase. Equivalent to AL049491|MLCB1222_13 Mycobacterium leprae (291 aa) (81.3% identity in 289 aa overlap [...]
Rv1097c protein networkhttps://string-db.org/network/83332.Rv1097cRv1097c, (MTV017.50c), len: 293 aa. Probable membrane Gly-, Pro-rich protein, similar to Mycobacterium tuberculosis Rv2507|MTCY07A7. 13|Z95556 (273 aa), FASTA scores: opt: 219, E(): 0.023, (30.5% [...]
fum protein networkhttps://string-db.org/network/83332.Rv1098cProbable fumarase Fum (fumarate hydratase); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fum [...]
glpX protein networkhttps://string-db.org/network/83332.Rv1099cFructose 1,6-bisphosphatase GlpX; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Seems to be the major FBPase of M.tuberculosis and to play a key role in gluconeog [...]
Rv1100 protein networkhttps://string-db.org/network/83332.Rv1100Conserved protein; Rv1100, (MTV017.53), len: 233 aa. Conserved protein,slightly similar to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: opt: 122 [...]
Rv1101c protein networkhttps://string-db.org/network/83332.Rv1101cConserved membrane protein; Rv1101c, (MTV017.54c), len: 385 aa. Conserved membrane protein, shows some similarity to other bacterial proteins e.g. P77406|PERM_ECOLI putative permease perm from Es [...]
mazF3 protein networkhttps://string-db.org/network/83332.Rv1102cToxin MazF3; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an mRNA and 23S rRNA interferase, cleaving predominantly after the first 2 Us in the sequence 5'-UUCCU-3'; in 23S rR [...]
mazE3 protein networkhttps://string-db.org/network/83332.Rv1103cPossible antitoxin MazE3; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF3. Overexpression of [...]
Rv1104 protein networkhttps://string-db.org/network/83332.Rv1104Rv1104, (MTV017.57), len: 229 aa. Possible para-nitrobenzyl esterase (fragment; possibly first part). Similar to the N-terminal domain of many e.g. P37967|PNBA_BACSU Bacillus subtilis (489 aa), F [...]
Rv1105 protein networkhttps://string-db.org/network/83332.Rv1105Rv1105, (MTV017.58), len: 171 aa. Possible para-nitrobenzyl esterase (fragment; possibly second part). Similar to C-terminal domain of many e.g. P71048 para-nitrobenzyl esterase from Bacillus sub [...]
Rv1106c protein networkhttps://string-db.org/network/83332.Rv1106c3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into chole [...]
xseB protein networkhttps://string-db.org/network/83332.Rv1107cProbable exodeoxyribonuclease VII (small subunit) XseB (exonuclease VII small subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then de [...]
xseA protein networkhttps://string-db.org/network/83332.Rv1108cProbable exodeoxyribonuclease VII (large subunit) XseA (exonuclease VII large subunit); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then de [...]
Rv1109c protein networkhttps://string-db.org/network/83332.Rv1109cConserved protein; Rv1109c, (MTV017.62c), len: 212 aa. Conserved protein. Equivalent to AL049491|MLCB1222_4 hypothetical protein from Mycobacterium leprae (205 aa) (68.1% identity in 213 aa overl [...]
lytB2 protein networkhttps://string-db.org/network/83332.Rv1110Probable LYTB-related protein LytB2; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphospha [...]
Rv1111c protein networkhttps://string-db.org/network/83332.Rv1111cRv1111c, (MTV017.64c), len: 327 aa. Conserved hypothetical protein, N-terminal domain is hydrophobic,C-terminal half is very rich in Arg. Equivalent to AL049491|MLCB1222_2 hypothetical protein fr [...]
ychF protein networkhttps://string-db.org/network/83332.Rv1112Probable GTP binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
vapB32 protein networkhttps://string-db.org/network/83332.Rv1113Possible antitoxin VapB32; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC32.
vapC32 protein networkhttps://string-db.org/network/83332.Rv1114Possible toxin VapC32. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv1115 protein networkhttps://string-db.org/network/83332.Rv1115Possible exported protein; Rv1115, (MTCY22G8.04), len: 232 aa. Possible exported protein, contains possible N-terminal signal sequence.
Rv1116 protein networkhttps://string-db.org/network/83332.Rv1116Hypothetical protein; Rv1116, (MTCY22G8.05), len: 61 aa. Hypothetical unknown protein.
Rv1116A protein networkhttps://string-db.org/network/83332.Rv1116ARv1116A, len: 91 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of Rv1646|Z85982_9 from Mycobacterium tuberculosis (310 aa),FASTA scores: opt: 301, E(): 9 [...]
Rv1117 protein networkhttps://string-db.org/network/83332.Rv1117Conserved protein; Rv1117, (MTCY22G8.06), len: 107 aa. Conserved protein, some similarity to P94425|D50453 hypothetical protein from Bacillus subtilis (95 aa), fasta scores: opt: 128, E(): 5.1e-0 [...]
Rv1118c protein networkhttps://string-db.org/network/83332.Rv1118cConserved protein; Rv1118c, (MTCY22G8.07c), len: 286 aa. Conserved protein, similar to pseudogene ML0942 in Mycobacterium leprae.
Rv1119c protein networkhttps://string-db.org/network/83332.Rv1119cHypothetical protein; Rv1119c, (MTCY22G8.08c), len: 49 aa. Hypothetical unknown protein.
Rv1120c protein networkhttps://string-db.org/network/83332.Rv1120cRv1120c, (MTCY22G8.09c), len: 164 aa. Conserved hypothetical protein, some similarity at C-terminus to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1890c|MTCY180.28 (462 aa), FASTA sco [...]
zwf1 protein networkhttps://string-db.org/network/83332.Rv1121Probable glucose-6-phosphate 1-dehydrogenase Zwf1 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
gnd2 protein networkhttps://string-db.org/network/83332.Rv1122Rv1122, (MTCY22G8.11), len: 340 aa. Probable gnd2,6-phosphogluconate dehydrogenase, decarboxylating, highly similar to Q53917 6-phosphogluconate dehydrogenase from Streptomyces coelicolor (291 aa [...]
bpoB protein networkhttps://string-db.org/network/83332.Rv1123cRv1123c, (MTCY22G8.12c), len: 302 aa. Possible bpoB,peroxidase (non-haem peroxidase), with some similarity to a range of enzymes from several organisms including: DEH1_MORSP|Q01398 haloacetate de [...]
ephC protein networkhttps://string-db.org/network/83332.Rv1124Rv1124, (MTCY22G8.13), len: 316 aa. Probable ephC,epoxide hydrolase (see citation below), similar to Q42566 epoxide hydrolase from Arabidopsis thaliana (321 aa), FASTA scores: opt: 298, E(): 8.2e [...]
Rv1125 protein networkhttps://string-db.org/network/83332.Rv1125Rv1125, (MTCY22G8.14), len: 414 aa. Conserved hypothetical protein. Similar to AL133278|SCM11.13 hypothetical protein from Streptomyces coelicolor (446 aa),FASTA scores: opt: 182, E(): 0.0005, (2 [...]
Rv1126c protein networkhttps://string-db.org/network/83332.Rv1126cConserved protein; Rv1126c, (MTCY22G8.15c), len: 201 aa. Conserved protein, similar in N-terminus to O05567|MLCB33.17 hypothetical protein from Mycobacterium leprae (141 aa),FASTA scores: opt: 33 [...]
ppdK protein networkhttps://string-db.org/network/83332.Rv1127cRv1127c, (MTCY22G8.16c), len: 490 aa. Probable ppdK,Pyruvate, phosphate dikinase. Equivalent (but shorter) to Z94723|MLCB33_16 ppdK from Mycobacterium leprae (601 aa) (71.8% identity in 478 aa ov [...]
Rv1128c protein networkhttps://string-db.org/network/83332.Rv1128cRv1128c, (MTCY22G8.17c), len: 451 aa. Conserved hypothetical protein, in REP13E12 degenerate repeat, highly similar to several Mycobacterium tuberculosis proteins in REP13E12 repeats e.g. Rv1148c [...]
prpR protein networkhttps://string-db.org/network/83332.Rv1129cProbable transcriptional regulator protein; Plays a key role in regulating expression of enzymes involved in the catabolism of short chain fatty acids (SCFA) via both the glyoxylate (acetyl degra [...]
prpD protein networkhttps://string-db.org/network/83332.Rv1130Possible methylcitrate dehydratase PrpD; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle [...]
prpC protein networkhttps://string-db.org/network/83332.Rv1131Probable methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I ( [...]
Rv1132 protein networkhttps://string-db.org/network/83332.Rv1132Conserved membrane protein; Rv1132, (MTCY22G8.21), len: 576 aa. Conserved membrane protein, similar to O06827|Rv1431|MTCY493.23C membrane protein from Mycobacterium tuberculosis (589 aa),fasta sc [...]
metE protein networkhttps://string-db.org/network/83332.Rv1133c5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; B [...]
Rv1135A protein networkhttps://string-db.org/network/83332.Rv1135ARv1135A, len: 80 aa. Possible acetyl-CoA acetyltransferase (possible gene fragment), highly similar to other acetyl-CoA acetyltransferases e.g. C-terminal part of Rv3556c|Z92774|MTCY6G11_2|MTCY06 [...]
PPE16 protein networkhttps://string-db.org/network/83332.Rv1135cRv1135c, (MTCI65.02c), len: 618 aa. PPE16, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to Rv2356c (59.6% identity in 627 aa overlap); etc.. Predicted to [...]
Rv1136 protein networkhttps://string-db.org/network/83332.Rv1136Possible enoyl-CoA hydratase; Rv1136, (MTCI65.03), len: 113 aa. Probable enoyl-CoA hydratase (possible gene fragment). Some similarity to N-terminus of carnitine racemases and enoyl-CoA hydratase [...]
Rv1137c protein networkhttps://string-db.org/network/83332.Rv1137cHypothetical protein; Rv1137c, (MTCI65.04c), len: 122 aa. Hypothetical unknown protein.
Rv1138c protein networkhttps://string-db.org/network/83332.Rv1138cRv1138c, (MTCI65.05c), len: 338 aa. Possible oxidoreductase, similar to Q9EWQ8 putative oxidoreductase from Streptomyces coelicolor (343 aa). Also similar to many Mycobacterium tuberculosis hypot [...]
Rv1139c protein networkhttps://string-db.org/network/83332.Rv1139cRv1139c, (MTCI65.06c), len: 166 aa. Conserved hypothetical membrane protein. Highly similar to P54158|YBPQ_BACSU hypothetical Bacillus subtilis protein,YBPQ (168 aa), FASTA scores: opt: 446, E(): [...]
Rv1140 protein networkhttps://string-db.org/network/83332.Rv1140Rv1140, (MTCI65.07), len: 282 aa. Probable integral membrane protein. Weak similarity in C-terminus to hypothetical Escherichia coli proteins YPRA and YPRB,possibly membrane-bound e.g. YPRA_ECOLI [...]
echA11 protein networkhttps://string-db.org/network/83332.Rv1141cProbable enoyl-CoA hydratase EchA11 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1141c, (MTCI65.08c), len: 268 aa. Probable echA11,enoyl-CoA hydratase, similar to others e.g. P [...]
echA10 protein networkhttps://string-db.org/network/83332.Rv1142cProbable enoyl-CoA hydratase EchA10 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1142c, (MTCI65.09c), len: 268 aa. Probable echA10,enoyl-CoA hydratase, similar to others e.g. C [...]
mcr protein networkhttps://string-db.org/network/83332.Rv1143Alpha-methylacyl-CoA racemase Mcr; Rv1143, (MTCI65.10), len: 360 aa. Probable mcr,alpha-methylacyl-CoA racemase. Strong similarity to other alpha-methylacyl-CoA racemases and also some similarity [...]
Rv1144 protein networkhttps://string-db.org/network/83332.Rv1144Rv1144, (MTCI65.11), len: 250 aa. Probable short-chain dehydrogenase/reductase, highly similar to various dehydrogenases e.g. NP_104056.1|NC_002678 3-hydroxyacyl-CoA dehydrogenase type II from Me [...]
mmpL13a protein networkhttps://string-db.org/network/83332.Rv1145Rv1145, (MTCI65.12), len: 303 aa. Probable mmpL13a,conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and [...]
mmpL13b protein networkhttps://string-db.org/network/83332.Rv1146Rv1146, (MTCI65.13), len: 470 aa. Probable mmpL13b,conserved transmembrane transport protein (see citation below), member of RND superfamily, showing some similarity to putative Mycobacterial and [...]
Rv1147 protein networkhttps://string-db.org/network/83332.Rv1147Conserved protein; Rv1147, (MTCI65.14), len: 216 aa. Conserved protein,similar to many conserved hypothetical proteins, and some similarity to several methyltransferases e.g. Q05197|PMTA_RHOSH ph [...]
Rv1148c protein networkhttps://string-db.org/network/83332.Rv1148cRv1148c, (MTCI65.15c), len: 482 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat, nearly identical to other hypothetical Mycobacterium tuberculosis proteins in REP13E12 repeats, altho [...]
Rv1149 protein networkhttps://string-db.org/network/83332.Rv1149Possible transposase; Rv1149, (MTCI65.16), len: 135 aa. Possible transposase. Identical to 117 aa N-terminal region of S21394|X65618 transposase of Mycobacterium tuberculosis (308 aa), FASTA scor [...]
Rv1150 protein networkhttps://string-db.org/network/83332.Rv1150Possible transposase (fragment); Rv1150, (MTCI65.17), len: 183 aa. Possible fragment of transposase (pseudogene). Identical to C-terminal part of S21394 transposase of putative Mycobacterium tube [...]
cobB-2 protein networkhttps://string-db.org/network/83332.Rv1151cTranscriptional regulatory protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several [...]
Rv1152 protein networkhttps://string-db.org/network/83332.Rv1152Rv1152, (MTCI65.19), len: 121 aa (Start uncertain). Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU hypothetical transcriptional regulator (121 aa), FASTA s [...]
omt protein networkhttps://string-db.org/network/83332.Rv1153cRv1153c, (MTCI65.20c), len: 282 aa. Probable omt,O-methyltransferase, similar to TCMP_STRGA|P39887 Tetracenomycin polyketide synthesis O-methyltransferase tcmP from Streptomyces glaucescens (270 [...]
Rv1154c protein networkhttps://string-db.org/network/83332.Rv1154cHypothetical protein; Rv1154c, (MTCI65.21c), len: 213 aa. Hypothetical unknown protein, start uncertain.
Rv1155 protein networkhttps://string-db.org/network/83332.Rv1155F420H(2)-dependent reductase Rv1155; F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is l [...]
Rv1156 protein networkhttps://string-db.org/network/83332.Rv1156Conserved protein; Rv1156, (MTCI65.23), len: 195 aa. Conserved protein,highly similar to CAC32318.1|AL583944 conserved hypothetical protein from Streptomyces coelicolor (197 aa).
Rv1157c protein networkhttps://string-db.org/network/83332.Rv1157cRv1157c, (MTCI65.24c), len: 371 aa. Conserved Ala-,Pro-rich protein, similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fi [...]
Rv1158c protein networkhttps://string-db.org/network/83332.Rv1158cRv1158c, (MTCI65.25c), len: 227 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: op [...]
pimE protein networkhttps://string-db.org/network/83332.Rv1159Mannosyltransferase PimE; Catalyzes the alpha-1,2 addition of a mannose residue from polyprenol-phosphate-mannose (PPM) to a monoacyl phosphatidylinositol pentamannoside (AcPIM5) to generate a mo [...]
Rv1159A protein networkhttps://string-db.org/network/83332.Rv1159ARv1159A, len: 94 aa. Unknown protein.
mutT2 protein networkhttps://string-db.org/network/83332.Rv1160Probable mutator protein MutT2 (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase); May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dih [...]
narG protein networkhttps://string-db.org/network/83332.Rv1161Respiratory nitrate reductase (alpha chain) NarG; The alpha chain is the actual site of nitrate reduction (Probable). Supports anaerobic growth of E.coli on glycerol in an E.coli mutant lacking e [...]
narH protein networkhttps://string-db.org/network/83332.Rv1162Rv1162, (MTCI65.29), len: 558 aa. Probable narH,respiratory nitrate reductase beta chain. Similar to others e.g. NARH_BACSU|P42176 nitrate reductase beta chain from Bacillus subtilis (487 aa), FA [...]
narJ protein networkhttps://string-db.org/network/83332.Rv1163Rv1163, (MTCI65.30), len: 201 aa. Probable narJ,respiratory nitrate reductase delta chain. Similar to others e.g. P42178|NARJ_BACSU nitrate reductase delta chain from Bacillus subtilis (184 aa), [...]
narI protein networkhttps://string-db.org/network/83332.Rv1164Rv1164, (MTCI65.31), len: 246 aa. Probable narI,respiratory nitrate reductase gamma chain. Similar to others e.g. NARI_BACSU|P42177 nitrate reductase gamma chain from Bacillus subtilis (223 aa), [...]
typA protein networkhttps://string-db.org/network/83332.Rv1165GTP-binding protein TypA/BipA; Rv1165, (MTV005.01-MTCI65.32), len: 628 aa. Possible typA (alternate gene name: bipA), GTP-binding translation elongation factor, similar to several e.g. P32132|TYP [...]
lpqW protein networkhttps://string-db.org/network/83332.Rv1166Probable conserved lipoprotein LpqW; May directly or indirectly regulate the accessibility of the key branch point intermediate, monoacyl phosphatidylinositol tetramannoside (AcPIM4), to the elon [...]
Rv1167c protein networkhttps://string-db.org/network/83332.Rv1167cRv1167c, (MTV005.03c), len: 201 aa. Probable transcriptional regulator, similar to several e.g. D1022772|D85417 hemR from Propionibacterium freudenreichii (243 aa), FASTA scores: opt: 268, E(): 5 [...]
PPE17 protein networkhttps://string-db.org/network/83332.Rv1168cRv1168c, (MTV005.04c), len: 346 aa. PPE17, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. E332789|Z98268|MTCI125.27C (385 aa), FASTA scores: op [...]
lipX protein networkhttps://string-db.org/network/83332.Rv1169cPE family protein. Possible lipase LipX; Rv1169c, (MTV005.05c), len: 100 aa. Possible lipX,lipase. Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan & Delogu 2002), e.g. [...]
mshB protein networkhttps://string-db.org/network/83332.Rv11701D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol [...]
Rv1171 protein networkhttps://string-db.org/network/83332.Rv1171Rv1171, (MTV005.07), len: 146 aa. Conserved hypothetical protein, possibly transmembrane protein. Start has been changed since first submission.
PE12 protein networkhttps://string-db.org/network/83332.Rv1172cRv1172c, (MTV005.08c), len: 308 aa. PE12, Member of the Mycobacterium tuberculosis PE family of proteins (see Brennan & Delogu 2002), e.g. P71748|Z81368|MTCY253.25C (361 aa), FASTA scores: opt: 4 [...]
fbiC protein networkhttps://string-db.org/network/83332.Rv1173Probable F420 biosynthesis protein FbiC; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the [...]
TB8.4 protein networkhttps://string-db.org/network/83332.Rv1174cRv1174c, (MTV005.10c), len: 110 aa. TB8.4, low molecular weight T-cell antigen (see citations below),hypothetical unknown secreted protein. Predicted to be an outer membrane protein (See Song et [...]
fadH protein networkhttps://string-db.org/network/83332.Rv1175cRv1175c, (MTV005.11c), len: 674 aa. Probable fadH,NADPH-dependent 2,4-dienoyl-CoA reductase, highly similar to others e.g. NP_251782.1|NC_002516 2,4-dienoyl-CoA reductase FadH1 from Pseudomonas a [...]
Rv1176c protein networkhttps://string-db.org/network/83332.Rv1176cRv1176c, (MTV005.12c), len: 189 aa. Conserved hypothetical protein, some similarity to P94443|D78508 hypothetical protein from Bacillus subtilis (182 aa), FASTA scores: opt: 219, E(): 1.7e-15, (2 [...]
fdxC protein networkhttps://string-db.org/network/83332.Rv1177Probable ferredoxin FdxC; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Rv1178 protein networkhttps://string-db.org/network/83332.Rv1178Rv1178, (MTV005.14), len: 362 aa. Probable aminotransferase, weak similarity to many aspartate aminotransferases e.g. Q55679|D64000 SLL0006 aspartate aminotransferase from Synechocystis sp. (394 [...]
Rv1179c protein networkhttps://string-db.org/network/83332.Rv1179cUnknown protein; Rv1179c, MTV005.15c, len: 939 aa. Unknown protein.
pks3 protein networkhttps://string-db.org/network/83332.Rv1180Rv1180, (MTV005.16), len: 488 aa. Probable polyketide beta-ketoacyl synthase, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and similar to the N- [...]
pks4 protein networkhttps://string-db.org/network/83332.Rv1181Probable polyketide beta-ketoacyl synthase Pks4; Polyketide synthase involved in the biosynthesis of methyl- branched fatty acids such as mycolipanoic, mycolipenic (phthienoic) and mycolipodienoi [...]
papA3 protein networkhttps://string-db.org/network/83332.Rv1182Probable conserved polyketide synthase associated protein PapA3; Involved in the biosynthesis of polyacyltrehalose (PAT) which could have a role in anchoring the bacterial capsule. In vitro catal [...]
mmpL10 protein networkhttps://string-db.org/network/83332.Rv1183Probable conserved transmembrane transport protein MmpL10; Required for the biosynthesis of polyacyltrehalose (PAT) and the transport of diacyltrehalose (DAT) and possibly PAT to the cell surface [...]
chp2 protein networkhttps://string-db.org/network/83332.Rv1184cPossible exported protein; Involved in the final steps of polyacyltrehalose (PAT) biosynthesis. Catalyzes the transfer of three mycolipenoyl groups onto diacyltrehalose (DAT) to form PAT.
fadD21 protein networkhttps://string-db.org/network/83332.Rv1185cProbable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1185c, (MTV005.21c), len: 578 aa. Probable fadD21,fatty-acid-AMP synthetase, highly similar to sever [...]
Rv1186c protein networkhttps://string-db.org/network/83332.Rv1186cConserved protein; Rv1186c, (MTV005.22c), len: 538 aa. Conserved protein, similar to AL117385|SC5G9.24 hypothetical protein from Streptomyces coelicolor (555 aa), FASTA scores: opt: 485, E(): 2.3 [...]
rocA protein networkhttps://string-db.org/network/83332.Rv1187Rv1187, (MTV005.23), len: 543 aa. Probable rocA,pyrroline-5-carboxylate dehydrogenase, similar to many e.g. PUT2_HUMAN|P30038 human delta-1-pyrroline-5-carboxylate dehydrogenase (563 aa), FASTA s [...]
Rv1188 protein networkhttps://string-db.org/network/83332.Rv1188Probable proline dehydrogenase; Rv1188, (MTV005.24), len: 329 aa. Possible putA,proline dehydrogenase, similar to part of Q52711|X78346 proline dehydrogenase from Rhodobacter capsulatus (1127 aa) [...]
sigI protein networkhttps://string-db.org/network/83332.Rv1189Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extra [...]
Rv1190 protein networkhttps://string-db.org/network/83332.Rv1190Rv1190, (MTCI364.02), len: 292 aa. Conserved hypothetical protein, similar to Rv1833c|Y0DA_MYCTU|Q50600 hypothetical 32.2 kDa protein cy1a11.10 (286 aa), fasta scores: opt: 331, E(): 1.4e-15, (29 [...]
Rv1191 protein networkhttps://string-db.org/network/83332.Rv1191Conserved protein; Rv1191, (MTCI364.03), len: 304 aa. Conserved protein, similar to Q54528 RDMC from Streptomyces purpurascens (298 aa), FASTA scores: opt: 196, E(): 1.5e-05, (27.5% identity in 2 [...]
Rv1192 protein networkhttps://string-db.org/network/83332.Rv1192Unknown protein; Rv1192, (MTCI364.04), len: 275 aa. Unknown protein,contains PS00120 lipases, serine active site.
fadD36 protein networkhttps://string-db.org/network/83332.Rv1193Rv1193, (MTCI364.05), len: 473 aa. Probable fadD36,fatty-acid-CoA synthetase, highly similar to Q50017|U15181 4-coumarate-CoA ligase from Mycobacterium leprae (476 aa),FASTA scores: opt: 2594, E( [...]
Rv1194c protein networkhttps://string-db.org/network/83332.Rv1194cConserved protein; Rv1194c, (MTCI364.06c), len: 421 aa. Conserved protein, highly similar to Q50018 possible transcriptional activator from Mycobacterium leprae (517 aa), FASTA scores: opt: 1960, [...]
PE13 protein networkhttps://string-db.org/network/83332.Rv1195PE family protein PE13; May play a pivotal role in the interaction between M.tuberculosis and host. Can enhance the survival within macrophages under stress conditions such as H(2)O(2), SDS and l [...]
PPE18 protein networkhttps://string-db.org/network/83332.Rv1196PPE family protein PPE18; Could be a crucial virulence factor for intracellular survival of M.tuberculosis. Favors development of Th2-type response, and downregulates the proinflammatory and Th1- [...]
esxK protein networkhttps://string-db.org/network/83332.Rv1197Rv1197, (MT1235, MTCI364.09), len: 98 aa. EsxK,ESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1038c, etc. Almost identical to MTCY98. [...]
esxL protein networkhttps://string-db.org/network/83332.Rv1198Putative ESAT-6 like protein EsxL (ESAT-6 like protein 4); Induces apoptosis of host cells. Is immunogenic with highly specific seroreactivity towards TB patients' serum ; Belongs to the WXG100 f [...]
Rv1199c protein networkhttps://string-db.org/network/83332.Rv1199cPossible transposase; Required for the transposition of the insertion element.
Rv1200 protein networkhttps://string-db.org/network/83332.Rv1200Rv1200, (MTCI364.12), len: 425 aa. Probable conserved integral membrane transport protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. YHJE_ECOLI|P37643 hypothe [...]
dapD protein networkhttps://string-db.org/network/83332.Rv1201cTetrahydrodipicolinate N-succinyltransferase DapD; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
dapE protein networkhttps://string-db.org/network/83332.Rv1202Probable succinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermedia [...]
Rv1203c protein networkhttps://string-db.org/network/83332.Rv1203cHypothetical protein; Rv1203c, (MTCI364.15c), len: 194 aa. Hypothetical unknown protein.
Rv1204c protein networkhttps://string-db.org/network/83332.Rv1204cRv1204c, (MTCI364.16c), len: 562 aa. Conserved hypothetical protein, some similarity to Q55103 CHO-ORF2 from streptomyces SP. (642 aa), FASTA scores: opt: 215,E(): 3.6e-06, (26.4% identity in 576 [...]
log protein networkhttps://string-db.org/network/83332.Rv1205Conserved hypothetical protein; Catalyzes the hydrolytic removal of ribose 5'-monophosphate from nitrogen N6-modified adenosines, the final step of bioactive cytokinin synthesis. Is involved in t [...]
fadD6 protein networkhttps://string-db.org/network/83332.Rv1206Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1206, (MTCI364.18), len: 597 aa. Probable fadD6,fatty-acid-CoA synthetase, highly similar to several [...]
folP2 protein networkhttps://string-db.org/network/83332.Rv1207Dihydropteroate synthase 2 FolP2 (DHPS 2) (dihydropteroate pyrophosphorylase 2); Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the in [...]
gpgS protein networkhttps://string-db.org/network/83332.Rv1208Probable glucosyl-3-phosphoglycerate synthase GpgS; Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs). Catalyzes the transfer of a glucose (Glc) moiety from uridine dip [...]
Rv1209 protein networkhttps://string-db.org/network/83332.Rv1209Conserved protein; Rv1209, (MTCI364.21), len: 122 aa. Conserved protein, containing a hydrophobic N-terminus. Similar to Q49956|U1756M hypothetical protein from Mycobacterium leprae (114 aa), FAS [...]
tagA protein networkhttps://string-db.org/network/83332.Rv1210Rv1210, (MTCI364.22), len: 204 aa. Probable tagA,DNA-3-methyladenine glycosidase I (see citation below),similar to several e.g. 3MG1_ECOLI|P05100 DNA-3-methyladenine glycosidase I from Escherichi [...]
Rv1211 protein networkhttps://string-db.org/network/83332.Rv1211Conserved protein; Rv1211, (MTCI364.23), len: 75 aa. Conserved protein,similar to Q49958|U1756N Mycobacterium leprae (75 aa),FASTA scores: opt: 460, E(): 0, (90.7% identity in 75 aa overlap).
glgA protein networkhttps://string-db.org/network/83332.Rv1212cPutative glycosyl transferase GlgA; Involved in the biosynthesis of the maltose-1-phosphate (M1P) building block required for alpha-glucan production by the key enzyme GlgE. Catalyzes the formati [...]
glgC protein networkhttps://string-db.org/network/83332.Rv1213Glucose-1-phosphate adenylyltransferase GlgC (ADP-glucose synthase) (ADP-glucose pyrophosphorylase); Involved in the biosynthesis of ADP-glucose building block required in the biosynthesis of mal [...]
PE14 protein networkhttps://string-db.org/network/83332.Rv1214cRv1214c, (MTCI364.26c), len: 110 aa. PE14, Member of Mycobacterium tuberculosis PE family (see citation below),appears to be frameshifted but sequence appears to be correct. The 5'-end is atypica [...]
Rv1215c protein networkhttps://string-db.org/network/83332.Rv1215cConserved protein; Rv1215c, (MTCI364.27c), len: 561 aa. Conserved protein, low similarity to Rv1835c|Y0D8_MYCTU|Q50598 hypothetical 69.9 kDa protein cy1a11.08 (628 aa), FASTA scores: opt: 257, E( [...]
Rv1216c protein networkhttps://string-db.org/network/83332.Rv1216cRv1216c, (MTCI364.28c), len: 224 aa. Probable conserved integral membrane protein, C-terminal region similar to Q49963|U1756P from Mycobacterium leprae (134 aa), FASTA scores: opt: 311, E(): 3.3e [...]
Rv1217c protein networkhttps://string-db.org/network/83332.Rv1217cProbable tetronasin-transport integral membrane protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally un [...]
Rv1218c protein networkhttps://string-db.org/network/83332.Rv1218cProbable tetronasin-transport ATP-binding protein ABC transporter; Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelate [...]
raaS protein networkhttps://string-db.org/network/83332.Rv1219cProbable transcriptional regulatory protein; Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and ups [...]
Rv1220c protein networkhttps://string-db.org/network/83332.Rv1220cProbable methyltransferase; Rv1220c, (MTCI61.03c), len: 215 aa. Possible methyltransferase, some similarity to MDMC_STRMY|Q00719 o-methyltransferase from Streptomyces mycarofaciens (221 aa), FAST [...]
sigE protein networkhttps://string-db.org/network/83332.Rv1221Alternative RNA polymerase sigma factor SigE; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasm [...]
rseA protein networkhttps://string-db.org/network/83332.Rv1222Anti-sigma factor RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigE. ECF sigma factors are held in an inactive form by an anti-sigma factor; Belongs to the zinc-ass [...]
htrA protein networkhttps://string-db.org/network/83332.Rv1223Rv1223, (MTCI61.06), len: 528 aa. Probable htrA (alternate gene name: degP), serine protease precursor (see citations below), equivalent to U15180|MLU15180_31|Q49972|ML1078|HTRA possible serine p [...]
tatB protein networkhttps://string-db.org/network/83332.Rv1224Probable protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across m [...]
Rv1225c protein networkhttps://string-db.org/network/83332.Rv1225cRv1225c, (MTCI61.08c), len: 276 aa. Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. AE001078|AE001078_2 Archaeoglobus fulgidus (265 aa), FASTA scores: opt: 339 [...]
Rv1226c protein networkhttps://string-db.org/network/83332.Rv1226cRv1226c, (MTCI61.09c), len: 487 aa. Probable transmembrane protein. Some similarity to AL049841|SCE9.01 Streptomyces coelicolor (436 aa), FASTA scores: opt: 203,E(): 1.2e-05, (29.8% identity in 3 [...]
Rv1227c protein networkhttps://string-db.org/network/83332.Rv1227cProbable transmembrane protein; Rv1227c, (MTCI61.10c), len: 177 aa. Possible transmembrane protein, similar to P96615 hypothetical protein ydbS from Bacillus subtilis (159 aa), fasta scores: E(): [...]
lpqX protein networkhttps://string-db.org/network/83332.Rv1228Probable lipoprotein LpqX; Rv1228, (MTCI61.11), len: 185 aa. Probable lipoprotein LpqX. Contains possible signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lip [...]
mrp protein networkhttps://string-db.org/network/83332.Rv1229cProbable Mrp-related protein Mrp; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; In the C-terminal section; belongs to the Mrp/NBP35 ATP- binding protei [...]
Rv1230c protein networkhttps://string-db.org/network/83332.Rv1230cPossible membrane protein; Rv1230c, (MTV006.02c), len: 411 aa. Possible membrane protein with two hydrophobic stretches near N-terminus. Some similarity to Rv1022|MTCY10G2.27c|Z92539 probable lpq [...]
Rv1231c protein networkhttps://string-db.org/network/83332.Rv1231cProbable membrane protein; Rv1231c, (MTV006.03c), len: 180 aa. Probable membrane protein, similar to others e.g. AL390975 Streptomyces coelicolor (198 aa).
Rv1232c protein networkhttps://string-db.org/network/83332.Rv1232cConserved protein; Rv1232c, (MTV006.04c), len: 435 aa. Conserved protein, similar to other hypothetical proteins e.g. AB013374|AB013374_2 Bacillus halodurans C-125 mamX (449 aa), FASTA scores: op [...]
Rv1233c protein networkhttps://string-db.org/network/83332.Rv1233cRv1233c, (MTV006.05c), len: 198 aa. Conserved hypothetical membrane protein, N-terminus is highly proline rich, C-terminus has two hydrophobic stretches. Proline-rich N-terminus has some similari [...]
Rv1234 protein networkhttps://string-db.org/network/83332.Rv1234Probable transmembrane protein; Rv1234, (MTV006.06), len: 175 aa. Possible transmembrane protein with two TM helices.
lpqY protein networkhttps://string-db.org/network/83332.Rv1235Probable sugar-binding lipoprotein LpqY; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recycling of extracellular treh [...]
sugA protein networkhttps://string-db.org/network/83332.Rv1236Probable sugar-transport integral membrane protein ABC transporter SugA; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the [...]
sugB protein networkhttps://string-db.org/network/83332.Rv1237Probable sugar-transport integral membrane protein ABC transporter SugB; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the [...]
sugC protein networkhttps://string-db.org/network/83332.Rv1238Probable sugar-transport ATP-binding protein ABC transporter SugC; Part of the ABC transporter complex LpqY-SugA-SugB-SugC, which is highly specific for uptake of trehalose. Involved in the recyc [...]
corA protein networkhttps://string-db.org/network/83332.Rv1239cPossible magnesium and cobalt transport transmembrane protein CorA; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
mdh protein networkhttps://string-db.org/network/83332.Rv1240Probable malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
vapB33 protein networkhttps://string-db.org/network/83332.Rv1241Possible antitoxin VapB33; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC33.
vapC33 protein networkhttps://string-db.org/network/83332.Rv1242Possible toxin VapC33. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
PE_PGRS23 protein networkhttps://string-db.org/network/83332.Rv1243cPE-PGRS family protein PE_PGRS23; Rv1243c, (MTV006.15c), len: 562 aa. PE_PGRS23,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
lpqZ protein networkhttps://string-db.org/network/83332.Rv1244Probable lipoprotein LpqZ; Rv1244, (MTV006.16), len: 286 aa. Probable lipoprotein lpqZ, equivalent toU15180|MLU1518042 protein u1756x from Mycobacterium leprae (228 aa), FASTA scores: opt: 1039, [...]
Rv1245c protein networkhttps://string-db.org/network/83332.Rv1245cRv1245c, (MTV006.17c), len: 276 aa. Probable short-chain dehydrogenase/reductase, equivalent to NP_301801.1|NC_002677 short chain alcohol dehydrogenase from Mycobacterium leprae (277 aa). Also hi [...]
relE protein networkhttps://string-db.org/network/83332.Rv1246cToxin RelE; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriost [...]
relB protein networkhttps://string-db.org/network/83332.Rv1247cAntitoxin RelB; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of toxin RelE.
kgd protein networkhttps://string-db.org/network/83332.Rv1248cMultifunctional alpha-ketoglutarate metabolic enzyme; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leadi [...]
Rv1249c protein networkhttps://string-db.org/network/83332.Rv1249cPossible membrane protein; Rv1249c, (MTV006.21c), len: 262 aa. Possible membrane protein. Start uncertain. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 200 [...]
Rv1250 protein networkhttps://string-db.org/network/83332.Rv1250Rv1250, (MTV006.22), len: 579 aa. Probable drug-transport integral membrane protein, member of major facilitator superfamily (MFS), highly similar to several including P39886|TCMA_STRGA tetraceno [...]
Rv1251c protein networkhttps://string-db.org/network/83332.Rv1251cRv1251c, (MTV006.23c), len: 1139 aa. Conserved hypothetical protein, showing some similarity in C-terminal region with other proteins from eukaryotes and bacteria e.g. NP_142121.1 hypothetical pr [...]
lprE protein networkhttps://string-db.org/network/83332.Rv1252cProbable lipoprotein LprE; Rv1252c, (MTCY50.30), len: 202 aa. Probable lipoprotein lprE, some similarity to Mycobacterium tuberculosis protein Rv3483c|MTCY13E12.36C (220 aa), FASTA scores: E(): 7 [...]
deaD protein networkhttps://string-db.org/network/83332.Rv1253Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog); DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome [...]
Rv1254 protein networkhttps://string-db.org/network/83332.Rv1254Rv1254, (MTCY50.28c), len: 383 aa. Probable Acyltransferase, similar to G927228 midecamycin 4-0-propionyl transferase (fragment) (388 aa), FASTA scores, opt: 305, E(): 5.6e-14, (28.4% identity in [...]
Rv1255c protein networkhttps://string-db.org/network/83332.Rv1255cRv1255c, (MTCY50.27), len: 202 aa. Possible regulatory protein, similar to others e.g. ACRR_ECOLI|P34000 potential acrab operon repressor from E. coli (215 aa), FASTA scores: opt: 128, E(): 0.25, [...]
cyp130 protein networkhttps://string-db.org/network/83332.Rv1256cRv1256c, (MT1295, MTCY50.26), len: 405 aa. Probable cyp130, cytochrome P450, similar to other cytochromes P-450 e.g. S51594 cytochrome P450 mycG from Micromonospora griseorubida (397 aa); T36526 [...]
Rv1257c protein networkhttps://string-db.org/network/83332.Rv1257cRv1257c, (MTCY50.25), len: 455 aa. Probable oxidoreductase, similar to e.g. GLCD_ECOLI|P52075 glycolate oxidase subunit glcd (499 aa), FASTA scores: E(): 0, (38.9% identity in 458 aa overlap). Si [...]
tap protein networkhttps://string-db.org/network/83332.Rv1258cProbable conserved integral membrane transport protein; Efflux pump that contributes to intrinsic antibiotic resistance. The pump uses the electrochemical gradient as a source of energy (By simil [...]
udgB protein networkhttps://string-db.org/network/83332.Rv1259Probable uracil DNA glycosylase, UdgB; DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair. Can also ex [...]
Rv1260 protein networkhttps://string-db.org/network/83332.Rv1260Rv1260, (MTCY50.22c), len: 372 aa. Probable oxidoreductase, highly similar to E1245747|AL021411 putative oxidoreductase SC7H1.18 from Streptomyces coelicolor (397 aa), FASTA scores: E(): 1.4e-29, [...]
Rv1261c protein networkhttps://string-db.org/network/83332.Rv1261cConserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron [...]
Rv1262c protein networkhttps://string-db.org/network/83332.Rv1262cRv1262c, (MTCY50.20), len: 144 aa. Hypothetical hit-like protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % identity in 142 aa overlap [...]
amiB2 protein networkhttps://string-db.org/network/83332.Rv1263Rv1263, (MTCY50.19c), len: 462 aa. Probable amiB2,amidase. Similar to G1001278 hypothetical 54.3 kDa protein (506 aa), FASTA scores: opt: 767, E(): 7.6e-40, (32.8% identity in 461 aa overlap), al [...]
Rv1264 protein networkhttps://string-db.org/network/83332.Rv1264Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Catalyzes the formation of the second messenger cAMP; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Rv1265 protein networkhttps://string-db.org/network/83332.Rv1265Unknown protein; Rv1265, (MTCY50.17c), len: 226 aa. Unknown protein (see citation below).
pknH protein networkhttps://string-db.org/network/83332.Rv1266cProbable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H); May regulate bacterial growth in response to external signals to facilitate adaptation to the host envir [...]
embR protein networkhttps://string-db.org/network/83332.Rv1267cProbable transcriptional regulatory protein EmbR; Positively regulates the transcription of the embCAB operon. Exhibits ATPase and GTPase activities; Belongs to the AfsR/DnrI/RedD regulatory fami [...]
Rv1268c protein networkhttps://string-db.org/network/83332.Rv1268cHypothetical protein; Rv1268c, (MTCY50.14), len: 232 aa. Hypothetical unknown protein, probably secreted protein : contains possible signal peptide sequence (score 7.9 at residue 28). Predicted t [...]
Rv1269c protein networkhttps://string-db.org/network/83332.Rv1269cRv1269c, (MTCY50.13), len: 124 aa. Conserved probable exported protein with putative N-terminal signal sequence. Similar to Mycobacterium tuberculosis protein Rv1813c|Y0DU_MYCTU|Q50620 hypothetic [...]
lprA protein networkhttps://string-db.org/network/83332.Rv1270cPossible lipoprotein LprA; Constitutes a host TLR2 agonist (toll-like receptor), shown experimentally for human and mouse. In host cells full-length (acylated) protein acts as a TLR2 agonist, ind [...]
Rv1271c protein networkhttps://string-db.org/network/83332.Rv1271cRv1271c, (MTCY50.11), len: 113 aa. Conserved hypothetical exported protein with potential N-terminal signal sequence. Similar to Mycobacterium tuberculosis hypothetical proteins Rv1804c, Rv1810, [...]
Rv1272c protein networkhttps://string-db.org/network/83332.Rv1272cProbable drugs-transport transmembrane ATP-binding protein ABC transporter; ABC transporter involved in fatty acid import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-bind [...]
Rv1273c protein networkhttps://string-db.org/network/83332.Rv1273cRv1273c, (MTCY50.09), len: 582 aa. Probable drugs-transport transmembrane ATP-binding protein ABC transporter (see citation below), similar to e.g. YWJA_BACSU|P45861 hypothetical abc transporter [...]
lprB protein networkhttps://string-db.org/network/83332.Rv1274Rv1274, (MTCY50.08c), len: 185 aa. Possible lprB,lipoprotein; contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). So [...]
lprC protein networkhttps://string-db.org/network/83332.Rv1275Rv1275, (MTCY50.07c), len: 180 aa. Possible lprC,lipoprotein; contains possible N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013). So [...]
Rv1276c protein networkhttps://string-db.org/network/83332.Rv1276cRv1276c, (MTCY50.06), len: 158 aa. Conserved hypothetical protein, similar to AL096844|SCI28.03 hypothetical protein from Streptomyces coelicolor (172 aa),FASTA scores: opt: 385, E(): 3.3e-19, (4 [...]
Rv1277 protein networkhttps://string-db.org/network/83332.Rv1277Rv1277, (MTCY50.05c), len: 417 aa. Conserved hypothetical protein, some similarity to 3914967|O68033|SBCD_RHOCA exonuclease SBCD homolog from Rhodobacter capsulatus (405 aa). May be sbcD protein [...]
Rv1278 protein networkhttps://string-db.org/network/83332.Rv1278Hypothetical protein; Rv1278, (MTCY50.04c), len: 875 aa. Hypothetical unknown protein, possible coiled-coil regions, contains PS00017 ATP/GTP-binding site motif A. A core mycobacterial gene; cons [...]
Rv1279 protein networkhttps://string-db.org/network/83332.Rv1279Rv1279, (MTCY50.03c), len: 528 aa. Probable dehydrogenase, FAD flavoprotein GMC oxidoreductase, similar to several e.g. dBETA_ECOLI|P17444 choline dehydrogenase from Escherichia coli (556 aa), FA [...]
oppA protein networkhttps://string-db.org/network/83332.Rv1280cRv1280c, (MTCY50.02), len: 591 aa. Probable oppA,oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute b [...]
oppD protein networkhttps://string-db.org/network/83332.Rv1281cRv1281c, (MTCY50.01), len: 612 aa. Probable oppD,oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP- [...]
oppC protein networkhttps://string-db.org/network/83332.Rv1282cRv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa. Probable oppC, oligopeptide-transport integral membrane protein ABC transporter (see Braibant et al., 2000),similar to other integral membrane prot [...]
oppB protein networkhttps://string-db.org/network/83332.Rv1283cRv1283c, (MTCY373.02c), len: 325 aa. Probable oppB,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. DPPB_ECO [...]
canA protein networkhttps://string-db.org/network/83332.Rv1284Beta-carbonic anhydrase; Catalyzes the reversible hydration of carbon dioxide to form bicarbonate; Belongs to the beta-class carbonic anhydrase family.
cysD protein networkhttps://string-db.org/network/83332.Rv1285Rv1285, (MTCY373.04), len: 332 aa. Probable cysD,sulfate adenylyltransferase subunit 2 (see Wooff et al.,2002), homology suggests start site at aa 24 or 28, similar to e.g. CYSD_ECOLI|P21156 sulf [...]
cysN protein networkhttps://string-db.org/network/83332.Rv1286Sulfate adenylyltransferase subunit 1; ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity; In the C-terminal section; belongs to the APS kinase family.
Rv1287 protein networkhttps://string-db.org/network/83332.Rv1287Rv1287, (MTCY373.06), len: 161 aa. Conserved hypothetical protein, similar to VjeB family of proteins e.g. FASTA score: P44675|Y379_HAEIN hypothetical protein HI0379 (150 aa), FASTA scores: opt: [...]
Rv1288 protein networkhttps://string-db.org/network/83332.Rv1288Conserved protein; Exhibits lipolytic activity with medium chain length esters as optimum substrates. In vitro, pNP-caprylate (C8) is the optimum substrate followed by pNP-capricate (C10). May mo [...]
Rv1289 protein networkhttps://string-db.org/network/83332.Rv1289Unknown protein; Rv1289, (MTCY373.08), len: 210 aa. Unknown protein.
Rv1290A protein networkhttps://string-db.org/network/83332.Rv1290ARv1290A, len: 104 aa. Hypothetical unknown protein,equivalent to AAK45590 from Mycobacterium tuberculosis strain CDC1551 (122 aa) but shorter 18 aa.
Rv1290c protein networkhttps://string-db.org/network/83332.Rv1290cConserved protein; Rv1290c, (MTCY373.09c), len: 521 aa. Conserved protein (see citation below), similar to AL031013|SC8A6.09 hypothetical protein from Streptomyces coelicolor (443 aa),FASTA score [...]
Rv1291c protein networkhttps://string-db.org/network/83332.Rv1291cRv1291c, (MTCY373.10c), len: 111 aa. Conserved hypothetical secreted protein, similar to others in Mycobacterium tuberculosis e.g. Rv1271c|Q11048|YC71_MYCTU hypothetical 11.6 kDa protein (113 aa) [...]
argS protein networkhttps://string-db.org/network/83332.Rv1292Rv1292, (MTCY373.12), len: 550 aa. Probable argS,Arginyl-tRNA synthetase, highly similar to SYR_MYCLE|P45840 Mycobacterium leprae (550 aa), FASTA scores: opt: 3115,E(): 0, (84.9% identity in 550 [...]
lysA protein networkhttps://string-db.org/network/83332.Rv1293Diaminopimelate decarboxylase LysA (DAP decarboxylase); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M. [...]
thrA protein networkhttps://string-db.org/network/83332.Rv1294Rv1294, (MTCY373.14), len: 441 aa. Probable thrA (hom), homoserine dehydrogenase, highly similar to DHOM_MYCLE|P46806 from Mycobacterium leprae (441 aa), FASTA scores: opt: 2437, E():0, (89.5% id [...]
thrC protein networkhttps://string-db.org/network/83332.Rv1295Threonine synthase ThrC (ts); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
thrB protein networkhttps://string-db.org/network/83332.Rv1296Probable homoserine kinase ThrB; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
rho protein networkhttps://string-db.org/network/83332.Rv1297Probable transcription termination factor Rho homolog; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase [...]
rpmE protein networkhttps://string-db.org/network/83332.Rv129850S ribosomal protein L31 RpmE; Binds the 23S rRNA.
prfA protein networkhttps://string-db.org/network/83332.Rv1299Probable peptide chain release factor 1 PrfA (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
hemK protein networkhttps://string-db.org/network/83332.Rv1300Probable HemK protein homolog HemK; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Rv1301 protein networkhttps://string-db.org/network/83332.Rv1301Conserved protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-th [...]
rfe protein networkhttps://string-db.org/network/83332.Rv1302Decaprenyl-phosphate N-acetylglucosaminephosphotransferase; Involved in the biosynthesis of the disaccharide D-N- acetylglucosamine-L-rhamnose which plays an important role in the mycobacterial c [...]
Rv1303 protein networkhttps://string-db.org/network/83332.Rv1303Rv1303, (MTCY373.23), len: 161 aa. Conserved hypothetical transmembrane protein, highly similar to P53431|Y02N_MYCLE hypothetical Mycobacterium leprae protein (153 aa), FASTA score: opt: 636, E() [...]
atpB protein networkhttps://string-db.org/network/83332.Rv1304Probable ATP synthase a chain AtpB (protein 6); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain fami [...]
atpE protein networkhttps://string-db.org/network/83332.Rv1305ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramemb [...]
atpF protein networkhttps://string-db.org/network/83332.Rv1306Probable ATP synthase B chain AtpF; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing t [...]
atpH protein networkhttps://string-db.org/network/83332.Rv1307Probable ATP synthase delta chain AtpH; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containi [...]
atpA protein networkhttps://string-db.org/network/83332.Rv1308Probable ATP synthase alpha chain AtpA; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta c [...]
atpG protein networkhttps://string-db.org/network/83332.Rv1309Probable ATP synthase gamma chain AtpG; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity a [...]
atpD protein networkhttps://string-db.org/network/83332.Rv1310Probable ATP synthase beta chain AtpD; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to th [...]
atpC protein networkhttps://string-db.org/network/83332.Rv1311Probable ATP synthase epsilon chain AtpC; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the ATPase epsilon chain family.
Rv1312 protein networkhttps://string-db.org/network/83332.Rv1312Rv1312, (MTCY373.32), len: 147 aa. Conserved hypothetical secreted protein with potential N-terminal signal sequence. Highly similar to P53432|Y02W_MYCLE hypothetical Mycobacterium leprae protein [...]
Rv1313c protein networkhttps://string-db.org/network/83332.Rv1313cPossible transposase; Rv1313c, (MTCY373.33c), len: 444 aa. Possible IS1557 transposase, similar to several transposases e.g. U57649|DBU57649 ORF1 from dibenzofuran-degrading bacterium DPO360 (163 [...]
Rv1314c protein networkhttps://string-db.org/network/83332.Rv1314cConserved protein; Rv1314c, (MTCY373.34c), len: 193 aa. Conserved protein, highly similar to P53523|Y02Y_MYCLE hypothetical Mycobacterium leprae protein (191 aa), FASTA score: opt:1019, E(): 0, ( [...]
murA protein networkhttps://string-db.org/network/83332.Rv1315Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
ogt protein networkhttps://string-db.org/network/83332.Rv1316cMethylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the [...]
alkA protein networkhttps://string-db.org/network/83332.Rv1317cProbable bifunctional transcriptional activator/DNA repair enzyme AlkA; Is involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs the Sp diastereomer o [...]
Rv1318c protein networkhttps://string-db.org/network/83332.Rv1318cPossible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1318c, (MTCY130.03c), len: 541 aa. Possible adenylate cyclase. Some similarity at the c-terminus to CYAA_RHIME|P19485 ad [...]
Rv1319c protein networkhttps://string-db.org/network/83332.Rv1319cPossible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1319c, (MTCY130.04c), len: 535 aa. Possible adenylate cyclase. Some similarity at the C-terminus to CYAA_RHIME|P19485 ad [...]
Rv1320c protein networkhttps://string-db.org/network/83332.Rv1320cPossible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1320c, (MTCY130.05c), len: 567 aa. Possible adenylate cyclase (see Rindi et al., 1999). Some similarity at the C-terminu [...]
nucS protein networkhttps://string-db.org/network/83332.Rv1321Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
Rv1322 protein networkhttps://string-db.org/network/83332.Rv1322Rv1322, (MTCY130.07), len: 98 aa. Conserved hypothetical protein.
Rv1322A protein networkhttps://string-db.org/network/83332.Rv1322ARv1322A, len: 152 aa. Conserved protein, similar to proteins from Mycobacterium leprae and Streptomyces coelicolor e.g. AL583921_2|ML1157 from M. leprae strain tn (155 aa), FASTA scores: opt: 771 [...]
fadA4 protein networkhttps://string-db.org/network/83332.Rv1323Rv1323, (MTCY130.08), len: 389 aa. Probable fadA4,acetyl-CoA acetyltransferase, equivalent to THIL_MYCLE|P46707 possible acetyl-CoA C-acetyltransferase from Mycobacterium leprae (393 aa), FASTA s [...]
Rv1324 protein networkhttps://string-db.org/network/83332.Rv1324Possible thioredoxin; Rv1324, (MTCY130.09), len: 304 aa. Possible thioredoxin, similar to several e.g. U00014|Q49716 TRXA from Mycobacterium leprae (255 aa), FASTA scores: opt: 1014, E(): 0, (69. [...]
PE_PGRS24 protein networkhttps://string-db.org/network/83332.Rv1325cPE-PGRS family protein PE_PGRS24; Rv1325c, (MTCY130.10c), len: 603 aa. PE_PGRS24,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of ala-, gly-rich proteins (see Brennan & Delog [...]
glgB protein networkhttps://string-db.org/network/83332.Rv1326c1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme); Essential enzyme that catalyzes the formation of the alpha- 1,6-glucosidic linkages in glucan chains by scission of a 1,4-alpha [...]
glgE protein networkhttps://string-db.org/network/83332.Rv1327cProbable glucanase GlgE; Essential maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)- glucans. Maltooligosaccharides with a de [...]
glgP protein networkhttps://string-db.org/network/83332.Rv1328Probable glycogen phosphorylase GlgP; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their [...]
dinG protein networkhttps://string-db.org/network/83332.Rv1329cProbable ATP-dependent helicase DinG; Probable helicase involved in DNA repair and perhaps also replication; Belongs to the helicase family. DinG subfamily.
pncB1 protein networkhttps://string-db.org/network/83332.Rv1330cNicotinic acid phosphoribosyltransferase PncB1; Involved in the Preiss-Handler pathway, which is a recycling route that permits the salvage of free nicotinamide (NM) and nicotinic acid (Na) invol [...]
clpS protein networkhttps://string-db.org/network/83332.Rv1331Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
Rv1332 protein networkhttps://string-db.org/network/83332.Rv1332Rv1332, (MTCY130.17), len: 218 aa. Possible regulatory protein, high similarity to ML014|U00014 M. leprae B1549_C3_236 (222 aa), FASTA scores: opt: 1158, E(): 0, (75.6% identity in 221 aa overlap [...]
Rv1333 protein networkhttps://string-db.org/network/83332.Rv1333Probable hydrolase; Aminopeptidase; Belongs to the peptidase S58 family.
mec protein networkhttps://string-db.org/network/83332.Rv1334Possible hydrolase; Protease that hydrolyzes the covalent CysO-cysteine adduct synthesized by CysM to release L-cysteine and regenerate CysO.
cysO protein networkhttps://string-db.org/network/83332.Rv1335Sulfur carrier protein CysO; In its thiocarboxylated form (CysO-COSH), is the sulfur donor in the CysM-dependent cysteine biosynthetic pathway. May be of particular importance for cysteine biosyn [...]
cysM protein networkhttps://string-db.org/network/83332.Rv1336O-phosphoserine sulfhydrylase; Catalyzes the formation of a covalent CysO-cysteine adduct via a sulfur transfer, using the thiocarboxylated sulfur carrier protein CysO-COSH as sulfur donor and O- [...]
Rv1337 protein networkhttps://string-db.org/network/83332.Rv1337Rv1337, (MTCY130.22), len: 240 aa. Probable integral membrane protein. Highly similar to P53426 hypothetical protein B1549_C3_240 from M.leprae (251); and P74553|D90916 hypothetical protein from [...]
murI protein networkhttps://string-db.org/network/83332.Rv1338Probable glutamate racemase MurI; Provides the (R)-glutamate required for cell wall biosynthesis.
Rv1339 protein networkhttps://string-db.org/network/83332.Rv1339Conserved protein; Rv1339, (MTCY130.24), len: 273 aa. Conserved protein, highly similar to Y211_MYCLE|P50474 hypothetical protein b1549_c2_211 from Mycobacterium leprae (284 aa),FASTA scores: opt [...]
rphA protein networkhttps://string-db.org/network/83332.Rv1340Probable ribonuclease RphA (RNase PH) (tRNA nucleotidyltransferase); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues follo [...]
Rv1341 protein networkhttps://string-db.org/network/83332.Rv1341Conserved protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XT [...]
Rv1342c protein networkhttps://string-db.org/network/83332.Rv1342cConserved membrane protein; Rv1342c, (MTCY02B10.06c), len: 120 aa. Conserved membrane protein. Highly similar to G466926|P54133 hypothetical protein B1549_F2_59 from Mycobacterium leprae (119 aa) [...]
lprD protein networkhttps://string-db.org/network/83332.Rv1343cRv1343c, (MTCY02B10.07c), len: 126 aa. Probable lprD, conserved lipoprotein, highly similar to G466928 Mycobacterium leprae protein B1549_F3_106 (126 aa), FASTA scores, opt: 704, E(): 7.5e-36, (7 [...]
mbtL protein networkhttps://string-db.org/network/83332.Rv1344Acyl carrier protein (ACP) MbtL; Acyl carrier protein involved in the formation of acyl-S-ACP intermediates within the mycobactin biosynthesis process. The aliphatic chains carried by ACP are sub [...]
mbtM protein networkhttps://string-db.org/network/83332.Rv1345Probable fatty acyl-AMP ligase MbtM; Activates lipidic moieties required for mycobactin biosynthesis. Converts medium- to long-chain aliphatic fatty acids into acyl adenylate, which is further tr [...]
mbtN protein networkhttps://string-db.org/network/83332.Rv1346Acyl-CoA dehydrogenase MbtN; Catalyzes the dehydrogenation at the alpha-beta position of ACP-bound acyl chains. This results in the introduction of a double bond in the lipidic chain, which is fu [...]
mbtK protein networkhttps://string-db.org/network/83332.Rv1347cLysine N-acetyltransferase MbtK; Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysin [...]
irtA protein networkhttps://string-db.org/network/83332.Rv1348Iron-regulated transporter IrtA; Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is res [...]
irtB protein networkhttps://string-db.org/network/83332.Rv1349Iron-regulated transporter IrtB; Part of the ABC transporter complex IrtAB involved in iron import. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is res [...]
fabG2 protein networkhttps://string-db.org/network/83332.Rv1350Uncharacterized oxidoreductase Rv1350; Rv1350, (MTCY02B10.14), len: 247 aa. Probable fabG2,3-oxoacyl-[acyl-carrier protein] reductase, highly similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl [...]
Rv1351 protein networkhttps://string-db.org/network/83332.Rv1351Hypothetical protein; Rv1351, (MTCY02B10.15), len: 109 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al., 2008). This region is a possible MT-complex-sp [...]
Rv1352 protein networkhttps://string-db.org/network/83332.Rv1352Conserved protein; Rv1352, (MTCY02B10.16), len: 123 aa. Conserved protein, some similarity to Rv1906c|MTCY180.12 hypothetical protein from Mycobacterium tuberculosis (156 aa), FASTA scores: E(): [...]
Rv1353c protein networkhttps://string-db.org/network/83332.Rv1353cProbable transcriptional regulatory protein; Negatively regulates the expression of the efflux pump Rv0191 upon chloramphenicol exposure. Acts by binding to the Rv0191 promoter region.
Rv1354c protein networkhttps://string-db.org/network/83332.Rv1354cConserved hypothetical protein; Rv1354c, (MTCY02B10.18c), len: 623 aa. Conserved hypothetical protein, similar to many hypothetical proteins e.g. the C-terminus of G1001455 Synechocystis sp. (124 [...]
moeY protein networkhttps://string-db.org/network/83332.Rv1355cRv1355c, (MTCY02B10.19c), len: 715 aa. Possible moeY, Molybdopterin biosynthesis protein, very weak similarity to MOEB_ECOLI|P12282 molybdopterin biosynthesis moeb protein (249 aa), FASTA scores, [...]
Rv1356c protein networkhttps://string-db.org/network/83332.Rv1356cHypothetical protein; Rv1356c, (MTCY02B10.20c), len: 263 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1357c protein networkhttps://string-db.org/network/83332.Rv1357cConserved hypothetical protein; Rv1357c, (MTCY02B10.21c), len: 307 aa. Conserved hypothetical protein, similar to members of the YEGE/YHJK/YJCC family e.g. Y4LL_RHISN|P55552 hypothetical protein [...]
Rv1358 protein networkhttps://string-db.org/network/83332.Rv1358Rv1358, (MTCY02B10.22), len: 1159 aa. Probable transcriptional regulatory protein, some similarity to AFSR_STRCO|P25941 regulatory protein afsr from Streptomyces coelicolor (993 aa), FASTA scores [...]
Rv1359 protein networkhttps://string-db.org/network/83332.Rv1359Rv1359, (MTCY02B10.23), len: 250 aa. Probable transcriptional regulatory protein, similar to Rv0891c|MTCY31.19c, (48.5% identity in 204 aa overlap) and to Rv1358|MTCY02B10.22 (43.7% identity in 1 [...]
Rv1360 protein networkhttps://string-db.org/network/83332.Rv1360Rv1360, (MTCY02B10.24), len: 340 aa. Probable oxidoreductase. Similar to Q49598|G1002714 coenzyme F420-dependent n5, n10-methylenetetrahydromethanopterin reductase from Methanopyrus kandleri (349 [...]
PPE19 protein networkhttps://string-db.org/network/83332.Rv1361cRv1361c, (MTCY02B10.25c), len: 396 aa. PPE19 (alternate gene name: mtb39b). Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, highly similar to many e.g. Rv1196|MTCI36 [...]
Rv1362c protein networkhttps://string-db.org/network/83332.Rv1362cPossible membrane protein; Rv1362c, (MTCY02B10.26c), len: 220 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1362c|MTCY02B10.27c (25.9% identity [...]
Rv1363c protein networkhttps://string-db.org/network/83332.Rv1363cPossible membrane protein; Rv1363c, (MTCY02B10.27c), len: 261 aa. Possible membrane protein, similar to Mycobacterium tuberculosis hypothetical proteins Rv1362c|MTCY02B10.26c (25.9% identity in 2 [...]
Rv1364c protein networkhttps://string-db.org/network/83332.Rv1364cRv1364c, (MTCY02B10.28c), len: 653 aa. Possible sigma factor regulatory protein, some similarity to RSBU_BACSU|P40399 sigma factor sibg regulation protein from Bacillus subtilis (335 aa), FASTA s [...]
rsfA protein networkhttps://string-db.org/network/83332.Rv1365cAnti-anti-sigma factor RsfA (anti-sigma factor antagonist) (regulator of sigma F A); Positive, redox-sensitive regulator of sigma-F (SigF) activity. When reduced binds to anti-sigma-F factor RsbW [...]
Rv1366 protein networkhttps://string-db.org/network/83332.Rv1366Hypothetical protein; Rv1366, (MTCY02B10.30), len: 273 aa. Hypothetical unknown protein.
Rv1366A protein networkhttps://string-db.org/network/83332.Rv1366ARv1366A, len: 86 aa. Conserved protein.
Rv1367c protein networkhttps://string-db.org/network/83332.Rv1367cConserved protein; Rv1367c, (MTCY02B12.01c,MTCY02B10.31c), len: 377 aa. Conserved protein. Some similarity to penicillin binding proteins e.g. PBPE_BACSU|P32959 penicillin-binding protein 4* (pbp [...]
lprF protein networkhttps://string-db.org/network/83332.Rv1368Probable conserved lipoprotein LprF; Might be involved in transporting short diacylated glycolipids to the cell outer membrane (By similarity). Overexpression induces expression of sensor protein [...]
Rv1369c protein networkhttps://string-db.org/network/83332.Rv1369cProbable transposase; Rv1369c, (MTCY02B12.03c), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase describe [...]
Rv1370c protein networkhttps://string-db.org/network/83332.Rv1370cRv1370c, (MTCY02B12.04c), len: 108 aa. Putative transposase for IS6110 (fragment), identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion [...]
Rv1371 protein networkhttps://string-db.org/network/83332.Rv1371Rv1371, (MTCY02B12.05), len: 489 aa. Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173 [...]
pks18 protein networkhttps://string-db.org/network/83332.Rv1372Conserved hypothetical protein; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using [...]
Rv1373 protein networkhttps://string-db.org/network/83332.Rv1373Glycolipid sulfotransferase; Involved in the synthesis of cell wall sulfolipids with activity towards mycobacterial trehalose glycolipids and eukaryotic glycolipids such as glucosylceramide and g [...]
Rv1374c protein networkhttps://string-db.org/network/83332.Rv1374cHypothetical protein; Rv1374c, (MTCY02B12.08c), len: 152 aa. Hypothetical unknown protein.
Rv1375 protein networkhttps://string-db.org/network/83332.Rv1375Rv1375, (MTCY02B12.09), len: 439 aa. Conserved hypothetical protein, similar to hypothetical proteins from several organisms e.g. Q52871|U39409 Rhizobium leguminosarum (420 aa), FASTA scores: E() [...]
Rv1376 protein networkhttps://string-db.org/network/83332.Rv1376Rv1376, (MTCY02B12.10), len: 497 aa. Conserved hypothetical protein, some similarity to hypothetical proteins from several organisms e.g. Q52872|U39409 Rhizobium leguminosarum (247 aa), FASTA sco [...]
Rv1377c protein networkhttps://string-db.org/network/83332.Rv1377cPutative transferase; Rv1377c, (MTCY02B12.11c), len: 212 aa. Putative transferase, similar to YQEM_BACSU|P54458 hypothetical 28.3 kDa protein from Bacillus subtilis (247 aa), FASTA scores: opt: 2 [...]
Rv1378c protein networkhttps://string-db.org/network/83332.Rv1378cConserved hypothetical protein; Rv1378c, (MTCY02B12.12c), len: 475 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. Rv3074|MTCY22D7.07C ( [...]
pyrR protein networkhttps://string-db.org/network/83332.Rv1379Probable pyrimidine operon regulatory protein PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.
pyrB protein networkhttps://string-db.org/network/83332.Rv1380Rv1380, (MTCY02B12.14), len: 319 aa. Probable pyrB,aspartate carbamoyltransferase, similar to many e.g. PYRB_BACCL|P41008 aspartate carbamoyltransferase from Bacillus caldolyticus (308 aa), FASTA [...]
pyrC protein networkhttps://string-db.org/network/83332.Rv1381Probable dihydroorotase PyrC (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class [...]
Rv1382 protein networkhttps://string-db.org/network/83332.Rv1382Rv1382, (MTCY02B12.16), len: 165 aa. Possible exported or membrane protein, hydrophobic domain at N-terminus. Predicted to be an outer membrane protein (See Song et al., 2008).
carA protein networkhttps://string-db.org/network/83332.Rv1383Rv1383, (MTCY02B12.17), len: 376 aa. Probable carA,Carbamoyl-phosphate synthase small chain, similar to many e.g. CARA_ECOLI|P00907 carbamoyl-phosphate synthase small chain from Escherichia coli [...]
carB protein networkhttps://string-db.org/network/83332.Rv1384Carbamoyl-phosphate synthase large chain; Rv1384, (MTCY02B12.18-MTCY21B4.01), len: 1115 aa. Probable carB, Carbamoyl-phosphate synthase large chain, similar to many e.g. CARB_ECOLI|P00968 E. coli [...]
pyrF protein networkhttps://string-db.org/network/83332.Rv1385Rv1385, (MTCY21B4.02), len: 274 aa. Probable pyrF,orotidine 5'-phosphate decarboxylase, identical to DCOP_MYCBO|P42610 Mycobacterium bovis (274 aa). Contains PS00156 Orotidine 5'-phosphate decarb [...]
PE15 protein networkhttps://string-db.org/network/83332.Rv1386PE family protein PE15; May play a pivotal role in the evasion of host immune response by M.tuberculosis. Mediates production of IL-10 via activation of the p38 and ERK1/2 mitogen-activated prote [...]
PPE20 protein networkhttps://string-db.org/network/83332.Rv1387Rv1387, (MTCY21B4.04), len: 539 aa. PPE20, Member of Mycobacterium tuberculosis PPE family of proteins, similar to many e.g. Y05F_MYCTU|Q10892 hypothetical 46.9 kd protein cy251.15 (463 aa), FAST [...]
mihF protein networkhttps://string-db.org/network/83332.Rv1388Rv1388, (MTCY21B4.05), len: 190 aa. Putative mihF,integration host factor. Almost identical to, but longer than, P96802|U75344 Mycobacterium smegmatis integration host factor (mIHF) for mycobacte [...]
gmk protein networkhttps://string-db.org/network/83332.Rv1389Probable guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP.
rpoZ protein networkhttps://string-db.org/network/83332.Rv1390DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alp [...]
dfp protein networkhttps://string-db.org/network/83332.Rv1391Probable DNA/pantothenate metabolism flavoprotein homolog Dfp; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenat [...]
metK protein networkhttps://string-db.org/network/83332.Rv1392S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formati [...]
Rv1393c protein networkhttps://string-db.org/network/83332.Rv1393cProbable monoxygenase; Rv1393c, (MTCY21B4.10c), len: 492 aa. Probable monooxygenase, similar to others e.g. CYMO_ACISP|P12015 cyclohexanone monooxygenase from Acinetobacter sp. (542 aa), FASTA sc [...]
cyp132 protein networkhttps://string-db.org/network/83332.Rv1394cRv1394c, (MT1439, MTCY21B4.11c), len: 461 aa. Probable cyp132, cytochrome P450 132. Some similarity to others e.g. CP4B_HUMAN|P13584 human cytochrome p450 (511 aa), FASTA scores: opt: 486, E(): 7 [...]
Rv1395 protein networkhttps://string-db.org/network/83332.Rv1395Rv1395, (MTCY21B4.12), len: 344 aa. Transcriptional regulatory protein (see citation below), similar to many e.g. URER_PROMI|Q02458 urease operon transcriptional activator from Proteus mirabilis [...]
PE_PGRS25 protein networkhttps://string-db.org/network/83332.Rv1396cPE-PGRS family protein PE_PGRS25; Rv1396c, (MTCY21B4.13c), len: 576 aa. PE_PGRS25,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 200 [...]
vapC10 protein networkhttps://string-db.org/network/83332.Rv1397cPossible toxin VapC10; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB10 (By similarity). Belongs to the PINc/VapC protein family.
vapB10 protein networkhttps://string-db.org/network/83332.Rv1398cPossible antitoxin VapB10; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC10.
nlhH protein networkhttps://string-db.org/network/83332.Rv1399cProbable non lipolytic carboxylesterase NlhH; Hydrolyzes various short-chain esters, such as triacylglycerols and vinyl esters. Has no activity against emulsified substrates.
lipI protein networkhttps://string-db.org/network/83332.Rv1400cProbable lipase LipH; Esterase that can hydrolyze short-chain esters with the carbon chain containing 2 to 12 carbon atoms. In vitro, pNP-butyrate is the preferred substrate.
Rv1401 protein networkhttps://string-db.org/network/83332.Rv1401Possible membrane protein; Rv1401, (MTCY21B4.18), len: 200 aa. Possible membrane protein.
priA protein networkhttps://string-db.org/network/83332.Rv1402Putative primosomal protein N' PriA (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. [...]
Rv1403c protein networkhttps://string-db.org/network/83332.Rv1403cRv1403c, (MTCY21B4.20c), len: 274 aa. Putative methyltransferase, similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa),FASTA scores: opt: 217, E(): 1.1e-07, (37.1% i [...]
Rv1404 protein networkhttps://string-db.org/network/83332.Rv1404Rv1404, (MTCY21B4.21), len: 160 aa. Probable transcriptional regulatory protein, some similarity to MARR_ECOLI|P27245 multiple antibiotic resistance protein from Escherichia coli (125 aa), FASTA [...]
Rv1405c protein networkhttps://string-db.org/network/83332.Rv1405cRv1405c, (MTCY21B4.22c), len: 274 aa. Putative methyltransferase, most similar to PMTA_RHOSH|Q05197 phosphatidylethanolamine m-methyltransferase (203 aa),FASTA scores: opt: 219, E(): 2.6e-07, (29 [...]
fmt protein networkhttps://string-db.org/network/83332.Rv1406Probable methionyl-tRNA formyltransferase Fmt; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of [...]
fmu protein networkhttps://string-db.org/network/83332.Rv1407Probable Fmu protein (sun protein); May act as RNA methyltransferase.
rpe protein networkhttps://string-db.org/network/83332.Rv1408Probable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase); Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs t [...]
ribG protein networkhttps://string-db.org/network/83332.Rv1409Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphat [...]
Rv1410c protein networkhttps://string-db.org/network/83332.Rv1410cAminoglycosides/tetracycline-transport integral membrane protein; In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplas [...]
lprG protein networkhttps://string-db.org/network/83332.Rv1411cConserved lipoprotein LprG; Probably helps membrane protein Rv1410c (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabol [...]
ribC protein networkhttps://string-db.org/network/83332.Rv1412Probable riboflavin synthase alpha chain RibC (RibE); Catalyzes the dismutation of two molecules of 6,7-dimethyl-8- ribityllumazine, resulting in the formation of riboflavin and 5-amino- 6-(D-rib [...]
Rv1413 protein networkhttps://string-db.org/network/83332.Rv1413Rv1413, (MTCY21B4.30), len: 171 aa. Conserved hypothetical protein, similar to part of AB010956|AB010956_1 metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA scores: opt: 187, [...]
Rv1414 protein networkhttps://string-db.org/network/83332.Rv1414Rv1414, (MTCY21B4.31), len: 133 aa. Conserved hypothetical protein, similar to C-terminal part of AB010956|AB010956_1 novel metal-activated pyridoxal enzyme from Arthrobacter sp. (379 aa), FASTA [...]
ribA2 protein networkhttps://string-db.org/network/83332.Rv14153,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DH [...]
ribH protein networkhttps://string-db.org/network/83332.Rv14166,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. [...]
Rv1417 protein networkhttps://string-db.org/network/83332.Rv1417Rv1417, (MTCY21B4.35), len: 154 aa. Possible conserved membrane protein, similar to others e.g. AL133213|SC6D7_2 Streptomyces coelicolor (156 aa), FASTA scores: opt: 212, E(): 4.4e-07, (32.4% ide [...]
lprH protein networkhttps://string-db.org/network/83332.Rv1418Rv1418, (MTCY21B4.36), len: 228 aa. Probable lprH,lipoprotein. Contains N-terminal signal sequence and appropriately positioned prokaryotic lipoprotein lipid attachment site (PS00013).
Rv1419 protein networkhttps://string-db.org/network/83332.Rv1419Unknown protein; Rv1419, (MTCY21B4.37), len: 157 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
uvrC protein networkhttps://string-db.org/network/83332.Rv1420Probable excinuclease ABC (subunit C-nuclease) UvrC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-t [...]
Rv1421 protein networkhttps://string-db.org/network/83332.Rv1421Conserved protein; Displays ATPase and GTPase activities; Belongs to the RapZ-like family.
Rv1422 protein networkhttps://string-db.org/network/83332.Rv1422Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions.
whiA protein networkhttps://string-db.org/network/83332.Rv1423Probable transcriptional regulatory protein WhiA; Involved in cell division and chromosome segregation.
Rv1424c protein networkhttps://string-db.org/network/83332.Rv1424cPossible membrane protein; Rv1424c, (MTCY21B4.42c,MTCY493.30), len: 253 aa. Possible membrane protein, contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature. [...]
Rv1425 protein networkhttps://string-db.org/network/83332.Rv1425Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
lipO protein networkhttps://string-db.org/network/83332.Rv1426cProbable esterase LipO; Rv1426c, (MTCY493.28), len: 420 aa. Possible lipO,esterase, similar to several Mycobacterium tuberculosis hypothetical lipases and esterases e.g. Rv1399c, Rv2284,etc. Also [...]
fadD12 protein networkhttps://string-db.org/network/83332.Rv1427cRv1427c, (MTCY493.27), len: 535 aa. Possible fadD12,long-chain-fatty-acid-CoA synthetase, similar to many e.g. NP_302632.1|NC_002677 acyl-CoA synthase from Mycobacterium leprae (548 aa); AAD01929 [...]
Rv1428c protein networkhttps://string-db.org/network/83332.Rv1428cRv1428c, (MTCY493.26), len: 275 aa. Conserved hypothetical protein, some similarity to hypothetical proteins from Mycobacterium tuberculosis e.g. Rv0502|YV29_MYCTU|Q11167 (358 aa), FASTA scores: [...]
Rv1429 protein networkhttps://string-db.org/network/83332.Rv1429Conserved protein; Rv1429, (MTCY493.25c), len: 422 aa. Conserved protein, some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherich [...]
PE16 protein networkhttps://string-db.org/network/83332.Rv1430PE family protein PE16; Esterase that hydrolyzes short to medium chain fatty acid esters with the highest specific activity for p-nitrophenyl caproate (pNPC6). Has lower activity with p-nitrophen [...]
Rv1431 protein networkhttps://string-db.org/network/83332.Rv1431Conserved membrane protein; Rv1431, (MTCY493.23c), len: 589 aa. Conserved membrane protein, shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% ident [...]
Rv1432 protein networkhttps://string-db.org/network/83332.Rv1432Rv1432, (MTCY493.22c), len: 473 aa. Probable dehydrogenase, shows strong similarity to P49_STRLI|P06108 p49 protein from Streptomyces lividans (469 aa), FASTA scores: opt: 1362, E(): 0, (44.9% id [...]
Rv1433 protein networkhttps://string-db.org/network/83332.Rv1433Possible conserved exported protein; Probable L,D-transpeptidase that may perform as-yet-unknown cross-linking reactions in M.tuberculosis. Is not able to generate 3->3 cross-links in peptidoglyc [...]
Rv1435c protein networkhttps://string-db.org/network/83332.Rv1435cRv1435c, (MTCY493.19), len: 202 aa. Probable conserved Pro-, Gly-, Val-rich secreted protein (see citation below) with a N-terminal signal sequence. Similar at C-terminus to AF017099|AF017099_1 M [...]
gap protein networkhttps://string-db.org/network/83332.Rv1436Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD [...]
pgk protein networkhttps://string-db.org/network/83332.Rv1437Rv1437, (MTCY493.17c), len: 412 aa. Probable pgk,Phosphoglycerate kinase, highly similar to many e.g. PGK_MYCLE|P46712 Mycobacterium leprae (416 aa), FASTA scores: opt: 2153, E(): 0, (80.4% ident [...]
tpi protein networkhttps://string-db.org/network/83332.Rv1438Probable triosephosphate isomerase Tpi (TIM); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G [...]
secG protein networkhttps://string-db.org/network/83332.Rv1440Probable protein-export membrane protein (translocase subunit) SecG; Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG famil [...]
PE_PGRS26 protein networkhttps://string-db.org/network/83332.Rv1441cPE-PGRS family protein PE_PGRS26; Rv1441c, (MTCY493.13), len: 491 aa. PE_PGRS26,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
bisC protein networkhttps://string-db.org/network/83332.Rv1442Rv1442, (MTCY493.12c), len: 766 aa. Probable bisC,Biotin sulfoxide reductase, similar to BISC_ECOLI|P20099 biotin sulfoxide reductase from Escherichia coli (739 aa),FASTA scores: opt: 1271, E():0 [...]
Rv1443c protein networkhttps://string-db.org/network/83332.Rv1443cUnknown protein; Rv1443c, (MTCY493.11), len: 161 aa. Unknown protein.
Rv1444c protein networkhttps://string-db.org/network/83332.Rv1444cUnknown protein; Rv1444c, (MTCY493.10), len: 136 aa. Unknown protein.
devB protein networkhttps://string-db.org/network/83332.Rv1445cProbable 6-phosphogluconolactonase DevB (6PGL); Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
opcA protein networkhttps://string-db.org/network/83332.Rv1446cRv1446c, (MTCY493.08), len: 303 aa. Putative opcA,OxPP cycle protein. Highly similar to S72774 B1496_F1_30 protein from Mycobacterium leprae (265 aa), FASTA scores: opt: 1056, E(): 0, (70.3% iden [...]
zwf2 protein networkhttps://string-db.org/network/83332.Rv1447cProbable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
tal protein networkhttps://string-db.org/network/83332.Rv1448cProbable transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
tkt protein networkhttps://string-db.org/network/83332.Rv1449cTransketolase Tkt (TK); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-pho [...]
PE_PGRS27 protein networkhttps://string-db.org/network/83332.Rv1450cPE-PGRS family protein PE_PGRS27; Rv1450c, (MTCY493.04), len: 1329 aa. PE_PGRS27,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu,20 [...]
ctaB protein networkhttps://string-db.org/network/83332.Rv1451Probable cytochrome C oxidase assembly factor CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl s [...]
PE_PGRS28 protein networkhttps://string-db.org/network/83332.Rv1452cPE-PGRS family protein PE_PGRS28; Rv1452c, (MTCY493.02), len: 741 aa. PE_PGRS28,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu,200 [...]
Rv1453 protein networkhttps://string-db.org/network/83332.Rv1453Rv1453, (MTCY493.01c), len: 421 aa. Possible transcriptional activator, similar to Q50018 putative transcriptional activator trx from Mycobacterium leprae (517 aa), FASTA scores: opt: 1719, E(): [...]
qor protein networkhttps://string-db.org/network/83332.Rv1454cProbable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein); Rv1454c, (MTV007.01c), len: 328 aa. Probable qor,quinone oxidoreductase, simiar to U87282|RCU87282_2 qu [...]
Rv1455 protein networkhttps://string-db.org/network/83332.Rv1455Conserved protein; Rv1455, (MTV007.02), len: 287 aa. Conserved protein,some similarity from aa 80-160 to Z99125|MLCL536.35c hypothetical Mycobacterium leprae protein (101 aa), FASTA scores: opt: [...]
Rv1456c protein networkhttps://string-db.org/network/83332.Rv1456cRv1456c, (MTV007.03c), len: 310 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.34 from Mycobacterium l [...]
Rv1457c protein networkhttps://string-db.org/network/83332.Rv1457cRv1457c, (MTV007.04c), len: 261 aa. Possible unidentified antibiotic-transport integral membrane protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.32 from Mycobacterium l [...]
Rv1458c protein networkhttps://string-db.org/network/83332.Rv1458cRv1458c, (MTV007.05c), len: 313 aa. Possible unidentified antibiotic-transport ATP-binding protein ABC transporter (see citation below), equivalent to Z99125|MLCL536.31 from Mycobacterium leprae [...]
Rv1459c protein networkhttps://string-db.org/network/83332.Rv1459cPossible conserved integral membrane protein; Catalyzes the addition of alpha-(1->6)-mannose residue. Belongs to the MptA/B family.
Rv1460 protein networkhttps://string-db.org/network/83332.Rv1460Rv1460, (MTV007.07), len: 268 aa. Probable transcriptional regulatory protein. Equivalent to Z99125|MLCL536.29c hypothetical protein from Mycobacterium leprae (254 aa), FASTA scores: opt: 1273, E [...]
Rv1461 protein networkhttps://string-db.org/network/83332.Rv1461Conserved protein; Rv1461, (MTV007.08), len: 846 aa. Conserved protein. Equivalent of spliced protein from Mycobacterium leprae MLCL536.28c len: 869. Residues 1-253 represent N-extein,and 613-846 [...]
Rv1462 protein networkhttps://string-db.org/network/83332.Rv1462Rv1462, (MTV007.09), len: 397 aa. Conserved hypothetical protein. Equivalent to MLCL536.27c|Z99125 hypothetical protein from Mycobacterium leprae (392 aa),FASTA scores: opt: 2059, E(): 0, (80.4% [...]
Rv1463 protein networkhttps://string-db.org/network/83332.Rv1463Rv1463, (MTV007.10), len: 266 aa. Probable conserved ATP-binding protein ABC transporter, equivalent to Z99125|MLCL536.26c putative ABC transporter ATP-binding protein from Mycobacterium leprae ( [...]
csd protein networkhttps://string-db.org/network/83332.Rv1464Probable cysteine desulfurase Csd; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; Belongs to [...]
Rv1465 protein networkhttps://string-db.org/network/83332.Rv1465Rv1465, (MTV007.12), len: 162 aa. Possible nitrogen fixation related protein. Equivalent to Z99125|MLCL536.24c nitrogen fixation protein NIFU from Mycobacterium leprae (165 aa), FASTA scores: opt [...]
Rv1466 protein networkhttps://string-db.org/network/83332.Rv1466Conserved protein; Rv1466, (MTV007.13), len: 115 aa. Conserved protein. Equivalent to Z99125|MLCL536.23c hypothetical protein from Mycobacterium leprae (115 aa), FASTA scores: opt: 648, E(): 0, ( [...]
fadE15 protein networkhttps://string-db.org/network/83332.Rv1467cRv1467c, (MTV007.14c), len: 609 aa. Probable fadE15,acyl-CoA dehydrogenase, highly similar to NP_302639.1|NC_002677 acyl-CoA dehydrogenase from Mycobacterium leprae (611 aa). Also highly similar [...]
PE_PGRS29 protein networkhttps://string-db.org/network/83332.Rv1468cPE-PGRS family protein PE_PGRS29; Rv1468c, (MTV007.15c), len: 370 aa. PE_PGRS29,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below).
ctpD protein networkhttps://string-db.org/network/83332.Rv1469Probable cation transporter P-type ATPase D CtpD; Involved in heavy metal homeostasis. Probably exports nickel and cobalt ions out of the cell (By similarity); Belongs to the cation transport ATP [...]
trxA protein networkhttps://string-db.org/network/83332.Rv1470Rv1470, (MTV007.17), len: 124 aa. Probable trxA,thioredoxin, similar to many e.g. P12243|THI1_SYNP7 thioredoxin 1 from Synechococcus sp. (106 aa), FASTA scores: opt: 201, E(): 9.2e-08, (35.4% ide [...]
trxB1 protein networkhttps://string-db.org/network/83332.Rv1471Rv1471, (MTV007.18), len: 123 aa. Probable trxB1,thioredoxin, similar to many bacterial thioredoxins e.g. P33636|THI2_ECOLI from Escherichia coli (139 aa), FASTA scores: opt: 290, E(): 1.8e-13, ( [...]
echA12 protein networkhttps://string-db.org/network/83332.Rv1472Possible enoyl-CoA hydratase EchA12 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Could possibly oxidize fatty acids using specific components.
Rv1473 protein networkhttps://string-db.org/network/83332.Rv1473Rv1473, (MTV007.20), len: 542 aa. Possible macrolide-transport ATP-binding protein ABC transporter (see citation below), possibly in EF-3 subfamily. Similar to many ABC-transporters e.g. D90909_4 [...]
Rv1473A protein networkhttps://string-db.org/network/83332.Rv1473ARv1473A, len: 63 aa. Possible transcriptional regulator, CDS predicted by GC plot. Similar to SCI8.24c|AL132644_24 putative transcriptional regulator from Streptomyces coelicolor (73 aa), FASTA s [...]
Rv1474c protein networkhttps://string-db.org/network/83332.Rv1474cProbable transcriptional regulatory protein; Represses the expression of the aconitase gene acn and its own expression, in an iron-responsive manner. Binds to the inverted repeat element present [...]
acn protein networkhttps://string-db.org/network/83332.Rv1475cProbable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase); Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation [...]
Rv1476 protein networkhttps://string-db.org/network/83332.Rv1476Possible membrane protein; Rv1476, (MTV007.23), len: 186 aa. Possibly membrane protein, TMhelix 138-60. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
ripA protein networkhttps://string-db.org/network/83332.Rv1477Peptidoglycan hydrolase; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds and degrades high-molecular weight peptidoglycan from a number of A [...]
ripB protein networkhttps://string-db.org/network/83332.Rv1478Possible invasion protein; Peptidoglycan endopeptidase that cleaves the bond between D- glutamate and meso-diaminopimelate. Binds high-molecular weight peptidoglycan, but does not degrade it. Req [...]
moxR1 protein networkhttps://string-db.org/network/83332.Rv1479Rv1479, (MTV007.26), len: 377 aa. Probable moxR1,transcriptional regulatory protein, similar to X96434|BBGIDBMOX_2 moxR regulator from Borrelia burgdorferi (329 aa), FASTA scores: opt: 850, E():0 [...]
Rv1480 protein networkhttps://string-db.org/network/83332.Rv1480Conserved protein; Rv1480, (MTV007.27,MTCY227.01), len: 317 aa. Conserved protein, last 110 aa residues correspond to first 110 aa of YS01_MYCAV|O07394 hypothetical 18.7 kDa Mycobacterium avium p [...]
Rv1481 protein networkhttps://string-db.org/network/83332.Rv1481Probable membrane protein; Rv1481, (MTCY277.02), len: 335 aa. Probable membrane protein, highly similar to YS02_MYCAV|O07395 hypothetical 36.1 kDa protein mav335 from Mycobacterium avium (335 aa) [...]
Rv1482c protein networkhttps://string-db.org/network/83332.Rv1482cRv1482c, (MTCY277.03c), len: 280 aa. Conserved hypothetical protein, highly similar to O07396|AF002133 Mycobacterium avium protein MAV346 (346 aa), FASTA scores: E(): 0, (65.2% identity in 342 aa [...]
fabG1 protein networkhttps://string-db.org/network/83332.Rv14833-oxoacyl-[acyl-carrier-protein] reductase FabG1; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongat [...]
inhA protein networkhttps://string-db.org/network/83332.Rv1484NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase); Enoyl-ACP reductase of the type II fatty acid syntase (FAS- II) system, which is involved in the b [...]
hemZ protein networkhttps://string-db.org/network/83332.Rv1485Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme.
Rv1486c protein networkhttps://string-db.org/network/83332.Rv1486cRv1486c, (MTCY277.07c), len: 288 aa. Conserved hypothetical protein, highly similar to YS07_MYCAV|O07402 hypothetical 33.5 kDa protein mav321 from Mycobacterium avium (320 aa), FASTA scores: opt: [...]
Rv1487 protein networkhttps://string-db.org/network/83332.Rv1487Conserved membrane protein; Rv1487, (MTCY277.08), len: 144 aa. Conserved membrane protein. Highly similar to O07404|AF002133 MAV145 from Mycobacterium avium (145 aa), FASTA scores: opt: 667,E(): [...]
Rv1488 protein networkhttps://string-db.org/network/83332.Rv1488Rv1488, (MTCY277.09), len: 381 aa. Possible exported conserved protein; contains possible N-terminal signal sequence. Similar to YBBK_ECOLI|P77367 hypothetical protein ybbK from Escherichia coli [...]
Rv1489 protein networkhttps://string-db.org/network/83332.Rv1489Rv1489, len: 118 aa. Conserved protein, similar to hypothetical proteins from Mycobacterium avium subsp. paratuberculosis and Streptomyces coelicolor e.g. AJ250017_1 insertion sequence IS900, Loc [...]
Rv1489A protein networkhttps://string-db.org/network/83332.Rv1489ARv1489A, len: 76 aa. Conserved protein, similar to part of alpha subunit of many methylmalonyl-CoA mutases (~750 aa). Size difference suggests possible gene fragment although Mycobacterium tuberc [...]
Rv1490 protein networkhttps://string-db.org/network/83332.Rv1490Probable membrane protein; Rv1490, (MTCY277.12), len: 435 aa. Probable membrane protein.
Rv1491c protein networkhttps://string-db.org/network/83332.Rv1491cConserved membrane protein; Rv1491c, (MTCY277.13c), len: 252 aa. Conserved membrane protein. Similar to hypothetical proteins from many organisms e.g. YDJZ_ECOLI|P76221 Escherichia coli (235 aa), [...]
mutA protein networkhttps://string-db.org/network/83332.Rv1492Probable methylmalonyl-CoA mutase small subunit MutA (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermed [...]
mutB protein networkhttps://string-db.org/network/83332.Rv1493Probable methylmalonyl-CoA mutase large subunit MutB (MCM); Catalyzes the isomerization of succinyl-CoA to methylmalonyl- CoA during synthesis of propionate from tricarboxylic acid-cycle intermed [...]
mazE4 protein networkhttps://string-db.org/network/83332.Rv1494Possible antitoxin MazE4; Antitoxin component of a type II toxin-antitoxin (TA) system. In M.smegmatis neutralizes the toxic effect of mRNA interferase MazF4, its cognate toxin, on growth.
mazF4 protein networkhttps://string-db.org/network/83332.Rv1495Possible toxin MazF4; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an endoribonuclease (mRNA interferase) on single-strand mRNA, cleaving between the first and second bases i [...]
Rv1496 protein networkhttps://string-db.org/network/83332.Rv1496Possible transport system kinase; Probable GTPase. May also bind and hydrolyze ATP. May function as chaperone (Probable); Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.
lipL protein networkhttps://string-db.org/network/83332.Rv1497Probable esterase LipL; Shows both esterase and beta-lactamase activities, with a much higher activity against phenyl esters than against beta-lactams. Shows esterase activity against both long-c [...]
Rv1498A protein networkhttps://string-db.org/network/83332.Rv1498ARv1498A, len: 70 aa. Conserved protein, highly similar to other hypothetical proteins e.g. from Streptomyces coelicolor, Sinorhizobium meliloti and Pseudomonas aeruginosa.
Rv1498c protein networkhttps://string-db.org/network/83332.Rv1498cRv1498c, (MTCY277.20c), len: 205 aa. Probable methyltransferase. Similar to G2792343|AF040571 methyltransferase from amycolatopsis mediterranei (272 aa),FASTA scores: E(): 5.1e-11, (32.3% identit [...]
Rv1499 protein networkhttps://string-db.org/network/83332.Rv1499Hypothetical protein; Rv1499, (MTCY277.21), len: 132 aa. Hypothetical unknown protein; was initially longer but has been shortened (-24 aa) owing to overlap with Rv1498A. This region is a possibl [...]
pimF protein networkhttps://string-db.org/network/83332.Rv1500Probable glycosyltransferase; May play only a redundant role in maintaining cell wall viability and bacterial virulence.
Rv1501 protein networkhttps://string-db.org/network/83332.Rv1501Rv1501, (MTCY277.23), len: 273 aa. Conserved hypothetical protein, some similarity to O06374|Rv3633|MTCY15C10.19C hypothetical protein from Mycobacterium tuberculosis, FASTA scores: E(): 3.9e-10, [...]
Rv1502 protein networkhttps://string-db.org/network/83332.Rv1502Hypothetical protein; Rv1502, (MTCY277.24), len: 299 aa. Hypothetical unknown protein.
Rv1503c protein networkhttps://string-db.org/network/83332.Rv1503cRv1503c, (MTCY277.25c), len: 182 aa. Conserved hypothetical protein, similar to C-terminal region of P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein from Escherichia coli (376 aa), FAST [...]
Rv1504c protein networkhttps://string-db.org/network/83332.Rv1504cRv1504c, (MTCY277.26c), len: 199 aa. Conserved hypothetical protein, similar to N-terminal region of P27833|RFFA_ECOLI lipopolysaccharide biosynthesis protein from Escherichia coli (376 aa), FAST [...]
Rv1505c protein networkhttps://string-db.org/network/83332.Rv1505cRv1505c, (MTCY277.27c), len: 221 aa. Conserved hypothetical protein, some similarity to hypothetical proteins and glycosylases e.g. P71063|O08181 hypothetical 22.5 kDa protein YVFD from Bacillus [...]
Rv1506c protein networkhttps://string-db.org/network/83332.Rv1506cHypothetical protein; Probably plays a role in host phagosome maturation arrest, as well as a role in the synthesis of acyltrehalose-containing glycolipids ; Belongs to the methyltransferase supe [...]
Rv1507A protein networkhttps://string-db.org/network/83332.Rv1507ARv1507A, len: 167 aa. Hypothetical unknow protein. Shows weak similarity with C-terminus of Q9XHQ7|CDA9 cytidine deaminase 9 from Arabidopsis thaliana (Mouse-ear cress) (298 aa), FASTA scores: op [...]
Rv1507c protein networkhttps://string-db.org/network/83332.Rv1507cConserved protein; Rv1507c, (MTCY277.29c), len: 231 aa. Conserved protein. Similar to AJ007747|BBR007747_6 Hypothetical protein BbLPS1.06 from Bordetella bronchiseptica cosmid (239 aa), FASTA sco [...]
Rv1508A protein networkhttps://string-db.org/network/83332.Rv1508ARv1508A, len: 120 aa. Conserved hypothetical protein, highly similar to central part of glycosyl transferases from various mycobacteria and eubacteria e.g. P71790|MTCY277.33|Rv1511 Hypothetical p [...]
Rv1508c protein networkhttps://string-db.org/network/83332.Rv1508cProbable membrane protein; Rv1508c, (MTCY277.30c), len: 599 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian, 2003). Probable membrane protein.
Rv1509 protein networkhttps://string-db.org/network/83332.Rv1509Hypothetical protein; Rv1509, (MTCY277.31), len: 293 aa. Hypothetical unknown protein.
Rv1510 protein networkhttps://string-db.org/network/83332.Rv1510Rv1510, (MTCY277.32), len: 432 aa. Probable membrane protein. Highly similar to Rv3630|MTCY15C10.22 (431 aa),FASTA scores: E(): 0, (70.8% identity in 424 aa overlap).
gmdA protein networkhttps://string-db.org/network/83332.Rv1511GDP-D-mannose dehydratase GmdA (GDP-mannose 4,6 dehydratase) (GMD); Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
epiA protein networkhttps://string-db.org/network/83332.Rv1512Probable nucleotide-sugar epimerase EpiA; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Rv1513 protein networkhttps://string-db.org/network/83332.Rv1513Conserved protein; Rv1513, (MTCY277.35), len: 243 aa. Conserved protein, similar to hypothetical proteins from several organisms e.g. AJ223833|MAP223833_3 from Mycobacterium avium paratuberculosi [...]
Rv1514c protein networkhttps://string-db.org/network/83332.Rv1514cRv1514c, (MTCY277.36c), len: 262 aa. Conserved hypothetical protein. Similar to other hypothetical proteins, and to WCAE_ECOLI|P71239 putative colanic acid biosynthesis glycosyl transferase (248 [...]
Rv1515c protein networkhttps://string-db.org/network/83332.Rv1515cRv1515c, (MTCY277.37c), len: 298 aa. Conserved hypothetical protein, similar to P71805|MTCY02B12.11C|Rv1377c Hypothetical protein from Mycobacterium tuberculosis, FASTA scores: E(): 1.3e-05,(25.4 [...]
Rv1516c protein networkhttps://string-db.org/network/83332.Rv1516cRv1516c, (MTCY277.38c), len: 336 aa. Probable sugar transferase, similar to AB010970|AB010970_6 glycosyltransferase from Streptococcus mutans (465 aa),FASTA scores: opt: 388, E(): 4.1e-18, (32.7% [...]
Rv1517 protein networkhttps://string-db.org/network/83332.Rv1517Rv1517, (MTCY277.39), len: 254 aa. Conserved hypothetical transmembrane protein, similar to G466802|LEPB1170_F2_64 from Mycobacterium leprae (230 aa),FASTA scores: opt: 282, E(): 2.2e-11, (34.1% [...]
Rv1518 protein networkhttps://string-db.org/network/83332.Rv1518Conserved hypothetical protein; Rv1518, (MTCY277.40, MTCY19G5.11c), len: 319 aa. Conserved hypothetical protein, possibly glycosyl transferase involved in exopolysaccharide synthesis,similar to s [...]
Rv1519 protein networkhttps://string-db.org/network/83332.Rv1519Rv1519, (MTCY19G5.09c), len: 89 aa. Conserved hypothetical protein, high similarity to C-terminus of Q50723|MTCY78.26|Rv3402c (412 aa) (58.1% identity in 74 aa overlap); To M.tuberculosis Rv3402c [...]
Rv1520 protein networkhttps://string-db.org/network/83332.Rv1520Rv1520, (MTCY19G5.08c), len: 346 aa. Probable sugar transferase, similar to several e.g. AB010970|AB010970_6 Streptococcus mutans glycosyltransferase (465 aa), FASTA scores: opt: 381, E(): 1.2e-1 [...]
fadD25 protein networkhttps://string-db.org/network/83332.Rv1521Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1521, (MTCY19G5.07), len: 583 aa. Probable fadD25,fatty-acid-AMP synthetase, highly similar to many [...]
mmpL12 protein networkhttps://string-db.org/network/83332.Rv1522cRv1522c, (MTCY19G5.06), len: 1146 aa. Probable mmpL12, conserved transmembrane transport protein (see Tekaia et al., 1999), member of RND superfamily. Strong similarity to many Mycobacterial memb [...]
Rv1523 protein networkhttps://string-db.org/network/83332.Rv1523Probable methyltransferase; Rv1523, (MTCY19G5.05c), len: 347 aa (start uncertain). Probable methyltransferase, similar to G560513|U0002O Mycobacterium leprae (270 aa), FASTA scores: opt: 965, E() [...]
Rv1524 protein networkhttps://string-db.org/network/83332.Rv1524Rv1524, (MTCY19G5.04c), len: 414 aa. Probable glycosyltransferase, similar to many e.g. P96559|U84349 glycosyltransferase GTFB from Amycolatopsis orientalis (407 aa), FASTA scores: opt: 363, E(): [...]
wbbL2 protein networkhttps://string-db.org/network/83332.Rv1525Rv1525, (MT1576, MTCY19G5.03c), len: 261 aa. Possible wbbL2, rhamnosyl transferase (see citation below),showing weak similarity to several rhamnosyl transferases. Similar to AF105060|AF105060_1 R [...]
Rv1526c protein networkhttps://string-db.org/network/83332.Rv1526cRv1526c, (MTCY19G5.02), len: 426 aa. Probable glycosyltransferase, highly similar to G467196 Protein L518_C2_147 from Mycobacterium leprae (421 aa), FASTA scores, opt: 1497, E(): 0, (55.0% identi [...]
pks5 protein networkhttps://string-db.org/network/83332.Rv1527cProbable polyketide synthase Pks5; Polyketide synthase likely involved in the biosynthesis of a polymethyl-branched fatty acid (PMB-FA) that might only be produced during host infection. Is requi [...]
papA4 protein networkhttps://string-db.org/network/83332.Rv1528cRv1528c, (MTV045.02), len: 165 aa. Probable papA4,conserved polyketide synthase (PKS) associated protein; shows some similarity to C-terminal part of hypothetical proteins from Mycobacterium tube [...]
fadD24 protein networkhttps://string-db.org/network/83332.Rv1529Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Rv1529, (MTV045.03), len: 584 aa. Probable fadD24,fatty-acid-AMP synthetase, highly similar to many e. [...]
adh protein networkhttps://string-db.org/network/83332.Rv1530Rv1530, (MTV045.04), len: 367 aa. Probable adh,alcohol dehydrogenase, zinc-dependent, similar to many e.g. AE0009|AE000958_23 Archaeoglobus fulgidus section 1 (402 aa), FASTA scores: opt: 423, E( [...]
Rv1531 protein networkhttps://string-db.org/network/83332.Rv1531Conserved protein; Rv1531, (MTV045.05), len: 188 aa. Conserved protein,similar to Rv0464c|MTV038.08c (190 aa), FASTA scores: E(): 4.8e-10, (30.9% identity in 175 aa overlap).
Rv1532c protein networkhttps://string-db.org/network/83332.Rv1532cConserved hypothetical protein; Rv1532c, (MTCY07A7A.01c), len: 144 aa. Conserved hypothetical protein, similar to P20378|YPHR_HALHA Hypothetical 15.6 kDa protein from Halobacterium halobium (151 [...]
Rv1533 protein networkhttps://string-db.org/network/83332.Rv1533Conserved protein; Rv1533, (MTCY07A7A.02), len: 375 aa. Conserved protein. Similar to 2NPD_NEUCR|Q01284 2-nitropropane dioxygenase precursor (378 aa), fasta scores: opt: 279,E(): 9.1e-11, (31.3% [...]
Rv1534 protein networkhttps://string-db.org/network/83332.Rv1534Rv1534, (MTCY07A7A.03), len: 225 aa. Probable transcriptional regulator, similar to YCDC_ECOLI|P75899 hypothetical transcriptional regulator from Escherichia coli (212 aa), FASTA scores: opt: 166 [...]
Rv1535 protein networkhttps://string-db.org/network/83332.Rv1535Unknown protein; Rv1535, (MTCY07A7A.04), len: 78 aa. Unknown protein.
ileS protein networkhttps://string-db.org/network/83332.Rv1536Isoleucyl-tRNA synthetase IleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid s [...]
dinX protein networkhttps://string-db.org/network/83332.Rv1537Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at s [...]
ansA protein networkhttps://string-db.org/network/83332.Rv1538cRv1538c, (MTCY48.27), len: 326 aa. Probable ansA,L-aparaginase, most similar to ASPG_BACLI|P30363 L-asparaginase (322 aa), FASTA scores: opt: 417, E(): 8.8e-19, (30.9% identity in 314 aa overlap) [...]
lspA protein networkhttps://string-db.org/network/83332.Rv1539Probable lipoprotein signal peptidase LspA; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.
Rv1540 protein networkhttps://string-db.org/network/83332.Rv1540Rv1540, (MTCY48.25c), len: 308 aa. Member of the yabO/yceC/yfiI family of hypothetical proteins, similar to P44445|YFII_HAEIN hypothetical protein HI0176 from Haemophilus influenzae (324 aa), FAS [...]
lprI protein networkhttps://string-db.org/network/83332.Rv1541cPossible lipoprotein LprI; Strongly binds and inhibits lysozyme, may help bacteria survive in lysozyme-producing host cells. When overexpressed in M.tuberculosis or M.smegmatis increases resistan [...]
glbN protein networkhttps://string-db.org/network/83332.Rv1542cHemoglobin GlbN; Binds oxygen cooperatively with very high affinity (P(50) = 0.013 mmHg at 20 degrees Celsius) because of a fast combination (25 microM(-1).s(-1)) and a slow dissociation (0.2 s(- [...]
Rv1543 protein networkhttps://string-db.org/network/83332.Rv1543Rv1543, (MTCY48.22c), len: 341 aa. Possible fatty-acyl CoA reductase, highly similar to P94129|U77680 fatty acyl-CoA reductase ACR1 from Acinetobacter calcoaceticus (295 aa), FASTA scores: opt: 8 [...]
Rv1544 protein networkhttps://string-db.org/network/83332.Rv1544Rv1544, (MTCY48.21), len: 267 aa. Possible ketoacyl reductase, highly similar to Z97179|MLCL383_26 putative oxidoreductase from Mycobacterium leprae (268 aa), FASTA score: (43.0% identity in 270 [...]
Rv1545 protein networkhttps://string-db.org/network/83332.Rv1545Hypothetical protein; Rv1545, (MTCY48.20), len: 75 aa. Hypothetical unknown protein.
Rv1546 protein networkhttps://string-db.org/network/83332.Rv1546Conserved protein; Rv1546, (MTCY48.19c), len: 143 aa. Conserved protein, similar to O05902|Rv0910|MTCY21C12.04 Hypothetical protein from Mycobacterium tuberculosis (144 aa), FASTA scores: E(): 5e [...]
dnaE1 protein networkhttps://string-db.org/network/83332.Rv1547Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. Thi [...]
PPE21 protein networkhttps://string-db.org/network/83332.Rv1548cRv1548c, (MTCY48.17), len: 678 aa. PPE21, Member of the Mycobacterium tuberculosis PPE family, similar to several e.g. YHS6_MYCTU|P42611 hypothetical 50.6 kDa protein in hsp65 3' region (517 aa), [...]
fadD11.1 protein networkhttps://string-db.org/network/83332.Rv1549Possible fatty-acid-CoA ligase FadD11.1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1549, (MTCY48.16c), len: 175 aa. Possible fadD11.1, fatty-acid-CoA synthetase, similar to the N-te [...]
fadD11 protein networkhttps://string-db.org/network/83332.Rv1550Rv1550, (MTCY48.15c), len: 571 aa. Probable fadD11,fatty-acid-CoA synthetase, similar, except in N-terminus,to many e.g. SC6A5.39|T35430 probable long-chain-fatty-acid--CoA ligase from Streptomyc [...]
plsB1 protein networkhttps://string-db.org/network/83332.Rv1551Rv1551, (MT1601, MTCY48.14c), len: 621 aa. Possible plsB1, acyltransferase, similar to PLSB_HAEIN|P44857 glycerol-3-phosphate acyltransferase from Haemophilus influenzae (810 aa), FASTA scores: o [...]
frdA protein networkhttps://string-db.org/network/83332.Rv1552Rv1552, (MTCY48.13c), len: 583 aa. Probable frdA,fumarate reductase, flavoprotein subunit, highly similar to others e.g. P00363|FRDA_ECOLI fumarate reductase flavoprotein subunit from Escherichia [...]
frdB protein networkhttps://string-db.org/network/83332.Rv1553Rv1553, (MTCY48.12c), len: 247 aa. Probable frdB,fumarate reductase, iron-sulfur subunit, highly similar to others e.g. P00364|FRDB_ECOLI fumarate reductase iron-sulfur protein from Escherichia c [...]
frdC protein networkhttps://string-db.org/network/83332.Rv1554Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.
frdD protein networkhttps://string-db.org/network/83332.Rv1555Fumarate reductase subunit D; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.
Rv1556 protein networkhttps://string-db.org/network/83332.Rv1556Rv1556, (MTCY48.09c), len: 202 aa. Possible regulatory protein, similar to X86780|SHGCPIR2|g987088 orfY, regulator of antibiotic transport complexes from Streptomyces hygroscopicus (204 aa), FAST [...]
mmpL6 protein networkhttps://string-db.org/network/83332.Rv1557Rv1557, (MTCY48.08c), len: 397 aa. Probable mmpL6,conserved transmembrane transport protein (see citations below). Member of RND superfamily, with strong similarity to C-terminal part of members [...]
Rv1558 protein networkhttps://string-db.org/network/83332.Rv1558Conserved protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent two-electron [...]
ilvA protein networkhttps://string-db.org/network/83332.Rv1559Probable threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine [...]
vapB11 protein networkhttps://string-db.org/network/83332.Rv1560Possible antitoxin VapB11; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin VapC11.
vapC11 protein networkhttps://string-db.org/network/83332.Rv1561Possible toxin VapC11; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase. Upon expression in E.coli and M.smegmatis inhibits translation, cell growth and colony formation [...]
treZ protein networkhttps://string-db.org/network/83332.Rv1562cMaltooligosyltrehalose trehalohydrolase TreZ; Is involved in the biosynthesis of trehalose but not in that of capsular glucan and glycogen.
treY protein networkhttps://string-db.org/network/83332.Rv1563cMaltooligosyltrehalose synthase TreY; Catalyzes the conversion of maltooligosaccharide into the non-reducing saccharide, maltooligosyl trehalose (alpha-maltooligosyl alpha-D-glucoside) by intramo [...]
treX protein networkhttps://string-db.org/network/83332.Rv1564cRv1564c, (MTCY48.01), len: 721 aa. Probable treX (previously called glgX), Maltooligosyltrehalose synthase. Strong similarity to D83245|g1890053 treX, glycogen debranching enzyme (glgX) from Sulf [...]
Rv1565c protein networkhttps://string-db.org/network/83332.Rv1565cRv1565c, (MTCY336.38), len: 729 aa. Conserved hypothetical membrane protein, some similarity to O05402 hypothetical 72.2 kDa protein from Bacillus subtilis (634 aa), FASTA results: opt: 384, E(): [...]
Rv1566c protein networkhttps://string-db.org/network/83332.Rv1566cPossible Inv protein; Rv1566c, (MTCY336.37), len: 230 aa. Possible inv protein, probably exported as has QQAPV repeats at C-terminus. Similar to Q49634 inv protein from Mycobacterium leprae (246 [...]
Rv1567c protein networkhttps://string-db.org/network/83332.Rv1567cRv1567c, (MTCY336.36), len: 94 aa. Probable membrane protein.
bioA protein networkhttps://string-db.org/network/83332.Rv1568Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA; Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KA [...]
bioF1 protein networkhttps://string-db.org/network/83332.Rv15698-amino-7-oxononanoate synthase 1; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], an [...]
bioD protein networkhttps://string-db.org/network/83332.Rv1570Dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form [...]
Rv1571 protein networkhttps://string-db.org/network/83332.Rv1571Conserved protein; Rv1571, (MTCY336.32c), len: 169 aa. Conserved protein, similar at N-terminal region to Q49625|LEPB1170_C3_227 hypothetical protein from Mycobacterium leprae (104 aa), FASTA res [...]
Rv1572c protein networkhttps://string-db.org/network/83332.Rv1572cConserved hypothetical protein; Rv1572c, (MTCY336.31B), len: 34 aa. Partial ORF,part of REP13E12 repeat element; 3' end of Rv1587c (MTCY336.17) after phage-like element (see citation below). Simi [...]
Rv1573 protein networkhttps://string-db.org/network/83332.Rv1573Rv1573, (MTCY336.31c), len: 136 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1574 protein networkhttps://string-db.org/network/83332.Rv1574Rv1574, (MTCY336.30), len: 103 aa. Probable phiRV1 phage related protein (see citation below); some similarity to N-terminus of Rv1575|MTCY441.17 Probable phiRV1 phage protein (166 aa), E(): 1.5e [...]
Rv1575 protein networkhttps://string-db.org/network/83332.Rv1575Rv1575, (MTCY336.29c), len: 166 aa. Probable phiRV1 phage protein (see citation below), showing similarity in N-terminal part to Rv1574|MTCY336.30c Probable phiRV1 phage protein (103 aa), FASTA s [...]
Rv1576c protein networkhttps://string-db.org/network/83332.Rv1576cRv1576c, (MTCY336.28), len: 473 aa. Probable phiRV1 phage protein (capsid subunit) (see citation below). Highly similar to hypothetical Mycobacterium tuberculosis protein Rv2650c|MTCY441.19 phiRV [...]
Rv1577c protein networkhttps://string-db.org/network/83332.Rv1577cRv1577c, (MTCY336.27), len: 170 aa. Probable phiRv1 phage protein (prohead protease) (see citation below). Highly similar to hypothetical protein Rv2651c|MTCY441.20c phiRV2 prohead protease, FAST [...]
Rv1578c protein networkhttps://string-db.org/network/83332.Rv1578cRv1578c, (MTCY336.26), len: 156 aa. Probable phiRv1 phage protein (terminase) (see citation below), highly similar to Rv2652c|MTCY441.21c phiRV2 phage protein from Mycobacterium tuberculosis, FAS [...]
Rv1579c protein networkhttps://string-db.org/network/83332.Rv1579cRv1579c, (MTCY336.25), len: 104 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1580c protein networkhttps://string-db.org/network/83332.Rv1580cRv1580c, (MTCY336.24), len: 90 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1581c protein networkhttps://string-db.org/network/83332.Rv1581cRv1581c, (MTCY336.23), len: 131 aa. Probable phiRv1 phage protein (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1582c protein networkhttps://string-db.org/network/83332.Rv1582cRv1582c, (MTCY336.22), len: 471 aa. Probable phiRv1 phage protein (see citation below). N-terminus is similar to C-terminus of Q38030 ORF9 Bacteriophage phi-C31 (519 aa), FASTA scores: opt: 331, [...]
Rv1583c protein networkhttps://string-db.org/network/83332.Rv1583cRv1583c, (MTCY336.21), len: 132 aa. Probable phiRv1 phage protein (see citation below), highly similar to Rv2656c|MTCY441.25c phiRV2 phage protein (130 aa), FASTA score: E(): 1.3e-33, (81.7% iden [...]
Rv1584c protein networkhttps://string-db.org/network/83332.Rv1584cRv1584c, (MTCY336.20), len: 73 aa. Possible phiRv1 phage protein (putative excisionase) (see citation below). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1585c protein networkhttps://string-db.org/network/83332.Rv1585cRv1585c, (MTCY336.19), len: 171 aa. Possible phage phiRv1 protein (see Hatfull 2000). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv1586c protein networkhttps://string-db.org/network/83332.Rv1586cProbable PhiRv1 integrase; Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriopha [...]
Rv1587c protein networkhttps://string-db.org/network/83332.Rv1587cRv1587c, (MTCY336.17), len: 333 aa. Partial REP13E12 repeat protein (see citation below), nearly identical (but has been interrupted by phiRv1 prophage) to Q50655|MTCY251.13c|Rv0094c hypothetical [...]
Rv1588c protein networkhttps://string-db.org/network/83332.Rv1588cRv1588c, (MTCY336.16), len: 222 aa. Partial REP13E12 repeat protein (see citation below), nearly identical to ORF's in other Rep13E12 repeats, including Rv0095c|MTCY251.14c|Y05E_MYCTU|Q10891 hypo [...]
bioB protein networkhttps://string-db.org/network/83332.Rv1589Probable biotin synthetase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Rv1590 protein networkhttps://string-db.org/network/83332.Rv1590Rv1590, (MTCY336.14c), len: 79 aa. Conserved hypothetical protein, similar to Q49616|LEPB1170_C1_162|YF90_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 368, E(): 1.7e-21,Smith-Water [...]
Rv1591 protein networkhttps://string-db.org/network/83332.Rv1591Rv1591, (MTCY336.13c), len: 221 aa. Probable transmembrane protein, similar to Q49626|LEPB1170_C3_229|YF91_MYCLE Hypothetical Mycobacterium leprae protein (198 aa), FASTA results: opt: 802, E(): [...]
Rv1592c protein networkhttps://string-db.org/network/83332.Rv1592cRv1592c, (MTCY336.12), len: 446 aa. Conserved hypothetical protein, some similarity to Q49629|B1170_F1_46 from Mycobacterium leprae (132 aa), FASTA results: opt: 332, E(): 4.5e-14, (56.3% identit [...]
Rv1593c protein networkhttps://string-db.org/network/83332.Rv1593cConserved protein; Rv1593c, (MTCY336.11), len: 236 aa. Conserved protein, highly similar to Q49628|B1170_F1_44 from Mycobacterium leprae (286 aa), FASTA scores: opt: 1304, E (): 0, (85.4% identit [...]
nadA protein networkhttps://string-db.org/network/83332.Rv1594Probable quinolinate synthetase NadA; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 2 subfam [...]
nadB protein networkhttps://string-db.org/network/83332.Rv1595Probable L-aspartate oxidase NadB; Catalyzes the oxidation of L-aspartate to iminoaspartate.
nadC protein networkhttps://string-db.org/network/83332.Rv1596Probable nicotinate-nucleotide pyrophosphatase NadC; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
Rv1597 protein networkhttps://string-db.org/network/83332.Rv1597Hypothetical protein; Rv1597, (MTCY336.07c), len: 252 aa. Hypothetical unknown protein.
Rv1598c protein networkhttps://string-db.org/network/83332.Rv1598cConserved protein; Rv1598c, (MTCY336.06), len: 136 aa. Conserved protein, some similarity to O06389|Rv0523c|MTCY25D10.02 from Mycobacterium tuberculosis (131 aa), FASTA scores: E(): 2.2e-09, (38. [...]
hisD protein networkhttps://string-db.org/network/83332.Rv1599Probable histidinol dehydrogenase HisD (HDH); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
hisC1 protein networkhttps://string-db.org/network/83332.Rv1600Rv1600, (MTCY336.04c), len: 380 aa. Probable hisC1,histidinol-phosphate aminotransferase O06591. Similar to many e.g. HIS8_STRCO|P16246 from Streptomyces coelicolor (369 aa), FASTA results: opt: [...]
hisB protein networkhttps://string-db.org/network/83332.Rv1601Rv1601, (MTCY336.03c), len: 210 aa. Probable hisB,imidazole glycerol-phosphate dehydratase. Similar to many e.g. HIS7_STRCO|P16247 from Streptomyces coelicolor (197 aa),FASTA results: opt: 763, E [...]
hisH protein networkhttps://string-db.org/network/83332.Rv1602Probable amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia a [...]
hisA protein networkhttps://string-db.org/network/83332.Rv1603Probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
impA protein networkhttps://string-db.org/network/83332.Rv1604Probable inositol-monophosphatase ImpA (imp); Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria.
hisF protein networkhttps://string-db.org/network/83332.Rv1605Probable cyclase HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR [...]
hisI protein networkhttps://string-db.org/network/83332.Rv1606Probable phosphoribosyl-AMP 1,6 cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
chaA protein networkhttps://string-db.org/network/83332.Rv1607Rv1607, (MTV046.05), len: 360 aa. Probable chaA,ionic transporter integral membrane protein, putative calcium/proton antiporter, similar to many e.g. P31801|CHAA_ECOLI calcium/proton antiporter f [...]
bcpB protein networkhttps://string-db.org/network/83332.Rv1608cProbable peroxidoxin BcpB; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protect [...]
trpE protein networkhttps://string-db.org/network/83332.Rv1609Anthranilate synthase component I TrpE (glutamine amidotransferase); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthe [...]
Rv1610 protein networkhttps://string-db.org/network/83332.Rv1610Rv1610, (MTCY01B2.02), len: 235 aa. Possible conserved membrane protein. Equivalent to AL049913|MLCB1610_23 hypothetical protein from Mycobacterium leprae (264 aa), FASTA score: (65.8% identity i [...]
trpC protein networkhttps://string-db.org/network/83332.Rv1611Rv1611, (MTCY01B2.03), len: 272 aa. Probable trpC,indole-3-glycerol phosphate synthase. Similar to Q55508|SLR0546 hypothetical 33.0 kDa protein from synechocystis SP (295 aa), FASTA score: opt: 2 [...]
trpB protein networkhttps://string-db.org/network/83332.Rv1612Tryptophan synthase, beta subunit TrpB; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
trpA protein networkhttps://string-db.org/network/83332.Rv1613Probable tryptophan synthase, alpha subunit TrpA; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
lgt protein networkhttps://string-db.org/network/83332.Rv1614Possible prolipoprotein diacylglyceryl transferases Lgt; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a proli [...]
Rv1615 protein networkhttps://string-db.org/network/83332.Rv1615Probable membrane protein; Rv1615, (MTCY01B2.07), len: 146 aa. Probable membrane protein.
Rv1616 protein networkhttps://string-db.org/network/83332.Rv1616Conserved membrane protein; Rv1616, (MTCY01B2.08), len: 132 aa. Conserved membrane protein, with some similarity to other hypothetical proteins e.g. AL096884|SC4G6_9 from Streptomyces coelicolor [...]
pykA protein networkhttps://string-db.org/network/83332.Rv1617Rv1617, (MTCY01B2.09), len: 472 aa. Probable pykA,pyruvate kinase. FASTA best: Q46078 pyruvate kinase from corynebacterium glutamicum (475 aa), opt: 2221, E(): 0,(72.2% identity in 468 aa overlap [...]
tesB1 protein networkhttps://string-db.org/network/83332.Rv1618Rv1618, (MTCY01B2.10), len: 300 aa. Probable tesB1,acyl-CoA thioesterase II, similar to other acyl-CoA thioesterases e.g. TESB_ECOLI|P23911 acyl-CoA thioesterase II from Escherichia coli (285 aa) [...]
Rv1619 protein networkhttps://string-db.org/network/83332.Rv1619Conserved membrane protein; Rv1619, (MTCY01B2.11), len: 484 aa. Conserved membrane protein. Some similarity to N-terminus of P94974|Rv1640c|MTCY06H11.04c probable lysyl-tRNA synthetase 2 from Myc [...]
cydC protein networkhttps://string-db.org/network/83332.Rv1620cRv1620c, (MTCY01B2.12c), len: 576 aa. Probable cydC,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below [...]
cydD protein networkhttps://string-db.org/network/83332.Rv1621cRv1621c, (MTCY01B2.13c), len: 527 aa. Probable cydD,transmembrane ATP-binding protein ABC transporter involved in transport of component linked with the assembly of cytochrome (see citation below [...]
cydB protein networkhttps://string-db.org/network/83332.Rv1622cRv1622c, (MTCY01B2.14c), len: 346 aa. Probable cydB,cytochrome D ubiquinol oxidase subunit II, integral membrane protein, similar to others e.g. P11027|CYDB_ECOLI cytochrome D ubiquinol oxidase s [...]
cydA protein networkhttps://string-db.org/network/83332.Rv1623cIntegral membrane cytochrome D ubiquinol oxidase CydA; Rv1623c, (MTCY01B2.15c), len: 485 aa. Probable cydA (previously known as appC, but renamed cydA to conform with Mycobacterium smegmatis nome [...]
Rv1624c protein networkhttps://string-db.org/network/83332.Rv1624cRv1624c, (MTCY01B2.16c), len: 195 aa. Probable membrane protein, first start taken. Some similarity to Rv3155 nuoK, NADH dehydrogenase chain K from M. tuberculosis. Also similar to AAK72093.1|AF1 [...]
cya protein networkhttps://string-db.org/network/83332.Rv1625cRv1625c, (MT1661, MTCY01B2.17c), len: 443 aa. Cya,membrane-anchored adenylyl cyclase (see citations below). C-terminal half is similar to region in numerous eukaryotic adenylate and guanylate cyc [...]
pdtaR protein networkhttps://string-db.org/network/83332.Rv1626Probable two-component system transcriptional regulator; Member of the two-component regulatory system PdtaR/PdtaS.
Rv1627c protein networkhttps://string-db.org/network/83332.Rv1627cRv1627c, (MTCY01B2.19c), len: 402 aa. Probable nonspecific lipid-transfer protein, similar to many lipid carrier proteins e.g. Q51797 acetyl CoA synthase from Pyrococcus furiosus (388 aa), FASTA [...]
Rv1628c protein networkhttps://string-db.org/network/83332.Rv1628cConserved protein; Rv1628c, (MTCY01B2.20c), len: 163 aa. Conserved protein, some similarity to others e.g. Q51796 ACAC protein in Pyrococcus furiosus (136 aa), FASTA scores: opt: 199,E(): 4.6e-06 [...]
polA protein networkhttps://string-db.org/network/83332.Rv1629Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
rpsA protein networkhttps://string-db.org/network/83332.Rv163030S ribosomal protein S1 RpsA; Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-transl [...]
coaE protein networkhttps://string-db.org/network/83332.Rv1631Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A. Can also use dATP, with lower ef [...]
Rv1632c protein networkhttps://string-db.org/network/83332.Rv1632cHypothetical protein; Rv1632c, (MTCY01B2.24c), len: 147 aa. Hypothetical unknown protein.
uvrB protein networkhttps://string-db.org/network/83332.Rv1633Probable excinuclease ABC (subunit B-helicase) UvrB; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB s [...]
Rv1634 protein networkhttps://string-db.org/network/83332.Rv1634Possible drug efflux membrane protein; Could be involved in fluoroquinolones efflux. Belongs to the major facilitator superfamily.
Rv1635c protein networkhttps://string-db.org/network/83332.Rv1635cProbable mannosyltransferase. Probable conserved transmembrane protein; Rv1635c, (MTCY01B2.27c), len: 556 aa. Probable mannosyltransferase (See Dinadayala et al., 2006). Predicted to be in the GT [...]
TB15.3 protein networkhttps://string-db.org/network/83332.Rv1636Rv1636, (MTCY01B2.28), len: 146 aa. TB15.3,iron-regulated universal stress protein family protein (see citations below), similar to other hypothetical proteins from diverse organisms e.g. Q57951| [...]
Rv1637c protein networkhttps://string-db.org/network/83332.Rv1637cConserved protein; Rv1637c, (MTCY01B2.29c,MTCY06H11.01c), len: 264 aa. Conserved protein, some similarity to others e.g. P05446|GLO2_RHOBL probable hydroxyacylglutathione hydrolase (255 aa), FAST [...]
uvrA protein networkhttps://string-db.org/network/83332.Rv1638Probable excinuclease ABC (subunit A-DNA-binding ATPase) UvrA; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A dam [...]
Rv1638A protein networkhttps://string-db.org/network/83332.Rv1638ARv1638A, len: 85 aa. Conserved hypothetical protein,similar to C-terminal part of P31511|35KD_MYCTU 35kd immunogenic protein from Mycobacterium tuberculosis (270 aa), FASTA scores: opt: 159, E(): [...]
Rv1639c protein networkhttps://string-db.org/network/83332.Rv1639cRv1639c, (MTCY06H11.03c), len: 489 aa. Conserved hypothetical membrane protein. Some similarity to P35866|YLI2_CORGL Hypothetical 45.7 kDa protein from Corynebacterium glutamicum (426 aa), FASTA [...]
lysX protein networkhttps://string-db.org/network/83332.Rv1640cLysyl-tRNA synthetase 2 LysX; Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which pro [...]
infC protein networkhttps://string-db.org/network/83332.Rv1641Probable initiation factor if-3 InfC; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus en [...]
rpmI protein networkhttps://string-db.org/network/83332.Rv1642Rv1642, (MTCY06H11.06), len: 64 aa. rpmI, 50S ribosomal protein L35, similar to several e.g. RL35_SYNY3|P48959 from Synechocystis sp. (67 aa), fasta scores: opt: 179, E(): 2.7e-08, (51.6% identit [...]
rplT protein networkhttps://string-db.org/network/83332.Rv164350S ribosomal protein L20 RplT; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing [...]
tsnR protein networkhttps://string-db.org/network/83332.Rv1644Rv1644, (MTCY06H11.08), len: 260 aa. Possible tsnR,23S rRNA methyltransferase, similar to several e.g. TSNR_STRLU|P52393 from Streptomyces laurentii (270 aa),FASTA scores: opt: 276, E(): 3.6e-11, [...]
Rv1645c protein networkhttps://string-db.org/network/83332.Rv1645cConserved hypothetical protein; Rv1645c, (MTCY06H11.10c), len: 351 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis hypothetical proteins e.g. O53837|Rv0826|MTV043. [...]
PE17 protein networkhttps://string-db.org/network/83332.Rv1646Rv1646, (MTCY06H11.11), len: 310 aa. PE17, Member of the Mycobacterium tuberculosis PE family of proteins (see citation below), similar to many e.g. YW36_MYCTU|Q10873 hypothetical 53.7 kd protein [...]
Rv1647 protein networkhttps://string-db.org/network/83332.Rv1647Adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase); Rv1647, (MTCY06H11.12), len: 316 aa. Adenylate cyclase, some similarity to other Mycobacterium tuberculosis proteins e.g. Q11055|Rv [...]
Rv1648 protein networkhttps://string-db.org/network/83332.Rv1648Rv1648, (MTCY06H11.13), len: 268 aa. Probable transmembrane protein, some similarity to Rv3434c|MTCY77.06C (237 aa), FASTA scores: E(): 0.00039,(31.4% identity in 194 aa overlap).
pheS protein networkhttps://string-db.org/network/83332.Rv1649Rv1649, (MTCY06H11.14), len: 341 aa. Probable pheS,Phenylalanyl-tRNA synthetase alpha chain, similar to several e.g. SYFA_ECOLI|P08312 from Escherichia coli (327 aa), FASTA scores: opt: 978, E(): [...]
pheT protein networkhttps://string-db.org/network/83332.Rv1650Rv1650, (MTCY06H11.15), len: 831 aa. Probable pheT,Phenylalanyl-tRNA synthetase beta chain, similar to several e.g. SYFB_ECOLI|P07395 from Escherichia coli (795 aa),FASTA scores: opt: 995, E(): 0 [...]
PE_PGRS30 protein networkhttps://string-db.org/network/83332.Rv1651cPE-PGRS family protein PE_PGRS30; Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response. Required for full virulence. Involved in inhibit [...]
argC protein networkhttps://string-db.org/network/83332.Rv1652Probable N-acetyl-gamma-glutamyl-phoshate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
argJ protein networkhttps://string-db.org/network/83332.Rv1653Probable glutamate N-acetyltransferase ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acet [...]
argB protein networkhttps://string-db.org/network/83332.Rv1654Probable acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate.
argD protein networkhttps://string-db.org/network/83332.Rv1655Rv1655, (MTCY06H11.20), len: 400 aa. Probable argD,Acetylornithine aminotransferase, similar to ARGD_ECOLI|P18335 (406 aa), FASTA scores: opt: 958, E(): 0,(38.6% identity in 404 aa overlap), cont [...]
argF protein networkhttps://string-db.org/network/83332.Rv1656Probable ornithine carbamoyltransferase, anabolic ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce [...]
argR protein networkhttps://string-db.org/network/83332.Rv1657Probable arginine repressor ArgR (AHRC); Regulates arginine biosynthesis genes.
argG protein networkhttps://string-db.org/network/83332.Rv1658Rv1658, (MTCY06H11.23), len: 398 aa. Probable argG,Argininosuccinate synthase, similar to ASSY_STRCL|P50986 argininosuccinate synthase from Streptomyces clavuligerus (397 aa), FASTA scores: opt: [...]
argH protein networkhttps://string-db.org/network/83332.Rv1659Rv1659, (MTCY06H11.24), len: 470 aa. Probable argH,Argininosuccinate lyase, similar to ARLY_ECOLI|P11447 argininosuccinate lyase from Escherichia coli (457 aa),FASTA scores: opt: 1091, E(): 0, (4 [...]
pks10 protein networkhttps://string-db.org/network/83332.Rv1660Chalcone synthase Pks10; Could catalyze the elongation of hydroxybenzoyl-CoA as well as elongation of the aliphatic precursor involved in the synthesis of phthiocerol dimycocerosate (DIM); Belong [...]
pks7 protein networkhttps://string-db.org/network/83332.Rv1661Rv1661, (MTCY06H11.26), len: 2126 aa. Probable pks7,polyketide synthase, similar to many e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa), FASTA scores: E(): 0, (48.8% ide [...]
pks8 protein networkhttps://string-db.org/network/83332.Rv1662Rv1662, (MTCY275.01-MTCY06H11.27), len: 1602 aa. Probable pks8, polyketide synthase, similar to many polyketide synthases e.g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 from Sacch [...]
pks17 protein networkhttps://string-db.org/network/83332.Rv1663Rv1663, (MTCY275.02), len: 502 aa. Probable pks17,polyketide synthase, similar to other polyketide synthases e g. ERY2_SACER|Q03132 erythronolide synthase, modules 3 and 4 (3567 aa) from Saccharo [...]
pks9 protein networkhttps://string-db.org/network/83332.Rv1664Rv1664, (MTCY275.03), len: 1017 aa. Probable pks9,polyketide synthase, similar to OL56_STRAT|Q07017 oleandomycin polyketide synthase, modules 5 and 6 from Streptomyces antibioticus (3519 aa), FAS [...]
pks11 protein networkhttps://string-db.org/network/83332.Rv1665Chalcone synthase Pks11; Involved in the biosynthesis of tri- and tetraketide alpha- pyrones. Pks11 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malony [...]
cyp139 protein networkhttps://string-db.org/network/83332.Rv1666cRv1666c, (MT1706, MTV047.02c), len: 430 aa. Probable cyp139, cytochrome P450, similar to many e.g. U38537|APU38537_7 from Anabaena sp. (459 aa), FASTA scores: opt: 516, E(): 1.7e-26, (25.8% ident [...]
Rv1667c protein networkhttps://string-db.org/network/83332.Rv1667cRv1667c, (MTV047.03c), len: 217 aa. Probable second part of macrolide-transport ATP-binding protein ABC transporter (see citation below), with similarity to C-terminal end of putative ABC transpo [...]
Rv1668c protein networkhttps://string-db.org/network/83332.Rv1668cRv1668c, (MTV047.04c), len: 372 aa. Probable first part of macrolide-transport ATP-binding protein ABC transporter (see citation below), similar to many ATP-binding proteins ABC transporter e.g. [...]
Rv1669 protein networkhttps://string-db.org/network/83332.Rv1669Hypothetical protein; Rv1669, (MTV047.04B), len: 120 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al., 2008).
Rv1670 protein networkhttps://string-db.org/network/83332.Rv1670Rv1670, (MTV047.05), len: 115 aa. Conserved hypothetical protein, highly similar to D90908|D90908_87 Hypothetical protein of Synechocystis sp. PCC6803 complete (94 aa), FASTA scores opt: 378, E() [...]
Rv1671 protein networkhttps://string-db.org/network/83332.Rv1671Probable membrane protein; Rv1671, (MTV047.06), len: 130 aa. Probable membrane protein. Weak similarity to mercuric transport proteins.
Rv1672c protein networkhttps://string-db.org/network/83332.Rv1672cRv1672c, (MTV047.07c), len: 443 aa. Probable conserved integral membrane transport protein, major facilitator superfamily, similar to several phthalate transporters or tartrate transporters e.g. [...]
Rv1673c protein networkhttps://string-db.org/network/83332.Rv1673cRv1673c, (MTV047.08c), len: 310 aa. Conserved hypothetical protein, shows weak similarity to P44103|YA48_HAEIN Hypothetical protein HI10 48 precursor (369 aa), FASTA scores: E(): 8.3e-11, (26.1% [...]
Rv1674c protein networkhttps://string-db.org/network/83332.Rv1674cRv1674c, (MTV047.09c), len: 218 aa. Probable transcriptional regulatory protein. Highly similar to AJ005575|SPE005575_2 Streptomyces peucetius (226 aa), FASTA scores: opt: 662, E(): 0, (50.0% ide [...]
cmr protein networkhttps://string-db.org/network/83332.Rv1675cProbable transcriptional regulatory protein Cmr; Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro.
Rv1676 protein networkhttps://string-db.org/network/83332.Rv1676Unknown protein; Rv1676, (MTV047.11), len: 234 aa. Unknown protein.
dsbF protein networkhttps://string-db.org/network/83332.Rv1677Rv1677, (MTV047.12), len: 182 aa. Probable dsbF,conserved lipoprotein possibly involved in thiol:disulfide interchange. Highly similar to C-terminus of Z74024|MTCY274.09 mpt53 soluble secreted an [...]
Rv1678 protein networkhttps://string-db.org/network/83332.Rv1678Rv1678, (MTV047.13), len: 300 aa. Probable integral membrane protein.
fadE16 protein networkhttps://string-db.org/network/83332.Rv1679Rv1679, (MTV047.14, MTCI125.01), len: 373 aa. Possible fadE16, acyl-CoA dehydrogenase, similar to acyl/butyryl-CoA dehydrogenases e.g. NP_244665.1|NC_002570 acyl-CoA dehydrogenase from Bacillus h [...]
Rv1680 protein networkhttps://string-db.org/network/83332.Rv1680Hypothetical protein; Rv1680, (MTCI125.02), len: 274 aa. Hypothetical unknown protein.
moeX protein networkhttps://string-db.org/network/83332.Rv1681Rv1681, (MTCI125.03), len: 330 aa. Possible moeX,Molybdopterin biosynthesis protein, has weak similarity to MOAA_ECOLI|P30745 molybdenum cofactor biosynthesis protein (329 aa), FASTA scores: opt: [...]
Rv1682 protein networkhttps://string-db.org/network/83332.Rv1682Rv1682, (MTCI125.04), len: 305 aa. Probable coiled-coil structural protein, weakly similar to many paramyosins, kinesins and plectins e.g. MYSP_ONCVO|Q02171 paramyosin from onchocerca volvulus (8 [...]
Rv1683 protein networkhttps://string-db.org/network/83332.Rv1683Rv1683, (MTCI125.05), len: 999 aa. Possible bifunctional long-chain acyl-CoA synthase and lipase. Equivalent to Z95117|MLCB1351_21 possible long-chain acyl-CoA synthase from Mycobacterium leprae [...]
Rv1684 protein networkhttps://string-db.org/network/83332.Rv1684Rv1684, (MTCI125.06), len: 74 aa. Conserved hypothetical protein, similar to P75844|YCAR_ECOLI Protein YCAR from Escherichia coli (60 aa), FASTA scores: opt: 108,E(): 0.00022, (39.0% identity in [...]
Rv1685c protein networkhttps://string-db.org/network/83332.Rv1685cRv1685c, (MTCI125.07c), len: 207 aa. Conserved hypothetical protein, some similarity to other Mycobacterium tuberculosis hypothetical regulatory proteins e.g. Q10774|Rv1556|YF56_MYCTU (202 aa), F [...]
Rv1686c protein networkhttps://string-db.org/network/83332.Rv1686cRv1686c, (MTCI125.08c), len: 226 aa. Probable conserved integral membrane protein ABC transporter (see citation below), similar to AL049819|SCE7.05 putative integral membrane protein from Strepto [...]
Rv1687c protein networkhttps://string-db.org/network/83332.Rv1687cRv1687c, (MTCI125.09c), len: 255 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), similar to many ABC-type transporters e.g. P55476|NODI_RHISN nodulation ATP-bindi [...]
mpg protein networkhttps://string-db.org/network/83332.Rv1688Rv1688, (MTCI125.10), len: 203 aa. Possible mpg,3-methyladenine DNA glycosylase (see citation below),similar to several eukaryotic 3-methylpurine DNA glycosylases and 3-methyladenine DNA glycosyl [...]
tyrS protein networkhttps://string-db.org/network/83332.Rv1689Probable tyrosyl-tRNA synthase TyrS (TYRRS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to [...]
lprJ protein networkhttps://string-db.org/network/83332.Rv1690Probable lipoprotein LprJ; Overexpression induces expression of sensor protein kdpD gene at low K(+) concentrations (0 and 250 uM, tested in M.smegatis).
Rv1691 protein networkhttps://string-db.org/network/83332.Rv1691Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-2 [...]
Rv1692 protein networkhttps://string-db.org/network/83332.Rv1692Probable phosphatase; Glycerol-phosphate phosphatase with a preference for D- glycerol 3-phosphate (sn-glycerol 1-phosphate) over L-glycerol 3- phosphate (sn-glycerol 3-phosphate). Is the final e [...]
Rv1693 protein networkhttps://string-db.org/network/83332.Rv1693Rv1693, (MTCI125.15), len: 58 aa. Conserved hypothetical protein, shows some similarity to AL583921 hypothetical protein from Mycobacterium leprae (61 aa). Probable coiled-coil from aa 30 to 58. [...]
tlyA protein networkhttps://string-db.org/network/83332.Rv16942'-O-methyltransferase TlyA; Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protect [...]
ppnK protein networkhttps://string-db.org/network/83332.Rv1695Inorganic polyphosphate/ATP-NAD kinase PpnK (poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Cat [...]
recN protein networkhttps://string-db.org/network/83332.Rv1696Probable DNA repair protein RecN (recombination protein N); May be involved in recombinational repair of damaged DNA.
Rv1697 protein networkhttps://string-db.org/network/83332.Rv1697Rv1697, (MTCI125.19), len: 393 aa. Conserved hypothetical protein, highly similar to Q49895|MLC1351.11C|U00021 Hypothetical protein of Mycobacterium leprae from cosmid L247 (430 aa), FASTA scores [...]
mctB protein networkhttps://string-db.org/network/83332.Rv1698Outer membrane protein MctB; Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper c [...]
pyrG protein networkhttps://string-db.org/network/83332.Rv1699Probable CTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Is essential for M.tuberculosis growth in vitro and e [...]
Rv1700 protein networkhttps://string-db.org/network/83332.Rv1700NUDIX hydrolase; Rv1700, (MTCI125.22), len: 207 aa. Nudix hydrolase,equivalent to Q49891|MLC1351.08C|Z95117 Hypothetical protein from Mycobacterium leprae (177 aa), FASTA scores: (66.7% identity [...]
xerD protein networkhttps://string-db.org/network/83332.Rv1701Probable integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to con [...]
Rv1702c protein networkhttps://string-db.org/network/83332.Rv1702cRv1702c, (MTCI125.24c), len: 454 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q5 [...]
Rv1703c protein networkhttps://string-db.org/network/83332.Rv1703cRv1703c, (MTCI125.25c), len: 196 aa. Probable catechol-o-methyltransferase, most similar to COMT_HUMAN|P21964 soluble form of mammalian catechol o-methyltransferase (271 aa), FASTA scores: opt: 4 [...]
cycA protein networkhttps://string-db.org/network/83332.Rv1704cRv1704c, (MTCI125.26c), len: 556 aa. Probable cycA,D-serine/D-alanine/glycine transporter, highly similar to P39312|CYCA_ECOLI d-serine/d-alanine/glycine transporter from Escherichia coli (470 aa [...]
PPE22 protein networkhttps://string-db.org/network/83332.Rv1705cRv1705c, (MTCI125.27c), len: 385 aa. PPE22, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy27 [...]
Rv1706A protein networkhttps://string-db.org/network/83332.Rv1706ARv1706A, len: 55 aa. Conserved hypothetical protein,similar to part of several probable export proteins e.g. Rv0783c|Z80226_28 from Mycobacterium tuberculosis (540 aa),FASTA scores: opt: 125, E() [...]
PPE23 protein networkhttps://string-db.org/network/83332.Rv1706cRv1706c, (MTCI125.28c), len: 394 aa. PPE23, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. YX23_MYCTU|Q10813 hypothetical 41.1 kDa protein cy27 [...]
Rv1707 protein networkhttps://string-db.org/network/83332.Rv1707Rv1707, (MTCI125.29), len: 486 aa. Probable conserved transmembrane protein, possibly involved in transport of sulfate, similar to several hypothetical proteins belonging to the sulfate permease [...]
Rv1708 protein networkhttps://string-db.org/network/83332.Rv1708Putative initiation inhibitor protein; May play a role in septum formation.
scpA protein networkhttps://string-db.org/network/83332.Rv1709Possible segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that [...]
scpB protein networkhttps://string-db.org/network/83332.Rv1710Possible segregation and condensation protein ScpB; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that [...]
Rv1711 protein networkhttps://string-db.org/network/83332.Rv1711Rv1711, (MTCI125.33), len: 254 aa. Conserved hypothetical protein, highly similar to a large family of hypothetical proteins e.g. P37765|YCIL_ECOLI from Escherichia coli (291 aa), FASTA scores: o [...]
cmk protein networkhttps://string-db.org/network/83332.Rv1712Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck); Rv1712, (MTCI125.34), len: 230 aa. cmk, cytidylate kinase, highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase [...]
engA protein networkhttps://string-db.org/network/83332.Rv1713Probable GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Eng [...]
Rv1714 protein networkhttps://string-db.org/network/83332.Rv1714Rv1714, (MTV048.01), len: 270 aa. Probable oxidoreductase similar to many e.g. AE0010|AE001021_4 Archaeoglobus fulgidus section 79 (281 aa), FASTA scores: opt: 578, E(): 3.3e-31, (38.9% identity [...]
fadB3 protein networkhttps://string-db.org/network/83332.Rv1715Rv1715, (MTV048.02), len: 304 aa. Probable fadB3,3-hydroxybutyryl-CoA dehydrogenase, highly similar to many e.g. NP_107236.1|NC_002678 3-hydroxybutyryl-CoA dehydrogenase from Mesorhizobium loti ( [...]
Rv1716 protein networkhttps://string-db.org/network/83332.Rv1716Conserved hypothetical protein; Rv1716, (MTV048.03,MTCY04C12.01), len: 276 aa. Conserved hypothetical protein, shows high similarity with AF1200|O29068|AE001021_11A conserved protein of Archaeogl [...]
Rv1717 protein networkhttps://string-db.org/network/83332.Rv1717Rv1717, (MTCY04C12.02), len: 116 aa. Conserved hypothetical protein, similar to O29060|AF1208|AE001021 Hypothetical protein from Arecheoglobus fulgidus (114 aa),FASTA scores: opt: 254, E(): 3.3e- [...]
Rv1718 protein networkhttps://string-db.org/network/83332.Rv1718Rv1718, (MTCY04C12.03), len: 272 aa. Conserved hypothetical protein, similar to O29058|AF1210|AE001021 Hypothetical protein from Archeoglobus (313 aa), FASTA scores: opt: 301, E(): 8e-23, (31.6% [...]
Rv1719 protein networkhttps://string-db.org/network/83332.Rv1719Rv1719, (MTCY04C12.04), len: 259 aa. Probable transcriptional regulatory protein, similar to YIAJ_ECOLI|P37671 hypothetical transcriptional regulator from Escherichia coli (282 aa), FASTA scores: [...]
vapC12 protein networkhttps://string-db.org/network/83332.Rv1720cPossible toxin VapC12; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB12 (By similarity). Belongs to the PINc/VapC protein family.
vapB12 protein networkhttps://string-db.org/network/83332.Rv1721cPossible antitoxin VapB12; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC12.
Rv1722 protein networkhttps://string-db.org/network/83332.Rv1722Possible carboxylase; Rv1722, (MTCY04C12.07), len: 494 aa. Possible carboxylases. Weak similarity to several e.g. ACCC_BACSU|P49787 biotin carboxylase from Bacillus subtilis (448 aa), fasta score [...]
Rv1723 protein networkhttps://string-db.org/network/83332.Rv1723Probable hydrolase; Rv1723, (MTCY04C12.08), len: 415 aa. Possible hydrolase, similar to others e.g. NYLB_FLASP|P07061 6-aminohexanoate-dimer hydrolase from Flavobacterium sp. (392 aa), FASTA scor [...]
Rv1724c protein networkhttps://string-db.org/network/83332.Rv1724cHypothetical protein; Rv1724c, (MTCY04C12.09c), len: 139 aa. Hypothetical unknown protein.
Rv1725c protein networkhttps://string-db.org/network/83332.Rv1725cConserved hypothetical protein; Rv1725c, (MTCY04C12.10c), len: 236 aa. Conserved hypothetical protein, similar to other hypothetical proteins from diverse organisms e.g. P70885|U44893 ORF108 from [...]
Rv1726 protein networkhttps://string-db.org/network/83332.Rv1726Rv1726, (MTCY04C12.11), len: 461 aa. Probable oxidoreductase, similar to HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 678, E(): 0, (29.5% identity in 465 aa overlap [...]
Rv1727 protein networkhttps://string-db.org/network/83332.Rv1727Rv1727, (MTCY04C12.12), len: 189 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical proteins P72040|Rv3773c|MTCY13D12.07C (194 aa), FASTA scores: opt: 176, E() [...]
Rv1728c protein networkhttps://string-db.org/network/83332.Rv1728cConserved hypothetical protein; Rv1728c, (MTCY04C12.13c), len: 256 aa. Conserved hypothetical protein, some similarity to O07246|Rv0320|MTCY63.25 possible exported protein from Mycobacterium tube [...]
Rv1729c protein networkhttps://string-db.org/network/83332.Rv1729cPossible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv1730c protein networkhttps://string-db.org/network/83332.Rv1730cRv1730c, (MTCY04C12.15c), len: 517 aa. Possible penicillin-binding protein, similar to others e.g. PBP4_NOCLA|Q06317 penicillin-binding protein 4 (pbp-4) from Nocardia lactamdurans (381 aa), FAST [...]
gabD2 protein networkhttps://string-db.org/network/83332.Rv1731Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2; Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. Although it has succinate semialdeh [...]
Rv1732c protein networkhttps://string-db.org/network/83332.Rv1732cConserved protein; Rv1732c, (MTCY04C12.17c), len: 182 aa. Conserved protein, highly similar to hypothetical proteins from several organisms e.g. P73178|SLL1289|D90904 from Synechocystis (194 aa), [...]
Rv1733c protein networkhttps://string-db.org/network/83332.Rv1733cRv1733c, (MTCY04C12.18c), len: 210 aa. Probable conserved transmembrane protein. Similar to AL109962|SCJ1_26 hypothetical protein from Streptomyces coelicolor (193 aa), FASTA scores: opt: 287, E( [...]
Rv1734c protein networkhttps://string-db.org/network/83332.Rv1734cRv1734c, (MTCY04C12.19c), len: 80 aa. Conserved hypothetical protein, similar to C-terminal region Q9Z8N2|CP0452|AE001615 Dihydrolipoamide Acetyltransferase from Chlamydia pneumoniae (429 aa), FA [...]
Rv1735c protein networkhttps://string-db.org/network/83332.Rv1735cHypothetical membrane protein; Rv1735c, (MTCY04C12.20c), len: 165 aa. Hypothetical membrane protein, similar to part of O58614|PH0884|AP000004 Hypothetical malic acid transport protein from Pyroc [...]
narX protein networkhttps://string-db.org/network/83332.Rv1736cProbable nitrate reductase NarX; Does not seem to have nitrate reductase activity. In the N-terminal section; belongs to the nitrate reductase alpha subunit family. In the C-terminal section; bel [...]
narK2 protein networkhttps://string-db.org/network/83332.Rv1737cPossible nitrate/nitrite transporter NarK2; Permits nitrate and nitrate transport into E.coli. Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
Rv1738 protein networkhttps://string-db.org/network/83332.Rv1738Conserved protein; Rv1738, (MTCY04C12.23), len: 94 aa. Conserved protein, similar to P71931|Rv2632c|YQ32_MYCTU Hypothetical 10.1 kDa protein from Mycobacterium tuberculosis (93 aa),FASTA scores: [...]
Rv1739c protein networkhttps://string-db.org/network/83332.Rv1739cProbable sulphate-transport transmembrane protein ABC transporter; Expression in E.coli induces sulfate uptake during early- to mid-log phase growth. Uptake is maximal at pH 6.0, is sulfate-speci [...]
vapB34 protein networkhttps://string-db.org/network/83332.Rv1740Possible antitoxin VapB34; Antitoxin component of a possible type II toxin-antitoxin (TA) system. The cognate toxin is VapC34.
vapC34 protein networkhttps://string-db.org/network/83332.Rv1741Possible toxin VapC34. Contains PIN domain; Toxic component of a possible type II toxin-antitoxin (TA) system. A putative RNase. Its cognate antitoxin is VapB34 (By similarity).; Belongs to the P [...]
Rv1742 protein networkhttps://string-db.org/network/83332.Rv1742Unknown protein; Rv1742, (MTCY28.04,MTCY04C12.27), len: 245 aa. Unknown protein.
pknE protein networkhttps://string-db.org/network/83332.Rv1743Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E); Important for survival of the bacterium in the host during infection. Promotes the survival of infected [...]
Rv1744c protein networkhttps://string-db.org/network/83332.Rv1744cProbable membrane protein; Rv1744c, (MTCY28.06c), len: 133 aa. Probable membrane protein, contains four imperfect 10 aa repeats,some similarity to Q25946 (MSA-2) (fragment) from Plasmodium falcip [...]
idi protein networkhttps://string-db.org/network/83332.Rv1745cIsopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphospha [...]
pknF protein networkhttps://string-db.org/network/83332.Rv1746Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F); Phosphorylates the FHA domains of the ABC transporter Rv1747, the heat-shock protein GroEL 1, and Rv0020c. May [...]
Rv1747 protein networkhttps://string-db.org/network/83332.Rv1747Probable conserved transmembrane ATP-binding protein ABC transporter; Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the mem [...]
Rv1748 protein networkhttps://string-db.org/network/83332.Rv1748Unknown protein; Rv1748, (MTCY28.11, MTCY04C12.32), len: 243 aa. Unknown protein. Possibly exported protein, hydrophobic domain, TM helix aa 23-45.
Rv1749c protein networkhttps://string-db.org/network/83332.Rv1749cRv1749c, (MTCY28.12c-MTCY04C12.33c), len: 185 aa. Possible integral membrane protein, similar to O27914|AE000940 hypothetical protein MTH1892 from Methanobacterium thermoautotrophicum (168 aa), f [...]
fadD1 protein networkhttps://string-db.org/network/83332.Rv1750cPossible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv1750c, (MTCY28.13c, MTCY04C12.34), len: 532 aa. Possible fadD1, fatty-acid-CoA synthetase, similar in [...]
Rv1751 protein networkhttps://string-db.org/network/83332.Rv1751Probable oxidoreductase; Rv1751, (MTCY28.14-MTCY04C12.35), len: 460 aa. Probable oxidoreductase, possibly a monooxygenase or hydroxylase, similar to MHPA_ECOLI|P77397 3-(3-hydroxy-phenyl) propion [...]
Rv1752 protein networkhttps://string-db.org/network/83332.Rv1752Rv1752, (MTCY28.15), len: 149 aa. Conserved hypothetical protein, similar to C-terminal half of Q9TV68|AB021930|CAN2DD Dihydrodiol dehydrogenase from Canis familiaris (335 aa), FASTA score, opt: [...]
PPE24 protein networkhttps://string-db.org/network/83332.Rv1753cRv1753c, (MTCY28.16c), len: 1053 aa. PPE24, Member of the Mycobacterium tuberculosis PPE family of Gly-,Asn-rich proteins, similar to many e.g. YF48_MYCTU|Q10778 hypothetical protein cy48.17 (678 [...]
Rv1754c protein networkhttps://string-db.org/network/83332.Rv1754cConserved protein; Rv1754c, (MTCY28.17c), len: 563 aa. Conserved protein, has proline-rich central region. Some similarity in central region to other Mycobacterium tuberculosis proline-rich prote [...]
plcD protein networkhttps://string-db.org/network/83332.Rv1755cRv1755c, (MT1799, MTCY28.21c), len: 280 aa. Probable plcD, phospholipase C 4 (fragment) (see citations below),highly similar to C-terminus of other phospholipases e.g. CQ50771|Rv2351c|PLCA|MTP40| [...]
Rv1756c protein networkhttps://string-db.org/network/83332.Rv1756cPutative transposase; Rv1756c, (MTCY28.22c), len: 328 aa. Putative Transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described h [...]
Rv1757c protein networkhttps://string-db.org/network/83332.Rv1757cRv1757c, (MTCY28.23c), len: 108 aa. Putative Transposase for IS6110 (fragment), identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion ele [...]
cut1 protein networkhttps://string-db.org/network/83332.Rv1758Probable cutinase Cut1; Rv1758, (MTCY28.24), len: 174 aa. Probable cut1,serine esterase, cutinase family, similar to Rv2301|CUT2_MYCTU|Q50664 probable cutinase cy339.08c precursor from Mycobacter [...]
wag22 protein networkhttps://string-db.org/network/83332.Rv1759cPE-PGRS family protein Wag22; Rv1759c, (MT1807, MTCY28.25c), len: 914 aa. Wag22,antigen member (see citations below) of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich protei [...]
Rv1760 protein networkhttps://string-db.org/network/83332.Rv1760Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
Rv1761c protein networkhttps://string-db.org/network/83332.Rv1761cPossible exported protein; Rv1761c, (MTCY28.27c), len: 127 aa. Possibly exported protein with hydrophobic stretch or TMhelix at aa 15-37.
Rv1762c protein networkhttps://string-db.org/network/83332.Rv1762cUnknown protein; Rv1762c, (MTCY28.28c), len: 262 aa. Unknown protein.
Rv1763 protein networkhttps://string-db.org/network/83332.Rv1763Rv1763, (MTCY28.29), len: 108 aa. Putative Transposase for IS6110 (fragment), identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion eleme [...]
Rv1764 protein networkhttps://string-db.org/network/83332.Rv1764Putative transposase; Rv1764, (MTCY28.30), len: 328 aa. Putative Transposase for IS6110 insertion element. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase des [...]
Rv1765c protein networkhttps://string-db.org/network/83332.Rv1765cRv1765c, (MTCY28.31c), len: 365 aa. Conserved hypothetical protein, highly similar to O53461|Rv2015c|MTV018.02c conserved hypothetical protein (418 aa), (97.8% identity in 364 aa overlap). Blast [...]
Rv1766 protein networkhttps://string-db.org/network/83332.Rv1766Conserved protein; Rv1766, (MTCY28.32), len: 89 aa. Conserved protein,highly similar to P54431|YRKD_BACSU Hypothetical 7.0 kDa protein in bltr-spoIIIC intergenic region from Bacillus subtilis (63 [...]
Rv1767 protein networkhttps://string-db.org/network/83332.Rv1767Conserved protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activi [...]
PE_PGRS31 protein networkhttps://string-db.org/network/83332.Rv1768PE-PGRS family protein PE_PGRS31; Rv1768, (MTCY28.34), len: 618 aa. PE_PGRS31, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 200 [...]
Rv1769 protein networkhttps://string-db.org/network/83332.Rv1769Conserved protein; Rv1769, (MTCY28.35), len: 414 aa. Conserved protein,similar to O88066|SCI35.31|AL031541 hypothetical protein from Streptomyces coelicolor (402 aa), FASTA scores: opt: 1341, E() [...]
Rv1770 protein networkhttps://string-db.org/network/83332.Rv1770Conserved protein; Rv1770, (MTCY28.36), len: 428 aa. Conserved protein,highly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa), FASTA scores [...]
Rv1771 protein networkhttps://string-db.org/network/83332.Rv1771L-gulono-1,4-lactone dehydrogenase; Oxidizes L-gulono-1,4-lactone to L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. Can use both cytochrome c and phenazine methosulfate as [...]
Rv1772 protein networkhttps://string-db.org/network/83332.Rv1772Hypothetical protein; Rv1772, (MTCY28.38), len: 103 aa. Hypothetical unknown protein.
Rv1773c protein networkhttps://string-db.org/network/83332.Rv1773cRv1773c, (MTCY28.39), len: 248 aa. Probable transcriptional regulator belonging to IclR family, similar to ICLR_ECOLI|P16528 acetate operon repressor from Escherichia coli (274 aa), FASTA scores: [...]
Rv1774 protein networkhttps://string-db.org/network/83332.Rv1774Rv1774, (MTCY25C11.01), len: 446 aa. Probable oxidoreductase, similar to several e.g. HDNO_ARTOX|P08159 6-hydroxy-d-nicotine oxidase (458 aa), FASTA scores: opt: 417, E(): 6e-20, (28.4% identity [...]
Rv1775 protein networkhttps://string-db.org/network/83332.Rv1775Conserved hypothetical protein; Rv1775, (MTCY25C11.02), unknown, len: 272 aa. Conserved hypothetical protein, similar to O28806|AF1466 conserved hypothetical protein from Archaeoglobus fulgidus ( [...]
Rv1776c protein networkhttps://string-db.org/network/83332.Rv1776cRv1776c, (MTCY25C11.03c), len: 186 aa. Possible regulatory protein, some similarity to Mycobacterium tuberculosis Rv1255c|Q11063 hypothetical transcriptional regulator (202 aa), FASTA scores: opt [...]
cyp144 protein networkhttps://string-db.org/network/83332.Rv1777Rv1777, (MT1827, MTCY25C11.04), len: 434 aa. Probable cyp144, cytochrome p450, similar to CPXM_BACME|Q06069 cytochrome p450 (meg) (410 aa), FASTA scores: opt: 435 E(): 2.3e-16, (28.8% identity in [...]
Rv1778c protein networkhttps://string-db.org/network/83332.Rv1778cUnknown protein; Rv1778c, (MTCY25C11.05c), len: 149 aa. Unknown protein.
Rv1779c protein networkhttps://string-db.org/network/83332.Rv1779cRv1779c, (MTV049.01c), len: 597 aa. Possible integral membrane protein.
Rv1780 protein networkhttps://string-db.org/network/83332.Rv1780Conserved protein; Rv1780, (MTV049.02), len: 187 aa. Conserved protein,equivalent to Q49881|ML1380|U00021_2 cosmid L247 from Mycobacterium leprae (187 aa), FASTA scores: opt: 1000,E(): 0, (82.4% [...]
malQ protein networkhttps://string-db.org/network/83332.Rv1781cProbable 4-alpha-glucanotransferase MalQ (amylomaltase) (disproportionating enzyme) (D-enzyme); Rv1781c, (MTV049.03c), len: 724 aa. Probable malQ,4-alpha-glucanotransferase, similar to many, e.g. [...]
eccB5 protein networkhttps://string-db.org/network/83332.Rv1782ESX conserved component EccB5. ESX-5 type VII secretion system protein. Probable membrane protein; An ATPase (shown for residues 80-506). Part of the ESX-5 specialized secretion system, which is [...]
eccC5 protein networkhttps://string-db.org/network/83332.Rv1783ESX conserved component EccC5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and [...]
cyp143 protein networkhttps://string-db.org/network/83332.Rv1785cRv1785c, (MT1834, MTV049.07c), len: 393 aa. Probable cyp143, cytochrome P450 (1.14.-.-), similar to many e.g. AE0001|RZAE000101_4 Rhizobium sp. NGR234 (414 aa), FASTA scores: opt: 663, E(): 0, (3 [...]
Rv1786 protein networkhttps://string-db.org/network/83332.Rv1786Probable ferredoxin; Rv1786, (MTV049.08), len: 67 aa. Probable ferredoxin, similar to others e.g. X63601|FERS_STRGR ferredoxin from Streptomyces griseus (65 aa), FASTA scores: opt: 140, E(): 0.00 [...]
PPE25 protein networkhttps://string-db.org/network/83332.Rv1787Rv1787, (MTV049.09), len: 365 aa. PPE25, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FAS [...]
PE18 protein networkhttps://string-db.org/network/83332.Rv1788Rv1788, (MTV049.10), len: 99 aa. PE18, Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins (see citation below), similar to Z93777|MTCI364.07 Mycobacterium tuberculosis [...]
PPE26 protein networkhttps://string-db.org/network/83332.Rv1789PPE family protein PPE26; Probably plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent ac [...]
PPE27 protein networkhttps://string-db.org/network/83332.Rv1790Rv1790, (MTV049.12), len: 350 aa. PPE27, Member of the Mycobacterium tuberculosis PPE family of glycine-rich protein, similar to Z74024|MTCY274.24 Mycobacterium tuberculosis cosmid (404 aa), FAST [...]
PE19 protein networkhttps://string-db.org/network/83332.Rv1791Rv1791, (MTV049.13), len: 99 aa. PE19, Member of the Mycobacterium tuberculosis PE family, but no glycine rich C-terminus (see Brennan & Delogu 2002), highly similar to Z93777|MTCI364.07 M.tuberc [...]
esxN protein networkhttps://string-db.org/network/83332.Rv1793Rv1792, (MTV049.14), len: 98 aa. EsxM, ESAT-6 like protein (see Gey Van Pittius et al., 2001), member of Mycobacterium tuberculosis QILSS family of proteins with Rv1038c, Rv1197, Rv3620c and Rv23 [...]
espG5 protein networkhttps://string-db.org/network/83332.Rv1794Conserved protein; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. Belongs to the EspG family.
eccD5 protein networkhttps://string-db.org/network/83332.Rv1795ESX conserved component EccD5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN a [...]
mycP5 protein networkhttps://string-db.org/network/83332.Rv1796Mycosin-5; Rv1796, (MTV049.18), len: 585 aa. Probable mycP5,pro-rich membrane-anchored serine protease (mycosin) (see citations below). Member of family with four other Mycobacterium tuberculosis [...]
eccE5 protein networkhttps://string-db.org/network/83332.Rv1797ESX conserved component EccE5. ESX-5 type VII secretion system protein. Probable membrane protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN a [...]
eccA5 protein networkhttps://string-db.org/network/83332.Rv1798ESX conserved component EccA5. ESX-5 type VII secretion system protein; Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and [...]
lppT protein networkhttps://string-db.org/network/83332.Rv1799Rv1799, (MTV049.21), len: 63 aa. Probable lppT lipoprotein, has possible signal peptide and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
PPE28 protein networkhttps://string-db.org/network/83332.Rv1800Rv1800, (MTV049.22), len: 655 aa. PPE28, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, C-terminal very similar to parts of PE proteins e.g. Z92770|MTCI5.25|Rv0151c [...]
PPE29 protein networkhttps://string-db.org/network/83332.Rv1801PPE family protein PPE29; Could be required for host endothelial-cell invasion and/or intracellular survival; Belongs to the mycobacterial PPE family.
PPE30 protein networkhttps://string-db.org/network/83332.Rv1802Rv1802, (MTV049.24), len: 463 aa. PPE30, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to AL022021|MTV049.30|Rv1809 (468 aa), FASTA scores: opt: 1238, [...]
PE_PGRS32 protein networkhttps://string-db.org/network/83332.Rv1803cPE-PGRS family protein PE_PGRS32; Rv1803c, (MTV049.25c), len: 639 aa. PE_PGRS32,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Most [...]
Rv1804c protein networkhttps://string-db.org/network/83332.Rv1804cConserved protein; Rv1804c, (MTV049.26c), len: 108 aa. Conserved protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (hydrophobic stretch at N-termin [...]
Rv1805c protein networkhttps://string-db.org/network/83332.Rv1805cHypothetical protein; Rv1805c, (MTV049.27c), len: 115 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
PE20 protein networkhttps://string-db.org/network/83332.Rv1806Rv1806, (MTV049.28), len: 99 aa. PE20, Member of the Mycobacterium tuberculosis PE family of gly-, ala-rich proteins (see citation below), most similar to Rv1788|MTV049.10|AL022021 (99 aa), FASTA [...]
PPE31 protein networkhttps://string-db.org/network/83332.Rv1807Rv1807, (MTV049.29), len: 399 aa. PPE31, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1789|MTV049.11|AL022021 (393 aa), FASTA scores: opt: 1169, [...]
PPE32 protein networkhttps://string-db.org/network/83332.Rv1808Rv1808, (MTV049.30), len: 409 aa. PPE32, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to Rv1800|MTV049.22|AL022021 (655 aa), FASTA scores: opt: 1225, [...]
PPE33 protein networkhttps://string-db.org/network/83332.Rv1809Rv1809, (MTV049.31), len: 468 aa. PPE33, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, most similar to RV1802AL022021|MTV049.23 (463 aa), FASTA scores: opt: 1238, [...]
Rv1810 protein networkhttps://string-db.org/network/83332.Rv1810Conserved protein; Rv1810, (MTCY16F9.04c), len: 118 aa. Conserved protein, similar to several hypothetical Mycobacterium tuberculosis proteins that may be exported (possible N-terminal signal seq [...]
mgtC protein networkhttps://string-db.org/network/83332.Rv1811Rv1811, (MTCY16F9.03c), len: 234 aa. Possible mgtC,magnesium (Mg2+) transport P-type ATPase C (transmembrane protein), highly similar to many e.g. NP_442124.1|NC_000911 Mg2+ transport ATPase from [...]
Rv1812c protein networkhttps://string-db.org/network/83332.Rv1812cProbable dehydrogenase; Rv1812c, (MTCY16F9.02), len: 400 aa. Probable dehydrogenase, similar to other dehydrogenases/oxidases e.g. AE001947|AE001947_10 NADH dehydrogenase II of Deinococcus radiod [...]
Rv1813c protein networkhttps://string-db.org/network/83332.Rv1813cRv1813c, (MTCY16F9.01), len: 143 aa. Conserved hypothetical protein. Possibly a exported protein with potential N-terminal signal sequence. Similar to Q11050|Rv1269c|MTCY50.13 hypothetical protei [...]
erg3 protein networkhttps://string-db.org/network/83332.Rv1814Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E( [...]
Rv1815 protein networkhttps://string-db.org/network/83332.Rv1815Conserved protein; Rv1815, (MTCY1A11.28c), len: 221 aa. Conserved protein, similar to G473456 hypothetical protein from Mycobacterium fortuitum (255 aa), FASTA scores: opt: 182,E(): 3.2e-05, (29. [...]
Rv1816 protein networkhttps://string-db.org/network/83332.Rv1816Rv1816, (MTCY1A11.27c), len: 234 aa. Possible transcriptional regulatory protein. MEME analysis suggests similarity to putative Mycobacterium tuberculosis transcriptional regulators, Rv0653c, Rv0 [...]
Rv1817 protein networkhttps://string-db.org/network/83332.Rv1817Possible flavoprotein; Rv1817, (MTCY1A11.26c), len: 487 aa. Possible flavoprotein, similar to G746486 flavoprotein subunit of fumarate reductase FAD domain homologue (474 aa), FASTA scores: opt: [...]
PE_PGRS33 protein networkhttps://string-db.org/network/83332.Rv1818cPE-PGRS family protein PE_PGRS33; Induces TNF-alpha release through human Toll-like receptor 2 (TLR2) signaling pathway, leading to macrophage apoptosis. The signaling pathway involves TLR2-depen [...]
bacA protein networkhttps://string-db.org/network/83332.Rv1819cProbable drug-transport transmembrane ATP-binding protein ABC transporter BacA; ABC transporter involved in uptake of vitamin B12 and related corrinoids. Transmembrane domains (TMD) form a pore i [...]
ilvG protein networkhttps://string-db.org/network/83332.Rv1820Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS); Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of t [...]
secA2 protein networkhttps://string-db.org/network/83332.Rv1821Possible preprotein translocase ATPase SecA2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis o [...]
pgsA2 protein networkhttps://string-db.org/network/83332.Rv1822Putative cardiolipin synthase; May catalyze the biosynthesis of cardiolipin from phosphatidylglycerol (PG) and CDP-diacylglycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I famil [...]
Rv1823 protein networkhttps://string-db.org/network/83332.Rv1823Conserved protein; Rv1823, (MTCY01A11.20), len: 307 aa. Conserved protein, similar to P71582|MTCY10H4.12|RV0012 hypothetical protein CY10H4.12 from Mycobacterium tuberculosis (262 aa),FASTA score [...]
Rv1824 protein networkhttps://string-db.org/network/83332.Rv1824Rv1824, (MTCY1A11.19c), len: 121 aa. Conserved hypothetical membrane protein similar to P28265|SBP_BACSU sbp protein from Bacillus subtilis (121 aa), FASTA scores: opt: 261, E(): 1.9e-12, (38.9% [...]
Rv1825 protein networkhttps://string-db.org/network/83332.Rv1825Conserved protein; Rv1825, (MTCY1A11.18c), len: 292 aa. Conserved protein, weak similarity to Mycobacterium tuberculosis hypothetical proteins Q50610|MTCY1A11.20C|Rv1823|Z78020 (307 aa), FASTA sc [...]
gcvH protein networkhttps://string-db.org/network/83332.Rv1826Probable glycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to th [...]
garA protein networkhttps://string-db.org/network/83332.Rv1827Conserved protein with FHA domain, GarA; Involved in regulation of glutamate metabolism. Acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB.
Rv1828 protein networkhttps://string-db.org/network/83332.Rv1828Conserved protein; Transcriptional regulator that binds to its own promoter and thus may play a role in the regulation of the cotranscribed genes Rv1827 and Rv1828. Can also bind several promoter [...]
Rv1829 protein networkhttps://string-db.org/network/83332.Rv1829Conserved protein; Rv1829, (MTCY1A11.14c), len: 164 aa. Conserved protein, equivalent to O32917|MLCB1788.34|AL008609 Hypothetical protein from Mycobacterium leprae (164 aa),FASTA scores: opt: 101 [...]
Rv1830 protein networkhttps://string-db.org/network/83332.Rv1830Rv1830, (MTCY1A11.13c), len: 225 aa. Conserved hypothetical protein, equivalent to Mycobacterium leprae hypothetical protein MLCB1788.33c|AL008609|O32916 (231 aa),FASTA scores: opt: 1307, E(): 0, [...]
Rv1831 protein networkhttps://string-db.org/network/83332.Rv1831Hypothetical protein; Rv1831, (MTCY1A11.12c), len: 85 aa. Hypothetical unknown protein.
gcvB protein networkhttps://string-db.org/network/83332.Rv1832Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-am [...]
dhmA2 protein networkhttps://string-db.org/network/83332.Rv1833cPossible haloalkane dehalogenase; Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide [...]
lipZ protein networkhttps://string-db.org/network/83332.Rv1834Probable hydrolase; Rv1834, (MTCY1A11.09c), len: 288 aa. Probable lipZ,hydrolase, some similarity to haloalkane dehalogenases and D16262 hypothetical 38.9 kDa protein (335 aa), FASTA scores: opt: [...]
Rv1835c protein networkhttps://string-db.org/network/83332.Rv1835cRv1835c, (MTCY1A11.08), len: 628 aa. Conserved hypothetical protein, some similarity to putative acylases e.g. G216374 glutaryl 7-aca acylase precursor (634 aa) FASTA scores, opt: 202, E(): 3.5e- [...]
Rv1836c protein networkhttps://string-db.org/network/83332.Rv1836cConserved protein; Rv1836c, (MTCY1A11.07), len: 677 aa. Conserved protein. Equivalent to MLCB1788.28|AL008609 hypothetical protein from Mycobacterium leprae (710 aa), FASTA scores: opt: 2938, E() [...]
glcB protein networkhttps://string-db.org/network/83332.Rv1837cMalate synthase G GlcB; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA.
vapC13 protein networkhttps://string-db.org/network/83332.Rv1838cPossible toxin VapC13; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB13 (By similarity).
vapB13 protein networkhttps://string-db.org/network/83332.Rv1839cPossible antitoxin VapB13; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC13.
PE_PGRS34 protein networkhttps://string-db.org/network/83332.Rv1840cPE-PGRS family protein PE_PGRS34; Rv1840c, (MTCY359.33), len: 515 aa. PE_PGRS34,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Simil [...]
Rv1841c protein networkhttps://string-db.org/network/83332.Rv1841cRv1841c, (MTCY359.32), len: 345 aa. Conserved hypothetical membrane protein. Some similarity to O07585|YHDP_BACSU hypothetical 49.9 kDa protein from Bacillus subtilis (444 aa), FASTA scores: opt: [...]
Rv1842c protein networkhttps://string-db.org/network/83332.Rv1842cRv1842c, (MTCY359.31), len: 455 aa. Conserved hypothetical membrane protein. Similar to Z99109|0O7589 Potential integral membrane protein from Bacillus subtilis (461 aa), FASTA scores: opt: 723, [...]
guaB1 protein networkhttps://string-db.org/network/83332.Rv1843cProbable inosine-5'-monophosphate dehydrogenase GuaB1(imp dehydrogenase) (IMPDH) (IMPD); Has no inosine-5'-monophosphate dehydrogenase activity. Belongs to the IMPDH/GMPR family.
gnd1 protein networkhttps://string-db.org/network/83332.Rv1844cProbable 6-phosphogluconate dehydrogenase Gnd1; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
blaR protein networkhttps://string-db.org/network/83332.Rv1845cRv1845c, (MTCY359.28), len: 316 aa. Possible blaR,sensor-transducer protein. Conserved hypothetical transmembrane protein. Equivalent to MLCB1788.18|AL008609 Hypothetical protein from Mycobacteri [...]
blaI protein networkhttps://string-db.org/network/83332.Rv1846cTranscriptional repressor BlaI; Transcription regulator that binds to an inverted DNA repeat with the consensus sequence 5'-TAC[GT]AC-NNNNN-GT[AC]GTA-3' and regulates genes involved in antibiotic [...]
Rv1847 protein networkhttps://string-db.org/network/83332.Rv1847Conserved protein; Rv1847, (MTCY359.26c), len: 140 aa. Conserved protein, possible thioesterase, some similarity to YBDB proteins of Escherichia coli and H. influenzae e.g. P15050|YBDB_ECOLI hypo [...]
ureA protein networkhttps://string-db.org/network/83332.Rv1848Rv1848, (MTCY359.25c), len: 100 aa. UreA, urease gamma subunit. Similar to URE3_MYCTU|P50043 from Mycobacterium tuberculosis (100 aa), FASTA scores: opt: 630, E(): 1.3e-36, (99.0% identity in 100 [...]
ureB protein networkhttps://string-db.org/network/83332.Rv1849Rv1849, (MTCY359.24c), len: 104 aa. UreB, urease beta subunit. Identical to URE2_MYCTU|P50048 urease beta subunit from Mycobacterium tuberculosis (100 aa). Belongs to the urease gamma subunit fam [...]
ureC protein networkhttps://string-db.org/network/83332.Rv1850Rv1850, (MTCY359.23c), len: 577 aa. UreC, urease alpha subunit. Similar to URE1_MYCTU|P50042 from Mycobacterium tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0, (98.3% identity in 577 aa o [...]
ureF protein networkhttps://string-db.org/network/83332.Rv1851Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
ureG protein networkhttps://string-db.org/network/83332.Rv1852Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
ureD protein networkhttps://string-db.org/network/83332.Rv1853Rv1853, (MTCY359.20c), len: 208 aa. UreD, probable urease accessory protein. Similar to URED_YEREN|P42868 Urease operon ureD protein from Yersinia enterocolitica (325 aa), Fasta scores: opt: 114, [...]
ndh protein networkhttps://string-db.org/network/83332.Rv1854cRv1854c, (MTCY359.19), len: 463 aa. Probable ndh,NADH dehydrogenase (see citations below), similar to several e.g. S74826 NADH dehydrogenase from Synechocystis sp. (445 aa), FASTA score: opt: 122 [...]
Rv1855c protein networkhttps://string-db.org/network/83332.Rv1855cRv1855c, (MTCY359.18), len: 307 aa. Possible oxidoreductase, possibly a monooxygenase. Contains PS00217 Sugar transport proteins signature 2, probably fortuitously. Similar to G487716 (78-11) lin [...]
Rv1856c protein networkhttps://string-db.org/network/83332.Rv1856cRv1856c, (MTCY359.17), len: 225 aa. Possible oxidoreductase. Equivalent to MLCB1788.11c|AL008609 oxidoreductase from Mycobacterium leprae (224 aa), FASTA scores: opt: 1211, E(): 0; (80.4% identit [...]
modA protein networkhttps://string-db.org/network/83332.Rv1857Probable molybdate-binding lipoprotein ModA; Involved in the transport of molybdenum into the cell. Part of the binding-protein-dependent transport system ModABCD (By similarity).
modB protein networkhttps://string-db.org/network/83332.Rv1858Probable molybdenum-transport integral membrane protein ABC transporter ModB; Part of the binding-protein-dependent transport system ModABCD for molybdenum; probably responsible for the transloca [...]
modC protein networkhttps://string-db.org/network/83332.Rv1859Probable molybdenum-transport ATP-binding protein ABC transporter ModC; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport [...]
apa protein networkhttps://string-db.org/network/83332.Rv1860Alanine and proline-rich secreted protein Apa; A potent antigen in animals immunized with live bacteria, it induces a strong delayed-type hypersensitivity (DTH) in immunized animals. Elicits a mo [...]
Rv1861 protein networkhttps://string-db.org/network/83332.Rv1861Rv1861, (MTCY359.12c), len: 101 aa. Probable conserved transmembrane protein, showing weak similarity to AE002069|AE002069_10 hypothetical protein from Deinococcus radiodurans (146 aa), FASTA sco [...]
adhA protein networkhttps://string-db.org/network/83332.Rv1862Rv1862, (MTCY359.11), len: 346 aa. Probable adhA,alcohol dehydrogenase, similar to ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa [...]
Rv1863c protein networkhttps://string-db.org/network/83332.Rv1863cRv1863c, (MTCY359.10), len: 256 aa. Probable conserved integral membrane protein, similar to Rv0804|Z95618|MTCY7H7A.05 Hypothetical protein from Mycobacterium tuberculosis (209 aa), FASTA scores: [...]
Rv1864c protein networkhttps://string-db.org/network/83332.Rv1864cConserved protein; Rv1864c, (MTCY359.09), len: 251 aa. Conserved protein. Similar to other hypothetical proteins e.g. AL031317|SC6G4.43 from Streptomyces coelicolor cosmid 6G (233 aa), FASTA scor [...]
Rv1865c protein networkhttps://string-db.org/network/83332.Rv1865cRv1865c, (MTCY359.08), len: 286 aa. Probable short-chain dehydrogenase, highly similar to C-terminus of NP_301650.1|NC_00267 putative oxidoreductase from Mycobacterium leprae (596 aa). Also simil [...]
Rv1866 protein networkhttps://string-db.org/network/83332.Rv1866Conserved protein; Probable CoA-transferase.
Rv1867 protein networkhttps://string-db.org/network/83332.Rv1867Conserved protein; Rv1867, (MTCY359.06c), len: 494 aa. Conserved protein, some similarity to acetyl CoA synthase and to lipid carriers. FASTA best: E155295 acetyl CoA synthase (388 aa), opt: 213, [...]
Rv1868 protein networkhttps://string-db.org/network/83332.Rv1868Rv1868, (MTCY359.05c), len: 699 aa. Conserved hypothetical protein, similar to products of three consecutive ORFS in Mycobacterium leprae MLCB2052.18|Z98604|B2052 (257 aa), FASTA scores: opt: 314 [...]
Rv1869c protein networkhttps://string-db.org/network/83332.Rv1869cProbable reductase; Rv1869c, (MTCY359.04), len: 411 aa. Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelic [...]
Rv1870c protein networkhttps://string-db.org/network/83332.Rv1870cRv1870c, (MTCY359.03), len: 211 aa. Conserved hypothetical protein. Some similarity to SC6F7.17c hypothetical protein from Streptomyces coelicolor (216 aa).
Rv1871c protein networkhttps://string-db.org/network/83332.Rv1871cConserved protein; Rv1871c, (MTCY359.02), len: 129 aa. Conserved protein, similar to Mycobacterium tuberculosis hypothetical proteins Q11057|Rv1261|MTCY50.21 (149 aa), FASTA score: opt: 125, E(): [...]
lldD2 protein networkhttps://string-db.org/network/83332.Rv1872cRv1872c, (MTCY180.46, MTCY359.01), len: 414 aa (start uncertain). Possible lldD2, L-lactate dehydrogenase (cytochrome), similar to other lactate dehydrogenases and other oxidases e.g. LLDD_ECOLI| [...]
Rv1873 protein networkhttps://string-db.org/network/83332.Rv1873Rv1873, (MTCY180.45c), len: 145 aa. Conserved hypothetical protein. Some similarity to AL591783 hypothetical protein from Sinorhizobium meliloti.
Rv1874 protein networkhttps://string-db.org/network/83332.Rv1874Unknown protein; Rv1874, (MTCY180.44c), len: 228 aa. Unknown protein.
Rv1875 protein networkhttps://string-db.org/network/83332.Rv1875Conserved protein; Rv1875, (MTCY180.43c), len: 147 aa. Conserved protein. Some similarity to Mycobacterium tuberculosis hypothetical proteins e.g. Rv1155|MTCI65.22|Z95584 (147 aa), FASTA scores: [...]
bfrA protein networkhttps://string-db.org/network/83332.Rv1876Probable bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core [...]
Rv1877 protein networkhttps://string-db.org/network/83332.Rv1877Rv1877, (MTCY180.41c), len: 687 aa. Probable conserved integral membrane protein, part of major facilitator superfamily (MFS), similar to many antibiotic and drug efflux proteins. Similar to e.g. [...]
glnA3 protein networkhttps://string-db.org/network/83332.Rv1878Rv1878, (MTCY180.40c), len: 450 aa. Probable glnA3,glutamine synthetase class I, similar to many e.g. GLNA_BACCE|P19064 from Bacillus cereus (443 aa), FASTA results: opt: 497, E(): 5.2e-23, (29.0 [...]
Rv1879 protein networkhttps://string-db.org/network/83332.Rv1879Rv1879, (MTCY180.39c), len: 378 aa. Conserved hypothetical protein, similar to SCC22.14c|AL096839 hypothetical protein from Streptomyces coelicolor (368 aa),FASTA results: opt: 772, E(): 0 (40.3% [...]
cyp140 protein networkhttps://string-db.org/network/83332.Rv1880cRv1880c, (MT1929, MTCY180.38), len: 438 aa. Probable cyp140, cytochrome p450. Similar to Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% i [...]
lppE protein networkhttps://string-db.org/network/83332.Rv1881cRv1881c, (MTCY180.37), len: 140 aa. Possible lppE,lipoprotein, showing some similarity to L12238|MSG18S19K_1 19K antigen from Mycobacterium intracellulare (162 aa),FASTA scores: opt: 137, E(): 0. [...]
Rv1882c protein networkhttps://string-db.org/network/83332.Rv1882cRv1882c, (MTCY180.36), len: 277 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_250789.1|NC_002516 proba [...]
Rv1883c protein networkhttps://string-db.org/network/83332.Rv1883cRv1883c, (MTCY180.35), len: 153 aa. Conserved hypothetical protein, some similarity to hypothetical proteins e.g. Rv2778c|AL008967|MTV002.43 from Mycobacterium tuberculosis (156 aa), FASTA score: [...]
rpfC protein networkhttps://string-db.org/network/83332.Rv1884cProbable resuscitation-promoting factor RpfC; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little t [...]
Rv1885c protein networkhttps://string-db.org/network/83332.Rv1885cChorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
fbpB protein networkhttps://string-db.org/network/83332.Rv1886cDiacylglycerol acyltransferase/mycolyltransferase Ag85B; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycopr [...]
Rv1887 protein networkhttps://string-db.org/network/83332.Rv1887Hypothetical protein; Rv1887, (MTCY180.31), len: 380 aa. Hypothetical unknown protein; contains eukaryotic thiol (cysteine) proteases histidine active site at N-terminus (PS00639) and Pro-rich re [...]
Rv1888A protein networkhttps://string-db.org/network/83332.Rv1888ARv1888A, len: 57 aa. Conserved hypothetical protein. Possibly continuation of Rv1889c, part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~ 120 aa. In [...]
Rv1888c protein networkhttps://string-db.org/network/83332.Rv1888cRv1888c, (MTCY180.30), len: 186 aa. Possible transmembrane protein.
Rv1889c protein networkhttps://string-db.org/network/83332.Rv1889cRv1889c, (MTCY180.29), len: 118 aa. Conserved hypothetical protein. Part of large family of Mycobacterium tuberculosis proteins with conserved N-terminal domain of ~120 aa. Includes: Rv3399|Q5072 [...]
Rv1890c protein networkhttps://string-db.org/network/83332.Rv1890cHypothetical protein; Rv1890c, (MTCY180.28), len: 203 aa. Hypothetical unknown protein. Predicted to be an outer membrane protein (See Song et al., 2008); Belongs to the UPF0312 family.
Rv1891 protein networkhttps://string-db.org/network/83332.Rv1891Conserved protein; Rv1891, (MTCY180.27c), len: 135 aa. Conserved protein. Equivalent to MLCB561.09|AL049571 hypothetical protein from Mycobacterium leprae (134 aa), FASTA scores: opt: 800, E(): 0 [...]
Rv1892 protein networkhttps://string-db.org/network/83332.Rv1892Probable membrane protein; Rv1892, (MTCY180.26c), len: 103 aa. Probable membrane protein.
Rv1893 protein networkhttps://string-db.org/network/83332.Rv1893Rv1893, (MTCY180.25c), len: 72 aa. Conserved hypothetical protein. Equivalent to MLCB561.11|AL049571 hypothetical protein from Mycobacterium leprae (74 aa),FASTA scores: opt: 317, E(): 4.6e-15, ( [...]
Rv1894c protein networkhttps://string-db.org/network/83332.Rv1894cRv1894c, (MTCY180.24), len: 376 aa. Conserved hypothetical protein, weak similarity to some oxidoreductases e.g. Q01284 2-nitropropane dioxygenase precursor (378 aa), FASTA results: opt: 204, E() [...]
Rv1895 protein networkhttps://string-db.org/network/83332.Rv1895Rv1895, (MTCY180.23c), len: 384 aa. Possible dehydrogenase, similar to various sorbitol and alcohol dehydrogenases, and to putative glutathione-dependent aldehyde dehydrogenase e.g DHSO_BACSU|Q06 [...]
Rv1896c protein networkhttps://string-db.org/network/83332.Rv1896cConserved hypothetical protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
dtd protein networkhttps://string-db.org/network/83332.Rv1897cConserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischa [...]
Rv1898 protein networkhttps://string-db.org/network/83332.Rv1898Rv1898, (MTCY180.20c), len: 102 aa. Conserved hypothetical protein, some similarity to other hypothetical proteins e.g. Q58452 from methanococcus jannasch II (100 aa), FASTA results: opt: 152, E( [...]
lppD protein networkhttps://string-db.org/network/83332.Rv1899cPossible lipoprotein LppD; Rv1899c, (MTCY180.19), len: 343 aa. Possible lipoprotein; contains appropriately localized lipoprotein lipid attachment site (PS00013). Some similarity to C-terminal pa [...]
lipJ protein networkhttps://string-db.org/network/83332.Rv1900cRv1900c, (MTCY180.18), len: 462 aa. Probable lipJ,lignin peroxidase, with some similarity to esterases,hydrolases and hypothetical Mycobacterium tuberculosis proteins e.g. Q43936 beta-ketoadipate [...]
cinA protein networkhttps://string-db.org/network/83332.Rv1901Rv1901, (MTCY180.17c), len: 430 aa. Probable cinA-like protein, strong similarity to competence damage proteins CinA of Bacillus subtilis and S. pneumoniae. FASTA results: Q55760 hypothetical 44. [...]
nanT protein networkhttps://string-db.org/network/83332.Rv1902cRv1902c, (MTCY180.16), len: 422 aa. Probable nanT,sialic acid-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to others e.g. Q48076 sialic aci [...]
Rv1903 protein networkhttps://string-db.org/network/83332.Rv1903Rv1903, (MTCY180.15c), len: 134 aa. Probable conserved membrane protein, similar to Q53868|YPT3_STRCO hypothetical 15.9 kDa protein from Streptomyces coelicolor (148 aa) opt: 323, E(): 1.3e-16, ( [...]
Rv1904 protein networkhttps://string-db.org/network/83332.Rv1904Rv1904, (MTCY180.14c), len: 143 aa. Conserved hypothetical protein, some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. Rv2638|MTCY441.08|P71937 (148 aa), FASTA results [...]
aao protein networkhttps://string-db.org/network/83332.Rv1905cRv1905c, (MTCY180.13), len: 320 aa. Probable aao,D-amino acid oxidase, similar to many. Equivalent to AJ000521|MLCOSL672.02|O33145 Mycobacterium leprae (320 aa),FASTA results: opt: 1541, E(): 0, [...]
Rv1906c protein networkhttps://string-db.org/network/83332.Rv1906cConserved protein; Rv1906c, (MTCY180.12), len: 156 aa. Conserved protein, possibly exported protein, equivalent to Mycobacterium leprae AJ000521|MLCOSL672.01 (153 aa), FASTA scores: opt: 637, E() [...]
Rv1907c protein networkhttps://string-db.org/network/83332.Rv1907cHypothetical protein; Rv1907c, (MTCY180.11), len: 215 aa. Hypothetical unknown protein. Similar to Q50763 Ethyl methane sulphonate resistance protein from Mycobacterium tuberculosis (168 aa), FAS [...]
katG protein networkhttps://string-db.org/network/83332.Rv1908cCatalase-peroxidase-peroxynitritase T KatG; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity, oxidizing various electron donors including NADP(H). Protects M.tubercul [...]
furA protein networkhttps://string-db.org/network/83332.Rv1909cFerric uptake regulation protein FurA (fur); Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox- dependent manner; [...]
Rv1910c protein networkhttps://string-db.org/network/83332.Rv1910cProbable exported protein; Rv1910c, (MTCY180.08), len: 197 aa. Possible exported protein, very similar to upstream ORF MTCY180.07 (201 aa), FASTA score: E(): 0, (64.0% identity in 200 aa overlap) [...]
lppC protein networkhttps://string-db.org/network/83332.Rv1911cProbable lipoprotein LppC; Probably involved in bacterial recognition and uptake by its host (human).
fadB5 protein networkhttps://string-db.org/network/83332.Rv1912cRv1912c, (MTCY180.06), len: 334 aa. Possible fadB5,oxidoreductase, similar to various oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase, quinone oxidoreductases,and polyketide synthases, e.g. NP_1 [...]
Rv1913 protein networkhttps://string-db.org/network/83332.Rv1913Rv1913, (MTCY180.05c), len: 250 aa. Conserved hypothetical protein, slight similarity to dehydrase and beta-lactamase precursors e.g. Q02057 dehydrase from Streptomyces coelicolor (297 aa), FASTA [...]
Rv1914c protein networkhttps://string-db.org/network/83332.Rv1914cUnknown protein; Rv1914c, (MTCY180.04), len: 135 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
aceAa protein networkhttps://string-db.org/network/83332.Rv1915Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl); Together with AceAb, they could catalyze the formation of succinate and glyoxylate from isocitrate.
aceAb protein networkhttps://string-db.org/network/83332.Rv1916Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl); Together with AceAa, they could catalyze the formation of succinate and glyoxylate from isocitrate.
PPE34 protein networkhttps://string-db.org/network/83332.Rv1917cPPE family protein PPE34; Facilitates a shift in the ensuing immunity toward the Th2 phenotype and could aid in immune evasion by mycobacteria. Interacts with human Toll-like receptor 2 (TLR2) an [...]
PPE35 protein networkhttps://string-db.org/network/83332.Rv1918cRv1918c, (MTV050.02c), len: 987 aa. PPE35, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins. Similar to MTCY28.16|Z95890 Mycobacterium tuberculosis cosmid (1053 aa), F [...]
Rv1919c protein networkhttps://string-db.org/network/83332.Rv1919cConserved protein; Rv1919c, (MTV050.03c), len: 154 aa. Conserved protein, shows weak similarity to several major pollen antigens e.g. Z72431|BVGC25_1 major allergen bet V 1 from Betula verrucosa [...]
Rv1920 protein networkhttps://string-db.org/network/83332.Rv1920Probable membrane protein; Rv1920, (MTV050.04), len: 287 aa. Probable membrane protein, similar to AL0215|SC10A5.04 putative membrane protein from Streptomyces coelicolor cosmid 10A5 (295 aa),FAS [...]
lppF protein networkhttps://string-db.org/network/83332.Rv1921cRv1921c, (MTCY09F9.43-MTV050.05c), len: 423 aa. Probable lppF, conserved lipoprotein, similar to G403173 lipoprotein precursor (fragment) from Rhodococcus erythropolis (225 aa), fasta scores: opt [...]
Rv1922 protein networkhttps://string-db.org/network/83332.Rv1922Rv1922, (MTCY09F9.42c), len: 371 aa. Probable conserved lipoprotein, possibly peptidase similar to many peptidases, e.g. P15555|DAC_STRSQ D-alanyl-D-alanine carboxypeptidase from Streptomyces sp. [...]
lipD protein networkhttps://string-db.org/network/83332.Rv1923Probable lipase LipD; Rv1923, (MTCY09F9.41c), len: 446 aa. Probable lipD,hydrolase lipase, similar to esterases and beta-lactamases e.g. G151214 esterase, (389 aa), fasta scores: opt: 569,E(): 5. [...]
Rv1924c protein networkhttps://string-db.org/network/83332.Rv1924cUnknown protein; Rv1924c, (MTCY09F9.40), len: 126 aa. Unknown protein.
fadD31 protein networkhttps://string-db.org/network/83332.Rv1925Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase); Rv1925, (MTCY09F9.39c), len: 620 aa. Probable fadD31, acyl-CoA synthetase, highly similar to others from Mycobacterium l [...]
mpt63 protein networkhttps://string-db.org/network/83332.Rv1926cImmunogenic protein Mpt63 (antigen Mpt63/MPB63) (16 kDa immunoprotective extracellular protein); Rv1926c, (MT1977, MTCY09F9.38), len: 159 aa. Mpt63 (alternate gene name: mpb63), immunogenic prote [...]
Rv1927 protein networkhttps://string-db.org/network/83332.Rv1927Rv1927, (MTCY09F9.37c), len: 257 aa. Conserved hypothetical protein, similar to SCG11A.10c|AL133210 hypothetical protein from Streptomyces coelicolor (252 aa),FASTA scores: opt: 729, E(): 0, (48. [...]
Rv1928c protein networkhttps://string-db.org/network/83332.Rv1928cRv1928c, (MTCY09F9.36), len: 255 aa. Probable short-chain dehydrogenase/reductase, highly similar to others e.g. NP_228109.1|NC_000853 oxidoreductase (short chain dehydrogenase/reductase family) [...]
Rv1929c protein networkhttps://string-db.org/network/83332.Rv1929cRv1929c, MTCY09F9.35, len: 214 aa. Conserved hypothetical protein, similar to SC4G6.14|AL096884 hypothetical protein from Streptomyces coelicolor (211 aa),FASTA scores: opt: 416, E(): 2.4e-22, (3 [...]
Rv1930c protein networkhttps://string-db.org/network/83332.Rv1930cRv1930c, MTCY09F9.34, len: 174 aa. Conserved hypothetical protein, similar to SC5F2A.30|AL049587 hypothetical protein from Streptomyces coelicolor (211 aa),FASTA scores: opt: 307, E(): 2.8e-13, ( [...]
Rv1931c protein networkhttps://string-db.org/network/83332.Rv1931cProbable transcriptional regulatory protein; Controls the expression of genes important for virulence.
tpx protein networkhttps://string-db.org/network/83332.Rv1932Probable thiol peroxidase Tpx; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell pro [...]
fadE18 protein networkhttps://string-db.org/network/83332.Rv1933cRv1933c, (MTCY09F9.31), len: 363 aa. Probable fadE18, acyl-CoA dehydrogenase, similar to many e.g. CAB61609.1|AL133210 putative acyl-CoA dehydrogenase from Streptomyces coelicolor (362 aa); NP_42 [...]
fadE17 protein networkhttps://string-db.org/network/83332.Rv1934cRv1934c, (MTCY09F9.30), len: 409 aa. Probable fadE17, acyl-CoA dehydrogenase, highly similar to ACD_MYCLE|P46703 acyl-CoA dehydrogenase from Mycobacterium leprae (389 aa), FASTA scores: opt: 414, [...]
echA13 protein networkhttps://string-db.org/network/83332.Rv1935cPossible enoyl-CoA hydratase EchA13 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv1935c, (MTCY09F9.29), len: 318 aa. Possible echA13, enoyl-CoA hydratase, similar to others and [...]
Rv1936 protein networkhttps://string-db.org/network/83332.Rv1936Possible monooxygenase; Rv1936, (MTCY09F9.28c), len: 369 aa. Possible monooxygenase, similar to LXA2_PHOLU|P23146 alkanal monooxygenase alpha chain (362 aa), FASTA scores: opt: 196,E(): 6.3e-06, [...]
Rv1937 protein networkhttps://string-db.org/network/83332.Rv1937Possible oxygenase; Rv1937, (MTCY09F9.27c), len: 839 aa. Possible oxygenase, similar in N-terminus to N-terminal part (approx. 350 aa) of dioxygenases (including ring-hydroxylating dioxygenase el [...]
ephB protein networkhttps://string-db.org/network/83332.Rv1938Probable epoxide hydrolase EphB (epoxide hydratase); Could be involved in detoxification of extraneous host-cell epoxides. Catalyzes the hydrolysis of epoxide-containing substrates. Belongs to th [...]
Rv1939 protein networkhttps://string-db.org/network/83332.Rv1939Rv1939, (MTCY09F9.25c), len: 171 aa. Probable oxidoreductase, similar to NP_302637.1|NC_002677 probable oxidoreductase from Mycobacterium leprae (162 aa) Also similar to NTAB_CHELE|P54990 nitrilo [...]
ribA1 protein networkhttps://string-db.org/network/83332.Rv1940Rv1940, (MTCY09F9.24c), len: 353 aa. Probable ribA1,Riboflavin biosynthesis protein, similar to GCH2_BACSU|P17620 gtp cyclohydrolase II (398 aa), FASTA scores: opt: 682, E(): 0, (37.7% identity i [...]
Rv1941 protein networkhttps://string-db.org/network/83332.Rv1941Rv1941, (MTCY09F9.23c), len: 256 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases, generally belonging to SDR family, e.g. NP_299015.1|NC_002488 2,5- [...]
mazF5 protein networkhttps://string-db.org/network/83332.Rv1942cPossible toxin MazF5; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cogn [...]
mazE5 protein networkhttps://string-db.org/network/83332.Rv1943cPossible antitoxin MazE5; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin MazF5.
Rv1944c protein networkhttps://string-db.org/network/83332.Rv1944cConserved protein; Rv1944c, (MTCY09F9.20), len: 196 aa. Conserved protein, similar to C-terminal part of SCE20.29|AL136058|CAB65585.1 hypothetical protein from Streptomyces coelicolor (338 aa), b [...]
Rv1945 protein networkhttps://string-db.org/network/83332.Rv1945Conserved hypothetical protein; Rv1945, (MTCY09F9.19c), len: 454 aa. Member of Mycobacterium tuberculosis REP13E12 repeat family. Similar to several others, best with Rv1148c|Z95584|MTCI65.15 (48 [...]
lppG protein networkhttps://string-db.org/network/83332.Rv1946cPossible lipoprotein; Rv1946c, (MTCY09F9.18), len: 150 aa. Possible lppG,conserved lipoprotein, showing some similarity to Rv1943c|MTCY09F9.21 conserved hypothetical protein from Mycobacterium tu [...]
Rv1947 protein networkhttps://string-db.org/network/83332.Rv1947Hypothetical protein; Rv1947, (MTCY09F9.17c), len: 133 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1948c protein networkhttps://string-db.org/network/83332.Rv1948cHypothetical protein; Rv1948c, (MTCY09F9.16), len: 116 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv1949c protein networkhttps://string-db.org/network/83332.Rv1949cRv1949c, (MTCY09F9.15), len: 319 aa. Conserved hypothetical protein, partial ORF. Rv1949c and Rv1950c|MTCY09F9.14 are similar but frameshifted with respect to Rv2077c|MTCY49.16C|Q10685 hypothetic [...]
Rv1950c protein networkhttps://string-db.org/network/83332.Rv1950cRv1950c, (MTCY09F9.14), len: 63 aa. Conserved hypothetical protein, partial ORF. Highly similar to N-terminus of Rv2077c|MTCY49.16C|Q10685 hypothetical 33.3 kDa protein (323 aa), FASTA scores: op [...]
Rv1951c protein networkhttps://string-db.org/network/83332.Rv1951cRv1951c, (MTCY09F9.13), len: 98 aa. Conserved hypothetical protein, similar to Mycobacterium tuberculosis hypothetical protein Rv2541 (135 aa) (40.9% identity in 88 aa overlap).
vapB14 protein networkhttps://string-db.org/network/83332.Rv1952Possible antitoxin VapB14; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapB14.
vapC14 protein networkhttps://string-db.org/network/83332.Rv1953Possible toxin VapC14; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB14 (By similarity); Belongs to the PINc/VapC protein family.
Rv1954A protein networkhttps://string-db.org/network/83332.Rv1954ARv1954A, len: 100 aa. Hypothetical unknown protein.
Rv1954c protein networkhttps://string-db.org/network/83332.Rv1954cHypothetical protein; Rv1954c, (MTCY09F9.10), len: 173 aa. Hypothetical unknown protein, end overlaps next ORF upstream, Rv1955 (MTCY09F9.09c).
higB protein networkhttps://string-db.org/network/83332.Rv1955Possible toxin HigB; Toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis inhibits colony formation and cell growth. Ectopic expression i [...]
higA protein networkhttps://string-db.org/network/83332.Rv1956Possible antitoxin HigA; Antitoxin component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin HigB1. Neutrali [...]
secBL protein networkhttps://string-db.org/network/83332.Rv1957Hypothetical protein; Chaperone component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Prevents antitoxin HigA1 aggregation in vitro at a 1:3 chaperone:antitoxin ratio, probabl [...]
Rv1958c protein networkhttps://string-db.org/network/83332.Rv1958cHypothetical protein; Rv1958c, (MTCY09F9.06), len: 204 aa. Hypothetical unknown protein, questionable ORF.
parE1 protein networkhttps://string-db.org/network/83332.Rv1959cPossible toxin ParE1; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpressio [...]
parD1 protein networkhttps://string-db.org/network/83332.Rv1960cPossible antitoxin ParD1; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin ParE1.
Rv1961 protein networkhttps://string-db.org/network/83332.Rv1961Hypothetical protein; Rv1961, MTCY09F9.03c, len: 164 aa. Hypothetical unknown protein.
vapB35 protein networkhttps://string-db.org/network/83332.Rv1962APossible antitoxin VapB35; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC35.
vapC35 protein networkhttps://string-db.org/network/83332.Rv1962cPossible toxin VapC35. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
mce3R protein networkhttps://string-db.org/network/83332.Rv1963cProbable transcriptional repressor (probably TetR-family) Mce3R; Mce3R represses the transcription of mce3 operon and downregulates its own expression, but does not affect the transcription of mc [...]
yrbE3A protein networkhttps://string-db.org/network/83332.Rv1964Rv1964, (MTV051.02), len: 265 aa. YrbE3A,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuber [...]
yrbE3B protein networkhttps://string-db.org/network/83332.Rv1965Rv1965, (MTV051.03), len: 271 aa. YrbE4B,hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuber [...]
mce3A protein networkhttps://string-db.org/network/83332.Rv1966Mce-family protein Mce3A; Rv1966, (MTV051.04), len: 425 aa. Mce3A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
mce3B protein networkhttps://string-db.org/network/83332.Rv1967Mce-family protein Mce3B; Rv1967, (MTV051.05), len: 342 aa. Mce3B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
mce3C protein networkhttps://string-db.org/network/83332.Rv1968Mce-family protein Mce3C; Rv1968, (MTV051.06), len: 410 aa. Mce3C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
mce3D protein networkhttps://string-db.org/network/83332.Rv1969Mce-family protein Mce3D; Rv1969, (MTV051.07), len: 423 aa. Mce3D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tube [...]
lprM protein networkhttps://string-db.org/network/83332.Rv1970Rv1970, (MTV051.08), len: 377 aa. Possible lprM (alternate gene name: mce3E), lipoprotein which belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly [...]
mce3F protein networkhttps://string-db.org/network/83332.Rv1971Mce-family protein Mce3F; Rv1971, (MTV051.09), len: 437 aa. Mce3F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculosi [...]
Rv1972 protein networkhttps://string-db.org/network/83332.Rv1972Rv1972, (MTV051.10), len: 191 aa. Probable conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several Mycobacterium tuberculosis proteins e.g. Rv1363c|Z75555|MTCY [...]
Rv1973 protein networkhttps://string-db.org/network/83332.Rv1973Rv1973, (MTV051.11), len: 160 aa. Possible conserved Mce-associated membrane protein. Probably part of mce3 operon. Similar to several other proteins from Mycobacterium tuberculosis e.g. Rv1362c| [...]
Rv1974 protein networkhttps://string-db.org/network/83332.Rv1974Rv1974, (MTV051.12), len: 125 aa. Probable conserved membrane protein, weakly similar to other Mycobacterium tuberculosis proteins e.g. Rv1271c|Z77137|MTCY50.11 (113 aa), FASTA scores: opt: 98, E [...]
Rv1975 protein networkhttps://string-db.org/network/83332.Rv1975Rv1975, (MTV051.13), len: 221 aa. Conserved hypothetical protein, showing some similarity to AJ251435 hypothetical protein from Mycobacterium avium subsp. paratuberculosis (193 aa). Predicted to [...]
Rv1976c protein networkhttps://string-db.org/network/83332.Rv1976cRv1976c, (MTV051.14), len: 135 aa. Conserved hypothetical protein, similar to SC1C3.03c|AL023702 hypothetical protein from Streptomyces coelicolor (125 aa),FASTA score: opt: 223, E(): 3.3e-08, (3 [...]
Rv1977 protein networkhttps://string-db.org/network/83332.Rv1977Conserved protein; Rv1977, (MTV051.15), len: 348 aa. Conserved protein,similar to SCC123.20|AL136518 hypothetical protein from Streptomyces coelicolor (402 aa), blastp scores: Score = 311 bits (7 [...]
Rv1978 protein networkhttps://string-db.org/network/83332.Rv1978Conserved protein; Rv1978, (MTV051.16), len: 282 aa. Conserved protein,similar to several hypothetical proteins and methyltransferases e.g. X86780|SHGCPIR.15 methyltransferase from S. hygroscopic [...]
Rv1979c protein networkhttps://string-db.org/network/83332.Rv1979cPossible conserved permease; Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily.
mpt64 protein networkhttps://string-db.org/network/83332.Rv1980cImmunogenic protein Mpt64 (antigen Mpt64/MPB64); Rv1980c, (MT2032, MTCY39.39), len: 228 aa. Mpt64 (alternate gene name: mpb64), immunogenic protein (alternate gene name: mpb64) (see citations bel [...]
nrdF1 protein networkhttps://string-db.org/network/83332.Rv1981cRibonucleoside-diphosphate reductase subunit beta nrdF1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleot [...]
vapB36 protein networkhttps://string-db.org/network/83332.Rv1982APossible antitoxin VapB36; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC36.
vapC36 protein networkhttps://string-db.org/network/83332.Rv1982cPossible toxin VapC36. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB36 (By similarity). Belongs to the PINc/VapC protein f [...]
PE_PGRS35 protein networkhttps://string-db.org/network/83332.Rv1983PE-PGRS family protein PE_PGRS35; Rv1983, (MTCY39.36c), len: 558 aa. PE_PGRS35, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
cfp21 protein networkhttps://string-db.org/network/83332.Rv1984cRv1984c, (MTCY39.35), len: 217 aa. Cfp21, probable cutinase precursor with N-terminal signal sequence, similar to P41744|CUTI_ALTBR cutinase precursor from Alternaria brassicicola (209 aa), FASTA [...]
lysG protein networkhttps://string-db.org/network/83332.Rv1985cProbable transcriptional regulatory protein (probably LysR-family); Positively regulates the expression of the exporter LysE and represses its own expression. Activity requires the presence of a [...]
lysE protein networkhttps://string-db.org/network/83332.Rv1986Probable conserved integral membrane protein; Catalyzes the efflux of L-lysine.
Rv1987 protein networkhttps://string-db.org/network/83332.Rv1987Possible chitinase; Rv1987, (MTCY39.32c), len: 142 aa. Possible chitinase, similar to several e.g. P36909|CHIT_STRLI chitinase c precursor (619 aa) FASTA scores, opt: 324, E(): 1.2e-14, (39.5% id [...]
erm(37) protein networkhttps://string-db.org/network/83332.Rv1988Rv1988, (MTCY39.31c), len: 179 aa. Probable erm(37),23S rRNA methyltransferase, similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa), FASTA scores: opt: 259, E(): 2e-11, (35.1 [...]
mbcT protein networkhttps://string-db.org/network/83332.Rv1989cHypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Neutralized by cognate antitoxin MbcA. Degrades NAD(+) by phosphorolysis. Expression in the absence of its cognate [...]
Rv1990A protein networkhttps://string-db.org/network/83332.Rv1990ARv1990A, len: 111 aa. Possible dehydrogenase (fragment), similar to N-terminal part of several dehydrogenases and hypothetical proteins, e.g. Rv2750|MTV002.15|AL008967 from Mycobacterium tubercul [...]
mbcA protein networkhttps://string-db.org/network/83332.Rv1990cProbable transcriptional regulatory protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active si [...]
mazE6 protein networkhttps://string-db.org/network/83332.Rv1991AAntitoxin MazE6; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis counteracts the ribonuclease activity of cognate toxin MazF6.
mazF6 protein networkhttps://string-db.org/network/83332.Rv1991cToxin MazF6; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and in M.smegmatis partially inhibits cell growth and colony formation; its toxic effect is neutra [...]
ctpG protein networkhttps://string-db.org/network/83332.Rv1992cRv1992c, (MTCY39.27), len: 771 aa. Probable ctpG,metal cation-transporting P-type ATPase G (transmembrane protein), similar to others, especially cadmium-transporting ATPases, e.g. NP_244904.1|NC [...]
Rv1993c protein networkhttps://string-db.org/network/83332.Rv1993cConserved protein; Rv1993c, (MTCY39.26), len: 90 aa. Conserved protein,very similar to Rv3269|Z92771|MTCY71.09 hypothetical protein from Mycobacterium tuberculosis (93 aa), FASTA results: opt: 30 [...]
cmtR protein networkhttps://string-db.org/network/83332.Rv1994cMetal sensor transcriptional regulator CmtR (ArsR-SmtB family); Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from t [...]
Rv1995 protein networkhttps://string-db.org/network/83332.Rv1995Unknown protein; Rv1995, (MTCY39.24c), len: 255 aa. Unknown protein.
Rv1996 protein networkhttps://string-db.org/network/83332.Rv1996Rv1996, (MTCY39.23c), len: 317 aa. Universal stress protein family protein. Similar to several Mycobacterium tuberculosis hypothetical proteins e.g. Rv2005c|Q10851|YK05_MYCTU (295 aa), FASTA scor [...]
ctpF protein networkhttps://string-db.org/network/83332.Rv1997Rv1997, (MTCY39.22c, MTCY39.21c), len: 905 aa. Probable ctpF, metal cation-transporting P-type ATPase F (transmembrane protein), highly similar to others e.g. NP_250120.1|NC_002516 probable catio [...]
Rv1998c protein networkhttps://string-db.org/network/83332.Rv1998cConserved protein; Rv1998c, (MTCY39.20), len: 258 aa. Conserved protein, showing some similarity with other hypothetical proteins e.g. U82823|SEU82823.03 Saccharopolyspora erythraea (266 aa), FAS [...]
Rv1999c protein networkhttps://string-db.org/network/83332.Rv1999cProbable conserved integral membrane protein; Probable amino-acid or metabolite transport protein. Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Rv2000 protein networkhttps://string-db.org/network/83332.Rv2000Unknown protein; Rv2000, (MTCY39.18c), len: 537 aa. Unknown protein.
Rv2001 protein networkhttps://string-db.org/network/83332.Rv2001Rv2001, (MTCY39.17c), len: 250 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0466.
fabG3 protein networkhttps://string-db.org/network/83332.Rv20023-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; Rv2002, (MTCY39.16c), len: 260 aa. FabG3,20-beta-hydroxysteroid dehydrogenase. Contains PS00061 Short-chain alcohol dehydrogenase family signatu [...]
Rv2003c protein networkhttps://string-db.org/network/83332.Rv2003cRv2003c, (MTCY39.14), len: 285 aa. Conserved hypothetical protein.
Rv2004c protein networkhttps://string-db.org/network/83332.Rv2004cConserved protein; Some isolated peptides of this protein are able to bind to human U937 monocytoblastic and A549 epithelial cell lines.
Rv2005c protein networkhttps://string-db.org/network/83332.Rv2005cUniversal stress protein family protein; Probably involved in aminoglycosides resistance and virulence. Overexpression increases resistance to the aminoglycosides amikacin (AK) and kanamycin (KM) [...]
otsB1 protein networkhttps://string-db.org/network/83332.Rv2006Rv2006, (MTCY39.11c), len: 1327 aa. OtsB1,trehalose-6-phosphate phosphatase (see citations below). Belongs to Glycosyl hydrolases family 65. Note that previously known as otsB. Predicted possible [...]
fdxA protein networkhttps://string-db.org/network/83332.Rv2007cFerredoxin FdxA; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Rv2008c protein networkhttps://string-db.org/network/83332.Rv2008cRv2008c, (MTCY39.09), len: 441 aa. Conserved hypothetical protein. Contains PS00017 ATP/GTP-binding site motif A, PS00501 Signal peptidases I serine active site. Also contains helix-turn-helix mo [...]
vapB15 protein networkhttps://string-db.org/network/83332.Rv2009Antitoxin VapB15; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC15. Partially inhibits the RNase activit [...]
vapC15 protein networkhttps://string-db.org/network/83332.Rv2010Toxin VapC15; Toxic component of a type II toxin-antitoxin (TA) system. Degrades total E.coli RNA, which is partially inhibited by cognate antitoxin VapB15. Upon expression in M.smegmatis inhibit [...]
Rv2011c protein networkhttps://string-db.org/network/83332.Rv2011cRv2011c, (MTCY39.06), len: 143 aa. Conserved hypothetical protein, probable transcription repressor. Contains IPR011991 Winged helix-turn-helix transcription repressor DNA-binding domain.
Rv2012 protein networkhttps://string-db.org/network/83332.Rv2012Rv2012, (MTCY39.05c), len: 164 aa. Conserved hypothetical protein.
Rv2013 protein networkhttps://string-db.org/network/83332.Rv2013Transposase; Rv2013, (MTCY39.04c), len: 159 aa. Transposase,shows similarity to N-terminal part of transposase and insertion element hypothetical proteins. Length changed since first submission ( [...]
Rv2014 protein networkhttps://string-db.org/network/83332.Rv2014Transposase; Rv2014, (MTCY39.03c), len: 196 aa. Transposase,similar to insertion elements; possibly made by frameshifting with respect to Rv2013. Length changed since first submission.
Rv2015c protein networkhttps://string-db.org/network/83332.Rv2015cRv2015c, (MTV018.02c), len: 418 aa. Conserved hypothetical protein. Nearly identical to Mycobacterium tuberculosis Rv1765c|MTCY28.31c, (378 aa), an ORF starting next to ISB9, and ending in IS6110 [...]
Rv2016 protein networkhttps://string-db.org/network/83332.Rv2016Hypothetical protein; Rv2016, (MTV018.03), len: 191 aa. Hypothetical protein.
Rv2017 protein networkhttps://string-db.org/network/83332.Rv2017Transcriptional regulatory protein; Rv2017, (MTV018.04), len: 346 aa. Transcriptional regulator. Contains PS00142 Neutral zinc metallopeptidases,zinc-binding region signature in C-terminal half, [...]
vapB45 protein networkhttps://string-db.org/network/83332.Rv2018Conserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC45.
vapC45 protein networkhttps://string-db.org/network/83332.Rv2019Conserved protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB45.
Rv2020c protein networkhttps://string-db.org/network/83332.Rv2020cRv2020c, (MTV018.07c), len: 99 aa. Conserved hypothetical protein, nearly identical to C-terminal part of hypothetical protein RvD1-Rv2024c' from Mycobacterium bovis BCG (1606 aa) emb|CAB44655.1| [...]
higA2 protein networkhttps://string-db.org/network/83332.Rv2021cTranscriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB2.
higB2 protein networkhttps://string-db.org/network/83332.Rv2022cConserved protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA2. Belongs to the mycobacterial HigB family.
Rv2023c protein networkhttps://string-db.org/network/83332.Rv2023cHypothetical protein; Rv2023c, (MTV018.10c), len: 119 aa. Hypothetical protein, alternative upstream start possible.
Rv2024c protein networkhttps://string-db.org/network/83332.Rv2024cRv2023A, len: 152 aa. Hypothetical unknown protein (pseudogene), equivalent to the C-terminus of Q8VJS0|MT2080 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (225 aa), FASTA [...]
Rv2025c protein networkhttps://string-db.org/network/83332.Rv2025cConserved membrane protein; Rv2025c, (MTV018.12c), len: 332 aa. Conserved transmembrane protein, involved in transport of metal ions,contains IPR002524 Cation efflux protein domain; Belongs to th [...]
Rv2026c protein networkhttps://string-db.org/network/83332.Rv2026cRv2026c, (MTV018.13c), len: 294 aa. Universal stress protein family protein, contains IPR006016 UspA domain.
dosT protein networkhttps://string-db.org/network/83332.Rv2027cTwo component sensor histidine kinase DosT; Interacts with the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Required for full induction of the [...]
Rv2028c protein networkhttps://string-db.org/network/83332.Rv2028cRv2028c, (MTV018.15c), len: 279 aa. Universal stress protein family protein, highly similar to many, contains IPR006016 UspA domain.
pfkB protein networkhttps://string-db.org/network/83332.Rv2029c6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of gly [...]
Rv2030c protein networkhttps://string-db.org/network/83332.Rv2030cConserved protein; Rv2030c, (MTV018.17c), len: 681 aa. Conserved protein. Predicted possible vaccine candidate (See Zvi et al., 2008).
hspX protein networkhttps://string-db.org/network/83332.Rv2031cHeat shock protein HspX (alpha-crystallin homolog) (14 kDa antigen) (HSP16.3); Acts as a chaperone, as it has a significant ability to suppress the thermal denaturation of alcohol dehydrogenase. [...]
acg protein networkhttps://string-db.org/network/83332.Rv2032Conserved protein Acg; Rv2032, (MTV018.19), len: 331 aa. Acg (for acr-coregulated gene), conserved protein possibly member of a superfamily of classical nitroreductases (see Purkayastha et al., 2 [...]
Rv2033c protein networkhttps://string-db.org/network/83332.Rv2033cRv2033c, (MTV018.20), len: 280 aa. Conserved hypothetical protein, similar to many.
Rv2034 protein networkhttps://string-db.org/network/83332.Rv2034ArsR repressor protein; Involved in the regulation of lipid metabolism and hypoxic response. Positively regulates transcription of various genes, such as phoP, groEL2 and dosR. Negatively regulat [...]
Rv2035 protein networkhttps://string-db.org/network/83332.Rv2035Rv2035, (MTV018.22), len: 162 aa. Conserved hypothetical protein, similar to many. Contains IPR013538 Activator of Hsp90 ATPase homologue 1-like.
Rv2036 protein networkhttps://string-db.org/network/83332.Rv2036Rv2036, (MTV018.23), len: 213 aa. Conserved hypothetical protein; similar to many.
Rv2037c protein networkhttps://string-db.org/network/83332.Rv2037cRv2037c, (MTV018.24c), len: 324 aa. Conserved transmembrane protein, similar to many. Alternative nucleotide at position 2282787 (C->T; C312Y) has been observed. Contains IPR016035 Acyl transfera [...]
Rv2038c protein networkhttps://string-db.org/network/83332.Rv2038cRv2038c, (MTV018.25c), len: 357 aa. Probable sugar-transport ATP-binding protein ABC transporter (see citation below), similar to many. Contains PS00211 ABC transporters family signature and PS00 [...]
Rv2039c protein networkhttps://string-db.org/network/83332.Rv2039cRv2039c, (MTV018.26c), len: 280 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), similar to many. Contains PS00402 Binding-protein-dependent transport [...]
Rv2040c protein networkhttps://string-db.org/network/83332.Rv2040cRv2040c, (MTV018.27c), len: 300 aa. Probable sugar-transport integral membrane protein ABC transporter (see citation below), similar to many.
Rv2041c protein networkhttps://string-db.org/network/83332.Rv2041cRv2041c, (MTV018.28c), len: 439 aa. Probable sugar-binding lipoprotein component of sugar transport system, similar to many. Contains signal sequence and appropriately positioned PS00013 Prokaryo [...]
Rv2042c protein networkhttps://string-db.org/network/83332.Rv2042cConserved protein; Rv2042c, (MTV018.29c), len: 265 aa. Conserved protein, similar to many.
pncA protein networkhttps://string-db.org/network/83332.Rv2043cPyrazinamidase/nicotinamidase PncA (PZase); Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinami [...]
Rv2044c protein networkhttps://string-db.org/network/83332.Rv2044cRv2044c, (MTV018.31c), len: 105 aa. Conserved hypothetical protein, similar to many.
lipT protein networkhttps://string-db.org/network/83332.Rv2045cRv2045c, (MTV018.32c), len: 511 aa. LipT,carboxylesterase, similar to many. Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site; Be [...]
lppI protein networkhttps://string-db.org/network/83332.Rv2046Rv2046, (MTV018.33), len: 218 aa. Probable lppI,lipoprotein contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
Rv2047c protein networkhttps://string-db.org/network/83332.Rv2047cRv2047c, (MTV018.34c), len: 854 aa. Conserved hypothetical protein, similar to many. Contains IPR016040 NAD(P)-binding domain at N-terminus; Belongs to the PEP-utilizing enzyme family.
pks12 protein networkhttps://string-db.org/network/83332.Rv2048cPolyketide synthase Pks12; Rv2048c, (MTV018.35c), len: 4151 aa. Pks12,polyketide synthase similar to many. Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthas [...]
Rv2049c protein networkhttps://string-db.org/network/83332.Rv2049cRv2049c, (MTV018.36c), len: 74 aa. Conserved hypothetical protein.
rbpA protein networkhttps://string-db.org/network/83332.Rv2050Conserved protein; Binds to RNA polymerase (RNAP), stimulating and stabilizing the formation of stable RNAP promoter complexes up to 2-fold from principal sigma factor SigA-dependent but not alte [...]
ppm1 protein networkhttps://string-db.org/network/83332.Rv2051cPolyprenol-monophosphomannose synthase Ppm1; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; In the N-term [...]
Rv2052c protein networkhttps://string-db.org/network/83332.Rv2052cConserved protein; Rv2052c, (MTV018.39c), len: 534 aa. Conserved protein, similar to many. Contains IPR013108 Amidohydrolase 3 domain.
fxsA protein networkhttps://string-db.org/network/83332.Rv2053cRv2053c, (MTV018.40c-MTCY63A.07), len: 175 aa. Probable fxsA, transmembrane protein. Contains IPR007313 FxsA cytoplasmic membrane protein domain in N-terminus.
Rv2054 protein networkhttps://string-db.org/network/83332.Rv2054Conserved protein; Rv2054, (MTCY63A.06c), len: 237 aa. Conserved protein, similar to many. Contains IPR002925 Dienelactone hydrolase domain.
rpsR2 protein networkhttps://string-db.org/network/83332.Rv2055c30S ribosomal protein S18 RpsR2; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial r [...]
rpsN2 protein networkhttps://string-db.org/network/83332.Rv2056c30S ribosomal protein S14 RpsN2; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to [...]
rpmG1 protein networkhttps://string-db.org/network/83332.Rv2057cRv2057c, (MTCY63A.03), len: 54 aa. rpmG1, 50S ribosomal protein L33, similar to many. Note that previously known as rpmG; Belongs to the bacterial ribosomal protein bL33 family.
rpmB2 protein networkhttps://string-db.org/network/83332.Rv2058cRv2058c, (MTCY63A.02), len: 78 aa. rpmB2, 50S ribosomal protein L28, very similar to rL28 of M. tuberculosis. Also similar to rpmB (Rv0105c) of Mycobacterium tuberculosis; Belongs to the bacteria [...]
Rv2059 protein networkhttps://string-db.org/network/83332.Rv2059Rv2059, (MTCY63A.01c), len: 511 aa. Conserved hypothetical protein. Some similarity to EWLA protein gp|U52850|ERU52850_1 Erysipelothrix rhusiopathiae 36 k (304 aa), FASTA score, opt: 287 E(): 6.9 [...]
Rv2060 protein networkhttps://string-db.org/network/83332.Rv2060Rv2060, (MTV019.01), len: 133 aa. Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-tr [...]
Rv2061c protein networkhttps://string-db.org/network/83332.Rv2061cConserved protein; Rv2061c, (MTV019.02c), len: 134 aa. Conserved protein. Similar to many. Contains IPR019965 F420-dependent enzyme, PPOX class, family Rv2061, domain. A core mycobacterial gene; [...]
cobN protein networkhttps://string-db.org/network/83332.Rv2062cRv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many.
mazE7 protein networkhttps://string-db.org/network/83332.Rv2063Antitoxin MazE7; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli but not in M.smegmatis neutralizes the effect of cognate toxin MazF7.
mazF7 protein networkhttps://string-db.org/network/83332.Rv2063APossible toxin MazF7; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralize [...]
cobG protein networkhttps://string-db.org/network/83332.Rv2064Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein.
cobH protein networkhttps://string-db.org/network/83332.Rv2065Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate.
cobI protein networkhttps://string-db.org/network/83332.Rv2066Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
Rv2067c protein networkhttps://string-db.org/network/83332.Rv2067cConserved protein; Rv2067c, (MTCY49.06c), len: 407 aa. Conserved protein, similar to many.
blaC protein networkhttps://string-db.org/network/83332.Rv2068cClass a beta-lactamase BlaC; Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta- lactam ring. Displays high levels of peni [...]
sigC protein networkhttps://string-db.org/network/83332.Rv2069RNA polymerase sigma factor, ECF subfamily, SigC; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytop [...]
cobK protein networkhttps://string-db.org/network/83332.Rv2070cPrecorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
cobM protein networkhttps://string-db.org/network/83332.Rv2071cPrecorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5.
cobL protein networkhttps://string-db.org/network/83332.Rv2072cPrecorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X.
Rv2073c protein networkhttps://string-db.org/network/83332.Rv2073cProbable shortchain dehydrogenase; Rv2073c, (MTCY49.12c), len: 249 aa. Probable oxidoreductase, belonging to shortchain dehydrogenase reductase (SDR) family, similar to many; Belongs to the short [...]
Rv2074 protein networkhttps://string-db.org/network/83332.Rv2074F420H(2)-dependent biliverdin reductase; Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalp [...]
Rv2075c protein networkhttps://string-db.org/network/83332.Rv2075cRv2075c, (MTCY49.14c), len: 487 aa. Possibly exported or envelope protein; has potential signal peptide at N-terminus and hydrophobic stretch around residue 430. Predicted to be an outer membrane [...]
Rv2076c protein networkhttps://string-db.org/network/83332.Rv2076cRv2076c, (MTCY49.15c), len: 83 aa. Conserved hypothetical protein, similar to many.
Rv2077A protein networkhttps://string-db.org/network/83332.Rv2077ARv2077A, len: 99 aa. Conserved hypothetical protein,similar to many.
Rv2077c protein networkhttps://string-db.org/network/83332.Rv2077cRv2077c, (MTCY49.16c), len: 323 aa. Possible conserved transmembrane protein. Part of Mycobacterium tuberculosis protein family with Rv2542, Rv2079, Rv2797c,Rv0963c, Rv1949c. Hydrophobic stretche [...]
Rv2078 protein networkhttps://string-db.org/network/83332.Rv2078Rv2078, (MTCY49.17), len: 104 aa. Conserved hypothetical protein, similar to many.
Rv2079 protein networkhttps://string-db.org/network/83332.Rv2079Rv2079, (MTCY49.18), len: 656 aa. Conserved hypothetical protein; part of Mycobacterium tuberculosis protein family with Rv2542, Rv2077c, Rv2797c, Rv0963c,Rv1949c. Contains PS00120 Lipases, serin [...]
lppJ protein networkhttps://string-db.org/network/83332.Rv2080Lipoprotein LppJ; Rv2080, (MTCY49.19), len: 187 aa. LppJ, lipoprotein; contains prokayotic lipoprotein modification site (PS00013) and signal sequence at N-terminus.
Rv2081c protein networkhttps://string-db.org/network/83332.Rv2081cRv2081c, (MTCY49.20c), len: 146 aa. Conserved transmembrane protein, similar to many. Hydrophobic stretch from aa 32-54.
Rv2082 protein networkhttps://string-db.org/network/83332.Rv2082Rv2082, (MTCY49.21), len: 721 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis Rv0029, and to Rv3899c and Rv3900c which may be frameshifted.
Rv2083 protein networkhttps://string-db.org/network/83332.Rv2083Rv2083, (MTCY49.22), len: 314 aa. Conserved hypothetical protein. Similar to many e.g. Mycobacterium tuberculosis Rv3898c (110 aa) and Rv3897c (210 aa).
Rv2084 protein networkhttps://string-db.org/network/83332.Rv2084Hypothetical protein; Rv2084, (MTCY49.23), len: 378 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv2085 protein networkhttps://string-db.org/network/83332.Rv2085Rv2085, (MTCY49.24), len: 101 aa. Conserved hypothetical protein, similar to but shorter than many transposases but we can find no sequence errors to account for the frameshifts. Contains possibl [...]
Rv2086 protein networkhttps://string-db.org/network/83332.Rv2086Rv2086, (MTCY49.25), len: 201 aa. Conserved hypothetical protein, similarity to but shorter than many transposases but we can find no sequence errors to account for the frameshifts. Start changed [...]
Rv2087 protein networkhttps://string-db.org/network/83332.Rv2087Rv2087, (MTCY49.27), len: 76 aa. Conserved hypothetical protein, similar to but shorter than transposases, but we can find no sequence errors to account for the frameshifts. Start changed since f [...]
pknJ protein networkhttps://string-db.org/network/83332.Rv2088Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J); In vitro, phosphorylates various substrates such as EmbR, PepE, MmaA4, Pyk, LldD and GroEL2.
pepE protein networkhttps://string-db.org/network/83332.Rv2089cDipeptidase PepE; Rv2089c, (MTCY49.29c), len: 375 aa. PepE,dipeptidase, similar to many; contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tubercu [...]
Rv2090 protein networkhttps://string-db.org/network/83332.Rv2090Probable 5'-3' exonuclease; 5'-3' exonuclease acting preferentially on double-stranded DNA.
Rv2091c protein networkhttps://string-db.org/network/83332.Rv2091cProbable membrane protein; Rv2091c, (MTCY49.31c), len: 244 aa. Probable membrane protein; contains potential transmembrane region. Repetitive ORF. A core mycobacterial gene; conserved in mycobact [...]
helY protein networkhttps://string-db.org/network/83332.Rv2092cRv2092c, (MTCY49.32c), len: 906 aa. HelY,ATP-dependent DNA helicase, similar to many; contains PS00017 ATP/GTP-binding site motif A, PS00402 Binding-protein-dependent transport systems inner memb [...]
tatC protein networkhttps://string-db.org/network/83332.Rv2093cSec-independent protein translocase transmembrane protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- argini [...]
tatA protein networkhttps://string-db.org/network/83332.Rv2094cSec-independent protein translocase membrane-bound protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- argin [...]
pafC protein networkhttps://string-db.org/network/83332.Rv2095cProteasome accessory factor C PafC; Part of the pafABC operon, but PafC does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistance to [...]
pafB protein networkhttps://string-db.org/network/83332.Rv2096cProteasome accessory factor B PafB; Part of the pafABC operon, however PafB does not seem to be involved in pupylation or substrate degradation. Appears to play at least a small role in resistanc [...]
pafA protein networkhttps://string-db.org/network/83332.Rv2097cProteasome accessory factor a PafA; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for prot [...]
PE_PGRS36 protein networkhttps://string-db.org/network/83332.Rv2098cPE-PGRS family protein PE_PGRS36; Rv2098c, (MTCY49.38c), len: 434 aa. PE_PGRS36,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Frame [...]
PE21 protein networkhttps://string-db.org/network/83332.Rv2099cRv2099c, (MTCY49.39c), len: 58 aa. PE21, Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002); 5'-end of Rv2098c|PE_PGRS36|MTCY49.38c, then frameshifts. Sequence has [...]
Rv2100 protein networkhttps://string-db.org/network/83332.Rv2100Rv2100, (MTCY49.40), len: 550 aa. Conserved hypothetical protein. Member of Mycobacterium tuberculosis REP13E12 repeat family with Rv1148c, Rv1945, Rv3467,Rv0094c, Rv1128c, Rv1587c, Rv1702c, Rv34 [...]
helZ protein networkhttps://string-db.org/network/83332.Rv2101Probable helicase HelZ; Rv2101, (MTV020.01), len: 1013 aa. Probable helZ,helicase, similar to many. Nucleotide position 2361623 in the genome sequence has been corrected, A:C resulting in M462L.
Rv2102 protein networkhttps://string-db.org/network/83332.Rv2102Rv2102, (MTV020.02), len: 238 aa. Conserved hypothetical protein, similar to many. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
vapC37 protein networkhttps://string-db.org/network/83332.Rv2103cPossible toxin VapC37. Contains PIN domain; Probable toxic component of a type II toxin-antitoxin (TA) system. An RNase. Upon expression in M.smegmatis inhibits colony formation. The putative cog [...]
vapB37 protein networkhttps://string-db.org/network/83332.Rv2104cPossible antitoxin VapB37; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Its putative cognate toxin is VapC37.
Rv2105 protein networkhttps://string-db.org/network/83332.Rv2105Rv2105, (MTCY261.01), len: 108 aa. Putative transposase for IS6110 (fragment), identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion elem [...]
Rv2106 protein networkhttps://string-db.org/network/83332.Rv2106Probable transposase; Rv2106, (MTCY261.02), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described he [...]
PE22 protein networkhttps://string-db.org/network/83332.Rv2107Rv2107, (MTCY261.03), len: 98 aa. PE22, Member of mycobacterial PE family (see citation below). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
PPE36 protein networkhttps://string-db.org/network/83332.Rv2108Rv2108, (MTCY261.04), len: 243 aa. PPE36, Member of the Mycobacterium tuberculosis PE family: N-terminus is similar to N-terminal region of Mycobacterium tuberculosis PPE family proteins. A core [...]
prcA protein networkhttps://string-db.org/network/83332.Rv2109cProteasome alpha subunit PrcA; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave o [...]
prcB protein networkhttps://string-db.org/network/83332.Rv2110cProteasome beta subunit PrcB; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The M.tuberculosis proteasome is able to cleave ol [...]
pup protein networkhttps://string-db.org/network/83332.Rv2111cProkaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging syst [...]
dop protein networkhttps://string-db.org/network/83332.Rv2112cDeamidase of pup Dop; Specifically catalyzes the deamidation of the C-terminal glutamine of the prokaryotic ubiquitin-like protein Pup to glutamate, thereby rendering Pup competent for conjugatio [...]
Rv2113 protein networkhttps://string-db.org/network/83332.Rv2113Rv2113, (MTCY261.09), len: 397 aa. Probable integral membrane protein.
Rv2114 protein networkhttps://string-db.org/network/83332.Rv2114Conserved protein; Rv2114, (MTCY261.10), len: 207 aa. Conserved protein, similar to many.
mpa protein networkhttps://string-db.org/network/83332.Rv2115cMycobacterial proteasome ATPase Mpa; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May b [...]
lppK protein networkhttps://string-db.org/network/83332.Rv2116Rv2116, (MTCY261.12), len: 189 aa. LppK, conserved lipoprotein, similar to many. Contains N-terminal signal sequence and PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Some simil [...]
Rv2117 protein networkhttps://string-db.org/network/83332.Rv2117Rv2117, (MTCY261.13), len: 97 aa. Conserved hypothetical protein, similar to many.
trmI protein networkhttps://string-db.org/network/83332.Rv2118cRNA methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
Rv2119 protein networkhttps://string-db.org/network/83332.Rv2119Rv2119, (MTCY261.15), len: 278 aa. Conserved hypothetical protein, similar to many.
Rv2120c protein networkhttps://string-db.org/network/83332.Rv2120cRv2120c, (MTCY261.16c), len: 160 aa. Probable conserved integral membrane protein, similar to many.
hisG protein networkhttps://string-db.org/network/83332.Rv2121cATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the [...]
hisE protein networkhttps://string-db.org/network/83332.Rv2122cPhosphoribosyl-AMP pyrophosphatase HisE; Rv2122c, (MTCY261.18), len: 93 aa. HisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (see citation below), similar to many. Note that pr [...]
PPE37 protein networkhttps://string-db.org/network/83332.Rv2123Rv2123, (MTCY261.19), len: 473 aa. PPE37 (alternate gene name: irg2), member of the Mycobacterium tuberculosis PPE family of proteins but the C-terminus is not repetitive (see citation below).
metH protein networkhttps://string-db.org/network/83332.Rv2124cMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor us [...]
Rv2125 protein networkhttps://string-db.org/network/83332.Rv2125Rv2125, (MTCY261.21), len: 292 aa. Conserved hypothetical protein, similar to many.
PE_PGRS37 protein networkhttps://string-db.org/network/83332.Rv2126cPE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tube [...]
ansP1 protein networkhttps://string-db.org/network/83332.Rv2127Rv2127, (MTCY261.26), len: 489 aa. AnsP1,L-asparagine permease, integral membrane protein similar to many. Contains PS00218 Amino acid permeases signature. Seems to belong to the APC family.
Rv2128 protein networkhttps://string-db.org/network/83332.Rv2128Rv2128, (MTCY26.27), len: 67 aa. Conserved transmembrane protein, similar to many.
Rv2129c protein networkhttps://string-db.org/network/83332.Rv2129cRv2129c, (MTCY261.28), len: 293 aa. Probable oxidoreductase, similar to many e.g. FABG_SYNY3|P73826 3-oxoacyl-[acyl-carrier protein] reductase (240 aa), FASTA scores: opt: 241, E(): 5.1e-17, (32. [...]
mshC protein networkhttps://string-db.org/network/83332.Rv2130cCysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoa [...]
cysQ protein networkhttps://string-db.org/network/83332.Rv2131cMonophosphatase CysQ; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulf [...]
Rv2132 protein networkhttps://string-db.org/network/83332.Rv2132Rv2132, (MTCY270.36c), len: 76 aa. Conserved hypothetical protein. Function unknown but belongs to Mycobacterium tuberculosis protein family including Rv2871,Rv1241, Rv3321c, Rv1113, Rv0657c, Rv1 [...]
Rv2133c protein networkhttps://string-db.org/network/83332.Rv2133cRv2133c, (MTCY270.35), len: 262 aa. Conserved hypothetical protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49774. FASTA best: Q49774 B2126_C1_150 (262 aa) [...]
Rv2134c protein networkhttps://string-db.org/network/83332.Rv2134cConserved protein; Rv2134c, (MTCY270.34), len: 195 aa. Conserved protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49789. FASTA best: Q49789 B2126_C3_228, o [...]
Rv2135c protein networkhttps://string-db.org/network/83332.Rv2135cConserved protein; Rv2135c, (MTCY270.33), len: 236 aa. Conserved protein. Function: unknown but equivalent to hypothetical Mycobacterium leprae protein, Q49773. FASTA best: Q49773 B2126_C1_148 op [...]
uppP protein networkhttps://string-db.org/network/83332.Rv2136cPossible conserved transmembrane protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Rv2137c protein networkhttps://string-db.org/network/83332.Rv2137cRv2137c, (MTCY270.31), len: 137 aa. Conserved hypothetical protein. C-terminus is very similar to hypothetical Mycobacterium leprae protein B2126_C2_188 (150 aa). FASTA best: Q49782 B2126_C2_188. [...]
lppL protein networkhttps://string-db.org/network/83332.Rv2138Rv2138, (MTCY270.30c), len: 358 aa. Probable lppL,conserved lipoprotein, with appropriately placed lipoprotein signature (PS00013) strongly similar to hypothetical Mycobacterium leprae protein, Q [...]
pyrD protein networkhttps://string-db.org/network/83332.Rv2139Probable dihydroorotate dehydrogenase PyrD; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
TB18.6 protein networkhttps://string-db.org/network/83332.Rv2140cConserved protein TB18.6; Rv2140c, (MTCY270.28), len: 176 aa. TB18.6,conserved protein; shows good similarity to hypothetical proteins from Streptomyces coelicolor (177 aa; 58% identity) >emb|CAC [...]
Rv2141c protein networkhttps://string-db.org/network/83332.Rv2141cConserved protein; Rv2141c, (MTCY270.27), len: 448 aa. Conserved protein. Shows some similarity to conserved hypothetical proteins and to acetylornithine deacetylase and succinyl-diaminopimelate [...]
parD2 protein networkhttps://string-db.org/network/83332.Rv2142APossible antitoxin ParD2; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin ParE2.
parE2 protein networkhttps://string-db.org/network/83332.Rv2142cPossible toxin ParE2; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpressio [...]
Rv2143 protein networkhttps://string-db.org/network/83332.Rv2143Rv2143, (MTCY270.25c), len: 352 aa. Conserved hypothetical protein, strongly similar to two hypothetical mycobacterial proteins Rv2030c 2.1e-50 and Rv0571c from position 120 (Q50819; Q50111). FAS [...]
Rv2144c protein networkhttps://string-db.org/network/83332.Rv2144cRv2144c, (MTCY270.24), len: 118 aa. Probable transmembrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
wag31 protein networkhttps://string-db.org/network/83332.Rv2145cDiviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress [...]
Rv2146c protein networkhttps://string-db.org/network/83332.Rv2146cRv2146c, (MTCY270.22), len: 96 aa. Possible conserved transmembrane protein, orthologs present in M. leprae, ML0921 (96 aa) and Streptomyces coelicolor. Second start taken GTG alternative upstrea [...]
sepF protein networkhttps://string-db.org/network/83332.Rv2147cConserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-li [...]
Rv2148c protein networkhttps://string-db.org/network/83332.Rv2148cConserved protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
yfiH protein networkhttps://string-db.org/network/83332.Rv2149cConserved protein YfiH; Multicopper oxidase with polyphenol oxidase activity.
ftsZ protein networkhttps://string-db.org/network/83332.Rv2150cCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the tim [...]
ftsQ protein networkhttps://string-db.org/network/83332.Rv2151cPossible cell division protein FtsQ; Essential cell division protein.
murC protein networkhttps://string-db.org/network/83332.Rv2152cProbable UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family.
murG protein networkhttps://string-db.org/network/83332.Rv2153cUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide [...]
ftsW protein networkhttps://string-db.org/network/83332.Rv2154cFtsW-like protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.
murD protein networkhttps://string-db.org/network/83332.Rv2155cProbable UDP-N-acetylmuramoylalanine-D-glutamate ligase MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to [...]
murX protein networkhttps://string-db.org/network/83332.Rv2156cProbable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.
murF protein networkhttps://string-db.org/network/83332.Rv2157cProbable UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase MurF; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramo [...]
murE protein networkhttps://string-db.org/network/83332.Rv2158cProbable UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase MurE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glu [...]
Rv2159c protein networkhttps://string-db.org/network/83332.Rv2159cConserved protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activi [...]
Rv2160A protein networkhttps://string-db.org/network/83332.Rv2160ARv2160A, len: 211 aa. Conserved hypothetical protein, possibly a TetR-family transcriptional regulator,similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c putative TetR-family transcriptio [...]
Rv2160c protein networkhttps://string-db.org/network/83332.Rv2160cRv2160c, (MTCY270.08), len: 113 aa. Conserved hypothetical protein, possibly a TetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c putative TetR-fami [...]
Rv2161c protein networkhttps://string-db.org/network/83332.Rv2161cConserved protein; Rv2161c, (MTCY270.07), len: 288 aa. Conserved protein; shows some similarity to protein involved in lincomycin production and to other M. tuberculosis proteins e.g. Rv0953c, Rv [...]
PE_PGRS38 protein networkhttps://string-db.org/network/83332.Rv2162cPE-PGRS family protein PE_PGRS38; Rv2162c, (MTCY270.06), len: 532 aa. PE_PGRS38,Member of M. tuberculosis PE_PGRS family (see citations below). FASTA score: Y03A_MYCTU Q 10637 hypothetical glycin [...]
pbpB protein networkhttps://string-db.org/network/83332.Rv2163cProbable penicillin-binding membrane protein PbpB; Synthesis of cross-linked peptidoglycan from the lipid intermediates; Belongs to the transpeptidase family.
Rv2164c protein networkhttps://string-db.org/network/83332.Rv2164cRv2164c, (MTCY270.04), len: 384 aa. Probable pro-rich conserved membrane protein, equivalent to ML0907|AL022602 putative conserved membrane protein from Mycobacterium leprae (377 aa) (AL022602), [...]
rsmH protein networkhttps://string-db.org/network/83332.Rv2165cConserved protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA; Belongs to the methyltransferase superfamily. RsmH family.
mraZ protein networkhttps://string-db.org/network/83332.Rv2166cConserved protein; Rv2166c, (MTCY270.02), len: 143 aa. Conserved protein; shows strong similarity to several hypothetical bacterial proteins such as YLLB_BACSU P55343. Is equivalent to Mycobacter [...]
Rv2167c protein networkhttps://string-db.org/network/83332.Rv2167cProbable transposase; Rv2167c, (MTCY270.01), len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be m [...]
Rv2168c protein networkhttps://string-db.org/network/83332.Rv2168cRv2168c, (MTV021.01c), len: 108 aa. Putative transposase for IS6110 (fragment), identical to many other Mycobacterium tuberculosis IS6110 transposase subunits e.g. Q50686|YIA4_MYCTU Insertion ele [...]
Rv2169c protein networkhttps://string-db.org/network/83332.Rv2169cRv2169c, (MTV021.02c), len: 134 aa. Probable conserved transmembrane protein, with orthologs in M. leprae, ML0904 probable membrane protein (134 aa), and Streptomyces coelicolor. FASTA scores wit [...]
Rv2170 protein networkhttps://string-db.org/network/83332.Rv2170GCN5-related N-acetyltransferase; Rv2170, (MTV021.03), len: 206 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 2005 [...]
lppM protein networkhttps://string-db.org/network/83332.Rv2171Probable conserved lipoprotein LppM; A putative lipoprotein that seems to be specialized for the initial steps of macrophage infection. A non-acylated fragment (residues 26-185) binds phosphatidy [...]
Rv2172c protein networkhttps://string-db.org/network/83332.Rv2172cConserved protein; Rv2172c, (MTV021.05c), len: 301 aa. Conserved protein, equivalent to Mycobacterium leprae conserved hypothetical protein ML0901 (304 aa). FASTA scores: opt: 1656, E(): 7.7e-98; [...]
idsA2 protein networkhttps://string-db.org/network/83332.Rv2173Rv2173, (MTV021.06), len: 352 aa. Probable idsA2,geranylgeranyl pyrophosphate synthase, similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Conta [...]
mptA protein networkhttps://string-db.org/network/83332.Rv2174Alpha(1->6)mannosyltransferase. Possible conserved integral membrane protein; Involved in the latter stages of the biosynthesis of the alpha-(1->6) mannan core of lipomannan (LM). Catalyzes the a [...]
Rv2175c protein networkhttps://string-db.org/network/83332.Rv2175cConserved regulatory protein; Binds DNA at low salt concentrations.
pknL protein networkhttps://string-db.org/network/83332.Rv2176Probable transmembrane serine/threonine-protein kinase L PknL (protein kinase L) (STPK L); Phosphorylates the DNA-binding protein Rv2175c. May be involved in the regulation of cell division and c [...]
Rv2177c protein networkhttps://string-db.org/network/83332.Rv2177cPossible transposase; Rv2177c, (MTV021.10c), len: 221 aa. Possible IS1558 transposase (see citation below), similar to several is element proteins and transposases but nearly identical to last 22 [...]
aroG protein networkhttps://string-db.org/network/83332.Rv2178cPhospho-2-dehydro-3-deoxyheptonate aldolase AroG; Catalyzes an aldol-like condensation reaction between phosphoenolpyruvate (PEP) and D-erythrose 4-phosphate (E4P) to generate 3-deoxy-D-arabino-h [...]
Rv2179c protein networkhttps://string-db.org/network/83332.Rv2179cConserved hypothetical protein; Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA. Has no activity with 5' overhangs. Has negligible endonuclease activity. Can bind ATP [...]
Rv2180c protein networkhttps://string-db.org/network/83332.Rv2180cRv2180c, (MTV021.13c), len: 295 aa. Probable conserved integral membrane protein, similar to pir||T35292 probable integral membrane protein from Streptomyces coelicolor >gi|5578858|emb|CAB51260.1 [...]
Rv2181 protein networkhttps://string-db.org/network/83332.Rv2181Alpha(1->2)mannosyltransferase; Responsible for the addition of alpha-(1-2) mannose branches to the linear mannan core on the biosynthetic pathway to mature lipoarabinomannan (LAM).
Rv2182c protein networkhttps://string-db.org/network/83332.Rv2182cRv2182c, (MTV021.15c), len: 247 aa. Probable 1-acylglycerol-3-phosphate O-acyltransferase, similar to many e.g. in Streptomyces. Contains PS00017 ATP/GTP-binding site motif A (P-loop). FASTA scor [...]
Rv2183c protein networkhttps://string-db.org/network/83332.Rv2183cConserved protein; Rv2183c, (MTV021.16c), len: 131 aa. Conserved protein, equivalent to Mycobacterium leprae hypothetical protein ML0891 (MLCB268.25c, 130 aa). FASTA scores: opt: 558, E(): 8.3e-2 [...]
Rv2184c protein networkhttps://string-db.org/network/83332.Rv2184cRv2184c, (MTV021.17c), len: 379 aa. Conserved hypothetical protein, equivalent to hypothetical protein ML0890 (415 aa) from Mycobacterium leprae and also shows some similarity to other hypothetic [...]
TB16.3 protein networkhttps://string-db.org/network/83332.Rv2185cConserved protein TB16.3; Rv2185c, (MTV021.18c), len: 144 aa. TB16.3,conserved protein, similar to other hypothetical actinomycete proteins and equivalent to Mycobacterium leprae ML0889 (144 aa). [...]
Rv2186c protein networkhttps://string-db.org/network/83332.Rv2186cRv2186c, (MTV021.19c), len: 129 aa. Conserved hypothetical protein, equivalent to hypothetical Mycobacterium leprae protein ML0888 (135 aa). FASTA scores: ML0888 opt: 704, E(): 2.9e-43; 80.000% i [...]
fadD15 protein networkhttps://string-db.org/network/83332.Rv2187Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Catalyzes the activation of long-chain fatty acids as acyl- coenzyme A (acyl-CoA), which are then tr [...]
pimB protein networkhttps://string-db.org/network/83332.Rv2188cMannosyltransferase PimB; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM [...]
Rv2189c protein networkhttps://string-db.org/network/83332.Rv2189cRv2189c, (MTV021.22c), len: 257 aa. Conserved hypothetical protein; some similarity to hypothetical protein SC6G10.07c (385 aa) from Streptomyces coelicolor A3(2). Smith-Waterman scores: pir||T35 [...]
Rv2190c protein networkhttps://string-db.org/network/83332.Rv2190cConserved hypothetical protein; Rv2190c, (MTV021.23c, MTCY190.01c), len: 385 aa. Conserved hypothetical protein; similar to other hypothetical mycobacterial proteins, including Rv1477,Rv1478, Rv1 [...]
Rv2191 protein networkhttps://string-db.org/network/83332.Rv2191Rv2191, (MTCY190.02), len: 645 aa. Conserved hypothetical protein, similar to SW:DP3A_B ACSU P13267 DNA polymerase III, alpha chain (31.3% identity in 249 aa overlap) and SW:UVRC_ECOLI P07028 exc [...]
trpD protein networkhttps://string-db.org/network/83332.Rv2192cProbable anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribos [...]
ctaE protein networkhttps://string-db.org/network/83332.Rv2193Rv2193, (MTCY190.04), len: 203 aa. Probable ctaE,cytochrome c oxidase polypeptide III (cox3), with strong similarity to others e.g. COX3_SYNY3|Q06475 (29.8% identity in 225 aa overlap).
qcrC protein networkhttps://string-db.org/network/83332.Rv2194Probable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit); Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain requi [...]
qcrA protein networkhttps://string-db.org/network/83332.Rv2195Probable rieske iron-sulfur protein QcrA; Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 [...]
qcrB protein networkhttps://string-db.org/network/83332.Rv2196Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit); Cytochrome b subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain requi [...]
Rv2197c protein networkhttps://string-db.org/network/83332.Rv2197cRv2197c, (MTCY190.08c), len: 214 aa. Probable conserved transmembrane protein, equivalent to ML0878 conserved hypothetical protein (212 aa) of Mycobacterium leprae. FASTA scores: opt: 858; 62.559 [...]
mmpS3 protein networkhttps://string-db.org/network/83332.Rv2198cRv2198c, (MTCY190.09c), len: 299 aa. Probable mmpS3,conserved membrane protein (see citation below), equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa), FASTA [...]
ctaF protein networkhttps://string-db.org/network/83332.Rv2199cPossible conserved integral membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
ctaC protein networkhttps://string-db.org/network/83332.Rv2200cProbable transmembrane cytochrome C oxidase (subunit II) CtaC; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a a [...]
asnB protein networkhttps://string-db.org/network/83332.Rv2201Rv2201, (MTCY190.12), len: 652 aa. Probable asnB,asparagine synthetase, similar to e.g. SW:ASNH_BACSU P42113 putative asparagine synthetase (26.0% identity in 438 aa overlap).
adoK protein networkhttps://string-db.org/network/83332.Rv2202cAdenosine kinase; Catalyzes the phosphorylation of adenosine to adenosine monophosphate (AMP). Can also catalyze the phosphorylation of the adenosine analog 2-methyladenosine (methyl-Ado) to meth [...]
Rv2203 protein networkhttps://string-db.org/network/83332.Rv2203Rv2203, (MTCY190.14), len: 230 aa. Possible conserved membrane protein; has single hydrophobic stretch from aa 75 to 97 and is equivalent to Mycobacterium leprae ML0872 putative membrane protein [...]
Rv2204c protein networkhttps://string-db.org/network/83332.Rv2204cConserved protein; Rv2204c, (MTCY190.15c), len: 118 aa. Conserved protein. Similar to conserved hypothetical proteins in Actinomycetes and equivalent to Mycobacterium leprae ML0871|ML0871 conserv [...]
Rv2205c protein networkhttps://string-db.org/network/83332.Rv2205cRv2205c, (MTCY190.16c), len: 358 aa. Conserved hypothetical protein. Very similar to YHAD_ECOLI|P23524 hypothetical protein (YHAD (E.coli) / YXAA (S14A) (B.subtilis) family) (41.6% identity in 15 [...]
Rv2206 protein networkhttps://string-db.org/network/83332.Rv2206Rv2206, (MTCY190.17), len: 236 aa. Probable conserved transmembrane protein. Equivalent to hypothetical protein ML0869 (247 aa) of Mycobacterium leprae gZ98741|MLCB22_2 (247 aa), FASTA scores: op [...]
cobT protein networkhttps://string-db.org/network/83332.Rv2207Probable nicotinate-nucleotide-dimethylbenzimidazol phosphoribosyltransferase CobT; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbe [...]
cobS protein networkhttps://string-db.org/network/83332.Rv2208Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from [...]
Rv2209 protein networkhttps://string-db.org/network/83332.Rv2209Rv2209, (MTCY190.20), len: 512 aa. Probable conserved integral membrane protein, similar to but longer than Rv0246 gp|AL021929|MTV 034_12 Mycobacterium tuberculosis (436 aa). FASTA score: opt: 71 [...]
ilvE protein networkhttps://string-db.org/network/83332.Rv2210cBranched-chain amino acid transaminase IlvE; Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosyn [...]
gcvT protein networkhttps://string-db.org/network/83332.Rv2211cProbable aminomethyltransferase GcvT (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
Rv2212 protein networkhttps://string-db.org/network/83332.Rv2212Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase); Rv2212, (MTCY190.23), len: 378 aa. Adenylyl cyclase (See Abdel Motaal et al., 2006). Some similarity to e.g. SW:CYAA_STRCO P40135 a [...]
pepB protein networkhttps://string-db.org/network/83332.Rv2213Probable aminopeptidase PepB; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various pep [...]
ephD protein networkhttps://string-db.org/network/83332.Rv2214cRv2214c, (MTCY190.25c), len: 592 aa. Possible ephD,short-chain dehydrogenase (see citation below), equivalent to Z98741|MLCB22_8 Mycobacterium leprae cosmid B22; (596 aa), FASTA score: opt: 3262, [...]
dlaT protein networkhttps://string-db.org/network/83332.Rv2215DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl- [...]
Rv2216 protein networkhttps://string-db.org/network/83332.Rv2216Conserved protein; Rv2216, (MTCY190.27), len: 301 aa. Conserved protein, equivalent to Mycobacterium leprae ML0860 (307 aa), Z98741|MLCB22_10 Mycobacterium leprae cosmid B22; H (307 aa). FASTA sc [...]
lipB protein networkhttps://string-db.org/network/83332.Rv2217Probable lipoate biosynthesis protein B LipB; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzyme [...]
lipA protein networkhttps://string-db.org/network/83332.Rv2218Probable lipoate biosynthesis protein A LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lip [...]
Rv2219 protein networkhttps://string-db.org/network/83332.Rv2219Rv2219, (MTCY190.30), len: 250 aa. Probable conserved transmembrane protein. Equivalent to hypothetical membrane protein ML0857 (250 aa) from Mycobacterium leprae Z98741 |MLCB22_13 Mycobacterium [...]
Rv2219A protein networkhttps://string-db.org/network/83332.Rv2219ARv2219A, len: 140 aa. Probable conserved membrane protein, similar to SC3H12.05c|AL355740_5 possible integral membrane protein from Streptomyces coelicolor (155 aa),FASTA scores: opt: 327, E(): 7 [...]
glnA1 protein networkhttps://string-db.org/network/83332.Rv2220Glutamine synthetase GlnA1 (glutamine synthase) (GS-I); Involved in nitrogen metabolism via ammonium assimilation. Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia [...]
glnE protein networkhttps://string-db.org/network/83332.Rv2221cGlutamate-ammonia-ligase adenylyltransferase GlnE (glutamine-synthetase adenylyltransferase); Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate am [...]
glnA2 protein networkhttps://string-db.org/network/83332.Rv2222cProbable glutamine synthetase GlnA2 (glutamine synthase) (GS-II); Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chap [...]
caeB protein networkhttps://string-db.org/network/83332.Rv2223cProbable exported protease; Catalyzes the cleavage of ester bonds. Esterase activity increases with increasing carbon chain length of the substrate (Potential).
caeA protein networkhttps://string-db.org/network/83332.Rv2224cProbable carboxylesterase CaeA; Involved in virulence. Catalyzes the cleavage of ester bonds. Esterase activity increases with increasing carbon chain length of the substrate.
panB protein networkhttps://string-db.org/network/83332.Rv22253-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerat [...]
Rv2226 protein networkhttps://string-db.org/network/83332.Rv2226Conserved protein; Rv2226, (MTCY427.07), len: 513 aa. Conserved protein, similar to hypothetical secreted protein (510 aa) from Streptomyces coelicolor A3(2) emb|CAB59601.1| (AL132662) hypothetic [...]
Rv2227 protein networkhttps://string-db.org/network/83332.Rv2227Rv2227, (MTCY427.08), len: 233 aa. Conserved hypothetical protein, similar to conserved hypothetical proteins from various bacteria e.g. gb|AAK22693.1| (AE005746) conserved hypothetical protein f [...]
Rv2228c protein networkhttps://string-db.org/network/83332.Rv2228cMultifunctional protein. Has RNASE H,alpha-ribazole phosphatase, and acid phosphatase activities; Endonuclease that displays both RNase H activity with a hybrid RNA/DNA substrate as well as doubl [...]
Rv2229c protein networkhttps://string-db.org/network/83332.Rv2229cConserved protein; Rv2229c, (MTCY427.10c), len: 245 aa. Conserved protein; probable coiled-coil protein similar to conserved hypothetical proteins in Actinomycetes. Equivalent to Mycobacterium le [...]
Rv2230c protein networkhttps://string-db.org/network/83332.Rv2230cConserved protein; Rv2230c, (MTCY427.11c), len: 379 aa. Conserved protein. Equivalent to Mycobacterium leprae, ML1639,conserved hypothetical protein (385 aa). Similar to hypothetical proteins fro [...]
vapC16 protein networkhttps://string-db.org/network/83332.Rv2231APossible toxin VapC16; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB16 (By similarity). Belongs to the PINc/VapC protein family.
cobC protein networkhttps://string-db.org/network/83332.Rv2231cRv2231c, (MTCY427.12c), len: 364 aa. Possible cobC,aminotransferase. Note that initiation codon uncertain. Similar to CobC aminotransferases e.g. sp|P21633|COBC_PSEDE COBC protein (333 aa) opt: 2 [...]
ptkA protein networkhttps://string-db.org/network/83332.Rv2232Rv2232, (MTCY427.13), len: 291 aa. PtkA, protein tyrosine kinase, similar to members of haloacid dehalogenase-like family from several bacteria and to putative phosphatases e.g. Q9I767 and AAK783 [...]
ptpA protein networkhttps://string-db.org/network/83332.Rv2234Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase); Mediates host-pathogen interaction and interferes with vesicular trafficking in the infected ma [...]
Rv2235 protein networkhttps://string-db.org/network/83332.Rv2235Rv2235, (MTCY427.16), len: 271 aa. Probable conserved transmembrane protein (see Miller & Shinnick 2001); hydrophobic regions near N- and C-terminus. Similar to conserved membrane proteins in oth [...]
cobD protein networkhttps://string-db.org/network/83332.Rv2236cProbable cobalamin biosynthesis transmembrane protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
Rv2237 protein networkhttps://string-db.org/network/83332.Rv2237Conserved protein; Rv2237, (MTCY427.18), len: 255 aa. Conserved protein. Similar to Mycobacterium tuberculosis hypothetical proteins Rv0276, Rv0826, Rv1645c. FASTA score: Rv0276 gp|AL021930|MTV03 [...]
Rv2237A protein networkhttps://string-db.org/network/83332.Rv2237ARv2237A, len: 78 aa. Conserved protein.
ahpE protein networkhttps://string-db.org/network/83332.Rv2238cProbable peroxiredoxin AhpE; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell prote [...]
Rv2239c protein networkhttps://string-db.org/network/83332.Rv2239cRv2239c, (MTCY427.20c), len: 158 aa. Conserved hypothetical protein, similar to conserved hypothetical proteins from Mycobacterium leprae (ML1649, 140 aa) and Streptomyces coelicolor A3(2) (SCC8A [...]
Rv2240c protein networkhttps://string-db.org/network/83332.Rv2240cUnknown protein; Rv2240c, (MTCY427.21c), len: 196 aa. Unknown protein. Start changed since first submission (-69 aa).
aceE protein networkhttps://string-db.org/network/83332.Rv2241Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity [...]
Rv2242 protein networkhttps://string-db.org/network/83332.Rv2242Rv2242, (MTCY427.23), len: 414 aa. Conserved hypothetical protein. Equivalent to ML1652 conserved hypothetical protein from Mycobacterium leprae (414 aa),and orthologue in Streptomyces coelicolor [...]
fabD protein networkhttps://string-db.org/network/83332.Rv2243Rv2243, (MTCY427.24), len: 302 aa. FabD (alternate gene name: mtFabD), malonyl CoA-acyl carrier protein transacylase (see citations below), highly similar to e.g. A57356 acyl-CoA carrier protein [...]
acpM protein networkhttps://string-db.org/network/83332.Rv2244Meromycolate extension acyl carrier protein AcpM; Acyl carrier protein involved in meromycolate extension. Belongs to the acyl carrier protein (ACP) family.
kasA protein networkhttps://string-db.org/network/83332.Rv22453-oxoacyl-[acyl-carrier protein] synthase 1 KasA (beta-ketoacyl-ACP synthase) (KAS I); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbo [...]
kasB protein networkhttps://string-db.org/network/83332.Rv22463-oxoacyl-[acyl-carrier protein] synthase 2 KasB (beta-ketoacyl-ACP synthase) (KAS I); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbo [...]
accD6 protein networkhttps://string-db.org/network/83332.Rv2247Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6; Rv2247, (MTCY427.28), len: 473 aa. AccD6,Acetyl/Propionyl CoA Carboxylase, beta subunit (see citations below), highly similar to e.g. PCCB_R [...]
Rv2248 protein networkhttps://string-db.org/network/83332.Rv2248Rv2248, (MTCY427.29), len: 271 aa. Conserved hypothetical protein. Very similar to hypothetical M. tuberculosis proteins Rv3517, Rv1482c, Rv3555c, Rv3714c,Rv1073. FASTA score: MTCY06G11.02c MTCY6 [...]
glpD1 protein networkhttps://string-db.org/network/83332.Rv2249cRv2249c, (MTCY427.31c), len: 516 aa. Probable glpD1,glycerol-3-phosphate dehydrogenase, similar to SW:GLPD_ECOLI P13035 aerobic glycerol-3-phosphate dehydrogenase (30.0% identity in 486 aa overla [...]
Rv2250A protein networkhttps://string-db.org/network/83332.Rv2250APossible flavoprotein; Rv2250A, len: 139 aa. Conserved hypothetical protein, possibly flavoprotein. Similar to N-terminus of SCF91.28c|AL132973_28 possible flavoprotein from Streptomyces coelicol [...]
Rv2250c protein networkhttps://string-db.org/network/83332.Rv2250cRv2250c, (MTCY427.32c), len: 189 aa. Possible transcriptional regulatory protein, TetR family. Start unclear; ORF has been shortened since first submission to avoid overlap with Rv2251 (-30 aa). [...]
Rv2251 protein networkhttps://string-db.org/network/83332.Rv2251Rv2251, (MTV022.01), len: 475 aa. Possible flavoprotein, probably continuation of Rv2250A, similar to MTCY164.18 from Mycobacterium tuberculosis and to several alkyldihydroxyacetonephosphate synt [...]
dagK protein networkhttps://string-db.org/network/83332.Rv2252Diacylglycerol kinase; Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is involved in the biosynthesis of phosphatidylinositol mannosides (PIMs), probably via a role [...]
Rv2253 protein networkhttps://string-db.org/network/83332.Rv2253Rv2253, (MTV022.03), len: 167 aa. Possible secreted protein; has potential N-terminal signal peptide. Predicted to be an outer membrane protein (See Song et al., 2008).
Rv2254c protein networkhttps://string-db.org/network/83332.Rv2254cRv2254c, (MTV022.04c), len: 151 aa. Probable integral membrane protein.
Rv2255c protein networkhttps://string-db.org/network/83332.Rv2255cHypothetical protein; Rv2255c, (MTV022.05c), len: 64 aa. Hypothetical unknown protein.
Rv2256c protein networkhttps://string-db.org/network/83332.Rv2256cRv2256c, (MTV022.06c), len: 177 aa. Conserved hypothetical protein, similar to Streptomyces glaucescens ORF5 (164 aa) and Streptomyces coelicolor hypothetical protein SC4A7.19c (164 aa; emb|CAB62 [...]
Rv2257c protein networkhttps://string-db.org/network/83332.Rv2257cConserved protein; Rv2257c, (MTV022.07c), len: 272 aa. Conserved protein, similar to hypothetical protein SC4A7.08 from Streptomyces coelicolor (273 aa; 58% identity in 243 aa overlap). Also simi [...]
Rv2258c protein networkhttps://string-db.org/network/83332.Rv2258cRv2258c, (MTV022.08c), len: 353 aa. Possible transcriptional regulatory protein, similar to several hypothetical proteins from C. elegans. FASTA scores: sptr|O01593|O01593 coded for by C. elegans [...]
mscR protein networkhttps://string-db.org/network/83332.Rv2259Rv2259, (MTV022.09), len: 361 aa. MscR,S-nitrosomycothiol reductase (see Vogt et al., 2003),similar to several zinc-containing alcohol dehydrogenases especially from Amycolatopsis methanolica P80 [...]
Rv2260 protein networkhttps://string-db.org/network/83332.Rv2260Rv2260, (MTV022.10), len: 211 aa. Conserved hypothetical protein, similar to hypothetical proteins Rv0634c, Rv1637c, Rv3677c, Rv2581c from Mycobacterium tuberculosis and to various hydrolases. FA [...]
Rv2261c protein networkhttps://string-db.org/network/83332.Rv2261cRv2261c, (MTV022.11c), len: 140 aa. Conserved hypothetical protein, with function unknown but some similarity to C-terminal end of PCC6803 apolipoprotein N-acyltransferase from Synechocystis sp. [...]
Rv2262c protein networkhttps://string-db.org/network/83332.Rv2262cConserved hypothetical protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Rv2263 protein networkhttps://string-db.org/network/83332.Rv2263Rv2263, (MTV022.13), len: 317 aa. Possible oxidoreductase, similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q5440 [...]
Rv2264c protein networkhttps://string-db.org/network/83332.Rv2264cRv2264c, (MTV022.14c), len: 592 aa. Conserved hypothetical Pro-rich protein, similar to hypothetical proteins Rv0312 (MTCY63.17, 620 aa and Rv0350) that has highly Pro-, Thr-rich C-terminus. Cont [...]
Rv2265 protein networkhttps://string-db.org/network/83332.Rv2265Rv2265, (MTCY339.45c), len: 409 aa. Possible conserved integral membrane protein, with some similarity to others e.g. M. thermoauto. sp|O26855|O26855 conserved protein (383 aa), FASTA score: opt: [...]
cyp124 protein networkhttps://string-db.org/network/83332.Rv2266Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and [...]
stf3 protein networkhttps://string-db.org/network/83332.Rv2267cConserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulen [...]
cyp128 protein networkhttps://string-db.org/network/83332.Rv2268cRv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, [...]
Rv2269c protein networkhttps://string-db.org/network/83332.Rv2269cHypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
lppN protein networkhttps://string-db.org/network/83332.Rv2270Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human).
Rv2271 protein networkhttps://string-db.org/network/83332.Rv2271Rv2271, (MTCY339.39c), len: 99 aa. Conserved hypothetical protein; some similarity to hypothetical protein AAK01340.1|AF265275_3 (AF265275) from uncultured organism Pu8 (104 aa) E= 4e-10, (34% id [...]
Rv2272 protein networkhttps://string-db.org/network/83332.Rv2272Rv2272, (MTCY339.38c), len: 122 aa. Probable conserved transmembrane protein, similar to YIDH_ECOLI P31445 hypothetical 12.8 kDa protein (115 aa), FASTA scores, opt: 291, E(): 2.9e-14, (45.6% ide [...]
Rv2273 protein networkhttps://string-db.org/network/83332.Rv2273Rv2273, (MTCY339.37c), len: 109 aa. Probable conserved transmembrane protein, similar to Rv2272 (MTCY339.38c), (35.0% identity in 100 aa overlap).
mazE8 protein networkhttps://string-db.org/network/83332.Rv2274APossible antitoxin MazE8; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is MazF8.
mazF8 protein networkhttps://string-db.org/network/83332.Rv2274cPossible toxin MazF8; Putative toxic component of a type II toxin-antitoxin (TA) system, its cognate toxin is MaZE8. Probably an endoribonuclease (By similarity).
Rv2275 protein networkhttps://string-db.org/network/83332.Rv2275Conserved hypothetical protein; Involved in the biosynthesis of mycocyclosin. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent [...]
cyp121 protein networkhttps://string-db.org/network/83332.Rv2276Cytochrome P450 121 Cyp121; Catalyzes C-C bond formation between the carbons ortho to the phenolic hydroxyl of cyclo(L-tyr-L-tyr) (cYY) producing mycocyclosin. Can also use cyclo(L-Tyr-L-Phe) (cY [...]
Rv2277c protein networkhttps://string-db.org/network/83332.Rv2277cRv2277c, (MTCY339.33), len: 301 aa. Possible glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa), FASTA scores, opt: 149, [...]
Rv2278 protein networkhttps://string-db.org/network/83332.Rv2278Rv2278, (MTCY339.32c), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by [...]
Rv2279 protein networkhttps://string-db.org/network/83332.Rv2279Probable transposase; Rv2279, (MTCY339.31c), len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be m [...]
Rv2280 protein networkhttps://string-db.org/network/83332.Rv2280Rv2280, (MTCY339.30c), len: 459 aa. Probable dehydrogenase. Similar to D-lactate dehydrogenase (cytochrome) precursor e.g. G1061264 (587 aa), FASTA scores, opt: 645,E(): 1.3e-31, (28.0% identity [...]
pitB protein networkhttps://string-db.org/network/83332.Rv2281Putative phosphate-transport permease PitB; Potential transporter for phosphate.
Rv2282c protein networkhttps://string-db.org/network/83332.Rv2282cRv2282c, (MTCY339.28), len: 312 aa. Probable transcriptional regulator, lysR family, similar to others e.g. YC30_CYAPA|P48271 hypothetical transcriptional regulator YCF30 (324 aa), FASTA scores: [...]
Rv2283 protein networkhttps://string-db.org/network/83332.Rv2283Hypothetical protein; Rv2283, (MTCY339.27c), len: 64 aa. Unknown protein; questionable ORF.
lipM protein networkhttps://string-db.org/network/83332.Rv2284Probable esterase LipM; Rv2284, (MTCY339.26c), len: 431 aa. Probable lipM,esterase, similar to others e.g. gp|Z95844|MTCY493_28 from Mycobacterium tuberculosis cosmid (420 aa), FASTA scores: opt: [...]
Rv2285 protein networkhttps://string-db.org/network/83332.Rv2285Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
Rv2286c protein networkhttps://string-db.org/network/83332.Rv2286cRv2286c, (MTCY339.24), len: 230 aa. Conserved hypothetical protein. Similar to Mycobacterium tuberculosis hypothetical protein, Rv2466c, AL021246|MTV008_22 (207 aa). FASTA score: opt: 324, E(): 8 [...]
yjcE protein networkhttps://string-db.org/network/83332.Rv2287Rv2287, (MTCY339.23c), len: 542 aa. Probable yjcE,conserved integral membrane transport protein, similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger [...]
Rv2288 protein networkhttps://string-db.org/network/83332.Rv2288Hypothetical protein; Rv2288, (MTCY339.22c), len: 125 aa. Unknown hypothetical protein.
cdh protein networkhttps://string-db.org/network/83332.Rv2289Rv2289, (MTCY339.21c), len: 260 aa. Probable cdh,CDP-diacylglycerol pyrophosphatase, similar to CDH_SALTY|P26219 cdp-diacylglycerol pyrophosphatase (251 aa), FASTA scores: opt: 395, E(): 5.9e-20, [...]
lppO protein networkhttps://string-db.org/network/83332.Rv2290Rv2290, (MTCY339.20c), len: 171 aa. Probable lppO,conserved lipoprotein, similar to Rv3763, 19KD_MYCTU P11572 19 kDa lipoprotein antigen precursor (159 aa) FASTA scores,opt: 119, E (): 1.3, (25.6 [...]
sseB protein networkhttps://string-db.org/network/83332.Rv2291Rv2291, (MTCY339.19c), len: 284 aa. Probable sseB,thiosulfate sulfurtransferase. Very similar to thiosulfate sulfurtransferas/rhodanese from Streptomyces coelicolor AL00920 4|SC9B10_21 (283 aa) o [...]
Rv2292c protein networkhttps://string-db.org/network/83332.Rv2292cHypothetical protein; Rv2292c, (MTCY339.18), len: 74 aa. Unknown hypothetical protein.
Rv2293c protein networkhttps://string-db.org/network/83332.Rv2293cRv2293c, (MTCY339.17), len: 246 aa. Conserved hypothetical protein; some similarity to hypothetical protein (299 aa) AAK24237.1| (AE005897) belonging to phosphorylase family [Caulobacter crescent [...]
Rv2294 protein networkhttps://string-db.org/network/83332.Rv2294Rv2294, (MTCY339.16c), len: 407 aa. Probable aminotransferase, similar to others in M. tuberculosis e.g. MTV030_19, also similar to PATB_BACSU|Q08432 putative aminotransferase b from Bacillus sub [...]
Rv2295 protein networkhttps://string-db.org/network/83332.Rv2295Conserved hypothetical protein; Probably plays a role in host phagosome maturation arrest ; Belongs to the UPF0167 family.
dhmA1 protein networkhttps://string-db.org/network/83332.Rv2296Probable haloalkane dehalogenase; Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide [...]
Rv2297 protein networkhttps://string-db.org/network/83332.Rv2297Unknown protein; Rv2297, (MTCY339.13c), len: 150 aa. Unknown protein; contains PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide.
Rv2298 protein networkhttps://string-db.org/network/83332.Rv2298Conserved protein; Rv2298, (MTCY339.12c), len: 323 aa. Conserved protein. Similar to SLR0545 Synechocystis sp, Q55493 hypothetical 34.6 kDa protein (314 aa), FASTA scores, opt: 427, E(): 1.7e-20, [...]
htpG protein networkhttps://string-db.org/network/83332.Rv2299cChaperone protein HtpG; Molecular chaperone. Has ATPase activity.
Rv2300c protein networkhttps://string-db.org/network/83332.Rv2300cConserved protein; Rv2300c, (MTCY339.09), len: 310 aa (start uncertain). Conserved protein, similar to others e.g. Q9RXY2|DR0172 conserved hypothetical protein from Deinococcus radiodurans (271 a [...]
cut2 protein networkhttps://string-db.org/network/83332.Rv2301Probable cutinase Cut2; Rv2301, (MTCY339.08c), len: 230 aa. Probable cut2 (alternate gene name: cfp25), cutinase, highly similar to others from Mycobacteria tuberculosis e.g. MTCY13E12.04|Rv3451| [...]
Rv2302 protein networkhttps://string-db.org/network/83332.Rv2302Conserved protein; Rv2302, (MTCY339.07c), len: 80 aa. Conserved protein, highly similar to others: O53766|AL021942|Rv0569|MTV039.07 hypothetical 9.5 KDA protein from Mycobacterium tuberculosis (8 [...]
Rv2303c protein networkhttps://string-db.org/network/83332.Rv2303cRv2303c, (MTCY339.06, MT2360), len: 307 aa. Probable antibiotic-resistance protein, with some similarity to Q54229|G153373 macrotetrolide antibiotic-resistance protein (NONR) from Streptomyces gr [...]
Rv2304c protein networkhttps://string-db.org/network/83332.Rv2304cHypothetical protein; Rv2304c, (MTCY339.05), len: 69 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv2305 protein networkhttps://string-db.org/network/83332.Rv2305Unknown protein; Rv2305, (MTCY339.04c), len: 429 aa. Unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv2306A protein networkhttps://string-db.org/network/83332.Rv2306ARv2306A, len: 197 aa. Possible conserved membrane protein, similar to several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor, e.g. Rv0625c|P96915|Y625_ [...]
Rv2306B protein networkhttps://string-db.org/network/83332.Rv2306BRv2306B, len: 144 aa. Possible conserved membrane protein, similar to C-terminal part of several hypothetical membrane proteins from Mycobacterium tuberculosis and Streptomyces coelicolor e.g. P9 [...]
Rv2307A protein networkhttps://string-db.org/network/83332.Rv2307ARv2307A, len: 63 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv2307B protein networkhttps://string-db.org/network/83332.Rv2307BRv2307B, len: 143 aa. Hypothetical unknown Gly- rich protein. Equivalent to AAK46653 from Mycobacterium tuberculosis strain CDC1551 (133 aa) but longer 10 aa. This region is a possible MT-complex [...]
Rv2307D protein networkhttps://string-db.org/network/83332.Rv2307DRv2307D, len: 60 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv2307c protein networkhttps://string-db.org/network/83332.Rv2307cRv2307c, (MTCY339.02), len: 281 aa. Conserved hypothetical protein, similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 hypothetical protein from Escherichia coli (2 [...]
Rv2308 protein networkhttps://string-db.org/network/83332.Rv2308Rv2308, (MTCY339.01c), len: 238 aa. Conserved hypothetical protein, sharing similarity with O53464|Rv2018|MTV018.05 from Mycobacterium tuberculosis (239 aa), FASTA scores: opt: 142, E(): 0.034, ( [...]
Rv2309A protein networkhttps://string-db.org/network/83332.Rv2309ARv2309A, len: 95 aa. Hypothetical unknown protein. Equivalent to AAK46663 from Mycobacterium tuberculosis strain CDC1551 (95 aa) but longer 13 aa. This region is a possible MT-complex-specific ge [...]
Rv2309c protein networkhttps://string-db.org/network/83332.Rv2309cRv2309c, (MTCY3G12.25), len: 151 aa. Possible integrase (fragment), similar to others e.g. Q48908 integrase (fragment) from Mycobacterium paratuberculos (191 aa), FASTA scores: opt: 279, E(): 3.2 [...]
Rv2310 protein networkhttps://string-db.org/network/83332.Rv2310Possible excisionase; Rv2310, (MT2372, MTCY3G12.24c), len: 114 aa. Possible excisionase, showing some similarity to others e.g. Q9LCU5 putative excisionase from Arthrobacter sp. TM1 (174 aa) FAST [...]
Rv2311 protein networkhttps://string-db.org/network/83332.Rv2311Rv2311, (MTCY3G12.23c), len: 174 aa. Conserved hypothetical protein, with similarity (in part) to transfer proteins homologous TRAA e.g. Q9EUN8|TRAA transfer protein homolog TRAA from Corynebacte [...]
Rv2312 protein networkhttps://string-db.org/network/83332.Rv2312Hypothetical protein; Rv2312, (MTCY3G12.22c), len: 89 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv2313c protein networkhttps://string-db.org/network/83332.Rv2313cHypothetical protein; Rv2313c, (MTCY3G12.21), len: 284 aa. Hypothetical unknown protein; To E.coli YnjA.
Rv2314c protein networkhttps://string-db.org/network/83332.Rv2314cConserved protein; Rv2314c, (MTCY3G12.20), len: 457 aa. Conserved protein, highly similar to Q9RJ51|SCI8.02 hypothetical protein from Streptomyces coelicolor (464 aa) FASTA scores: opt: 1485, E() [...]
Rv2315c protein networkhttps://string-db.org/network/83332.Rv2315cConserved protein; Rv2315c, (MTCY3G12.19), len: 505 aa. Conserved protein, highly similar to Q9S273|SCI28.10 hypothetical 47.1 KDA protein from Streptomyces coelicolor (435 aa),FASTA scores: opt: [...]
uspA protein networkhttps://string-db.org/network/83332.Rv2316Rv2316, (MTCY3G12.18c), len: 290 aa. Probable uspA,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN8|USPA|ML1768 sugar transport integral memb [...]
uspB protein networkhttps://string-db.org/network/83332.Rv2317Rv2317, (MTC3G12.17c), len: 274 aa. Probable uspB,sugar-transport integral membrane protein ABC transporter (see citation below), most similar to Q9CBN7|USPE|ML1769 sugar transport integral membr [...]
uspC protein networkhttps://string-db.org/network/83332.Rv2318Rv2318, (MTCY3G12.16c), len: 440 aa. Probable uspC,sugar-binding lipoprotein component of sugar transport system (see citation below), most similar to Q9CBN6|USPC|ML1770 sugar transport periplasm [...]
Rv2319c protein networkhttps://string-db.org/network/83332.Rv2319cRv2319c, (MTCY3G12.15), len: 292 aa. Universal stress protein family protein.
rocE protein networkhttps://string-db.org/network/83332.Rv2320cRv2320c, (MTCY3G12.14), len: 476 aa. Probable rocE,cationic amino acid (especially arginine and ornithine) transporter (permease), highly similar to other amino acid transporters e.g. Q9L100|SCL6 [...]
rocD2 protein networkhttps://string-db.org/network/83332.Rv2321cRv2321c, (MTCY3G12.13), len: 181 aa. Probable rocD2,ornithine aminotransferase, highly similar to C-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelic [...]
rocD1 protein networkhttps://string-db.org/network/83332.Rv2322cRv2322c, (MTCY3G12.12), len: 221 aa. Probable rocD1,ornithine aminotransferase, highly similar to N-terminal region of other ornithine aminotransferases, e.g. Q9FC90|ROCD from Streptomyces coelic [...]
Rv2323c protein networkhttps://string-db.org/network/83332.Rv2323cConserved protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA); Belongs to the DDAH family.
Rv2324 protein networkhttps://string-db.org/network/83332.Rv2324Rv2324, (MTCY3G12.10), len: 148 aa. Probable transcriptional regulatory protein, asnC-family, similar to other putative AsnC-family regulatory proteins e.g. Q9L101|SCL6.15C from Streptomyces coel [...]
Rv2325c protein networkhttps://string-db.org/network/83332.Rv2325cRv2325c, (MTCY3G12.09), len: 282 aa. Conserved hypothetical protein, equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1405,E(): 1 [...]
Rv2326c protein networkhttps://string-db.org/network/83332.Rv2326cRv2326c, (MTC3G12.08), len: 697 aa. Possible transmembrane ATP-binding protein ABC transporter (see citation below). Equivalent to Q9CCF9|ML0848 ABC transporter from Mycobacterium leprae (724 aa) [...]
Rv2327 protein networkhttps://string-db.org/network/83332.Rv2327Conserved protein; Rv2327, (MTCY3G12.07c), len: 163 aa. Conserved protein, similar to Z80775|MTCY21D4.05c|Rv0042c from Mycobacterium tuberculosis (208 aa), FASTA scores: opt: 242, E(): 5e-08, (43 [...]
PE23 protein networkhttps://string-db.org/network/83332.Rv2328Rv2328, (MTCY3G12.06), len: 382 aa. PE23, Member of the Mycobacterium tuberculosis PE family (see citation below), similar to others e.g. Q9L8K5|MAG24-1 PE-PGRS homolog from Mycobacterium marinum [...]
narK1 protein networkhttps://string-db.org/network/83332.Rv2329cRv2329c, (MTCY3G12.05), len: 515 aa. Probable narK1,nitrite extrusion protein, possibly member of major facilitator superfamily (MFS). Equivalent to O32974|MLCB22.41c|nark|ML0844 putative nitrite [...]
lppP protein networkhttps://string-db.org/network/83332.Rv2330cRv2330c, (MTCY3G12.04), len: 175 aa. Probable lppP,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
Rv2331 protein networkhttps://string-db.org/network/83332.Rv2331Hypothetical protein; Rv2331, (MT2393, MTCY3G12.03c), len: 128 aa. Hypothetical unknown protein; shortened version of MTCY3G12.03c to eliminate overlap with MTCY3G12.04.
Rv2331A protein networkhttps://string-db.org/network/83332.Rv2331ARv2331A, len: 112 aa. Hypothetical unknown protein.
mez protein networkhttps://string-db.org/network/83332.Rv2332Putative malate oxidoreductase [NAD]; Rv2332, (MTCY3G12.02c, MTCY98.01, MT2394), len: 548 aa. Probable mez, malate oxidoreductase [NAD] dependent (malic enzyme), highly similar to others e.g. O34 [...]
stp protein networkhttps://string-db.org/network/83332.Rv2333cIntegral membrane drug efflux protein Stp; Contributes to spectinomycin and tetracycline resistance. Belongs to the major facilitator superfamily. EmrB family.
cysK1 protein networkhttps://string-db.org/network/83332.Rv2334O-acetylserine sulfhydrylase; Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide. Belongs to the cysteine synthase/cy [...]
cysE protein networkhttps://string-db.org/network/83332.Rv2335Probable serine acetyltransferase CysE (sat); Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS); Belongs to the transferase hexapeptide repeat family.
Rv2336 protein networkhttps://string-db.org/network/83332.Rv2336Hypothetical protein; Rv2336, (MTCY98.05), len: 322 aa. Hypothetical unknown protein (see Rindi et al., 2001). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007) [...]
Rv2337c protein networkhttps://string-db.org/network/83332.Rv2337cHypothetical protein; Rv2337c, (MTCY98.06c), len: 372 aa. Hypothetical unknown protein, sharing some similarity with Q9RI33|SCJ12.27c hypothetical 37.2 KDA protein from Streptomyces coelicolor (3 [...]
moeW protein networkhttps://string-db.org/network/83332.Rv2338cRv2338c, (MTCY98.07c), len: 318 aa. Possible moeW,molybdoptenum biosynthesis protein, showing some similarity to several molybdopterin biosynthesis proteins e.g. O27613|MTH1571 molybdopterin bios [...]
mmpL9 protein networkhttps://string-db.org/network/83332.Rv2339Rv2339, (MTCY98.08), len: 962 aa. Probable mmpL9,conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4 [...]
PE_PGRS39 protein networkhttps://string-db.org/network/83332.Rv2340cPE-PGRS family protein PE_PGRS39; Rv2340c, (MTCY98.09c), len: 413 aa. PE_PGRS39,Member of the Mycobacterium tuberculosis PE_family, PGRS subfamily of gly-rich proteins (see citations below),simil [...]
lppQ protein networkhttps://string-db.org/network/83332.Rv2341Rv2341, (MTCY98.10), len: 139 aa. Probable lppQ,conserved lipoprotein, showing some similarity with Rv1228|O33224|LPQX|MTCI61.11 from Mycobacterium tuberculosis (185 aa), FASTA scores: opt: 155; [...]
Rv2342 protein networkhttps://string-db.org/network/83332.Rv2342Rv2342, (MTCY98.11), len: 85 aa. Conserved hypothetical protein, highly similar to Q9CCG1|ML0834 hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 392, E(): 2.9e-20, (78. [...]
dnaG protein networkhttps://string-db.org/network/83332.Rv2343cProbable DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family.
dgt protein networkhttps://string-db.org/network/83332.Rv2344cRv2344c, (MT2409, MTCY98.13c), len: 431 aa. Probable dgt, deoxyguanosine triphosphate triphosphohydrolase,equivalent to Q9CCG3|DGT|ML0831 putative deoxyguanosine triphosphate triphosphohydrolase [...]
Rv2345 protein networkhttps://string-db.org/network/83332.Rv2345Possible conserved transmembrane protein; May play a role in septum formation. Belongs to the UPF0603 family.
esxO protein networkhttps://string-db.org/network/83332.Rv2346cPutative ESAT-6 like protein EsxO (ESAT-6 like protein 6); Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacil [...]
esxP protein networkhttps://string-db.org/network/83332.Rv2347cRv2347c, (MT2412, MTCY98.16c), len: 98 aa. EsxP,ESAT-6 like protein (see citation below). Member of M. tuberculosis hypothetical QILSS protein family with Rv1197,Rv1792, Rv1038c and Rv3620c. Belo [...]
Rv2348c protein networkhttps://string-db.org/network/83332.Rv2348cHypothetical protein; Rv2348c, (MTCY98.17c), len: 108 aa. Hypothetical unknown protein.
plcC protein networkhttps://string-db.org/network/83332.Rv2349cRv2349c, (MT2414, MTCY98.18c), len: 508 aa. Probable plcC, phospolipase C 3 (see citations below), similar to other precursors of several phospolipases C e.g. P15713|PHLN_PSEAE|PA3319 non-hemolyt [...]
plcB protein networkhttps://string-db.org/network/83332.Rv2350cMembrane-associated phospholipase C 2 PlcB; Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis at the level of [...]
plcA protein networkhttps://string-db.org/network/83332.Rv2351cMembrane-associated phospholipase C 1 PlcA (MTP40 antigen); Hydrolyzes sphingomyelin in addition to phosphatidylcholine. Probable virulence factor implicated in the pathogenesis of M.tuberculosis [...]
PPE38 protein networkhttps://string-db.org/network/83332.Rv2352cRv2352c, (MTCY98.21c), len: 391 aa. PPE38, Member of Mycobacterium tuberculosis PPE_family, highly similar to many e.g. Q10778|MTCY48.17|Y04H_MYCTU (734 aa), FASTA scores: opt: 713, E(): 2.8e-27, [...]
PPE39 protein networkhttps://string-db.org/network/83332.Rv2353cRv2353c, (MTCY98.22c), len: 354 aa. PPE39, Member of Mycobacterium tuberculosis PPE family, highly similar to many e.g. near ORF P95249|Rv2356c|MTCY98.25 from Mycobacterium tuberculosis (615 aa), [...]
Rv2354 protein networkhttps://string-db.org/network/83332.Rv2354Rv2354, (MTCY98.23), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a [...]
Rv2355 protein networkhttps://string-db.org/network/83332.Rv2355Probable transposase; Rv2355, (MTCY98.24), len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be mad [...]
PPE40 protein networkhttps://string-db.org/network/83332.Rv2356cRv2356c, (MTCY98.25), len: 615 aa. PPE40, Member of Mycobacterium tuberculosis PPE_family, highly similar to others e.g. Q10778|MTCY48.17|YF48_MYCTU hypothetical PPE-family protein (678 aa), FAST [...]
glyS protein networkhttps://string-db.org/network/83332.Rv2357cProbable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS); Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
smtB protein networkhttps://string-db.org/network/83332.Rv2358Probable transcriptional regulatory protein SmtB (probably ArsR-family); Transcriptional regulator involved in zinc homeostasis. Represses the expression of the smtB-zur operon in the absence of [...]
zur protein networkhttps://string-db.org/network/83332.Rv2359Probable zinc uptake regulation protein Zur; Global transcriptional regulator involved in zinc homeostasis. Represses the transcription of at least 32 genes, including genes involved in zinc home [...]
Rv2360c protein networkhttps://string-db.org/network/83332.Rv2360cUnknown protein; Rv2360c, (MTCY27.20), len: 142 aa. Unknown protein.
uppS protein networkhttps://string-db.org/network/83332.Rv2361cLong (C50) chain Z-isoprenyl diphosphate synthase (Z-decaprenyl diphosphate synthase); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E) [...]
recO protein networkhttps://string-db.org/network/83332.Rv2362cPossible DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
amiA2 protein networkhttps://string-db.org/network/83332.Rv2363Rv2363, (MTCY27.17c), len: 484 aa. Probable amiA2,amidase, highly similar or similar to others e.g. O28325|YJ54_ARCFU|AF1954 putative amidase from Archaeoglobus fulgidus (453 aa), FASTA scores: o [...]
era protein networkhttps://string-db.org/network/83332.Rv2364cProbable GTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and pos [...]
Rv2365c protein networkhttps://string-db.org/network/83332.Rv2365cRv2365c, (MTCY27.15), len: 113 aa. Conserved hypothetical protein, highly similar to Q49767|ML0630|B1937_F3_101|CAC30138 Hypothetical protein from Mycobacterium leprae (108 aa), FASTA scores: opt [...]
Rv2366c protein networkhttps://string-db.org/network/83332.Rv2366cRv2366c, (MTCY27.14), len: 435 aa. Probable conserved transmembrane protein, highly similar to Q9L2L3|SCC117.07 putative membrane protein from Streptomyces coelicolor (358 aa), FASTA scores: opt: [...]
ybeY protein networkhttps://string-db.org/network/83332.Rv2367cConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
phoH1 protein networkhttps://string-db.org/network/83332.Rv2368cRv2368c, (MTCY27.12), len: 352 aa. Probable phoH1,phoH-like protein (phosphate starvation-induced protein),probably ATP-binding protein, equivalent to Q49751|PHOL_MYCLE| ML0627|B1937_F1_20 PHOH-l [...]
Rv2369c protein networkhttps://string-db.org/network/83332.Rv2369cHypothetical protein; Rv2369c, (MTCY27.11), len: 100 aa. Hypothetical unknown protein.
Rv2370c protein networkhttps://string-db.org/network/83332.Rv2370cRv2370c, (MTCY27.10), len: 437 aa. Conserved hypothetical protein, member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 conserved hypothetical protein from Myc [...]
PE_PGRS40 protein networkhttps://string-db.org/network/83332.Rv2371Rv2371, (MTCY27.09c), len: 61 aa. PE_PGRS40, Short protein, member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to N-termi [...]
rsmE protein networkhttps://string-db.org/network/83332.Rv2372cConserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) [...]
dnaJ2 protein networkhttps://string-db.org/network/83332.Rv2373cProbable chaperone protein DnaJ2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, a [...]
hrcA protein networkhttps://string-db.org/network/83332.Rv2374cProbable heat shock protein transcriptional repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons; Be [...]
Rv2375 protein networkhttps://string-db.org/network/83332.Rv2375Rv2375, (MTCY27.05c), len: 105 aa. Conserved hypothetical protein, highly similar to only CAC32314|2SCD60.09c conserved hypothetical protein from Streptomyces coelicolor (98 aa), FASTA scores: op [...]
cfp2 protein networkhttps://string-db.org/network/83332.Rv2376cLow molecular weight antigen CFP2 (low molecular weight protein antigen 2) (CFP-2); May play a role in the development of protective immune responses; Belongs to the MTB12 family.
mbtH protein networkhttps://string-db.org/network/83332.Rv2377cPutative conserved protein MbtH; Could be involved in mycobactin synthesis.
mbtG protein networkhttps://string-db.org/network/83332.Rv2378cLysine-N-oxygenase MbtG (L-lysine 6-monooxygenase) (lysine N6-hydroxylase); Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, [...]
mbtF protein networkhttps://string-db.org/network/83332.Rv2379cRv2379c, (MTCY27.01), len: 1461 aa. MbtF, peptide synthetase (see citations below), similar in part to several synthases e.g. O52820|PCZA363.4 protein from Amycolatopsis orientalis (4077 aa), FAS [...]
mbtE protein networkhttps://string-db.org/network/83332.Rv2380cRv2380c, (MTCY22H8.05), len: 1682 aa. MbtE, peptide synthetase (see citations below), similar in part to several synthases e.g. O07944|SNBDE pristinamycin I synthase 3 and 4 from Streptomyces pri [...]
mbtD protein networkhttps://string-db.org/network/83332.Rv2381cPolyketide synthetase MbtD (polyketide synthase); Rv2381c, (MTCY22H8.04), len: 1004 aa. MbtD,polyketide synthase (see citations below), similar in part to several synthases e.g. Q03132|ERY2_SACER [...]
mbtC protein networkhttps://string-db.org/network/83332.Rv2382cPolyketide synthetase MbtC (polyketide synthase); Rv2382c, (MTCY22H8.03), len: 444 aa. MbtC,polyketide synthase (see citations below), similar in part to several synthases e.g. Q9F7T9 avermectin [...]
mbtB protein networkhttps://string-db.org/network/83332.Rv2383cPhenyloxazoline synthase MbtB (phenyloxazoline synthetase); Involved in the initial steps of the mycobactin biosynthetic pathway. Putatively couples activated salicylic acid with serine or threon [...]
mbtA protein networkhttps://string-db.org/network/83332.Rv2384Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase; Involved in the initial steps of the mycobactin biosynthetic pathway. Catalyzes the salicylation of the [...]
mbtJ protein networkhttps://string-db.org/network/83332.Rv2385Rv2385, (MTCY253.36c), len: 306 aa. Putative mbtJ,acetyl hydrolase (see citations below), showing some similarity with various hydrolases including acetyl hydrolases e.g. Q9ZBM4|MLCB1450.08|ML031 [...]
mbtI protein networkhttps://string-db.org/network/83332.Rv2386cIsochorismate synthase MbtI; Involved in the incorporation of salicylate into the virulence-conferring salicylate-based siderophore mycobactin. Catalyzes the initial conversion of chorismate to y [...]
Rv2387 protein networkhttps://string-db.org/network/83332.Rv2387Conserved protein; Rv2387, (MTCY253.34c), len: 417 aa. Conserved protein, showing some similarities with others e.g. Q9K663|BH3869 hypothetical protein from Bacillus halodurans (337 aa), FASTA sc [...]
hemN protein networkhttps://string-db.org/network/83332.Rv2388cHeme chaperone HemW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] clu [...]
rpfD protein networkhttps://string-db.org/network/83332.Rv2389cProbable resuscitation-promoting factor RpfD; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little t [...]
Rv2390c protein networkhttps://string-db.org/network/83332.Rv2390cRv2390c, (MTCY253.31), len: 185 aa. Conserved hypothetical protein, similar to other Mycobacterium tuberculosis proteins Q11032|YD62_MYCTU|MTCY02B10.26c|Rv1362c hypothetical 23.5 kDa protein (220 [...]
sirA protein networkhttps://string-db.org/network/83332.Rv2391Ferredoxin-dependent sulfite reductase SirA; Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. Belongs to the nitrite and s [...]
cysH protein networkhttps://string-db.org/network/83332.Rv2392Probable phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
che1 protein networkhttps://string-db.org/network/83332.Rv2393Ferrochelatase Che1; Rv2393, (MTCY253.28c), len: 281 aa. Che1,ferrochelatase (See Pinto et al., 2007). Conserved protein,with some similarity to Q9L2E8|SC7A8.10c putative secreted protein from St [...]
ggtB protein networkhttps://string-db.org/network/83332.Rv2394Rv2394, (MTCY253.27c), len: 643 aa. Probable ggtB,gamma-glutamyltranspeptidase precursor, similar to many e.g. Q9KVF2|VC0194 from Vibrio cholerae (588 aa), FASTA scores: opt: 943, E(): 7.5e-47, ( [...]
Rv2395 protein networkhttps://string-db.org/network/83332.Rv2395Rv2395, (MTCY253.26c), len: 667 aa. Probable conserved integral membrane protein, similar to AAK24613|CC2646 oligopeptide transporter/opt family protein from Caulobacter crescentus (666 aa), FAST [...]
aprA protein networkhttps://string-db.org/network/83332.Rv2395ARv2395A, len: 71 aa. AprA, acid and phagosome regulated protein A, restricted to M. tuberculosis complex. Note completely overlapped by sRNA mcr7.
aprB protein networkhttps://string-db.org/network/83332.Rv2395BRv2395B, len: 54 aa. AprB, acid and phagosome regulated protein B, restricted to M. tuberculosis complex.
PE_PGRS41 protein networkhttps://string-db.org/network/83332.Rv2396PE-PGRS family protein PE_PGRS41; Rv2396, (MTCY253.25c), len: 361 aa. PE_PGRS41,member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below). Also [...]
cysA1 protein networkhttps://string-db.org/network/83332.Rv2397cSulfate-transport ATP-binding protein ABC transporter CysA1; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport s [...]
cysW protein networkhttps://string-db.org/network/83332.Rv2398cRv2398c, (MTCY253.23), len: 272 aa. Probable cysW,sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 sulfate ABC transpor [...]
cysT protein networkhttps://string-db.org/network/83332.Rv2399cProbable sulfate-transport integral membrane protein ABC transporter CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
subI protein networkhttps://string-db.org/network/83332.Rv2400cRv2400c, (MTCY253.21), len: 356 aa. Probable subI,sulfate-binding lipoprotein component of sulfate transport system (see citations below), equivalent to Q9CCN3|SUBI|ML0615 (alias Q49748|B1937_F1_ [...]
Rv2401 protein networkhttps://string-db.org/network/83332.Rv2401Hypothetical protein; Rv2401, (MTCY253.19c), len: 109 aa. Hypothetical unknown protein. Equivalent to AAK46768 from Mycobacterium tuberculosis strain CDC1551 (134 aa) but shorter 25 aa. N-terminu [...]
Rv2401A protein networkhttps://string-db.org/network/83332.Rv2401ARv2401A, len: 67 aa. Possible conserved membrane protein, highly similar, but with 29 aa shorter, to ML0614|AL583919_34|Q49760 from Mycobacterium leprae (95 aa), FASTA scores: opt: 297, E(): 3.6e [...]
Rv2402 protein networkhttps://string-db.org/network/83332.Rv2402Conserved protein; Catalyzes the hydrolysis of alpha,alpha-trehalose into two molecules of D-glucose.
lppR protein networkhttps://string-db.org/network/83332.Rv2403cRv2403c, (MTCY253.17), len: 251 aa. Probable lppR,conserved lipoprotein, with weak similarity with mycobacterial serine/threonine protein kinases e.g. AAK45563|MT1304 from Mycobacterium tuberculo [...]
lepA protein networkhttps://string-db.org/network/83332.Rv2404cProbable GTP-binding protein LepA (GTP-binding elongation factor); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the trans [...]
Rv2405 protein networkhttps://string-db.org/network/83332.Rv2405Conserved protein; Rv2405, (MTCY253.15c), len: 189 aa. Conserved protein, identical (but N-terminus longer 40 residues) to AAK46773|MT2477 hypothetical protein from Mycobacterium tuberculosis str [...]
Rv2406c protein networkhttps://string-db.org/network/83332.Rv2406cConserved protein; Rv2406c, (MTCY253.14), len: 142 aa. Conserved protein. C-terminal region is identical with many CBS domain protein e.g. AAK46774|MT2478 CBS domain protein from Mycobacterium tu [...]
rnz protein networkhttps://string-db.org/network/83332.Rv2407Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precurso [...]
PE24 protein networkhttps://string-db.org/network/83332.Rv2408Possible PE family-related protein PE24; Rv2408, (MTCY253.12c), len: 239 aa. Possibly PE24, a member of PE family (see citation below), similar to AAK46440|MT2159 from Mycobacterium tuberculosis [...]
Rv2409c protein networkhttps://string-db.org/network/83332.Rv2409cConserved protein; Rv2409c, (MTCY253.11), len: 279 aa. Conserved protein, equivalent to Q49757|YP69_MYCLE|G466976|B1937_F2_39 hypothetical protein from Mycobacterium leprae (279 aa), FASTA scores [...]
Rv2410c protein networkhttps://string-db.org/network/83332.Rv2410cConserved protein; Rv2410c, (MTCY253.10), len: 325 aa. Conserved protein, equivalent to Q49770|CAC30114|ML0606 conserved hypothetical protein from Mycobacterium leprae (325 aa),FASTA scores: opt: [...]
Rv2411c protein networkhttps://string-db.org/network/83332.Rv2411cRv2411c, (MTCY253.09c), len: 551 aa. Hypothetical protein, highly similar to Q49755|YO11_MYCLE|ML0605|MLCL536.05c|U1937B|B1937_F1_4 hypothetical 61.8 KDA protein from Mycobacterium leprae (561 aa [...]
rpsT protein networkhttps://string-db.org/network/83332.Rv241230S ribosomal protein S20 RpsT; Binds directly to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS20 family.
Rv2413c protein networkhttps://string-db.org/network/83332.Rv2413cRv2413c, (MTCY253.07), len: 316 aa. Conserved hypothetical protein, highly similar to O33133|MLCL536.07c|ML0603|Q49756|G466975|B1937_F2_36 hypothetical 39.1 KDA protein from Mycobacterium leprae [...]
Rv2414c protein networkhttps://string-db.org/network/83332.Rv2414cRv2414c, (MTCY253.06), len: 514 aa. Conserved hypothetical protein, showing some similarity with come operon proteins 3 (COMEC or COME3) e.g. Q9RTB1|DR1854 putative competence protein COMEC/REC2 [...]
Rv2415c protein networkhttps://string-db.org/network/83332.Rv2415cRv2415c, (MTCY253.05), len: 297 aa. Hypothetical protein, with some similarity in C-terminal part to comE operon proteins 1 e.g. Q9EU10|come|COME4|COME1|COME2|COME3 come protein (a competence pro [...]
eis protein networkhttps://string-db.org/network/83332.Rv2416cEnhanced intracellular survival protein Eis,GCN5-related N-acetyltransferase; Effector that is released into the host cell and affects host immune responses; it negatively modulates inflammation, [...]
Rv2417c protein networkhttps://string-db.org/network/83332.Rv2417cConserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
octT protein networkhttps://string-db.org/network/83332.Rv2418cUnknown protein; Sugar octanoyltransferase likely involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharide (MGLP). Catalyzes the transfer of an octanoyl group from octanoyl- [...]
gpgP protein networkhttps://string-db.org/network/83332.Rv2419cGlucosyl-3-phosphoglycerate phosphatase GpgP; Involved in the biosynthesis of mycobacterial methylglucose lipopolysaccharides (MGLPs). Catalyzes the dephosphorylation of glucosyl-3-phosphoglycera [...]
rsfS protein networkhttps://string-db.org/network/83332.Rv2420cConserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 3 [...]
nadD protein networkhttps://string-db.org/network/83332.Rv2421cProbable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Rv2422 protein networkhttps://string-db.org/network/83332.Rv2422Hypothetical protein; Rv2422, (MTCY428.25c), len: 90 aa. Hypothetical unknown protein.
Rv2423 protein networkhttps://string-db.org/network/83332.Rv2423Hypothetical protein; Rv2423, (MTCY428.24c), len: 348 aa. Hypothetical unknown protein.
Rv2424c protein networkhttps://string-db.org/network/83332.Rv2424cProbable transposase; Rv2424c, (MTCY428.23), len: 333 aa. Probable transposase for IS1558, similar to is element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), [...]
Rv2425c protein networkhttps://string-db.org/network/83332.Rv2425cRv2425c, (MTCY428.22), len: 480 aa. Hypothetical protein; C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 hypothetical 24.3 KDA protein from Rhodococcus erythrop [...]
Rv2426c protein networkhttps://string-db.org/network/83332.Rv2426cRv2426c, (MTCY428.21), len: 291 aa. Conserved hypothetical protein, highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa),FASTA scores: opt: 853, E(): 3.7e-43, (48.7 [...]
oxyR protein networkhttps://string-db.org/network/83332.Rv2427ARv2427A, Pseudogene oxyR', inactivated by multiple mutations; identical to sequence in u16243 (see Deretic et al., 1995).
proA protein networkhttps://string-db.org/network/83332.Rv2427cGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclizat [...]
ahpC protein networkhttps://string-db.org/network/83332.Rv2428Alkyl hydroperoxide reductase C protein AhpC (alkyl hydroperoxidase C); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohol [...]
ahpD protein networkhttps://string-db.org/network/83332.Rv2429Alkyl hydroperoxide reductase D protein AhpD (alkyl hydroperoxidase D); Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residu [...]
PPE41 protein networkhttps://string-db.org/network/83332.Rv2430cPPE family protein PPE41; The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. The dimer induces necrosis, but not apoptosis, in mouse macrophage cells. It also induce [...]
PE25 protein networkhttps://string-db.org/network/83332.Rv2431cPE family protein PE25; The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response. The dimer induces necrosis, but not apoptosis, in [...]
Rv2432c protein networkhttps://string-db.org/network/83332.Rv2432cHypothetical protein; Rv2432c, (MTCY428.14), len: 136 aa. Hypothetical unknown protein.
Rv2433c protein networkhttps://string-db.org/network/83332.Rv2433cHypothetical protein; Rv2433c, (MTCY428.13), len: 96 aa. Hypothetical unknown protein.
Rv2434c protein networkhttps://string-db.org/network/83332.Rv2434cRv2434c, (MTCY428.12), len: 481 aa. Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 probable integral membrane protein from Rhizobium loti (410 aa), FASTA score [...]
Rv2435c protein networkhttps://string-db.org/network/83332.Rv2435cProbable cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-); Rv2435c, (MTCY428.11), len: 730 aa. Probable cyclase (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or 4.6.1.2 respectively); C-term [...]
rbsK protein networkhttps://string-db.org/network/83332.Rv2436Ribokinase RbsK; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, [...]
Rv2437 protein networkhttps://string-db.org/network/83332.Rv2437Rv2437, (MTCY428.09c), len: 139 aa. Conserved transmembrane protein, with some similarity to conserved hypothetical proteins e.g. O06539|RV1139C|MTCI65.06c from Mycobacterium tuberculosis (166 aa [...]
Rv2438A protein networkhttps://string-db.org/network/83332.Rv2438ARv2438A, len: 92 aa. Conserved hypothetical protein,showing few similarity with various enzymes e.g. part of O83441|VAA1_TREPA|ATPA1|TP0426 V-type ATP synthase alpha chain 1 from Treponema pallid [...]
nadE protein networkhttps://string-db.org/network/83332.Rv2438cGlutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. In v [...]
proB protein networkhttps://string-db.org/network/83332.Rv2439cProbable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
obg protein networkhttps://string-db.org/network/83332.Rv2440cProbable GTP1/Obg-family GTP-binding protein Obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP h [...]
rpmA protein networkhttps://string-db.org/network/83332.Rv2441cRv2441c, (MTCY428.05), len: 86 aa. rpmA, 50S ribosomal proteins L27, equivalent to Q9CBZ3|RL27_MYCLE from Mycobacterium leprae (88 aa), FASTA scores: opt: 504,E(): 7.6e-28, (93.2% identity in 81 [...]
rplU protein networkhttps://string-db.org/network/83332.Rv2442c50S ribosomal protein L21 RplU; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
dctA protein networkhttps://string-db.org/network/83332.Rv2443Rv2443, (MTCY428.03c), len: 491 aa. Probable dctA,C4-dicarboxylate-transport transmembrane protein, similar to other C4-dicarboxylate transport proteins e.g. AAK46817|MT2519 from Mycobacterium tu [...]
rne protein networkhttps://string-db.org/network/83332.Rv2444cRv2444c, (MTCY428.02), len: 953 aa. Possible rne,ribonuclease E, highly similar to others e.g. Q9CBZ1|ML1468 possible ribonuclease from Mycobacterium leprae (924 aa),FASTA scores: opt: 3713, E(): [...]
ndkA protein networkhttps://string-db.org/network/83332.Rv2445cProbable nucleoside diphosphate kinase NdkA (NDK) (NDP kinase) (nucleoside-2-P kinase); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transfer [...]
Rv2446c protein networkhttps://string-db.org/network/83332.Rv2446cRv2446c, (MTV008.02c), len: 123 aa. Probable conserved integral membrane protein, highly similar to Q9CBY9|ML1470 conserved membrane protein from Mycobacterium leprae (123 aa), FASTA scores: opt: [...]
folC protein networkhttps://string-db.org/network/83332.Rv2447cProbable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS); Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to [...]
valS protein networkhttps://string-db.org/network/83332.Rv2448cValine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, [...]
Rv2449c protein networkhttps://string-db.org/network/83332.Rv2449cConserved protein; Rv2449c, (MTV008.05c), len: 419 aa. Conserved protein, highly similar to hypothetical proteins e.g. P95139|Rv2953|MTCY349.37c from M. tuberculosis (418 aa),FASTA scores: opt: 1 [...]
rpfE protein networkhttps://string-db.org/network/83332.Rv2450cProbable resuscitation-promoting factor RpfE; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little t [...]
Rv2451 protein networkhttps://string-db.org/network/83332.Rv2451Rv2451, (MTV008.07), len: 132 aa. Hypothetical unknown pro-, ser-rich protein.
Rv2452c protein networkhttps://string-db.org/network/83332.Rv2452cHypothetical protein; Rv2452c, (MTV008.08c), len: 48 aa. Hypothetical unknown protein (see citation below).
mobA protein networkhttps://string-db.org/network/83332.Rv2453cProbable molybdopterin-guanine dinucleotide biosynthesis protein A MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopter [...]
korB protein networkhttps://string-db.org/network/83332.Rv2454cProbable oxidoreductase (beta subunit); Component of KG oxidoreductase (KOR) that catalyzes the CoA- dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl-C [...]
korA protein networkhttps://string-db.org/network/83332.Rv2455cProbable oxidoreductase (alpha subunit); Component of KG oxidoreductase (KOR) that catalyzes the CoA- dependent oxidative decarboxylation of 2-oxoglutarate (alpha- ketoglutarate, KG) to succinyl- [...]
Rv2456c protein networkhttps://string-db.org/network/83332.Rv2456cRv2456c, (MTV008.12c), len: 418 aa. Probable conserved integral membrane transport protein, involved in a efflux system, weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 putative sugar efflux [...]
clpX protein networkhttps://string-db.org/network/83332.Rv2457cProbable ATP-dependent CLP protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functi [...]
mmuM protein networkhttps://string-db.org/network/83332.Rv2458Rv2458, (MTV008.14), len: 302 aa. Probable mmuM,homocysteine S-methyltransferase, equivalent to Q9CBY5|ML1478 possible transferase from Mycobacterium leprae (293 aa), FASTA scores: opt: 1507, E() [...]
jefA protein networkhttps://string-db.org/network/83332.Rv2459Probable conserved integral membrane transport protein; Involved in resistance to ethambutol and isoniazid. Belongs to the major facilitator superfamily.
clpP2 protein networkhttps://string-db.org/network/83332.Rv2460cProbable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like acti [...]
clpP1 protein networkhttps://string-db.org/network/83332.Rv2461cProbable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activi [...]
tig protein networkhttps://string-db.org/network/83332.Rv2462cProbable trigger factor (TF) protein Tig; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis- [...]
lipP protein networkhttps://string-db.org/network/83332.Rv2463Rv2463, (MTV008.19), len: 394 aa. Probable lipP,esterase, lipase similar to others eg O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 964, E(): 1.9e-53, (44.35% [...]
nei1 protein networkhttps://string-db.org/network/83332.Rv2464cPossible DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. DNA glycosylase that recognizes and removes damaged pyrimidines. Excises Tg:A (thymi [...]
rpiB protein networkhttps://string-db.org/network/83332.Rv2465cRibose-5-phosphate isomerase; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It has not isomerase activity towards D-allose 6-phosphate.
Rv2466c protein networkhttps://string-db.org/network/83332.Rv2466cConserved protein; In vitro, the reduced form of Rv2466c catalyzes the reduction and activation of TP053, which is a thienopyrimidine derivative drug that can kill both replicating and non-replic [...]
pepN protein networkhttps://string-db.org/network/83332.Rv2467Probable aminopeptidase N PepN (Lysyl aminopeptidase) (LYS-AP) (alanine aminopeptidase); Rv2467, (MTV008.23), len: 861 aa. Probable pepN,aminopeptidase N, equivalent to Q9CBX9|ML1486 probable ami [...]
Rv2468A protein networkhttps://string-db.org/network/83332.Rv2468ARv2468A, len: 77 aa. Conserved protein.
Rv2468c protein networkhttps://string-db.org/network/83332.Rv2468cConserved protein; Rv2468c, (MTV008.24c), len: 167 aa. Conserved protein, highly similar to Mycobacterium leprae hypothetical proteins Q9CC58|ML1255 (163 aa), FASTA scores: opt: 859, E(): 1.6e-49 [...]
Rv2469c protein networkhttps://string-db.org/network/83332.Rv2469cRv2469c, (MTV008.25c), len: 222 aa. Conserved hypothetical protein, highly similar to other hypothetical proteins e.g. Q9X7B4|MLCB1610.15|ML1254 from Mycobacterium leprae (215 aa), FASTA scores: [...]
glbO protein networkhttps://string-db.org/network/83332.Rv2470Globin (oxygen-binding protein) GlbO; When expressed in E.coli and M.smegmatis, HbO increases oxygen uptake. Membrane vesicles of E.coli carrying HbO show a respiration activity about twice that [...]
aglA protein networkhttps://string-db.org/network/83332.Rv2471Alpha-glucosidase AglA; Rv2471, (MTV008.27), len: 546 aa. Probable aglA,maltase (alpha-glucosidase), highly similar or similar to several e.g. Q60027|AGLA from Thermomonospora curvata (544 aa), F [...]
Rv2472 protein networkhttps://string-db.org/network/83332.Rv2472Rv2472, (MTV008.28), len: 97 aa. Conserved hypothetical protein, showing some similarity to O53451|Rv1103c|MTV017.56c from Mycobacterium tuberculosis strain H37Rv (106 aa), FASTA scores: opt: 135 [...]
Rv2473 protein networkhttps://string-db.org/network/83332.Rv2473Rv2473, (MTV008.29), len: 238 aa. Possible pro-,ala-rich membrane protein, with possible transmembrane domain around aa 81-104.
Rv2474c protein networkhttps://string-db.org/network/83332.Rv2474cRv2474c, (MTV008.30c), len: 217 aa. Hypothetical protein. Shows weak similarity with Q9L246|SC6D10.18c hypothetical 24.9 KDA protein from Streptomyces coelicolor (238 aa), FASTA scores: opt: 111, [...]
Rv2475c protein networkhttps://string-db.org/network/83332.Rv2475cConserved protein; Rv2475c, (MTV008.31c), len: 138 aa. Conserved protein, showing similarity with Q9L245|SC6D10.19c hypothetical 16.2 KDA protein from Streptomyces coelicolor (136 aa), FASTA scor [...]
gdh protein networkhttps://string-db.org/network/83332.Rv2476cProbable NAD-dependent glutamate dehydrogenase Gdh (NAD-Gdh) (NAD-dependent glutamic dehydrogenase); Catalyzes the reversible conversion of L-glutamate to 2- oxoglutarate.
ettA protein networkhttps://string-db.org/network/83332.Rv2477cProbable macrolide-transport ATP-binding protein ABC transporter; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) [...]
Rv2478c protein networkhttps://string-db.org/network/83332.Rv2478cRv2478c, (MTV008.34c), len: 161 aa. Conserved hypothetical protein, with weak similarity with many single-strand binding proteins e.g. Q9X8U3|SCH24.29 putative single-strand binding protein from [...]
Rv2479c protein networkhttps://string-db.org/network/83332.Rv2479cProbable transposase; Rv2479c, (MTV008.35c), len: 328 aa. Probable transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may [...]
Rv2480c protein networkhttps://string-db.org/network/83332.Rv2480cRv2480c, (MTV008.36c), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by [...]
Rv2481c protein networkhttps://string-db.org/network/83332.Rv2481cHypothetical protein; Rv2481c, (MTV008.37c), len: 107 aa. Hypothetical unknown protein.
plsB2 protein networkhttps://string-db.org/network/83332.Rv2482cRv2482c, (MT2555, MTV008.38c), len: 789 aa. Probable plsB2, glycerol-3-phosphate acyltransferase, highly similar to Q9X7B0|PLSB_MYCLE probable glycerol-3-phosphate acyltransferase from Mycobacter [...]
plsC protein networkhttps://string-db.org/network/83332.Rv2483cPlsC domain-containing protein; Rv2483c, (MTV008.39c), len: 580 aa. Possible plsC, a transmembrane phospholipid biosynthesis bifunctional enzyme, including L-3-phosphoserine phosphatase and 1-acy [...]
Rv2484c protein networkhttps://string-db.org/network/83332.Rv2484cPossible triacylglycerol synthase (diacylglycerol acyltransferase); Upon expression in E.coli functions very weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and lon [...]
lipQ protein networkhttps://string-db.org/network/83332.Rv2485cProbable carboxylesterase LipQ; Shows lipase activity. Is highly immunogenic and may play an important role in the virulence and pathogenesis of M.tuberculosis infection, by altering the balance [...]
echA14 protein networkhttps://string-db.org/network/83332.Rv2486Probable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Could possibly oxidize fatty acids using specific components.
PE_PGRS42 protein networkhttps://string-db.org/network/83332.Rv2487cPE-PGRS family protein PE_PGRS42; Rv2487c, (MTV008.43c), len: 694 aa. PE_PGRS42,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins (see citation below),simila [...]
Rv2488c protein networkhttps://string-db.org/network/83332.Rv2488cRv2488c, (MTV008.44c), len: 1137 aa. Probable transcriptional regulatory protein, belonging to luxR family, similar to many in Mycobacterium tuberculosis e.g. AAK44621|MT0399 from strain CDC1551 [...]
Rv2489c protein networkhttps://string-db.org/network/83332.Rv2489cRv2489c, (MTV008.45c), len: 99 aa. Hypothetical unknown ala-rich protein.
PE_PGRS43 protein networkhttps://string-db.org/network/83332.Rv2490cPE-PGRS family protein PE_PGRS43; Rv2490c, (MTV008.46c), len: 1660 aa. PE_PGRS43,Member of the Mycobacterium tuberculosis PE family,PGRS-subfamily of Gly-rich proteins (see Brennan and Delogu, 20 [...]
Rv2491 protein networkhttps://string-db.org/network/83332.Rv2491Rv2491, (MTV008.47), len: 207 aa. Conserved hypothetical protein, similar in part to other hypothetical proteins e.g. O29139|AF1126 from Archaeoglobus fulgidus (151 aa), FASTA scores: opt: 293, E [...]
Rv2492 protein networkhttps://string-db.org/network/83332.Rv2492Hypothetical protein; Rv2492, (MTV008.48), len: 250 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
vapB38 protein networkhttps://string-db.org/network/83332.Rv2493Possible antitoxin VapB38; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Its putative cognate toxin is VapC38.
vapC38 protein networkhttps://string-db.org/network/83332.Rv2494Possible toxin VapC38. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB38 (By similarity).
bkdC protein networkhttps://string-db.org/network/83332.Rv2495cProbable branched-chain keto acid dehydrogenase E2 component BkdC; Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversion of branched [...]
bkdB protein networkhttps://string-db.org/network/83332.Rv2496cProbable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB; Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall conversi [...]
bkdA protein networkhttps://string-db.org/network/83332.Rv2497cProbable branched-chain keto acid dehydrogenase E1 component, alpha subunit BkdA; Component of the branched-chain alpha-ketoacid dehydrogenase (BCKADH) complex, that catalyzes the overall convers [...]
citE protein networkhttps://string-db.org/network/83332.Rv2498cCitrate lyase subunit beta-like protein; May play a role in fatty acid biosynthesis.
Rv2499c protein networkhttps://string-db.org/network/83332.Rv2499cRv2499c, (MTCY07A7.05c), len: 185 aa. Possible oxidase regulatory-related protein, similar to many maoC monoamine oxidase regulatory protein e.g. Q9RUZ1|DR1239 MAOC-related protein from Deinococc [...]
fadE19 protein networkhttps://string-db.org/network/83332.Rv2500cPossible acyl-CoA dehydrogenase FadE19 (MMGC); Rv2500c, (MTCY07A7.06c), len: 394 aa. Possible fadE19 (alternate gene name: mmgC), acyl-CoA dehydrogenase,similar to many e.g. Q9XCG6|ACDH from Stre [...]
accA1 protein networkhttps://string-db.org/network/83332.Rv2501cAcetyl-/propionyl-coenzyme A carboxylase alpha chain; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.
accD1 protein networkhttps://string-db.org/network/83332.Rv2502cRv2502c, (MTCY07A7.08c), len: 529 aa. Probable accD1, acetyl-/propionyl-CoA carboxylase (beta subunit), similar, but with N-terminus shorter, to Q9L077|ACCD1 from Streptomyces coelicolor (538 aa) [...]
scoB protein networkhttps://string-db.org/network/83332.Rv2503cRv2503c, (MTCY07A7.09c, MT2578), len: 218 aa. Probable scoB, 3-oxo acid:CoA transferase, beta subunit (succinyl-CoA:3-ketoacid-CoA transferase). Highly similar to others e.g. Q9XAM8|SC4C6.12c fro [...]
scoA protein networkhttps://string-db.org/network/83332.Rv2504cRv2504c, (MT2579, MTCY07A7.10c), len: 248 aa. Probable scoA, succinyl-CoA:3-ketoacid-Coenzyme A transferase, alpha subunit (3-oxo acid:CoA transferase). Highly similar to others e.g. Q9XAM7|SC4C6 [...]
fadD35 protein networkhttps://string-db.org/network/83332.Rv2505cProbable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv2505c, (MTCY07A7.11c), len: 547 aa. Probable fadD35, fatty-acid-CoA synthetase, highly similar to ma [...]
Rv2506 protein networkhttps://string-db.org/network/83332.Rv2506Probable transcriptional regulatory protein (probably TetR-family); Rv2506, (MTCY07A7.12), len: 215 aa. Probable transcriptional regulator, TetR family, similar to many others e.g. Q9L078|SCC105. [...]
Rv2507 protein networkhttps://string-db.org/network/83332.Rv2507Rv2507, (MTCY07A7.13), len: 273 aa. Possible conserved pro-rich membrane protein (N-terminal half is Proline-rich), highly similar to Q9CCU3|ML0431 putative membrane protein from Mycobacterium le [...]
Rv2508c protein networkhttps://string-db.org/network/83332.Rv2508cRv2508c, (MTCY07A7.14c), len: 445 aa. Probable conserved integral membrane leu-, ala-rich protein,equivalent to Q9CCU4|ML0430 putative membrane protein from Mycobacterium leprae (454 aa) (alias O [...]
Rv2509 protein networkhttps://string-db.org/network/83332.Rv2509Rv2509, (MTCY07A7.15), len: 268 aa. Probable ala-rich oxidoreductase, short-chain dehydrogenase/reductase, equivalent to O07709|MLCL383.36c|ML0429 dehydrogenase (putative oxidoreductase) from Myc [...]
Rv2510c protein networkhttps://string-db.org/network/83332.Rv2510cConserved protein; Rv2510c, (MTCY07A7.16c), len: 533 aa. Conserved protein, highly similar, but longer approximately 20 aa, to others e.g. Q9ABY0|CC0090 hypothetical protein from Caulobacter cres [...]
orn protein networkhttps://string-db.org/network/83332.Rv2511Oligoribonuclease Orn; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.
Rv2512c protein networkhttps://string-db.org/network/83332.Rv2512cRv2512c, (MTCY07A7.18c), len: 415 aa. Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt [...]
Rv2514c protein networkhttps://string-db.org/network/83332.Rv2514cRv2514c, (MTCY07A7.20c), len: 153 aa. Conserved hypothetical protein, showing some similarity to Q9PG05|XF0497 hypothetical protein from Xylella fastidiosa (155 aa), FASTA scores: opt: 215, E(): [...]
Rv2515c protein networkhttps://string-db.org/network/83332.Rv2515cRv2515c, (MTCY07A7.21c), len: 415 aa. Conserved hypothetical protein, showing some similarity to Q9PG06|XF0496 hypothetical protein from Xylella fastidiosa (391 aa), FASTA scores: opt: 388, E(): [...]
Rv2516c protein networkhttps://string-db.org/network/83332.Rv2516cHypothetical protein; Rv2516c, (MTV009.01c), len: 267 aa. Hypothetical unknown protein. Contains probable helix-turn-helix motif at aa 98 to 119 (Score 1743, +5.12 SD). C-terminus extended since [...]
Rv2517c protein networkhttps://string-db.org/network/83332.Rv2517cUnknown protein; Rv2517c, (MTV009.02c), len: 83 aa. Unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa.
ldtB protein networkhttps://string-db.org/network/83332.Rv2518cProbable L,D-transpeptidase LdtB; Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond betwee [...]
PE26 protein networkhttps://string-db.org/network/83332.Rv2519Rv2519, (MTV009.04), len: 492 aa. PE26, Member of the M. tuberculosis PE family (see citation below), highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa),FASTA scor [...]
Rv2520c protein networkhttps://string-db.org/network/83332.Rv2520cRv2520c, (MTV009.05c), len: 75 aa. Possible conserved membrane protein, equivalent to O07706|MLCL383.32 hypothetical 10.0 KDA protein from Mycobacterium leprae (91 aa), FASTA scores: opt: 290, E( [...]
bcp protein networkhttps://string-db.org/network/83332.Rv2521Probable bacterioferritin comigratory protein Bcp; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Play [...]
Rv2522c protein networkhttps://string-db.org/network/83332.Rv2522cRv2522c, (MTV009.07c), len: 470 aa. Conserved hypothetical protein, equivalent, but longer 20 aa, to Q9X7E4|ML1193|MLCB458.08 from hypothetical 46.6 KDA protein Mycobacterium leprae (442 aa), FAS [...]
acpS protein networkhttps://string-db.org/network/83332.Rv2523cHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
fas protein networkhttps://string-db.org/network/83332.Rv2524cRv2524c, (MTCY159.32, MTV009.09c), len: 3069 aa. Probable fas, Fatty Acid Synthase, equivalent to Q9X7E2|fas|ML1191 putative type I fatty acid synthase from Mycobacterium leprae (3076 aa), FASTA [...]
Rv2525c protein networkhttps://string-db.org/network/83332.Rv2525cConserved hypothetical protein. Secreted; May function as a peptidoglycan hydrolase with glycosidase activity. In vitro, displays esterase activity toward p-nitrophenyl esters of various acyl cha [...]
vapB17 protein networkhttps://string-db.org/network/83332.Rv2526Possible antitoxin VapB17; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC17.
vapC17 protein networkhttps://string-db.org/network/83332.Rv2527Possible toxin VapC17; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB17 (By similarity). Belongs to the PINc/VapC protein family.
mrr protein networkhttps://string-db.org/network/83332.Rv2528cRv2528c, (MTCY159.28), len: 306 aa. Probable mrr,restriction system protein, similar to other mrr proteins e.g. Q9RWS8|DR0587|MRR from Deinococcus radiodurans (306 aa), FASTA scores: opt: 776, E( [...]
Rv2529 protein networkhttps://string-db.org/network/83332.Rv2529Hypothetical protein; Rv2529, (MTCY159.27c), len: 463 aa. Hypothetical unknown protein. Note that C-terminal part is similar to short region of Q53609|MTS1_STRAL|SALIM modification methylase SALI [...]
vapB39 protein networkhttps://string-db.org/network/83332.Rv2530APossible antitoxin VapB39; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC39.
vapC39 protein networkhttps://string-db.org/network/83332.Rv2530cPossible toxin VapC39. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv2531c protein networkhttps://string-db.org/network/83332.Rv2531cRv2531c, (MTCY159.25), len: 947 aa. Probable amino acid decarboxylase, equivalent to Q9CCR8|adi|ML0524 putative amino acid decarboxylase from Mycobacterium leprae (950 aa), FASTA scores: opt: 542 [...]
Rv2532c protein networkhttps://string-db.org/network/83332.Rv2532cHypothetical protein; Rv2532c, (MTCY159.24), len: 133 aa. Hypothetical unknown protein, equivalent to AAK46918 from Mycobacterium tuberculosis strain CDC1551 but shorter 157 aa.
nusB protein networkhttps://string-db.org/network/83332.Rv2533cN utilization substance protein NusB (NusB protein); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antitermin [...]
efp protein networkhttps://string-db.org/network/83332.Rv2534cProbable elongation factor P Efp; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably funct [...]
pepQ protein networkhttps://string-db.org/network/83332.Rv2535cRv2535c, (MTCY159.21), len: 372 aa. Probable pepQ,cytoplasmic peptidase, equivalent to Q9CCS1|PEPQ|ML0521 putative cytoplasmic peptidase from Mycobacterium leprae (376 aa), FASTA scores: opt: 195 [...]
Rv2536 protein networkhttps://string-db.org/network/83332.Rv2536Rv2536, (MTCY159.20c), len: 230 aa. Probable conserved transmembrane protein, equivalent to Q9CCS2|ML0520 putative membrane protein from Mycobacterium leprae (202 aa), FASTA scores: opt: 812, E() [...]
aroD protein networkhttps://string-db.org/network/83332.Rv2537c3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase); Catalyzes a trans-dehydration via an enolate intermediate.
aroB protein networkhttps://string-db.org/network/83332.Rv2538c3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
aroK protein networkhttps://string-db.org/network/83332.Rv2539cShikimate kinase AroK (SK); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Belongs to the shikimate kinase family.
aroF protein networkhttps://string-db.org/network/83332.Rv2540cProbable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate- [...]
Rv2541 protein networkhttps://string-db.org/network/83332.Rv2541Rv2541, (MTCY159.15c), len: 135 aa. Hypothetical unknown ala-rich protein, equivalent to AAK46926|MT2615.1 hypothetical 38.9 KDA protein from Mycobacterium tuberculosis strain CDC1551 but AAK4692 [...]
Rv2542 protein networkhttps://string-db.org/network/83332.Rv2542Rv2542, (MTCY159.14c), len: 403 aa. Conserved hypothetical protein, highly similar to AAK46927|MT2616 hypothetical 28.0 KDA protein from Mycobacterium tuberculosis strain CDC1551 (265 aa), FASTA [...]
lppA protein networkhttps://string-db.org/network/83332.Rv2543Rv2543, (MTCY159.13c), len: 219 aa. Probable lppA,conserved lipoprotein, highly similar to upstream ORF P95009|LPPB|Rv2544|MTCY159.12 putative lipoprotein LPPB from Mycobacterium tuberculosis (22 [...]
lppB protein networkhttps://string-db.org/network/83332.Rv2544Rv2544, (MTCY159.12c), len: 220 aa. Probable lppB,conserved lipoprotein, highly similar to downstream ORF P95010|MTCY159.13c|LPPA|Rv2543|MTCY159.13 putative lipoprotein LPPA from Mycobacterium tu [...]
vapB18 protein networkhttps://string-db.org/network/83332.Rv2545Possible antitoxin VapB18; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC18.
vapC18 protein networkhttps://string-db.org/network/83332.Rv2546Possible toxin VapC18; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB18 (By similarity). Belongs to the PINc/VapC protein family.
vapB19 protein networkhttps://string-db.org/network/83332.Rv2547Possible antitoxin VapB19; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC19.
vapC19 protein networkhttps://string-db.org/network/83332.Rv2548Possible toxin VapC19; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralize [...]
Rv2548A protein networkhttps://string-db.org/network/83332.Rv2548ARv2548A, len: 124 aa. Conserved protein.
vapC20 protein networkhttps://string-db.org/network/83332.Rv2549cPossible toxin VapC20; Toxic component of a type II toxin-antitoxin (TA) system. An endoribonuclease that cleaves both E.coli and M.smegmatis 23S rRNA between G2661 and A2662 in the sarcin-ricin [...]
vapB20 protein networkhttps://string-db.org/network/83332.Rv2550cPossible antitoxin VapB20; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the toxic effect of cognate toxin VapC20.
Rv2551c protein networkhttps://string-db.org/network/83332.Rv2551cRv2551c, (MTCY159.05), len: 139 aa. Conserved hypothetical protein, similar to the second part of Q9XAP1|SC10A7.34c putative type IV peptidase from Streptomyces coelicolor (259 aa), FASTA scores: [...]
aroE protein networkhttps://string-db.org/network/83332.Rv2552cRv2552c, (MTCY159.04), len: 269 aa. Probable aroE,shikimate 5-dehydrogenase, equivalent to Q9CCS7|AROE|ML0515 putative shikimate 5-dehydrogenase from Mycobacterium leprae (278 aa), FASTA scores: [...]
mltG protein networkhttps://string-db.org/network/83332.Rv2553cProbable conserved membrane protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase [...]
Rv2554c protein networkhttps://string-db.org/network/83332.Rv2554cConserved protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
alaS protein networkhttps://string-db.org/network/83332.Rv2555cProbable alanyl-tRNA synthetase AlaS (alanine--tRNA ligase) (alanine translase) (ALARS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by AT [...]
Rv2556c protein networkhttps://string-db.org/network/83332.Rv2556cRv2556c, (MTCY09C4.12), len: 129 aa. Conserved hypothetical protein, highly similar to others e.g. Q9EWY5|2SCG38.34 conserved hypothetical protein from Streptomyces coelicolor (140 aa), FASTA sco [...]
Rv2557 protein networkhttps://string-db.org/network/83332.Rv2557Conserved protein; Rv2557, (MTCY9C4.11c), len: 224 aa. Conserved protein, highly similar to upstream ORF Q50740|MTCY9C4.10c|Rv2558|MT2635 conserved hypothetical protein from Mycobacterium tubercu [...]
Rv2558 protein networkhttps://string-db.org/network/83332.Rv2558Conserved protein; Rv2558, (MTCY9C4.10c), len: 236 aa. Conserved protein, highly similar to downstream ORF Q50741|MTCY9C4.11c|Rv2557|MT2645 conserved hypothetical protein from Mycobacterium tuber [...]
Rv2559c protein networkhttps://string-db.org/network/83332.Rv2559cRv2559c, (MTCY9C4.09), len: 452 aa. Conserved hypothetical ala-, leu-, val-rich protein, equivalent to Q9CCT1|ML0510 hypothetical protein from Mycobacterium leprae (473 aa), FASTA scores: opt: 24 [...]
Rv2560 protein networkhttps://string-db.org/network/83332.Rv2560Rv2560, (MTCY9C4.08c), len: 325 aa. Probable transmembrane protein, pro-, gly-rich protein.
Rv2561 protein networkhttps://string-db.org/network/83332.Rv2561Rv2561, (MTCY9C4.07c), len: 97 aa. Conserved hypothetical protein, highly similar in part (and longer 33 aa) to upstream ORF AAK46951|RV2562|MT2638|MTCY9C4.06c conserved hypothetical protein from [...]
Rv2562 protein networkhttps://string-db.org/network/83332.Rv2562Rv2562, (MTCY9C4.06c), len: 129 aa. Conserved hypothetical protein, highly similar, but shorter 83 aa, to downstream ORF AAK46951|RV2561|MT2638|MTCY9C4.07c conserved hypothetical protein from Myc [...]
Rv2563 protein networkhttps://string-db.org/network/83332.Rv2563Rv2563, (MTCY9C4.05c), len: 349 aa. Probable glutamine-transport transmembrane protein ABC transporter (see citation below), highly similar to O53617|Rv0072|MTV030.16 putative ABC-transporter tra [...]
glnQ protein networkhttps://string-db.org/network/83332.Rv2564Rv2564, (MTCY9C4.04c), len: 330 aa. Probable glnQ,glutamine-transport ATP-binding protein ABC transporter (see citation below), highly similar to many e.g. Q9L0J9|SCD40A.12c putative ABC-transpor [...]
Rv2565 protein networkhttps://string-db.org/network/83332.Rv2565Conserved protein; Rv2565, (MTCY9C4.03c), len: 583 aa. Conserved protein, similar in part to Q9A6C3|CC2171 hypothetical protein from Caulobacter crescentus (610 aa), FASTA scores: opt: 765, E(): [...]
Rv2566 protein networkhttps://string-db.org/network/83332.Rv2566Long conserved protein; Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved protein, equivalent to O53120|ML2678 or MLCB1913.12 hypothetical protein from Mycobacterium leprae (1000 aa),FASTA scor [...]
Rv2567 protein networkhttps://string-db.org/network/83332.Rv2567Rv2567, (MTCY227.34c, MTCY9C4.01c), len: 884 aa. Conserved hypothetical ala-, leu-rich protein, equivalent to O53121|ML2679|MLCB1913.13 hypothetical protein from Mycobacterium leprae (893 aa), FA [...]
Rv2568c protein networkhttps://string-db.org/network/83332.Rv2568cRv2568c, (MTCY227.33), len: 341 aa. Conserved hypothetical protein, highly similar (but longer 60 aa) to Q98E75|MLR4376 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (308 aa), FAS [...]
Rv2569c protein networkhttps://string-db.org/network/83332.Rv2569cRv2569c, (MTCY227.32), len: 314 aa. Conserved hypothetical protein, equivalent to Q9CCT2|ML0508 hypothetical protein from Mycobacterium leprae (313 aa),FASTA scores: opt: 1723, E(): 1.9e-95, (84. [...]
Rv2570 protein networkhttps://string-db.org/network/83332.Rv2570Rv2570, (MTCY227.31c), len: 129 aa. Conserved hypothetical protein, similar to Q98GQ7|MLR3218 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (133 aa), FASTA scores: opt: 174, E(): [...]
Rv2571c protein networkhttps://string-db.org/network/83332.Rv2571cProbable transmembrane alanine and valine and leucine rich protein; Rv2571c, (MTCY227.30), len: 355 aa. Probable transmembrane ala-, val-, leu-rich protein, showing some similarity with other mem [...]
aspS protein networkhttps://string-db.org/network/83332.Rv2572cProbable aspartyl-tRNA synthetase AspS (aspartate--tRNA ligase) (ASPRS) (aspartic acid translase); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only [...]
Rv2573 protein networkhttps://string-db.org/network/83332.Rv2573Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
Rv2574 protein networkhttps://string-db.org/network/83332.Rv2574Conserved protein; Rv2574, (MTCY227.27c), len: 167 aa. Conserved protein, showing similarity with Q9K3N3|SCG20A.07 hypothetical 17.4 KDA protein from Streptomyces coelicolor (157 aa), FASTA score [...]
Rv2575 protein networkhttps://string-db.org/network/83332.Rv2575Rv2575, (MTCY227.26c), len: 293 aa. Possible conserved membrane gly-rich protein, highly similar to hypothetical proteins e.g. Q9RR98|DR2596 conserved hypothetical protein from Deinococcus radiod [...]
Rv2576c protein networkhttps://string-db.org/network/83332.Rv2576cRv2576c, (MTCY227.25), len: 154 aa. Possible conserved membrane protein, showing similarity with Q9ZFC2 hypothetical 15.7 KDA protein from Mycobacterium sp. FM10 (146 aa), FASTA scores: opt: 235, [...]
Rv2577 protein networkhttps://string-db.org/network/83332.Rv2577Conserved protein; Rv2577, (MTCY227.24c), len: 529 aa. Conserved protein, showing similarity with various proteins from eukaryotes, in particular phosphatases, e.g. Q9SE01|pap purple acid phospha [...]
Rv2578c protein networkhttps://string-db.org/network/83332.Rv2578cRv2578c, (MTCY227.23), len: 340 aa. Conserved hypothetical protein, highly similar to hypothetical proteins (conserved or not) e.g. Q9ZBJ3|SC9C7.17c from Streptomyces coelicolor (348 aa), FASTA s [...]
dhaA protein networkhttps://string-db.org/network/83332.Rv2579Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase); Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the c [...]
hisS protein networkhttps://string-db.org/network/83332.Rv2580cRv2580c, (MT2657, MTCY227.21), len: 423 aa. Probable hisS, histidyl-tRNA synthetase, equivalent to P46696|SYH_MYCLE|hiss|ML0494|MLCB1259.12|B1177_C3_248 histidyl-tRNA synthetase from Mycobacteriu [...]
Rv2581c protein networkhttps://string-db.org/network/83332.Rv2581cPossible glyoxalase II (hydroxyacylglutathione hydrolase) (GLX II); Rv2581c, (MTCY227.20), len: 224 aa. Possible glyoxalase II, equivalent to Q49649|YP81_MYCLE|ML0493|MLCB1259.11|B1177_C3_247 hyp [...]
ppiB protein networkhttps://string-db.org/network/83332.Rv2582Probable peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarit [...]
relA protein networkhttps://string-db.org/network/83332.Rv2583cGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cell [...]
apt protein networkhttps://string-db.org/network/83332.Rv2584cAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Rv2585c protein networkhttps://string-db.org/network/83332.Rv2585cPossible conserved lipoprotein; Rv2585c, (MT2662, MTCY227.16), len: 557 aa. Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding pro [...]
secF protein networkhttps://string-db.org/network/83332.Rv2586cProbable protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to co [...]
secD protein networkhttps://string-db.org/network/83332.Rv2587cProbable protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to co [...]
yajC protein networkhttps://string-db.org/network/83332.Rv2588cProbable conserved membrane protein secretion factor YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion [...]
gabT protein networkhttps://string-db.org/network/83332.Rv25894-aminobutyrate aminotransferase; Rv2589, (MTCY227.12c), len: 449 aa. Probable gabT,4-aminobutyrate aminotransferase, equivalent to P40829|GABT_MYCLE|ML0485|MLCB1259.03c|B1177_F2_67 4-aminobutyra [...]
fadD9 protein networkhttps://string-db.org/network/83332.Rv2590Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Rv2590, (MTCY227.11c), len: 1168 aa. Probable fadD9,fatty-acid-CoA synthetase, highly similar to O69484 [...]
PE_PGRS44 protein networkhttps://string-db.org/network/83332.Rv2591PE-PGRS family protein PE_PGRS44; Rv2591, (MTCY227.10c), len: 543 aa. PE_PGRS44,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highl [...]
ruvB protein networkhttps://string-db.org/network/83332.Rv2592cProbable holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promo [...]
ruvA protein networkhttps://string-db.org/network/83332.Rv2593cProbable holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promo [...]
ruvC protein networkhttps://string-db.org/network/83332.Rv2594cCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to st [...]
vapB40 protein networkhttps://string-db.org/network/83332.Rv2595Possible antitoxin VapB40; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC40. Upon expression in E.coli partially counteracts the ribonuclease activity of [...]
vapC40 protein networkhttps://string-db.org/network/83332.Rv2596Possible toxin VapC40. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Its cognate antitoxin is VapB40.
Rv2597 protein networkhttps://string-db.org/network/83332.Rv2597Probable membrane protein; Rv2597, (MTCY227.04c), len: 206 aa. Probable membrane protein. Predicted to be an outer membrane protein (See Song et al., 2008).
Rv2598 protein networkhttps://string-db.org/network/83332.Rv2598Rv2598, (MTCY227.03c), len: 164 aa. Conserved hypothetical protein, showing similarity with hypothetical proteins from Streptomyces coelicolor e.g. Q9X8S3|SCH10.34c (185 aa), FASTA scores: opt: 1 [...]
Rv2599 protein networkhttps://string-db.org/network/83332.Rv2599Rv2599, (MTCY227.02c), len: 143 aa. Probable conserved membrane protein, equivalent to Q9K536|2599 hypothetical 15.0 KDA protein (fragment) from Mycobacterium paratuberculosis (143 aa), FASTA sco [...]
Rv2600 protein networkhttps://string-db.org/network/83332.Rv2600Rv2600, (MTCY277.01c, MTV001.01), len: 133 aa. Probable conserved integral membrane protein, equivalent (but shorter 18 aa) to Q9K537|YQ00_MYCPA hypothetical protein RV2600 homolog from Mycobacte [...]
speE protein networkhttps://string-db.org/network/83332.Rv2601Polyamine aminopropyltransferase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to [...]
vapB41 protein networkhttps://string-db.org/network/83332.Rv2601APossible antitoxin VapB41; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC41.
vapC41 protein networkhttps://string-db.org/network/83332.Rv2602Possible toxin VapC41. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
Rv2603c protein networkhttps://string-db.org/network/83332.Rv2603cHighly conserved protein; Rv2603c, (MTCI270A.02), len: 251 aa. Highly conserved protein, equivalent to Q49645|YQ03_MYCLE|ML0475|U1177B|B1177_C2_181 hypothetical 26.6 KDA protein from Mycobacteriu [...]
snoP protein networkhttps://string-db.org/network/83332.Rv2604cProbable glutamine amidotransferase SnoP; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is c [...]
tesB2 protein networkhttps://string-db.org/network/83332.Rv2605cRv2605c, (MTCY01A10.28), len: 281 aa. Probable tesB2, acyl-CoA thioesterase II, highly similar to others e.g. Q98EG9|MLL4250 from Rhizobium loti (Mesorhizobium loti) (286 aa), FASTA scores: opt: [...]
snzP protein networkhttps://string-db.org/network/83332.Rv2606cPossible pyridoxine biosynthesis protein SnzP; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provid [...]
pdxH protein networkhttps://string-db.org/network/83332.Rv2607Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of pyridoxine 5'-phosphate (PNP) into pyridoxal 5'-phosphate (PLP). Unlike many PNPOx enzymes, Rv2607 does not recognize pyridoxamine 5'-p [...]
PPE42 protein networkhttps://string-db.org/network/83332.Rv2608PPE family protein PPE42; Elicits a high humoral and a low T-cell response. Could be involved in directing the host toward development of a more humoral type of immune response; Belongs to the my [...]
Rv2609c protein networkhttps://string-db.org/network/83332.Rv2609cRv2609c, (MTCY01A10.24), len: 351 aa. Probable conserved membrane protein, equivalent to O07146|MLCL581.13c|ML0451 hypothetical 37.9 KDA protein from Mycobacterium leprae (349 aa), FASTA scores: [...]
pimA protein networkhttps://string-db.org/network/83332.Rv2610cAlpha-mannosyltransferase PimA; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannan [...]
Rv2611c protein networkhttps://string-db.org/network/83332.Rv2611cProbable acyltransferase; Catalyzes the acylation to the position 6 of the alpha-1,2- linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1).
pgsA1 protein networkhttps://string-db.org/network/83332.Rv2612cPhosphatidylinositol phosphate synthase; Catalyzes the conjugation of the 1'-hydroxyl group of D-myo- inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine di [...]
Rv2613c protein networkhttps://string-db.org/network/83332.Rv2613cConserved protein; Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside [...]
Rv2614A protein networkhttps://string-db.org/network/83332.Rv2614ARv2614A, len: 75 aa. Conserved hypothetical protein. The region from aa 10-35 is similar to part of C-terminal part of several triosephosphate isomerases e.g. P46711|TPIS_MYCLE|TPIA|TPI|ML0572|B1 [...]
thrS protein networkhttps://string-db.org/network/83332.Rv2614cProbable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first [...]
PE_PGRS45 protein networkhttps://string-db.org/network/83332.Rv2615cPE-PGRS family protein PE_PGRS45; Rv2615c, (MTCY01A10.19), len: 461 aa. PE_PGRS45,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), hig [...]
Rv2616 protein networkhttps://string-db.org/network/83332.Rv2616Conserved protein; Rv2616, (MTCY01A10.18c), len: 166 aa. Conserved protein, highly similar to bacterial proteins: Q9L1G0|SC3D11.02c hypothetical 20.3 KDA protein from Streptomyces coelicolor (188 [...]
Rv2617c protein networkhttps://string-db.org/network/83332.Rv2617cRv2617c, (MTCY01A10.17), len: 146 aa. Probable transmembrane protein, showing some similarity to hypothetical or membrane proteins e.g. CAC47207|SMC00744 putative transport protein transmembrane [...]
Rv2618 protein networkhttps://string-db.org/network/83332.Rv2618Rv2618, (MTCY01A10.15c), len: 225 aa. Conserved hypothetical protein, similar in part to Q9EWQ9|SC4C2.03 conserved hypothetical protein from Streptomyces coelicolor (159 aa), FASTA scores: opt: 2 [...]
Rv2619c protein networkhttps://string-db.org/network/83332.Rv2619cConserved protein; Rv2619c, (MTCY01A10.14), len: 117 aa. Conserved protein, highly similar to Q9L0F3|SCD31.14 hypothetical 11.6 KDA protein from Streptomyces coelicolor (110 aa),FASTA scores: opt [...]
Rv2620c protein networkhttps://string-db.org/network/83332.Rv2620cRv2620c, (MTCY01A10.13), len: 141 aa. Probable conserved transmembrane protein, highly similar to O54184|SC7H1.25 hypothetical 14.6 KDA protein from Streptomyces coelicolor (144 aa), FASTA scores [...]
Rv2621c protein networkhttps://string-db.org/network/83332.Rv2621cRv2621c, (MTCY01A10.11), len: 224 aa. Possible transcriptional regulator, similar in part to Q49688|MLCL536.29c|ML0592 putative DNA-binding protein from Mycobacterium leprae (254 aa), FASTA score [...]
Rv2622 protein networkhttps://string-db.org/network/83332.Rv2622Rv2622, (MTCY01A10.10c), len: 273 aa. Possible methyltransferase, similar in part to others e.g. AAK75664|SP1578 putative methyltransferase from Streptococcus pneumoniae (252 aa), FASTA scores: o [...]
TB31.7 protein networkhttps://string-db.org/network/83332.Rv2623Universal stress protein family protein TB31.7; May play a role in the establishment of a persistent infection (latency) in the host, as strains without this gene are hypervirulent. Overexpressio [...]
Rv2624c protein networkhttps://string-db.org/network/83332.Rv2624cRv2624c, (MTCY01A10.08), len: 272 aa. Universal stress protein family protein, similar to several Streptomyces proteins e.g. Q9RIY5|SCJ1.29c hypothetical 30.1 KDA protein from Streptomyces coelic [...]
rip3 protein networkhttps://string-db.org/network/83332.Rv2625cRv2625c, (MTCY01A10.07), len: 393 aa. Probable conserved transmembrane ala-, leu-rich protein, similar to many hypothetical or membrane proteins e.g. Q55518|Y528_SYNY3|SLL0528 potential integral [...]
hrp1 protein networkhttps://string-db.org/network/83332.Rv2626cHypoxic response protein 1 Hrp1; Unlike some other CBS-domain containing proteins does not seem to bind AMP.
Rv2627c protein networkhttps://string-db.org/network/83332.Rv2627cConserved protein; Rv2627c, (MTCY01A10.05), len: 413 aa. Conserved protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c hypothetical 44.0 KDA protein from Mycobacterium tuberc [...]
Rv2628 protein networkhttps://string-db.org/network/83332.Rv2628Hypothetical protein; Rv2628, (MTCY01A10.04c), len: 120 aa. Hypothetical unknown protein. Predicted possible vaccine candidate (See Zvi et al., 2008).
Rv2629 protein networkhttps://string-db.org/network/83332.Rv2629Conserved protein; Rv2629, (MTCY01A10.03c), len: 374 aa. Conserved protein, similar to Q9ZC00|SC1E6.22c hypothetical 40.7 KDA protein from Streptomyces coelicolor (373 aa), FASTA scores: opt: 425 [...]
Rv2630 protein networkhttps://string-db.org/network/83332.Rv2630Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate [...]
rtcB protein networkhttps://string-db.org/network/83332.Rv2631Conserved hypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends.
Rv2632c protein networkhttps://string-db.org/network/83332.Rv2632cConserved protein; Rv2632c, (MTCY441.02c), len: 93 aa. Conserved protein, highly similar to conserved hypothetical proteins from Mycobacterium tuberculosis: P71996|YH38_MYCTU|Rv1738|MT1780|MTCY04 [...]
Rv2633c protein networkhttps://string-db.org/network/83332.Rv2633cHypothetical protein; Rv2633c, (MTCY441.03c), len: 161 aa. Hypothetical unknown protein.
PE_PGRS46 protein networkhttps://string-db.org/network/83332.Rv2634cPE-PGRS family protein PE_PGRS46; Rv2634c, (MTCY441.04c), len: 778 aa. PE_PGRS46,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), high [...]
Rv2635 protein networkhttps://string-db.org/network/83332.Rv2635Hypothetical protein; Rv2635, (MTCY441.05), len: 80 aa. Hypothetical unknown protein.
Rv2636 protein networkhttps://string-db.org/network/83332.Rv2636Rv2636, (MTCY441.06), len: 225 aa. Conserved hypothetical protein, showing some similarity with various proteins: Q98FG2|MLL3789 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (239 [...]
dedA protein networkhttps://string-db.org/network/83332.Rv2637Rv2637, (MTCY441.07), len: 218 aa. Possible dedA,transmembrane protein, equivalent to Q49642|YQ37_MYCLE|ML0467|MLCL581.27|B1177_C2_172/B1177_C1_ 140 hypothetical 23.1 KDA protein (potential integ [...]
Rv2638 protein networkhttps://string-db.org/network/83332.Rv2638Rv2638, (MTCY441.08), len: 148 aa. Conserved hypothetical protein, similar in part to Q9WVX8|RSBV_STRCO|bldg|SCH5.12c anti-sigma B factor antagonist from Streptomyces coelicolor (113 aa), FASTA s [...]
Rv2639c protein networkhttps://string-db.org/network/83332.Rv2639cRv2639c, (MTCY441.09c), len: 110 aa. Probable conserved integral membrane protein, highly similar to many bacterial hypothetical or membrane proteins e.g. Q9X889|YE14_STRCO|SCE15.14 potential int [...]
Rv2640c protein networkhttps://string-db.org/network/83332.Rv2640cPossible transcriptional regulatory protein (probably ArsR-family); Rv2640c, (MTCY441.10c), len: 119 aa. Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9L1V5|SC4A9. [...]
cadI protein networkhttps://string-db.org/network/83332.Rv2641Cadmium inducible protein CadI; Rv2641, (MTCY441.11), len: 152 aa. CadI, conserved hypothetical protein. Gene induced by cadmium (see Hotter et al., 2001), highly similar to hypothetical proteins [...]
Rv2642 protein networkhttps://string-db.org/network/83332.Rv2642Possible transcriptional regulatory protein (probably ArsR-family); Rv2642, (MTCY441.12), len: 126 aa. Possible transcriptional regulator, arsR family, highly similar to many e.g. Q9X8X8|SCH35.28 [...]
arsC protein networkhttps://string-db.org/network/83332.Rv2643Rv2643, (MTCY441.13), len: 498 aa. Probable arsC,arsenical resistance transport integral membrane protein,highly similar or similar to others e.g. Q9L1X4|SC3D9.05 possible arsenic resistance memb [...]
Rv2645 protein networkhttps://string-db.org/network/83332.Rv2645Hypothetical protein; Rv2645, (MTCY441.15), len: 143 aa. Hypothetical unknown protein.
Rv2646 protein networkhttps://string-db.org/network/83332.Rv2646Probable integrase; Rv2646, (MTCY441.16), len: 332 aa. Probable integrase, similar to others e.g. P06723|VINT_BP186|int integrase from Bacteriophage 186 (336 aa)s FASTA scores: opt: 198, E(): 6.3 [...]
Rv2647 protein networkhttps://string-db.org/network/83332.Rv2647Hypothetical protein; Rv2647, (MTCY441.17), len: 122 aa (questionable ORF). Hypothetical protein, probably corresponds to conserved DNA sequence also found in MTCY336.29c and Rv1574|MTCY336.30c|O [...]
Rv2648 protein networkhttps://string-db.org/network/83332.Rv2648Rv2648, (MTCY441.17A), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by [...]
Rv2649 protein networkhttps://string-db.org/network/83332.Rv2649Rv2649, (MTCY441.18), len: 328 aa. Probable transposase for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shif [...]
Rv2650c protein networkhttps://string-db.org/network/83332.Rv2650cRv2650c, (MTCY441.19), len: 479 aa. Possible phiRv2 prophage protein (capsid subunit) (see citation below),highly similar to O06614|Rv1576c|MTCY336.28 probable phiRv1 phage protein from Mycobacte [...]
Rv2651c protein networkhttps://string-db.org/network/83332.Rv2651cRv2651c, (MTCY441.20c), len: 177 aa. Possible protease protein, phiRv2 phage protein (prohead protease) (see citation below), showing some similarity with several proteases e.g. Q9A4P4|CC2786 put [...]
Rv2652c protein networkhttps://string-db.org/network/83332.Rv2652cRv2652c, (MTCY441.21c), len: 208 aa. Probable phiRv2 phage protein (terminase) (see citation below), showing some similarity with AAK79859|Q97HW1|CAC1896 phage terminase-like protein (small subun [...]
Rv2653c protein networkhttps://string-db.org/network/83332.Rv2653cPossible PhiRv2 prophage protein; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpressi [...]
Rv2654c protein networkhttps://string-db.org/network/83332.Rv2654cPossible PhiRv2 prophage protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin Rv2653c.
Rv2655c protein networkhttps://string-db.org/network/83332.Rv2655cPossible PhiRv2 prophage protein; Rv2655c, (MTCY441.24c), len: 475 aa. Hypothetical protein, possibly phiRv2 phage protein (putative primase-like protein) (see citation below). C-terminus similar [...]
Rv2656c protein networkhttps://string-db.org/network/83332.Rv2656cPossible PhiRv2 prophage protein; Rv2656c, (MTCY441.25c), len: 130 aa. Probable phiRv2 phage protein (see Hatfull 2000), highly similar to O06607|YF83_MYCTU|Rv1583c|MT3573.2|MTCY336.21 Probable p [...]
Rv2657c protein networkhttps://string-db.org/network/83332.Rv2657cRv2657c, (MTCY441.26c), len: 86 aa. Probable phiRv2 phage protein (excisionase) (see citation below), similar to O22001|VG36_BPMD2|36|G2 gene 36 protein (GP36) from Mycobacteriophage D29 (56 aa), [...]
Rv2658c protein networkhttps://string-db.org/network/83332.Rv2658cPossible prophage protein; Rv2658c, (MTCY441.27c), len: 120 aa. Hypothetical unknown protein, probably phage protein.
Rv2659c protein networkhttps://string-db.org/network/83332.Rv2659cProbable PhiRv2 prophage integrase; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also nec [...]
Rv2660c protein networkhttps://string-db.org/network/83332.Rv2660cHypothetical protein; Rv2660c, (MTCY441.29c), len: 75 aa (questionable orf). Hypothetical unknown protein.
Rv2661c protein networkhttps://string-db.org/network/83332.Rv2661cHypothetical protein; Rv2661c, (MTCY441.30c), len: 129 aa. Hypothetical unknown protein.
Rv2662 protein networkhttps://string-db.org/network/83332.Rv2662Hypothetical protein; Rv2662, (MTCY441.31), len: 90 aa. Hypothetical unknown protein.
Rv2663 protein networkhttps://string-db.org/network/83332.Rv2663Hypothetical protein; Rv2663, (MTCY441.32), len: 77 aa. Hypothetical unknown protein.
Rv2664 protein networkhttps://string-db.org/network/83332.Rv2664Hypothetical protein; Rv2664, (MTCY441.33), len: 84 aa. Hypothetical protein. Some weak similarity to nearby P71964|Rv2667|clpX'|MT2741|MTCY441.36 possible ATP-dependent protease ATP-binding subu [...]
Rv2665 protein networkhttps://string-db.org/network/83332.Rv2665Rv2665, (MTCY441.34), len: 93 aa. Hypothetical arg-rich protein, showing some similarity to N-terminus of P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein from Mycobacterium tuberculosis [...]
Rv2666 protein networkhttps://string-db.org/network/83332.Rv2666Probable transposase for insertion sequence element IS1081 (fragment); Required for the transposition of the insertion element.
clpC2 protein networkhttps://string-db.org/network/83332.Rv2667Rv2667, (MTCY441.36), len: 252 aa. Possible clpC2,ATP-dependent protease atp-binding subunit, highly similar to Q9X8L2|SCE9.40 hypothetical 27.3 KDA protein from Streptomyces coelicolor (258 aa), [...]
Rv2668 protein networkhttps://string-db.org/network/83332.Rv2668Possible exported alanine and valine rich protein; Rv2668, (MTCY441.37), len: 173 aa. Hypothetical ala-, val-rich protein, possibly exported. Equivalent to AAK47057 from Mycobacterium tuberculosi [...]
Rv2669 protein networkhttps://string-db.org/network/83332.Rv2669GCN5-related N-acetyltransferase; Rv2669, (MTCY441.38), len: 156 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Similarity to se [...]
Rv2670c protein networkhttps://string-db.org/network/83332.Rv2670cRv2670c, (MTCY441.39c), len: 369 aa. Conserved hypothetical protein, equivalent, but longer 164 aa, to O05683|MLC1351.22c hypothetical 17.3 KDA protein from Mycobacterium leprae (160 aa), FASTA s [...]
ribD protein networkhttps://string-db.org/network/83332.Rv2671Rv2671, (MTCY441.40), len: 258 aa. Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein incuding diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-ami [...]
Rv2672 protein networkhttps://string-db.org/network/83332.Rv2672Rv2672, (MTCY441.41), len: 528 aa. Possible secreted protease, equivalent to O05685|MLC1351.24|ML1339 putative secreted protease from Mycobacterium leprae (525 aa), FASTA scores: opt: 2722, E(): [...]
aftC protein networkhttps://string-db.org/network/83332.Rv2673Possible arabinofuranosyltransferase AftC; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of th [...]
msrB protein networkhttps://string-db.org/network/83332.Rv2674Peptide-methionine (R)-S-oxide reductase; Rv2674, (MTCY441.43), len: 136 aa. Probable msrB,peptide methionine sulfoxide reductase (See Lee et al.,2008), highly similar to various proteins e.g. Q9 [...]
Rv2675c protein networkhttps://string-db.org/network/83332.Rv2675cRv2675c, (MTCY441.44c), len: 250 aa. Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA scores: opt: 284, E(): 4.6e-11, (68.25% id [...]
Rv2676c protein networkhttps://string-db.org/network/83332.Rv2676cConserved protein; Rv2676c, (MTCY441.45c), len: 231 aa. Conserved protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) hypothetical protein from Mycobacterium leprae (231 a [...]
hemY protein networkhttps://string-db.org/network/83332.Rv2677cProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
hemE protein networkhttps://string-db.org/network/83332.Rv2678cProbable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyr [...]
echA15 protein networkhttps://string-db.org/network/83332.Rv2679Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv2679, (MTV010.03), len: 276 aa. Probable echA15,enoyl-CoA hydratase, similar to P53526|ECHC_MYC [...]
Rv2680 protein networkhttps://string-db.org/network/83332.Rv2680Conserved protein; Rv2680, (MTV010.04), len: 210 aa. Conserved protein,equivalent to Q50005|ML1041|U1764V hypothetical protein from Mycobacterium leprae (196 aa), FASTA scores: opt: 1136, E(): 9. [...]
Rv2681 protein networkhttps://string-db.org/network/83332.Rv2681Rv2681, (MTCY05A6.02), len: 438 aa. Conserved hypothetical ala-rich protein, equivalent to Q50004|ML1040|U1764U hypothetical protein from Mycobacterium leprae (429 aa), FASTA scores: opt: 2146,E( [...]
dxs1 protein networkhttps://string-db.org/network/83332.Rv2682c1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (D [...]
Rv2683 protein networkhttps://string-db.org/network/83332.Rv2683Conserved protein; Rv2683, (MTCY05A6.04), len: 165 aa. Conserved protein, equivalent, but shorter 19 aa, to Q49999|ML1037|U1764Q hypothetical protein from Mycobacterium leprae (184 aa), FASTA sco [...]
arsA protein networkhttps://string-db.org/network/83332.Rv2684Rv2684, (MTCY05A6.05), len: 429 aa. Probable arsA,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable integral membrane protein (antigen 45, a tran [...]
arsB1 protein networkhttps://string-db.org/network/83332.Rv2685Rv2685, (MTCY05A6.06), len: 428 aa. Probable arsB1,arsenic-transport integral membrane protein, equivalent to P46838|AG45_MYCLE|ML1036 46 KDA probable integral membrane protein (antigen 45, a tra [...]
Rv2686c protein networkhttps://string-db.org/network/83332.Rv2686cAntibiotic-transport integral membrane leucine and alanine and valine rich protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export [...]
Rv2687c protein networkhttps://string-db.org/network/83332.Rv2687cAntibiotic-transport integral membrane leucine and valine rich protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers re [...]
Rv2688c protein networkhttps://string-db.org/network/83332.Rv2688cAntibiotic-transport ATP-binding protein ABC transporter; Part of the ABC transporter complex Rv2686c/Rv2687c/Rv2688c involved in fluoroquinolones export. Confers resistance to ciprofloxacin and, [...]
Rv2689c protein networkhttps://string-db.org/network/83332.Rv2689cConserved alanine and valine and glycine rich protein; Rv2689c, (MTCY05A6.10c), len: 405 aa (other less probable starts possible). Conserved ala-, val-, gly-rich protein, similar to O54099|SC10A5 [...]
Rv2690c protein networkhttps://string-db.org/network/83332.Rv2690cRv2690c, (MTCY05A6.11c), len: 657 aa. Probable conserved integral membrane ala-, val-, leu-rich protein,highly similar to others e.g. O54098|SC10A5.05 putative membrane protein from Streptomyces [...]
ceoB protein networkhttps://string-db.org/network/83332.Rv2691Rv2691, (MTCY05A6.12), len: 227 aa. CeoB (alternate gene name: trkA), TRK system potassium uptake protein (see citation below), highly similar to others e.g. Q53949|TRKA_STRCO|SC2E9.17c from Stre [...]
ceoC protein networkhttps://string-db.org/network/83332.Rv2692TRK system potassium uptake protein CeoC; Part of a potassium transport system.
Rv2693c protein networkhttps://string-db.org/network/83332.Rv2693cRv2693c, (MTCY05A6.14c), len: 223 aa. Probable conserved integral membrane ala-, leu-rich protein, showing some similarity to O54140|SC2E9.15 hypothetical 29.6 KDA protein from Streptomyces coeli [...]
Rv2694c protein networkhttps://string-db.org/network/83332.Rv2694cConserved protein; Rv2694c, (MTCY05A6.15c), len: 122 aa. Conserved protein, highly similar in part to SC2E9.14 hypothetical 16.9 KDA protein from Streptomyces coelicolor (154 aa),FASTA scores: op [...]
Rv2695 protein networkhttps://string-db.org/network/83332.Rv2695Rv2695, (MTCY05A6.16), len: 235 aa. Conserved hypothetical ala-rich protein, equivalent to Q49994|ML1030|U1764L hypothetical protein from Mycobacterium leprae (232 aa), FASTA scores: opt: 1166,E( [...]
Rv2696c protein networkhttps://string-db.org/network/83332.Rv2696cConserved alanine and glycine and valine rich protein; Rv2696c, (MTCY05A6.17c), len: 259 aa. Conserved ala-, gly-, val-rich protein, equivalent (but shorter 18 aa) to Q49993|ML1029|U1764K hypothe [...]
dut protein networkhttps://string-db.org/network/83332.Rv2697cDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intrace [...]
Rv2698 protein networkhttps://string-db.org/network/83332.Rv2698Rv2698, (MTCY05A6.19), len: 161 aa. Probable conserved ala-rich transmembrane protein, equivalent to Q49991|ML1027|U1764I possible membrane protein from Mycobacterium leprae (157 aa), FASTA score [...]
Rv2699c protein networkhttps://string-db.org/network/83332.Rv2699cRv2699c, (MTCY05A6.20c), len: 100 aa. Conserved hypothetical protein, very equivalent to Q49990|ML1026|U1764J hypothetical protein from Mycobacterium leprae (100 aa), FASTA scores: opt: 632, E(): [...]
Rv2700 protein networkhttps://string-db.org/network/83332.Rv2700Rv2700, (MTCY05A6.21), len: 216 aa. Possible secreted ala-rich protein, equivalent to Q4998|ML1025|U1764H possible secreted protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1198,E() [...]
suhB protein networkhttps://string-db.org/network/83332.Rv2701cInositol-1-monophosphatase SuhB; Catalyzes the dephosphorylation of inositol 1-phosphate (I-1- P) to yield free myo-inositol, a key metabolite in mycobacteria. Is also able to hydrolyze a variety [...]
ppgK protein networkhttps://string-db.org/network/83332.Rv2702Polyphosphate glucokinase PpgK (polyphosphate-glucose phosphotransferase); Catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than [...]
sigA protein networkhttps://string-db.org/network/83332.Rv2703RNA polymerase sigma factor SigA (sigma-A); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma facto [...]
Rv2704 protein networkhttps://string-db.org/network/83332.Rv2704Conserved protein; Rv2704, (MTCY05A6.25), len: 142 aa. Conserved protein, highly similar (but shorter 25 aa) to Q9RYB7|DR0033 conserved hypothetical protein from Deinococcus radiodurans (157 aa), [...]
Rv2705c protein networkhttps://string-db.org/network/83332.Rv2705cConserved hypothetical protein; Rv2705c, (MTCY05A6.26c), len: 129 aa (unlikely ORF). Conserved hypothetical protein, similar to others e.g. Q9RXR5|DR0242 conserved hypothetical protein from Deino [...]
Rv2706c protein networkhttps://string-db.org/network/83332.Rv2706cHypothetical protein; Rv2706c, (MTCY05A6.27c), len: 85 aa (unlikely ORF). Hypothetical unknown protein.
Rv2707 protein networkhttps://string-db.org/network/83332.Rv2707Rv2707, (MTCY05A6.28), len: 324 aa. Probable conserved transmembrane ala-, leu-rich protein, equivalent to Q49985|ML1017|U1764D possible conserved integral membrane protein from Mycobacterium lep [...]
Rv2708c protein networkhttps://string-db.org/network/83332.Rv2708cRv2708c, (MTCY05A6.29), len: 82 aa. Conserved hypothetical protein, equivalent (but shorter 25 aa) to Q49984|ML1016|U1764C hypothetical protein from Mycobacterium leprae (107 aa), FASTA scores: o [...]
Rv2709 protein networkhttps://string-db.org/network/83332.Rv2709Rv2709, (MTCY05A6.30), len: 148 aa. Probable conserved transmembrane protein, equivalent to Q9CCB4|ML1015 (alias Q49983|U1764B but extended in N-terminus) possible conserved membrane protein from [...]
sigB protein networkhttps://string-db.org/network/83332.Rv2710RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. A non-essential principal [...]
ideR protein networkhttps://string-db.org/network/83332.Rv2711Iron-dependent repressor and activator IdeR; Metal-dependent DNA-binding protein that controls transcription of many genes involved in iron metabolism. Acts as a repressor of siderophore biosynth [...]
Rv2712c protein networkhttps://string-db.org/network/83332.Rv2712cHypothetical protein; Rv2712c, (MTCY05A6.33c), len: 352 aa. Hypothetical unknown ala-, leu-rich protein.
sthA protein networkhttps://string-db.org/network/83332.Rv2713Probable soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belon [...]
Rv2714 protein networkhttps://string-db.org/network/83332.Rv2714Rv2714, (MTCY05A6.35), len: 324 aa. Conserved ala-,leu-rich protein, equivalent to Q49847|ML1009|B2235_F1_6 hypothetical protein from Mycobacterium leprae (326 aa),FASTA scores: opt: 1881, E(): 5 [...]
Rv2715 protein networkhttps://string-db.org/network/83332.Rv2715Possible hydrolase; Rv2715, (MTCY05A6.36), len: 341 aa. Possible hydrolase, showing some similarity with other hydrolases e.g. Q9I5B0|PA0829 probable hydrolase from Pseudomonas aeruginosa (313 aa [...]
Rv2716 protein networkhttps://string-db.org/network/83332.Rv2716Conserved protein; Rv2716, (MTCY05A6.37), len: 228 aa. Conserved protein, similar to other proteins e.g. Q9RKR0|SCC75A.14 hypothetical 23.3 KDA protein from Streptomyces coelicolor (214 aa), FAST [...]
Rv2717c protein networkhttps://string-db.org/network/83332.Rv2717cConserved protein; May play a role in the intracellular transport of hydrophobic ligands.
nrdR protein networkhttps://string-db.org/network/83332.Rv2718cProbable transcriptional regulatory protein NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR fam [...]
chiZ protein networkhttps://string-db.org/network/83332.Rv2719cPossible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of na [...]
lexA protein networkhttps://string-db.org/network/83332.Rv2720Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the 14 bp palindromic sequence 5'-CGAACNNNNGT [...]
Rv2721c protein networkhttps://string-db.org/network/83332.Rv2721cRv2721c, (MTCY05A6.42c, MTCY154.01c), len: 699 aa. Possible conserved transmembrane ala-, gly-rich protein,equivalent to Q49837|ML1002|U2235I possible conserved membrane protein from Mycobacteriu [...]
Rv2722 protein networkhttps://string-db.org/network/83332.Rv2722Rv2722, (MTCY154.02), len: 82 aa. Conserved hypothetical protein, similar to Q9CCB9|ML1001 hypothetical protein from Mycobacterium leprae (91 aa), FASTA scores: opt: 154, E(): 0.00053, (37.5% ide [...]
Rv2723 protein networkhttps://string-db.org/network/83332.Rv2723Rv2723, (MTCY154.03), len: 397 aa. Probable conserved integral membrane protein, highly similar to others e.g. Q9Z503|SCC54.23c putative integral membrane export protein from Streptomyces coelico [...]
fadE20 protein networkhttps://string-db.org/network/83332.Rv2724cRv2724c, (MTCY154.04c), len: 386 aa. Probable fadE20, acyl-CoA dehydrogenase, highly similar to many e.g. Q9X7Y2|SC6A5.36 from Streptomyces coelicolor (382 aa),FASTA scores: opt: 1583, E(): 6.9e- [...]
hflX protein networkhttps://string-db.org/network/83332.Rv2725cProbable GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX- [...]
dapF protein networkhttps://string-db.org/network/83332.Rv2726cProbable diaminopimelate epimerase DapF (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine a [...]
miaA protein networkhttps://string-db.org/network/83332.Rv2727ctRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(di [...]
Rv2728c protein networkhttps://string-db.org/network/83332.Rv2728cRv2728c, (MTCY154.08c), len: 231 aa. Conserved ala-rich protein, equivalent to Q49835|ML0994|B2235_C1_162 hypothetical protein from Mycobacterium leprae (232 aa),FASTA scores: opt: 1037, E(): 1.2 [...]
Rv2729c protein networkhttps://string-db.org/network/83332.Rv2729cRv2729c, (MTCY154.09c), len: 301 aa. Probable conserved integral membrane ala-, val-, leu-rich protein,similar to P42459|YLEU_CORGL hypothetical 29.6 KDA protein from Corynebacterium glutamicum ( [...]
Rv2730 protein networkhttps://string-db.org/network/83332.Rv2730Hypothetical protein; Rv2730, (MTCY174.10), len: 158 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv2731 protein networkhttps://string-db.org/network/83332.Rv2731Rv2731, (MTCY174.11), len: 450 aa. Conserved ala-,arg-rich protein, highly similar in part to Q49849|B2235_F2_77 hypothetical protein from Mycobacterium leprae (266 aa), FASTA scores: opt: 368, E [...]
Rv2732c protein networkhttps://string-db.org/network/83332.Rv2732cRv2732c, (MTCY174.12c), len: 204 aa. Probable conserved transmembrane protein, similar to Q49834 hypothetical protein B2235_C1_155 from Mycobacterium leprae (209 aa), FASTA scores: opt: 932, E(): [...]
miaB protein networkhttps://string-db.org/network/83332.Rv2733cConserved hypothetical alanine, arginine-rich protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine [...]
Rv2734 protein networkhttps://string-db.org/network/83332.Rv2734Rv2734, (MTCY154.14), len: 284 aa. Conserved hypothetical protein, highly similar to various proteins e.g. Q984J2|MLR7981 ABC transporter ATP-binding protein from Rhizobium loti (Mesorhizobium lo [...]
Rv2735c protein networkhttps://string-db.org/network/83332.Rv2735cRv2735c, (MTCY154.15c), len: 330 aa. Conserved hypothetical protein, showing some similarity with Q98DH2|MLR4706 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (302 aa), FASTA scor [...]
recX protein networkhttps://string-db.org/network/83332.Rv2736cRegulatory protein RecX; Binds to RecA inhibiting ATP hydrolysis and the generation of heteroduplex DNA. It might act as an anti-recombinase to quell inappropriate recombinational repair during n [...]
Rv2737A protein networkhttps://string-db.org/network/83332.Rv2737ARv2737A, len: 57 aa. Conserved hypothetical cys-rich protein (possibly gene fragment), similar to central part of AJ243803_1|glgA from Streptomyces coelicolor glgA (181 aa), FASTA scores: opt: 21 [...]
recA protein networkhttps://string-db.org/network/83332.Rv2737cRecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-str [...]
Rv2738c protein networkhttps://string-db.org/network/83332.Rv2738cRv2738c, (MTV002.03c), len: 68 aa. Conserved hypothetical protein, equivalent to Q9CCC1|ML0986 hypothetical protein from Mycobacterium leprae (67 aa),FASTA scores: opt: 397, E(): 3.7e-22, (83.6% [...]
Rv2739c protein networkhttps://string-db.org/network/83332.Rv2739cRv2739c, (MTV002.04c), len: 388 aa. Possible ala-rich transferase, equivalent to Q49841|ML0985|MLCB33.02c|U2235C possible glycosyltransferase from Mycobacterium leprae (392 aa),FASTA scores: opt: [...]
ephG protein networkhttps://string-db.org/network/83332.Rv2740Epoxide hydrolase; Epoxide hydrolase capable of hydrolyzing long or bulky lipophilic epoxides such as 9,10-epoxystearic acid and cholesterol 5,6- oxide in vitro. The physiological substrates have [...]
PE_PGRS47 protein networkhttps://string-db.org/network/83332.Rv2741PE-PGRS family protein PE_PGRS47; Contributes to evasion of both innate and adaptive immunity. Inhibits autophagy in infected host phagocytes and inhibits major histocompatibility complex (MHC) c [...]
Rv2742c protein networkhttps://string-db.org/network/83332.Rv2742cRv2742c, (MTV002.07c), len: 277 aa (questionable ORF). Conserved hypothetical arg-rich protein. Extreme N-terminus is highly similar to the N-teminus of Q9CCC1ML0986 hypothetical protein from Myc [...]
Rv2743c protein networkhttps://string-db.org/network/83332.Rv2743cRv2743c, (MTV002.08c), len: 270 aa. Possible conserved transmembrane ala-rich protein, equivalent to Q49833|MLCB33.04c|B2235_C1_148 unknown protein from Mycobacterium leprae (123 aa), FASTA score [...]
35kd_ag protein networkhttps://string-db.org/network/83332.Rv2744cRv2744c, (MTV002.09c), len: 270 aa. 35kd_ag,conserved ala-rich protein 35-kd antigen (see O'Connor et al., 1990). N-terminal part is equivalent to Q49840|MLCB33.06c|B2235_C2_187 hypothetical prot [...]
clgR protein networkhttps://string-db.org/network/83332.Rv2745cTranscriptional regulatory protein ClgR; Overexpression leads to expression of the clp regulon (ClpP1, ClpP2 and ClpC1).
pgsA3 protein networkhttps://string-db.org/network/83332.Rv2746cProbable phosphatidylglycerophosphate synthase; Probably catalyzes the synthesis of phosphatidylglycerophosphate by transferring a phosphatidyl group from CDP-diacylglycerol to glycerol 3-phospha [...]
argA protein networkhttps://string-db.org/network/83332.Rv2747Probable L-glutamate alpha-N-acetyltranferase ArgA (alpha-N-acetylglutamate synthase); Catalyzes the conversion of L-glutamate to alpha-N-acetyl-L- glutamate. L-glutamine is a significantly bette [...]
ftsK protein networkhttps://string-db.org/network/83332.Rv2748cPossible cell division transmembrane protein FtsK; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-di [...]
Rv2749 protein networkhttps://string-db.org/network/83332.Rv2749Conserved protein; Rv2749, (MTV002.14), len: 104 aa. Conserved protein,showing some similarity with Q9I1R9|PA2198 hypothetical protein from Pseudomonas aeruginosa (114 aa), FASTA scores: opt: 157 [...]
Rv2750 protein networkhttps://string-db.org/network/83332.Rv2750Rv2750, (MTV002.15), len: 272 aa. Probable dehydrogenase, highly similar to other dehydrogenases/reductases e.g. Q9L5X5|cox cholesterol oxidase from Nocardioides simplex (Arthrobacter simplex) (2 [...]
Rv2751 protein networkhttps://string-db.org/network/83332.Rv2751Conserved protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
rnj protein networkhttps://string-db.org/network/83332.Rv2752cConserved hypothetical protein; An RNase that has 5'-3' exonuclease and possible endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By [...]
dapA protein networkhttps://string-db.org/network/83332.Rv2753cProbable dihydrodipicolinate synthase DapA (DHDPS) (dihydrodipicolinate synthetase); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodi [...]
thyX protein networkhttps://string-db.org/network/83332.Rv2754cProbable thymidylate synthase ThyX (ts) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10- [...]
hsdS.1 protein networkhttps://string-db.org/network/83332.Rv2755cRv2755c, (MTV002.20c), len: 91 aa. Possible hsdS.1,fragment of type I restriction/modification system specificity determinant (S protein), similar to the N-terminus of other hsdS proteins e.g. O3 [...]
hsdM protein networkhttps://string-db.org/network/83332.Rv2756cRv2756c, (MTV002.21c), len: 540 aa. Possible hsdM,type I restriction/modification system DNA methylase (M protein), highly similar to others e.g. Q9P9X8|XF2742 from Xylella fastidiosa (519 aa), F [...]
vapC21 protein networkhttps://string-db.org/network/83332.Rv2757cPossible toxin VapC21; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralize [...]
vapB21 protein networkhttps://string-db.org/network/83332.Rv2758cPossible antitoxin VapB21; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC21.
vapC42 protein networkhttps://string-db.org/network/83332.Rv2759cPossible toxin VapC42. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB42 (By similarity). Belongs to the PINc/VapC protein f [...]
vapB42 protein networkhttps://string-db.org/network/83332.Rv2760cPossible antitoxin VapB42; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC42.
hsdS protein networkhttps://string-db.org/network/83332.Rv2761cRv2761c, (MTV002.26c), len: 364 aa. Possible hsdS,type I restriction/modification system specificity determinant (S protein), similar in part to other hsdS protein (S proteins) e.g. Q9P9X9|XF2741 [...]
Rv2762c protein networkhttps://string-db.org/network/83332.Rv2762cRv2762c, (MTV002.27c), len: 139 aa. Conserved hypothetical protein, similar to C-terminus of hypothetical proteins: Q9A380|CC3324 from Caulobacter crescentus (409 aa), FASTA scores: opt: 181, E() [...]
dfrA protein networkhttps://string-db.org/network/83332.Rv2763cDihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase); Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precur [...]
thyA protein networkhttps://string-db.org/network/83332.Rv2764cProbable thymidylate synthase ThyA (ts) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10- [...]
Rv2765 protein networkhttps://string-db.org/network/83332.Rv2765Rv2765, (MTV002.30), len: 245 aa. Probable ala-rich hydrolase, similar to various hydrolases or hypothetical proteins e.g. Q9KYM6|SC9H11.13c putative hydrolase from Streptomyces coelicolor (251 a [...]
Rv2766c protein networkhttps://string-db.org/network/83332.Rv2766cRv2766c, (MTV002.31c), len: 260 aa. Probable short-chain dehydrogenase/reductase, similar to others (from bacteria and eukaryota) e.g. Q9K3Y8|2SCG61.27c putative short chain oxidoreductase from S [...]
Rv2767c protein networkhttps://string-db.org/network/83332.Rv2767cPossible membrane protein; Rv2767c, (MTV002.32c), len: 117 aa (questionable ORF). Possible membrane protein, showing very weak similarity with Q9L2H7|SCC121.09 putative metal transport ABC transp [...]
PPE43 protein networkhttps://string-db.org/network/83332.Rv2768cRv2768c, (MTV002.33c), len: 394 aa. PPE43, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. upstream ORF O33312|Rv2770c|MTV002.35c (402 aa), FASTA scores: opt: 113 [...]
PE27 protein networkhttps://string-db.org/network/83332.Rv2769cRv2769c, (MTV002.34c), len: 275 aa. PE27, Member of the Mycobacterium tuberculosis PE family (see citation below), highly similar to many (notably in N-terminal part) e.g. P96361|Rv1040c|MTCY10G2 [...]
PPE44 protein networkhttps://string-db.org/network/83332.Rv2770cRv2770c, (MTV002.35c), len: 382 aa. PPE44, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa), [...]
Rv2771c protein networkhttps://string-db.org/network/83332.Rv2771cRv2771c, (MTV002.36c), len: 150 aa. Conserved hypothetical protein, equivalent to Q9CBV8|ML1525 hypothetical protein from Mycobacterium leprae (151 aa),FASTA scores: opt: 489, E(): 1.7e-27, (52.7 [...]
Rv2772c protein networkhttps://string-db.org/network/83332.Rv2772cRv2772c, (MTV002.37c), len: 157 aa. Probable conserved transmembrane protein, equivalent to Q9CBV7|ML1526 conserved membrane protein from Mycobacterium leprae (160 aa), FASTA scores: opt: 767, E( [...]
dapB protein networkhttps://string-db.org/network/83332.Rv2773cDihydrodipicolinate reductase DapB (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, wi [...]
Rv2774c protein networkhttps://string-db.org/network/83332.Rv2774cHypothetical protein; Rv2774c, (MTV002.39c), len: 134 aa. Hypothetical unknown protein.
Rv2775 protein networkhttps://string-db.org/network/83332.Rv2775GCN5-related N-acetyltransferase; Rv2775, (MTV002.40), len: 153 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Showing weak simi [...]
Rv2776c protein networkhttps://string-db.org/network/83332.Rv2776cRv2776c, (MTV002.41c), len: 309 aa. Probable oxidoreductase, similar to other oxidoreductases e.g. Q9KZ15|SC10B7.17 putative iron-sulfur oxidoreductase from Streptomyces coelicolor (364 aa), FAST [...]
Rv2777c protein networkhttps://string-db.org/network/83332.Rv2777cRv2777c, (MTV002.42c), len: 356 aa. Conserved hypothetical protein, highly similar (but longer in N-terminus) to hypothetical proteins Q9KZ16|SC10B7.16 from Streptomyces coelicolor (296 aa), FAST [...]
Rv2778c protein networkhttps://string-db.org/network/83332.Rv2778cConserved protein; Rv2778c, (MTV002.43c), len: 156 aa. Conserved protein, similar to Q9CBF7|ML2031 hypothetical protein from Mycobacterium leprae (151 aa), FASTA scores: opt: 227, E(): 8.5e-09, ( [...]
Rv2779c protein networkhttps://string-db.org/network/83332.Rv2779cPossible transcriptional regulatory protein (probably Lrp/AsnC-family); Rv2779c, (MTV002.44c), len: 179 aa. Possible transcriptional regulator, from the Lrp/AsnC family,similar (but longer ~30 aa [...]
ald protein networkhttps://string-db.org/network/83332.Rv2780Secreted L-alanine dehydrogenase Ald (40 kDa antigen) (TB43); Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis [...]
Rv2781c protein networkhttps://string-db.org/network/83332.Rv2781cRv2781c, (MTV002.46c), len: 344 aa. Possible ala-rich oxidoreductase, similar to various oxidoreductases or hypothetical proteins e.g. Q9RDD8|SCC77.20c putative oxidoreductase from Streptomyces c [...]
pepR protein networkhttps://string-db.org/network/83332.Rv2782cRv2782c, (MTV002.47c), len: 438 aa. Probable pepR,protease/peptidase, equivalent to O32965|YR82_MYCLE|ML0855|MLCB22.26c hypothetical zinc protease from Mycobacterium leprae (445 aa), FASTA scores [...]
gpsI protein networkhttps://string-db.org/network/83332.Rv2783cPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
lppU protein networkhttps://string-db.org/network/83332.Rv2784cRv2784c, (MTV002.49c), len: 171 aa. Probable lppU,lipoprotein, sharing no homology with other proteins. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprot [...]
rpsO protein networkhttps://string-db.org/network/83332.Rv2785c30S ribosomal protein S15 RpsO; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging [...]
ribF protein networkhttps://string-db.org/network/83332.Rv2786cRiboflavin biosynthesis protein; Rv2786c, (MTV002.51c), len: 331 aa. Probable ribF,FAD synthetase/riboflavin biosynthesis protein,bifunctional enzyme, equivalent to O32968|RIBF|ML0852 riboflavin [...]
Rv2787 protein networkhttps://string-db.org/network/83332.Rv2787Rv2787, (MTV002.52), len: 587 aa. Conserved hypothetical ala-rich protein, equivalent to Q9CCI1|ML0798 hypothetical protein from Mycobacterium leprae (592 aa),FASTA scores: opt: 2994, E(): 6.9e-1 [...]
sirR protein networkhttps://string-db.org/network/83332.Rv2788Rv2788, (MTV002.53), len: 228 aa. Probable sirR,transcriptional repressor, highly similar to others e.g. Q9RRF3|DR2539 putative iron dependent repressor from Deinococcus radiodurans (232 aa), FAS [...]
fadE21 protein networkhttps://string-db.org/network/83332.Rv2789cRv2789c, (MTV002.54c), len: 410 aa. Probable fadE21,acyl-CoA dehydrogenase, similar to many e.g. P45857|ACDB_BACSU|MMGC from Bacillus subtilis (379 aa),FASTA scores: opt: 689, E(): 9.3e-37, (35.7 [...]
ltp1 protein networkhttps://string-db.org/network/83332.Rv2790cRv2790c, (MTV002.55c), len: 401 aa. Probable ltp1,lipid-transfer protein, highly similar to many eukaryotic sterol-carrier proteins/lipid-transfer protein precursors (see Ossendorp & Wirtz 1993) [...]
Rv2791c protein networkhttps://string-db.org/network/83332.Rv2791cProbable transposase; Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), [...]
Rv2792c protein networkhttps://string-db.org/network/83332.Rv2792cPossible resolvase; Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible resolvase (202 a [...]
truB protein networkhttps://string-db.org/network/83332.Rv2793ctRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
pptT protein networkhttps://string-db.org/network/83332.Rv2794cRv2794c, (MTV002.59c), len: 227 aa. PptT,phosphopantetheinyl transferase, equivalent to Q9Z5I5|ML1547|MLCB596.23 putative iron-chelating complex subunit from Mycobacterium leprae (227 aa), FASTA [...]
Rv2795c protein networkhttps://string-db.org/network/83332.Rv2795cRv2795c, (MTV002.60c), len: 324 aa. Conserved hypothetical protein, equivalent to Q9Z5I6|ML1548|MLCB596.22 hypothetical 37.5 KDA protein from Mycobacterium leprae (321 aa), FASTA scores: opt: 201 [...]
lppV protein networkhttps://string-db.org/network/83332.Rv2796cRv2796c, (MTV002.61c, MTCY16B7.47), len: 187 aa. Probable lppV, conserved lipoprotein, similar to others from Mycobacterium tuberculosis e.g. P95009|LPPB|Rv2544|MTCY159.12c probable conserved lip [...]
Rv2797c protein networkhttps://string-db.org/network/83332.Rv2797cRv2797c, (MTCY16B7.46), len: 562 aa. Conserved hypothetical ala-rich protein. C-terminus highly similar to several mycobacterial proteins e.g. AAK46927|MT2616 hypothetical 28.0 KDA protein from M [...]
Rv2798c protein networkhttps://string-db.org/network/83332.Rv2798cRv2798c, (MTCY16B7.45), len: 108 aa. Conserved hypothetical ala-rich protein, similar to P71545|Y965_MYCTU|Rv0965c|MT0993|MTCY10D7.09 hypothetical 14.5 KDA protein from Mycobacterium tuberculosis [...]
Rv2799 protein networkhttps://string-db.org/network/83332.Rv2799Probable membrane protein; Rv2799, (MTCY16B7.44c), len: 209 aa. Probable membrane protein. Predicted to be an outer membrane protein (See Song et al., 2008).
Rv2800 protein networkhttps://string-db.org/network/83332.Rv2800Possible hydrolase; Rv2800, (MTCY16B7.43c), len: 549 aa. Possible hydrolase, an esterase or an acylase. Similar, but longer in N-terminus, to esterases or acylases e.g. Q9L9D7|COCE cocaine estera [...]
mazE9 protein networkhttps://string-db.org/network/83332.Rv2801APossible antitoxin MazE9; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis neutralizes the effect of cognate toxin MazF9.
mazF9 protein networkhttps://string-db.org/network/83332.Rv2801cToxin MazF9; Toxic component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coex [...]
Rv2802c protein networkhttps://string-db.org/network/83332.Rv2802cRv2802c, (MTCY16B7.41), len: 347 aa. Hypothetical unknown arg-, ala-rich protein. C-terminus shows some similarity with N-terminal part of hypothetical proteins Q98K84|MLR1592 from Rhizobium loti [...]
Rv2803 protein networkhttps://string-db.org/network/83332.Rv2803Rv2803, len: 155 aa. Conserved hypothetical protein,similar to hypothetical proteins from other organisms, and with some similarity to C-terminal part of Rv0918|Z95210_12 hypothetical protein fro [...]
Rv2804c protein networkhttps://string-db.org/network/83332.Rv2804cHypothetical protein; Rv2804c, (MTCY16B7.39), len: 209 aa. Hypothetical unknown protein, overlaps neighbouring orf Rv2805|MTCY16B7.38c. This region is a possible MT-complex-specific genomic islan [...]
Rv2805 protein networkhttps://string-db.org/network/83332.Rv2805Rv2805, (MTCY16B7.38c), len: 134 aa. Conserved hypothetical protein, highly similar to N-terminal region of downstream ORF P71644|Rv2807|MTCY16B7.36c conserved hypothetical protein from Mycobacte [...]
Rv2806 protein networkhttps://string-db.org/network/83332.Rv2806Possible membrane protein; Rv2806, (MTCY16B7.37c), len: 63 aa. Possible membrane protein, sharing no homology. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007) [...]
Rv2807 protein networkhttps://string-db.org/network/83332.Rv2807Rv2807, (MTCY16B7.36c), len: 384 aa. Conserved hypothetical protein, highly similar, but shorter 35 aa, to Q9KK74 hypothetical 47.4 KDA protein from Brevibacterium linens (418 aa), FASTA scores: [...]
Rv2808 protein networkhttps://string-db.org/network/83332.Rv2808Hypothetical protein; Rv2808, (MTCY16B7.35c), len: 85 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv2809 protein networkhttps://string-db.org/network/83332.Rv2809Hypothetical protein; Rv2809, (MTCY16B7.34c), len: 103 aa (questionable ORF). Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv2810c protein networkhttps://string-db.org/network/83332.Rv2810cProbable transposase; Rv2810c, (MTCY16B7.33), len: 133 aa. Probable transposase for IS1555, similar to C-terminal domain of transposases for defective IS1555 e.g. Q9LCS0|TNPA transposase from Art [...]
Rv2811 protein networkhttps://string-db.org/network/83332.Rv2811Rv2811, (MTCY16B7.32c), len: 202 aa. Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 hypothetical 17.7 KDA protein Mycobacterium tuberculosis strain CDC1551 [...]
Rv2812 protein networkhttps://string-db.org/network/83332.Rv2812Probable transposase; Rv2812, (MTCY16B7.31c), len: 469 aa. Probable transposase for IS1604, similar to putative transposases and hypothetical proteins e.g. Q9EZM2|putative transposase from Mycoba [...]
Rv2813 protein networkhttps://string-db.org/network/83332.Rv2813Rv2813, (MTCY16B7.30c), len: 270 aa. Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 hypothetical 30.4 KDA protein from Bacillus stearothermoph [...]
Rv2814c protein networkhttps://string-db.org/network/83332.Rv2814cProbable transposase; Rv2814c, (MTCY16B7.29), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described [...]
Rv2815c protein networkhttps://string-db.org/network/83332.Rv2815cProbable transposase; Rv2815c, (MTCY16B7.28), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase describ [...]
cas2 protein networkhttps://string-db.org/network/83332.Rv2816cConserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, t [...]
cas1 protein networkhttps://string-db.org/network/83332.Rv2817cConserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, t [...]
csm6 protein networkhttps://string-db.org/network/83332.Rv2818cHypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposabl [...]
csm5 protein networkhttps://string-db.org/network/83332.Rv2819cHypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposabl [...]
csm4 protein networkhttps://string-db.org/network/83332.Rv2820cHypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposabl [...]
csm3 protein networkhttps://string-db.org/network/83332.Rv2821cConserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, t [...]
csm2 protein networkhttps://string-db.org/network/83332.Rv2822cHypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposabl [...]
cas10 protein networkhttps://string-db.org/network/83332.Rv2823cConserved protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable e [...]
cas6 protein networkhttps://string-db.org/network/83332.Rv2824cHypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposabl [...]
Rv2825c protein networkhttps://string-db.org/network/83332.Rv2825cRv2825c, (MTCY16B7.17), len: 215 aa. Conserved hypothetical protein, similar to Q9RY53|DR0097 conserved hypothetical protein from Deinococcus radiodurans (189 aa),FASTA scores: opt: 261, E(): 8e- [...]
Rv2826c protein networkhttps://string-db.org/network/83332.Rv2826cHypothetical protein; Rv2826c, (MTCY16B7.16), len: 294 aa. Hypothetical unknown protein.
Rv2827c protein networkhttps://string-db.org/network/83332.Rv2827cHypothetical protein; Rv2827c, (MTCY16B7.15), len: 295 aa. Hypothetical unknown protein, equivalent to AAK47219 from Mycobacterium tuberculosis strain CDC1551 (315 aa) but shorter 20 aa.
Rv2828A protein networkhttps://string-db.org/network/83332.Rv2828ARv2828A, len: 89 aa. Conserved hypothetical protein,present in many mycobacteria. Equivalent to BCG2848c and Mb2852A (100% identity to both in 89 aa overlap).
Rv2828c protein networkhttps://string-db.org/network/83332.Rv2828cRv2828c, (MTCY16B7.14), len: 181 aa. Conserved hypothetical protein, similar to Q9RY53|DR0097 conserved hypothetical protein from Deinococcus radiodurans (189 aa),FASTA scores: opt: 267, E(): 1.9 [...]
vapC22 protein networkhttps://string-db.org/network/83332.Rv2829cPossible toxin VapC22; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony formation. Its toxic effe [...]
vapB22 protein networkhttps://string-db.org/network/83332.Rv2830cPossible antitoxin VapB22; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC22.
echA16 protein networkhttps://string-db.org/network/83332.Rv2831Probable enoyl-CoA hydratase EchA16 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv2831, (MTCY16B7.11c), len: 249 aa. Probable echA16, enoyl-CoA hydratase, similar to others e.g. [...]
ugpC protein networkhttps://string-db.org/network/83332.Rv2832cRv2832c, (MTCY16B7.10), len: 360 aa. Probable ugpC,Sn-glycerol-3-phosphate transport ATP-binding protein ABC transporter (see Braibant et al., 2000), similar to others: CAC48805 probable glycerol [...]
ugpB protein networkhttps://string-db.org/network/83332.Rv2833cRv2833c, (MTCY16B7.09), len: 436 aa. Probable ugpB,Sn-glycerol-3-phosphate binding lipoprotein component of Sn-glycerol-3-phosphate transport system (see citation below), similar to various trans [...]
ugpE protein networkhttps://string-db.org/network/83332.Rv2834cRv2834c, (MTCY16B7.08), len: 275 aa. Probable ugpE,Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9KDY3|BH107 [...]
ugpA protein networkhttps://string-db.org/network/83332.Rv2835cRv2835c, (MTCY1B7.07), len: 303 aa. Probable ugpA,Sn-glycerol-3-phosphate transport integral membrane protein ABC transporter (see citation below), similar to various permeases e.g. Q9RK71|SCF11. [...]
dinF protein networkhttps://string-db.org/network/83332.Rv2836cRv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 [...]
nrnA protein networkhttps://string-db.org/network/83332.Rv2837cConserved protein; Bifunctional enzyme which has both oligoribonuclease and pAp- phosphatase activities. Degrades RNA oligonucleotides with a length of 5 nucleotides and shorter, with a preferenc [...]
rbfA protein networkhttps://string-db.org/network/83332.Rv2838cProbable ribosome-binding factor a RbfA (P15B protein); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free [...]
infB protein networkhttps://string-db.org/network/83332.Rv2839cProbable translation initiation factor if-2 InfB; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes i [...]
Rv2840c protein networkhttps://string-db.org/network/83332.Rv2840cRv2840c, (MTCY16B7.02), len: 99 aa. Conserved hypothetical protein, equivalent to Q9Z5J0|ML1557|MLCB596.13 hypothetical 11.6 KDA protein from Mycobacterium leprae (106 aa), FASTA scores: opt: 501 [...]
nusA protein networkhttps://string-db.org/network/83332.Rv2841cProbable N utilization substance protein A NusA; Participates in both transcription termination and antitermination; Belongs to the NusA family.
rimP protein networkhttps://string-db.org/network/83332.Rv2842cConserved protein; Required for maturation of 30S ribosomal subunits.
Rv2843 protein networkhttps://string-db.org/network/83332.Rv2843Rv2843, (MTCY24A1.14c), len: 181 aa. Probable conserved transmembrane ala-rich protein, equivalent to Q9Z5J3|ML1560|MLCB596.10c hypothetical 17.5 KDA protein from Mycobacterium leprae (178 aa), F [...]
Rv2844 protein networkhttps://string-db.org/network/83332.Rv2844Rv2844, (MTCY24A1.13c), len: 162 aa. Conserved ala-rich protein, equivalent to Q9Z5J4|ML1561|MLCB596.09c hypothetical 17.5 KDA protein from Mycobacterium leprae (165 aa), FASTA scores: opt: 771, [...]
proS protein networkhttps://string-db.org/network/83332.Rv2845cProline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA( [...]
efpA protein networkhttps://string-db.org/network/83332.Rv2846cRv2846c, (MTCY24A1.11), len: 530 aa. Possible efpA,integral membrane efflux protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug (see citations below), eq [...]
cysG protein networkhttps://string-db.org/network/83332.Rv2847cRv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-III c-methyltransferase, precorrin-2 oxidase and ferrochelatase. C-terminus hi [...]
cobB protein networkhttps://string-db.org/network/83332.Rv2848cProbable cobyrinic acid A,C-diamide synthase CobB; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammo [...]
cobO protein networkhttps://string-db.org/network/83332.Rv2849cRv2849c, (MTCY24A1.08), len: 207 aa. Probable cobO,cob(I)alamin adenosyltransferase, highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64 [...]
Rv2850c protein networkhttps://string-db.org/network/83332.Rv2850cRv2850c, (MTCY24A1.07), len: 629 aa. Possible magnesium-chelatase, highly similar (but with gaps) to magnesium-chelatases from notably photosynthetic organisms involved in chlorophyll biosynthesi [...]
Rv2851c protein networkhttps://string-db.org/network/83332.Rv2851cGCN5-related N-acetyltransferase; Rv2851c, (MTCY24A1.06), len: 156 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain. See Vetting et al. 2005. Similar to oth [...]
mqo protein networkhttps://string-db.org/network/83332.Rv2852cRv2852c, (MT2918, MTCY24A1.05), len: 493 aa. Probable mqo, malate:quinone oxidoreductase, highly similar to others e.g. O69282|MQO_CORGL from Corynebacterium glutamicum (Brevibacterium flavum) (4 [...]
PE_PGRS48 protein networkhttps://string-db.org/network/83332.Rv2853PE-PGRS family protein PE_PGRS48; Rv2853, (MTCY24A1.04c), len: 615 aa. PE_PGRS48,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), high [...]
Rv2854 protein networkhttps://string-db.org/network/83332.Rv2854Unknown protein; Rv2854, (MTCY24A1.03c), len: 346 aa. Unknown protein, showing similarity with Q9CD03|ML2603 hypothetical protein from Mycobacterium leprae (279 aa), FASTA scores: opt: 154, E(): [...]
mtr protein networkhttps://string-db.org/network/83332.Rv2855NADPH-dependent mycothiol reductase Mtr; Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol. Belongs to the class-I pyridine nucleotid [...]
nicT protein networkhttps://string-db.org/network/83332.Rv2856Rv2856, (MTCY24A1.01c), len: 372 aa. Possible nicT,nickel-transport integral membrane protein, similar to transport proteins and hydrogenase cluster proteins e.g. BAB58860|SAV2698 hypothetical 37 [...]
Rv2857c protein networkhttps://string-db.org/network/83332.Rv2857cRv2857c, (MTV003.03c), len: 258 aa. Probable short-chain dehydrogenase/reductase, highly similar to various dehydrogenases e.g. O88068|SCI35.33c probable dehydrogenase (SDR family) from Streptomy [...]
aldC protein networkhttps://string-db.org/network/83332.Rv2858cRv2858c, (MTV003.04c), len: 455 aa. Probable aldC,aldehyde dehydrogenase, similar to many e.g. O88069|SCI35.34c putative aldehyde dehydrogenase from Streptomyces coelicolor (483 aa), FASTA scores [...]
Rv2859c protein networkhttps://string-db.org/network/83332.Rv2859cRv2859c, (MTV003.05c), len: 308 aa. Possible amidotransferase, equivalent (but longer 58 aa) to Q9CBU9|ML1573 possible amidotransferase from Mycobacterium leprae (249 aa), FASTA scores: opt: 1226 [...]
glnA4 protein networkhttps://string-db.org/network/83332.Rv2860cRv2860c, (MTV003.06c), len: 457 aa. Probable glnA4,glutamine synthetase class II, similar to many glutamine synthases e.g. O88070|SCI35.35c from Streptomyces coelicolor (462 aa), FASTA scores: op [...]
mapB protein networkhttps://string-db.org/network/83332.Rv2861cMethionine aminopeptidase MapB (map) (peptidase M); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequ [...]
vapB23 protein networkhttps://string-db.org/network/83332.Rv2862APossible antitoxin VapB23; Putative antitoxin component of a possible type II toxin- antitoxin (TA) system. The cognate toxin is VapC23.
Rv2862c protein networkhttps://string-db.org/network/83332.Rv2862cRv2862c, (MTV003.08), len: 194 aa. Conserved hypothetical protein, showing some similarity with others e.g. Q9X8X5|SCH35.31c hypothetical 19.6 KDA protein from Streptomyces coelicolor (180 aa), F [...]
vapC23 protein networkhttps://string-db.org/network/83332.Rv2863Possible toxin VapC23; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB23 (By similarity). Belongs to the PINc/VapC protein family.
Rv2864c protein networkhttps://string-db.org/network/83332.Rv2864cRv2864c, (MTV003.10c), len: 603 aa. Possible penicillin-binding lipoprotein, probably located in periplasm, equivalent to Q9CBU6|ML1577 probable penicillin binding protein from Mycobacterium lepr [...]
relF protein networkhttps://string-db.org/network/83332.Rv2865Antitoxin RelF; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2.
relG protein networkhttps://string-db.org/network/83332.Rv2866Toxin RelG; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tu [...]
Rv2867c protein networkhttps://string-db.org/network/83332.Rv2867cGCN5-related N-acetyltransferase; Rv2867c, (MTV003.13c), len: 284 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in C-terminal part. See Vetting et al. 20 [...]
gcpE protein networkhttps://string-db.org/network/83332.Rv2868cProbable GcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
rip protein networkhttps://string-db.org/network/83332.Rv2869cMembrane bound metalloprotease; A probable intramembrane site-2 protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains. Cleaves PbpB (PBP3, FtsI) near 'A [...]
dxr protein networkhttps://string-db.org/network/83332.Rv2870c1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Be [...]
vapB43 protein networkhttps://string-db.org/network/83332.Rv2871Possible antitoxin VapB43; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC43.
vapC43 protein networkhttps://string-db.org/network/83332.Rv2872Possible toxin VapC43. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
mpt83 protein networkhttps://string-db.org/network/83332.Rv2873Cell surface lipoprotein Mpt83 (lipoprotein P23); Recombinant, non-modified protein stimulates secretion of cytokines (TNF-alpha, IL-6 and IL-12p40) by mouse macrophage cell lines in a TLR2-depen [...]
dipZ protein networkhttps://string-db.org/network/83332.Rv2874Rv2874, (MT2942, MTCY274.05), len: 695 aa. Possible dipZ, cytochrome c-type biogenesis protein (see citation below), probable integral membrane protein, similar in part to others or hypothetical [...]
mpt70 protein networkhttps://string-db.org/network/83332.Rv2875Major secreted immunogenic protein Mpt70; Rv2875, (MTCY274.06), len: 193 aa. Mpt70 (alternate gene name: mpb70), major secreted immunogenic protein MPT70 precursor (see citations below). Also sim [...]
Rv2876 protein networkhttps://string-db.org/network/83332.Rv2876Rv2876, (MTCY274.07), len: 104 aa. Possible conserved transmembrane protein, equivalent (but longer 16 aa) to Q9CBU2|ML1584 possible conserved membrane protein from Mycobacterium leprae (84 aa), [...]
Rv2877c protein networkhttps://string-db.org/network/83332.Rv2877cRv2877c, (MTCY274.08c), len: 287 aa. Probable conserved integral membrane protein, Mer family possibly involved in transport of mercury, similar to others, and to the fourth protein of the mercur [...]
mpt53 protein networkhttps://string-db.org/network/83332.Rv2878cSoluble secreted antigen Mpt53 precursor; Disulfide oxidoreductase that catalyzes the oxidation of reduced, unfolded secreted proteins to form disulfide bonds. Despite a weak homology to thioredo [...]
rlmN protein networkhttps://string-db.org/network/83332.Rv2879cConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family.
Rv2880c protein networkhttps://string-db.org/network/83332.Rv2880cRv2880c, (MTCY274.11c), len: 275 aa. Conserved hypothetical protein, highly similar in N-terminus to others e.g. O86754|SC6A9.22c hypothetical 40.4 KDA protein from Streptomyces coelicolor (368 a [...]
cdsA protein networkhttps://string-db.org/network/83332.Rv2881cRv2881c, (MTCY274.12c), len: 306 aa. Probable cdsA,phosphatidate cytidylyltransferase, integral membrane protein, equivalent to Q9CBU1|CDSA_MYCLE|ML1589 phosphatidate cytidylyltransferase from My [...]
frr protein networkhttps://string-db.org/network/83332.Rv2882cRibosome recycling factor Frr (ribosome releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficienc [...]
pyrH protein networkhttps://string-db.org/network/83332.Rv2883cProbable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase); Catalyzes the reversible phosphorylation of UMP to UDP.
Rv2884 protein networkhttps://string-db.org/network/83332.Rv2884Rv2884, (MTCY274.15), len: 252 aa. Probable transcriptional regulatory protein, highly similar to others e.g. Q05943|GLNR_STRCO|SCD84.26c transcriptional regulatory protein from Streptomyces coel [...]
Rv2885c protein networkhttps://string-db.org/network/83332.Rv2885cProbable transposase; Rv2885c, (MTCY274.16c), len: 460 aa. Probable transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop); In the N-terminal section; belongs to the trans [...]
Rv2886c protein networkhttps://string-db.org/network/83332.Rv2886cProbable resolvase; Rv2886c, (MTCY274.17c), len: 295 aa. Probable resolvase for IS1539. Contains PS00213 Lipocalin signature.
Rv2887 protein networkhttps://string-db.org/network/83332.Rv2887Rv2887, (MTCY274.18), len: 139 aa. Probable transcriptional regulatory protein, highly similar to Q9EX59|SC1A4.04 putative MarR-family transcriptional regulator from Streptomyces coelicolor (151 [...]
amiC protein networkhttps://string-db.org/network/83332.Rv2888cRv2888c, (MTCY274.19c), len: 473 aa. Probable amiC,amidase, equivalent to O33040|AMI3_MYCLE|AMIC|ML1596|MLCB250.65 putative amidase AMIC from Mycobacterium leprae (468 aa), FASTA scores: opt: 236 [...]
tsf protein networkhttps://string-db.org/network/83332.Rv2889cProbable elongation factor Tsf (EF-ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydro [...]
rpsB protein networkhttps://string-db.org/network/83332.Rv2890cRv2890c, (MTCY274.21c), len: 287 aa. rpsB, 30s ribosomal protein s2, equivalent to O33038|RS2_MYCLE|RPSB|ML1598|MLCB250.63 30S ribosomal protein S2 from Mycobacterium leprae (277 aa), FASTA score [...]
Rv2891 protein networkhttps://string-db.org/network/83332.Rv2891Conserved hypothetical protein; Rv2891, (MTCY274.22), len: 249 aa (C-terminus overlaps neigbouring ORF). Conserved hypothetical protein,similar in N-terminus to O69910|SC2E1.40c hypothetical 22.8 [...]
Rv2893 protein networkhttps://string-db.org/network/83332.Rv2893Rv2893, (MTCY274.24), len: 325 aa. Possible oxidoreductase, showing similarity with various proteins and/or oxidoreductases e.g. Q9AE05|RIF11 eleventh protein in the rif biosynthetic gene cluster [...]
xerC protein networkhttps://string-db.org/network/83332.Rv2894cProbable integrase/recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential t [...]
viuB protein networkhttps://string-db.org/network/83332.Rv2895cRv2895c, (MT2963, MTCY274.26c), len: 283 aa. Possible viuB, mycobactin utilization protein, highly similar to Q9RJ78|SCI41.06 hypothetical 31.5 KDA protein from Streptomyces coelicolor (280 aa), [...]
dprA protein networkhttps://string-db.org/network/83332.Rv2896cConserved hypothetical protein; May help load RecA onto ssDNA (By similarity). Belongs to the DprA/Smf family.
Rv2897c protein networkhttps://string-db.org/network/83332.Rv2897cRv2897c, (MTCY274.28c), len: 503 aa. Conserved hypothetical protein, possibly Mg-chelatase, highly similar to hypothetical proteins and chelatases e.g. Q9RTV0|DR1656 mg(2+) chelatase family prote [...]
Rv2898c protein networkhttps://string-db.org/network/83332.Rv2898cRv2898c, (MTCY274.29c), len: 128 aa. Conserved hypothetical protein, highly similar to O33024|YS98_MYCLE|ML1607|MLCB250.49 hypothetical 11.0 KDA protein from Mycobacterium leprae (96 aa), FASTA s [...]
fdhD protein networkhttps://string-db.org/network/83332.Rv2899cPossible FdhD protein homolog; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertio [...]
fdhF protein networkhttps://string-db.org/network/83332.Rv2900cUncharacterized oxidoreductase Rv2900c; Rv2900c, (MTCY274.31c), len: 779 aa. Possible fdhF,formate dehydrogenase, highly similar to others formate dehydrogenases and prokaryotic molybdopterin-con [...]
Rv2901c protein networkhttps://string-db.org/network/83332.Rv2901cConserved protein; Rv2901c, (MTCY274.32c), len: 101 aa. Conserved protein, very equivalent to O33023|ML1610|MLCB250.41 hypothetical 12.3 KDA protein from Mycobacterium leprae (101 aa), FASTA scor [...]
rnhB protein networkhttps://string-db.org/network/83332.Rv2902cProbable ribonuclease HII protein RnhB (RNase HII); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
lepB protein networkhttps://string-db.org/network/83332.Rv2903cRv2903c, (MTCY274.34c), len: 294 aa. Probable lepB,signal peptidase I (type II membrane protein) (see Braunstein & Belisle 2000), equivalent to O33021|LEP_MYCLE|ML1612|MLCB250.39 probable signal [...]
rplS protein networkhttps://string-db.org/network/83332.Rv2904c50S ribosomal protein L19 RplS; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
lppW protein networkhttps://string-db.org/network/83332.Rv2905Rv2905, (MTCY274.36), len: 314 aa. Probable lppW,conserved ala-rich lipoprotein, with slight similarity to beta-lactamases and hypothetical proteins e.g. Q9S1P7|SCJ9A.23 hypothetical 36.3 KDA pro [...]
trmD protein networkhttps://string-db.org/network/83332.Rv2906ctRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs.
rimM protein networkhttps://string-db.org/network/83332.Rv2907cProbable 16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts [...]
Rv2908c protein networkhttps://string-db.org/network/83332.Rv2908cRv2908c, (MTCY274.40c), len: 80 aa. Conserved hypothetical protein, equivalent to O33015|YT08_MYCLE from Mycobacterium leprae (80 aa), FASTA scores: opt: 492, E(): 3.1e-29, (93.75% identity in 80 [...]
rpsP protein networkhttps://string-db.org/network/83332.Rv2909cRv2909c, (MTCY274.41c), len: 162 aa. rpsP, 30S ribosomal protein S16, equivalent to O33014|RS16_MYCLE 30S ribosomal protein S16 from Mycobacterium leprae (160 aa),FASTA scores: opt: 828, E(): 1.6 [...]
Rv2910c protein networkhttps://string-db.org/network/83332.Rv2910cRv2910c, (MTCY274.42c), len: 147 aa. Conserved hypothetical protein, showing some similarity with hypothetical proteins from other organisms e.g. Q9JN76|MMYY hypothetical 17.4 KDA protein from St [...]
dacB2 protein networkhttps://string-db.org/network/83332.Rv2911Rv2911, (MTCY274.43), len: 291 aa. Probable dacB2,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein), an ala-rich protein. Highly similar (except in N-terminus) to Q9CCM2|ML0691 put [...]
Rv2912c protein networkhttps://string-db.org/network/83332.Rv2912cRv2912c, (MTCY274.44c), len: 195 aa. Probable transcription regulatory protein, TetR family, showing similarity with others e.g. Q9K3V9|SCD10.17 putative TetR-family transcriptional from Streptom [...]
Rv2913c protein networkhttps://string-db.org/network/83332.Rv2913cRv2913c, (MTCY338.01c, MTCY274.45c), len: 611 aa. Possible D-amino acid aminohydrolase, similar (principally in N-terminus) to D-amino acid aminohydrolases e.g. Q9V2D3|NDAD|PAB0090 D-aminoacylase [...]
pknI protein networkhttps://string-db.org/network/83332.Rv2914cSerine/threonine-protein kinase PknI; Plays an important role in slowing down the growth of mycobacteria within the infected host; Belongs to the protein kinase superfamily. Ser/Thr protein kinas [...]
Rv2915c protein networkhttps://string-db.org/network/83332.Rv2915cConserved protein; Rv2915c, (MTCY338.03c), len: 370 aa. Conserved protein, posssibly XAA-pro dipeptidase (prolidase), highly similar to CAC38796|SCI39.08c conserved hypothetical protein from Stre [...]
ffh protein networkhttps://string-db.org/network/83332.Rv2916cProbable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the h [...]
Rv2917 protein networkhttps://string-db.org/network/83332.Rv2917Rv2917, (MTCY338.05), len: 626 aa. Conserved hypothetical ala-, arg-rich protein, highly similar (but longer 34 aa) to O33011|ML1624|MLCB250.18C hypothetical 65.2 KDA protein from Mycobacterium l [...]
glnD protein networkhttps://string-db.org/network/83332.Rv2918cBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory protein (GlnB), in response to the nitrogen status of the cell that G [...]
glnB protein networkhttps://string-db.org/network/83332.Rv2919cProbable nitrogen regulatory protein P-II GlnB; In nitrogen-limiting conditions, when the ratio of Gln to 2- ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadeny [...]
amt protein networkhttps://string-db.org/network/83332.Rv2920cProbable ammonium-transport integral membrane protein Amt; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
ftsY protein networkhttps://string-db.org/network/83332.Rv2921cProbable cell division protein FtsY (SRP receptor) (signal recognition particle receptor); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as [...]
acyP protein networkhttps://string-db.org/network/83332.Rv2922ARv2922A, len: 93 aa. Probable acyP, acylphosphatase (acylphosphate phosphohydrolase), highly similar to others e.g. Q9ZBQ3|SC7A1.20 putative acylphosphatase from Streptomyces coelicolor (93 aa), [...]
smc protein networkhttps://string-db.org/network/83332.Rv2922cProbable chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family.
Rv2923c protein networkhttps://string-db.org/network/83332.Rv2923cConserved protein; Rv2923c, (MTCY338.12c), len: 137 aa. Conserved protein, showing similarity with other hypothetical proteins e.g. P24246|YHFA_ECOLI|B3356|Z4717|ECS4207 from Escherichia coli str [...]
fpg protein networkhttps://string-db.org/network/83332.Rv2924cProbable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase); Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recogniz [...]
rnc protein networkhttps://string-db.org/network/83332.Rv2925cProbable ribonuclease III Rnc (RNase III); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S a [...]
Rv2926c protein networkhttps://string-db.org/network/83332.Rv2926cConserved protein; Rv2926c, (MTCY338.15c), len: 207 aa. Conserved protein, equivalent to O69468|ML1660|MLCB1243.14 hypothetical 23.5 KDA protein from Mycobacterium leprae (217 aa), FASTA scores: [...]
Rv2927c protein networkhttps://string-db.org/network/83332.Rv2927cRv2927c, (MTCY338.16c), len: 245 aa. Conserved hypothetical protein, equivalent to Q9CBS6|ML1661|MLCB1243.13 (alias O69467) hypothetical protein from Mycobacterium leprae (247 aa), FASTA scores: [...]
tesA protein networkhttps://string-db.org/network/83332.Rv2928Probable thioesterase TesA; Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to th [...]
Rv2929 protein networkhttps://string-db.org/network/83332.Rv2929Hypothetical protein; Rv2929, (MTCY338.18), len: 103 aa. Hypothetical unknown protein; some weak similarity to C-terminal half of P18319|UREG_KLEAE urease accessory protein from klebsiella aeroge [...]
fadD26 protein networkhttps://string-db.org/network/83332.Rv2930Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which ar [...]
ppsA protein networkhttps://string-db.org/network/83332.Rv2931Phenolpthiocerol synthesis type-I polyketide synthase PpsA; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield ph [...]
ppsB protein networkhttps://string-db.org/network/83332.Rv2932Phenolpthiocerol synthesis type-I polyketide synthase PpsB; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield ph [...]
ppsC protein networkhttps://string-db.org/network/83332.Rv2933Phenolpthiocerol synthesis type-I polyketide synthase PpsC; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield ph [...]
ppsD protein networkhttps://string-db.org/network/83332.Rv2934Phenolpthiocerol synthesis type-I polyketide synthase PpsD; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield ph [...]
ppsE protein networkhttps://string-db.org/network/83332.Rv2935Phenolpthiocerol synthesis type-I polyketide synthase PpsE; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield ph [...]
drrA protein networkhttps://string-db.org/network/83332.Rv2936Daunorubicin-dim-transport ATP-binding protein ABC transporter DrrA; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Responsible for energy coupling to the transpor [...]
drrB protein networkhttps://string-db.org/network/83332.Rv2937Daunorubicin-dim-transport integral membrane protein ABC transporter DrrB; Part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible for the translocatio [...]
drrC protein networkhttps://string-db.org/network/83332.Rv2938Probable daunorubicin-dim-transport integral membrane protein ABC transporter DrrC; Probably part of the ABC transporter complex DrrABC involved in doxorubicin resistance. Probably responsible fo [...]
papA5 protein networkhttps://string-db.org/network/83332.Rv2939Possible conserved polyketide synthase associated protein PapA5; Catalyzes diesterification of phthiocerol, phthiodiolone, and phenolphthiocerol with mycocerosic acids, the final step in the phth [...]
mas protein networkhttps://string-db.org/network/83332.Rv2940cRv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa. Probable mas, mycocerosic acid synthase membrane associated, multifunctional enzyme (see citations below),almost identical to Q02251|MCAS_MYCBO [...]
fadD28 protein networkhttps://string-db.org/network/83332.Rv2941Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids (C22-24 fatty acids) as acyl-adenylates (acyl-AMP), which ar [...]
mmpL7 protein networkhttps://string-db.org/network/83332.Rv2942Conserved transmembrane transport protein MmpL7; Required for export of phthiocerol dimycocerosate (PDIM) to the cell wall. Essential for normal replication during the active-growth phase of the [...]
Rv2943 protein networkhttps://string-db.org/network/83332.Rv2943Rv2943, (MTCY24G1.06c), len: 413 aa. Probable transposase for insertion sequence IS1533, similar to other transposases e.g. P15025|ISTA_ECOLI ista protein (insertion sequence IS21) from Escherich [...]
Rv2943A protein networkhttps://string-db.org/network/83332.Rv2943ARv2943A, len: 176 aa. Possible transposase, similar to many e.g. AJ238712|MBO238712_2 putative transposase (IS21-l) from Mycobacterium bovis BCG (266 aa), FASTA scores: opt: 762, E(): 0, (100.0% [...]
Rv2944 protein networkhttps://string-db.org/network/83332.Rv2944Rv2944, (MTCY24G1.05c), len: 238 aa. Possible transposase for IS1533, similar to is-element proteins e.g. P15026|ISTB_ECOLI istb protein from Escherichia coli (265 aa), FASTA scores: opt: 475, E [...]
lppX protein networkhttps://string-db.org/network/83332.Rv2945cProbable conserved lipoprotein LppX; Might be involved in translocating phthiocerol dimycocerosates (PDIM) from the cell membrane to the outer membrane; PDIM forms part of the cell wall; Belongs [...]
pks1 protein networkhttps://string-db.org/network/83332.Rv2946cProbable polyketide synthase Pks1; May play a role in phthiocerol biosynthesis.
pks15 protein networkhttps://string-db.org/network/83332.Rv2947cRv2947c, (MTCY24G1.02), len: 496 aa. Probable pks15,polyketide synthase. Almost identical to G560508|Q50469 PKS002B protein from Mycobacterium tuberculosis (495 aa),FASTA scores: opt: 3270, E(): [...]
fadD22 protein networkhttps://string-db.org/network/83332.Rv2948cP-hydroxybenzoyl-AMP ligase FadD22; Catalyzes the adenylation of p-hydroxybenzoic acid (pHBA) to form p-hydroxybenzoic acid-AMP (pHBA-AMP), which is converted directly to p-hydroxybenzoyl-S-FadD2 [...]
Rv2949c protein networkhttps://string-db.org/network/83332.Rv2949cChorismate pyruvate lyase; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) [...]
fadD29 protein networkhttps://string-db.org/network/83332.Rv2950cFatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of the long-chain fatty acids (C22- 24 fatty acids) as acyl-adenylates (acyl-AMP), whi [...]
Rv2951c protein networkhttps://string-db.org/network/83332.Rv2951cPossible oxidoreductase; Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compound [...]
Rv2952 protein networkhttps://string-db.org/network/83332.Rv2952Possible methyltransferase (methylase); Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthioce [...]
Rv2953 protein networkhttps://string-db.org/network/83332.Rv2953Enoyl reductase; Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
Rv2954c protein networkhttps://string-db.org/network/83332.Rv2954cHypothetical protein; Rv2954c, (MTCY349.36), len: 241 aa. Hypothetical unknown protein. Equivalent to AAK47354 from Mycobacterium tuberculosis strain CDC1551 (199 aa) but longer 42 aa. This regio [...]
Rv2955c protein networkhttps://string-db.org/network/83332.Rv2955cConserved protein; Rv2955c, (MTCY349.34), len: 321 aa. Conserved protein, similar to others e.g. Q98NV5|MLL9724 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (284 aa),FASTA scores [...]
Rv2956 protein networkhttps://string-db.org/network/83332.Rv2956Conserved protein; Rv2956, (MTCY349.33c), len: 243 aa. Conserved protein, highly similar to O86299|GSC GSC protein from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa), FASTA s [...]
Rv2957 protein networkhttps://string-db.org/network/83332.Rv2957Possible glycosyl transferase; Involved in glycosylation steps downstream of mono-O-methyl- glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl- rhamnosyl-phenolphthiocerol dimyco [...]
Rv2958c protein networkhttps://string-db.org/network/83332.Rv2958cPossible glycosyl transferase; Involved in glycosylation steps downstream of mono-O-methyl- glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl- rhamnosyl-phenolphthiocerol dimyco [...]
Rv2959c protein networkhttps://string-db.org/network/83332.Rv2959cPossible methyltransferase (methylase); Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthioce [...]
Rv2960c protein networkhttps://string-db.org/network/83332.Rv2960cHypothetical protein; Rv2960c, (MT3036, MTCY349.28), len: 82 aa. Hypothetical unknown protein, equivalent to AAK47362 from Mycobacterium tuberculosis strain CDC1551 (116 aa) but shorter 34 aa. Sh [...]
Rv2961 protein networkhttps://string-db.org/network/83332.Rv2961Probable transposase; Rv2961, (MTCY349.26c), len: 129 aa. Probable transposase, highly similar to C-terminus of O50414|Rv3387|MTV004.45 putative transposase from Mycobacterium tuberculosis (225 a [...]
Rv2962c protein networkhttps://string-db.org/network/83332.Rv2962cPossible glycosyl transferase; Catalyzes the transfer of the first rhamnosyl residue on p- hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O- methylation at position 2 of the [...]
Rv2963 protein networkhttps://string-db.org/network/83332.Rv2963Rv2963, (MTCY349.24c), len: 406 aa. Probable integral membrane protein.
purU protein networkhttps://string-db.org/network/83332.Rv2964Probable formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
kdtB protein networkhttps://string-db.org/network/83332.Rv2965cPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD [...]
Rv2966c protein networkhttps://string-db.org/network/83332.Rv2966cRv2966c, (MTCY349.21), len: 188 aa. Possible methyltransferase, equivalent (but shorter 36 aa) to O69465|MLCB1243.09 hypothetical 23.0 KDA protein from Mycobacterium leprae (220 aa), FASTA scores [...]
pca protein networkhttps://string-db.org/network/83332.Rv2967cProbable pyruvate carboxylase Pca (pyruvic carboxylase); Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfe [...]
Rv2968c protein networkhttps://string-db.org/network/83332.Rv2968cRv2968c, (MTCY349.19), len: 210 aa. Probable conserved integral membrane protein, equivalent to O69464 putative integral membrane protein from Mycobacterium leprae (214 aa), FASTA scores: opt: 10 [...]
Rv2969c protein networkhttps://string-db.org/network/83332.Rv2969cRv2969c, (MTCY349.18), len: 255 aa. Possible conserved membrane or exported protein, equivalent to Q9CBS4|ML1667 possible conserved membrane protein from Mycobacterium leprae (264 aa), FASTA scor [...]
Rv2970A protein networkhttps://string-db.org/network/83332.Rv2970ARv2970A, len: 56 aa. Conserved hypothetical protein,similar to C-terminal part of several oxidoreductases e.g. Rv2971|Z83018|MTCY349_22 from Mycobacterium tuberculosis (282 aa), FASTA scores: opt [...]
lipN protein networkhttps://string-db.org/network/83332.Rv2970cProbable lipase/esterase LipN; Non specific carboxylic ester hydrolase. Hydrolyzes various pNP-esters, with a preference for short carbon chain substrates. Can also hydrolyze tributyrin to di- an [...]
Rv2971 protein networkhttps://string-db.org/network/83332.Rv2971Rv2971, (MTCY349.16c), len: 282 aa. Probable oxidoreductase, possibly aldo/keto reductase, equivalent to O69462 putative oxidoreductase from Mycobacterium leprae (282 aa), FASTA scores: opt: 1495 [...]
Rv2972c protein networkhttps://string-db.org/network/83332.Rv2972cRv2972c, (MTCY349.15), len: 237 aa. Possible conserved membrane or exported protein, equivalent (but longer 52 aa) to O69461|MLCB1243.02 hypothetical 20.5 KDA protein from Mycobacterium leprae (1 [...]
recG protein networkhttps://string-db.org/network/83332.Rv2973cProbable ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA [...]
Rv2974c protein networkhttps://string-db.org/network/83332.Rv2974cRv2974c, (MTCY349.13), len: 470 aa. Conserved hypothetical ala-rich protein, highly similar to others e.g. C-terminus of Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA protein from Streptomyces coelicolor [...]
Rv2975c protein networkhttps://string-db.org/network/83332.Rv2975cRv2975c, (MTCY349.12), len: 84 aa. Conserved hypothetical protein, similar to N-terminus of others e.g. Q9ZBR4|SC7A1.09 hypothetical 59.5 KDA protein from Streptomyces coelicolor (589 aa), FASTA [...]
ung protein networkhttps://string-db.org/network/83332.Rv2976cProbable uracil-DNA glycosylase Ung (UDG); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosin [...]
thiL protein networkhttps://string-db.org/network/83332.Rv2977cProbable thiamine-monophosphate kinase ThiL (thiamine-phosphate kinase); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the act [...]
Rv2978c protein networkhttps://string-db.org/network/83332.Rv2978cProbable transposase; Rv2978c, (MTCY349.09), len: 459 aa. Probable transposase for IS1538, very similar to several other putative transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q108 [...]
Rv2979c protein networkhttps://string-db.org/network/83332.Rv2979cProbable resolvase; Rv2979c, (MTCY349.08), len: 194 aa. Probable resolvase for IS1538, with low level matches to transposon resolvases; highly similar from aa 101 to YX1C_MYCTU|Q10831 from Mycoba [...]
Rv2980 protein networkhttps://string-db.org/network/83332.Rv2980Rv2980, (MTCY349.07c), len: 181 aa. Possible conserved secreted protein, equivalent to Q9CBS1 possible secreted protein from Mycobacterium leprae (191 aa), FASTA scores: opt: 794, E(): 2.3e-40, ( [...]
ddlA protein networkhttps://string-db.org/network/83332.Rv2981cProbable D-alanine--D-alanine ligase DdlA (D-alanylalanine synthetase) (D-ala-D-ala ligase); Catalyzes the ATP-driven ligation of two D-alanine molecules to form the D-alanyl-D-alanine dipeptide. [...]
gpdA2 protein networkhttps://string-db.org/network/83332.Rv2982cGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Rv2982c, (MTCY349.05), len: 334 aa. Probable gpdA2 (alternate gene name: gpsA), glycerol-3-phosphate dehydrogenase [NAD(P)+], equivalent to Q9CBR9|GP [...]
fbiD protein networkhttps://string-db.org/network/83332.Rv2983Conserved hypothetical alanine rich protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP w [...]
ppk1 protein networkhttps://string-db.org/network/83332.Rv2984Polyphosphate kinase PPK (polyphosphoric acid kinase) (ATP-polyphosphate phosphotransferase); Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate [...]
mutT1 protein networkhttps://string-db.org/network/83332.Rv2985Possible hydrolase MutT1; May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo- dGTP) from DNA and the nucleotide pool [...]
hupB protein networkhttps://string-db.org/network/83332.Rv2986cDNA-binding protein HU homolog HupB (histone-like protein) (HLP) (21-kDa laminin-2-binding protein); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to [...]
leuD protein networkhttps://string-db.org/network/83332.Rv2987c3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. Leu [...]
leuC protein networkhttps://string-db.org/network/83332.Rv2988c3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
Rv2989 protein networkhttps://string-db.org/network/83332.Rv2989Rv2989, (MTV012.03), len: 233 aa. Probable transcriptional regulator (ala-rich protein), highly similar to O86533|SC1C2.33c putative transcriptional regulator from Streptomyces coelicolor (238 aa [...]
Rv2990c protein networkhttps://string-db.org/network/83332.Rv2990cHypothetical protein; Rv2990c, (MTV012.04c), len: 286 aa. Hypothetical unknown protein.
Rv2991 protein networkhttps://string-db.org/network/83332.Rv2991Conserved protein; Rv2991, (MTV012.05), len: 163 aa. Conserved protein,similar to others e.g. Q9K3X7|2SCG61.39. hypothetical 17.6 KDA protein from Streptomyces coelicolor (153 aa), FASTA scores: [...]
gltS protein networkhttps://string-db.org/network/83332.Rv2992cGlutamyl-tRNA synthetase GltS (glutamate--tRNA ligase) (glutamyl-tRNA synthase) (GLURS); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated b [...]
Rv2993c protein networkhttps://string-db.org/network/83332.Rv2993cRv2993c, (MTV012.07c), len: 239 aa. Possible 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase, equivalent to O33119|ML1689|MLCB637.28 possible 2-hydroxyhepta-2,4-diene- 1,7-dioate isomerase from Myc [...]
Rv2994 protein networkhttps://string-db.org/network/83332.Rv2994Rv2994, (MTV012.08), len: 445 aa. Probable conserved integral membrane protein, member of major facilitator superfamily (MFS) possibly involved in transport of drug. C-terminal part highly simila [...]
leuB protein networkhttps://string-db.org/network/83332.Rv2995cProbable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-met [...]
serA1 protein networkhttps://string-db.org/network/83332.Rv2996cProbable D-3-phosphoglycerate dehydrogenase SerA1 (PGDH); Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine bio [...]
Rv2997 protein networkhttps://string-db.org/network/83332.Rv2997Rv2997, (MTV012.11), len: 480 aa. Possible ala-rich dehydrogenase, similar to others dehydrogenases and hypothetical proteins e.g. Q9EYI5 putative dehydrogenase from Streptomyces nogalater (472 a [...]
Rv2998 protein networkhttps://string-db.org/network/83332.Rv2998Hypothetical protein; Rv2998, (MTV012.12), len: 153 aa. Hypothetical unknown protein. Note that equivalent to AAK47405 Hypothetical 19.4 kDa protein from Mycobacterium tuberculosis strain CDC1551 [...]
Rv2998A protein networkhttps://string-db.org/network/83332.Rv2998ARv2998A, len: 67 aa. Probable conserved hypothetical protein, (possibly gene fragment), highly similar to central part of two-component sensor proteins e.g. O07777|Rv0601c|MTCY19H5.21 two compone [...]
lppY protein networkhttps://string-db.org/network/83332.Rv2999Rv2999, (MTV012.13), len: 321 aa. Probable lppY,conserved lipoprotein, highly similar to O07774|LPQO|Rv0604|MTCY19H5.18c putative lipoprotein from Mycobacterium tuberculosis (316 aa), FASTA score [...]
Rv3000 protein networkhttps://string-db.org/network/83332.Rv3000Rv3000, (MTV012.14), len: 219 aa. Possible conserved transmembrane protein, similar to various membrane proteins e.g. P77307|YBBM_ECOLI|B0491 hypothetical 28.2 KDA protein (potential integral mem [...]
ilvC protein networkhttps://string-db.org/network/83332.Rv3001cKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2 [...]
ilvN protein networkhttps://string-db.org/network/83332.Rv3002cProbable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS); Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the b [...]
ilvB1 protein networkhttps://string-db.org/network/83332.Rv3003cAcetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase); Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway o [...]
cfp6 protein networkhttps://string-db.org/network/83332.Rv3004Rv3004, (MT3084.1, MTV012.18), len: 112 aa. Cfp6,low molecular weight protein antigen 6 (CFP-6) (See Bhaskar et al., 2000). Weak homology with Q9RKZ5|SC6D7.02 putative membrane protein from Strep [...]
Rv3005c protein networkhttps://string-db.org/network/83332.Rv3005cRv3005c, (MTV012.19c), len: 279 aa. Conserved hypothetical protein, equivalent to O33110|MLCB637.18|ML1698 hypothetical 29.5 KDA protein from Mycobacterium leprae (277 aa), FASTA scores: opt: 124 [...]
lppZ protein networkhttps://string-db.org/network/83332.Rv3006Rv3006, (MTV012.20), len: 373 aa. Probable lppZ,conserved lipoprotein, equivalent to O33109|MLCB637.17C|ML1699 putative lipoprotein from M. leprae (372 aa), FASTA scores: opt: 2211, E(): 4.3e-100 [...]
Rv3007c protein networkhttps://string-db.org/network/83332.Rv3007cRv3007c, (MTV012.21c), len: 204 aa. Possible oxidoreductase, similar to Q9EWU5|3SC5B7.04c putative oxidoreductase from Streptomyces coelicolor (162 aa), FASTA scores: opt: 376, E(): 1.5e-18, (41. [...]
Rv3008 protein networkhttps://string-db.org/network/83332.Rv3008Hypothetical protein; Rv3008, (MTV012.22), len: 207 aa (start uncertain). Hypothetical unknown protein.
gatB protein networkhttps://string-db.org/network/83332.Rv3009cProbable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylat [...]
pfkA protein networkhttps://string-db.org/network/83332.Rv3010cProbable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing st [...]
gatA protein networkhttps://string-db.org/network/83332.Rv3011cProbable glutamyl-tRNA(GLN) amidotransferase (subunit A) GatA (Glu-ADT subunit A); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) [...]
gatC protein networkhttps://string-db.org/network/83332.Rv3012cProbable glutamyl-tRNA(GLN) amidotransferase (subunit C) GatC (Glu-ADT subunit C); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylat [...]
Rv3013 protein networkhttps://string-db.org/network/83332.Rv3013Conserved protein; Rv3013, (MTV012.27), len: 218 aa. Conserved protein,equivalent to O33103|MLCB637_11c hypothetical 24.4 KDA protein from Mycobacterium leprae (230 aa), FASTA scores: opt: 1188, [...]
ligA protein networkhttps://string-db.org/network/83332.Rv3014cDNA ligase [NAD dependent] LigA (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in doubl [...]
Rv3015c protein networkhttps://string-db.org/network/83332.Rv3015cRv3015c, (MTV012.29c), len: 337 aa. Conserved hypothetical protein, equivalent to Q9CBR6|ML1706 hypothetical protein from Mycobacterium leprae (337 aa),FASTA scores: opt: 1703, E(): 3.1e-92, (78. [...]
lpqA protein networkhttps://string-db.org/network/83332.Rv3016Rv3016, (MTV012.30), len: 209 aa. Probable lpqA,lipoprotein. Contains signal sequence and appropriately positioned PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
esxQ protein networkhttps://string-db.org/network/83332.Rv3017cRv3017c, (MT3097, MTV012.31c), len: 120 aa. EsxQ,ESAT-6 like protein (see citation below), possibly secreted protein, very similar to AAK47433|MT3104 putative secreted ESAT-6 like protein 9 from [...]
PE27A protein networkhttps://string-db.org/network/83332.Rv3018ARv3018A, len: 28 aa. PE27A, Member of Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002), most similar to Rv0285 (102 aa), FASTA scores: opt: 147, E(): 3.5e-05, (92.85% identity [...]
PPE46 protein networkhttps://string-db.org/network/83332.Rv3018cRv3018c, (MTV012.32c), len: 434 aa. PPE46, Member of PPE family but lacks Gly, Ala rich repeats at C-terminal domain, closest to MTCY261.19. See citation below. Also very similar to following ORF [...]
esxR protein networkhttps://string-db.org/network/83332.Rv3019cRv3019c, (MT3104, MTV012.33c), len: 96 aa. EsxR,secreted ESAT-6 like protein (see citations below), most similar to O53693|AAK44525|Rv0288|CFP7|MT0301|MTV035.16 10 KDA antigen CFP7 (low molecular [...]
esxS protein networkhttps://string-db.org/network/83332.Rv3020cRv3020c, (MTV012.34c), len: 97 aa. EsxS, ESAT-6 like protein. PE-family related protein; distant member of the Mycobacterium tuberculosis PE family, similar to AAK44524|MT0300 PE family protein f [...]
PE29 protein networkhttps://string-db.org/network/83332.Rv3022ARv3022A, len: 104 aa. PE29, Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002), similar to many others e.g. Rv0285|AL021930_12 from Mycobacterium tuberculosis (102 [...]
PPE48 protein networkhttps://string-db.org/network/83332.Rv3022cRv3021c, (MTV012.35c), len: 358 aa. PPE47, Member of Mycobacterium tuberculosis PPE family. Should be continuation of upstream ORF MTV012.36c but is frameshifted due to missing base at 36448 in v [...]
Rv3023c protein networkhttps://string-db.org/network/83332.Rv3023cProbable transposase; Rv3023c, (MTV012.38c), len: 415 aa. Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family,signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c a [...]
trmU protein networkhttps://string-db.org/network/83332.Rv3024cProbable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
iscS protein networkhttps://string-db.org/network/83332.Rv3025cIscS-like cysteine desulfurase; Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Participates in the biosynthesis of metalloclusters by providing the inorgan [...]
Rv3026c protein networkhttps://string-db.org/network/83332.Rv3026cRv3026c, (MTV012.41c), len: 304 aa. Conserved hypothetical protein, similar to Q9RCZ0|SCM10.08C putative acyltransferase from Streptomyces coelicolor (275 aa),FASTA scores: opt: 393, E(): 2.2e-17 [...]
Rv3027c protein networkhttps://string-db.org/network/83332.Rv3027cGCN5-related N-acetyltransferase; Rv3027c, (MTV012.42c), len: 281 aa. Probable acetyltransferase. Contains GNAT (Gcn5-related N-acetyltransferase) domain in N-terminal part. See Vetting et al. 20 [...]
fixB protein networkhttps://string-db.org/network/83332.Rv3028cElectron transfer flavoprotein subunit alpha; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respirator [...]
fixA protein networkhttps://string-db.org/network/83332.Rv3029cElectron transfer flavoprotein subunit beta; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory [...]
Rv3030 protein networkhttps://string-db.org/network/83332.Rv3030Conserved protein; Probable S-adenosylmethionine-dependent methyltransferase required for the 6-O-methylation of the polysaccharide backbone of 6-O- methylglucosyl lipopolysaccharides (MGLP).
Rv3031 protein networkhttps://string-db.org/network/83332.Rv3031Conserved protein; Catalyzes the formation of branch points in alpha-glucans by cleavage of an alpha-1,4 glycosidic bond and subsequent transfer of the cleaved-off oligosaccharide to a new alpha- [...]
Rv3032 protein networkhttps://string-db.org/network/83332.Rv3032Alpha (1->4) glucosyltransferase; Glucosyltransferase that uses UDP-glucose as the sugar donor to elongate alpha-(1->4)-glucans. Is involved in the biosynthesis of both 6-O-methylglucosyl lipopol [...]
Rv3032A protein networkhttps://string-db.org/network/83332.Rv3032ARv3032A, len: 129 aa. Conserved protein.
Rv3033 protein networkhttps://string-db.org/network/83332.Rv3033Unknown protein; Rv3033, (MTV012.48), len: 182 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
Rv3034c protein networkhttps://string-db.org/network/83332.Rv3034cPossible transferase; Putative acetyltransferase that is probably involved in the biosynthesis of 6-O-methylglucosyl lipopolysaccharides (MGLP).
Rv3035 protein networkhttps://string-db.org/network/83332.Rv3035Conserved protein; Rv3035, (MTV012.50), len: 360 aa. Conserved protein,equivalent to Q9CBR0|ML1720 hypothetical protein from Mycobacterium leprae (364 aa), FASTA scores: opt: 1963,E(): 1.4e-108, [...]
TB22.2 protein networkhttps://string-db.org/network/83332.Rv3036cProbable conserved secreted protein TB22.2; Hydrolyzes ester substrates carbon chain lengths ranging from C2 to C14. In vitro, acetate (C2), butyrate (C4) and caprylate (C6) are hydrolyzed with h [...]
Rv3037c protein networkhttps://string-db.org/network/83332.Rv3037cRv3037c, (MTV012.52c), len: 358 aa. Conserved hypothetical protein, similar in part to others e.g. O86799|SC6G4.36c from Streptomyces coelicolor (426 aa),FASTA scores: opt: 545, E(): 5.5e-27, (36 [...]
Rv3038c protein networkhttps://string-db.org/network/83332.Rv3038cConserved protein; Rv3038c, (MTV012.53c), len: 327 aa. Conserved protein, equivalent to Q9CBQ9|ML1723 hypothetical protein from Mycobacterium leprae (327 aa), FASTA scores: opt: 1843, E(): 6.1e-1 [...]
echA17 protein networkhttps://string-db.org/network/83332.Rv3039cProbable enoyl-CoA hydratase EchA17 (crotonase) (unsatured acyl-CoA hydratase) (enoyl hydrase); Could possibly oxidize fatty acids using specific components.
Rv3040c protein networkhttps://string-db.org/network/83332.Rv3040cConserved protein; Rv3040c, (MTV012.55c), len: 288 aa. Conserved protein, highly similar to Q9XA40|SCH17.07c hypothetical protein from Streptomyces coelicolor (312 aa), FASTA scores: opt: 648, E( [...]
Rv3041c protein networkhttps://string-db.org/network/83332.Rv3041cRv3041c, (MTV012.56c), len: 287 aa. Probable conserved ATP-binding protein ABC transporter (see citation below), equivalent to Q9CBQ7|ML1726 putative ABC transporter protein ATP-binding protein f [...]
serB2 protein networkhttps://string-db.org/network/83332.Rv3042cProbable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase); Catalyzes the dephosphorylation of O-phospho-L-serine into L- serine, a step in the L-serine biosynthet [...]
ctaD protein networkhttps://string-db.org/network/83332.Rv3043cProbable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1); Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subuni [...]
fecB protein networkhttps://string-db.org/network/83332.Rv3044Rv3044, (MTV012.59), len: 359 aa. Probable fecB,FeIII dicitrate-binding periplasmic lipoprotein (see citation below), equivalent to Q9CBQ4|FECB|ML1729 putative FEIII-dicitrate transporter lipopro [...]
adhC protein networkhttps://string-db.org/network/83332.Rv3045Rv3045, (MTV012.60), len: 346 aa. Probable adhC,NADP-dependent alcohol dehydrogenase, equivalent to Q9CBQ3|ADHA|ML1730 alcohol dehydrogenases from Mycobacterium leprae (362 aa), FASTA scores: opt [...]
Rv3046c protein networkhttps://string-db.org/network/83332.Rv3046cConserved protein; Rv3046c, (MTV012.61c), len: 124 aa. Conserved protein, similar to several hypothetical mycobacterial proteins e.g. Q50171|ML2258 U296W hypothetical protein from Mycobacterium l [...]
Rv3047c protein networkhttps://string-db.org/network/83332.Rv3047cHypothetical protein; Rv3047c, (MTV012.62c), len: 94 aa. Hypothetical unknown protein.
nrdF2 protein networkhttps://string-db.org/network/83332.Rv3048cRibonucleoside-diphosphate reductase subunit beta nrdF2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleot [...]
Rv3049c protein networkhttps://string-db.org/network/83332.Rv3049cRv3049c, (MTV012.64c), len: 524 aa. Probable monooxygenase, similar to several monooxygenases e.g. Q9I3H5|PA1538 probable flavin-containing monooxygenase from Pseudomonas aeruginosa (527 aa), FAS [...]
Rv3050c protein networkhttps://string-db.org/network/83332.Rv3050cRv3050c, (MTV012.65c), len: 246 aa. Probable transcriptional regulatory protein TetR-family, equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa), FASTA scores: opt: 1381,(E [...]
nrdE protein networkhttps://string-db.org/network/83332.Rv3051cRibonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [...]
nrdI protein networkhttps://string-db.org/network/83332.Rv3052cProbable NrdI protein; Probably involved in ribonucleotide reductase function.
nrdH protein networkhttps://string-db.org/network/83332.Rv3053cProbable glutaredoxin electron transport component of NRDEF (glutaredoxin-like protein) NrdH; Rv3053c, (MTCY22D7.29), len: 79 aa. Probable nrdH,glutaredoxin-like protein, equivalent to Q9CBP8|NRD [...]
Rv3054c protein networkhttps://string-db.org/network/83332.Rv3054cRv3054c, (MTCY22D7.28), len: 184 aa. Conserved hypothetical protein, similar to Q9RD22|SCM1.21 putative secreted protein from Streptomyces coelicolor (187 aa),FASTA scores: opt: 651, E(): 1.5e-33 [...]
Rv3055 protein networkhttps://string-db.org/network/83332.Rv3055Rv3055, (MTCY22D7.26c), len: 204 aa. Possible transcriptional regulatory protein, similar to Q9RD23|SCM1.20c putative TetR-family transcriptional regulator from Streptomyces coelicolor (234 aa), [...]
dinP protein networkhttps://string-db.org/network/83332.Rv3056DNA polymerase IV 2; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or mi [...]
Rv3057c protein networkhttps://string-db.org/network/83332.Rv3057cRv3057c, (MTCY22D7.24), len: 287 aa. Probable oxidoreductase, probably short-chain alcohol dehydrogenase/reductase. Equivalent to Q9CBP7|ML1740 possible short chain dehydrogenases/reductase from [...]
Rv3058c protein networkhttps://string-db.org/network/83332.Rv3058cRv3058c, (MTCY22D7.23), len: 216 aa. Possible transcriptional regulatory protein, TetR-family, showing reasonable similarity to others e.g. AAK48337|MT3970 from Mycobacterium tuberculosis strain [...]
cyp136 protein networkhttps://string-db.org/network/83332.Rv3059Rv3059, (MTCY22D7.22c), len: 492 aa. Probable cyp136, cytochrome P450 136, similar to other cytochrome P450-dependent oxidases e.g. Q59990|CYP120|CYP|SLR0574 putative cytochrome P450 120 from Syn [...]
Rv3060c protein networkhttps://string-db.org/network/83332.Rv3060cRv3060c, (MTCY22D7.21), len: 490 aa. Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Me [...]
fadE22 protein networkhttps://string-db.org/network/83332.Rv3061cRv3061c, (MTCY22D7.20), len: 721 aa. Probable fadE22, Acyl-CoA Dehydrogenase, similar to many e.g. AAK44503|MT0284 from Mycobacterium tuberculosis strain CDC1551 (731 aa), FASTA scores: opt: 1804 [...]
ligB protein networkhttps://string-db.org/network/83332.Rv3062DNA ligase B; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
cstA protein networkhttps://string-db.org/network/83332.Rv3063Probable carbon starvation protein A homolog CstA; Involved in peptide utilization. Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
Rv3064c protein networkhttps://string-db.org/network/83332.Rv3064cRv3064c, (MTCY22D7.17), len: 141 aa. Probable conserved integral membrane protein, similar to many e.g. Q9KY40|SCC8A.08 putative integral membrane protein from Streptomyces coelicolor (153 aa), F [...]
mmr protein networkhttps://string-db.org/network/83332.Rv3065Multidrugs-transport integral membrane protein Mmr; Multidrug efflux pump. Confers resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, pyronin Y a [...]
Rv3066 protein networkhttps://string-db.org/network/83332.Rv3066Rv3066, (MTCY22D7.15c), len: 202 aa. Probable transcriptional regulatory protein deoR-family, with some similarity to transcriptional regulators and hypothetical proteins, e.g. Q9X9V5|SCI7.35c hy [...]
Rv3067 protein networkhttps://string-db.org/network/83332.Rv3067Rv3067, (MTCY22D7.14c), len: 136 aa. Conserved hypothetical protein, weakly similar to other mycobacterium proteins e.g. O53953|Rv1804c|MTV049.26c (108 aa), FASTA scores: opt: 183, E(): 0.00053, [...]
pgmA protein networkhttps://string-db.org/network/83332.Rv3068cRv3068c, (MTCY22D7.13), len: 547 aa. Probable pgmA,phosphoglucomutase, highly similar to other phosphoglucomutases e.g. Q9L117|PGM from Streptomyces coelicolor (546 aa), FASTA scores: opt: 2569, [...]
crcB1 protein networkhttps://string-db.org/network/83332.Rv3069Probable conserved transmembrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
crcB2 protein networkhttps://string-db.org/network/83332.Rv3070Probable conserved integral membrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.
Rv3071 protein networkhttps://string-db.org/network/83332.Rv3071Rv3071, (MTCY22D7.10c), len: 369 aa. Conserved hypothetical protein, weakly similar in N-terminus of Q9A4V0|CC2725 hypothetical protein CC2725 from Caulobacter crescentus (113 aa), FASTA scores: [...]
Rv3072c protein networkhttps://string-db.org/network/83332.Rv3072cRv3072c, (MTCY22D7.09), len: 174 aa. Hypothetical protein, similar in part to O87779 hypothetical 18.1 KDA protein (fragment) from Mycobacterium paratuberculosis (166 aa), FASTA scores: opt: 238, [...]
Rv3073c protein networkhttps://string-db.org/network/83332.Rv3073cRv3073c, (MTCY22D7.08), len: 118 aa. Conserved hypothetical protein, highly similar to other e.g. Q9F3D7|SC2H2.18 from Streptomyces coelicolor (119 aa),FASTA scores: opt: 399, E(): 2.5e-20, (53.0 [...]
Rv3074 protein networkhttps://string-db.org/network/83332.Rv3074Rv3074, (MTCY22D7.07c), len: 424 aa. Conserved hypothetical protein, highly similar but shorter (46 aa) to P71806|Rv1378c|MTCY02B12.12c hypothetical 51.3 KDA protein from Mycobacterium tuberculos [...]
Rv3075c protein networkhttps://string-db.org/network/83332.Rv3075cConserved protein; Rv3075c, (MTCY22D7.06), len: 307 aa. Conserved protein, with some similarity to Q9I562|PA0883 probable acyl-CoA lyase beta chain from Pseudomonas aeruginosa (275 aa), FASTA sco [...]
Rv3076 protein networkhttps://string-db.org/network/83332.Rv3076Rv3076, (MTCY22D7.05c), len: 158 aa. Conserved hypothetical protein, weakly similar to Q9AK12|SC8D11.07 hypothetical 17.0 KDA protein from Streptomyces coelicolor (151 aa), FASTA scores: opt: 110 [...]
Rv3077 protein networkhttps://string-db.org/network/83332.Rv3077Possible hydrolase; Rv3077, (MTCY22D7.04c), len: 603 aa. Possible hydrolase, with some similarity to variety of hydrolases (aryl- and steryl sulfatases principaly) e.g. Q45087|PEHA phosphonate mo [...]
hab protein networkhttps://string-db.org/network/83332.Rv3078Rv3078, (MTCY22D7.03c), len: 133 aa. Probable hab,hydroxylaminobenzene mutase (5.-.-.-) (see Davis et al.,2000), highly similar to two hydroxylaminobenzene mutases from Pseudomonas pseudoalcalige [...]
Rv3079c protein networkhttps://string-db.org/network/83332.Rv3079cConserved protein; Rv3079c, (MTCY22D7.02), len: 275 aa. Conserved protein, similar to other hypothetical mycobacterium proteins e.g. P71557|Y953_MYCTU|Rv0953c|MTCY10D7.21 possible oxidoreductase [...]
pknK protein networkhttps://string-db.org/network/83332.Rv3080cSerine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K); Key microbial factor involved in regulation of early and late events in tuberculosis infection [...]
Rv3081 protein networkhttps://string-db.org/network/83332.Rv3081Rv3081, (MTV013.02), len: 412 aa. Conserved hypothetical protein. Second part of the protein (approximately residues 250-412) shares weak similarity with other hypothetical proteins e.g. Q9YEU3|A [...]
virS protein networkhttps://string-db.org/network/83332.Rv3082cVirulence-regulating transcriptional regulator VirS (AraC/XylS family); Regulates the expression of the mymA operon (Rv3083-Rv3089).
mymA protein networkhttps://string-db.org/network/83332.Rv3083Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding m [...]
lipR protein networkhttps://string-db.org/network/83332.Rv3084Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
sadH protein networkhttps://string-db.org/network/83332.Rv3085Probable short-chain type dehydrogenase/reductase; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH.
adhD protein networkhttps://string-db.org/network/83332.Rv3086Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH [...]
Rv3087 protein networkhttps://string-db.org/network/83332.Rv3087Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH [...]
tgs4 protein networkhttps://string-db.org/network/83332.Rv3088Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acid [...]
fadD13 protein networkhttps://string-db.org/network/83332.Rv3089Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acid [...]
Rv3090 protein networkhttps://string-db.org/network/83332.Rv3090Rv3090, (MTCY164.01), len: 295 aa. Unknown Ala-,Val-rich protein. Hydrophobic stretch at N-terminus.
Rv3091 protein networkhttps://string-db.org/network/83332.Rv3091Conserved protein; Rv3091, (MTCY164.02), len: 563 aa. Conserved protein, similar in part to O60859 neuropathy target esterase from Homo sapiens (Human) (1327 aa), FASTA scores: opt: 177, E(): 0.0 [...]
Rv3092c protein networkhttps://string-db.org/network/83332.Rv3092cRv3092c, (MTCY164.03c), len: 306 aa. Probable conserved integral membrane protein, highly similar to Q9RUT5|DR1297 conserved hypothetical protein from Deinococcus radiodurans (311 aa), FASTA scor [...]
Rv3093c protein networkhttps://string-db.org/network/83332.Rv3093cRv3093c, (MTCY164.04c), len: 334 aa. Hypothetical oxidoreductase, with some similarity with various oxidoreductases e.g. Q58929|mer|MJ1534 N5,N10-methylene tetrahydromethanopterin reductase from [...]
Rv3094c protein networkhttps://string-db.org/network/83332.Rv3094cRv3094c, (MTCY164.05c), len: 376 aa. Conserved hypothetical protein, some similarity with various proteins e.g. Q9RMR9|NRGC NRGC protein (corresponding gene seems regulated by NifA) from Bradyrhi [...]
Rv3095 protein networkhttps://string-db.org/network/83332.Rv3095Rv3095, (MTCY164.06), len: 158 aa. Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from P [...]
Rv3096 protein networkhttps://string-db.org/network/83332.Rv3096Rv3096, (MTCY164.07), len: 379 aa. Hypothetical protein, with slight similarity to several proteins e.g. Q09671|OYEB_SCHPO|SPAC5H10.10 putative NADPH dehydrogenase C5H10.10 (old yellow enzyme hom [...]
lipY protein networkhttps://string-db.org/network/83332.Rv3097cTriacylglycerol lipase; Responsible for the utilization of stored long-chain triacylglycerol (TG) during dormancy and reactivation stage of the infection cycle. Catalyzes the hydrolysis of long-c [...]
Rv3098A protein networkhttps://string-db.org/network/83332.Rv3098APemK-like protein; Putative toxic component of a possible type II toxin- antitoxin (TA) system. Its toxic effect may be neutralized by cognate antitoxin Rv3098B/RVBD_3098B; Belongs to the PemK/Ma [...]
Rv3098c protein networkhttps://string-db.org/network/83332.Rv3098cHypothetical protein; Rv3098c, (MTCY164.09c), len: 150 aa. Hypothetical unknown protein (shorter version of MTCY164.09c). This region is a possible MT-complex-specific genomic island (See Becq et [...]
Rv3099c protein networkhttps://string-db.org/network/83332.Rv3099cConserved protein; Rv3099c, (MTCY164.10c), len: 283 aa. Conserved protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa),FASTA scores: opt: [...]
smpB protein networkhttps://string-db.org/network/83332.Rv3100cProbable SSRA-binding protein SmpB; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with [...]
ftsX protein networkhttps://string-db.org/network/83332.Rv3101cCell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division.
ftsE protein networkhttps://string-db.org/network/83332.Rv3102cCell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. Has ATPase activity.
Rv3103c protein networkhttps://string-db.org/network/83332.Rv3103cHypothetical proline-rich protein; Rv3103c, (MTCY164.13c), len: 145 aa. Hypothetical unknown pro-rich protein, with some similarity to Proline-rich proteins e.g. Q39789 proline-rich cell wall pro [...]
Rv3104c protein networkhttps://string-db.org/network/83332.Rv3104cRv3104c, (MTCY164.14c), len: 308 aa. Possible conserved transmembrane protein, with some similarity to hypthetical proteins e.g. Q9L1X9|SC8E4A.26 putative membrane protein from Streptomyces coeli [...]
prfB protein networkhttps://string-db.org/network/83332.Rv3105cProbable peptide chain release factor 2 PrfB (RF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
fprA protein networkhttps://string-db.org/network/83332.Rv3106NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase); May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 f [...]
agpS protein networkhttps://string-db.org/network/83332.Rv3107cAlkyldihydroxyacetonephosphate synthase AgpS; Rv3107c, (MTCY164.17c), len: 527 aa. Possible agpS,alkyl-dihydroxyacetonephosphate synthase, similar to others and some various enzymes e.g. AAK46595 [...]
Rv3108 protein networkhttps://string-db.org/network/83332.Rv3108Hypothetical protein; Rv3108, (MTCY164.18), len: 146 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
moaA1 protein networkhttps://string-db.org/network/83332.Rv3109Probable molybdenum cofactor biosynthesis protein A MoaA1; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA [...]
moaB1 protein networkhttps://string-db.org/network/83332.Rv31104a-hydroxytetrahydrobiopterin dehydratase; Rv3110, (MTCY164.20), len: 131 aa. Probable moaB1,pterin-4-alpha-carbinolamine dehydratase, similar to others e.g. P73790|SSL2296 from Synechocystis sp. [...]
moaC1 protein networkhttps://string-db.org/network/83332.Rv3111Probable molybdenum cofactor biosynthesis protein C MoaC1; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) (By simila [...]
moaD1 protein networkhttps://string-db.org/network/83332.Rv3112Molybdopterin synthase sulfur carrier subunit; Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin (By similarity). Probably plays a role in host phagosome [...]
Rv3113 protein networkhttps://string-db.org/network/83332.Rv3113Possible phosphatase; Rv3113, (MTCY164.23), len: 222 aa. Possible phosphatase, with weak similarity to other phosphatases e.g. Q9KYY0|SCE33.02c from Streptomyces coelicolor (223 aa), FASTA scores [...]
Rv3114 protein networkhttps://string-db.org/network/83332.Rv3114Rv3114, (MTCY164.24), len: 176 aa. Conserved hypothetical protein, with some similarity to Q9F9W7 cytosine deaminase from Bifidobacterium longum (143 aa),FASTA scores: opt: 207, E(): 2.2e-07, (37 [...]
Rv3115 protein networkhttps://string-db.org/network/83332.Rv3115Probable transposase; Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c,MTCY4 [...]
moeB2 protein networkhttps://string-db.org/network/83332.Rv3116Sulfur-carrier protein adenylyltransferase/sulfurtransferase; Rv3116, (MTCY164.26), len: 389 aa. Probable moeB2,molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 prote [...]
cysA3 protein networkhttps://string-db.org/network/83332.Rv3117Rv3117, (MTCY164.27, MT3199, O05793), len: 277 aa. Probable cysA3 (alternate gene name: sseC3), thiosulfate sulfurtransferase (see Wooff et al., 2002), equivalent to Q50036|CYSA|CYSA3|ML2198|THTR [...]
sseC1 protein networkhttps://string-db.org/network/83332.Rv3118Rv3118, (MTCY164.28, O05794), len: 100 aa. SseC1,conserved hypothetical protein, equivalent to Q9CBC7|ML2199 hypothetical protein from Mycobacterium leprae (100 aa),FASTA scores: opt: 545, E(): 3 [...]
moaE1 protein networkhttps://string-db.org/network/83332.Rv3119Molybdopterin synthase catalytic subunit 1; Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene gr [...]
Rv3120 protein networkhttps://string-db.org/network/83332.Rv3120Rv3120, (MTCY164.30), len: 200 aa. Conserved hypothetical protein, with weak similarity to several hypothetical proteins and many N-methyl transferases e.g. Q9X9V1|ORF8 putative methyltransferase [...]
cyp141 protein networkhttps://string-db.org/network/83332.Rv3121Rv3121, (MTCY164.31), len: 400 aa. Probable cyp141,cytochrome P-450 integral membrane protein, similar to other cytochrome P450-dependent oxidases e.g. Q9X5P9|CYP107N1 from Streptomyces lavendula [...]
Rv3122 protein networkhttps://string-db.org/network/83332.Rv3122Hypothetical protein; Rv3122, (MTCY164.32), len: 156 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv3123 protein networkhttps://string-db.org/network/83332.Rv3123Hypothetical protein; Rv3123, (MTCY164.33), len: 164 aa. Hypothetical unknown protein, but N-terminus shares weak similarity with N-terminal part of O93439|CMESO-1 BHLH transcription factor from [...]
moaR1 protein networkhttps://string-db.org/network/83332.Rv3124Transcriptional regulatory protein MoaR1; Acts as a positive transcriptional regulator of the molybdopterin biosynthesis moa1 locus, promoting the expression of the moaA1B1C1D1 genes. Binds direc [...]
PPE49 protein networkhttps://string-db.org/network/83332.Rv3125cRv3125c, (MTCY164.35c), len: 391 aa. PPE49, Member of the Mycobacterium tuberculosis PPE family, similar to other e.g. P95247|Rv2352c|MTCY98.21c (391 aa), FASTA scores: opt: 1576, E(): 3.8e-72, ( [...]
Rv3126c protein networkhttps://string-db.org/network/83332.Rv3126cHypothetical protein; Rv3126c, (MTCY164.36c), unknown, len: 104 aa. Hypothetical unknown protein. Shortened version of MTCY164.36c, avoiding overlap. This region is a possible MT-complex-specific [...]
Rv3127 protein networkhttps://string-db.org/network/83332.Rv3127Conserved protein; Rv3127, (MTCY164.37), len: 344 aa. Conserved protein, highly similar to Mycobacterium tuberculosis protein O53476|Rv2032|MTV018.19 (331 aa), FASTA scores: opt: 1212, E(): 6e-69 [...]
Rv3128c protein networkhttps://string-db.org/network/83332.Rv3128cRv3128c, (MTCY164.38c), len: 337 aa. Conserved hypothetical protein, similar to other conserved hypothetical proteins. This ORF corresponds to a fusion of MTCY164.38 and MTCY164.39c. Has in-frame [...]
Rv3129 protein networkhttps://string-db.org/network/83332.Rv3129Rv3129, (MTCY164.40), len: 110 aa. Conserved hypothetical protein, with some similarity to various hypothetical proteins from Streptomyces coelicolor e.g. Q9RI34|SCJ12.26 hypothetical 14.5 KDA pr [...]
tgs1 protein networkhttps://string-db.org/network/83332.Rv3130cTriacylglycerol synthase (diacylglycerol acyltransferase) Tgs1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrate [...]
Rv3131 protein networkhttps://string-db.org/network/83332.Rv3131Conserved protein; Stimulates pro-inflammatory cytokine expression via TLR2 signaling pathway. Activation of TLR2 results in the phosphorylation and activation of NF-kappa-B. Also induces TLR2 ex [...]
devS protein networkhttps://string-db.org/network/83332.Rv3132cTwo component sensor histidine kinase DevS; Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. Regulates an approximately 48-member re [...]
devR protein networkhttps://string-db.org/network/83332.Rv3133cTwo component transcriptional regulatory protein DevR (probably LuxR/UhpA-family); Member of the two-component regulatory system DevR/DevS (also called DosR/DosS) involved in onset of the dormanc [...]
Rv3134c protein networkhttps://string-db.org/network/83332.Rv3134cRv3134c, (MTCY03A2.240, len: 268 aa. Universal stress protein family protein. Ala-, Val- rich (see citations below), related to other hypothetical Mycobacterium tuberculosis proteins e.g. O53474| [...]
PPE50 protein networkhttps://string-db.org/network/83332.Rv3135Rv3135, (MTCY03A2.23c), len: 132 aa. PPE50, Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa),FASTA scores: opt: 494, E(): 6.7e-25 [...]
PPE51 protein networkhttps://string-db.org/network/83332.Rv3136Rv3136, (MTCY03A2.22c), len: 380 aa. PPE51, Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to Q9AGF0|Ov2770c Rv2770c-like protein from M. microti (397 aa), FASTA scor [...]
Rv3136A protein networkhttps://string-db.org/network/83332.Rv3136ARv3136A, len: 110 aa. Conserved protein.
hisN protein networkhttps://string-db.org/network/83332.Rv3137Probable monophosphatase; Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine; Belongs to the inositol monophosphatase superfamily.
pflA protein networkhttps://string-db.org/network/83332.Rv3138Rv3138, (MTCY03A2.20c), len: 362 aa. Probable pflA,pyruvate formate lyase activating protein, similar to other e.g. Q9V0N1|PAB1859 from Pyrococcus abyssi (348 aa), FASTA scores: opt: 926, E(): 1. [...]
fadE24 protein networkhttps://string-db.org/network/83332.Rv3139Rv3139, (MTCY03A2.19c), len: 468 aa. Probable fadE24, acyl-CoA dehydrogenase (1.3.99.-), equivalent to O32890|MLCB1779.30|FADE24|ML0661 putative acyl-CoA dehydrogenase from Mycobacterium leprae ( [...]
fadE23 protein networkhttps://string-db.org/network/83332.Rv3140Rv3140, (MTCY03A2.18c), len: 401 aa. Probable fadE23, acyl-CoA dehydrogenase (1.3.99.-) (see citation below), equivalent to O32891|MLCB1779.31|FADE23|ML0660 putative acyl-CoA dehydrogenase from M [...]
fadB4 protein networkhttps://string-db.org/network/83332.Rv3141Rv3141, (MTCY03A2.17c), len: 323 aa. Probable fadB4,quinone oxidoreductase, showing strong similarity to variety of quinone oxidoreductases and domains in polyketide and fatty acid synthases e.g. [...]
Rv3142c protein networkhttps://string-db.org/network/83332.Rv3142cHypothetical protein; Rv3142c, (MTCY03A2.16), len: 142 aa. Hypothetical unknown protein. Equivalent to AAK47569 from Mycobacterium tuberculosis strain CDC1551 but shorter 33 aa.
Rv3143 protein networkhttps://string-db.org/network/83332.Rv3143Rv3143, (MTCY03A2.15c), len: 133 aa. Probable response regulator, similar to other sensory transduction regulatory proteins e.g. Q9X810|SC6G10.25 from Streptomyces coelicolor (133 aa), FASTA scor [...]
PPE52 protein networkhttps://string-db.org/network/83332.Rv3144cRv3144c, (MTCY03A2.14), len: 409 aa. PPE52, Member of the Mycobacterium tuberculosis PPE family, Gly-,Ala-rich, similar to others e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt: 1007 [...]
nuoA protein networkhttps://string-db.org/network/83332.Rv3145Probable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoB protein networkhttps://string-db.org/network/83332.Rv3146Probable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoC protein networkhttps://string-db.org/network/83332.Rv3147Probable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoD protein networkhttps://string-db.org/network/83332.Rv3148Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoE protein networkhttps://string-db.org/network/83332.Rv3149Probable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoF protein networkhttps://string-db.org/network/83332.Rv3150Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoG protein networkhttps://string-db.org/network/83332.Rv3151Probable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoH protein networkhttps://string-db.org/network/83332.Rv3152Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoI protein networkhttps://string-db.org/network/83332.Rv3153Probable NADH dehydrogenase I (chain I) NuoI (NADH-ubiquinone oxidoreductase chain I); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoJ protein networkhttps://string-db.org/network/83332.Rv3154Probable NADH dehydrogenase I (chain J) NuoJ (NADH-ubiquinone oxidoreductase chain J); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoK protein networkhttps://string-db.org/network/83332.Rv3155Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoL protein networkhttps://string-db.org/network/83332.Rv3156Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoM protein networkhttps://string-db.org/network/83332.Rv3157Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
nuoN protein networkhttps://string-db.org/network/83332.Rv3158Probable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory c [...]
PPE53 protein networkhttps://string-db.org/network/83332.Rv3159cRv3159c, (MTV014.03c), len: 590 aa. PPE53, Member of the Mycobacterium tuberculosis PPE_family of Gly-, Asn-rich proteins. Highly similar to P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: opt [...]
Rv3160c protein networkhttps://string-db.org/network/83332.Rv3160cRv3160c, (MTV014.04c), len: 213 aa. Possible transcriptional regulator, with some similarity to others e.g. Q9S3L4|AMTR AMTR protein (global repressor in the nitrogen regulation system; see Jakob [...]
Rv3161c protein networkhttps://string-db.org/network/83332.Rv3161cPossible dioxygenase; Rv3161c, (MTV014.05c), len: 382 aa. Possible dioxygenase, similar to subunit of several dioxygenases and related proteins e.g. BAB50510|MLR3662 dioxygenase, alpha subunit fr [...]
Rv3162c protein networkhttps://string-db.org/network/83332.Rv3162cRv3162c, (MTV014.06c), len: 145 aa. Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis [...]
Rv3163c protein networkhttps://string-db.org/network/83332.Rv3163cRv3163c, (MTV014.07c), len: 423 aa. Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), [...]
moxR3 protein networkhttps://string-db.org/network/83332.Rv3164cRv3164c, (MTV014.08c), len: 320 aa. Probable moxR3,methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c putative regulatory protein from Streptomyces coelicolor (332 aa), [...]
Rv3165c protein networkhttps://string-db.org/network/83332.Rv3165cUnknown protein; Rv3165c, (MTV014.09)c, len: 160 aa. Unknown protein.
Rv3166c protein networkhttps://string-db.org/network/83332.Rv3166cConserved hypothetical protein; Rv3166c, (MTV014.10c), len: 319 aa. Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium lepra [...]
Rv3167c protein networkhttps://string-db.org/network/83332.Rv3167cProbable transcriptional regulatory protein (probably TetR-family); Rv3167c, (MTV014.11c), len: 208 aa. Probable transcriptional regulator, TetR family, similar to several transcriptional regulat [...]
Rv3168 protein networkhttps://string-db.org/network/83332.Rv3168Putative aminoglycoside phosphotransferase; Might catalyze the phosphorylation of aminoglycosides and confer aminoglycoside antibiotics resistance.
Rv3169 protein networkhttps://string-db.org/network/83332.Rv3169Conserved protein; Rv3169, (MTV014.13), len: 374 aa. Conserved protein,with similarity to other hypothetical proteins: Q9A8W6|CC1232 from Caulobacter crescentus (368 aa), FASTA scores: opt: 669, [...]
aofH protein networkhttps://string-db.org/network/83332.Rv3170Rv3170, (MT3259, MTV014.14), len: 448 aa. Probable aofH, flavin-containing (mono)amine oxidase, equivalent to a predicted homologous protein from Mycobacterium smegmatis (see citation below), and [...]
hpx protein networkhttps://string-db.org/network/83332.Rv3171cRv3171c, (MTV014.15c), len: 299 aa. Possible hpx,non-heme haloperoxidase, similar to other hydrolases (principaly epoxide hydrolases) and non-heme chloroperoxidases e.g. Q9RKB6|SCE87.22c putative [...]
Rv3172c protein networkhttps://string-db.org/network/83332.Rv3172cHypothetical protein; Rv3172c, (MTV014.16c), len: 160 aa. Hypothetical unknown protein.
Rv3173c protein networkhttps://string-db.org/network/83332.Rv3173cRv3173c, (MTV014.17c), len: 200 aa. Probable transcriptional regulatory protein TetR family, similar to several bacterial putative regulatory proteins e.g. Q9EWI2|SC7H9.14 from Streptomyces coeli [...]
Rv3174 protein networkhttps://string-db.org/network/83332.Rv3174Rv3174, (MTV014.18), len: 235 aa. Probable oxidoreductase short-chain dehyrogenase/reductase, similar to others e.g. Q9RPT7|sits from Streptomyces albus (223 aa), FASTA scores: opt: 654, E(): 6.1 [...]
Rv3175 protein networkhttps://string-db.org/network/83332.Rv3175Rv3175, (MTV014.19), len: 495 aa. Possible amidase, similar to others e.g. Q9F6D0|ZHUL enantiomer selective amidase from Streptomyces sp. R1128 (507 aa), FASTA scores: opt: 1328, E(): 7.5e-69, (4 [...]
mesT protein networkhttps://string-db.org/network/83332.Rv3176cRv3176c, (MTV014.20c), len: 318 aa. Probable mesT,epoxide hydrolase, similar to others e.g. O15007|PEG1|MEST|Q92571|O14973 MEST protein (mesoderm specific transcript (mouse) homolog) (similar to [...]
Rv3177 protein networkhttps://string-db.org/network/83332.Rv3177Rv3177, (MTV014.21), len: 286 aa. Possible peroxidase (non-haem peroxidase), highly similar to Q9KJF9|W78 cultivar specificity protein (similar to alpha/beta hydrolase fold) W78 from Rhizobium le [...]
Rv3178 protein networkhttps://string-db.org/network/83332.Rv3178Conserved hypothetical protein; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2)-dependent [...]
Rv3179 protein networkhttps://string-db.org/network/83332.Rv3179Conserved protein; Rv3179, (MTV014.23), len: 429 aa. Conserved protein,highly similar to Q9KH61 putative ATP/GTP binding protein from Mycobacterium smegmatis (428 aa), FASTA scores: opt: 2466, E( [...]
vapC49 protein networkhttps://string-db.org/network/83332.Rv3180cHypothetical alanine rich protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB49 (By similarity).
vapB49 protein networkhttps://string-db.org/network/83332.Rv3181cConserved protein; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC49 (Potential).
higB3 protein networkhttps://string-db.org/network/83332.Rv3182Conserved hypothetical protein; Putative toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin would be HigA3. Not toxic upon expression in M.smegmatis.
higA3 protein networkhttps://string-db.org/network/83332.Rv3183Possible transcriptional regulatory protein; Putative antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin would be HigB3.
Rv3184 protein networkhttps://string-db.org/network/83332.Rv3184Rv3184, (MTV014.28), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a [...]
Rv3185 protein networkhttps://string-db.org/network/83332.Rv3185Probable transposase; Rv3185, (MTV014.29), len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be mad [...]
Rv3186 protein networkhttps://string-db.org/network/83332.Rv3186Rv3186, (MTV014.30), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a [...]
Rv3187 protein networkhttps://string-db.org/network/83332.Rv3187Probable transposase; Rv3187, (MTV014.31), len: 328 aa. Probable IS6110 transposase. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be mad [...]
Rv3188 protein networkhttps://string-db.org/network/83332.Rv3188Conserved hypothetical protein; Probable antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the activity of cognate toxin Rv3189 by blocking access to the toxin active site [...]
Rv3189 protein networkhttps://string-db.org/network/83332.Rv3189Conserved hypothetical protein; Probable toxic component of a type II toxin-antitoxin (TA) system. Degrades NAD(+) by phosphorolysis. Neutralized by its cognate antitoxin Rv3188.
Rv3190A protein networkhttps://string-db.org/network/83332.Rv3190ARv3190A, len: 69 aa. Conserved protein.
Rv3190c protein networkhttps://string-db.org/network/83332.Rv3190cHypothetical protein; Rv3190c, (MTV014.34c), len: 421 aa. Hypothetical unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
Rv3191c protein networkhttps://string-db.org/network/83332.Rv3191cProbable transposase; Rv3191c, (MTV014.35c), len: 344 aa. Probable transposase, similar to many especially Q9K2N8 putative transposase from Pseudomonas aeruginosa (338 aa), FASTA scores: opt: 837 [...]
Rv3192 protein networkhttps://string-db.org/network/83332.Rv3192Rv3192, (MTV014.36), len: 153 aa. Conserved hypothetical ala- and pro-rich protein, with weak similarity to N-terminal half of several proteins e.g. Q11030|YD60_MYCTU|Rv1360|MT1405|MTCY02B10.24 h [...]
Rv3193c protein networkhttps://string-db.org/network/83332.Rv3193cRv3193c, (MTV014.37c), len: 992 aa. Probable conserved transmembrane protein, with hydrophobic N-terminal domain (~1-340 aa), highly similar to Q9CCM6|ML0644 putative integral membrane protein fr [...]
Rv3194c protein networkhttps://string-db.org/network/83332.Rv3194cRv3194c, (MTV014.38c), len: 340 aa. Possible conserved secreted protein (N-terminal stretch hydrophobic), equivalent to Q9CCM7|ML0643 putative secreted protein from Mycobacterium leprae (340 aa), [...]
Rv3195 protein networkhttps://string-db.org/network/83332.Rv3195Rv3195, (MTV014.39), len: 472 aa. Hypothetical protein, equivalent to Q49746|ML0642|B1937_C3_231 hypothetical 50.3 KDA protein from Mycobacterium leprae (479 aa), FASTA scores: opt: 2503, E(): 1e [...]
Rv3196 protein networkhttps://string-db.org/network/83332.Rv3196Rv3196, (MTV014.40), len: 299 aa. Hypothetical protein, with some similarity to other hypothetical proteins e.g. Q9FCJ5|2SC3B6.17c putative secreted protein from Streptomyces coelicolor (442 aa), [...]
Rv3196A protein networkhttps://string-db.org/network/83332.Rv3196ARv3196A, len: 66 aa. Unknown protein.
Rv3197 protein networkhttps://string-db.org/network/83332.Rv3197Rv3197, (MTV014.41), len: 447 aa. Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 hypothetical protein (473 aa), FASTA score [...]
whiB7 protein networkhttps://string-db.org/network/83332.Rv3197AProbable transcriptional regulatory protein WhiB-like WhiB7; The apo- but not holo-form probably binds DNA (By similarity). Acts as a transcriptional regulator. Probably redox- responsive. Upon o [...]
Rv3198A protein networkhttps://string-db.org/network/83332.Rv3198ARv3198A, len: 84 aa. Possible glutaredoxin protein, highly similar to Q9FCK1|2SC3B6.11c putative glutaredoxin-like protein from Streptomyces coelicolor (80 aa), FASTA scores: opt: 293, E(): 2.2e- [...]
uvrD2 protein networkhttps://string-db.org/network/83332.Rv3198cProbable ATP-dependent DNA helicase II UvrD2; DNA-dependent ATPase, stimulated equally by ss- and dsDNA. Has both ATPase and helicase activities, and translocates along ssDNA displacing bound str [...]
nudC protein networkhttps://string-db.org/network/83332.Rv3199cNADH pyrophosphatase; Rv3199c, (MTV014.43)c, len: 313 aa. Probable nudC,NADH pyrophosphatase, similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa),FASTA scores: opt: 4 [...]
Rv3200c protein networkhttps://string-db.org/network/83332.Rv3200cRv3200c, (MTV014.44c), len: 355 aa. Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C putative membrane prote [...]
Rv3201c protein networkhttps://string-db.org/network/83332.Rv3201cRv3201c, (MTV014.45c), len: 1101 aa. Probable ATP-dependent DNA helicase, similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa),FASTA scores: opt: 1209, E(): 5.4e-63, (38 [...]
Rv3202c protein networkhttps://string-db.org/network/83332.Rv3202cPossible ATP-dependent DNA helicase; Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase, showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putativ [...]
lipV protein networkhttps://string-db.org/network/83332.Rv3203Possible lipase LipV; Lipase that displays broad substrate specificity and preferentially hydrolyzes p-nitrophenyl myristate in vitro. Also shows significant activity with pNP-butyrate (68%), pNP [...]
Rv3204 protein networkhttps://string-db.org/network/83332.Rv3204Possible DNA-methyltransferase (modification methylase); Rv3204, (MTCY07D11.22c), len: 101 aa. Possible DNA methyltransferase, similar to many hypothetical bacteriel proteins and methyltransferas [...]
Rv3205c protein networkhttps://string-db.org/network/83332.Rv3205cConserved protein; Rv3205c, (MTCY07D11.21), len: 292 aa. Conserved protein, highly similar to Q9CCG7|ML0818 hypothetical protein from Mycobacterium leprae (297 aa), FASTA scores: opt: 1745, E(): [...]
moeB1 protein networkhttps://string-db.org/network/83332.Rv3206cProbable adenylyltransferase/sulfurtransferase MoeZ; Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, A [...]
Rv3207c protein networkhttps://string-db.org/network/83332.Rv3207cConserved protein; Rv3207c, (MTCY07D11.19), len: 285 aa. Conserved protein, highly similar but shorter (57 aa) to Q9CCG9|ML0816 hypothetical protein from Mycobacterium leprae (341 aa), FASTA scor [...]
Rv3208 protein networkhttps://string-db.org/network/83332.Rv3208Probable transcriptional regulatory protein (probably TetR-family); Rv3208, (MTCY07D11.18c), len: 228 aa. Probable transcriptional regulator, TetR family, equivalent to Q9CCH0|ML0815 putative Tet [...]
TB9.4 protein networkhttps://string-db.org/network/83332.Rv3208ARv3208A, len: 90 aa. TB9.4, conserved protein (see citations below), equivalent to Q9CCH1|ML0814 hypothetical protein from Mycobacterium leprae (82 aa), FASTA scores: opt: 411, E(): 1.8e-22, (81. [...]
Rv3209 protein networkhttps://string-db.org/network/83332.Rv3209Rv3209, (MTCY07D11.17c), len: 186 aa. Conserved hypothetical thr-, pro-rich protein, equivalent (but shorter 36 aa in N-terminus) to Q9CCH2|ML0813 putative membrane protein from Mycobacterium lep [...]
Rv3210c protein networkhttps://string-db.org/network/83332.Rv3210cConserved protein; Rv3210c, (MTCY07D11.16), len: 231 aa. Conserved protein, similar (but N-terminus shorter) to Q9FBJ1|SCP8.30 conserved hypothetical protein from Streptomyces coelicolor (260 aa) [...]
rhlE protein networkhttps://string-db.org/network/83332.Rv3211Rv3211, (MTCY07D11.15c), len: 527 aa. Probable rhlE,ATP-dependent RNA helicase, equivalent (but shorter 22 aa) to Q9CCH3|RHLE|ML0811 putative ATP-dependent RNA helicase from Mycobacterium leprae [...]
Rv3212 protein networkhttps://string-db.org/network/83332.Rv3212Rv3212, (MTCY07D11.14c), len: 407 aa. Conserved ala-, val-rich protein, equivalent to Q9CCH4|ML0810 putative membrane protein from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3 [...]
Rv3213c protein networkhttps://string-db.org/network/83332.Rv3213cRv3213c, (MTCY07D11.13), len: 266 aa. Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of spor [...]
gpm2 protein networkhttps://string-db.org/network/83332.Rv3214Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM); Phosphatase with a broad specificity. Can dephosphorylate a variety of substrates including phosphorylate [...]
entC protein networkhttps://string-db.org/network/83332.Rv3215Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis); Catalyzes the conversion of chorismate to isochorismate.
Rv3217c protein networkhttps://string-db.org/network/83332.Rv3217cGCN5-related N-acetyltransferase, pseudogene; Rv3216, (MTCY07D11.10c), len: 160 aa. Acetyltransferase (2.3.1.-), contains GNAT domain (Gcn5-related N-acetyltransferase. See Vetting et al. 2005), [...]
Rv3218 protein networkhttps://string-db.org/network/83332.Rv3218Conserved protein; Rv3218, (MTCY07D11.08c), len: 321 aa. Conserved protein, similar to several hypothetical bacterial proteins e.g. Q9F3M0|2SC7G11.03c from Streptomyces coelicolor (322 aa), FASTA [...]
whiB1 protein networkhttps://string-db.org/network/83332.Rv3219Transcriptional regulatory protein WhiB-like WhiB1. Contains [4FE-4S]2+ cluster; Acts as a transcriptional repressor, inhibiting expression in vitro. Probably redox-responsive. The apo- but not h [...]
pdtaS protein networkhttps://string-db.org/network/83332.Rv3220cProbable two component sensor kinase; Member of the two-component regulatory system PdtaR/PdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to PdtaR.
rshA protein networkhttps://string-db.org/network/83332.Rv3221AAnti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. [...]
TB7.3 protein networkhttps://string-db.org/network/83332.Rv3221cBiotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE [...]
Rv3222c protein networkhttps://string-db.org/network/83332.Rv3222cRv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FAST [...]
sigH protein networkhttps://string-db.org/network/83332.Rv3223cAlternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then rele [...]
Rv3224 protein networkhttps://string-db.org/network/83332.Rv3224Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium [...]
Rv3224A protein networkhttps://string-db.org/network/83332.Rv3224ARv3224A, len: 62 aa. Conserved hypothetical protein (possibly gene fragment), overlaps Rv3224. Similar to N-terminus of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium lepra [...]
Rv3224B protein networkhttps://string-db.org/network/83332.Rv3224BRv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), [...]
Rv3225c protein networkhttps://string-db.org/network/83332.Rv3225cGCN5-related N-acetyltransferase, phosphorylase; Rv3225c, (MTCY07D11.01), len: 474 aa. Conserved hypothetical protein has GNAT (Gcn5-related N-acetyltransferase) domain in N-terminal part (see Ve [...]
Rv3226c protein networkhttps://string-db.org/network/83332.Rv3226cConserved hypothetical protein; Rv3226c, (MTCY20B11.01c), len: 252 aa. Conserved hypothetical protein, similar to various hypothetical bacterial proteins e.g. Q9CCI2|ML0793 putative bacteriophage [...]
aroA protein networkhttps://string-db.org/network/83332.Rv32273-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl [...]
Rv3228 protein networkhttps://string-db.org/network/83332.Rv3228Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May [...]
desA3 protein networkhttps://string-db.org/network/83332.Rv3229cPossible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precu [...]
Rv3230c protein networkhttps://string-db.org/network/83332.Rv3230cHypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membra [...]
Rv3231c protein networkhttps://string-db.org/network/83332.Rv3231cConserved protein; Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 41 [...]
ppk2 protein networkhttps://string-db.org/network/83332.Rv3232cPolyphosphate kinase Ppk2 (polyphosphoric acid kinase); Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP. In addition, modulates nucleotide triphosphate synthesis catalyzed b [...]
Rv3233c protein networkhttps://string-db.org/network/83332.Rv3233cRv3233c, (MTCY20B11.08c), len: 196 aa. Possible triacylglycerol synthase (See Daniel et al., 2004), similar to C-terminus of Q9RIU8|SCM11.13c hypothetical 47.1 KDA protein from Streptomyces coeli [...]
tgs3 protein networkhttps://string-db.org/network/83332.Rv3234cPutative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs3; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as [...]
Rv3235 protein networkhttps://string-db.org/network/83332.Rv3235Rv3235, (MTCY20B11.10), len: 213 aa. Hypothetical unknown ala-, arg-, pro-rich protein.
Rv3236c protein networkhttps://string-db.org/network/83332.Rv3236cRv3236c, (MTCY20B11.11c), len: 385 aa. Probable conserved integral membrane transport protein, possibly cation (Na/H) transporter, equivalent to Q9CCI5|ML0782 putative transmembrane transport pro [...]
Rv3237c protein networkhttps://string-db.org/network/83332.Rv3237cConserved protein; Rv3237c, (MTCY20B11.12c), len: 160 aa. Conserved protein, equivalent to Q9CCI6|ML0781 hypothetical protein from Mycobacterium leprae (160 aa), FASTA scores: opt: 828,E(): 1.5e- [...]
mddA protein networkhttps://string-db.org/network/83332.Rv3238cProbable conserved integral membrane protein; Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).
Rv3239c protein networkhttps://string-db.org/network/83332.Rv3239cRv3239c, (MTCY20B11.14c), len: 1048 aa. Probable conserved transmembrane protein, organised in two domains. Domain comprising first ~500 aa residues is similar to various antibiotic resistance an [...]
secA1 protein networkhttps://string-db.org/network/83332.Rv3240cProbable preprotein translocase SecA1 1 subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysi [...]
hpf protein networkhttps://string-db.org/network/83332.Rv3241cConserved protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential [...]
Rv3242c protein networkhttps://string-db.org/network/83332.Rv3242cConserved hypothetical protein; Rv3242c, (MTCY20B11.17c), len: 213 aa. Conserved hypothetical protein, highly similar in N-terminus to Q9CCI9|ML0776 hypothetical protein from Mycobacterium leprae [...]
Rv3243c protein networkhttps://string-db.org/network/83332.Rv3243cUnknown protein; Rv3243c, (MTCY20B11.18c), len: 280 aa. Unknown protein.
lpqB protein networkhttps://string-db.org/network/83332.Rv3244cProbable conserved lipoprotein LpqB; May modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell division (By similarity). Partially restores antibiotic resista [...]
mtrB protein networkhttps://string-db.org/network/83332.Rv3245cTwo component sensory transduction histidine kinase MtrB; Member of the two-component regulatory system MtrA/MtrB. Probably functions as a membrane-associated protein kinase that phosphorylates M [...]
mtrA protein networkhttps://string-db.org/network/83332.Rv3246cTwo component sensory transduction transcriptional regulatory protein MtrA; Member of the two-component regulatory system MtrA/MtrB. Binds direct repeat motifs of sequence 5'-GTCACAGCG-3', phosph [...]
tmk protein networkhttps://string-db.org/network/83332.Rv3247cThymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK); Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using A [...]
sahH protein networkhttps://string-db.org/network/83332.Rv3248cProbable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Rv3249c protein networkhttps://string-db.org/network/83332.Rv3249cRv3249c, (MTCY20B11.24c), len: 211 aa. Possible transcriptional regulatory protein, TetR family, with similarity to several e.g. Q9AE61|ALKB1 putative TetR-regulatory from Rhodococcus erythropoli [...]
rubB protein networkhttps://string-db.org/network/83332.Rv3250cProbable rubredoxin RubB; Rv3250c, (MTCY20B11.25c), len: 60 aa. Probable rubB,rubredoxin, highly similar to other rubredoxins e.g. Q9AE66|RUBA4 from Rhodococcus erythropolis (60 aa), FASTA scores [...]
rubA protein networkhttps://string-db.org/network/83332.Rv3251cProbable rubredoxin RubA; Rv3251c, (MTCY20B11.26c), len: 55 aa. Probable rubA,rubredoxin, highly similar to other rubredoxins (but sometimes shorter) e.g. Q9AE67|RUBA3 from Rhodococcus erythropol [...]
alkB protein networkhttps://string-db.org/network/83332.Rv3252cRv3252c, (MTCY20B11.27c), len: 416 aa. Probable alkB, transmembrane alkane-1-monooxygenase, highly similar to many (see Marin et al., 2001) e.g. Q9AE68|ALKB2 from Rhodococcus erythropolis (408 aa [...]
Rv3253c protein networkhttps://string-db.org/network/83332.Rv3253cRv3253c, (MTCY20B11.28c), len: 495 aa. Possible cationic amino acid transporter, integral membrane protein,similar to many e.g. O69844|SC1C3.02 putative cationic amino acid transporter from Strep [...]
Rv3254 protein networkhttps://string-db.org/network/83332.Rv3254Rv3254, (MTCY20B11.29), len: 462 aa. Conserved hypothetical protein, similar to CAC37877|SC1G7.02 putative secreted protein from Streptomyces coelicolor (440 aa),FASTA scores: opt: 606, E(): 6.2e [...]
manA protein networkhttps://string-db.org/network/83332.Rv3255cMannose-6-phosphate isomerase ManA; Rv3255c, (MTCY20B11.30c), len: 408 aa. Probable manA, mannose-6-phosphate isomerase, equivalent to Q9CCJ5|MANA|ML0765 putative mannose-6-phosphate isomerase fr [...]
Rv3256c protein networkhttps://string-db.org/network/83332.Rv3256cConserved protein; Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved protein, equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa), FASTA scores: opt: 157 [...]
pmmA protein networkhttps://string-db.org/network/83332.Rv3257cRv3257c, (MTV015.02c), len: 465 aa. Probable pmmA,phosphomannomutase, equivalent to Q9CCJ7|PMMA|ML0763 phosphomannomutase from Mycobacterium leprae (468 aa),FASTA scores: opt: 2533, E(): 2e-145, [...]
Rv3258c protein networkhttps://string-db.org/network/83332.Rv3258cRv3258c, (MTV015.03c), len: 163 aa. Conserved hypothetical protein, equivalent to Q9CCJ8|ML0762 hypothetical protein from Mycobacterium leprae (165 aa),FASTA scores: opt: 840, E(): 9.9e-42, (76.9 [...]
Rv3259 protein networkhttps://string-db.org/network/83332.Rv3259Rv3259, (MTV015.04), len: 139 aa. Conserved hypothetical protein, equivalent, but shorter 29 aa, to Q9CCJ9|ML0761 hypothetical protein from Mycobacterium leprae (167 aa), FASTA scores: opt: 846, [...]
whiB2 protein networkhttps://string-db.org/network/83332.Rv3260cProbable transcriptional regulatory protein WhiB-like WhiB2; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity).
fbiA protein networkhttps://string-db.org/network/83332.Rv3261Probable F420 biosynthesis protein FbiA; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin [...]
fbiB protein networkhttps://string-db.org/network/83332.Rv3262Probable F420 biosynthesis protein FbiB; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-dide [...]
Rv3263 protein networkhttps://string-db.org/network/83332.Rv3263Rv3263, (MTCY71.03), len: 553 aa. Probable DNA methylase, equivalent to Q9CCK4|ML0756 probable DNA methylase from Mycobacterium leprae (555 aa), FASTA scores: opt: 2980, E(): 2.1e-184, (81.9% ide [...]
manB protein networkhttps://string-db.org/network/83332.Rv3264cMannose-1-phosphate guanylyltransferase ManB; Rv3264c, (MTCY71.04c), len: 359 aa. ManB (alternate gene name: hddC), D-alpha-D-mannose-1-phosphate guanylyltransferase (see citations below), equiva [...]
wbbL1 protein networkhttps://string-db.org/network/83332.Rv3265cN-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase; Involved in the biosynthesis of the mycolylarabinogalactan- peptidoglycan (mAGP) complex, an essential component of the mycobacte [...]
rmlD protein networkhttps://string-db.org/network/83332.Rv3266cdTDP-4-dehydrorhamnose reductase; Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects th [...]
Rv3267 protein networkhttps://string-db.org/network/83332.Rv3267Rv3267, (MTCY71.07), len: 498 aa. Conserved protein,CPSA-related protein, equivalent to Q9CCK9|ML0750 hypothetical protein from Mycobacterium leprae (489 aa),FASTA scores: opt: 2523, E(): 5e-138, [...]
Rv3268 protein networkhttps://string-db.org/network/83332.Rv3268Rv3268, (MTCY71.08), len: 229 aa. Conserved hypothetical protein, similar to Q9KZK4|SCE34.22 hypothetical 27.1 KDA protein from Streptomyces coelicolor (263 aa), FASTA scores: opt: 442, E(): 5.9e [...]
Rv3269 protein networkhttps://string-db.org/network/83332.Rv3269Conserved protein; Rv3269, (MTCY71.09), len: 93 aa. Conserved protein,similar to many Mycobacterium proteins and chaperonins/heat shock proteins e.g. Q9CCL0|ML0748 hypothetical protein from Mycob [...]
ctpC protein networkhttps://string-db.org/network/83332.Rv3270Probable metal cation-transporting P-type ATPase C CtpC; High affinity, slow turnover Mn(2+) transporting ATPase, which is required for virulence. Controls the Mn(2+) cytoplasmic quota and is inv [...]
Rv3271c protein networkhttps://string-db.org/network/83332.Rv3271cRv3271c, (MTCY71.11c), len: 222 aa. Probable conserved integral membrane protein, similar to others e.g. Q9RD35|SCM1.07c from Streptomyces coelicolor (230 aa),FASTA scores: opt: 360, E(): 4.7e-16 [...]
Rv3272 protein networkhttps://string-db.org/network/83332.Rv3272Conserved hypothetical protein; Probably involved in fatty acid metabolism. Binds to fatty acyl-CoAs of varying carbon chain lengths, with the highest binding affinity for palmitoyl-CoA (C16:0). [...]
Rv3273 protein networkhttps://string-db.org/network/83332.Rv3273Rv3273, (MTCY71.13), len: 764 aa. Probable transmembrane protein (N-terminal part is hydrophobic) with probable carbonic anhydrase activity (in C-terminal part). Possibly involved in transport of [...]
fadE25 protein networkhttps://string-db.org/network/83332.Rv3274cRv3274c, (MTCY71.14c), len: 389 aa. Probable fadE25,Acyl-CoA Dehydrogenase, equivalent to P46703|ACDP_MYCLE|FADE25|ACD|ML0737|B1308_F1_34 probable acyl-CoA dehydrogenase FADE25 from Mycobacterium [...]
purE protein networkhttps://string-db.org/network/83332.Rv3275cProbable phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AIRC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-ami [...]
purK protein networkhttps://string-db.org/network/83332.Rv3276cProbable phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AIRC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5 [...]
Rv3277 protein networkhttps://string-db.org/network/83332.Rv3277Rv3277, (MTCY71.17), len: 272 aa. Probable conserved transmembrane protein, equivalent, but longer 49 aa, to Q49673|B1308_C1_121|ML0734 putative membrane protein from Mycobacterium leprae (228 aa [...]
Rv3278c protein networkhttps://string-db.org/network/83332.Rv3278cRv3278c, (MTCY71.18c), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CCL2|ML0733 putative membrane protein from Mycobacterium leprae (172 aa), FASTA scores: opt: 1024, E( [...]
birA protein networkhttps://string-db.org/network/83332.Rv3279cBirA protein; Rv3279c, (MTCY71.19c), len: 266 aa. Possible birA,bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase, equivalent to Q9CCL3|BIRA|ML0732 bio [...]
accD5 protein networkhttps://string-db.org/network/83332.Rv3280Rv3280, (MTCY71.20, pccB), len: 548 aa. Probable accD5, propionyl-CoA carboxylase beta chain 5, equivalent to P53002|PCCB_MYCLE|ACCD5|ML0731|B1308_C1_125 probable propionyl-CoA carboxylase beta c [...]
accE5 protein networkhttps://string-db.org/network/83332.Rv3281Rv3281, (MTCY71.21), len: 177 aa. Probable accE5,bifunctional acetyl-/propionyl-coenzyme A carboxylase,epsilon chain, equivalent (but longer 14 aa and with a gap between aa 82-102) to AAK47723|MT [...]
Rv3282 protein networkhttps://string-db.org/network/83332.Rv3282Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nuc [...]
sseA protein networkhttps://string-db.org/network/83332.Rv3283Rv3283, (MTCY71.23), len: 297 aa. Probable sseA,thiosulfate sulfurtransferase, equivalent P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 putative thiosulfate sulfurtransferase SSEA from Mycobacterium [...]
Rv3284 protein networkhttps://string-db.org/network/83332.Rv3284Conserved hypothetical protein; Rv3284, (MTCY71.24, unknown), len: 143 aa. Conserved hypothetical protein, with similarity to other bacterial hypothetical proteins e.g. Q9RXU0|DR0216 from Deinoco [...]
accA3 protein networkhttps://string-db.org/network/83332.Rv3285Rv3285, (MTCY71.25), len: 600 aa. Probable accA3,bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain (see citations below) equivalent to P46392|BCCA_MYCLE|BCCA|ML0726|B1308 [...]
sigF protein networkhttps://string-db.org/network/83332.Rv3286cAlternative RNA polymerase sigma factor SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Held in an ina [...]
rsbW protein networkhttps://string-db.org/network/83332.Rv3287cAnti-sigma factor RsbW (sigma negative effector); A cognate anti-sigma factor for alternative sigma factor SigF. Alternative sigma factors are held in an inactive form by an anti-sigma factor. Bi [...]
usfY protein networkhttps://string-db.org/network/83332.Rv3288cPutative protein UsfY; Rv3288c, (MTCY71.28c), len: 137 aa. UsfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.
Rv3289c protein networkhttps://string-db.org/network/83332.Rv3289cRv3289c, (MTCY71.29c), len: 125 aa. Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins.
lat protein networkhttps://string-db.org/network/83332.Rv3290cRv3290c, (MTCY71.30), len: 449 aa. Probable lat,lysine-epsilon aminotransferase, similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa), FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% id [...]
lrpA protein networkhttps://string-db.org/network/83332.Rv3291cRv3291c, (MTCY71.31c), len: 150 aa. Probable lrpA,transcriptional regulator Lrp/AsnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA [...]
Rv3292 protein networkhttps://string-db.org/network/83332.Rv3292Rv3292, (MTCY71.32), len: 415 aa. Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 hypothetical 51.0 KDA protein from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 74 [...]
pcd protein networkhttps://string-db.org/network/83332.Rv3293Rv3293, (MTCY71.33), len: 494 aa. Probable pcd,piperideine-6-carboxylic acid dehydrogenase, highly similar to others e.g. O85725|PCD semialdehyde dehydrogenase from Streptomyces clavuligerus (512 [...]
Rv3294c protein networkhttps://string-db.org/network/83332.Rv3294cRv3294c, len: 269 aa. Conserved hypothetical protein, similar to several conserved hypothetical proteins from Mycobacterium tuberculosis: O07781|Rv0597c (411 aa),FASTA scores: opt: 682, E(): 3.6e [...]
Rv3295 protein networkhttps://string-db.org/network/83332.Rv3295Probable transcriptional regulatory protein (probably TetR-family); Rv3295, (MTCY71.35), len: 221 aa. Probable transcriptional regulator TetR-family, equivalent to Q9CCL4|ML0717 putative TetR-fam [...]
lhr protein networkhttps://string-db.org/network/83332.Rv3296Rv3296, (MTCY71.36), len: 1513 aa. Probable lhr,ATP-dependent helicase, similar to others e.g. P30015|LHR_ECOLI|RHLF|B1653 from Escherichia coli stain K12 (1538 aa), FASTA scores: opt: 2930, E(): [...]
nei protein networkhttps://string-db.org/network/83332.Rv3297Probable endonuclease VIII Nei; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has AP (apu [...]
lpqC protein networkhttps://string-db.org/network/83332.Rv3298cRv3298c, (MTCY71.38c), len: 304 aa. Possible lpqC,esterase lipoprotein, equivalent to Q9CCL5|LPQC|ML0715 putative secreted hydrolase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1543, E [...]
atsB protein networkhttps://string-db.org/network/83332.Rv3299cRv3299c, (MTCI418A.01c, MTCY71.39c), len: 970 aa. Probable atsB, arylsulfatase, similar to P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from Pseudomonas aeruginosa (535 aa), FASTA scores: o [...]
Rv3300c protein networkhttps://string-db.org/network/83332.Rv3300cRv3300c, (MTCI418A.02c), len: 305 aa. Conserved hypothetical protein, similar to various proteins (notably pseudoridine synthase family proteins) e.g. Q9RJ76|SCI41.08 putative ribosomal pseudouri [...]
phoY1 protein networkhttps://string-db.org/network/83332.Rv3301cProbable phosphate-transport system transcriptional regulatory protein PhoU homolog 1 PhoY1; Plays a role in the regulation of phosphate uptake. In this role, it may bind, possibly as a chaperone [...]
glpD2 protein networkhttps://string-db.org/network/83332.Rv3302cRv3302c, (MTCI418A.04c, MTV016.01c), len: 585 aa. Probable glpd2, glycerol-3-phosphate dehydrogenase,equivalent to P53435|GLPD_MYCLE|ML0713|L308_C1_179 glycerol-3-phosphate dehydrogenase from Myc [...]
lpdA protein networkhttps://string-db.org/network/83332.Rv3303cNAD(P)H quinone reductase LpdA; May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaqu [...]
Rv3304 protein networkhttps://string-db.org/network/83332.Rv3304Conserved protein; Rv3304, (MTV016.03), len: 159 aa. Conserved protein,very similar to Q9CCL6|ML0711 hypothetical protein from Mycobacterium leprae (159 aa), FASTA scores: opt: 1041,E(): 6.1e-62, [...]
amiA1 protein networkhttps://string-db.org/network/83332.Rv3305cRv3305c, (MTV016.04c), len: 389 aa. Possible amiA1,N-acyl-L-amino acid amidohydrolase (or peptidase), similar to many proteins e.g. Q9AK43|2SCK8.09 putative peptidase from Streptomyces coelicolor [...]
amiB1 protein networkhttps://string-db.org/network/83332.Rv3306cRv3306c, (MTV016.05c), len: 394 aa. Probable amiB1,aminohydrolase, similar to several belonging to peptidase family M40 (and to hypothetical proteins) e.g. P54983|AMHX_BACSU amidohydrolase AMHX f [...]
deoD protein networkhttps://string-db.org/network/83332.Rv3307Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP); The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deox [...]
pmmB protein networkhttps://string-db.org/network/83332.Rv3308Rv3308, (MTV016.07), len: 534 aa. Probable pmmB,phosphomannomutase, equivalent to Q9CCL7|PMMB|ML0706 putative phospho-sugar mutase from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681, E() [...]
upp protein networkhttps://string-db.org/network/83332.Rv3309cUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
sapM protein networkhttps://string-db.org/network/83332.Rv3310Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase); Virulence factor that plays an important role in blocking phagosome-lysosome fusion and thus participates i [...]
Rv3311 protein networkhttps://string-db.org/network/83332.Rv3311Conserved protein; Rv3311, (MTV016.10), len: 420 aa. Conserved protein,equivalent to Mycobacterium leprae hypothetical proteins Q9CCL8|ML0703 (423 aa), FASTA scores: opt: 2185, E(): 5.5e-120, (77 [...]
mtp protein networkhttps://string-db.org/network/83332.Rv3312ASecreted protein antigen; Structural subunit of M.tuberculosis pili (MTP), which are thin (2- to 3-nm wide), flexible, coiled-coil, aggregative fibers. Has a strong affinity for laminin but lacks [...]
Rv3312c protein networkhttps://string-db.org/network/83332.Rv3312cRv3312c, (MTV016.11), len: 308 aa. Hypothetical protein, similar to various proteins (principally hypothetical unknowns or hydrolases) e.g. Q9M9P2|T17B22.7 hypothetical protein from Arabidopsis t [...]
add protein networkhttps://string-db.org/network/83332.Rv3313cRv3313c, (MTV016.13), len: 365 aa. Probable add,adenosine deaminase, equivalent to Q9CCL9|add|ML0700 putative adenosine deaminase from Mycobacterium leprae (362 aa), FASTA scores: opt: 2097, E(): [...]
deoA protein networkhttps://string-db.org/network/83332.Rv3314cProbable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase); The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of t [...]
cdd protein networkhttps://string-db.org/network/83332.Rv3315cProbable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase); Recycles cytidine and 2-deoxycytidine for uridine and 2- deoxyuridine synthesis, respectively. Catalyzes [...]
sdhC protein networkhttps://string-db.org/network/83332.Rv3316Succinate dehydrogenase 2 membrane subunit SdhC; Membrane-anchoring subunit of succinate dehydrogenase 2 (Sdh2). Sdh2 may catalyze the two-electron oxidation of succinate to fumarate with a corre [...]
sdhD protein networkhttps://string-db.org/network/83332.Rv3317Rv3317, (MTV016.17), len: 144 aa. Probable sdhD,membrane anchor of succinate dehydrogenase SdhD subunit, equivalent (but shorter 19 aa) to Q49915|SDHD|ML0698|L308_F1_25 putative succinate dehydro [...]
sdhA protein networkhttps://string-db.org/network/83332.Rv3318Rv3318, (MTV016.18), len: 590 aa. Probable sdhA,flavoprotein of succinate dehydrogenase SdhA subunit,equivalent to Q9CCM1|SDHA|ML0697 succinate dehydrogenase flavoprotein subunit from Mycobacteri [...]
sdhB protein networkhttps://string-db.org/network/83332.Rv3319Succinate dehydrogenase / fumarate reductase, iron-sulfur subunit; Rv3319, (MTV016.19), len: 263 aa. Probable sdhB,iron-sulphur protein succinate dehydrogenase SdhB subunit, equivalent to Q49916| [...]
vapC44 protein networkhttps://string-db.org/network/83332.Rv3320cPossible toxin VapC44. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB44 (By similarity).
vapB44 protein networkhttps://string-db.org/network/83332.Rv3321cPossible antitoxin VapB44; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC44.
Rv3322c protein networkhttps://string-db.org/network/83332.Rv3322cPossible methyltransferase; Rv3322c, (MTV016.22c), len: 204 aa. Conserved hypothetical protein, showing weak similarity to proteins including several methyltransferases e.g. Q9X9V1|ORF8 putative [...]
moaX protein networkhttps://string-db.org/network/83332.Rv3323cRv3323c, (MTV016.23c), len: 221 aa. Probable moaX,MoaD-MoaE fusion protein, similar (whole or partial) to several MoaD and MoaE proteins e.g. Q9RR88|DR2607 molybdenum cofactor biosynthesis protei [...]
Rv3324A protein networkhttps://string-db.org/network/83332.Rv3324ARv3324A, len: 44 aa. Probable pseudogene moaB3,fragment of pterin-4-alpha-carbinolamine dehydratase,equivalent to C-terminus of MT3426|Q8VJ32 pterin-4-alpha-carbinolamine dehydratase from Mycobac [...]
moaC3 protein networkhttps://string-db.org/network/83332.Rv3324cProbable molybdenum cofactor biosynthesis protein C 3 MoaC3; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs [...]
Rv3325 protein networkhttps://string-db.org/network/83332.Rv3325Rv3325, (MTV016.25), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a [...]
Rv3326 protein networkhttps://string-db.org/network/83332.Rv3326Probable transposase; Rv3326, (MTV016.26), len: 328 aa. Probable transposase for insertion element IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase des [...]
Rv3327 protein networkhttps://string-db.org/network/83332.Rv3327Rv3327, (MTV016.27), len: 570 aa. Probable fusion protein. Indeed, N-terminal part corresponds to entire O07269 transposase of IS1547 (383 aa), and C-terminal part identical to MTCI249B.03c (210 [...]
sigJ protein networkhttps://string-db.org/network/83332.Rv3328cProbable alternative RNA polymerase sigma factor (fragment) SigJ; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then rele [...]
Rv3329 protein networkhttps://string-db.org/network/83332.Rv3329Probable aminotransferase; Probable aminotransferase.
dacB1 protein networkhttps://string-db.org/network/83332.Rv3330Rv3330, (MTV016.30), len: 405 aa. Probable dacB1,D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein), equivalent to Mycobacterium leprae proteins Q9CCM2|ML0691 putative D-alanyl-D-al [...]
sugI protein networkhttps://string-db.org/network/83332.Rv3331Rv3331, (MTV016.31), len: 502 aa (start uncertain). Probable sugI, sugar-transport integral membrane protein,possibly member of major facilitator superfamily (MFS),similar to several transporters [...]
nagA protein networkhttps://string-db.org/network/83332.Rv3332Rv3332, (MTV016.32), len: 383 aa. Probable nagA,N-acetylglucosamine-6-phosphate deacetylase, similar to many e.g. Q9KXV7|SCD95A.17c putative deacetylase from Streptomyces coelicolor (381 aa), FAS [...]
Rv3333c protein networkhttps://string-db.org/network/83332.Rv3333cRv3333c, (MTV016.33c), len: 281 aa. Hypothetical unknown pro-rich protein. Equivalent to AAK47780 hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (265 aa) but longer 16 aa. Pr [...]
Rv3334 protein networkhttps://string-db.org/network/83332.Rv3334Rv3334, (MTV016.34), len: 146 aa. Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 probable transcriptiona [...]
Rv3335c protein networkhttps://string-db.org/network/83332.Rv3335cRv3335c, (MTV016.35c), len: 289 aa. Probable conserved integral membrane protein, equivalent to Q49909|ML0687 putative membrane protein U0308AA from Mycobacterium leprae (313 aa), FASTA scores: o [...]
trpS protein networkhttps://string-db.org/network/83332.Rv3336cProbable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase); Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA syn [...]
Rv3337 protein networkhttps://string-db.org/network/83332.Rv3337Rv3337, (MTV016.37), len: 128 aa. Conserved hypothetical protein, equivalent to N-terminus of Q49926|ML0685 TPEA (putative hydrolase) from Mycobacterium leprae (303 aa), FASTA scores: opt: 362, E [...]
Rv3338 protein networkhttps://string-db.org/network/83332.Rv3338Rv3338, (MTV016.38), len: 214 aa. Hypothetical protein, equivalent to C-termini of Q49926|ML0685 TPEA (putative hydrolase) from Mycobacterium leprae (303 aa),FASTA scores: opt: 984, E(): 2.6e-56, [...]
icd1 protein networkhttps://string-db.org/network/83332.Rv3339cIsocitrate dehydrogenase [NADP]; Rv3339c, (MTV016.39c), len: 409 aa. Probable icd1,isocitrate dehydrogenase NADP-dependent, highly similar to many e.g. Q9A5C8|CC2522 from Caulobacter crescentus ( [...]
metC protein networkhttps://string-db.org/network/83332.Rv3340O-acetylhomoserine sulfhydrylase MetC; Rv3340, (MTV016.40), len: 449 aa. Probable metC,O-acetyl-L-homoserine sulfhydrylase, highly similar to many e.g. Q9K9P2|BH2603 O-acetylhomoserine sulfhydryl [...]
metA protein networkhttps://string-db.org/network/83332.Rv3341Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Rv3342 protein networkhttps://string-db.org/network/83332.Rv3342Rv3342, (MTV016.42), len: 243 aa. Possible methyltransferase, similar to various proteins e.g. Q9I5X8|PA0558 hypothetical protein from Pseudomonas aeruginosa (255 aa), FASTA scores: opt: 496, E() [...]
PPE54 protein networkhttps://string-db.org/network/83332.Rv3343cPPE family protein PPE54; Probably plays a role in host phagosome maturation arrest.
PE_PGRS49 protein networkhttps://string-db.org/network/83332.Rv3344cPE-PGRS family protein PE_PGRS49; Rv3344c, (MTV016.44c), len: 484 aa. PE_PGRS49,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-, ala-rich proteins (see Brennan and Delo [...]
PE_PGRS50 protein networkhttps://string-db.org/network/83332.Rv3345cPE-PGRS family protein PE_PGRS50; Rv3345c, (MTV004.01c-MTV016.45c), len: 1538 aa. PE_PGRS50, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan a [...]
Rv3346c protein networkhttps://string-db.org/network/83332.Rv3346cRv3346c, (MTV004.02c), len: 85 aa. Conserved transmembrane protein, highly similar to mycobacterium hypothetical proteins O50384|Rv3355c|MTV004.12c from strain H37Rv (97 aa), FASTA scores: opt: 4 [...]
PPE55 protein networkhttps://string-db.org/network/83332.Rv3347cRv3347c, (MTV004.03c), len: 3157 aa. PPE55, Member of the Mycobacterium tuberculosis PPE family, Gly-, Ala-,Asn-rich protein. Similar to many from Mycobacterium tuberculosis strains H37Rv and CDC [...]
Rv3348 protein networkhttps://string-db.org/network/83332.Rv3348Probable transposase; Rv3348, (MTV004.04), len: 163 aa. Probable transposase, partially similar to several insertion elements e.g. P19834|YI11_STRCL insertion element IS116 hypothetical 44.8 KDA [...]
Rv3349c protein networkhttps://string-db.org/network/83332.Rv3349cProbable transposase; Rv3349c, (MTV004.05c), len: 246 aa. Probable transposase pseudogene fragment, similar to part of Q50911|U10634 IS204 putative transposase from nocardia asteroides (377 aa), [...]
PPE56 protein networkhttps://string-db.org/network/83332.Rv3350cRv3350c, (MTV004.07c), len: 3716 aa. PPE56, Member of the Mycobacterium tuberculosis PPE family of Gly-, Ala-,Asn-rich proteins, similar to many Mycobacterium tuberculosis proteins from strains H [...]
Rv3351c protein networkhttps://string-db.org/network/83332.Rv3351cRv3351c, (MTV004.08c), len: 264 aa. Hypothetical protein, highly similar to C-terminal region (aa 292-479) of O53608|Rv0063|MTV030.06 oxidoreductase from Mycobacterium tuberculosis (479 aa), FAST [...]
Rv3352c protein networkhttps://string-db.org/network/83332.Rv3352cRv3352c, (MTV004.09c), len: 123 aa. Possible oxidoreductase, similar to part of several oxidoreductases (and hypothetical proteins) from diverse organisms e.g. Q9KYD6|SCD72A.20 putative lipoprote [...]
Rv3353c protein networkhttps://string-db.org/network/83332.Rv3353cRv3353c, (MTV004.10c), len: 86 aa. Hypothetical protein, showing some similarity to Q9X5Q4|MITR MITR protein from Streptomyces lavendulae (514 aa), FASTA scores: opt: 134, E(): 0.09, (29.5% ident [...]
Rv3354 protein networkhttps://string-db.org/network/83332.Rv3354Rv3354, (MTV004.11), len: 129 aa. Conserved hypothetical protein, equivalent (but shorter 29 aa) to Q9CCM4|ML0676 hypothetical protein from Mycobacterium leprae (158 aa), FASTA scores: opt: 467, [...]
Rv3355c protein networkhttps://string-db.org/network/83332.Rv3355cRv3355c, (MTV004.12c), len: 97 aa. Probable integral membrane protein, equivalent to O32878|MLCB1779.16c|ML0675 hypothetical 9.6 KDA protein from Mycobacterium leprae (91 aa), FASTA scores: opt: [...]
folD protein networkhttps://string-db.org/network/83332.Rv3356cMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10 [...]
relJ protein networkhttps://string-db.org/network/83332.Rv3357Antitoxin RelJ; Antitoxin component of a type II toxin-antitoxin (TA) system. A probable antitoxin for the putative mRNA interferase RelK. Upon expression in E.coli but not in M.smegmatis this pr [...]
relK protein networkhttps://string-db.org/network/83332.Rv3358Toxin RelK; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity and preferentially cleaves at the 3'-end of purine ribonucleotides (By similarity). Overexpression in M.tu [...]
Rv3359 protein networkhttps://string-db.org/network/83332.Rv3359Rv3359, (MTV004.16), len: 396 aa. Possible oxidoreductase, similar to N-terminal part of various proteins (hypothetical unknowns or oxidoreductases) e.g. Q9ZB94 hypothetical 69.3 KDA protein from [...]
Rv3360 protein networkhttps://string-db.org/network/83332.Rv3360Rv3360, (MTV004.17), len: 122 aa. Hypothetical protein, highly similar to the N-terminus of O65934|Rv1747|MTCY28.10|MTCY04C12.31 probable ABC-transporter ATP-binding protein from Mycobacterium tu [...]
mfpA protein networkhttps://string-db.org/network/83332.Rv3361cConserved protein; Might be involved in fluoroquinolone resistance. Inhibits ATP-independent DNA relaxation, ATP- dependent DNA supercoiling and ATP-dependent decatenation by endogenous gyrase, 5 [...]
Rv3362c protein networkhttps://string-db.org/network/83332.Rv3362cRv3362c, (MTV004.19c), len: 193 aa. Probable ATP/GTP-binding protein, similar to others from Streptomyces coelicolor e.g. O86519|SC1C2.18c (174 aa),FASTA scores: opt: 731, E(): 9.8e-41, (66.85% i [...]
Rv3363c protein networkhttps://string-db.org/network/83332.Rv3363cRv3363c, (MTV004.20c), len: 122 aa. Conserved hypothetical protein, similar to others from Streptomyces coelicolor e.g. O86523|SC1C2.23c (132 aa), FASTA scores: opt: 236, E(): 9e-09, (38.5% ident [...]
Rv3364c protein networkhttps://string-db.org/network/83332.Rv3364cConserved protein; Effector protein that binds to the host serine protease cathepsin G on the macrophage cell membrane, inhibiting its enzymatic activity and the downstream activation of caspase- [...]
Rv3365c protein networkhttps://string-db.org/network/83332.Rv3365cConserved protein; Rv3365c, (MTV004.22c), len: 876 aa. Conserved protein, similar to various proteins from Streptomyces coelicolor e.g. O86525|SC1C2.25c hypothetical 139.7 KDA protein (similar to [...]
spoU protein networkhttps://string-db.org/network/83332.Rv3366Probable tRNA/rRNA methylase SpoU (tRNA/rRNA methyltransferase); Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferas [...]
PE_PGRS51 protein networkhttps://string-db.org/network/83332.Rv3367PE-PGRS family protein PE_PGRS51; Rv3367, (MTV004.25), len: 588 aa. PE_PGRS51, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002). [...]
Rv3368c protein networkhttps://string-db.org/network/83332.Rv3368cRv3368c, (MTV004.26c), len: 214 aa. Possible oxidoreductase, equivalent to O07697|MLCL383.23|ML0418 hypothetical 23.6 KDA protein (putative oxidoreductase) from Mycobacterium leprae (210 aa), FAS [...]
Rv3369 protein networkhttps://string-db.org/network/83332.Rv3369Conserved protein; Rv3369, (MTV004.27), len: 144 aa. Conserved protein. C-terminus is similar to N-terminus of O07696|MLCL383.22c hypothetical 14.7 KDA protein from Mycobacterium leprae (131 aa), [...]
dnaE2 protein networkhttps://string-db.org/network/83332.Rv3370cProbable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase); DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicativ [...]
Rv3371 protein networkhttps://string-db.org/network/83332.Rv3371Possible triacylglycerol synthase (diacylglycerol acyltransferase); Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as subst [...]
otsB2 protein networkhttps://string-db.org/network/83332.Rv3372Trehalose 6-phosphate phosphatase OtsB2 (trehalose-phosphatase) (TPP); Removes the phosphate from trehalose 6-phosphate to produce free trehalose.
echA18 protein networkhttps://string-db.org/network/83332.Rv3373Probable enoyl-CoA hydratase EchA18 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv3373, (MTV004.31), len: 213 aa. Probable echA18,enoyl-CoA hydratase, similar to others e.g. P97 [...]
echA18.1 protein networkhttps://string-db.org/network/83332.Rv3374Probable enoyl-CoA hydratase EchA18.1 (Enoyl hydrase) (Unsaturated acyl-CoA hydratase) (Crotonase); Rv3374, (MTV004.32), len: 82 aa. Probable echA18.1,enoyl-CoA hydratase C-terminus, similar to t [...]
amiD protein networkhttps://string-db.org/network/83332.Rv3375Rv3375, (MTV004.33), len: 475 aa. Probable amiD,amidase, similar to various amidases e.g. Q53116|AMDA enantiomerase-selective amidase from Rhodococcus sp. (462 aa), FASTA scores: opt: 1036, E(): [...]
Rv3376 protein networkhttps://string-db.org/network/83332.Rv3376Conserved hypothetical protein; Able to hydrolyze geranyl diphosphate (GPP), farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) to respectively yield geraniol, farnesol and geranylg [...]
Rv3377c protein networkhttps://string-db.org/network/83332.Rv3377cHalimadienyl diphosphate synthase; Catalyzes the formation of tuberculosinyl diphosphate from geranylgeranyl diphosphate (GGPP). It could also react with (14R/S)- 14,15-oxidoGGPP to generate 3alp [...]
Rv3378c protein networkhttps://string-db.org/network/83332.Rv3378cDiterpene synthase; Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1- tuberculosinyladenosine (1-TbAd), which acts as an [...]
dxs2 protein networkhttps://string-db.org/network/83332.Rv3379c1-deoxy-D-xylulose-5-phosphate synthase Dxs2; Rv3379c, (MTV004.37c), len: 536 aa. Probable dxs2,1-deoxy-D-xylulose 5-phosphate synthase, similar to many e.g. Q9F1V2|DXS from Kitasatospora griseol [...]
Rv3380c protein networkhttps://string-db.org/network/83332.Rv3380cProbable transposase; Rv3380c, (MTV004.38c), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described h [...]
Rv3381c protein networkhttps://string-db.org/network/83332.Rv3381cRv3381c, (MTV004.39c), len: 108 aa. Putative Transposase for IS6110 (fragment). Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by [...]
lytB1 protein networkhttps://string-db.org/network/83332.Rv3382cProbable LYTB-related protein LytB1; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphospha [...]
idsB protein networkhttps://string-db.org/network/83332.Rv3383cRv3383c, (MTV004.41c), len: 350 aa. Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR geran [...]
vapC46 protein networkhttps://string-db.org/network/83332.Rv3384cPossible toxin VapC46. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic [...]
vapB46 protein networkhttps://string-db.org/network/83332.Rv3385cPossible antitoxin VapB46; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC46.
Rv3386 protein networkhttps://string-db.org/network/83332.Rv3386Possible transposase; Rv3386, (MTV004.44), len: 234 aa. Possible transposase, showing very weak similarity to several is element transposases. Highly similar (but shorter) to P963659|MTCY10G2_13| [...]
Rv3387 protein networkhttps://string-db.org/network/83332.Rv3387Possible transposase; Rv3387, (MTV004.45), len: 225 aa. Possible transposase, showing very weak similarity to other is element proteins, and similar to various hypothetical proteins.
PE_PGRS52 protein networkhttps://string-db.org/network/83332.Rv3388PE-PGRS family protein PE_PGRS52; Rv3388, (MTV004.46), len: 731 aa. PE_PGRS52, Member of the M. tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), similar to many P [...]
htdY protein networkhttps://string-db.org/network/83332.Rv3389cProbable 3-hydroxyacyl-thioester dehydratase HtdY; Shows trans-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydratase activity. In vitro, can hydrate various enoyl-CoA such as (2E)-hexenoyl-CoA, (2E)- [...]
lpqD protein networkhttps://string-db.org/network/83332.Rv3390Rv3390, (MTV004.48), len: 236 aa. Probable lpqD, a conserved lipoprotein with some similarity to various bacterial proteins e.g. Q9F3Q7|SC10F4.03 putative isomerase from Streptomyces coelicolor ( [...]
acrA1 protein networkhttps://string-db.org/network/83332.Rv3391Rv3391, (MTV004.49), len: 650 aa. Possible acrA1,multi functional protein with fatty acyl-CoA reductase activity in C-terminal part. Indeed C-terminal part highly similar to P94129|ACR1 fatty acy [...]
cmaA1 protein networkhttps://string-db.org/network/83332.Rv3392cCyclopropane mycolic acid synthase 1; Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S [...]
iunH protein networkhttps://string-db.org/network/83332.Rv3393Rv3393, (MTV004.51), len: 308 aa. Probable iunH,nucleoside hydrolase, similar to others e.g. Q9RXB2|DR0403 from Deinococcus radiodurans (314 aa), FASTA scores: opt: 497, E(): 6e-24, (34.3% identi [...]
Rv3394c protein networkhttps://string-db.org/network/83332.Rv3394cRv3394c, (MTV004.52c), len: 527 aa. Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (5 [...]
Rv3395A protein networkhttps://string-db.org/network/83332.Rv3395ARv3395A, len: 208 aa. Probable membrane protein,with potential transmembrane stretches from aa 7..25 and 55..77. Weak similarity to Q9F2P3|SCE41.16C putative lipoprotein from Streptomyces coelico [...]
Rv3395c protein networkhttps://string-db.org/network/83332.Rv3395cRv3395c, (MTCY78.33), len: 204 aa. Conserved hypothetical protein, with some similarity with RECA proteins (recombinases A) e.g. P16238|RECA_THIFE from Thiobacillus ferrooxidans (346 aa), FASTA s [...]
guaA protein networkhttps://string-db.org/network/83332.Rv3396cProbable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP.
phyA protein networkhttps://string-db.org/network/83332.Rv3397cProbable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPP [...]
idsA1 protein networkhttps://string-db.org/network/83332.Rv3398c(2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used fo [...]
Rv3399 protein networkhttps://string-db.org/network/83332.Rv3399Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv3400 protein networkhttps://string-db.org/network/83332.Rv3400Probable hydrolase; Rv3400, (MTCY78.28c), len: 262 aa. Probable hydrolase, strongly equivalent to Q49741|YY00_MYCLE|ML0393|B1620_F3_119 hypothetical 28.6 KDA protein from Mycobacterium leprae (26 [...]
Rv3401 protein networkhttps://string-db.org/network/83332.Rv3401Conserved protein; Rv3401, (MTCY78.27c), len: 786 aa. Conserved protein, may be an hydrolase or a transferase, equivalent to Q49736|ML0392|B1620_F1_30 hypothetical 88.1 KDA protein from Mycobacte [...]
Rv3402c protein networkhttps://string-db.org/network/83332.Rv3402cRv3402c, (MTCY78.26), len: 412 aa. Conserved hypothetical protein, probably involved in cell process,similar to various proteins generally involved in extracellular compounds (lipopolysaccharide [...]
Rv3403c protein networkhttps://string-db.org/network/83332.Rv3403cHypothetical protein; Rv3403c, (MTCY78.25), len: 533 aa. Hypothetical unknown protein, but some weak similarity to Q9KJP2 hypothetical 54.9 KDA protein from Myxococcus xanthus (504 aa), FASTA sco [...]
Rv3404c protein networkhttps://string-db.org/network/83332.Rv3404cConserved hypothetical protein; Sugar N-formyltransferase that catalyzes the conversion of dTDP-4-amino-4,6-dideoxyglucose into dTDP-4-formamido-4,6- dideoxyglucose using N(10)-formyltetrahydrofo [...]
Rv3405c protein networkhttps://string-db.org/network/83332.Rv3405cPossible transcriptional regulatory protein; Negatively regulates the expression of sulfate ester dioxygenase Rv3406 and its own expression. Binds specifically to the inverted repeat sequence of [...]
Rv3406 protein networkhttps://string-db.org/network/83332.Rv3406Probable dioxygenase; Alpha-ketoglutarate-dependent sulfate ester dioxygenase, which oxidizes medium-chain alkyl-sulfate esters. Shows preference for 2-ethylhexyl sulfate (2-EHS) in vitro, leadin [...]
vapB47 protein networkhttps://string-db.org/network/83332.Rv3407Possible antitoxin VapB47; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC47.
vapC47 protein networkhttps://string-db.org/network/83332.Rv3408Possible toxin VapC47. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits translation and colony form [...]
choD protein networkhttps://string-db.org/network/83332.Rv3409cCholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol [...]
guaB3 protein networkhttps://string-db.org/network/83332.Rv3410cUncharacterized oxidoreductase Rv3410c; Has no inosine-5'-monophosphate dehydrogenase activity. Belongs to the IMPDH/GMPR family.
guaB2 protein networkhttps://string-db.org/network/83332.Rv3411cInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesi [...]
Rv3412 protein networkhttps://string-db.org/network/83332.Rv3412Rv3412, (MTCY78.16c), len: 136 aa. Hypothetical protein, strongly similar to Q49742|YY12_MYCLE|ML0386|B1620_F3_131 hypothetical 15.3 KDA protein from Mycobacterium leprae (137 aa), FASTA scores: [...]
rsdA protein networkhttps://string-db.org/network/83332.Rv3413cUnknown alanine and proline rich protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigD. ECF sigma factors are held in an inactive form by an anti-sigma factor until [...]
sigD protein networkhttps://string-db.org/network/83332.Rv3414cProbable alternative RNA polymerase sigma-D factor SigD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Ext [...]
Rv3415c protein networkhttps://string-db.org/network/83332.Rv3415cRv3415c, (MTCY78.14), len: 275 aa. Conserved hypothetical protein, equivalent to Q9CCV3|ML0383 hypothetical protein from Mycobacterium leprae (281 aa),FASTA scores: opt: 1278, E(): 4.2e-71, (73.5 [...]
whiB3 protein networkhttps://string-db.org/network/83332.Rv3416Transcriptional regulatory protein WhiB-like WhiB3. Contains [4FE-4S] cluster; A redox-sensitive transcriptional regulator. Maintains intracellular redox homeostasis by regulating catabolic metab [...]
groEL1 protein networkhttps://string-db.org/network/83332.Rv3417c60 kDa chaperonin 1 GroEL1 (protein CPN60-1) (GroEL protein 1); Prevents aggregation of substrate proteins and promotes their refolding. Functions in the absence of co-chaperone CH10 and ATP.
groES protein networkhttps://string-db.org/network/83332.Rv3418c10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Bel [...]
gcp protein networkhttps://string-db.org/network/83332.Rv3419cProbable O-sialoglycoprotein endopeptidase Gcp (glycoprotease); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning w [...]
rimI protein networkhttps://string-db.org/network/83332.Rv3420cN-alpha-acetyltransferase RimI; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues. Able to mediate acetylation of a wide variety of N-terminal residues, [...]
Rv3421c protein networkhttps://string-db.org/network/83332.Rv3421cRv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA score [...]
tsaE protein networkhttps://string-db.org/network/83332.Rv3422cConserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the [...]
alr protein networkhttps://string-db.org/network/83332.Rv3423cAlanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking.
Rv3424c protein networkhttps://string-db.org/network/83332.Rv3424cHypothetical protein; Rv3424c, (MTCY78.05), len: 120 aa. Hypothetical unknown protein.
PPE57 protein networkhttps://string-db.org/network/83332.Rv3425PPE family protein PPE57; Plays a key role in regulating innate and adaptive immune responses through human Toll-like receptor 2 (TLR2). Interacts with TLR2, leading to the subsequent activation [...]
PPE58 protein networkhttps://string-db.org/network/83332.Rv3426Rv3426, (MTCY78.03c), len: 232 aa. PPE58, Member of the M. tuberculosis PPE family, similar to many e.g. the downstream O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 555, E(): 6.5e-26, (72 [...]
Rv3427c protein networkhttps://string-db.org/network/83332.Rv3427cPossible transposase; Rv3427c, (MTCY78.02), len: 251 aa. Possible transposase, similar to other e.g. Q9APG8|ORF2 putative transposase subunit 2 from Pseudomonas putida (251 aa),FASTA scores: opt: [...]
Rv3428c protein networkhttps://string-db.org/network/83332.Rv3428cPossible transposase; Rv3428c, (MTCY78.01, len: 410 aa. Possible transposase insertion sequence, similar to others e.g. Q9APG9|ORF1 from Pseudomonas putida (509 aa), FASTA scores: opt: 578, E(): [...]
PPE59 protein networkhttps://string-db.org/network/83332.Rv3429Rv3429, (MTCY77.01), len: 178 aa. PPE59, Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa),FASTA scores: opt: 781, E(): 1.9e [...]
Rv3430c protein networkhttps://string-db.org/network/83332.Rv3430cPossible transposase; Rv3430c, (MTCY77.02c), len: 387 aa. Possible IS1540 transposase, similar to several e.g. Q49592 transposase from Mycobacterium intracellulare (340 aa), FASTA scores: opt: 13 [...]
Rv3431c protein networkhttps://string-db.org/network/83332.Rv3431cPossible transposase (fragment); Required for the transposition of the insertion element.
gadB protein networkhttps://string-db.org/network/83332.Rv3432cRv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6 [...]
nnr protein networkhttps://string-db.org/network/83332.Rv3433cConserved protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted t [...]
Rv3434c protein networkhttps://string-db.org/network/83332.Rv3434cRv3434c, (MTCY77.06c), len: 237 aa. Possible conserved transmembrane protein, showing some similarity with Q9CGH7|YLDB hypothetical protein from Lactococcus lactis (subsp. lactis) (Streptococcus [...]
Rv3435c protein networkhttps://string-db.org/network/83332.Rv3435cRv3435c, (MTCY77.07c), len: 284 aa. Probable conserved transmembrane protein, showing some similarity with P95061|Rv0713|MTCY210.32 hypothetical 33.9 KDA protein from Mycobacterium tuberculosis ( [...]
glmS protein networkhttps://string-db.org/network/83332.Rv3436cGlutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Rv3437 protein networkhttps://string-db.org/network/83332.Rv3437Rv3437, (MTCY77.09), len: 158 aa. Questionable ORF. Possible conserved transmenbrane protein, C-terminus similar to N-terminal part of O06345|Rv3482c|MTCY13E12.35c hypothetical 28.5 KDA protein f [...]
Rv3438 protein networkhttps://string-db.org/network/83332.Rv3438Conserved protein; Rv3438, (MTCY77.10), len: 280 aa. Conserved protein,equivalent to Q9CCV6|ML0370 hypothetical protein from Mycobacterium leprae (289 aa), FASTA scores: opt: 1491,E(): 9.2e-81, ( [...]
Rv3439c protein networkhttps://string-db.org/network/83332.Rv3439cRv3439c, (MTCY77.11c), len: 467 aa. Conserved hypothetical ala-, pro-rich protein, similar in part to N-terminal part of Q49853|B229_C1_154 hypothetical 11.2 KDA protein from Mycobacterium leprae [...]
Rv3440c protein networkhttps://string-db.org/network/83332.Rv3440cHypothetical protein; Rv3440c, (MTCY77.12c), len: 103 aa. Hypothetical unknown protein.
mrsA protein networkhttps://string-db.org/network/83332.Rv3441cProbable phospho-sugar mutase / MrsA protein homolog; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
rpsI protein networkhttps://string-db.org/network/83332.Rv3442cRv3442c, (MTCY77.14c), len: 151 aa. rpsI, 30S ribosomal protein S9, equivalent to P40828|RS9_MYCLE|ML0365|B229_C2_191 30S ribosomal protein S9 (153 aa), FASTA scores: opt: 800, E(): 2.1e-42, (83. [...]
rplM protein networkhttps://string-db.org/network/83332.Rv3443c50S ribosomal protein L13 RplM; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early s [...]
esxT protein networkhttps://string-db.org/network/83332.Rv3444cPutative ESAT-6 like protein EsxT; Induces apoptosis of host cells via activation of NF-kappa-B.
esxU protein networkhttps://string-db.org/network/83332.Rv3445cRv3445c, (MTCY77.17c), len: 105 aa. EsxU, ESAT-6 like protein (see citations below), showing weak similarity to O30373|VCD|PA2257 pyoverdine biosynthesis protein from Pseudomonas aeruginosa (215 [...]
Rv3446c protein networkhttps://string-db.org/network/83332.Rv3446cRv3446c, (MTCY77.18c), len: 404 aa. Hypothetical unknown ala-, val-rich protein.
eccC4 protein networkhttps://string-db.org/network/83332.Rv3447cRv3447c, (MTCY77.19c), len: 1236 aa. EccC4, esx conserved component, ESX-4 type VII secretion system protein, probable membrane protein, similar to various bacterial proteins e.g. O86653|SC3C3.20 [...]
eccD4 protein networkhttps://string-db.org/network/83332.Rv3448ESX-4 secretion system protein eccD4; Rv3448, (MTCY77.20), len: 467 aa. EccD4, esx conserved component, ESX-4 type VII secretion system protein, probable integral membrane protein, showing some s [...]
mycP4 protein networkhttps://string-db.org/network/83332.Rv3449Mycosin-4; Rv3449, (MTCY13E12.02), len: 455 aa. Probable mycP4,membrane-anchored serine protease (mycosin) (see citation below), similar to hypothetical unknowns or proteases from Mycobacterium t [...]
eccB4 protein networkhttps://string-db.org/network/83332.Rv3450cESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity).
cut3 protein networkhttps://string-db.org/network/83332.Rv3451Rv3451, (MTCY13E12.04), len: 262 aa. Probable cut3,cutinase precursor, similar to others e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 540, E(): 3.5e-24, (43.4% identity in 21 [...]
cut4 protein networkhttps://string-db.org/network/83332.Rv3452Rv3452, (MTCY13E12.05), len: 226 aa. Probable cut4,cutinase precursor, similar to other e.g. Q9KK87 from Mycobacterium avium (220 aa), FASTA scores: opt: 522, E(): 7.3e-24, (46.6% identity in 221 [...]
Rv3453 protein networkhttps://string-db.org/network/83332.Rv3453Rv3453, (MTCY13E12.06), len: 110 aa. Possible conserved transmembrane protein, showing weak similarity with other proteins e.g. Q9F6C3 putative ABC transporter from Propionibacterium thoenii (424 [...]
Rv3454 protein networkhttps://string-db.org/network/83332.Rv3454Rv3454, (MTCY13E12.07), len: 422 aa. Probable conserved integral membrane protein, showing some similarity to various proteins (generally transporters) e.g. Q9I5C8|PA0811 probable MFS transporter [...]
truA protein networkhttps://string-db.org/network/83332.Rv3455ctRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
rplQ protein networkhttps://string-db.org/network/83332.Rv3456cRv3456c, (MTCY13E12.09c), len: 180 aa. rplQ, 50S ribosomal protein L17, equivalent to Q9X797|RL17_MYCLE|ML1956|MLCB1222.26c 50S ribosomal protein L17 from Mycobacterium leprae (170 aa), FASTA sco [...]
rpoA protein networkhttps://string-db.org/network/83332.Rv3457cDNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rpsD protein networkhttps://string-db.org/network/83332.Rv3458c30S ribosomal protein S4 RpsD; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Belongs to the universal ribosom [...]
rpsK protein networkhttps://string-db.org/network/83332.Rv3459c30S ribosomal protein S11 RpsK; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; [...]
rpsM protein networkhttps://string-db.org/network/83332.Rv3460c30S ribosomal protein S13 RpsM; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and prote [...]
rpmJ protein networkhttps://string-db.org/network/83332.Rv3461cRv3461c, (MTCY13E12.14c), len: 37 aa. rpmJ, 50S ribosomal protein L36, equivalent to P45810|RL36_MYCBO|RPMJ from Mycobacterium bovis (37 aa); and Q9X7A2|RL36_MYCLE|RPMJ|ML1961|MLCB1222.31c 50S ri [...]
infA protein networkhttps://string-db.org/network/83332.Rv3462cProbable translation initiation factor if-1 InfA; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-fo [...]
Rv3463 protein networkhttps://string-db.org/network/83332.Rv3463Conserved protein; Rv3463, (MTCY13E12.16), len: 285 aa. Conserved protein, similar to Q9RDA2|SCE20.23 hypothetical 31.4 KDA protein from Streptomyces coelicolor (290 aa), FASTA scores: opt: 770, [...]
rmlB protein networkhttps://string-db.org/network/83332.Rv3464dTDP-glucose 4,6-dehydratase RmlB; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By [...]
rmlC protein networkhttps://string-db.org/network/83332.Rv3465dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Involved in the biosynthes [...]
Rv3466 protein networkhttps://string-db.org/network/83332.Rv3466Rv3466, (MTCY13E12.19), len: 222 aa. Conserved hypothetical ORF in REP13E12 repeat, but extending 5' of repeat. Has segment of identity to other REP13E12 ORF's e.g. MTCY336.16, MTCI65.15c, MTCY09 [...]
Rv3467 protein networkhttps://string-db.org/network/83332.Rv3467Rv3467, (MTCY13E12.20), len: 317 aa. Conserved hypothetical ORF in REP13E12 repeat, identical to ORF's from other REP13E12 copies e.g. MTCY251.13c, MTCI65.15c,MTCY09F9.19, cMTCY336.17. Also ident [...]
Rv3468c protein networkhttps://string-db.org/network/83332.Rv3468cRv3468c, (MTCY13E12.21c), len: 364 aa. Possible dTDP-glucose-4,6-dehydratase, but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see Ma e [...]
mhpE protein networkhttps://string-db.org/network/83332.Rv3469cRv3469c, (MTCY13E12.22c), len: 336 aa. Probable mhpE, 4-hydroxy-2-oxovalerate aldolase, similar to others (principally from Pseudomonas species) e.g. Q99PZ1|SCP1.301|SCP1.53c from Streptomyces co [...]
ilvB2 protein networkhttps://string-db.org/network/83332.Rv3470cPutative acetolactate synthase large subunit IlvB2; Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino a [...]
Rv3471c protein networkhttps://string-db.org/network/83332.Rv3471cConserved hypothetical protein; Rv3471c, (MTCY13E12.24c), len: 177 aa. Conserved hypothetical protein, similar to Q59013|MJ1618 hypothetical protein from Methanococcus jannaschii (125 aa), FASTA [...]
Rv3472 protein networkhttps://string-db.org/network/83332.Rv3472Conserved protein; Rv3472, (MTCY13E12.25), len: 168 aa. Conserved protein, showing some similarity to other proteins e.g. Q9ZAT9|DPSH daunorubicin biosynthesis enzyme from Streptomyces peucetius [...]
bpoA protein networkhttps://string-db.org/network/83332.Rv3473cRv3473c, (MTCY13E12.26c), len: 261 aa. Possible bpoA, peroxidase (non-haem peroxidase), similar to various enzymes or hypothetical unknown proteins e.g. O85849 hypothetical 26.2 KDA protein from [...]
Rv3474 protein networkhttps://string-db.org/network/83332.Rv3474Possible transposase for insertion element IS6110 (fragment); Rv3474, (MTCY13E12.27), len: 108 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transpos [...]
Rv3475 protein networkhttps://string-db.org/network/83332.Rv3475Possible transposase for insertion element IS6110 [second part]; Rv3475, (MTCY13E12.28), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 trans [...]
kgtP protein networkhttps://string-db.org/network/83332.Rv3476cRv3476c, (MTCY13E12.29c), len: 449 aa. Probable kgtP, dicarboxylate-transport integral membrane protein,possibly member of major facilitator superfamily (MFS),highly similar to others e.g. Q9HT43 [...]
PE31 protein networkhttps://string-db.org/network/83332.Rv3477Rv3477, (MTCY13E12.30), len: 98 aa. PE31, Member of the Mycobacterium tuberculosis PE family (see Brennan & Delogu 2002), similar to O53941|Rv1791|MTV049.13 (99 aa),FASTA scores: opt: 373, E(): 4 [...]
PPE60 protein networkhttps://string-db.org/network/83332.Rv3478Rv3478, (MTCY13E12.31), len: 393 aa. PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family, highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (3 [...]
Rv3479 protein networkhttps://string-db.org/network/83332.Rv3479Rv3479, (MTCY13E12.32), len: 1021 aa. Possible transmembrane protein, with hydrophobic stretches at C-terminus. Start changed since first submission (-54 aa). Alternative nucleotide at position 3 [...]
Rv3480c protein networkhttps://string-db.org/network/83332.Rv3480cPossible triacylglycerol synthase (diacylglycerol acyltransferase); Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain [...]
Rv3481c protein networkhttps://string-db.org/network/83332.Rv3481cRv3481c, (MTCY13E12.34c), len: 229 aa. Probable integral membrane protein. No real similarity with others.
Rv3482c protein networkhttps://string-db.org/network/83332.Rv3482cRv3482c, (MTCY13E12.35c), len: 260 aa. Probable conserved membrane protein. N-terminal region shares some similarity with N-terminus of O88067|SCI35.32c putative membrane protein from Streptomyce [...]
Rv3483c protein networkhttps://string-db.org/network/83332.Rv3483cPossible exported protein; Rv3483c, (MTCY13E12.36c), len: 220 aa. Possible exported protein, similar to Q9CC94|ML1099 putative lipoprotein from Mycobacterium leprae (202 aa), FASTA scores: opt: 2 [...]
cpsA protein networkhttps://string-db.org/network/83332.Rv3484Rv3484, (MTCY13E12.37), len: 512 aa. Possible cpsA,hypothetical protein, equivalent to Q50160|CPSA|ML2247 hypothetical protein CPSA from Mycobacterium leprae (516 aa), FASTA scores: opt: 2557, E( [...]
Rv3485c protein networkhttps://string-db.org/network/83332.Rv3485cRv3485c, (MTCY13E12.38c), len: 314 aa. Probable short-chain dehydrogenase/reductase, similar, but longer 41 aa, to P71824|Rv0769|MTCY369.14 putative short-chain type dehydrogenase/reductase CY369 [...]
Rv3486 protein networkhttps://string-db.org/network/83332.Rv3486Conserved protein; Rv3486, (MTCY13E12.39), len: 149 aa. Conserved protein, similar to Q9RC47|YFID|BH3304 hypothetical protein from Bacillus halodurans (129 aa), FASTA scores: opt: 186,E(): 2.1e-0 [...]
lipF protein networkhttps://string-db.org/network/83332.Rv3487cProbable esterase/lipase LipF; Hydrolyzes short-chain esters. Shows maximal activity with triacetin and p-nitrophenyl acetate.
Rv3488 protein networkhttps://string-db.org/network/83332.Rv3488Conserved hypothetical protein; May have transcription regulation and metal-detoxifying functions through which it may enhance intracellular survival of mycobacteria. Binds to its own promoter re [...]
Rv3489 protein networkhttps://string-db.org/network/83332.Rv3489Unknown protein; Rv3489, (MTCY13E12.42), len: 54 aa. Unknown protein. No similarity with other proteins.
otsA protein networkhttps://string-db.org/network/83332.Rv3490Trehalose-6-phosphate synthase; Involved in the production of glycogen and alpha-glucan via the TreS-Pep2 branch involved in the biosynthesis of maltose-1- phosphate (M1P), and probably in the os [...]
Rv3491 protein networkhttps://string-db.org/network/83332.Rv3491Unknown protein; Rv3491, (MTCY13E12.44), len: 192 aa. Unknown protein. No significant homology with other proteins.
Rv3492c protein networkhttps://string-db.org/network/83332.Rv3492cRv3492c, (MTCY13E12.45c), len: 160 aa. Conserved hypothetical Mce-associated protein, showing some similarity to hypothetical Mycobacterium tuberculosis proteins e.g. O53974|Rv1973|MTV051.11 (nea [...]
Rv3493c protein networkhttps://string-db.org/network/83332.Rv3493cRv3493c, (MTCY13E12.46c), len: 242 aa. Conserved hypothetical Mce-associated ala-, val-rich protein, showing weak similarity to O07422|Z97050|Rv0178|MTCI28.18 hypothetical 25.9 KDA protein (near [...]
mce4F protein networkhttps://string-db.org/network/83332.Rv3494cMce-family protein Mce4F; Rv3494c, (MTV023.01c), len: 564 aa. Mce4F; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), similar to Mycobacterium tuberculo [...]
lprN protein networkhttps://string-db.org/network/83332.Rv3495cPossible Mce-family lipoprotein LprN (Mce-family lipoprotein Mce4E); Stimulates the host (mouse) immune response; lipidated protein produced in E.coli stimulates T-cell proliferation in mice prev [...]
mce4D protein networkhttps://string-db.org/network/83332.Rv3496cMce-family protein Mce4D; Rv3496c, (MTV023.03c), len: 451 aa. Mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tu [...]
mce4C protein networkhttps://string-db.org/network/83332.Rv3497cMce-family protein Mce4C; Rv3497c, (MTV023.04c), len: 357 aa. Mce4C; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tu [...]
mce4B protein networkhttps://string-db.org/network/83332.Rv3498cMce-family protein Mce4B; Rv3498c, (MTV023.05c), len: 350 aa. Mce4B; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tu [...]
mce4A protein networkhttps://string-db.org/network/83332.Rv3499cMce-family protein Mce4A; Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tu [...]
yrbE4B protein networkhttps://string-db.org/network/83332.Rv3500cRv3500c, (MTV023.07c), len: 280 aa. YrbE4B,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis p [...]
yrbE4A protein networkhttps://string-db.org/network/83332.Rv3501cRv3501c, (MTV023.08c), len: 254 aa. YrbE4A,conserved integral membrane protein, part of mce4 operon and member of YrbE family (see citations below), highly similar to Mycobacterium tuberculosis p [...]
Rv3502c protein networkhttps://string-db.org/network/83332.Rv3502cProbable short-chain type dehydrogenase/reductase. Possible 17-beta-hydroxysteroid dehydrogenase; Rv3502c, (MTV023.09c), len: 317 aa (start uncertain). Probable short-chain dehydrogenase/reductas [...]
fdxD protein networkhttps://string-db.org/network/83332.Rv3503cRv3503c, (MTV023.10c), len: 63 aa. Probable fdxD,ferredoxin, equivalent to Q9R6Z5|B229_C3_226 hypothetical 9.3 KDA protein from Mycobacterium leprae (83 aa) FASTA scores: opt: 276, E(): 1.8e-13, [...]
fadE26 protein networkhttps://string-db.org/network/83332.Rv3504Probable acyl-CoA dehydrogenase FadE26; Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increa [...]
fadE27 protein networkhttps://string-db.org/network/83332.Rv3505Probable acyl-CoA dehydrogenase FadE27; Involved in the first cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by increa [...]
fadD17 protein networkhttps://string-db.org/network/83332.Rv3506Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase); Catalyzes the activation of long-chain fatty acids as acyl- coenzyme A (acyl-CoA), which are then transferred t [...]
PE_PGRS53 protein networkhttps://string-db.org/network/83332.Rv3507PE-PGRS family protein PE_PGRS53; Rv3507, (MTV023.14), len: 1381 aa. PE_PGRS53, Member of the Mycobacterium tuberculosis PE protein family, PGRS subfamily of gly-rich proteins (see citation below [...]
PE_PGRS54 protein networkhttps://string-db.org/network/83332.Rv3508PE-PGRS family protein PE_PGRS54; Rv3508, (MTV023.15), len: 1901 aa. PE_PGRS54, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan & Delogu 2002) [...]
ilvX protein networkhttps://string-db.org/network/83332.Rv3509cProbable acetohydroxyacid synthase IlvX (acetolactate synthase); Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the bra [...]
Rv3510c protein networkhttps://string-db.org/network/83332.Rv3510cConserved protein; Rv3510c, (MTV023.17), len: 278 aa. Conserved protein, similar to Q50662|Rv2303c|MTCY339.06 hypothetical 34.6 KDA protein from Mycobacterium tuberculosis (307 aa),FASTA scores: [...]
PE_PGRS55 protein networkhttps://string-db.org/network/83332.Rv3511PE-PGRS family protein PE_PGRS55; Rv3511, (MTV023.18), len: 714 aa. PE_PGRS55, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 200 [...]
PE_PGRS56 protein networkhttps://string-db.org/network/83332.Rv3512PE-PGRS family protein PE_PGRS56; Rv3512, (MTV023.19), len: 1079 aa. PE_PGRS56, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), simil [...]
fadD18 protein networkhttps://string-db.org/network/83332.Rv3513cProbable fatty-acid-CoA ligase FadD18 (Fatty-acid-CoA synthetase) (Fatty-acid-CoA synthase); Rv3513c, (MTV023.20c), len: 218 aa (Start uncertain). Probable fadD18, fatty-acid-CoA synthetase (C-te [...]
PE_PGRS57 protein networkhttps://string-db.org/network/83332.Rv3514PE-PGRS family protein PE_PGRS57; Rv3514, (MTV023.21), len: 1489 aa. PE_PGRS57, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), simil [...]
fadD19 protein networkhttps://string-db.org/network/83332.Rv3515cFatty-acid-CoA ligase FadD19 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Catalyzes the activation of long-chain fatty acids as acyl- coenzyme A (acyl-CoA), which are then transferred t [...]
echA19 protein networkhttps://string-db.org/network/83332.Rv3516Possible enoyl-CoA hydratase EchA19 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv3516, (MTV023.23), len: 263 aa. Possible echA19,enoyl-CoA hydratase, similar to other e.g. Q9ZH [...]
Rv3517 protein networkhttps://string-db.org/network/83332.Rv3517Rv3517, (MTV023.24), len: 279 aa. Hypothetical protein, similar to several hypothetical mycobacterial proteins e.g. P71763|Rv1482c|MTCY277.03c from Mycobacterium tuberculosis strain H37Rv (339 aa [...]
cyp142 protein networkhttps://string-db.org/network/83332.Rv3518cProbable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyze [...]
Rv3519 protein networkhttps://string-db.org/network/83332.Rv3519Unknown protein; Rv3519, (MTV023.26), len: 236 aa (start uncertain). Unknown protein. The C-terminal end is highly similar to N-terminal end of AAK47980|MT3620 hypothetical 7.8 KDA protein from M [...]
Rv3520c protein networkhttps://string-db.org/network/83332.Rv3520cRv3520c, (MTV023.27c), len: 347 aa. Possible coenzyme F420-dependent oxidoreductase, equivalent to Q9CCV8|ML0348 possible coenzyme F420-dependent oxidoreductase from Mycobacterium leprae (350 aa) [...]
Rv3521 protein networkhttps://string-db.org/network/83332.Rv3521Rv3521, (MTV023.28), len: 303 aa. Conserved hypothetical protein, similar to (although longer than) other conserved hypothetical proteins e.g. O29296|AF0966 from Archaeoglobus fulgidus (176 aa), [...]
ltp4 protein networkhttps://string-db.org/network/83332.Rv3522Rv3522, (MTV023.29), len: 354 aa. Possible ltp4,lipid carrier protein or keto acyl-CoA thiolase, similar to several e.g. O30103|AF0134 3-ketoacyl-CoA thiolase (ACAB-4) from Archaeoglobus fulgidus [...]
ltp3 protein networkhttps://string-db.org/network/83332.Rv3523Rv3523, (MTCY03C7.33c), len: 394 aa. Probable ltp3,lipid carrier protein or keto acyl-CoA thiolase, similar to several e.g. O30037|AF0202 3-ketoacyl-CoA thiolase (ACAB-6) from Archaeoglobus fulgi [...]
Rv3524 protein networkhttps://string-db.org/network/83332.Rv3524Rv3524, (MTCY03C7.32c), len: 343 aa. Probable conserved membrane protein, showing some similarity to C-terminal part of putative Mycobacterium tuberculosis proteins O05871|P95308|PKND_MYCTU|Rv093 [...]
Rv3525c protein networkhttps://string-db.org/network/83332.Rv3525cRv3525c, (MTCY3C7.31), len: 174 aa. Possible siderophore-binding protein, similar to ferripyochelin binding proteins (and related) e.g. Q9RSN5|DR2089 ferripyochelin-binding protein from Deinococc [...]
kshA protein networkhttps://string-db.org/network/83332.Rv3526Oxygenase component of 3-ketosteroid-9-alpha-hydroxylase KshA; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (AD [...]
Rv3527 protein networkhttps://string-db.org/network/83332.Rv3527Hypothetical protein; Rv3527, (MTCY03C7.29c), len: 149 aa. Hypothetical unknown protein.
Rv3528c protein networkhttps://string-db.org/network/83332.Rv3528cUnknown protein; Rv3528c, (MTCY03C7.28), len: 237 aa. Unknown protein. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Rv3529c protein networkhttps://string-db.org/network/83332.Rv3529cRv3529c, (MTCY03C7.27), len: 384 aa. Conserved hypothetical protein, showing some similarity to Q50695|YM67_MYCTU|Rv2267c|MT2329|MTCY339.43 hypothetical 46.1 KDA protein from Mycobacterium tuberc [...]
Rv3530c protein networkhttps://string-db.org/network/83332.Rv3530cRv3530c, (MTCY03C7.26), len: 260 aa. Possible oxidoreductase, similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 probable oxidoreductase from Rhizobium loti [...]
Rv3531c protein networkhttps://string-db.org/network/83332.Rv3531cHypothetical protein; Rv3531c, (MTCY03C7.25), len: 375 aa. Hypothetical unknown protein.
PPE62 protein networkhttps://string-db.org/network/83332.Rv3533cRv3533c, (MTCY03C7.23), len: 582 aa. PPE62, Member of the Mycobacterium tuberculosis PPE protein family,similar to many, e.g. O53309|Rv3159c|MTV014.03c (590 aa) FASTA scores: opt: 2289, E(): 2.3e [...]
hsaF protein networkhttps://string-db.org/network/83332.Rv3534cProbable 4-hydroxy-2-oxovalerate aldolase (HOA); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the d [...]
hsaG protein networkhttps://string-db.org/network/83332.Rv3535cProbable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the met [...]
hsaE protein networkhttps://string-db.org/network/83332.Rv3536cProbable hydratase; Rv3536c, (MTCY03C7.20), len: 261 aa. Probable hsaE,hydratase, 2-oxo-hepta-3-ene-1,7-dioate hydratase or 2-keto-4-pentenoate hydratase. Indeed, highly similar to many 2-oxo-hep [...]
kstD protein networkhttps://string-db.org/network/83332.Rv3537Probable dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 3-keto [...]
Rv3538 protein networkhttps://string-db.org/network/83332.Rv3538Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase; Rv3538, (MTCY03C7.18c), len: 286 aa. Probable double hotdog R-specific hydratase, substrate unknown, shows structural similarity to si [...]
PPE63 protein networkhttps://string-db.org/network/83332.Rv3539Rv3539, (MTCY03C7.17c), len: 479 aa. PPE63, Member of the Mycobacterium tuberculosis PPE protein family,similar to many e.g. O53949|Rv1800|MTV049.22 (655 aa),FASTA scores: opt: 914, E(): 7.3e-47, [...]
ltp2 protein networkhttps://string-db.org/network/83332.Rv3540cRv3540c, (MTCY03C7.16), len: 386 aa. Probable ltp2,lipid-transfer protein or keto acyl-CoA thiolase, similar to several e.g. Q9X4X2|DITF DITF protein (hypothetical protein, similar to non-specifi [...]
Rv3541c protein networkhttps://string-db.org/network/83332.Rv3541cConserved protein; Rv3541c, (MTCY03C7.15), len: 129 aa. Conserved protein, showing some similarity to Q9CBJ7|ML1909 hypothetical protein from Mycobacterium leprae (142 aa) FASTA scores: opt: 110, [...]
Rv3542c protein networkhttps://string-db.org/network/83332.Rv3542cRv3542c, (MTCY03C7.14), len: 311 aa. Hypothetical protein, showing some similarity to other e.g. Q58947|MJ1552 from Methanococcus jannaschii (141 aa) FASTA scores: opt: 177, E(): 0.00065, (46.65% [...]
fadE29 protein networkhttps://string-db.org/network/83332.Rv3543cProbable acyl-CoA dehydrogenase FadE29; Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. Contributes partly to the virulence by increasin [...]
fadE28 protein networkhttps://string-db.org/network/83332.Rv3544cProbable acyl-CoA dehydrogenase FadE28; Involved in the third cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. May play an important role for the initial macro [...]
cyp125 protein networkhttps://string-db.org/network/83332.Rv3545cProbable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequenti [...]
fadA5 protein networkhttps://string-db.org/network/83332.Rv3546Probable acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase); Involved in the beta-oxidation of the cholesterol side chain. It is important for utilization of cholesterol as a sole carb [...]
ddn protein networkhttps://string-db.org/network/83332.Rv3547Deazaflavin-dependent nitroreductase Ddn; Involved in a F420-dependent anti-oxidant mechanism that protects M.tuberculosis against oxidative stress and bactericidal agents. Catalyzes the F420H(2) [...]
Rv3548c protein networkhttps://string-db.org/network/83332.Rv3548cRv3548c, (MTCY03C7.08), len: 304 aa. Probable short-chain dehydrogenase/reductase, highly similar to various dehydrogenases/reductases (generally belonging to the SDR family) e.g. Q9I4V1|PA1023 f [...]
Rv3549c protein networkhttps://string-db.org/network/83332.Rv3549cRv3549c, (MTCY03C7.07), len: 259 aa. Probable short-chain dehydrogenase/reductase, similar to various dehydrogenases/reductases (generally belong to the SDR family) e.g. Q9UKU3 from Homo sapiens [...]
echA20 protein networkhttps://string-db.org/network/83332.Rv3550Probable enoyl-CoA hydratase EchA20 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv3550, (MTCY03C7.06c), len: 247 aa. Probable echA20, enoyl-CoA hydratase, similar to others e.g. [...]
Rv3551 protein networkhttps://string-db.org/network/83332.Rv3551Possible CoA-transferase (alpha subunit); Probable subunit of a CoA-transferase composed of Rv3551 and Rv3552.
Rv3552 protein networkhttps://string-db.org/network/83332.Rv3552Possible CoA-transferase (beta subunit); Probable subunit of a CoA-transferase composed of Rv3551 and Rv3552.
Rv3553 protein networkhttps://string-db.org/network/83332.Rv3553Rv3553, (MTCY03C7.02c), len: 355 aa. Possible oxidoreductase, highly similar (except in C-terminus) to Q9A327|CC3379 hypothetical protein from Caulobacter crescentus (321 aa), FASTA scores: opt: [...]
fdxB protein networkhttps://string-db.org/network/83332.Rv3554Possible electron transfer protein FdxB; Rv3554, (MTCY06G11.01, MTCY03C7.01c), len: 685 aa. Possible fdxB, two-domain protein, with ferredoxin reductase electron transfer component in C-terminal [...]
Rv3555c protein networkhttps://string-db.org/network/83332.Rv3555cConserved protein; Rv3555c, (MTCY06G11.02c), len: 289 aa. Conserved protein, highly similar to others from Mycobacterium tuberculosis e.g. O53562|AL022022|Rv3517|MTV023.24 (279 aa), FASTA scores: [...]
fadA6 protein networkhttps://string-db.org/network/83332.Rv3556cRv3556c, (MTCY06G11.03), len: 386 aa. Probable fadA6, acetyl-CoA acetyltransferase, similar to many e.g. Q9K409|2SCG61.06c from Streptomyces coelicolor (389 aa),FASTA scores: opt: 1091, E(): 2.9e [...]
kstR2 protein networkhttps://string-db.org/network/83332.Rv3557cTranscriptional regulatory protein (probably TetR-family); Controls the expression of a small regulon that may play a role in the utilization of cholesterol.
PPE64 protein networkhttps://string-db.org/network/83332.Rv3558Rv3558, (MTCY06G11.05), len: 552 aa. PPE64, Member of the Mycobacterium tuberculosis PPE family of glycine-rich proteins, similar to many e.g. P71868|Rv3533c|MTCY03C7.23 (582 aa), FASTA scores: o [...]
Rv3559c protein networkhttps://string-db.org/network/83332.Rv3559cProbable oxidoreductase; Rv3559c, (MTCY06G11.06c), len: 262 aa. Probable oxidoreductase, similar to various oxidoreductases e.g. Q9F5J1|SIM-NJ1|SIMD2 putative 3-keto-acyl-reductase (SDR family) f [...]
fadE30 protein networkhttps://string-db.org/network/83332.Rv3560cRv3560c, (MTCY06G11.07c), len: 385 aa. Probable fadE30, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V2|PA1022 from Pseudomonas aeruginosa (381 aa), FASTA scores: opt: 845, E(): 1.6e-47, (39. [...]
fadD3 protein networkhttps://string-db.org/network/83332.Rv3561Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase); Involved in the catabolism of the rings C and D of cholesterol. Catalyzes the ATP-dependent CoA thioest [...]
fadE31 protein networkhttps://string-db.org/network/83332.Rv3562Rv3562, (MTCY06G11.09), len: 377 aa. Probable fadE31, acyl-CoA dehydrogenase, similar to many e.g. Q9RJX2|SCF37.29c from Streptomyces coelicolor (393 aa),FASTA scores: opt: 657, E(): 1.7e-34, (36 [...]
fadE32 protein networkhttps://string-db.org/network/83332.Rv3563Rv3563, (MTCY06G11.10), len: 319 aa. Probable fadE32, acyl-CoA dehydrogenase, similar to many e.g. Q9I4V4|PA1020 from Pseudomonas aeruginosa (370 aa), FASTA scores: opt: 347, E(): 7.6e-14, (35.15 [...]
fadE33 protein networkhttps://string-db.org/network/83332.Rv3564Rv3564, (MTCY06G11.11), len: 318 aa. Probable fadE33, acyl-CoA dehydrogenase, similar to others e.g. Q9A5G8|CC2479 from Caulobacter crescentus (344 aa), FASTA scores: opt: 373, E(): 1.9e-15, (34. [...]
aspB protein networkhttps://string-db.org/network/83332.Rv3565Aminotransferase; Rv3565, (MTCY06G11.12), len: 388 aa. Possible aspB,aspartate aminotransferase, similar to many e.g. Q9A5J2|CC2455 aminotransferase class I from Caulobacter crescentus (381 aa), [...]
Rv3566A protein networkhttps://string-db.org/network/83332.Rv3566ARv3566A, len: 88 aa. Hypothetical unknown protein.
nat protein networkhttps://string-db.org/network/83332.Rv3566cArylamine N-acetyltransferase Nat (arylamine acetylase); Catalyzes the transfer of the acetyl group from acetyl coenzyme A to the free amino group of arylamines and hydrazines. Is able to utilize [...]
hsaB protein networkhttps://string-db.org/network/83332.Rv3567cFlavin-dependent monooxygenase, reductase subunit HsaB; Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit; Belo [...]
hsaC protein networkhttps://string-db.org/network/83332.Rv3568c3,4-DHSA dioxygenase; Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-di [...]
hsaD protein networkhttps://string-db.org/network/83332.Rv3569c4,9-DHSA hydrolase; Catalyzes the hydrolysis of a carbon-carbon bond in 4,5: 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate (4,9- DSHA) to yield 9,17-dioxo-1,2,3,4,10,19-hexanor [...]
hsaA protein networkhttps://string-db.org/network/83332.Rv3570cFlavin-dependent monooxygenase, oxygenase subunit HsaA; Catalyzes the o-hydroxylation of 3-hydroxy-9,10-secoandrosta- 1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy-9,10-secoandrosta- 1,3,5 [...]
kshB protein networkhttps://string-db.org/network/83332.Rv3571Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB; Involved in the degradation of cholesterol. Catalyzes the introduction of a 9a-hydroxyl moiety into 1,4-androstadiene-3,17-dione (AD [...]
Rv3572 protein networkhttps://string-db.org/network/83332.Rv3572Unknown protein; Rv3572, (MTCY06G11.19), len: 176 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al., 2008).
fadE34 protein networkhttps://string-db.org/network/83332.Rv3573cProbable acyl-CoA dehydrogenase FadE34; Involved in the second cycle of side chain dehydrogenation in the beta-oxidation of cholesterol catabolism. It contributes partly to the virulence by incre [...]
kstR protein networkhttps://string-db.org/network/83332.Rv3574Transcriptional regulatory protein KstR (probably TetR-family); Controls the expression of genes used for utilizing diverse lipids as energy sources.
Rv3575c protein networkhttps://string-db.org/network/83332.Rv3575cTranscriptional regulatory protein (probably LacI-family); Rv3575c, (MTCY06G11.22c), len: 359 aa. Probable transcriptional regulator belonging to lacI family, similar to others e.g. BAB53947|MLL8 [...]
lppH protein networkhttps://string-db.org/network/83332.Rv3576Rv3576, (MTCY06G11.23), len: 237 aa. Possible lppH,conserved lipoprotein, similar in part with proteins from Mycobacterium tuberculosis; C-terminus of Q11053|PKNH_MYCTU|PKNH|Rv1266c|MT1304|MTCY50 [...]
Rv3577 protein networkhttps://string-db.org/network/83332.Rv3577Conserved hypothetical protein; Rv3577, (MTCY06G11.24), len: 288 aa (other start sites possible upstream; equivalent to AAK48041 from Mycobacterium tuberculosis strain CDC1551 (379 aa) but shorte [...]
arsB2 protein networkhttps://string-db.org/network/83332.Rv3578Rv3578, (MTCY06G11.25), len: 413 aa. Possible arsB2,arsenical pump integral membrane protein, similar to many e.g. Q9I1J6|ARSB|PA2278 from Pseudomonas aeruginosa (427 aa), FASTA scores: opt: 375, [...]
Rv3579c protein networkhttps://string-db.org/network/83332.Rv3579cRv3579c, (MTCY06G11.26c), len: 322 aa. Possible tRNA/rRNA methyltransferase, equivalent, but longer 31 aa,to Q9CCW4|ML0324 putative methyltransferase from Mycobacterium leprae (278 aa), FASTA sco [...]
cysS1 protein networkhttps://string-db.org/network/83332.Rv3580cCysteinyl-tRNA synthetase 1 CysS1 (cysteine--tRNA ligase 1) (CYSRS 1) (cysteine translase); Rv3580c, (MTCY06G11.27c), len: 469 aa. Probable cysS1, cysteinyl-tRNA synthetase, equivalent to P57990| [...]
ispF protein networkhttps://string-db.org/network/83332.Rv3581cProbable 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF (MECPS); Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building [...]
ispD protein networkhttps://string-db.org/network/83332.Rv3582c4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (MEP cytidylyltransferase) (MCT); Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythrit [...]
carD protein networkhttps://string-db.org/network/83332.Rv3583cPossible transcription factor; Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice; Belongs to the CarD family.
lpqE protein networkhttps://string-db.org/network/83332.Rv3584Rv3584, (MTV024.02), len: 182 aa. Possible lpqE,conserved lipoprotein, equivalent to Q9ZBM7|MLCB1450.02|LPQE|ML0319 putative lipoprotein from Mycobacterium leprae (183 aa), FASTA scores: opt: 722 [...]
radA protein networkhttps://string-db.org/network/83332.Rv3585DNA repair protein RadA (DNA repair protein SMS); DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration [...]
disA protein networkhttps://string-db.org/network/83332.Rv3586Conserved hypothetical protein; Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions. Belongs to the DisA family.
Rv3587c protein networkhttps://string-db.org/network/83332.Rv3587cRv3587c, (MTV024.05c), len: 264 aa. Probable conserved membrane protein, equivalent to Q9CBJ2|ML1918 hypothetical membrane protein from Mycobacterium leprae (263 aa), FASTA scores: opt: 1438, E() [...]
canB protein networkhttps://string-db.org/network/83332.Rv3588cBeta-carbonic anhydrase CanB; Catalyzes the reversible hydration of carbon dioxide to form bicarbonate; Belongs to the beta-class carbonic anhydrase family.
mutY protein networkhttps://string-db.org/network/83332.Rv3589Probable adenine glycosylase MutY; Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Minor activity against 8-oxoG:G and 8- [...]
PE_PGRS58 protein networkhttps://string-db.org/network/83332.Rv3590cPE-PGRS family protein PE_PGRS58; Rv3590c, (MTV024.08c, MTCY6F7.04), len: 584 aa. PE_PGRS58, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation [...]
Rv3591c protein networkhttps://string-db.org/network/83332.Rv3591cPossible hydrolase; Rv3591c, (MTCY6F7.03), len: 257 aa. Possible hydrolase, equivalent to Q9CBI9|ML1921 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1421,E(): 5.6e-8 [...]
mhuD protein networkhttps://string-db.org/network/83332.Rv3592Possible heme degrading protein MhuD; Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrom [...]
lpqF protein networkhttps://string-db.org/network/83332.Rv3593Rv3593, (MTCY6F7.01c), len: 452 aa. Probable lpqF,conserved lipoprotein, equivalent to Q9CBI7|MPQF|ML1923 probale secreted protein from Mycobacterium leprae (454 aa), FASTA scores: opt: 2465, E() [...]
Rv3594 protein networkhttps://string-db.org/network/83332.Rv3594Rv3594, (MTCY07H7B.28c), len: 275 aa. Hypothetical protein, highly similar in part with Q9ZX49|GP29 from Mycobacteriophage TM4 (547 aa), FASTA scores: opt: 526,E(): 1.3e-25, (46.25% identity in 1 [...]
PE_PGRS59 protein networkhttps://string-db.org/network/83332.Rv3595cPE-PGRS family protein PE_PGRS59; Rv3595c, (MTCY07H7B.27), len: 439 aa. PE_PGRS59,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below),simi [...]
clpC1 protein networkhttps://string-db.org/network/83332.Rv3596cProbable ATP-dependent protease ATP-binding subunit ClpC1; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions [...]
lsr2 protein networkhttps://string-db.org/network/83332.Rv3597cIron-regulated H-NS-like protein Lsr2; DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifica [...]
lysS protein networkhttps://string-db.org/network/83332.Rv3598cLysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase); Rv3598c, (MTCY07H7B.24), len: 505 aa. Probable lysS,lysyl-tRNA synthetase 1, equivalent to P46861|SYK_MYCLE|LYSS [...]
coaX protein networkhttps://string-db.org/network/83332.Rv3600cConserved protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
panD protein networkhttps://string-db.org/network/83332.Rv3601cProbable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD famil [...]
panC protein networkhttps://string-db.org/network/83332.Rv3602cPantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-aden [...]
Rv3603c protein networkhttps://string-db.org/network/83332.Rv3603cRv3603c, (MTCY07H7B.19), len: 303 aa. Conserved hypothetical ala-, leu-rich protein, identical except at N-terminus (really different) to AAK48066|MT3708 chalcone/stilbene synthase family protein [...]
Rv3604c protein networkhttps://string-db.org/network/83332.Rv3604cRv3604c, (MTCY07H7B.18), len: 397 aa. Probable conserved ala-, arg-, pro-rich transmembrane protein,equivalent to O69526|MLCB2548.03c|ML0228 putative membrane protein from Mycobacterium leprae (4 [...]
Rv3605c protein networkhttps://string-db.org/network/83332.Rv3605cRv3605c, (MTCY07H7B.17), len: 158 aa. Probable conserved secreted or membrane protein, identical to O69527|MLCB2548.04c|ML0227 putative membrane protein from Mycobacterium leprae (158 aa), FASTA [...]
folK protein networkhttps://string-db.org/network/83332.Rv3606cRv3606c, (MTCY07H7B.16), len: 188 aa. Probable folK,2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, equivalent to O69528|HPPK_MYCLE|folk|ML0226MLCB2548.05c 2-amino-4-hydroxy-6- [...]
folB protein networkhttps://string-db.org/network/83332.Rv3607cProbable dihydroneopterin aldolase FolB (DHNA); Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respect [...]
folP1 protein networkhttps://string-db.org/network/83332.Rv3608cDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate [...]
folE protein networkhttps://string-db.org/network/83332.Rv3609cGTP cyclohydrolase I FolE (GTP-ch-I); Rv3609c, (MTCY07H7B.13), len: 202 aa. Probable folE (alternate gene name: gchA), GTP cyclohydrolase I,equivalent to O69531|GCH1_MYCLE|FOLE|ML0223|MLCB2548.08 [...]
ftsH protein networkhttps://string-db.org/network/83332.Rv3610cMembrane-bound protease FtsH (cell division protein); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of [...]
Rv3611 protein networkhttps://string-db.org/network/83332.Rv3611Rv3611, (MTCY07H7B.11c), len: 217 aa. Hypothetical unknown arg-, pro-rich protein. Possible ORF containing several direct repeats.
Rv3612c protein networkhttps://string-db.org/network/83332.Rv3612cRv3612c, (MTCY07H7B.10), len: 109 aa. Conserved hypothetical protein. Residues 58 to 81 highly similar to N-terminal part of AAK46718|MT2424 hypothetical 3.9 KDA protein from Mycobacterium tuberc [...]
Rv3613c protein networkhttps://string-db.org/network/83332.Rv3613cHypothetical protein; Rv3613c, (MTCY07H7B.09), len: 53 aa. Hypothetical unknown protein.
espD protein networkhttps://string-db.org/network/83332.Rv3614cESX-1 secretion-associated protein EspD; Required for ESX-1 function. Required for the maintenance of adequate cellular levels of both EspA and EspC. Facilitates EsxA secretion.
espC protein networkhttps://string-db.org/network/83332.Rv3615cESX-1 secretion-associated protein EspC; Required for ESX-1 function. Required for either stability or expression of EspA.
espA protein networkhttps://string-db.org/network/83332.Rv3616cESX-1 secretion-associated protein A, EspA; Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) and for virulence. Involved in translocation of bacteria from the host (human) phagolysosome [...]
ephA protein networkhttps://string-db.org/network/83332.Rv3617Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase); Could be involved in detoxification of extraneous host-cell epoxides. Catalyzes the hydrolysis of epoxide-containing s [...]
Rv3618 protein networkhttps://string-db.org/network/83332.Rv3618Possible monooxygenase; Rv3618, (MTCY15C10.34c, MTCY07H7B.04c), len: 395 aa. Possible monooxygenase, similar to others (principally bacterial luciferases alpha chain) e.g. Q9JN87|MMYO putative al [...]
esxV protein networkhttps://string-db.org/network/83332.Rv3619cRv3619c, (MTCY15C10.33, MTCY07H7B.03, MT3721), len: 94 aa. EsxV, ESAT-6 like protein (see citations below),highly similar to many Mycobacterial ESAT-6 like proteins e.g. O53942|ES65_MYCTU putativ [...]
esxW protein networkhttps://string-db.org/network/83332.Rv3620cRv3620c, (MTCY15C10.32, MTCY07H7B.02, MT3722), len: 98 aa. EsxW, ESAT-6 like protein (see citation below). Member of the M. tuberculosis hypothetical QILSS protein family with Rv1038c, Rv1792, Rv [...]
PPE65 protein networkhttps://string-db.org/network/83332.Rv3621cPPE family protein PPE65; Rv3621c, (MTCY15C10.31, MTCY07H7B.01), len: 413 aa. PPE65, Member of the Mycobacterium tuberculosis PPE family,ala-, gly-rich proteins, similar to many e.g. Q10813|YS92_ [...]
PE32 protein networkhttps://string-db.org/network/83332.Rv3622cRv3622c, (MTCY15C10.30), len: 99 aa. PE32, Member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002), but no glycine rich C-terminus present. Similar to others e.g. O53938 [...]
lpqG protein networkhttps://string-db.org/network/83332.Rv3623Rv3623, (MTCY15C10.29c), len: 240 aa. Probable lpqG,conserved lipoprotein, showing some similarity with hypothetical proteins e.g. Q57432 from Methanosarcina barkeri (251 aa), FASTA scores: opt: [...]
hpt protein networkhttps://string-db.org/network/83332.Rv3624cRv3624c, (MTCY15C10.28), len: 216 aa. Hpt (alternate gene name: hprT), hypoxanthine-guanine phosphoribosyltransferase (but seems to have a 35 aa extension at N-terminus), equivalent to other myco [...]
mesJ protein networkhttps://string-db.org/network/83332.Rv3625cPossible cell cycle protein MesJ; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine [...]
Rv3626c protein networkhttps://string-db.org/network/83332.Rv3626cRv3626c, (MTCY15C10.26), len: 350 aa. Conserved hypothetical protein, similar to Q9X8I7|SCE9.14c hypothetical protein from Streptomyces coelicolor (375 aa) FASTA scores: opt: 720, E(): 2.2e-38, ( [...]
Rv3627c protein networkhttps://string-db.org/network/83332.Rv3627cConserved protein; Carboxypeptidase that cleaves terminal D-alanine from peptidoglycan in the mycobacterial cell wall. May cleave L-Lys-D-Ala and/or D-Ala-D-Ala peptide bonds. Exerts important ef [...]
ppa protein networkhttps://string-db.org/network/83332.Rv3628Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Rv3629c protein networkhttps://string-db.org/network/83332.Rv3629cRv3629c, (MTCY15C10.23), len: 365 aa. Probable conserved integral membrane protein, equivalent to O69543|MLCB2548.26|ML0205 putative membrane protein from Mycobacterium leprae (356 aa), FASTA sco [...]
Rv3630 protein networkhttps://string-db.org/network/83332.Rv3630Rv3630, (MTCY15C10.22c), len: 431 aa. Probable conserved integral membrane, highly similar to P71789|YF10_MYCTU|Rv1510|MTCY277.32 hypothetical 44.3 KDA protein from Mycobacterium tuberculosis (43 [...]
Rv3631 protein networkhttps://string-db.org/network/83332.Rv3631Rv3631, (MTCY15C10.21c), len: 241 aa. Possible transferase, more specifically a glycosyltransferase, equivalent to O69542|MLCB2548.24c|ML0207 putative transferase (putative glycosyltransferase) f [...]
Rv3632 protein networkhttps://string-db.org/network/83332.Rv3632Rv3632, (MTCY15C10.20c), len: 114 aa. Possible conserved membrane protein, equivalent to O69541|MLCB2548.23c|ML0208 hypothetical 12.9 KDA protein (putative membrane protein) from Mycobacterium le [...]
Rv3633 protein networkhttps://string-db.org/network/83332.Rv3633Conserved protein; Rv3633, (MTCY15C10.19c), len: 291 aa. Conserved protein, similar to Q9X5S6|MMCH from Streptomyces lavendulae (254 aa), FASTA scores: opt: 368, E(): 3.2e-16,(35.05% identity in [...]
galE1 protein networkhttps://string-db.org/network/83332.Rv3634cUDP-glucose 4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reductio [...]
Rv3635 protein networkhttps://string-db.org/network/83332.Rv3635Rv3635, (MTCY15C10.17c), len: 591 aa (start unclear). Probable conserved transmembrane protein,equivalent, but longer 25 aa, to O69545|ML0203|MLCB2548.28 putative membrane protein from Mycobacter [...]
Rv3636 protein networkhttps://string-db.org/network/83332.Rv3636Possible transposase; Rv3636, (MTCY15C10.16c), len: 115 aa. Possible transposase, weakly similar to others e.g. O69924|SC3C8.12 putative transposase from Streptomyces coelicolor (487 aa) FASTA sc [...]
Rv3637 protein networkhttps://string-db.org/network/83332.Rv3637Possible transposase; Rv3637, (MTCY15C10.15c), len: 166 aa. Possible transposase. C-terminal end highly similar to Q9RLQ9|ISTA putative transposase a (fragment) from Mycobacterium bovis (102 aa), [...]
Rv3638 protein networkhttps://string-db.org/network/83332.Rv3638Possible transposase; Rv3638, (MTCY15C10.14c), len: 248 aa. Possible transposase, highly similar to Q9RLQ8|ISTB ISTB protein from Mycobacterium bovis (266 aa), FASTA scores: opt: 784,E(): 4e-46, [...]
Rv3639c protein networkhttps://string-db.org/network/83332.Rv3639cRv3639c, (MTCY15C10.13), len: 188 aa. Hypothetical protein, with C-terminus highly similar to N-terminus of P95044|Rv0698|MTCY210.15 hypothetical 22.3 KDA protein from Mycobacterium tuberculosis [...]
Rv3640c protein networkhttps://string-db.org/network/83332.Rv3640cProbable transposase; Required for the transposition of the insertion element.
fic protein networkhttps://string-db.org/network/83332.Rv3641cRv3641c, (MTCY15C10.11), len: 211 aa. Possible fic,cell filamentation protein, similar to others e.g. Q9PCU8|XF1657 cell filamentation protein from Xylella fastidiosa (203 aa), FASTA scores: opt: [...]
Rv3642c protein networkhttps://string-db.org/network/83332.Rv3642cHypothetical protein; Rv3642c, (MTCY15C10.10), len: 64 aa. Hypothetical unknown protein.
Rv3644c protein networkhttps://string-db.org/network/83332.Rv3644cPossible DNA polymerase; Rv3644c, (MTCY15C10.08), len: 401 aa. Possible DNA polymerase, equivalent to O69546|MLCB2548.29c|ML0202 hypothetical 42.7 KDA protein from Mycobacterium leprae (405 aa), [...]
Rv3645 protein networkhttps://string-db.org/network/83332.Rv3645Rv3645, (MTCY15C10.07c), len: 549 aa. Probable conserved transmembrane protein, equivalent, but longer 20 aa, to O69547|ML0201|MLCB2548.30 putative membrane protein from Mycobacterium leprae (530 [...]
topA protein networkhttps://string-db.org/network/83332.Rv3646cDNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of [...]
Rv3647c protein networkhttps://string-db.org/network/83332.Rv3647cConserved hypothetical protein; Rv3647c, (MTCY15C10.05), len: 192 aa. Conserved hpothetical protein, equivalent to O69549|MLCB2548.32c|ML0199 conserved hypothetical protein from Mycobacterium lep [...]
cspA protein networkhttps://string-db.org/network/83332.Rv3648cRv3648c, (MTCY15C10.04), len: 67 aa. Probable cspA,cold shock protein A, identical to O69550|CSPB|CSPA|ML0198 small cold-shock protein from Mycobacterium leprae (67 aa) FASTA scores: opt: 451, E( [...]
Rv3649 protein networkhttps://string-db.org/network/83332.Rv3649Probable helicase; Rv3649, (MTCY15C10.03c), len: 771 aa. Probable helicase, similar to many (known or hypothetical) ATP-dependent helicases e.g. Q9X915|SCH5.13 putative helicase from Streptomyces [...]
PE33 protein networkhttps://string-db.org/network/83332.Rv3650Rv3650, (MTCY15C10.02c), len: 94 aa. PE33, Short protein, member of the Mycobacterium tuberculosis PE family (see Brennan and Delogu, 2002), but without the repetitive gly-rich region, similar to [...]
Rv3651 protein networkhttps://string-db.org/network/83332.Rv3651Rv3651, (MTCY15C10.01c), len: 345 aa. Hypothetical protein, with some similarity to Q9ZHK1 hypothetical 36.5 KDA protein from Rhodococcus sp. X309 (329 aa) FASTA scores: opt: 332, E(): 3.4e-13, ( [...]
PE_PGRS60 protein networkhttps://string-db.org/network/83332.Rv3652PE-PGRS family-related protein PE_PGRS60; Binds fibronectin. May contribute to pathogenicity.
PE_PGRS61 protein networkhttps://string-db.org/network/83332.Rv3653PE-PGRS family-related protein PE_PGRS61; Mediates Ca(2+)-dependent up-regulation of the anti- inflammatory cytokine IL-10; Belongs to the mycobacterial PE family. PGRS subfamily.
Rv3654c protein networkhttps://string-db.org/network/83332.Rv3654cConserved hypothetical protein; Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Recognizes the host polypyrimidine tract binding p [...]
Rv3655c protein networkhttps://string-db.org/network/83332.Rv3655cConserved hypothetical protein; Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Interferes with caspase-8 activation and binds to [...]
Rv3656c protein networkhttps://string-db.org/network/83332.Rv3656cRv3656c, (MTV025.004c), len: 68 aa. Conserved hypothetical protein, similar to Q9X918|SCH5.16c small hypothetical protein from Streptomyces coelicolor (75 aa),FASTA scores: opt: 129, E(): 0.0039, [...]
Rv3657c protein networkhttps://string-db.org/network/83332.Rv3657cRv3657c, (MTV025.005c), len: 191 aa. Possible conserved membrane protein, rich in ala residues, similar to Q9X919|SCH5.17c putative integral membrane protein from Streptomyces coelicolor (267 aa) [...]
Rv3658c protein networkhttps://string-db.org/network/83332.Rv3658cRv3658c, (MTV025.006c), len: 266 aa. Probable conserved transmembrane protein, similar to Q9X920|SCH5.18c putative integral membrane protein from Streptomyces coelicolor (321 aa), FASTA scores: o [...]
Rv3659c protein networkhttps://string-db.org/network/83332.Rv3659cRv3659c, (MTV025.007c), len: 352 aa. Conserved hypothetical protein, highly similar, but always shorter (various lengths) at N-terminus, to Q9X921|SCH5.19c putative secretory protein from Strepto [...]
Rv3660c protein networkhttps://string-db.org/network/83332.Rv3660cConserved hypothetical protein; May play a role in septum formation.
Rv3661 protein networkhttps://string-db.org/network/83332.Rv3661Rv3661, (MTV025.009), len: 287 aa. Conserved hypothetical protein, highly similar to O33611|IMD_STRCN from Streptomyces cyaneus (Streptomyces curacoi) protein involved in inhibition of morphologi [...]
Rv3662c protein networkhttps://string-db.org/network/83332.Rv3662cRv3662c, (MTV025.010c), len: 256 aa. Conserved hypothetical protein, equivalent to Q9CB99|ML2289 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255, E(): 3.3e-69, (78 [...]
dppD protein networkhttps://string-db.org/network/83332.Rv3663cRv3663c, (MTV025.011c), len: 548 aa. Probable dppD,dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 probabl [...]
dppC protein networkhttps://string-db.org/network/83332.Rv3664cRv3664c, (MTV025.012c), len: 266 aa. Probable dppC,dipeptide-transport integral membrane protein ABC-transporter (see Braibant et al., 2000), similar to many peptide permeases e.g. Q9F351|SC9E12. [...]
dppB protein networkhttps://string-db.org/network/83332.Rv3665cRv3665c, (MTV025.013c), len: 308 aa. Probable dppB,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F352|SC9E12.03 puta [...]
dppA protein networkhttps://string-db.org/network/83332.Rv3666cRv3666c, (MTV025.014c), len: 541 aa. Probable dppA,dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F3 [...]
acs protein networkhttps://string-db.org/network/83332.Rv3667Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step [...]
Rv3668c protein networkhttps://string-db.org/network/83332.Rv3668cPossible protease; Rv3668c, (MTV025.016c), len: 232 aa. Possible protease (and more specifically a putative alkaline serine protease, equivalent to Q9CB98|ML2295 hypothetical protein from Mycobac [...]
Rv3669 protein networkhttps://string-db.org/network/83332.Rv3669Rv3669, (MTV025.017), len: 172 aa. Probable conserved transmembrane protein, equivalent to Q9CB97|ML2296 putative membrane protein from Mycobacterium leprae (181 aa), FASTA scores: opt: 863, E(): [...]
ephE protein networkhttps://string-db.org/network/83332.Rv3670Rv3670, (MTV025.018), len: 327 aa. Possible ephE,epoxide hydrolase (see citation below), equivalent to Q9CB96|ML2297 putative hydrolase from Mycobacterium leprae (324 aa), FASTA scores: opt: 1799 [...]
Rv3671c protein networkhttps://string-db.org/network/83332.Rv3671cMembrane-associated serine protease; Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tube [...]
Rv3672c protein networkhttps://string-db.org/network/83332.Rv3672cRv3672c, (MTV025.020c), len: 273 aa. Conserved hypothetical protein, equivalent to Q9CB94|ML2299 hypothetical protein from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358, E(): 5.2e-75, (76 [...]
Rv3673c protein networkhttps://string-db.org/network/83332.Rv3673cRv3673c, (MTV025.021c), len: 227 aa. Possible membrane protein, thioredoxin-like protein (thiol-disulfide interchange protein), equivalent to Q9CB93|ML2300 putative membrane protein from Mycobact [...]
nth protein networkhttps://string-db.org/network/83332.Rv3674cEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- [...]
Rv3675 protein networkhttps://string-db.org/network/83332.Rv3675Possible membrane protein; Rv3675, (MTV025.023), len: 125 aa. Possible membrane protein, with some similarity to Q9YCZ2|APE1120 hypothetical 11.7 KDA protein from Aeropyrum pernix (103 aa), FASTA [...]
crp protein networkhttps://string-db.org/network/83332.Rv3676Transcriptional regulatory protein Crp (Crp/Fnr-family); Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate trans [...]
Rv3677c protein networkhttps://string-db.org/network/83332.Rv3677cPossible hydrolase; Rv3677c, (MTV025.025c), len: 264 aa. Possible hydrolase, equivalent to Q9CB90|ML2303 putative hydrolase from Mycobacterium leprae (262 aa) FASTA scores: opt: 1400,E(): 8.5e-81 [...]
Rv3678A protein networkhttps://string-db.org/network/83332.Rv3678ARv3678A, len: 53 aa. Conserved hypothetical protein,similar to SCH17.10|AL079353_10 conserved hypothetical protein from Streptomyces coelicolor (53 aa), FASTA scores: opt: 259, E(): 1.5e-13, (78. [...]
Rv3678c protein networkhttps://string-db.org/network/83332.Rv3678cConserved protein; Rv3678c, (MTV025.026c), len: 151 aa. Conserved protein, equivalent, but shorter 23 aa, to Q9CB89|ML2304 hypothetical protein from Mycobacterium leprae (174 aa),FASTA scores: op [...]
Rv3679 protein networkhttps://string-db.org/network/83332.Rv3679Rv3679, (MTV025.027), len: 340 aa. Probable anion transporting ATPase, equivalent to Q9CB88|ML2305 probable anion transporter protein from Mycobacterium leprae (341 aa), FASTA scores: opt: 1810, [...]
Rv3680 protein networkhttps://string-db.org/network/83332.Rv3680Rv3680, (MTV025.028), len: 386 aa. Probable anion transporting ATPase, equivalent to Q9CB87|ML2306 probable anion transporter protein from Mycobacterium leprae (381 aa), FASTA scores: opt: 2131, [...]
whiB4 protein networkhttps://string-db.org/network/83332.Rv3681cProbable transcriptional regulatory protein WhiB-like WhiB4; Redox-responsive transcriptional regulator that regulates a set of genes involved in protection against environmental stresses encount [...]
ponA2 protein networkhttps://string-db.org/network/83332.Rv3682PASTA domain-containing protein; Rv3682, (MTV025.030), len: 810 aa. Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase and transpep [...]
Rv3683 protein networkhttps://string-db.org/network/83332.Rv3683Conserved protein; Rv3683, (MTV025.031), len: 319 aa. Conserved protein, equivalent to Q9CB84|ML2309 hypothetical protein from Mycobacterium leprae (330 aa) FASTA scores: opt: 1791,E(): 9e-107, ( [...]
Rv3684 protein networkhttps://string-db.org/network/83332.Rv3684Probable lyase; Rv3684, (MTV025.032), len: 346 aa. Probable lyase, and more specifically a cysteine synthase, highly similar to many lyases e.g. Q9K3N2|SCG20A.08c putative lyase from Streptomyces [...]
cyp137 protein networkhttps://string-db.org/network/83332.Rv3685cRv3685c, (MTV025.033c), len: 476 aa. Probable cyp137, cytochrome P-450, similar to many e.g. Q9VXY0|C4S3_DROME|CYP4S3|CG9081 from Drosophila melanogaster (Fruit fly) (495 aa), FASTA scores: opt: [...]
Rv3686c protein networkhttps://string-db.org/network/83332.Rv3686cRv3686c, (MTV025.034c), len: 110 aa. Hypothetical protein, similar to P96893|Rv3288c|MTCY71.28c hypothetical 15.2 KDA protein from Mycobacterium tuberculosis (and Mycobacterium bovis) (137 aa) FA [...]
rsfB protein networkhttps://string-db.org/network/83332.Rv3687cAnti-anti-sigma factor RsfB (anti-sigma factor antagonist) (regulator of sigma F B); Positive regulator of sigma-F (SigF) activity. Binds to anti- sigma-F factor RsbW (UsfX) preventing its bindin [...]
Rv3688c protein networkhttps://string-db.org/network/83332.Rv3688cConserved protein; Rv3688c, (MTV025.036c), len: 154 aa. Conserved protein, similar to other bacterial hypothetical proteins e.g. Q9X934|SCH66.02c from Streptomyces coelicolor (154 aa), FASTA scor [...]
Rv3689 protein networkhttps://string-db.org/network/83332.Rv3689Rv3689, (MTV025.037), len: 451 aa. Probable conserved transmembrane protein, with Proline rich N-terminus, similar to Q9KYW6|SCE33.17 putative integral membrane protein from Streptomyces coelicol [...]
Rv3690 protein networkhttps://string-db.org/network/83332.Rv3690Rv3690, (MTV025.038), len: 217 aa. Probable conserved membrane protein, similar to Q9KYW5|SCE33.18 putative integral membrane protein from Streptomyces coelicolor (231 aa), FASTA scores: opt: 419 [...]
Rv3691 protein networkhttps://string-db.org/network/83332.Rv3691Conserved protein; Rv3691, (MTV025.039), len: 333 aa. Conserved protein, similar to Q9KYW4|SCE33.19 putative secreted protein from Streptomyces coelicolor (387 aa) FASTA scores: opt: 481, E(): 6e [...]
moxR2 protein networkhttps://string-db.org/network/83332.Rv3692Rv3692, (MTV025.040), len: 358 aa. Probable moxR2,methanol dehydrogenase regulatory protein, highly similar (generally longer at N-terminus) to Q9KYW3|SCE33.20 putative regulatory protein from St [...]
Rv3693 protein networkhttps://string-db.org/network/83332.Rv3693Possible conserved membrane protein; Rv3693, (MTV025.041), len: 440 aa (alternative start at 41910). Possible conserved membrane protein, similar to Q9KYW2|SCE33.21 putative lipoprotein from Stre [...]
Rv3694c protein networkhttps://string-db.org/network/83332.Rv3694cRv3694c, (MTV025.042c), len: 330 aa. Possible conserved transmembrane protein, highly similar to Q9KZM4|SCE34.01c putative integral membrane protein from Streptomyces coelicolor (335 aa), FASTA s [...]
Rv3695 protein networkhttps://string-db.org/network/83332.Rv3695Rv3695, (MTV025.043), len: 310 aa. Possible conserved membrane protein, equivalent, but longer 88 aa,to Q9CB83|ML2312 possible membrane protein from Mycobacterium leprae (196 aa), FASTA scores: o [...]
glpK protein networkhttps://string-db.org/network/83332.Rv3696cProbable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol t [...]
vapB48 protein networkhttps://string-db.org/network/83332.Rv3697APossible antitoxin VapB48; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC48.
vapC48 protein networkhttps://string-db.org/network/83332.Rv3697cPossible toxin VapC48. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB48.; Belongs to the PINc/VapC protein family.
Rv3698 protein networkhttps://string-db.org/network/83332.Rv3698Conserved protein; Rv3698, (MTV025.046), len: 509 aa. Conserved protein, highly similar to Q9AK89|SC10A9.15c conserved hypothetical protein from Streptomyces coelicolor (505 aa),FASTA scores: opt [...]
Rv3699 protein networkhttps://string-db.org/network/83332.Rv3699Conserved protein; Rv3699, (MTV025.047), len: 233 aa. Conserved protein, showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from [...]
egtE protein networkhttps://string-db.org/network/83332.Rv3700cConserved hypothetical protein; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine. Ergothioneine is an antioxidant that protects mycobacteria from oxidative stress. [...]
egtD protein networkhttps://string-db.org/network/83332.Rv3701cConserved hypothetical protein; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belon [...]
egtC protein networkhttps://string-db.org/network/83332.Rv3702cConserved hypothetical protein; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the bi [...]
egtB protein networkhttps://string-db.org/network/83332.Rv3703cConserved hypothetical protein; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in [...]
gshA protein networkhttps://string-db.org/network/83332.Rv3704cGlutamate--cysteine ligase EgtA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothio [...]
Rv3705A protein networkhttps://string-db.org/network/83332.Rv3705ARv3705A, len: 129 aa. Conserved hypothetical protein, similar to downstream ORF O69674|Rv3706c|MTV025.054c conserved hypothetical proline rich protein from Mycobacterium tuberculosis (106 aa),FAS [...]
Rv3705c protein networkhttps://string-db.org/network/83332.Rv3705cConserved protein; Rv3705c, (MTV025.053c), len: 214 aa. Conserved protein, equivalent to Q9CB80|ML2320 hypothetical protein from Mycobacterium leprae (215 aa) FASTA scores: opt: 1145,E(): 5.9e-68 [...]
Rv3706c protein networkhttps://string-db.org/network/83332.Rv3706cRv3706c, (MTV025.054c), len: 106 aa. Conserved ypothetical pro-rich protein, similar to upstream ORF Rv3705A (129 aa), and AAK48176|MT3808.1 hypothetical 13.0 KDA protein from Mycobacterium tuber [...]
Rv3707c protein networkhttps://string-db.org/network/83332.Rv3707cConserved hypothetical protein; Rv3707c, (MTV025.055c), len: 336 aa. Equivalent to Q9CB79|ML2321 hypothetical protein from Mycobacterium leprae (336 aa), FASTA scores: opt: 1948, E(): 6.7e-110,(8 [...]
asd protein networkhttps://string-db.org/network/83332.Rv3708cAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate. Is essential for [...]
ask protein networkhttps://string-db.org/network/83332.Rv3709cAspartokinase Ask (aspartate kinase) [contains: aspartokinase alpha subunit (Ask-alpha); Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-as [...]
leuA protein networkhttps://string-db.org/network/83332.Rv37102-isopropylmalate synthase LeuA (alpha-isopropylmalate synthase) (alpha-IPM synthetase) (IPMS); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoiso [...]
dnaQ protein networkhttps://string-db.org/network/83332.Rv3711cRv3711c, (MTV025.059c), len: 329 aa. Probable dnaQ,DNA polymerase III, epsilon subunit, similar to many e.g. Q9RJ41|SCI8.12 from Streptomyces coelicolor (328 aa), FASTA scores: opt: 509, E(): 4.2 [...]
Rv3712 protein networkhttps://string-db.org/network/83332.Rv3712Possible ligase; Rv3712, (MTV025.060), len: 413 aa. Possible ligase, equivalent to O69522|ML2326|MLCB2407.24c hypothetical 43.8 KDA protein (possible ligase) from Mycobacterium leprae (411 aa), F [...]
cobQ2 protein networkhttps://string-db.org/network/83332.Rv3713Rv3713, (MTV025.061), len: 231 aa. Possible cobQ2,cobyric acid synthase, equivalent to O69521|ML2327|MLCB2407.23c hypothetical 24.5 KDA protein from Mycobacterium leprae (230 aa), FASTA scores: o [...]
Rv3714c protein networkhttps://string-db.org/network/83332.Rv3714cRv3714c, (MTV025.062c), len: 296 aa. Conserved hypothetical protein, highly similar to O07396|MAV346 MAV346 protein from Mycobacterium avium (346 aa) FASTA scores: opt: 834, E(): 2.2e-46, (50.0% [...]
recR protein networkhttps://string-db.org/network/83332.Rv3715cProbable recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Rv3716c protein networkhttps://string-db.org/network/83332.Rv3716cConserved protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Rv3717 protein networkhttps://string-db.org/network/83332.Rv3717Conserved hypothetical protein; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to hydrolyze the cell walls of s [...]
Rv3718c protein networkhttps://string-db.org/network/83332.Rv3718cConserved protein; Rv3718c, (MTV025.066c), len: 147 aa. Conserved protein, equivalent to O69517|ML2332|MLCB2407.18 hypothetical 15.5 KDA protein from Mycobacterium leprae (145 aa), FASTA scores: [...]
Rv3719 protein networkhttps://string-db.org/network/83332.Rv3719Conserved protein; Rv3719, (MTV025.067), len: 470 aa. Conserved protein, equivalent to O69516|ML2333|MLCB2407.17c hypothetical 51.8 KDA protein from Mycobacterium leprae (459 aa), FASTA scores: o [...]
Rv3720 protein networkhttps://string-db.org/network/83332.Rv3720Possible fatty acid synthase; May be a S-adenosylmethionine-dependent methyltransferase involved in fatty acid metabolism.
dnaZX protein networkhttps://string-db.org/network/83332.Rv3721cDNA polymerase III (subunit gamma/tau) DnaZ/X; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits [...]
Rv3722c protein networkhttps://string-db.org/network/83332.Rv3722cConserved protein; Rv3722c, (MTV025.070c), len: 435 aa. Conserved protein, equivalent to O69513|MLCB2407.14 (alias Q9CB73|ML2336, 463 aa) hypothetical 46.8 KDA protein from Mycobacterium leprae ( [...]
lucA protein networkhttps://string-db.org/network/83332.Rv3723Probable conserved transmembrane protein; Required for the import of both fatty acids and cholesterol during growth in macrophages and in axenic culture. Facilitates the uptake of these lipids by [...]
cut5a protein networkhttps://string-db.org/network/83332.Rv3724ARv3724A, (MTV025.072), len: 80 aa. Probable cut5a,truncated cutinase precursor, similar to N-terminal end of others e.g. Q9KK87 serine esterase cutinase from Mycobacterium avium (220 aa), FASTA s [...]
cut5b protein networkhttps://string-db.org/network/83332.Rv3724BRv3724B, (MTV025.072), len: 187 aa. Probable cut5b,truncated cutinase, similar to C-terminal end of others e.g. Q9XB09|RVD2-RV1758 protein (fragment) from Mycobacterium bovis BCG (143 aa) FASTA s [...]
Rv3725 protein networkhttps://string-db.org/network/83332.Rv3725Rv3725, (MTV025.073), len: 309 aa. Possible reductase, similar to various oxidoreductases and hypothetical proteins e.g. O34285|HPNA HPNA protein from Zymomonas mobilis (337 aa), FASTA scores: op [...]
Rv3726 protein networkhttps://string-db.org/network/83332.Rv3726Rv3726, (MTV025.074), len: 397 aa. Possible dehydrogenase, similar to many e.g. O34788|YDJL dehydrogenase from Bacillus subtilis (346 aa) FASTA scores: opt: 401, E(): 3.4e-17, (29.6% identity in [...]
Rv3727 protein networkhttps://string-db.org/network/83332.Rv3727Rv3727, (MTV025.075), len: 602 aa. Possible oxidoreductase, similar to several plants phytoene dehydrogenases/desaturases e.g. Q9HSE1|CRTI3|VNG0277G phytoene dehydrogenase from Halobacterium sp. [...]
Rv3728 protein networkhttps://string-db.org/network/83332.Rv3728Rv3728, (MTV025.076), len: 1065 aa. Probable conserved transmembrane protein organised into two domains. Domain comprising the first ~510 aa residues is similar to various multidrug resistance an [...]
Rv3729 protein networkhttps://string-db.org/network/83332.Rv3729Possible transferase; Rv3729, (MTV025.077), len: 776 aa. Conserved hypothetical protein, possible transferase, similar to several hypothetical proteins and various transferases e.g. O26919|MTH831 [...]
Rv3730c protein networkhttps://string-db.org/network/83332.Rv3730cRv3730c, (MTV025.078c), len: 346 aa. Conserved hypothetical protein, highly similar to Q9XAM1|SC4C6.19 hypothetical 38.5 KDA protein from Streptomyces coelicolor (341 aa), FASTA scores: opt: 1313 [...]
ligC protein networkhttps://string-db.org/network/83332.Rv3731DNA ligase C; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
Rv3732 protein networkhttps://string-db.org/network/83332.Rv3732Conserved protein; Rv3732, (MTV025.080), len: 352 aa. Conserved protein. The region between aa 175-352 is highly similar to the region between aa 72-257 of Q9KH39 hypothetical 55.5 KDA protein fr [...]
Rv3733c protein networkhttps://string-db.org/network/83332.Rv3733cRv3733c, (MTV025.081c), len: 166 aa. Conserved hypothetical protein, highly similar to Q9FCB0|2SCG58.03 putative mutt-like protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 541, E [...]
tgs2 protein networkhttps://string-db.org/network/83332.Rv3734cPutative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as [...]
Rv3735 protein networkhttps://string-db.org/network/83332.Rv3735Rv3735, (MTV025.083), len: 162 aa. Conserved hypothetical protein, highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus [...]
Rv3736 protein networkhttps://string-db.org/network/83332.Rv3736Transcriptional regulatory protein (probably AraC/XylS-family); Rv3736, (MTV025.084), len: 353 aa. Probable transcriptional regulator, araC/xylS family, similar to many transcriptional regulators [...]
Rv3737 protein networkhttps://string-db.org/network/83332.Rv3737Rv3737, (MTV025.085), len: 529 aa. Probable conserved transmembrane protein, similar to others and also some hypothetical proteins e.g. AAK61331|THRE threonine export carrier from Corynebacterium [...]
PPE66 protein networkhttps://string-db.org/network/83332.Rv3738cRv3738c, (MTV025.086c), len: 315 aa. PPE66, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. O53265|Rv3018c|MTV012.32c (434 aa),FASTA scores: opt: 464, E(): 2.2e-1 [...]
PPE67 protein networkhttps://string-db.org/network/83332.Rv3739cRv3739c, (MTV025.087c), len: 77 aa. PPE67, Member of the Mycobacterium tuberculosis PE family, showing high homology with O53269|Rv3022c|MTV012.36c (82 aa) FASTA scores: opt: 398, E(): 1.2e-19, ( [...]
Rv3740c protein networkhttps://string-db.org/network/83332.Rv3740cPossible triacylglycerol synthase (diacylglycerol acyltransferase); Upon expression in E.coli has a weak triacylglycerol synthase function, making triacylglycerol (TG) from diolein and long-chain [...]
Rv3741c protein networkhttps://string-db.org/network/83332.Rv3741cRv3741c, (MTV025.089c), len: 224 aa. Possible oxidoreductase, probably combines with product of upstream ORF MTV025.090c to form a functional monooxygenase, highly similar to C-terminal end of va [...]
Rv3742c protein networkhttps://string-db.org/network/83332.Rv3742cRv3742c, (MTV025.090c), len: 131 aa. Possible oxidoreductase, probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase, highly similar to N-terminal end of [...]
ctpJ protein networkhttps://string-db.org/network/83332.Rv3743cRv3743c, (MTV025.091c), len: 660 aa. Probable ctpJ,cation-transporting P-type ATPase, transmembrane protein highly similar to others e.g. Q9ZBF3|SC9B5.27 putative cation-transporting ATPase from [...]
nmtR protein networkhttps://string-db.org/network/83332.Rv3744Metal sensor transcriptional regulator (ArsR-SmtB family); Represses transcription of ctpJ/nmtA, by binding to its promoter region.
Rv3745c protein networkhttps://string-db.org/network/83332.Rv3745cRv3745c, (MTV025.093c), len: 70 aa. Conserved hypothetical protein, highly similar to others e.g. N-terminus of Q9X4E6 hypothetical 13.4 KDA protein from Rhodobacter sphaeroides (Rhodopseudomonas [...]
PE34 protein networkhttps://string-db.org/network/83332.Rv3746cRv3746c, (MTV025.094c), len: 111 aa. PE34, Probable member of the Mycobacterium tuberculosis PE family (see citation below), but without the glycine-rich C-terminal part, similar to N-termini of [...]
Rv3747 protein networkhttps://string-db.org/network/83332.Rv3747Conserved protein; Rv3747, (MTV025.095), len: 127 aa. Conserved protein, highly similar to downstream ORF O69715|Rv3748|MTV025.096 conserved hypothetical protein (119 aa), FASTA scores: opt: 494, [...]
Rv3748 protein networkhttps://string-db.org/network/83332.Rv3748Rv3748, (MTV025.096), len: 119 aa. Hypothetical protein, highly similar to upstream ORF O69714|Rv3747|MTV025.095 conserved hypothetical protein (127 aa), FASTA scores: opt: 496, E(): 2.5e-28, (64 [...]
vapC50 protein networkhttps://string-db.org/network/83332.Rv3749cConserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. The cognate antitoxin is VapB50.
vapB50 protein networkhttps://string-db.org/network/83332.Rv3750cPossible excisionase; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC50.
Rv3751 protein networkhttps://string-db.org/network/83332.Rv3751Rv3751, (MTV025.099), len: 71 aa. Probable integrase (fragment), similar to part of many e.g. Q48908 integrase (fragment) from Mycobacterium paratuberculosis (191 aa),FASTA scores: opt: 206, E(): [...]
tadA protein networkhttps://string-db.org/network/83332.Rv3752cPossible cytidine/deoxycytidylate deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase famil [...]
Rv3753c protein networkhttps://string-db.org/network/83332.Rv3753cConserved protein; Rv3753c, (MTV025.101c), len: 166 aa. Conserved protein, only equivalent to Q9CB33|ML2473 hypothetical protein from Mycobacterium leprae (159 aa) FASTA scores: opt: 920 E(): 1.4 [...]
tyrA protein networkhttps://string-db.org/network/83332.Rv3754Prephenate dehydrogenase TyrA (PDH) (hydroxyphenylpyruvate synthase); Catalyzes the NAD(+)-dependent conversion of prephenate to p- hydroxyphenylpyruvate, with the elimination of carbon dioxide. [...]
Rv3755c protein networkhttps://string-db.org/network/83332.Rv3755cConserved protein; Rv3755c, (MTV025.103c), len: 199 aa. Conserved protein showing similarity to CAC47343|SMC03980 conserved hypothetical protein from Rhizobium meliloti (Sinorhizobium meliloti) ( [...]
proZ protein networkhttps://string-db.org/network/83332.Rv3756cRv3756c, (MTV025.104c), len: 239 aa. Possible proZ,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involve [...]
proW protein networkhttps://string-db.org/network/83332.Rv3757cRv3757c, (MTV025.105c), len: 229 aa. Possible proW,osmoprotectant transport integral membrane protein ABC transporter (see citation below), similar to osmoprotection proteins (proW, proZ) involve [...]
proV protein networkhttps://string-db.org/network/83332.Rv3758cRv3758c, (MTV025.106c), len: 376 aa. Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in [...]
proX protein networkhttps://string-db.org/network/83332.Rv3759cRv3759c, (MTV025.107c), len: 315 aa. Possible proX,osmoprotectant-binding lipoprotein component of osmoprotectant transport system (see citation below),similar to osmoprotection proteins (proX) i [...]
Rv3760 protein networkhttps://string-db.org/network/83332.Rv3760Rv3760, (MTV025.108), len: 100 aa. Possible conserved membrane protein, equivalent to Q50094|ML2366|MLCB12.11c putative membrane protein from Mycobacterium leprae (113 aa), FASTA scores: opt: 423 [...]
fadE36 protein networkhttps://string-db.org/network/83332.Rv3761cRv3761c, (MTV025.109c), len: 351 aa. Possible fadE36, acyl-CoA dehydrogenase, similar to many conserved hypothetical proteins and showing some similarity with few acyl-CoA dehydrogenases, e.g. Q9 [...]
Rv3762c protein networkhttps://string-db.org/network/83332.Rv3762cPossible hydrolase; Rv3762c, (MTV025.110c), len: 626 aa. Possible hydrolase, highly similar to hypothetical proteins and beta-lactamases e.g. Q9RL04|SC5G9.23 hypothetical 70.3 KDA protein from St [...]
lpqH protein networkhttps://string-db.org/network/83332.Rv376319 kDa lipoprotein antigen precursor LpqH; Based on its structure might be involved in ligand transport (By similarity); Belongs to the mycobacterial 19 kDa antigen family.
tcrY protein networkhttps://string-db.org/network/83332.Rv3764cPossible two component sensor kinase TcrY; Member of the two-component regulatory system TcrY/TcrX. Activates TcrX by phosphorylation.
tcrX protein networkhttps://string-db.org/network/83332.Rv3765cProbable two component transcriptional regulatory protein TcrX; Member of the two-component regulatory system TcrY/TcrX.
Rv3766 protein networkhttps://string-db.org/network/83332.Rv3766Hypothetical protein; Rv3766, (MTV025.114), len: 229 aa. Hypothetical unknown protein. Segment 183 to 229 highly similar to C-terminal part of O06288|Rv3594|MTCY07H7B.28c conserved hypothetical p [...]
Rv3767c protein networkhttps://string-db.org/network/83332.Rv3767cPossible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv3768 protein networkhttps://string-db.org/network/83332.Rv3768Unknown protein; Rv3768, (MTCY13D12.02), len: 119 aa. Unknown protein.
Rv3769 protein networkhttps://string-db.org/network/83332.Rv3769Hypothetical protein; Rv3769, (MTCY13D12.03), len: 90 aa. Hypothetical unknown protein, possible coiled-coil protein.
Rv3770A protein networkhttps://string-db.org/network/83332.Rv3770ARv3770A, len: 60 aa. Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: [...]
Rv3770B protein networkhttps://string-db.org/network/83332.Rv3770BRv3770B, len: 63 aa. Probable remnant of a transposase, similar to many e.g. Rv2812|MTCY16B7.31c|Z81331_17 IS1604 putative transposase from Mycobacterium tuberculosis (469 aa), FASTA scores: opt: [...]
Rv3770c protein networkhttps://string-db.org/network/83332.Rv3770cHypothetical leucine rich protein; Rv3770c, (MTCY13D12.04c), len: 191 aa. Hypothetical unknown leu-rich protein.
Rv3771c protein networkhttps://string-db.org/network/83332.Rv3771cRv3771c, (MTCY13D12.05c), len: 108 aa. Hypothetical protein, highly similar, but shorter 81 aa, to P71640|Rv2811|MTCY16B7.32c hypothetical 21.1 KDA protein from Mycobacterium tuberculosis (202 aa [...]
hisC2 protein networkhttps://string-db.org/network/83332.Rv3772Putative phenylalanine aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Rv3773c protein networkhttps://string-db.org/network/83332.Rv3773cConserved protein; Rv3773c, (MTCY13D12.07c), len: 194 aa. Conserved protein, highly similar to C-terminal end of O53773|Rv0576|MTV039.14 possible transcriptional regulator from Mycobacterium tube [...]
echA21 protein networkhttps://string-db.org/network/83332.Rv3774Possible enoyl-CoA hydratase EchA21 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv3774, (MTCY13D12.08), len: 274 aa. Possible echA21, enoyl-CoA hydratase, equivalent to Q9CD94|E [...]
lipE protein networkhttps://string-db.org/network/83332.Rv3775Probable lipase LipE; Rv3775, (MTCY13D12.09), len: 415 aa. Probable lipE,hydrolase lipase, equivalent to Q9CD95|LIPE|ML0119 probable hydrolase from Mycobacterium leprae (411 aa), FASTA scores: op [...]
Rv3776 protein networkhttps://string-db.org/network/83332.Rv3776Rv3776, (MTCY13D12.10), len: 519 aa. Conserved hypothetical protein, highly similar to Q10709|YL00_MYCTU|Rv2100|MTCY49.40 hypothetical 58.9 KDA protein from Mycobacterium tuberculosis (550 aa) FA [...]
Rv3777 protein networkhttps://string-db.org/network/83332.Rv3777Rv3777, (MTCY13D12.11), len: 328 aa. Probable oxidoreductase, equivalent to Q9CD96|ML0118 putative oxidoreductase from Mycobacterium leprae (336 aa) FASTA scores: opt: 1661, E(): 1.1e-87, (76.0% [...]
Rv3778c protein networkhttps://string-db.org/network/83332.Rv3778cPossible aminotransferase; Is essential for optimal growth; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.
Rv3779 protein networkhttps://string-db.org/network/83332.Rv3779Probable conserved transmembrane protein alanine and leucine rich; Rv3779, (MTCY13D12.13), len: 666 aa. Predicted to be in the GT-C superfamily of glycosyltransferases (See Liu and Mushegian, 200 [...]
bpa protein networkhttps://string-db.org/network/83332.Rv3780Conserved protein; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates prot [...]
rfbE protein networkhttps://string-db.org/network/83332.Rv3781Rv3781, (MTCY13D12.15), len: 273 aa. Probable rfbE,polysaccharide-transport ATP-binding protein ABC transporter, involved in O-antigen/lipopolysaccharides (LPS) transport (see Braibant et al., 20 [...]
glfT1 protein networkhttps://string-db.org/network/83332.Rv3782UDP-galactofuranosyl transferase GlfT1; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the m [...]
rfbD protein networkhttps://string-db.org/network/83332.Rv3783Rv3783, (MTCY13D12.17), len: 280 aa. Probable rfbD,polysaccharide-transport integral membrane protein ABC transporter (see Braibant et al., 2000), involved in O-antigen/lipopolysaccharides (LPS) [...]
Rv3784 protein networkhttps://string-db.org/network/83332.Rv3784Rv3784, (MTCY13D12.18), len: 326 aa. Possible dTDP-glucose 4,6-dehydratase, but experimental study shown that the purified protein didn't have dTDP-glucose dehydratase (rmlB) activity (see citati [...]
Rv3785 protein networkhttps://string-db.org/network/83332.Rv3785Hypothetical protein; Rv3785, (MTCY13D12.19), len: 357 aa. Hypothetical unknown protein. Note that this putative protein is equivalent to AAK48258|MT3893 NAD-dependent epimerase/dehydratase famil [...]
Rv3786c protein networkhttps://string-db.org/network/83332.Rv3786cUnknown protein; Rv3786c, (MTCY13D12.20), len: 407 aa. Unknown protein. Segment between aa 265-300 (approximately) is highly similar to part of O03937|RORF1608 minor capsid protein from Bacteriop [...]
Rv3787c protein networkhttps://string-db.org/network/83332.Rv3787cConserved hypothetical protein; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Rv3788 protein networkhttps://string-db.org/network/83332.Rv3788Hypothetical protein; Rv3788, (MTCY13D12.22), len: 161 aa. Hypothetical unknown protein.
Rv3789 protein networkhttps://string-db.org/network/83332.Rv3789GTRA family protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first ara [...]
dprE1 protein networkhttps://string-db.org/network/83332.Rv3790Decaprenylphosphoryl-beta-D-ribose 2'-oxidase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-arabinose (D [...]
dprE2 protein networkhttps://string-db.org/network/83332.Rv3791Decaprenylphosphoryl-D-2-keto erythro pentose reductase; Component of the DprE1-DprE2 complex that catalyzes the 2- step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl- phospho-ar [...]
aftA protein networkhttps://string-db.org/network/83332.Rv3792Arabinofuranosyltransferase AftA; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobac [...]
embC protein networkhttps://string-db.org/network/83332.Rv3793Probable arabinosyltransferase C; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
embA protein networkhttps://string-db.org/network/83332.Rv3794Probable arabinosyltransferase A; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.
embB protein networkhttps://string-db.org/network/83332.Rv3795Probable arabinosyltransferase B; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
Rv3796 protein networkhttps://string-db.org/network/83332.Rv3796Conserved protein; Rv3796, (MTV026.01-MTCY13D12.30), len: 375 aa. Conserved protein. C-terminal end similar in part to Q983J3|MLR8305 hypothetical protein from Rhizobium loti (Mesorhizobium loti) [...]
fadE35 protein networkhttps://string-db.org/network/83332.Rv3797Rv3797, (MTV026.02), len: 593 aa. Probable fadE35,acyl-CoA dehydrogenase, similar to many e.g. Q9HY33|PA3593 from Pseudomonas aeruginosa (575 aa) FASTA scores: opt: 838, E(): 2.1e-46, (35.3% iden [...]
Rv3798 protein networkhttps://string-db.org/network/83332.Rv3798Probable transposase; Rv3798, (MTV026.03), len: 444 aa. Probable transposase for insertion sequence element IS1557, highly similar to Q60255 similar to transposase of ISAE1 from alcaligenes eutro [...]
accD4 protein networkhttps://string-db.org/network/83332.Rv3799cRv3799c, (MTV026.04c), len: 522 aa. Probable accD4,propionyl-CoA carboxylase beta chain 4, equivalent to Q9CDB0|ACCD4|ML0102 putative acyl CoA carboxylase from Mycobacterium leprae (517 aa) FASTA [...]
pks13 protein networkhttps://string-db.org/network/83332.Rv3800cPolyketide synthase Pks13; Rv3800c, (MTV026.05c), len: 1733 aa. Probable pks13,polyketide synthase, equivalent to Q9CDB1|PKS13|ML0101 polyketide synthase from Mycobacterium leprae (1784 aa),FASTA [...]
fadD32 protein networkhttps://string-db.org/network/83332.Rv3801cLong-chain-fatty-acid--AMP ligase FadD32; Catalyzes the activation of long-chain fatty acids as acyl- adenylates (acyl-AMP), which are then transferred to the multifunctional polyketide synthase [...]
Rv3802c protein networkhttps://string-db.org/network/83332.Rv3802cRv3802c, (MTV026.07c), len: 336 aa. Probable conserved membrane protein, with a N-terminal signal sequence followed by Pro-rich region. Equivalent to Q9CDB3|ML0099 hypothetical protein from Mycob [...]
fbpD protein networkhttps://string-db.org/network/83332.Rv3803cMPT51/MPB51 antigen; May have a role in host tissue attachment, whereby ligands may include the serum protein fibronectin and small sugars.
fbpA protein networkhttps://string-db.org/network/83332.Rv3804cDiacylglycerol acyltransferase/mycolyltransferase Ag85A; The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria for fibronectin, a large adhesive glycopr [...]
aftB protein networkhttps://string-db.org/network/83332.Rv3805cPossible arabinofuranosyltransferase AftB; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of th [...]
ubiA protein networkhttps://string-db.org/network/83332.Rv3806cDecaprenyl-phosphate phosphoribosyltransferase; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Ca [...]
Rv3807c protein networkhttps://string-db.org/network/83332.Rv3807cPossible conserved transmembrane protein; Involved in the biosynthesis of decaprenylphosphoryl arabinose (DPA) a precursor for arabinan synthesis in mycobacterial cell wall biosynthesis. Could be [...]
glfT2 protein networkhttps://string-db.org/network/83332.Rv3808cBifunctional UDP-galactofuranosyl transferase GlfT2; Involved in the galactan polymerization of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an esse [...]
glf protein networkhttps://string-db.org/network/83332.Rv3809cUDP-galactopyranose mutase; Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a [...]
pirG protein networkhttps://string-db.org/network/83332.Rv3810Exported repetitive protein precursor PirG (cell surface protein) (EXP53); Surface-exposed protein required for multiplication and intracellular growth; To M.leprae 28 kDa antigen.
Rv3811 protein networkhttps://string-db.org/network/83332.Rv3811Rv3811, (MTV026.16), len: 539 aa. Conserved hypothetical protein, showing some similarity to Q9KZK5|SCE34.21c putative secreted protein from Streptomyces coelicolor (416 aa), FASTA scores: opt: 6 [...]
PE_PGRS62 protein networkhttps://string-db.org/network/83332.Rv3812PE-PGRS family protein PE_PGRS62; Rv3812, (MTV026.17, MTCY409.18c), len: 504 aa. PE_PGRS62, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citations [...]
Rv3813c protein networkhttps://string-db.org/network/83332.Rv3813cConserved protein; Rv3813c, (MTCY409.17), len: 273 aa. Conserved protein, equivalent to Q9CDB9|ML0089 hypothetical protein from Mycobacterium leprae (281 aa) FASTA scores: opt: 1479,E(): 9.6e-81, [...]
Rv3814c protein networkhttps://string-db.org/network/83332.Rv3814cRv3814c, (MTCY409.16), len: 261 aa. Possible acyltransferase, highly similar to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa), FASTA scores: opt: 753, E(): 7.7e-42, (4 [...]
Rv3815c protein networkhttps://string-db.org/network/83332.Rv3815cRv3815c, (MTCY409.15), len: 251 aa. Possible acyltransferase, highly similar to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa), FASTA scores: opt: 845, E(): 2.7e-47, (5 [...]
Rv3816c protein networkhttps://string-db.org/network/83332.Rv3816cRv3816c, (MTCY409.14), len: 259 aa. Possible acyltransferase, equivalent to Q9CDC0|ML0087 putative acyltransferase from Mycobacterium leprae (257 aa) FASTA scores: opt: 1401, E(): 1.5e-80, (81.9% [...]
Rv3817 protein networkhttps://string-db.org/network/83332.Rv3817Rv3817, (MTCY409.13c), len: 251 aa. Possible phosphotransferase, similar to many phosphotransferases e.g. O53023 kanamycin marker from Escherichia coli (264 aa), FASTA scores: opt: 232, E(): 7.5e [...]
Rv3818 protein networkhttps://string-db.org/network/83332.Rv3818Unknown protein; Rv3818, (MTCY409.12c), len: 516 aa. Unknown protein.
Rv3819 protein networkhttps://string-db.org/network/83332.Rv3819Unknown protein; Rv3819, (MTCY409.11c), len: 111 aa. Unknown protein. Contains PS00012 Phosphopantetheine attachment site.
papA2 protein networkhttps://string-db.org/network/83332.Rv3820cPossible conserved polyketide synthase associated protein PapA2; Catalyzes the acylation of trehalose-2-sulfate by adding the palmitoyl group at the 2'-position to yield the intermediate trehalos [...]
sap protein networkhttps://string-db.org/network/83332.Rv3821Probable conserved integral membrane protein; Required for the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogenic mycobacteria. Could also [...]
chp1 protein networkhttps://string-db.org/network/83332.Rv3822Conserved hypothetical protein; Involved in the final steps of the cell wall sulfolipid-1 (SL-1) biosynthesis. Catalyzes two successive acylations of the precursor 2-palmitoyl-3-(C43)-phthioceran [...]
mmpL8 protein networkhttps://string-db.org/network/83332.Rv3823cConserved integral membrane transport protein MmpL8; Required for the biosynthesis and the transport across the inner membrane of sulfolipid-1 (SL-1), which is a major cell wall lipid of pathogen [...]
papA1 protein networkhttps://string-db.org/network/83332.Rv3824cConserved polyketide synthase associated protein PapA1; Catalyzes the acylation of trehalose-2-sulfate-2'-palmitate (SL659) by adding the (hydroxy)phthioceranoyl group at the 3'-position to yield [...]
pks2 protein networkhttps://string-db.org/network/83332.Rv3825cPolyketide synthase Pks2; Catalyzes the synthesis of the hepta- and octamethyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids.
fadD23 protein networkhttps://string-db.org/network/83332.Rv3826Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase); Catalyzes the activation of long-chain fatty acids as acyl- coenzyme A (acyl-CoA), which are then tran [...]
Rv3827c protein networkhttps://string-db.org/network/83332.Rv3827cPossible transposase; Rv3827c, (MTCY409.03), len: 408 aa. Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 tr [...]
Rv3828c protein networkhttps://string-db.org/network/83332.Rv3828cPossible resolvase; Rv3828c, (MTCY409.02), len: 203 aa. Possible resolvase within IS1537 element, similar to others e.g. Q97X40|SSO1915 first ORF in transposon ISC1913 from Sulfolobus solfataricu [...]
Rv3829c protein networkhttps://string-db.org/network/83332.Rv3829cProbable dehydrogenase; Rv3829c, (MTCY409.01, MTCY01A6.40), len: 536 aa. Probable oxidoreductase dehydrogenase, similar to others e.g. Q9A3T1|CC3121 phytoene dehydrogenase-related protein from Ca [...]
Rv3830c protein networkhttps://string-db.org/network/83332.Rv3830cTranscriptional regulatory protein (probably TetR-family); Rv3830c, (MTCY01A6.39), len: 209 aa. Probable transcriptional regulator TetR family, similar to others e.g. P39885|TCMR_STRGA tetracenom [...]
Rv3831 protein networkhttps://string-db.org/network/83332.Rv3831Hypothetical protein; Rv3831, (MTCY01A6.38c), len: 160 aa. Hypothetical unknown protein.
Rv3832c protein networkhttps://string-db.org/network/83332.Rv3832cConserved protein; Rv3832c, (MTCY01A6.37), len: 191 aa. Conserved protein, similar in part to various proteins e.g. Q9XBC9|CZA382.22c putative rRNA methylase from Amycolatopsis orientalis (259 aa [...]
Rv3833 protein networkhttps://string-db.org/network/83332.Rv3833Transcriptional regulatory protein (probably AraC-family); Rv3833, (MTCY01A6.36c), len: 263 aa. Probable transcriptional regulator belonging to araC family, similar to others e.g. Q9KYN4|SC9H11.0 [...]
serS protein networkhttps://string-db.org/network/83332.Rv3834cSERYL-tRNA synthetase SerS (serine--tRNA ligase) (SERRS) (serine translase); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misac [...]
Rv3835 protein networkhttps://string-db.org/network/83332.Rv3835Conserved membrane protein; May play a role in septum formation.
Rv3836 protein networkhttps://string-db.org/network/83332.Rv3836Rv3836, (MTCY01A6.33c), len: 137 aa. Conserved hypothetical protein, highly similar to Q9RKJ2|SCD25.30 hypothetical 13.1 KDA protein from Streptomyces coelicolor (116 aa), FASTA scores: opt: 395, [...]
Rv3837c protein networkhttps://string-db.org/network/83332.Rv3837cRv3837c, (MTCY01A6.32), len: 232 aa. Probable phosphoglycerate mutase, equivalent to Q9CDC3|ML0079 putative phosphoglycerate mutase from Mycobacterium leprae (231 aa), FASTA scores: opt: 1116, E( [...]
pheA protein networkhttps://string-db.org/network/83332.Rv3838cRv3838c, (MTCY01A6.31), len: 321 aa. PheA,prephenate dehydratase (see citation below), equivalent to Q9CDC4|PHEA|ML0078 putative prephenate dehydratase from Mycobacterium leprae (322 aa), FASTA s [...]
Rv3839 protein networkhttps://string-db.org/network/83332.Rv3839Rv3839, (MTCY01A6.30c), len: 258 aa. Conserved hypothetical protein, similar in part to Q9RD78|SCF43.10cfrom hypothetical 25.8 KDA protein Streptomyces coelicolor (241 aa), FASTA scores: opt: 270 [...]
Rv3840 protein networkhttps://string-db.org/network/83332.Rv3840Rv3840, (MTCY01A6.29c), len: 137 aa. Possible transcriptional regulator, highly similar in part to PSR proteins (penicillin binding protein repressors) e.g. Q47828|PSR PSR protein from Enterococc [...]
bfrB protein networkhttps://string-db.org/network/83332.Rv3841Bacterioferritin BfrB; Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe(2+) ions into Fe(3+) ions, that can then be deposited as a ferric-oxide mineral core [...]
glpQ1 protein networkhttps://string-db.org/network/83332.Rv3842cProbable glycerophosphodiester phosphodiesterase 1; Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
Rv3843c protein networkhttps://string-db.org/network/83332.Rv3843cRv3843c, (MTCY01A6.26), len: 342 aa. Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 putative membrane protein from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E [...]
Rv3844 protein networkhttps://string-db.org/network/83332.Rv3844Possible transposase; Rv3844, (MTCY01A6.25), len: 163 aa. Possible transposase, identical to P96234|Rv3348|MTV004.04 putative transposase from Mycobacterium tuberculosis. Also some similarity wit [...]
Rv3845 protein networkhttps://string-db.org/network/83332.Rv3845Hypothetical protein; Rv3845, (MTCY01A6.24c), len: 119 aa. Hypothetical unknown protein. Contains PS01137 Hypothetical YBL055c/yjjV family signature 1.
sodA protein networkhttps://string-db.org/network/83332.Rv3846Superoxide dismutase [FE] SodA; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Rv3847 protein networkhttps://string-db.org/network/83332.Rv3847Hypothetical protein; Rv3847, (MTCY01A6.21c), len: 177 aa. Conserved hypothetical protein, equivalent to Q9CDC7|ML0071 hypothetical protein from Mycobacterium leprae (177 aa) FASTA scores: opt: 1 [...]
Rv3848 protein networkhttps://string-db.org/network/83332.Rv3848Rv3848, (MTCY01A6.20c), len: 302 aa. Probable conserved transmembrane protein, similar to hypothetical (transmembrane) proteins e.g. Q9HVG2|PA4629 hypothetical protein from Pseudomonas aeruginosa [...]
espR protein networkhttps://string-db.org/network/83332.Rv3849ESX-1 transcriptional regulatory protein EspR; Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple ge [...]
Rv3850 protein networkhttps://string-db.org/network/83332.Rv3850Conserved protein; Rv3850, (MTCY01A6.18c), len: 218 aa. Conserved protein, equivalent to Q9CDD0|ML0068 hypothetical protein from Mycobacterium leprae (238 aa) FASTA scores: opt: 1071,E(): 7.2e-55 [...]
Rv3851 protein networkhttps://string-db.org/network/83332.Rv3851Possible membrane protein; Rv3851, (MTCY01A6.17c), len: 94 aa. Possible membrane protein.
hns protein networkhttps://string-db.org/network/83332.Rv3852Rv3852, (MTCY01A6.16c), len: 134 aa. Possible hns,histone-like protein, equivalent to Q9CDD1|HNS|ML0067 histone-like protein from Mycobacterium leprae (121 aa),FASTA scores: opt: 341, E(): 4.3e-0 [...]
rraA protein networkhttps://string-db.org/network/83332.Rv3853Regulator of RNase E activity a RraA; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxy [...]
ethA protein networkhttps://string-db.org/network/83332.Rv3854cMonooxygenase EthA; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones [...]
ethR protein networkhttps://string-db.org/network/83332.Rv3855Transcriptional regulatory repressor protein (TetR-family) EthR; Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide [...]
Rv3856c protein networkhttps://string-db.org/network/83332.Rv3856cRv3856c, (MTCY01A6.12), len: 335 aa. Conserved hypothetical protein, highly similar to various proteins from diverse organisms e.g. Q9EWR3|3SCF60.21 conserved hypothetical protein from Streptomyc [...]
Rv3857c protein networkhttps://string-db.org/network/83332.Rv3857cPossible membrane protein; Rv3857c, (MTCY01A6.11), len: 65 aa. Possible membrane protein.
gltD protein networkhttps://string-db.org/network/83332.Rv3858cGlutamate synthase [NADPH] small chain; Rv3858c, (MTCY01A6.10), len: 488 aa. Probable gltD,small subunit of NADH-dependent glutamate synthase,equivalent to Q9CDD4|GLTD|ML0062 NADH-dependent gluta [...]
gltB protein networkhttps://string-db.org/network/83332.Rv3859cGlutamate synthase [NADPH] large chain; Rv3859c, (MTCY01A6.09), len: 1527 aa. Probable gltB,ferredoxin-dependent glutamate synthase large subunit,equivalent to Q9CDD5|GLTB|ML0061 putative ferredo [...]
Rv3860 protein networkhttps://string-db.org/network/83332.Rv3860Conserved protein; Rv3860, (MTCY01A6.08c), len: 390 aa. Conserved protein, showing similarity with hypothetical proteins from Mycobacterium leprae e.g. Q9CDD8|ML0048 (586 aa), FASTA scores: opt: [...]
Rv3861 protein networkhttps://string-db.org/network/83332.Rv3861Hypothetical protein; Rv3861, (MTCY01A6.07c), len: 108 aa. Hypothetical unknown protein. Overlaps in part next ORF Rv3862c|whiB6.
whiB6 protein networkhttps://string-db.org/network/83332.Rv3862cPossible transcriptional regulatory protein WhiB-like WhiB6; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity). The ap [...]
Rv3863 protein networkhttps://string-db.org/network/83332.Rv3863Rv3863, (MTCY01A6.05c), len: 392 aa. Unknown ala-rich protein.
espE protein networkhttps://string-db.org/network/83332.Rv3864Rv3864, (MTCY01A6.04c), len: 402 aa. EspE, ESX-1 secretion-associated protein, similar to Q49722|ML0405|B1620_C2_213|MLCL383.01 hypothetical 40.8 KDA protein from Mycobacterium leprae (394 aa) FA [...]
espF protein networkhttps://string-db.org/network/83332.Rv3865Rv3865, (MTCY01A6.03c), len: 103 aa. EspF, ESX-1 secretion-associated protein, showing some similarity to O06268|Rv3615c|MTCY07H7B.07 hypothetical 10.8 KDA protein from Mycobacterium tuberculosis [...]
espG1 protein networkhttps://string-db.org/network/83332.Rv3866ESX-1 secretion-associated protein EspG1; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers. Belongs to the EspG family.
espH protein networkhttps://string-db.org/network/83332.Rv3867Rv3867, (MTV027.02), len: 183 aa. EspH, ESX-1 secretion-associated protein, highly similar to the hypothetical proteins from Mycobacterium leprae: Q9CDD6|ML0056 (169 aa) FASTA scores: opt: 403, E [...]
eccA1 protein networkhttps://string-db.org/network/83332.Rv3868ESX conserved component EccA1. ESX-1 type VII secretion system protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, in [...]
eccB1 protein networkhttps://string-db.org/network/83332.Rv3869ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence fact [...]
eccCa1 protein networkhttps://string-db.org/network/83332.Rv3870ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors [...]
eccCb1 protein networkhttps://string-db.org/network/83332.Rv3871ESX conserved component EccCb1. ESX-1 type VII secretion system protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, i [...]
PE35 protein networkhttps://string-db.org/network/83332.Rv3872PE family-related protein PE35; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PPE68, stimul [...]
PPE68 protein networkhttps://string-db.org/network/83332.Rv3873PPE family protein PPE68; Plays a major role in RD1-associated pathogenesis, and may contribute to the establishment and maintenance of M.tuberculosis infection. Together with PE35, stimulates th [...]
esxB protein networkhttps://string-db.org/network/83332.Rv387410 kDa culture filtrate antigen EsxB (LHP) (CFP10); A secreted protein. Acts as a strong host (human) T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to [...]
esxA protein networkhttps://string-db.org/network/83332.Rv38756 kDa early secretory antigenic target EsxA (ESAT-6); A secreted protein that plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacter [...]
espI protein networkhttps://string-db.org/network/83332.Rv3876ESX-1 secretion-associated protein EspI. Conserved proline and alanine rich protein; Required to repress ESX-1-mediated secretion under low ATP conditions. This function requires the ATP-binding [...]
eccD1 protein networkhttps://string-db.org/network/83332.Rv3877ESX-1 secretion system protein EccD1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors [...]
espJ protein networkhttps://string-db.org/network/83332.Rv3878ESX-1 secretion-associated protein EspJ. Conserved alanine rich protein; Could be involved in regulation of growth and intracellular survival.
espK protein networkhttps://string-db.org/network/83332.Rv3879cESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1.
espL protein networkhttps://string-db.org/network/83332.Rv3880cESX-1 secretion-associated protein EspL; Probably plays a role in host phagosome maturation arrest.
espB protein networkhttps://string-db.org/network/83332.Rv3881cSecreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form [...]
eccE1 protein networkhttps://string-db.org/network/83332.Rv3882cESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host [...]
mycP1 protein networkhttps://string-db.org/network/83332.Rv3883cMycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages a [...]
eccA2 protein networkhttps://string-db.org/network/83332.Rv3884cESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity).
eccE2 protein networkhttps://string-db.org/network/83332.Rv3885cRv3885c, (MTCY15F10.27), len: 537 aa. eccE2, esx conserved component, ESX-2 type VII secretion system protein. possible membrane protein (has hydrophobic stretch near N-terminus), showing some si [...]
mycP2 protein networkhttps://string-db.org/network/83332.Rv3886cMycosin-2; Rv3886c, (MTCY15F10.26), len: 550 aa. Probable mycP2, ala-, pro-rich membrane-anchored serine protease (mycosin) (see citation below), highly similar to Q9CBV3|ML1538 possible protease [...]
eccD2 protein networkhttps://string-db.org/network/83332.Rv3887cESX-2 secretion system protein eccD2; Rv3887c, (MTCY15F10.25), len: 509 aa. eccD2, esx conserved component, ESX-2 type VII secretion system protein, probable transmembrane protein (has hydrophili [...]
Rv3888c protein networkhttps://string-db.org/network/83332.Rv3888cRv3888c, (MTCY15F10.24), len: 341 aa. Probable conserved membrane protein, showing similarity with hypothetical proteins from Mycobacterium leprae: O33082|MLCB628.11c (478 aa), FASTA scores: opt: [...]
espG2 protein networkhttps://string-db.org/network/83332.Rv3889cESX-2 secretion-associated protein EspG2; Specific chaperone for cognate PE/PPE proteins. Plays an important role in preventing aggregation of PE/PPE dimers.
esxC protein networkhttps://string-db.org/network/83332.Rv3890cRv3890c, (MT4005, MTCY15F10.22), len: 95 aa. EsxC,ESAT-6 like protein (see Gey Van Pittius et al., 2001),equivalent to Q9K548|ES6B_MYCPA putative ESAT-6 like protein 11 (ORF3890C) from Mycobacter [...]
esxD protein networkhttps://string-db.org/network/83332.Rv3891cPossible ESAT-6 like protein EsxD; Rv3891c, (MTCY15F10.21), len: 107 aa (first GTG taken). EsxD, ESAT-6 like protein, equivalent to Q9K547 hypothetical 10.3 KDA protein (fragment) from Mycobacter [...]
PPE69 protein networkhttps://string-db.org/network/83332.Rv3892cRv3892c, (MTCY15F10.20), len: 399 aa. PPE69, Member of the Mycobacterium tuberculosis PPE family of conserved proteins, similar to many e.g. O05298|Rv1196|MTCI364.08 from Mycobacterium leprae (39 [...]
PE36 protein networkhttps://string-db.org/network/83332.Rv3893cRv3893c, (MTCY15F10.19), len: 77 aa. PE36, Member of the Mycobacterium tuberculosis PE family of conserved proteins (see citation below), similar to others e.g. O53690|Rv0285|MTV035.13 from Mycob [...]
eccC2 protein networkhttps://string-db.org/network/83332.Rv3894cRv3894c, (MTCY15F10.18), len: 1396 aa. EccC2, esx conserved component, ESX-2 type VII secretion system protein, possible membrane protein (possible transmembrane segments from aa ~37-85), similar [...]
eccB2 protein networkhttps://string-db.org/network/83332.Rv3895cESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity).
Rv3896c protein networkhttps://string-db.org/network/83332.Rv3896cConserved hypothetical protein; Rv3896c, (MTCY15F10.16), len: 302 aa (first GTG taken, although TBParse suggests TTG at 16079). Putative conserved ala-rich protein. C-terminus highly similar to C [...]
Rv3897c protein networkhttps://string-db.org/network/83332.Rv3897cRv3897c, (MTCY15F10.15), len: 210 aa. Conserved hypothetical protein, highly similar in part to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical 30.8 KDA protein from Mycobacterium tubercul [...]
Rv3898c protein networkhttps://string-db.org/network/83332.Rv3898cRv3898c, (MTCY15F10.14), len: 110 aa. Conserved hypothetical protein. Highly similar, but in part, to Q10691|YK83_MYCTU|Rv2083|MT2145|MTCY49.22 hypothetical 30.8 KDA protein from Mycobacterium tu [...]
Rv3899c protein networkhttps://string-db.org/network/83332.Rv3899cRv3899c, (MTCY15F10.13), len: 410 aa. Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly id [...]
Rv3900c protein networkhttps://string-db.org/network/83332.Rv3900cRv3900c, (MTCY15F10.12), len: 311 aa. Conserved hypothetical ala-rich protein, highly similar to N-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY49.21 hypothetical 73.6 KDA protein from Mycobacter [...]
Rv3901c protein networkhttps://string-db.org/network/83332.Rv3901cPossible membrane protein; Rv3901c, (MTCY15F10.11), len: 149 aa. Possible membrane protein (hydrophobic stretch from ~30-52), showing some similarity with O53200|Rv2473|MTV008.29 hypothetical 25. [...]
Rv3902c protein networkhttps://string-db.org/network/83332.Rv3902cHypothetical protein; Antitoxin for tuberculosis necrotizing toxin (TNT). Acts by binding directly to TNT, which inhibits NAD(+) glycohydrolase activity of TNT and protects M.tuberculosis from se [...]
cpnT protein networkhttps://string-db.org/network/83332.Rv3903cHypothetical alanine and proline rich protein; Has a dual function in uptake of nutrients and induction of host cell death. The N-terminal domain (NTD) forms an outer membrane channel and is used [...]
esxE protein networkhttps://string-db.org/network/83332.Rv3904cRv3904c, (MT4023, MTCY15F10.07), len: 90 aa. EsxE,ESAT-6 like protein, hypothetical unknown ala-rich protein. Belongs to the ESAT6 family (see citation below).
esxF protein networkhttps://string-db.org/network/83332.Rv3905cESAT-6-like protein EsxF; Rv3905c, (MT4024, MTCY15F10.06), len: 103 aa. EsxF,ESAT-6 like protein (see citation below), hypothetical unknown ala-, gly-rich protein, ESAT-6 like protein. Belongs to [...]
Rv3906c protein networkhttps://string-db.org/network/83332.Rv3906cRv3906c, (MTCY15F10.05), len: 169 aa. Conserved hypothetical protein, strongly related to Q50578|AT9S (sod related in Escherichia coli) from Mycobacterium tuberculosis strain aoyama B (155 aa), b [...]
pcnA protein networkhttps://string-db.org/network/83332.Rv3907cPoly(A) polymerase PcnA; Rv3907c, (MTCY15F10.04), len: 480 aa. Probable pcnA,polynucleotide polymerase, equivalent to Q9CCY1|PCNA|ML2697 PCNA protein from Mycobacterium leprae (486 aa), FASTA sco [...]
mutT4 protein networkhttps://string-db.org/network/83332.Rv3908Possible mutator protein MutT4; May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8-oxo- dGTP) from DNA and the nucleotid [...]
Rv3909 protein networkhttps://string-db.org/network/83332.Rv3909Conserved protein; Rv3909, (MTCY15F10.02c), len: 802 aa. Conserved protein, equivalent to Q9CCY0|ML2699 putative secreted protein from Mycobacterium leprae (797 aa) FASTA scores: opt: 3777, E(): [...]
mviN protein networkhttps://string-db.org/network/83332.Rv3910Probable conserved transmembrane protein; Essential for cell growth and peptidoglycan synthesis. In the N-terminal section; belongs to the MurJ/MviN family.
sigM protein networkhttps://string-db.org/network/83332.Rv3911Possible alternative RNA polymerase sigma factor SigM; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extra [...]
rsmA protein networkhttps://string-db.org/network/83332.Rv3912Hypothetical alanine rich protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigM. ECF sigma factors are held in an inactive form by an anti-sigma factor until release [...]
trxB2 protein networkhttps://string-db.org/network/83332.Rv3913Rv3913, (MT4032, MTV028.04), len: 335 aa. Probable trxB2, thioredoxin reductase (see citation below),equivalent to O30973|TRXB_MYCSM thioredoxin reductase from Mycobacterium smegmatis (311 aa), F [...]
trxC protein networkhttps://string-db.org/network/83332.Rv3914Thioredoxin TrxC (TRX) (MPT46); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange react [...]
cwlM protein networkhttps://string-db.org/network/83332.Rv3915Probable peptidoglycan hydrolase; Cell-wall hydrolase that hydrolyzes the amide bond between N- acetylmuramic acid and L-alanine in cell-wall glycopeptides. Is able to lyse whole mycobacteria, re [...]
Rv3916c protein networkhttps://string-db.org/network/83332.Rv3916cRv3916c, (MTV028.07c), len: 244 aa. Conserved hypothetical protein, equivalent to Q50200|ML2705|L222-ORF1 hypothetical protein from Mycobacterium leprae (259 aa),FASTA scores: opt: 1266, E(): 2e- [...]
parB protein networkhttps://string-db.org/network/83332.Rv3917cProbable chromosome partitioning protein ParB; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin [...]
parA protein networkhttps://string-db.org/network/83332.Rv3918cRv3918c, (MTV028.09c), len: 347 aa. Probable parA,chromosome partitioning protein, highly similar to Q9CCX7|para|ML2707 putative cell division protein from Mycobacterium leprae (351 aa), FASTA sc [...]
gid protein networkhttps://string-db.org/network/83332.Rv3919cProbable glucose-inhibited division protein B Gid; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
Rv3920c protein networkhttps://string-db.org/network/83332.Rv3920cRv3920c, (MTV028.11c), len: 187 aa. Conserved protein, similar to jag protein, equivalent to Q9L7M2 hypothetical 20.1 KDA protein from Mycobacterium paratuberculosis (183 aa), FASTA scores: opt: [...]
yidC protein networkhttps://string-db.org/network/83332.Rv3921cProbable conserved transmembrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of mem [...]
Rv3922c protein networkhttps://string-db.org/network/83332.Rv3922cPossible hemolysin; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.
rnpA protein networkhttps://string-db.org/network/83332.Rv3923cRibonuclease P protein component RnpA (RNaseP protein) (RNase P protein) (protein C5); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It c [...]
rpmH protein networkhttps://string-db.org/network/83332.Rv3924cRv3924c, (MTV028.15), len: 47 aa. rpmH, 50s ribosomal protein l34 (see citations below), equivalent to many mycobacterial 50S ribosomal protein L34 e.g. P46386|RL34_MYCLE|RPMH|ML2713 from Mycobac [...]