Organism Overview: Escherichia coli K12


 
thrL protein networkhttps://string-db.org/network/511145.b0001Thr operon leader peptide; This protein is involved in control of the biosynthesis of threonine.
thrA protein networkhttps://string-db.org/network/511145.b0002Bifunctional: aspartokinase I (N-terminal); homoserine dehydrogenase I (C-terminal); Protein involved in threonine biosynthetic process, methionine biosynthetic process and homoserine biosyntheti [...]
thrB protein networkhttps://string-db.org/network/511145.b0003Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs w [...]
thrC protein networkhttps://string-db.org/network/511145.b0004L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze [...]
yaaX protein networkhttps://string-db.org/network/511145.b0005DUF2502 family putative periplasmic protein; To E.coli YpeC.
yaaA protein networkhttps://string-db.org/network/511145.b0006Peroxide resistance protein, lowers intracellular iron; Involved in the cellular response to hydrogen peroxide (H(2)O(2)) stress. During H(2)O(2) stress, prevents oxidative damage to both DNA and [...]
yaaJ protein networkhttps://string-db.org/network/511145.b0007Putative transporter; Inner membrane transport protein.
talB protein networkhttps://string-db.org/network/511145.b0008Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
mog protein networkhttps://string-db.org/network/511145.b0009Molybdochelatase incorporating molybdenum into molybdopterin; Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor; Belongs to the MoaB/Mog family.
satP protein networkhttps://string-db.org/network/511145.b0010Succinate-acetate transporter; Uptake of acetate and succinate. Transport is energetically dependent on the protonmotive force.
yaaW protein networkhttps://string-db.org/network/511145.b0011UPF0174 family protein; Belongs to the UPF0174 family.
yaaI protein networkhttps://string-db.org/network/511145.b0013UPF0412 family protein; Belongs to the UPF0412 family.
dnaK protein networkhttps://string-db.org/network/511145.b0014Chaperone Hsp70, with co-chaperone DnaJ; Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lamb [...]
dnaJ protein networkhttps://string-db.org/network/511145.b0015Chaperone Hsp40, DnaK co-chaperone; Interacts with DnaK and GrpE to disassemble a protein complex at the origins of replication of phage lambda and several plasmids. Participates actively in the [...]
insL1 protein networkhttps://string-db.org/network/511145.b0016IS186 transposase; Involved in the transposition of the insertion sequence IS186.
mokC protein networkhttps://string-db.org/network/511145.b0018Regulatory protein for HokC, overlaps CDS of hokC; Might be the toxic component of a type I toxin-antitoxin (TA) system (By similarity). Regulatory peptide which completely overlaps hokC and enab [...]
nhaA protein networkhttps://string-db.org/network/511145.b0019Sodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 2 H(+) per Na(+). Can mediate sodium uptake when a transmembrane p [...]
nhaR protein networkhttps://string-db.org/network/511145.b0020Transcriptional activator of nhaA; Plays a role in the positive regulation of NhaA. Belongs to the LysR transcriptional regulatory family.
insB1 protein networkhttps://string-db.org/network/511145.b0021IS1 transposase B; Absolutely required for transposition of IS1.
insA protein networkhttps://string-db.org/network/511145.b0022IS1 repressor TnpA; Absolutely required for transposition of IS1.
rpsT protein networkhttps://string-db.org/network/511145.b002330S ribosomal subunit protein S20; Binds directly to 16S ribosomal RNA.
yaaY protein networkhttps://string-db.org/network/511145.b0024Uncharacterized protein.
ribF protein networkhttps://string-db.org/network/511145.b0025Bifunctional riboflavin kinase/FAD synthetase; Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD; Belongs to the RibF family.
ileS protein networkhttps://string-db.org/network/511145.b0026isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such e [...]
lspA protein networkhttps://string-db.org/network/511145.b0027Prolipoprotein signal peptidase (signal peptidase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
fkpB protein networkhttps://string-db.org/network/511145.b0028FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); PPIases accelerate the folding of proteins. Substrate specificity investigated with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide' where Xaa is the [...]
ispH protein networkhttps://string-db.org/network/511145.b00294-hydroxy-3-methylbut-2-enyl diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (I [...]
rihC protein networkhttps://string-db.org/network/511145.b0030Ribonucleoside hydrolase 3; Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity with decreasing activity in the order uridine, xanthosine, inosine, adenosine, [...]
dapB protein networkhttps://string-db.org/network/511145.b0031Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. Can use both NADH and NADPH as a reductant, with NADH being twice as [...]
carA protein networkhttps://string-db.org/network/511145.b0032Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process.
carB protein networkhttps://string-db.org/network/511145.b0033Carbamoyl-phosphate synthase large subunit; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process; Belongs to the CarB family.
caiF protein networkhttps://string-db.org/network/511145.b0034Cai operon transcriptional activator; Potential transcriptional activator of carnitine metabolism.
caiE protein networkhttps://string-db.org/network/511145.b0035Stimulator of CaiD and CaiB enzyme activities; Overproduction of CaiE stimulates the activity of CaiB and CaiD; Belongs to the transferase hexapeptide repeat family.
caiD protein networkhttps://string-db.org/network/511145.b0036carnitinyl-CoA dehydratase; Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.
caiC protein networkhttps://string-db.org/network/511145.b0037Putative crotonobetaine/carnitine-CoA ligase; Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward croton [...]
caiB protein networkhttps://string-db.org/network/511145.b0038Crotonobetainyl CoA:carnitine CoA transferase; Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetain [...]
caiA protein networkhttps://string-db.org/network/511145.b0039Crotonobetaine reductase subunit II, FAD-binding; Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA. The electron donor could be the FixA/FixB complex.
caiT protein networkhttps://string-db.org/network/511145.b0040Putative transporter; Catalyzes the exchange of L-carnitine for gamma-butyrobetaine and related betaines.
fixA protein networkhttps://string-db.org/network/511145.b0041Anaerobic carnitine reduction putative electron transfer flavoprotein subunit; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF beta-subunit/FixA family [...]
fixB protein networkhttps://string-db.org/network/511145.b0042Protein FixB; Required for anaerobic carnitine reduction. May bring reductant to CaiA; Belongs to the ETF alpha-subunit/FixB family.
fixC protein networkhttps://string-db.org/network/511145.b0043Putative oxidoreductase; Could be part of an electron transfer system required for anaerobic carnitine reduction; Belongs to the ETF-QO/FixC family.
fixX protein networkhttps://string-db.org/network/511145.b0044Putative 4Fe-4S ferredoxin-type protein; Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster-containing protein; Belongs to the bact [...]
yaaU protein networkhttps://string-db.org/network/511145.b0045Putative MFS sugar transporter; Putative transport protein.
kefF protein networkhttps://string-db.org/network/511145.b0046Potassium-efflux system ancillary protein for KefC, glutathione-regulated; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activit [...]
kefC protein networkhttps://string-db.org/network/511145.b0047Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Can also export rubidium, lithium and s [...]
folA protein networkhttps://string-db.org/network/511145.b0048Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
apaH protein networkhttps://string-db.org/network/511145.b0049Diadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.
apaG protein networkhttps://string-db.org/network/511145.b0050Protein associated with Co2+ and Mg2+ efflux.
rsmA protein networkhttps://string-db.org/network/511145.b005116S rRNA m(6)A1518, m(6)A1519 dimethyltransferase, SAM-dependent; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRN [...]
pdxA protein networkhttps://string-db.org/network/511145.b00524-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spo [...]
surA protein networkhttps://string-db.org/network/511145.b0053Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins, such as OmpA, OmpF and LamB. Recognizes specific patterns of aroma [...]
lptD protein networkhttps://string-db.org/network/511145.b0054LPS assembly OM complex LptDE, beta-barrel component; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Contributes to n-hexane res [...]
djlA protein networkhttps://string-db.org/network/511145.b0055Membrane-anchored DnaK co-chaperone, DNA-binding protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in th [...]
rluA protein networkhttps://string-db.org/network/511145.b0058Dual-specificity RNA pseudouridine synthase RluA; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon st [...]
rapA protein networkhttps://string-db.org/network/511145.b0059RNA polymerase remodeling/recycling factor ATPase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as superco [...]
polB protein networkhttps://string-db.org/network/511145.b0060DNA polymerase II; Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
araD protein networkhttps://string-db.org/network/511145.b0061L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D- xylulose 5-phosphate (D-Xu5P) via a retroald [...]
araA protein networkhttps://string-db.org/network/511145.b0062L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose.
araB protein networkhttps://string-db.org/network/511145.b0063L-ribulokinase; Protein involved in carbohydrate catabolic process; Belongs to the ribulokinase family.
araC protein networkhttps://string-db.org/network/511145.b0064Ara regulon transcriptional activator; Transcription factor that regulates the expression of several genes involved in the transport and metabolism of L-arabinose. Functions both as a positive an [...]
yabI protein networkhttps://string-db.org/network/511145.b0065DedA family inner membrane protein.
thiQ protein networkhttps://string-db.org/network/511145.b0066Thiamine/thiamine pyrophosphate ABC transporter ATPase; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system (Probable); [...]
thiP protein networkhttps://string-db.org/network/511145.b0067Thiamine/thiamine pyrophosphate ABC transporter permease; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate acros [...]
thiB protein networkhttps://string-db.org/network/511145.b0068Thiamine/thiamine pyrophosphate/thiamine monophosphate ABC transporter periplasmic binding protein; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Binds thiamine, thiamin [...]
sgrR protein networkhttps://string-db.org/network/511145.b0069Transcriptional DNA-binding transcriptional activator of sgrS sRNA; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription un [...]
setA protein networkhttps://string-db.org/network/511145.b0070Broad specificity sugar efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and gluco [...]
leuD protein networkhttps://string-db.org/network/511145.b00713-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
leuC protein networkhttps://string-db.org/network/511145.b00723-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM is [...]
leuB protein networkhttps://string-db.org/network/511145.b00733-isopropylmalate dehydrogenase, NAD(+)-dependent; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decar [...]
leuA protein networkhttps://string-db.org/network/511145.b00742-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isoprop [...]
leuL protein networkhttps://string-db.org/network/511145.b0075Leu operon leader peptide; Involved in control of the biosynthesis of leucine.
leuO protein networkhttps://string-db.org/network/511145.b0076Global transcription factor; A global transcription factor. Activates transcription of the 9 following operons; yjjQ-bglJ, yjjP, acrEF, ybdO, yjcRQP, casABCDE12, rhsD-ybbC, fepE and gltF, in most [...]
ilvI protein networkhttps://string-db.org/network/511145.b0077Acetolactate synthase III, valine sensitive, large subunit.
ilvH protein networkhttps://string-db.org/network/511145.b0078Acetolactate synthase III, valine sensitive, small subunit.
cra protein networkhttps://string-db.org/network/511145.b0080Transcriptional repressor-activator for carbon metabolism; Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes [...]
mraZ protein networkhttps://string-db.org/network/511145.b0081RsmH methytransferase inhibitor; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding di [...]
rsmH protein networkhttps://string-db.org/network/511145.b008216S rRNA m(4)C1402 methyltransferase, SAM-dependent; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. In vitro, active on the assembled 30S subunit, but n [...]
ftsL protein networkhttps://string-db.org/network/511145.b0083Membrane bound cell division leucine zipper septum protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the d [...]
ftsI protein networkhttps://string-db.org/network/511145.b0084Transpeptidase involved in septal peptidoglycan synthesis; Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum. Required for localiz [...]
murE protein networkhttps://string-db.org/network/511145.b0085UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (U [...]
murF protein networkhttps://string-db.org/network/511145.b0086UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murei [...]
mraY protein networkhttps://string-db.org/network/511145.b0087phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.
murD protein networkhttps://string-db.org/network/511145.b0088UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
ftsW protein networkhttps://string-db.org/network/511145.b0089Putative lipid II flippase; Peptidoglycan polymerase that is essential for cell division (Probable). Functions probably in conjunction with the penicillin- binding protein 3 (ftsI). Required for [...]
murG protein networkhttps://string-db.org/network/511145.b0090N-acetylglucosaminyl transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-py [...]
murC protein networkhttps://string-db.org/network/511145.b0091UDP-N-acetylmuramate:L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
ddlB protein networkhttps://string-db.org/network/511145.b0092D-alanine:D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.
ftsQ protein networkhttps://string-db.org/network/511145.b0093Divisome assembly protein, membrane anchored protein involved in growth of wall at septum; Essential cell division protein. May link together the upstream cell division proteins, which are predom [...]
ftsA protein networkhttps://string-db.org/network/511145.b0094ATP-binding cell division FtsK recruitment protein; Essential cell division protein that assists in the assembly of the Z ring. May serve as the principal membrane anchor for the Z ring. Also req [...]
ftsZ protein networkhttps://string-db.org/network/511145.b0095GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assem [...]
lpxC protein networkhttps://string-db.org/network/511145.b0096UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A bi [...]
secM protein networkhttps://string-db.org/network/511145.b0097Regulator of secA translation; Regulates secA expression by translational coupling of the secM secA operon. Ribosomes translating the C-terminal region of secM can disrupt an RNA repressor helix [...]
secA protein networkhttps://string-db.org/network/511145.b0098Preprotein translocase subunit, ATPase; Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the tran [...]
mutT protein networkhttps://string-db.org/network/511145.b0099dGTP-preferring nucleoside triphosphate pyrophosphohydrolase; Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the [...]
yacG protein networkhttps://string-db.org/network/511145.b0101DNA gyrase inhibitor; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrup [...]
zapD protein networkhttps://string-db.org/network/511145.b0102FtsZ stabilizer; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
coaE protein networkhttps://string-db.org/network/511145.b0103dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
guaC protein networkhttps://string-db.org/network/511145.b0104GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and [...]
hofC protein networkhttps://string-db.org/network/511145.b0106Assembly protein in type IV pilin biogenesis, transmembrane protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake.
hofB protein networkhttps://string-db.org/network/511145.b0107T2SE secretion family protein; Putative integral membrane protein involved in biogenesis of fimbriae, protein transport, DNA uptake; Belongs to the GSP E family.
ppdD protein networkhttps://string-db.org/network/511145.b0108Putative prepilin peptidase-dependent pilin; Not yet known; Belongs to the N-Me-Phe pilin family.
nadC protein networkhttps://string-db.org/network/511145.b0109Quinolinate phosphoribosyltransferase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
ampD protein networkhttps://string-db.org/network/511145.b01101,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid an [...]
ampE protein networkhttps://string-db.org/network/511145.b0111Ampicillin resistance inner membrane protein; Putative signaling protein in beta-lactamase regulation. AmpE seems not to act as a direct sensor for beta-lactams.
aroP protein networkhttps://string-db.org/network/511145.b0112Aromatic amino acid transporter; Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan).
pdhR protein networkhttps://string-db.org/network/511145.b0113Pyruvate dehydrogenase complex repressor; Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd.
aceE protein networkhttps://string-db.org/network/511145.b0114Pyruvate dehydrogenase, decarboxylase component E1, thiamine triphosphate-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acet [...]
aceF protein networkhttps://string-db.org/network/511145.b0115Pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple cop [...]
lpd protein networkhttps://string-db.org/network/511145.b0116Dihydrolipoyl dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes.
yacH protein networkhttps://string-db.org/network/511145.b0117DUF3300 family protein; Putative membrane protein.
acnB protein networkhttps://string-db.org/network/511145.b0118Aconitate hydratase 2; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and the 2- methylcitrate cycle I (propionate degrada [...]
yacL protein networkhttps://string-db.org/network/511145.b0119UPF0231 family protein.
speD protein networkhttps://string-db.org/network/511145.b0120S-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamin [...]
speE protein networkhttps://string-db.org/network/511145.b0121Spermidine synthase (putrescine aminopropyltransferase); Involved in the biosynthesis of polyamines which play a significant role in the structural and functional organization in the chromoid of [...]
yacC protein networkhttps://string-db.org/network/511145.b0122PulS_OutS family protein.
cueO protein networkhttps://string-db.org/network/511145.b0123Multicopper oxidase (laccase); Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase an [...]
gcd protein networkhttps://string-db.org/network/511145.b0124Glucose dehydrogenase; GDH is probably involved in energy conservation rather than in sugar metabolism; Belongs to the bacterial PQQ dehydrogenase family.
hpt protein networkhttps://string-db.org/network/511145.b0125Hypoxanthine phosphoribosyltransferase; Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine. Belongs to the purine/pyrimidine phosphoribosyltrans [...]
can protein networkhttps://string-db.org/network/511145.b0126Putative carbonic anhdrase; Belongs to the beta-class carbonic anhydrase family.
yadG protein networkhttps://string-db.org/network/511145.b0127Putative ABC transporter ATPase; Putative ATP-binding component of a transport system.
yadH protein networkhttps://string-db.org/network/511145.b0128Putative ABC transporter permease.
yadI protein networkhttps://string-db.org/network/511145.b0129Putative PTS Enzyme IIA; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming su [...]
yadE protein networkhttps://string-db.org/network/511145.b0130Putative polysaccharide deacetylase lipoprotein.
panD protein networkhttps://string-db.org/network/511145.b0131Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family.
yadD protein networkhttps://string-db.org/network/511145.b0132Transposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 2.9-fold, concomitantly reducing v [...]
panC protein networkhttps://string-db.org/network/511145.b0133Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
panB protein networkhttps://string-db.org/network/511145.b01343-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to [...]
yadC protein networkhttps://string-db.org/network/511145.b0135Putative fimbrial-like adhesin protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yadK protein networkhttps://string-db.org/network/511145.b0136Putative fimbrial-like adhesin protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yadL protein networkhttps://string-db.org/network/511145.b0137Putative fimbrial-like adhesin protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yadM protein networkhttps://string-db.org/network/511145.b0138Putative fimbrial-like adhesin protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
htrE protein networkhttps://string-db.org/network/511145.b0139Putative outer membrane usher protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the [...]
yadV protein networkhttps://string-db.org/network/511145.b0140Putative periplasmic pilin chaperone; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yadN protein networkhttps://string-db.org/network/511145.b0141Putative fimbrial-like adhesin protein; Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
folK protein networkhttps://string-db.org/network/511145.b01427,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase; Protein involved in folic acid biosynthetic process; Belongs to the HPPK family.
pcnB protein networkhttps://string-db.org/network/511145.b0143poly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencin [...]
gluQ protein networkhttps://string-db.org/network/511145.b0144glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto tRNA(Asp). Glutamate is transferred on the [...]
dksA protein networkhttps://string-db.org/network/511145.b0145Transcriptional regulator of rRNA transcription; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive [...]
sfsA protein networkhttps://string-db.org/network/511145.b0146Sugar fermentation stimulation protein A; Binds to DNA non-specifically. Could be a regulatory factor involved in maltose metabolism.
ligT protein networkhttps://string-db.org/network/511145.b01472'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester. In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl te [...]
hrpB protein networkhttps://string-db.org/network/511145.b0148Helicase, ATP-dependent; Protein involved in DNA-dependent DNA replication.
mrcB protein networkhttps://string-db.org/network/511145.b0149Fused glycosyl transferase and transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase [...]
fhuA protein networkhttps://string-db.org/network/511145.b0150Ferrichrome outer membrane transporter; Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane [...]
fhuC protein networkhttps://string-db.org/network/511145.b0151Iron(3+)-hydroxamate import ABC transporter ATPase; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system.
fhuD protein networkhttps://string-db.org/network/511145.b0152Iron(3+)-hydroxamate import ABC transporter periplasmic binding protein; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex [...]
fhuB protein networkhttps://string-db.org/network/511145.b0153Iron(3+)-hydroxamate import ABC transporter permease; Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across [...]
hemL protein networkhttps://string-db.org/network/511145.b0154Glutamate-1-semialdehyde aminotransferase (aminomutase).
clcA protein networkhttps://string-db.org/network/511145.b0155H(+)/Cl(-) exchange transporter; Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwar [...]
erpA protein networkhttps://string-db.org/network/511145.b0156Iron-sulfur cluster insertion protein; Probably involved in the insertion of Fe-S clusters into apoproteins in vivo including IspG and/or IspH. Essential for growth under aerobic conditions and f [...]
yadS protein networkhttps://string-db.org/network/511145.b0157UPF0126 family inner membrane protein.
btuF protein networkhttps://string-db.org/network/511145.b0158Vitamin B12 ABC transporter periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of [...]
mtn protein networkhttps://string-db.org/network/511145.b01595'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) [...]
dgt protein networkhttps://string-db.org/network/511145.b0160Deoxyguanosine triphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily.
degP protein networkhttps://string-db.org/network/511145.b0161Serine endoprotease (protease Do), membrane-associated; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently [...]
cdaR protein networkhttps://string-db.org/network/511145.b0162Carbohydrate diacid regulon transcriptional regulator; Seems to regulate the expression of the operons for the enzymes involved in D-galactarate, D-glucarate and D-glycerate utilization.
yaeH protein networkhttps://string-db.org/network/511145.b0163UPF0325 family protein; Putative structural protein; Belongs to the UPF0325 family.
yaeI protein networkhttps://string-db.org/network/511145.b0164Phosphodiesterase with model substrate bis-pNPP; Shows phosphodiesterase activity, hydrolyzing phosphodiester bond in the artificial chromogenic substrate bis-p-nitrophenyl phosphate (bis-pNPP); [...]
dapD protein networkhttps://string-db.org/network/511145.b01662,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Protein involved in lysine biosynthetic process via diaminopimelate; Belongs to the transferase hexapeptide repeat family.
glnD protein networkhttps://string-db.org/network/511145.b0167Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins GlnB and GlnK, in response to the nitrogen status of the cell that GlnD senses through the glutami [...]
map protein networkhttps://string-db.org/network/511145.b0168Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharg [...]
rpsB protein networkhttps://string-db.org/network/511145.b016930S ribosomal subunit protein S2; Required for ribosomal protein S1 to bind to the 30S subunit.
tsf protein networkhttps://string-db.org/network/511145.b0170Translation elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolys [...]
pyrH protein networkhttps://string-db.org/network/511145.b0171Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.
frr protein networkhttps://string-db.org/network/511145.b0172Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosome [...]
dxr protein networkhttps://string-db.org/network/511145.b01731-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP).
ispU protein networkhttps://string-db.org/network/511145.b0174Undecaprenyl pyrophosphate synthase; Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). UPP is the precursor of glycos [...]
cdsA protein networkhttps://string-db.org/network/511145.b0175CDP-diglyceride synthetase; Protein involved in phospholipid biosynthetic process.
rseP protein networkhttps://string-db.org/network/511145.b0176Inner membrane zinc RIP metalloprotease; A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of [...]
bamA protein networkhttps://string-db.org/network/511145.b0177BamABCDE complex OM biogenesis outer membrane pore-forming assembly factor; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel p [...]
skp protein networkhttps://string-db.org/network/511145.b0178Periplasmic chaperone; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the peri [...]
lpxD protein networkhttps://string-db.org/network/511145.b0179UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved [...]
fabZ protein networkhttps://string-db.org/network/511145.b0180(3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated an [...]
lpxA protein networkhttps://string-db.org/network/511145.b0181UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
lpxB protein networkhttps://string-db.org/network/511145.b0182tetraacyldisaccharide-1-P synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycoli [...]
rnhB protein networkhttps://string-db.org/network/511145.b0183Ribonuclease HII, degrades RNA of DNA-RNA hybrids; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
dnaE protein networkhttps://string-db.org/network/511145.b0184DNA polymerase III alpha subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exon [...]
accA protein networkhttps://string-db.org/network/511145.b0185acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its car [...]
ldcC protein networkhttps://string-db.org/network/511145.b0186Lysine decarboxylase 2, constitutive; Plays a role in lysine utilization by acting as a lysine decarboxylase.
yaeR protein networkhttps://string-db.org/network/511145.b0187Putative lyase; To B.subtilis YwkD.
tilS protein networkhttps://string-db.org/network/511145.b0188tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is [...]
rof protein networkhttps://string-db.org/network/511145.b0189Modulator of Rho-dependent transcription termination; Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination.
yaeQ protein networkhttps://string-db.org/network/511145.b0190PDDEXK superfamily protein.
arfB protein networkhttps://string-db.org/network/511145.b0191Alternative stalled-ribosome rescue factor B; Rescues stalled ribosomes. Can hydrolyze peptidyl-tRNA on ribosomes stalled by both non-stop mRNAs and mRNAs that contain rare codon clusters or rib [...]
nlpE protein networkhttps://string-db.org/network/511145.b0192Lipoprotein involved with copper homeostasis and adhesion; Involved in copper homeostasis, could be involved in both copper efflux and the delivery of copper to copper-dependent enzymes. Required [...]
yaeF protein networkhttps://string-db.org/network/511145.b0193Putative lipoprotein.
proS protein networkhttps://string-db.org/network/511145.b0194prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRN [...]
tsaA protein networkhttps://string-db.org/network/511145.b0195tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase, SAM-dependent; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-t [...]
rcsF protein networkhttps://string-db.org/network/511145.b0196Putative outer membrane protein; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the [...]
metQ protein networkhttps://string-db.org/network/511145.b0197DL-methionine transporter subunit; This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system. Belongs to the NlpA lipoprotein family.
metI protein networkhttps://string-db.org/network/511145.b0198DL-methionine transporter subunit; Part of the binding-protein-dependent transport system for D- methionine and the toxic methionine analog alpha-methyl-methionine. Probably responsible for the t [...]
metN protein networkhttps://string-db.org/network/511145.b0199DL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. It has also been shown to be [...]
gmhB protein networkhttps://string-db.org/network/511145.b0200D,D-heptose 1,7-bisphosphate phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phos [...]
dkgB protein networkhttps://string-db.org/network/511145.b02072,5-diketo-D-gluconate reductase B; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG); Belongs to the aldo/keto reductase family.
yafC protein networkhttps://string-db.org/network/511145.b0208Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yafD protein networkhttps://string-db.org/network/511145.b0209Endo/exonuclease/phosphatase family protein.
yafE protein networkhttps://string-db.org/network/511145.b0210Putative S-adenosyl-L-methionine-dependent methyltransferase; Putative biotin synthesis protein; Protein involved in biotin biosynthetic process; Belongs to the methyltransferase superfamily.
mltD protein networkhttps://string-db.org/network/511145.b0211Putative membrane-bound lytic murein transglycosylase D; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity); Belongs [...]
gloB protein networkhttps://string-db.org/network/511145.b0212Hydroxyacylglutathione hydrolase; Type II glyoxalase that catalyzes the hydrolysis of (R)-S- lactoylglutathione to (R)-lactate and glutathione. Is more efficient than the isozyme GloC, and plays [...]
yafS protein networkhttps://string-db.org/network/511145.b0213Putative S-adenosyl-L-methionine-dependent methyltransferase.
rnhA protein networkhttps://string-db.org/network/511145.b0214Ribonuclease HI, degrades RNA of DNA-RNA hybrids; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. RNase H participates in DNA replication; it helps to specify the origin of ge [...]
dnaQ protein networkhttps://string-db.org/network/511145.b0215DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing funct [...]
yafT protein networkhttps://string-db.org/network/511145.b0217Lipoprotein; Putative aminopeptidase.
yafV protein networkhttps://string-db.org/network/511145.b0219Omega-amidase YafV; Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha- ketoglutarate (alpha-KG) and ammonia, has weak activity on L-glutamine, almost no activity on deaminated glutathione (dGSH) [...]
ivy protein networkhttps://string-db.org/network/511145.b0220Inhibitor of c-type lysozyme, periplasmic; Strong inhibitor of lysozyme C.
fadE protein networkhttps://string-db.org/network/511145.b0221Acyl coenzyme A dehydrogenase; Catalyzes the dehydrogenation of acyl-coenzymes A (acyl-CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for [...]
gmhA protein networkhttps://string-db.org/network/511145.b0222D-sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.
yafJ protein networkhttps://string-db.org/network/511145.b0223Type 2 glutamine amidotransferase family protein; Putative amidotransferase.
yafK protein networkhttps://string-db.org/network/511145.b0224L,D-transpeptidase-related protein.
yafQ protein networkhttps://string-db.org/network/511145.b0225mRNA interferase toxin of toxin-antitoxin pair YafQ/DinJ; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific mRNA endoribonuclease that inhibits translation elongation [...]
dinJ protein networkhttps://string-db.org/network/511145.b0226Antitoxin of YafQ-DinJ toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin that counteracts the effect of cognate toxin YafQ. YafQ and DinJ to [...]
yafL protein networkhttps://string-db.org/network/511145.b0227Putative lipoprotein and C40 family peptidase; Putative lipoprotein.
rayT protein networkhttps://string-db.org/network/511145.b0228RAYT REP element-mobilizing transposase; Transposase that is always flanked by repeated extragenic palindrome (REP) sequences, which are clustered in structures called bacterial interspersed mosa [...]
dinB protein networkhttps://string-db.org/network/511145.b0231DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in translesion repair and untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo [...]
yafN protein networkhttps://string-db.org/network/511145.b0232Antitoxin of the YafO-YafN toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents YafO-mediated [...]
yafO protein networkhttps://string-db.org/network/511145.b0233mRNA interferase toxin of the YafO-YafN toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A translation-dependent mRNA interferase. Overexpression causes cessation [...]
yafP protein networkhttps://string-db.org/network/511145.b0234GNAT family putative N-acetyltransferase.
pepD protein networkhttps://string-db.org/network/511145.b0237Cytosol non-specific dipeptidase; Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-p [...]
gpt protein networkhttps://string-db.org/network/511145.b0238Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine.
frsA protein networkhttps://string-db.org/network/511145.b0239Fermentation-respiration switch protein; Displays esterase activity toward pNP-butyrate.
phoE protein networkhttps://string-db.org/network/511145.b0241Outer membrane porin PhoE; Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes; Belongs to the Gram-negative porin family.
proB protein networkhttps://string-db.org/network/511145.b0242Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
proA protein networkhttps://string-db.org/network/511145.b0243Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclizati [...]
ykfI protein networkhttps://string-db.org/network/511145.b0245Toxin YkfI; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a toxin inhibitor that blocks cell division and cell elongation via FtsZ and possibly also MreB (although no interact [...]
yafW protein networkhttps://string-db.org/network/511145.b0246CP4-6 prophage; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YkfI. It does not seem to bind to the cognate toxin but instea [...]
ykfG protein networkhttps://string-db.org/network/511145.b0247CP4-6 prophage; Putative DNA repair protein; Belongs to the UPF0758 family.
yafX protein networkhttps://string-db.org/network/511145.b0248CP4-6 prophage; uncharacterized protein; Belongs to the antirestriction protein family.
ykfF protein networkhttps://string-db.org/network/511145.b0249CP4-6 prophage; uncharacterized protein; Belongs to the UPF0401 family.
ykfB protein networkhttps://string-db.org/network/511145.b0250CP4-6 prophage; uncharacterized protein; To E.coli YfjT.
yafY protein networkhttps://string-db.org/network/511145.b0251Lipoprotein, inner membrane; When overproduced strongly induces degP through the activation of the two-component envelope stress response system CpxA/CpxR ; To E.coli YfjS.
yafZ protein networkhttps://string-db.org/network/511145.b0252UPF0380 protein YafZ; CP4-6 prophage; putative DNA-binding transcriptional regulator;Phage or Prophage Related; Belongs to the UPF0380 family.
ykfA protein networkhttps://string-db.org/network/511145.b0253CP4-6 prophage; Putative GTP-binding protein; To E.coli YfjP and YeeP.
perR protein networkhttps://string-db.org/network/511145.b0254CP4-6 prophage; Apparent regulatory gene involved in peroxide resistance in stationary phase; Belongs to the LysR transcriptional regulatory family.
insI1 protein networkhttps://string-db.org/network/511145.b0256Transposase InsI for insertion sequence element IS30A; Required for the transposition of the insertion element.
insH1 protein networkhttps://string-db.org/network/511145.b0259Transposase InsH for insertion sequence element IS5R; Involved in the transposition of the insertion sequence IS5.
mmuP protein networkhttps://string-db.org/network/511145.b0260CP4-6 prophage; Transporter for the intake of S-methylmethionine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
mmuM protein networkhttps://string-db.org/network/511145.b0261CP4-6 prophage; Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine.
afuC protein networkhttps://string-db.org/network/511145.b0262CP4-6 prophage; Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.
insB1-2 protein networkhttps://string-db.org/network/511145.b0264Insertion element IS1 2 protein InsB; Absolutely required for transposition of IS1.
insA-2 protein networkhttps://string-db.org/network/511145.b0265IS1 repressor TnpA; Absolutely required for transposition of IS1.
yagA protein networkhttps://string-db.org/network/511145.b0267Uncharacterized protein YagA; Pseudogene, CP4-6 prophage;Phage or Prophage Related.
yagE protein networkhttps://string-db.org/network/511145.b02682-keto-3-deoxy gluconate (KDG) aldolase; Catalyzes the formation of 2-keto-3-deoxy-gluconate (KDG) from pyruvate and glyceraldehyde. May also function as a 2-dehydro-3-deoxy-D-pentonate aldolase. [...]
yagF protein networkhttps://string-db.org/network/511145.b0269CP4-6 prophage; Catalyzes the dehydration of D-xylonic acid to form 2- dehydro-3-deoxy-D-pentonate; Belongs to the IlvD/Edd family.
yagG protein networkhttps://string-db.org/network/511145.b0270CP4-6 prophage; Putative permease.
yagH protein networkhttps://string-db.org/network/511145.b0271CP4-6 prophage; Putative beta-xylosidase.
yagI protein networkhttps://string-db.org/network/511145.b0272CP4-6 prophage; Involved in regulation of xylonate catabolism. Represses the expression of both yagA and yagEF operons. Binds mainly at a single site within the spacer of the bidirectional transc [...]
argF protein networkhttps://string-db.org/network/511145.b0273Ornithine carbamoyltransferase 2, chain F; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline [...]
insB1-3 protein networkhttps://string-db.org/network/511145.b0274Pseudogene.
insA-3 protein networkhttps://string-db.org/network/511145.b0275IS1 repressor TnpA.
yagK protein networkhttps://string-db.org/network/511145.b0277CP4-6 prophage; uncharacterized protein;Phage or Prophage Related; To E.coli YfjJ.
yagL protein networkhttps://string-db.org/network/511145.b0278CP4-6 prophage; DNA-binding protein.
yagM protein networkhttps://string-db.org/network/511145.b0279CP4-6 prophage; uncharacterized protein.
yagN protein networkhttps://string-db.org/network/511145.b0280CP4-6 prophage; uncharacterized protein.
intF protein networkhttps://string-db.org/network/511145.b0281CP4-6 prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision [...]
paoD protein networkhttps://string-db.org/network/511145.b0283Molybdenum cofactor insertion chaperone PaoD; Chaperone required for the production of an active PaoABC aldehyde oxidoreductase. Stabilizes the PaoC subunit and is required for the insertion of t [...]
paoC protein networkhttps://string-db.org/network/511145.b0284PaoABC aldehyde oxidoreductase, Moco-containing subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxificat [...]
paoB protein networkhttps://string-db.org/network/511145.b0285PaoABC aldehyde oxidoreductase, FAD-containing subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxificati [...]
paoA protein networkhttps://string-db.org/network/511145.b0286PaoABC aldehyde oxidoreductase, 2Fe-2S subunit; Oxidizes aldehydes to the corresponding carboxylic acids with a preference for aromatic aldehydes. It might play a role in the detoxification of al [...]
yagU protein networkhttps://string-db.org/network/511145.b0287DUF1440 family inner membrane acid resistance protein.
ykgJ protein networkhttps://string-db.org/network/511145.b0288UPF0153 cysteine cluster protein; Putative ferredoxin; Protein involved in electron carrier activity; To A.calcoaceticus putative ferredoxin.
ecpE protein networkhttps://string-db.org/network/511145.b0289ECP production pilus chaperone; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-sta [...]
ecpD protein networkhttps://string-db.org/network/511145.b0290Polymerized tip adhesin of ECP fibers; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in ea [...]
ecpC protein networkhttps://string-db.org/network/511145.b0291ECP production outer membrane protein; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in ea [...]
ecpB protein networkhttps://string-db.org/network/511145.b0292ECP production pilus chaperone; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-sta [...]
ecpA protein networkhttps://string-db.org/network/511145.b0293ECP pilin; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm developmen [...]
ecpR protein networkhttps://string-db.org/network/511145.b0294Putative transcriptional regulator for the ecp operon; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a [...]
ykgL protein networkhttps://string-db.org/network/511145.b0295Uncharacterized protein.
ykgM protein networkhttps://string-db.org/network/511145.b029650S ribosomal protein L31 type B; alternative zinc-limitation L31 protein.
insE1 protein networkhttps://string-db.org/network/511145.b0298Transposase InsE for insertion sequence IS3A; Involved in the transposition of the insertion sequence IS3.
insF1 protein networkhttps://string-db.org/network/511145.b0299IS3 transposase B; Involved in the transposition of the insertion sequence IS3.
rclC protein networkhttps://string-db.org/network/511145.b0301Inner membrane protein RclC; Probably involved in reactive chlorine species (RCS) stress resistance.
rclB protein networkhttps://string-db.org/network/511145.b0303Reactive chlorine species (RCS) stress resistance periplasmic protein; Probably involved in reactive chlorine species (RCS) stress resistance; Belongs to the BhsA/McbA family.
rclA protein networkhttps://string-db.org/network/511145.b0304Reactive chlorine stress species (RCS) resistance protein; Probably involved in reactive chlorine species (RCS) stress resistance.
rclR protein networkhttps://string-db.org/network/511145.b0305Reactive chlorine species (RCS)-specific activator of the rcl genes; Involved in reactive chlorine species (RCS) stress resistance. Upregulates, in response to hypochlorous acid (HOCl), the expre [...]
ykgE protein networkhttps://string-db.org/network/511145.b0306Cysteine-rich LutA family protein; Putative dehydrogenase subunit.
ykgF protein networkhttps://string-db.org/network/511145.b0307Ferridoxin-like LutB family protein; putative electron transport chain YkgEFG component.
ykgG protein networkhttps://string-db.org/network/511145.b0308LutC family protein; Putative transporter.
ykgH protein networkhttps://string-db.org/network/511145.b0310Putative inner membrane protein.
betA protein networkhttps://string-db.org/network/511145.b0311Choline dehydrogenase, a flavoprotein; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine b [...]
betB protein networkhttps://string-db.org/network/511145.b0312Betaine aldehyde dehydrogenase, NAD-dependent; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid [...]
betI protein networkhttps://string-db.org/network/511145.b0313Choline-inducible betIBA-betT divergent operon transcriptional repressor; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline t [...]
betT protein networkhttps://string-db.org/network/511145.b0314Choline transporter of high affinity; High-affinity uptake of choline driven by a proton-motive force; Belongs to the BCCT transporter (TC 2.A.15) family.
yahA protein networkhttps://string-db.org/network/511145.b0315c-di-GMP-specific phosphodiesterase; Acts both as an enzyme and as a c-di-GMP sensor to couple transcriptional activity to the c-di-GMP status of the cell. Phosphodiesterase (PDE) that catalyzes [...]
yahB protein networkhttps://string-db.org/network/511145.b0316Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription.
yahC protein networkhttps://string-db.org/network/511145.b0317Putative inner membrane protein.
yahD protein networkhttps://string-db.org/network/511145.b0318Ankyrin repeat protein; Putative transcription factor.
yahE protein networkhttps://string-db.org/network/511145.b0319DUF2877 family protein.
yahF protein networkhttps://string-db.org/network/511145.b0320Putative NAD(P)-binding succinyl-CoA synthase; Putative oxidoreductase subunit; To E.coli FdrA and some, to bacterial SucD.
yahG protein networkhttps://string-db.org/network/511145.b0321DUF1116 family protein.
yahI protein networkhttps://string-db.org/network/511145.b0323Carbamate kinase-like protein; Putative kinase; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process; Belongs to the carbamate kinase family.
yahJ protein networkhttps://string-db.org/network/511145.b0324Putative metallo-dependent hydrolase domain deaminase; Putative deaminase; Protein involved in amine catabolic process.
yahK protein networkhttps://string-db.org/network/511145.b0325Broad specificity NADPH-dependent aldehyde reductase, Zn-containing; Catalyzes the reduction of a wide range of aldehydes into their corresponding alcohols. Has a strong preference for NADPH over [...]
yahL protein networkhttps://string-db.org/network/511145.b0326Uncharacterized protein.
yahM protein networkhttps://string-db.org/network/511145.b0327Uncharacterized protein.
yahN protein networkhttps://string-db.org/network/511145.b0328Amino acid exporter for proline, lysine, glutamate, homoserine; Putative cytochrome subunit of dehydrogenase.
yahO protein networkhttps://string-db.org/network/511145.b0329Periplasmic protein, function unknown, YhcN family.
prpR protein networkhttps://string-db.org/network/511145.b0330Propionate catabolism operon regulatory protein; Involved in the transcriptional regulation of the propionate catabolism operon.
prpB protein networkhttps://string-db.org/network/511145.b03312-methylisocitrate lyase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C [...]
prpC protein networkhttps://string-db.org/network/511145.b03332-methylcitrate synthase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionate d [...]
prpD protein networkhttps://string-db.org/network/511145.b03342-methylcitrate dehydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle I (propionat [...]
prpE protein networkhttps://string-db.org/network/511145.b0335propionate--CoA ligase; Catalyzes the synthesis of propionyl-CoA from propionate and CoA. Also converts acetate to acetyl-CoA but with a lower specific activity (By similarity).
codB protein networkhttps://string-db.org/network/511145.b0336Cytosine transporter; Required for cytosine transport into the cell; Belongs to the purine-cytosine permease (2.A.39) family.
codA protein networkhttps://string-db.org/network/511145.b0337Cytosine/isoguanine deaminase; Catalyzes the hydrolytic deamination of cytosine to uracil. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine [...]
cynR protein networkhttps://string-db.org/network/511145.b0338Transcriptional activator of cyn operon; Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR-cynTSX intergenic region.
cynT protein networkhttps://string-db.org/network/511145.b0339Carbonic anhydrase; Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (CynS) diffuses out of the cell faster than it w [...]
cynS protein networkhttps://string-db.org/network/511145.b0340Cyanate aminohydrolase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
cynX protein networkhttps://string-db.org/network/511145.b0341Putative cyanate transporter; This protein is part of an active transport system that transports exogenous cyanate into E.coli cells; Belongs to the major facilitator superfamily. Cyanate porter [...]
lacA protein networkhttps://string-db.org/network/511145.b0342Thiogalactoside acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to the 6-O-methyl position of a range of galactosides, glucosides, and lactosides. May assist cellular d [...]
lacY protein networkhttps://string-db.org/network/511145.b0343Lactose permease; Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Can transport lactose, melibiose, lactulose or the analog [...]
lacZ protein networkhttps://string-db.org/network/511145.b0344beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family.
lacI protein networkhttps://string-db.org/network/511145.b0345Lactose-inducible lac operon transcriptional repressor; Repressor of the lactose operon. Binds allolactose as an inducer.
mhpR protein networkhttps://string-db.org/network/511145.b0346Mhp operon transcriptional activator; Activator of the mhpABCDFE operon coding for components of the 3-hydroxyphenylpropionate degradation pathway.
mhpA protein networkhttps://string-db.org/network/511145.b03473-(3-hydroxyphenyl)propionate hydroxylase; Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic [...]
mhpB protein networkhttps://string-db.org/network/511145.b03482,3-dihydroxyphenylpropionate 1,2-dioxygenase; Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ke [...]
mhpC protein networkhttps://string-db.org/network/511145.b03492-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product [...]
mhpD protein networkhttps://string-db.org/network/511145.b03502-keto-4-pentenoate hydratase; Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. Belongs to the hydratase/decarboxylase [...]
mhpF protein networkhttps://string-db.org/network/511145.b0351acetaldehyde-CoA dehydrogenase II, NAD-binding; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degra [...]
mhpE protein networkhttps://string-db.org/network/511145.b03524-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase, class I; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cle [...]
mhpT protein networkhttps://string-db.org/network/511145.b03533-hydroxyphenylpropionic transporter; Uptake of 3-(3-hydroxyphenyl)propionate (3HPP) across the cytoplasmic membrane. Transport is driven by the proton motive force. Does not transport benzoate, [...]
yaiL protein networkhttps://string-db.org/network/511145.b0354DUF2058 family protein.
frmB protein networkhttps://string-db.org/network/511145.b0355S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against two [...]
frmA protein networkhttps://string-db.org/network/511145.b0356Alcohol dehydrogenase class III; Has high formaldehyde dehydrogenase activity in the presence of glutathione and catalyzes the oxidation of normal alcohols in a reaction that is not GSH-dependent [...]
frmR protein networkhttps://string-db.org/network/511145.b0357Regulator protein that represses frmRAB operon; Repressor of the frmRAB operon.
yaiO protein networkhttps://string-db.org/network/511145.b0358Outer membrane protein.
insC1 protein networkhttps://string-db.org/network/511145.b0360Transposase InsC for insertion element IS2-10; Involved in the transposition of the insertion sequence IS2.
insD1 protein networkhttps://string-db.org/network/511145.b0361IS2 transposase TnpB; Involved in the transposition of the insertion sequence IS2.
yaiP protein networkhttps://string-db.org/network/511145.b0363Putative family 2 glycosyltransferase; Polysaccharide metabolism; Protein involved in polysaccharide biosynthetic process; Belongs to the glycosyltransferase 2 family.
yaiS protein networkhttps://string-db.org/network/511145.b0364Putative PIG-L family deacetylase; Belongs to the PIGL family.
tauA protein networkhttps://string-db.org/network/511145.b0365Taurine ABC transporter periplasmic binding protein; Part of a binding-protein-dependent transport system for taurine.
tauB protein networkhttps://string-db.org/network/511145.b0366Taurine ABC transporter ATPase; Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system.
tauC protein networkhttps://string-db.org/network/511145.b0367Taurine ABC transporter permease; Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane; Belongs to the [...]
tauD protein networkhttps://string-db.org/network/511145.b0368Taurine dioxygenase, 2-oxoglutarate-dependent; Catalyzes the alpha-ketoglutarate-dependent hydroxylation of taurine yielding sulfite and aminoacetaldehyde after decomposition of an unstable inter [...]
hemB protein networkhttps://string-db.org/network/511145.b03695-aminolevulinate dehydratase (porphobilinogen synthase); Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct si [...]
insF1-2 protein networkhttps://string-db.org/network/511145.b0372Pseudogene, autotransporter family;putative structure; Not classified; interrupted by IS3; putative flagellin structural protein.
insE1-2 protein networkhttps://string-db.org/network/511145.b0373IS3 transposase A.
yaiV protein networkhttps://string-db.org/network/511145.b0375Putative transcriptional regulator; Involved in oxidative stress resistance; Belongs to the IprA family.
ampH protein networkhttps://string-db.org/network/511145.b0376D-alanyl-D-alanine- carboxypeptidase/endopeptidase; Hydrolyzes the cross-linked dimers tetrapentapeptide (D45) and tetratetrapeptide (D44). Removes the terminal D-alanine from muropeptides and di [...]
sbmA protein networkhttps://string-db.org/network/511145.b0377Peptide antibiotic transporter; Uptake of antimicrobial peptides. Required for the transport of microcin B17 (MccB17), microcin 25 (Mcc25) and proline-rich antimicrobial peptides into the cell.
yaiW protein networkhttps://string-db.org/network/511145.b0378Microcin Bac7 uptake protein; outer membrane surface-exposed lipoprotein.
yaiY protein networkhttps://string-db.org/network/511145.b0379DUF2755 family inner membrane protein.
yaiZ protein networkhttps://string-db.org/network/511145.b0380DUF2754 family putative inner membrane protein.
ddlA protein networkhttps://string-db.org/network/511145.b0381D-alanine-D-alanine ligase A; Cell wall formation.
iraP protein networkhttps://string-db.org/network/511145.b0382anti-RssB factor, RpoS stabilzer during Pi starvation; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during ph [...]
phoA protein networkhttps://string-db.org/network/511145.b0383Alkaline phosphatase; start codon corrected; Protein involved in phosphorus metabolic process; Belongs to the alkaline phosphatase family.
psiF protein networkhttps://string-db.org/network/511145.b0384PsiF family protein; Induced by phosphate starvation; Protein involved in phosphorus metabolic process and response to starvation.
yaiC protein networkhttps://string-db.org/network/511145.b0385Diguanylate cyclase, cellulose regualtor; A probable diguanylate cyclase. The last member of a cascade of expressed proteins, its expression requires DgcM. DgcC production induces biosynthesis of [...]
proC protein networkhttps://string-db.org/network/511145.b0386Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. Does not catalyze the reverse reaction.
yaiI protein networkhttps://string-db.org/network/511145.b0387UPF0178 family protein.
aroL protein networkhttps://string-db.org/network/511145.b0388Shikimate kinase II; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Belongs to the shikimate kinase family. AroL subfamily.
yaiA protein networkhttps://string-db.org/network/511145.b0389OxyR-regulated conserved protein.
aroM protein networkhttps://string-db.org/network/511145.b0390AroM family protein; This protein of unknown function is encoded by a gene that cotranscribes with the aroL gene, which codes for shikimate kinase II.
yaiE protein networkhttps://string-db.org/network/511145.b0391UPF0345 family protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidin [...]
rdgC protein networkhttps://string-db.org/network/511145.b0393Recombination-associated protein RdgC; May be involved in recombination; Belongs to the RdgC family.
mak protein networkhttps://string-db.org/network/511145.b0394Manno(fructo)kinase; Catalyzes the phosphorylation of fructose to fructose-6-P. Has also low level glucokinase activity in vitro. Is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, in [...]
araJ protein networkhttps://string-db.org/network/511145.b0396L-arabinose-inducible putative transporter, MFS family; May be involved in either the transport or processing of arabinose polymers; Belongs to the major facilitator superfamily.
sbcC protein networkhttps://string-db.org/network/511145.b0397Exonuclease, dsDNA, ATP-dependent; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex act [...]
sbcD protein networkhttps://string-db.org/network/511145.b0398Exonuclease, dsDNA, ATP-dependent; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex act [...]
phoB protein networkhttps://string-db.org/network/511145.b0399Response regulator in two-component regulatory system with PhoR; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and P [...]
phoR protein networkhttps://string-db.org/network/511145.b0400Sensory histidine kinase in two-component regulatory system with PhoB; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may functio [...]
brnQ protein networkhttps://string-db.org/network/511145.b0401Branched-chain amino acid transport system 2 carrier protein; Component of the LIV-II transport system for branched-chain amino acids. This LIV-II transport system may be H(+)-coupled.
proY protein networkhttps://string-db.org/network/511145.b0402Proline-specific permease; Permease that is involved in the transport across the cytoplasmic membrane of proline; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid tr [...]
malZ protein networkhttps://string-db.org/network/511145.b0403Maltodextrin glucosidase; May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length o [...]
acpH protein networkhttps://string-db.org/network/511145.b0404Acyl carrier protein (ACP) phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family.
queA protein networkhttps://string-db.org/network/511145.b0405S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ [...]
tgt protein networkhttps://string-db.org/network/511145.b0406tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in t [...]
yajC protein networkhttps://string-db.org/network/511145.b0407SecYEG protein translocase auxillary subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins [...]
secD protein networkhttps://string-db.org/network/511145.b0408SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to com [...]
secF protein networkhttps://string-db.org/network/511145.b0409SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to com [...]
yajD protein networkhttps://string-db.org/network/511145.b0410HNH nuclease family protein; Belongs to the HNH nuclease family.
tsx protein networkhttps://string-db.org/network/511145.b0411Nucleoside channel, receptor of phage T6 and colicin K; Functions as substrate-specific channel for nucleosides and deoxynucleosides. Has a greater affinity for deoxynucleosides than for nucleosi [...]
yajI protein networkhttps://string-db.org/network/511145.b0412Putative lipoprotein.
nrdR protein networkhttps://string-db.org/network/511145.b0413Nrd regulon repressor; Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By bin [...]
ribD protein networkhttps://string-db.org/network/511145.b0414Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphat [...]
ribE protein networkhttps://string-db.org/network/511145.b0415Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is t [...]
nusB protein networkhttps://string-db.org/network/511145.b0416Transcription antitermination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence [...]
thiL protein networkhttps://string-db.org/network/511145.b0417Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1. Cannot use thiamin [...]
pgpA protein networkhttps://string-db.org/network/511145.b0418Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
yajO protein networkhttps://string-db.org/network/511145.b04192-carboxybenzaldehyde reductase; Catalyzes the conversion of ribulose 5-phosphate (Ru5P) to 1- deoxy-D-xylulose 5-phosphate (DXP), providing a direct route from pentoses to terpenes. May play a r [...]
dxs protein networkhttps://string-db.org/network/511145.b04201-deoxyxylulose-5-phosphate synthase, thiamine triphosphate-binding, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate [...]
ispA protein networkhttps://string-db.org/network/511145.b0421Geranyltranstransferase; Belongs to the FPP/GGPP synthase family.
xseB protein networkhttps://string-db.org/network/511145.b0422Exonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. [...]
thiI protein networkhttps://string-db.org/network/511145.b0423tRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes t [...]
yajL protein networkhttps://string-db.org/network/511145.b0424Oxidative-stress-resistance chaperone; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive [...]
panE protein networkhttps://string-db.org/network/511145.b04252-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
yajQ protein networkhttps://string-db.org/network/511145.b0426Phage Phi6 host factor, ATP/GTP binding protein; Binds nucleotides, may bind tRNA.
yajR protein networkhttps://string-db.org/network/511145.b0427Putative transport protein; Protein involved in response to drug.
cyoE protein networkhttps://string-db.org/network/511145.b0428Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
cyoD protein networkhttps://string-db.org/network/511145.b0429Cytochrome o ubiquinol oxidase subunit IV; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high a [...]
cyoC protein networkhttps://string-db.org/network/511145.b0430Cytochrome o ubiquinol oxidase subunit III; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high [...]
cyoB protein networkhttps://string-db.org/network/511145.b0431Cytochrome o ubiquinol oxidase subunit I; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high ae [...]
cyoA protein networkhttps://string-db.org/network/511145.b0432Cytochrome o ubiquinol oxidase subunit II; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high a [...]
ampG protein networkhttps://string-db.org/network/511145.b0433Muropeptide transporter; Permease involved in cell wall peptidoglycan recycling. Transports, from the periplasm into the cytoplasm, the disaccharide N-acetylglucosaminyl-beta-1,4-anhydro- N-acety [...]
yajG protein networkhttps://string-db.org/network/511145.b0434Putative polymerase/proteinase.
bolA protein networkhttps://string-db.org/network/511145.b0435Stationary-phase morphogene, transcriptional repressor for mreB; Transcriptional regulator that plays an important role in general stress response. Has many effects on cell morphology, cell growt [...]
tig protein networkhttps://string-db.org/network/511145.b0436Peptidyl-prolyl cis/trans isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized secretory and non-secretory proteins in an open conforma [...]
clpP protein networkhttps://string-db.org/network/511145.b0437Proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Pl [...]
clpX protein networkhttps://string-db.org/network/511145.b0438ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease; ATP-dependent specificity component of the Clp protease. Uses cycles of ATP binding and hydrolysis to unfold proteins an [...]
lon protein networkhttps://string-db.org/network/511145.b0439DNA-binding ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins, i [...]
hupB protein networkhttps://string-db.org/network/511145.b0440HU, DNA-binding transcriptional regulator, beta subunit; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme envi [...]
ppiD protein networkhttps://string-db.org/network/511145.b0441Periplasmic folding chaperone, has an inactive PPIase domain; PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins. Its preference at the P1 [...]
ybaV protein networkhttps://string-db.org/network/511145.b0442Putative competence-suppressing periplasmic helix-hairpin-helix DNA-binding protein.
fadM protein networkhttps://string-db.org/network/511145.b0443Long-chain acyl-CoA thioesterase III; Long-chain acyl-CoA thioesterase with a preference for 3,5- tetradecadienoyl-CoA. Could be involved in beta-oxidation of fatty acids; Belongs to the 4-hydrox [...]
queC protein networkhttps://string-db.org/network/511145.b04447-cyano-7-deazaguanine (preQ0) synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
ybaE protein networkhttps://string-db.org/network/511145.b0445Putative ABC transporter periplasmic binding protein.
cof protein networkhttps://string-db.org/network/511145.b0446Thiamine pyrimidine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphat [...]
ybaO protein networkhttps://string-db.org/network/511145.b0447Putative DNA-binding transcriptional regulator; Plays a role in L-cysteine detoxification. Binds to the dlsT(yhaO)-yhaM operon promoter in the presence but not absence of L- cysteine; activates t [...]
mdlA protein networkhttps://string-db.org/network/511145.b0448Putative multidrug ABC transporter ATPase; Protein involved in response to drug; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family.
mdlB protein networkhttps://string-db.org/network/511145.b0449Putative multidrug ABC transporter ATPase; Belongs to the ABC transporter superfamily. Drug exporter-2 (TC 3.A.1.117) family.
glnK protein networkhttps://string-db.org/network/511145.b0450Nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of [...]
amtB protein networkhttps://string-db.org/network/511145.b0451Ammonium transporter; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
tesB protein networkhttps://string-db.org/network/511145.b0452acyl-CoA thioesterase 2; Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known; Belongs to the C/M/P thioester hydrolase family.
ybaY protein networkhttps://string-db.org/network/511145.b0453Outer membrane lipoprotein; Glycoprotein/polysaccharide metabolism; Protein involved in lipoprotein biosynthetic process and glycoprotein biosynthetic process.
ybaZ protein networkhttps://string-db.org/network/511145.b0454Excision repair protein, alkyltransferase-like protein ATL; Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts, and to double- strand [...]
ybaA protein networkhttps://string-db.org/network/511145.b0456DUF1428 family protein.
ylaB protein networkhttps://string-db.org/network/511145.b0457Putative membrane-anchored cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
ylaC protein networkhttps://string-db.org/network/511145.b0458DUF1449 family inner membrane protein.
maa protein networkhttps://string-db.org/network/511145.b0459Maltose O-acetyltransferase; Catalyzes the CoA-dependent transfer of an acetyl group to maltose and other sugars. Acetylates glucose exclusively at the C6 position and maltose at the C6 position [...]
hha protein networkhttps://string-db.org/network/511145.b0460Modulator of gene expression, with H-NS; Down-regulates hemolysin (hly) expression in complex with H- NS. Stimulates transposition events in vivo. Modifies the set of genes regulated by H-NS; Hha [...]
tomB protein networkhttps://string-db.org/network/511145.b0461Hha toxicity attenuator; Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA.
acrB protein networkhttps://string-db.org/network/511145.b0462Multidrug efflux system protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates.
acrA protein networkhttps://string-db.org/network/511145.b0463Multidrug efflux system; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an a [...]
acrR protein networkhttps://string-db.org/network/511145.b0464Transcriptional repressor; Potential regulator protein for the acrAB genes.
mscK protein networkhttps://string-db.org/network/511145.b0465Mechanosensitive channel protein, intermediate conductance, K+ regulated; Mechanosensitive channel that opens in response to membrane tension and specific ionic conditions. Requires high concentr [...]
ybaM protein networkhttps://string-db.org/network/511145.b0466DUF2496 family protein.
priC protein networkhttps://string-db.org/network/511145.b0467Primosomal replication protein N'; PriA recognizes a specific hairpin sequence on bacteriophage phi X174 ssDNA. This structure is then recognized and bound by proteins PriB and PriC. Formation of [...]
ybaN protein networkhttps://string-db.org/network/511145.b0468DUF454 family inner membrane protein.
apt protein networkhttps://string-db.org/network/511145.b0469Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
dnaX protein networkhttps://string-db.org/network/511145.b0470DNA polymerase III/DNA elongation factor III, tau and gamma subunits; Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA r [...]
ybaB protein networkhttps://string-db.org/network/511145.b0471DNA-binding protein, putative nucleoid-associated protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
recR protein networkhttps://string-db.org/network/511145.b0472Gap repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
htpG protein networkhttps://string-db.org/network/511145.b0473Protein refolding molecular co-chaperone Hsp90, Hsp70-dependent; Molecular chaperone. Has ATPase activity.
adk protein networkhttps://string-db.org/network/511145.b0474Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolis [...]
hemH protein networkhttps://string-db.org/network/511145.b0475Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family.
aes protein networkhttps://string-db.org/network/511145.b0476Acetyl esterase; Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tribut [...]
gsk protein networkhttps://string-db.org/network/511145.b0477Inosine-guanosine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion.
ybaL protein networkhttps://string-db.org/network/511145.b0478Inner membrane putative NAD(P)-binding transporter; Putative transport protein.
fsr protein networkhttps://string-db.org/network/511145.b0479Putative fosmidomycin efflux system protein; Confers the resistance against fosmidomycin; Belongs to the major facilitator superfamily.
ushA protein networkhttps://string-db.org/network/511145.b0480Bifunctional UDP-sugar hydrolase/5'-nucleotidase; Degradation of external UDP-glucose to uridine monophosphate and glucose-1-phosphate, which can then be used by the cell.
ybaK protein networkhttps://string-db.org/network/511145.b0481Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. May compensate for the lack of Cys- [...]
ybaP protein networkhttps://string-db.org/network/511145.b0482TraB family protein; Putative ligase.
ybaQ protein networkhttps://string-db.org/network/511145.b0483Putative DNA-binding transcriptional regulator; Belongs to the VapA/VapI family.
copA protein networkhttps://string-db.org/network/511145.b0484Copper transporter; [Copper-exporting P-type ATPase]: Exports Cu(+) from the cytoplasm to the periplasm. Binds 2 Cu(+) ions per monomer, which are transferred to periplasmic copper chaperone CusF [...]
glsA protein networkhttps://string-db.org/network/511145.b0485Putative glutaminase; Protein involved in cellular amino acid catabolic process.
ybaT protein networkhttps://string-db.org/network/511145.b0486Putative amino acid transporter; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
cueR protein networkhttps://string-db.org/network/511145.b0487Copper-responsive regulon transcriptional regulator; Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increa [...]
ybbJ protein networkhttps://string-db.org/network/511145.b0488Inner membrane protein; stimulator of the QmcA suppressor of ftsH-htpX.
qmcA protein networkhttps://string-db.org/network/511145.b0489PHB domain membrane-anchored putative protease; Identified as a multi-copy suppressor of an FtsH/HtpX protease double disruption mutant. May play a role in the quality control of integral membran [...]
fetA protein networkhttps://string-db.org/network/511145.b0490Iron export ABC transporter ATPase; Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably re [...]
fetB protein networkhttps://string-db.org/network/511145.b0491Iron export ABC transporter permease; Part of the ABC transporter complex FetAB, which is probably involved in iron export and enhances resistance to H(2)O(2)-mediated oxidative stress. Probably [...]
ybbN protein networkhttps://string-db.org/network/511145.b0492DnaK co-chaperone, thioredoxin-like protein; Chaperedoxin that combines a chaperone activity with a redox- protective function. Involved in the protection against hypochlorous acid (HOCl), the ac [...]
ybbO protein networkhttps://string-db.org/network/511145.b0493Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
tesA protein networkhttps://string-db.org/network/511145.b0494acyl-CoA thioesterase 1 and protease I and lysophospholipase L1; TesA is a multifunctional esterase that can act as a thioesterase, lysophospholipase and protease. TesA functions as a thioesteras [...]
ybbA protein networkhttps://string-db.org/network/511145.b0495Putative ABC transporter ATPase; Putative ATP-binding component of a transport system; Belongs to the ABC transporter superfamily.
ybbP protein networkhttps://string-db.org/network/511145.b0496Putative ABC transporter permease; Putative oxidoreductase.
rhsD protein networkhttps://string-db.org/network/511145.b0497Rhs protein with DUF4329 family putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell.
ybbC protein networkhttps://string-db.org/network/511145.b0498Putative immunity protein.
mnmH protein networkhttps://string-db.org/network/511145.b0503tRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-t [...]
allS protein networkhttps://string-db.org/network/511145.b0504allD operon transcriptional activator; Positive regulator essential for the expression of allD operon. Binds to the allD promoter; Belongs to the LysR transcriptional regulatory family.
allA protein networkhttps://string-db.org/network/511145.b0505Ureidoglycolate lyase, releasing urea; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the anaerobic utilizatio [...]
allR protein networkhttps://string-db.org/network/511145.b0506Glyoxylate-inducible transcriptional repressor of all and gcl operons; Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS-allA intergeni [...]
gcl protein networkhttps://string-db.org/network/511145.b0507Glyoxylate carboligase; Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
hyi protein networkhttps://string-db.org/network/511145.b0508Hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). Does not catalyze the isomerization [...]
glxR protein networkhttps://string-db.org/network/511145.b0509Tartronate semialdehyde reductase, NADH-dependent; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the HIBADH-relate [...]
ybbW protein networkhttps://string-db.org/network/511145.b0511Putative allantoin transporter; Transport of allantoin.
allB protein networkhttps://string-db.org/network/511145.b0512Allantoinase; Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring; Belongs to the metallo-dependent hydrolases sup [...]
ybbY protein networkhttps://string-db.org/network/511145.b0513Putative uracil/xanthine transporter; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
glxK protein networkhttps://string-db.org/network/511145.b0514Glycerate kinase II; Protein involved in carbohydrate catabolic process, glycolate metabolic process and allantoin assimilation pathway; Belongs to the glycerate kinase type-1 family.
allE protein networkhttps://string-db.org/network/511145.b0515S-ureidoglycine aminohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes the second stereospecific hydrolysis reaction (deamination) of the alla [...]
allC protein networkhttps://string-db.org/network/511145.b0516Allantoate amidohydrolase; Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S- ureidogly [...]
allD protein networkhttps://string-db.org/network/511145.b0517Ureidoglycolate dehydrogenase; AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole so [...]
fdrA protein networkhttps://string-db.org/network/511145.b0518Putative NAD(P)-binding acyl-CoA synthetase; Not known; multicopy suppressor of dominant negative ftsH mutations; To E.coli YahF and some, to bacterial SucD.
ylbF protein networkhttps://string-db.org/network/511145.b0520Putative anaerobic allantoin catabolic oxamate carbamoyltransferase; Putative carboxylase.
ybcF protein networkhttps://string-db.org/network/511145.b0521Putative carbamate kinase; Protein involved in arginine biosynthetic process and pyrimidine nucleotide biosynthetic process.
purK protein networkhttps://string-db.org/network/511145.b0522N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR [...]
purE protein networkhttps://string-db.org/network/511145.b0523N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the A [...]
lpxH protein networkhttps://string-db.org/network/511145.b0524UDP-2,3-diacylglucosamine pyrophosphohydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the atta [...]
ppiB protein networkhttps://string-db.org/network/511145.b0525Peptidyl-prolyl cis-trans isomerase B (rotamase B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
cysS protein networkhttps://string-db.org/network/511145.b0526Cysteine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family.
ybcI protein networkhttps://string-db.org/network/511145.b0527DUF457 family inner membrane protein.
ybcJ protein networkhttps://string-db.org/network/511145.b0528Ribosome-associated protein; Its structure and the presence of conserved basic residues indicates that it probably binds RNA.
folD protein networkhttps://string-db.org/network/511145.b0529Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10 [...]
sfmA protein networkhttps://string-db.org/network/511145.b0530FimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladd [...]
sfmC protein networkhttps://string-db.org/network/511145.b0531Putative periplasmic pilus chaperone; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 [...]
sfmD protein networkhttps://string-db.org/network/511145.b0532Putative outer membrane export usher protein; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukary [...]
sfmH protein networkhttps://string-db.org/network/511145.b0533FimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladd [...]
sfmF protein networkhttps://string-db.org/network/511145.b0534FimA homolog, function unknown; Part of the sfmACDHF fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladd [...]
sfmZ protein networkhttps://string-db.org/network/511145.b0535Response regulator family protein; Fimbrial Z protein; probable signal transducer; Protein involved in transcription activator activity and transcription.
intD protein networkhttps://string-db.org/network/511145.b0537DLP12 prophage; Integrase from the cryptic lambdoic prophage DLP12. Integrase is necessary for integration of the phage into the host genome by site- specific recombination. In conjunction with e [...]
insE1-3 protein networkhttps://string-db.org/network/511145.b0540Pseudogene, DLP12 prophage;Phage or Prophage Related.
insF1-3 protein networkhttps://string-db.org/network/511145.b0541IS3 transposase B.
emrE protein networkhttps://string-db.org/network/511145.b0543DLP12 prophage; Multidrug transporter that expels positively charged hydrophobic drugs across the inner membrane of E.coli., thereby conferring resistance to a wide range of toxic compounds. The [...]
ybcK protein networkhttps://string-db.org/network/511145.b0544DLP12 prophage; putative recombinase.
ybcL protein networkhttps://string-db.org/network/511145.b0545Inactive polymorphonuclear leukocyte migration suppressor; DLP12 prophage; UPF0098 family secreted protein.
ybcM protein networkhttps://string-db.org/network/511145.b0546DLP12 prophage; Putative ARAC-type regulatory protein.
ybcN protein networkhttps://string-db.org/network/511145.b0547DLP12 prophage; uncharacterized protein.
ninE protein networkhttps://string-db.org/network/511145.b0548DLP12 prophage; Similar to phage 82 and lambda proteins.
ybcO protein networkhttps://string-db.org/network/511145.b0549DLP12 prophage; Based on its fold and a conserved His residue, has been predicted to be a nuclease; Belongs to the YbcO family.
rusA protein networkhttps://string-db.org/network/511145.b0550DLP12 prophage; Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four- [...]
quuD protein networkhttps://string-db.org/network/511145.b0551DLP12 prophage; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent [...]
insH1-2 protein networkhttps://string-db.org/network/511145.b0552DLP12 prophage; truncated outer membrane porin (pseudogene);IS, phage, Tn; Phage or Prophage Related; outer membrane porin protein; locus of qsr prophage.
essD protein networkhttps://string-db.org/network/511145.b0554DLP12 prophage; putative phage lysis protein.
rrrD protein networkhttps://string-db.org/network/511145.b0555DLP12 prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate; Belongs to the glyco [...]
rzpD protein networkhttps://string-db.org/network/511145.b0556DLP12 prophage; Necessary for host cell lysis. It is believed to code for an endopeptidase that cleaves the amino-carboxyl cross-link between the diaminopimelic acid and D-alanine residues in the [...]
borD protein networkhttps://string-db.org/network/511145.b0557DLP12 prophage; Bacteriophage lambda Bor protein homolog; Belongs to the lambda phage bor family.
ybcV protein networkhttps://string-db.org/network/511145.b0558DLP12 prophage; Putative an envelop protein.
ybcW protein networkhttps://string-db.org/network/511145.b0559DLP12 prophage; uncharacterized protein.
nohD protein networkhttps://string-db.org/network/511145.b0560DLP12 prophage; Bacteriophage DNA packaging protein.
appY protein networkhttps://string-db.org/network/511145.b0564HTH-type transcriptional regulator AppY; Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a [...]
ompT protein networkhttps://string-db.org/network/511145.b0565DLP12 prophage; Protease that can cleave T7 RNA polymerase, ferric enterobactin receptor protein (FEP), antimicrobial peptide protamine and other proteins. This protease has a specificity for pai [...]
envY protein networkhttps://string-db.org/network/511145.b0566Porin thermoregulatory transcriptional activator; Influences the temperature-dependent expression of several E.coli envelope proteins, most notably the porins OmpF and OmpC and the lambda recepto [...]
ybcH protein networkhttps://string-db.org/network/511145.b0567PRK09936 family protein.
nfrA protein networkhttps://string-db.org/network/511145.b0568Bacteriophage N4 receptor, outer membrane subunit; (Microbial infection) Allows N4 phage attachment by binding to the viral non-contractile sheath protein.
nfrB protein networkhttps://string-db.org/network/511145.b0569Bacteriophage N4 receptor, inner membrane subunit; Required for bacteriophage N4 adsorption. May be a component of the phage receptor.
cusS protein networkhttps://string-db.org/network/511145.b0570Copper-sensing histidine kinase in two-component regulatory system with CusR; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Acts as a copper/s [...]
cusR protein networkhttps://string-db.org/network/511145.b0571Response regulator in two-component regulatory system with CusS; Member of the two-component regulatory system CusS/CusR involved in response to copper and silver. Activates the expression of cus [...]
cusC protein networkhttps://string-db.org/network/511145.b0572Copper/silver efflux system, outer membrane component; Forms pores that allow passive diffusion of cations across the outer membrane. Part of a cation efflux system that mediates resistance to co [...]
cusF protein networkhttps://string-db.org/network/511145.b0573Periplasmic copper- and silver-binding protein; Part of a cation efflux system that mediates resistance to copper and silver. Binds one copper per polypeptide.
cusB protein networkhttps://string-db.org/network/511145.b0574Copper/silver efflux system, membrane fusion protein; Part of a cation efflux system that mediates resistance to copper and silver.
cusA protein networkhttps://string-db.org/network/511145.b0575Copper/silver efflux system, membrane component; Part of a cation efflux system that mediates resistance to copper and silver; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) [...]
pheP protein networkhttps://string-db.org/network/511145.b0576Phenylalanine transporter; Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino a [...]
ybdG protein networkhttps://string-db.org/network/511145.b0577Mechanosensitive channel protein, miniconductance; Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against se [...]
nfsB protein networkhttps://string-db.org/network/511145.b0578Dihydropteridine reductase, NAD(P)H-dependent, oxygen-insensitive; Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two [...]
ybdF protein networkhttps://string-db.org/network/511145.b0579DUF419 family protein.
ybdJ protein networkhttps://string-db.org/network/511145.b0580DUF1158 family putative inner membrane protein.
ybdK protein networkhttps://string-db.org/network/511145.b0581Weak gamma-glutamyl:cysteine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity. However, because of the low catalytic rate, the question remai [...]
insL1-2 protein networkhttps://string-db.org/network/511145.b0582IS186 transposase.
entD protein networkhttps://string-db.org/network/511145.b0583Phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric [...]
fepA protein networkhttps://string-db.org/network/511145.b0584Ferrienterobactin outer membrane transporter; This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to [...]
fes protein networkhttps://string-db.org/network/511145.b0585Enterobactin/ferrienterobactin esterase; Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for me [...]
entF protein networkhttps://string-db.org/network/511145.b0586Enterobactin synthase multienzyme complex component, ATP-dependent; Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that [...]
fepE protein networkhttps://string-db.org/network/511145.b0587Regulator of length of O-antigen component of lipopolysaccharide chains; Part of the ferric enterobactin transport system.
fepC protein networkhttps://string-db.org/network/511145.b0588Ferrienterobactin ABC transporter ATPase; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.
fepG protein networkhttps://string-db.org/network/511145.b0589Iron-enterobactin ABC transporter permease; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the [...]
fepD protein networkhttps://string-db.org/network/511145.b0590Ferrienterobactin ABC transporter permease; Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the [...]
entS protein networkhttps://string-db.org/network/511145.b0591Enterobactin exporter, iron-regulated; Component of an export pathway for enterobactin. Overexpression reduces intracellular arabinose concentrations.
fepB protein networkhttps://string-db.org/network/511145.b0592Ferrienterobactin ABC transporter periplasmic binding protein; Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin.
entC protein networkhttps://string-db.org/network/511145.b0593Isochorismate synthase 1; Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of ch [...]
entE protein networkhttps://string-db.org/network/511145.b05942,3-dihydroxybenzoate-AMP ligase component of enterobactin synthase multienzyme complex; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimer [...]
entB protein networkhttps://string-db.org/network/511145.b0595Isochorismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone se [...]
entA protein networkhttps://string-db.org/network/511145.b05962,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)- [...]
entH protein networkhttps://string-db.org/network/511145.b0597Enterobactin synthesis proofreading thioesterase; Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound exi [...]
cstA protein networkhttps://string-db.org/network/511145.b0598Carbon starvation protein involved in peptide utilization; Involved in peptide utilization during carbon starvation.
ybdH protein networkhttps://string-db.org/network/511145.b0599Putative oxidoreductase; Catalyzes the NADPH-dependent reduction of 2-oxoglutarate and 2-oxobutanoate, leading to the respective 2-hydroxycarboxylate. Cannot use NADH instead of NADPH as a redox [...]
ybdL protein networkhttps://string-db.org/network/511145.b0600Methionine aminotransferase, PLP-dependent; Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine. Belongs to the class-I pyr [...]
ybdM protein networkhttps://string-db.org/network/511145.b0601Spo0J family protein, ParB-like nuclease domain.
ybdN protein networkhttps://string-db.org/network/511145.b0602PAPS reductase-like domain protein.
ybdO protein networkhttps://string-db.org/network/511145.b0603Putative transcriptional regulator LYSR-type; Protein involved in transcription and regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
dsbG protein networkhttps://string-db.org/network/511145.b0604Thiol:disulfide interchange protein, periplasmic; Involved in disulfide bond formation. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, [...]
ahpC protein networkhttps://string-db.org/network/511145.b0605Alkyl hydroperoxide reductase, C22 subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a rol [...]
ahpF protein networkhttps://string-db.org/network/511145.b0606Alkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direc [...]
uspG protein networkhttps://string-db.org/network/511145.b0607Universal stress protein UP12; Has intrinsic autoadenylation and autophosphorylation activities, probably on Ser or Thr residues. Belongs to the universal stress protein A family.
ybdR protein networkhttps://string-db.org/network/511145.b0608Putative oxidoreductase.
rnk protein networkhttps://string-db.org/network/511145.b0610Regulator of nucleoside diphosphate kinase; May act as an anti-Gre factor. Regulates the level of the nucleoside diphosphate kinase Ndk; Belongs to the Rnk family.
rna protein networkhttps://string-db.org/network/511145.b0611Ribonuclease I; One of the few RNases that cleaves the phosphodiester bond between any two nucleotide. Shows a preference for cytidylic or guanylic acid.
citT protein networkhttps://string-db.org/network/511145.b0612Citrate/succinate antiporter; Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C(4)-dicarboxylates and [...]
citG protein networkhttps://string-db.org/network/511145.b06132-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase; Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo- acyl ca [...]
citX protein networkhttps://string-db.org/network/511145.b0614Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the cit [...]
citF protein networkhttps://string-db.org/network/511145.b0615Citrate lyase, citrate-ACP transferase (alpha) subunit; Represents a citrate:acetyl-ACP transferase.
citE protein networkhttps://string-db.org/network/511145.b0616Citrate lyase, citryl-ACP lyase (beta) subunit; Represents a citryl-ACP lyase.
citD protein networkhttps://string-db.org/network/511145.b0617Citrate lyase, acyl carrier (gamma) subunit; Covalent carrier of the coenzyme of citrate lyase; Belongs to the CitD family.
citC protein networkhttps://string-db.org/network/511145.b0618Citrate lyase ligase; Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
citA protein networkhttps://string-db.org/network/511145.b0619Sensory histidine kinase in two-component regulatory system with CitB; Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation [...]
citB protein networkhttps://string-db.org/network/511145.b0620Response regulator in two-component regulatory system with CitA; Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes [...]
dcuC protein networkhttps://string-db.org/network/511145.b0621Anaerobic C4-dicarboxylate transport; Responsible for the transport of C4-dicarboxylates during anaerobic growth; Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
pagP protein networkhttps://string-db.org/network/511145.b0622Phospholipid:lipid A palmitoyltransferase; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursor [...]
cspE protein networkhttps://string-db.org/network/511145.b0623Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus.
flc protein networkhttps://string-db.org/network/511145.b0624Fluoride efflux channel, dual topology membrane protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
tatE protein networkhttps://string-db.org/network/511145.b0627Sec-independent protein translocase protein TatE; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in th [...]
lipA protein networkhttps://string-db.org/network/511145.b0628Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, ther [...]
ybeF protein networkhttps://string-db.org/network/511145.b0629Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
lipB protein networkhttps://string-db.org/network/511145.b0630Octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also ac [...]
ybeD protein networkhttps://string-db.org/network/511145.b0631UPF0250 family protein.
dacA protein networkhttps://string-db.org/network/511145.b0632D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
rlpA protein networkhttps://string-db.org/network/511145.b0633Septal ring protein, suppressor of prc, minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides; Belongs to the RlpA family.
mrdB protein networkhttps://string-db.org/network/511145.b0634Cell wall shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation. Also required for the maintenance of the rod cell shape. Functions probably in conjunctio [...]
mrdA protein networkhttps://string-db.org/network/511145.b0635Penicillin-binding protein 2, transpeptidase involved in peptidoglycan synthesis; Catalyzes cross-linking of the peptidoglycan cell wall. Responsible for the determination of the rod shape of the [...]
rlmH protein networkhttps://string-db.org/network/511145.b063623S rRNA m(3)Psi1915 pseudouridine methyltransferase, SAM-dependent; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. Specific for fully assembled 70S ribosomes [...]
rsfS protein networkhttps://string-db.org/network/511145.b0637Ribosomal silencing factor; Functions as a ribosomal silencing factor. Addition to isolated ribosomal subunits partially inhibits their association, preventing translation. Interacts with ribosom [...]
cobC protein networkhttps://string-db.org/network/511145.b0638Putative alpha-ribazole-5'-P phosphatase; Catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12); involved in the assembly of the nucleotide loop of cobalam [...]
nadD protein networkhttps://string-db.org/network/511145.b0639Nicotinic acid mononucleotide adenylyltransferase, NAD(P)-dependent; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). Belong [...]
holA protein networkhttps://string-db.org/network/511145.b0640DNA polymerase III, delta subunit; Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. [...]
lptE protein networkhttps://string-db.org/network/511145.b0641LPS assembly OM complex LptDE, lipoprotein component; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper ass [...]
leuS protein networkhttps://string-db.org/network/511145.b0642Leucine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family.
ybeL protein networkhttps://string-db.org/network/511145.b0643DUF1451 family protein; Putative alpha helical protein.
ybeQ protein networkhttps://string-db.org/network/511145.b0644Sel1 family TPR-like repeat protein; To E.coli YbeT.
ybeR protein networkhttps://string-db.org/network/511145.b0645Uncharacterized protein; To E.coli YbeU.
djlB protein networkhttps://string-db.org/network/511145.b0646Putative HscC co-chaperone, uncharacterized J domain-containing protein; Putative enzyme of polynucleotide modification; Protein involved in protein folding.
ybeT protein networkhttps://string-db.org/network/511145.b0647Sel1 family TPR-like repeat protein.
ybeU protein networkhttps://string-db.org/network/511145.b0648DUF1266 family protein; Putative tRNA ligase; To E.coli YbeR.
djlC protein networkhttps://string-db.org/network/511145.b0649J domain-containing HscC co-chaperone; Hsc56.
hscC protein networkhttps://string-db.org/network/511145.b0650Hsp70 family chaperone Hsc62; Probable chaperone. Has ATPase activity. Not stimulated by DnaJ.
rihA protein networkhttps://string-db.org/network/511145.b0651Ribonucleoside hydrolase 1; Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively.
gltL protein networkhttps://string-db.org/network/511145.b0652Glutamate/aspartate ABC transporter ATPase; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for energy coupling to the transport syste [...]
gltK protein networkhttps://string-db.org/network/511145.b0653Glutamate/aspartate ABC transporter permease; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate a [...]
gltJ protein networkhttps://string-db.org/network/511145.b0654Glutamate/aspartate ABC transporter permease; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Probably responsible for the translocation of the substrate a [...]
gltI protein networkhttps://string-db.org/network/511145.b0655Glutamate/aspartate periplasmic binding protein; Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate.
insH1-3 protein networkhttps://string-db.org/network/511145.b0656IS5 transposase and trans-activator.
lnt protein networkhttps://string-db.org/network/511145.b0657Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. Utilizes a two-step reac [...]
ybeX protein networkhttps://string-db.org/network/511145.b0658Putative ion transport; Plays a role in the transport of magnesium and cobalt ions.
ybeY protein networkhttps://string-db.org/network/511145.b0659ssRNA-specific endoribonuclease; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Acts tog [...]
ybeZ protein networkhttps://string-db.org/network/511145.b0660Heat shock protein, putative NTPase; Putative ATP-binding protein in pho regulon; Belongs to the PhoH family.
miaB protein networkhttps://string-db.org/network/511145.b0661tRNA-i(6)A37 methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at po [...]
ubiF protein networkhttps://string-db.org/network/511145.b06622-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase; Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
asnB protein networkhttps://string-db.org/network/511145.b0674Asparagine synthetase B; Catalyzes the ATP-dependent conversion of aspartate into asparagine, using glutamine as a source of nitrogen. Can also use ammonia as the nitrogen source in vitro, albeit [...]
umpH protein networkhttps://string-db.org/network/511145.b0675UMP phosphatase; Catalyzes the dephosphorylation of an unusually broad range of substrate including deoxyribo- and ribonucleoside tri-, di-, and monophosphates, as well as polyphosphate and gluco [...]
nagC protein networkhttps://string-db.org/network/511145.b0676N-acetylglucosamine-inducible nag divergent operon transcriptional repressor; Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the [...]
nagA protein networkhttps://string-db.org/network/511145.b0677N-acetylglucosamine-6-phosphate deacetylase; Involved in the first step in the biosynthesis of amino- sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N- acetylglucosamine-6-p [...]
nagB protein networkhttps://string-db.org/network/511145.b0678Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glu [...]
nagE protein networkhttps://string-db.org/network/511145.b0679N-acetyl glucosamine specific PTS enzyme IIC, IIB, and IIA components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, [...]
glnS protein networkhttps://string-db.org/network/511145.b0680Glutamine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
chiP protein networkhttps://string-db.org/network/511145.b0681Chitoporin, uptake of chitosugars; Involved in the uptake of chitosugars.
chiQ protein networkhttps://string-db.org/network/511145.b0682Chitosugar-induced verified lipoprotein.
fur protein networkhttps://string-db.org/network/511145.b0683Ferric iron uptake regulon transcriptional repressor; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expr [...]
fldA protein networkhttps://string-db.org/network/511145.b0684Flavodoxin 1; Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.
ybfE protein networkhttps://string-db.org/network/511145.b0685LexA-regulated protein, CopB family; Protein involved in SOS response.
ybfF protein networkhttps://string-db.org/network/511145.b0686acyl-CoA esterase; Displays esterase activity toward palmitoyl-CoA, malonyl-CoA and pNP-butyrate.
seqA protein networkhttps://string-db.org/network/511145.b0687Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs ex [...]
pgm protein networkhttps://string-db.org/network/511145.b0688Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family.
ybfP protein networkhttps://string-db.org/network/511145.b0689Lipoprotein; Putative pectinase.
potE protein networkhttps://string-db.org/network/511145.b0692Putrescine transporter PotE; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine [...]
speF protein networkhttps://string-db.org/network/511145.b0693Ornithine decarboxylase isozyme, inducible; Protein involved in polyamine biosynthetic process; Belongs to the Orn/Lys/Arg decarboxylase class-I family.
kdpE protein networkhttps://string-db.org/network/511145.b0694Response regulator in two-component regulatory system with KdpD; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp operon.
kdpD protein networkhttps://string-db.org/network/511145.b0695Fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein; Member of the two-component regulatory system KdpD/KdpE involved in the regulation of the kdp [...]
kdpC protein networkhttps://string-db.org/network/511145.b0696Potassium translocating ATPase, subunit C; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport [...]
kdpB protein networkhttps://string-db.org/network/511145.b0697Potassium translocating ATPase, subunit B; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport [...]
kdpA protein networkhttps://string-db.org/network/511145.b0698Potassium translocating ATPase, subunit A; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport [...]
ybfA protein networkhttps://string-db.org/network/511145.b0699DUF2517 family protein.
rhsC protein networkhttps://string-db.org/network/511145.b0700Rhs protein with putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell.
ybfB protein networkhttps://string-db.org/network/511145.b0702Putative membrane protein.
ybfC protein networkhttps://string-db.org/network/511145.b0704Uncharacterized protein YbfC; Pseudogene, Rhs family.
ybfD protein networkhttps://string-db.org/network/511145.b0706H repeat-associated putative transposase YbfD; Pseudogene, DDE domain transposase family;putative factor; Not classified; putative receptor protein; Belongs to the transposase 11 family.
ybgA protein networkhttps://string-db.org/network/511145.b0707DUF1722 family protein.
phr protein networkhttps://string-db.org/network/511145.b0708Deoxyribodipyrimidine photolyase, FAD-binding; Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in [...]
dtpD protein networkhttps://string-db.org/network/511145.b0709Dipeptide and tripeptide permease D; Probable proton-dependent permease that transports dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpD subfamily.
ybgI protein networkhttps://string-db.org/network/511145.b0710NIF3 family metal-binding protein; Provides significant protection from radiation damage and may be involved in the degradation of radiation-damaged nucleotides.
ybgJ protein networkhttps://string-db.org/network/511145.b0711Putative allophanate hydrolase, subunit 1; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Belongs to the PxpB family.
ybgK protein networkhttps://string-db.org/network/511145.b0712Putative allophanate hydrolase, subunit 2; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Belongs to the PxpC family.
ybgL protein networkhttps://string-db.org/network/511145.b0713UPF0271 family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. Belongs to the LamB/PxpA family.
nei protein networkhttps://string-db.org/network/511145.b0714Endonuclease VIII and 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recog [...]
abrB protein networkhttps://string-db.org/network/511145.b0715Regulator of aidB expression; Seems to be involved in the regulation of AidB; Belongs to the AbrB family.
ybgO protein networkhttps://string-db.org/network/511145.b0716Putative fimbrial protein; May be involved in a fimbrial system chaperoned by YbgP and exported by YbgQ.
ybgP protein networkhttps://string-db.org/network/511145.b0717Putative periplasmic pilin chaperone; Could be required for the biogenesis of the putative YbgD fimbria; Belongs to the periplasmic pilus chaperone family.
ybgQ protein networkhttps://string-db.org/network/511145.b0718Putative outer membrane protein; Could be involved in the export and assembly of the putative YbgD fimbrial subunit across the outer membrane; Belongs to the fimbrial export usher family.
ybgD protein networkhttps://string-db.org/network/511145.b0719Putative fimbrial-like protein; Belongs to the fimbrial protein family.
gltA protein networkhttps://string-db.org/network/511145.b0720Citrate synthase; Protein involved in tricarboxylic acid cycle and anaerobic respiration; Belongs to the citrate synthase family.
sdhC protein networkhttps://string-db.org/network/511145.b0721Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH); Belongs to the cytochrome b560 family.
sdhD protein networkhttps://string-db.org/network/511145.b0722Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
sdhA protein networkhttps://string-db.org/network/511145.b0723Succinate dehydrogenase, flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reduc [...]
sdhB protein networkhttps://string-db.org/network/511145.b0724Succinate dehydrogenase, FeS subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is u [...]
sucA protein networkhttps://string-db.org/network/511145.b07262-oxoglutarate decarboxylase, thiamine triphosphate-binding; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step [...]
sucB protein networkhttps://string-db.org/network/511145.b0727Dihydrolipoyltranssuccinase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
sucC protein networkhttps://string-db.org/network/511145.b0728succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus rep [...]
sucD protein networkhttps://string-db.org/network/511145.b0729succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or [...]
mngR protein networkhttps://string-db.org/network/511145.b0730Transcriptional repressor for the mannosyl-D-glycerate catabolic operon; Represses mngA and mngB. Regulates its own expression.
mngA protein networkhttps://string-db.org/network/511145.b0731Fused 2-O-a-mannosyl-D-glycerate specific PTS enzymes: IIA component/IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydra [...]
mngB protein networkhttps://string-db.org/network/511145.b0732Alpha-mannosidase; May hydrolyze 6-phospho-mannosyl-D-glycerate to mannose-6- phosphate and glycerate; Belongs to the glycosyl hydrolase 38 family.
cydA protein networkhttps://string-db.org/network/511145.b0733Cytochrome d terminal oxidase, subunit I; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobic [...]
cydB protein networkhttps://string-db.org/network/511145.b0734Cytochrome d terminal oxidase, subunit II; A terminal oxidase that produces a proton motive force by the vectorial transfer of protons across the inner membrane. It is the component of the aerobi [...]
ybgE protein networkhttps://string-db.org/network/511145.b0735Putative inner membrane protein in cydABX-ybgE operon.
ybgC protein networkhttps://string-db.org/network/511145.b0736acyl-CoA thioester hydrolase; Thioesterase that appears to be involved in phospholipid metabolism. Some specific acyl-ACPs could be physiological substrates. Displays acyl-CoA thioesterase activi [...]
tolQ protein networkhttps://string-db.org/network/511145.b0737Membrane spanning protein in TolA-TolQ-TolR complex; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer memb [...]
tolR protein networkhttps://string-db.org/network/511145.b0738Membrane spanning protein in TolA-TolQ-TolR complex; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer memb [...]
tolA protein networkhttps://string-db.org/network/511145.b0739Membrane anchored protein in TolA-TolQ-TolR complex; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer memb [...]
tolB protein networkhttps://string-db.org/network/511145.b0740Periplasmic protein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a [...]
pal protein networkhttps://string-db.org/network/511145.b0741Peptidoglycan-associated outer membrane lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer memb [...]
ybgF protein networkhttps://string-db.org/network/511145.b0742Periplasmic TolA-binding protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division. Promotes physical and functional coordination of the PBP1B [...]
nadA protein networkhttps://string-db.org/network/511145.b0750Quinolinate synthase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. Belongs to the quinolinate synthase A family. Type 1 subfamily.
pnuC protein networkhttps://string-db.org/network/511145.b0751Nicotinamide riboside transporter; Required for nicotinamide riboside transport across the inner membrane.
zitB protein networkhttps://string-db.org/network/511145.b0752Zinc efflux system; Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to z [...]
ybgS protein networkhttps://string-db.org/network/511145.b0753Putative homeobox protein.
aroG protein networkhttps://string-db.org/network/511145.b07543-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy- [...]
gpmA protein networkhttps://string-db.org/network/511145.b0755Phosphoglyceromutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
galM protein networkhttps://string-db.org/network/511145.b0756Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.
galK protein networkhttps://string-db.org/network/511145.b0757Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). To a lesser extent, is also able to phosphorylate 2-deoxy-D-ga [...]
galT protein networkhttps://string-db.org/network/511145.b0758Galactose-1-phosphate uridylyltransferase; Protein involved in cell surface antigen activity, host-interacting, galactose metabolic process, colanic acid biosynthetic process, carbohydrate catabo [...]
galE protein networkhttps://string-db.org/network/511145.b0759UDP-galactose-4-epimerase; Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduct [...]
modF protein networkhttps://string-db.org/network/511145.b0760Molybdate ABC transporter ATPase; Probably not involved in the transport of molybdenum into the cell; Belongs to the ABC transporter superfamily.
modE protein networkhttps://string-db.org/network/511145.b0761Transcriptional repressor for the molybdenum transport operon modABC; Functions as an intracellular molybdate sensor. The ModE-Mo complex acts as a repressor of the modABC operon, which is involv [...]
acrZ protein networkhttps://string-db.org/network/511145.b0762AcrAB-TolC efflux pump accessory protein, membrane-associated; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required [...]
modA protein networkhttps://string-db.org/network/511145.b0763Molybdate ABC transporter periplasmic binding protein; Part of the ABC transporter complex ModABC involved in the transport of molybdenum into the cell. Binds molybdate with high affinity in vitr [...]
modB protein networkhttps://string-db.org/network/511145.b0764Molybdate ABC transporter permease; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs [...]
modC protein networkhttps://string-db.org/network/511145.b0765Molybdate ABC transporter ATPase; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter [...]
ybhA protein networkhttps://string-db.org/network/511145.b0766Pyridoxal phosphate (PLP) phosphatase; Catalyzes the dephosphorylation of pyridoxal-phosphate (PLP). Can also hydrolyze erythrose-4-phosphate (Ery4P) and fructose-1,6-bis- phosphate (Fru1,6bisP); [...]
pgl protein networkhttps://string-db.org/network/511145.b07676-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.
ybhD protein networkhttps://string-db.org/network/511145.b0768Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
ybhH protein networkhttps://string-db.org/network/511145.b0769Putative PrpF family isomerase; Belongs to the PrpF family.
ybhI protein networkhttps://string-db.org/network/511145.b0770Putative DASS family tricarboxylate or dicarboxylate transporter; Putative membrane pump protein.
ybhJ protein networkhttps://string-db.org/network/511145.b0771Aconitase family protein; Putative enzyme.
ybhC protein networkhttps://string-db.org/network/511145.b0772acyl-CoA thioesterase, lipoprotein; Putative thioesterase. Does not bind pectin, and has no pectinesterase activity; Belongs to the pectinesterase family.
ybhB protein networkhttps://string-db.org/network/511145.b0773Kinase inhibitor homolog, UPF0098 family; Belongs to the UPF0098 family.
bioA protein networkhttps://string-db.org/network/511145.b07747,8-diaminopelargonic acid synthase, PLP-dependent; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diamino [...]
bioB protein networkhttps://string-db.org/network/511145.b0775Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
bioF protein networkhttps://string-db.org/network/511145.b07768-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and [...]
bioC protein networkhttps://string-db.org/network/511145.b0777malonyl-ACP O-methyltransferase, SAM-dependent; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It a [...]
bioD protein networkhttps://string-db.org/network/511145.b0778Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ur [...]
uvrB protein networkhttps://string-db.org/network/511145.b0779Exision nuclease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex co [...]
ybhK protein networkhttps://string-db.org/network/511145.b0780Putative CofD superfamily transferase; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.
moaA protein networkhttps://string-db.org/network/511145.b0781Molybdopterin biosynthesis protein A; Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z).
moaB protein networkhttps://string-db.org/network/511145.b0782Inactive molybdopterin adenylyltransferase; May be involved in the biosynthesis of molybdopterin. Can bind GTP and has low GTPase activity. Can bind MPT, but has no MPT adenylyl transferase activ [...]
moaC protein networkhttps://string-db.org/network/511145.b0783Molybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
moaD protein networkhttps://string-db.org/network/511145.b0784Molybdopterin synthase, small subunit; Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin. Belongs to the MoaD family.
moaE protein networkhttps://string-db.org/network/511145.b0785Molybdopterin synthase, large subunit; Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. Th [...]
ybhL protein networkhttps://string-db.org/network/511145.b0786Putative acetate transporter; BAX Inhibitor-1 family inner membrane protein.
ybhM protein networkhttps://string-db.org/network/511145.b0787BAX Inhibitor-1 family inner membrane protein.
ybhN protein networkhttps://string-db.org/network/511145.b0788UPF0104 family inner membrane protein.
clsB protein networkhttps://string-db.org/network/511145.b0789Cardiolipin synthase 2; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Can also cataly [...]
ybhP protein networkhttps://string-db.org/network/511145.b0790Endo/exonuclease/phosphatase family protein; Protein involved in DNA catabolic process.
ybhQ protein networkhttps://string-db.org/network/511145.b0791Inner membrane protein.
ybhR protein networkhttps://string-db.org/network/511145.b0792Putative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the [...]
ybhS protein networkhttps://string-db.org/network/511145.b0793Putative ABC transporter permease; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably involved in the translocation of the substrate across the [...]
ybhF protein networkhttps://string-db.org/network/511145.b0794Putative ABC transporter ATPase; Part of the ABC transporter complex YbhFSR that could be involved in efflux of cefoperazone. Probably responsible for energy coupling to the transport system.
ybhG protein networkhttps://string-db.org/network/511145.b0795Putative membrane fusion protein (MFP) component of efflux pump, membrane anchor; Could be involved in the sensitivity control to chloramphenicol; Belongs to the UPF0194 family.
ybiH protein networkhttps://string-db.org/network/511145.b0796DUF1956 domain-containing tetR family putative transcriptional regulator; Regulates transcription of the cecR-ybhGFSR operon and the rhlE gene, which altogether are involved in the control of sen [...]
rhlE protein networkhttps://string-db.org/network/511145.b0797ATP-dependent RNA helicase; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. May play a role in the interconversion of ribo [...]
ybiA protein networkhttps://string-db.org/network/511145.b0798DUF1768 family protein; Catalyzes the hydrolysis of the N-glycosidic bond in the first two intermediates of riboflavin biosynthesis, which are highly reactive metabolites, yielding relatively inn [...]
dinG protein networkhttps://string-db.org/network/511145.b0799ATP-dependent DNA helicase; DNA-dependent ATPase and 5'-3' DNA helicase. Can also unwind DNA-RNA hybrid duplexes. Is active on D-loops and R-loops, and on forked structures. May be involved in re [...]
ybiB protein networkhttps://string-db.org/network/511145.b0800Putative family 3 glycosyltransferase; Putative enzyme; Belongs to the anthranilate phosphoribosyltransferase family.
ybiC protein networkhttps://string-db.org/network/511145.b0801Putative dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a [...]
ybiJ protein networkhttps://string-db.org/network/511145.b0802DUF1471 family putative periplasmic protein.
ybiI protein networkhttps://string-db.org/network/511145.b0803DksA-type zinc finger protein.
ybiX protein networkhttps://string-db.org/network/511145.b0804Fe(II)-dependent oxygenase superfamily protein; Putative enzyme.
fiu protein networkhttps://string-db.org/network/511145.b0805Catecholate siderophore receptor; Involved in the active transport across the outer membrane of iron complexed with catecholate siderophores such as dihydroxybenzoylserine and dihydroxybenzoate. [...]
mcbA protein networkhttps://string-db.org/network/511145.b0806Colanic acid mucoidy stimulation protein; Affects biofilm formation and mucoidy.
rlmF protein networkhttps://string-db.org/network/511145.b080723S rRNA m(6)A1618 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 1618 of 23S rRNA; Belongs to the methyltransferase superfamily. METTL16/RlmF family.
ybiO protein networkhttps://string-db.org/network/511145.b0808Mechanosensitive channel protein, intermediate conductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Belongs to the MscS (TC 1.A.23) fami [...]
glnQ protein networkhttps://string-db.org/network/511145.b0809Glutamine transporter subunit; Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system; Belongs to the ABC transport [...]
glnP protein networkhttps://string-db.org/network/511145.b0810Glutamine transporter subunit; Part of the binding-protein-dependent transport system for glutamine; probably responsible for the translocation of the substrate across the membrane.
glnH protein networkhttps://string-db.org/network/511145.b0811Glutamine transporter subunit; Involved in a glutamine-transport system GlnHPQ.
dps protein networkhttps://string-db.org/network/511145.b0812Fe-binding and storage protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed a [...]
rhtA protein networkhttps://string-db.org/network/511145.b0813Threonine and homoserine efflux system; Involved in the efflux of threonine and homoserine. Can also export other amino acids such as proline, serine, histidine and cysteine; Belongs to the drug/ [...]
ompX protein networkhttps://string-db.org/network/511145.b0814Outer membrane protein X; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpX family.
opgE protein networkhttps://string-db.org/network/511145.b0815OPG biosynthetic transmembrane phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the osmoregulated periplasmic glucan (OPG) backbone.
mntR protein networkhttps://string-db.org/network/511145.b0817Mn(2+)-responsive manganese regulon transcriptional regulator; In the presence of manganese, represses expression of mntH and mntS. Up-regulates expression of mntP.
ybiR protein networkhttps://string-db.org/network/511145.b0818Putative transporter.
ldtB protein networkhttps://string-db.org/network/511145.b0819L,D-transpeptidase linking Lpp to murein; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via [...]
ybiT protein networkhttps://string-db.org/network/511145.b0820ABC-F family putative regulatory ATPase; Putative ATP-binding component of a transport system.
ybiU protein networkhttps://string-db.org/network/511145.b0821DUF1479 family protein.
ybiV protein networkhttps://string-db.org/network/511145.b0822Sugar phosphatase; Catalyzes the hydrolysis of sugar phosphate to sugar and inorganic phosphate. Has a wide substrate specificity catalyzing the hydrolysis of ribose-5-phosphate, glucose-6-phosph [...]
ybiW protein networkhttps://string-db.org/network/511145.b0823Putative pyruvate formate lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family.
ybiY protein networkhttps://string-db.org/network/511145.b0824Putative pyruvate formate lyase activating enzyme; Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and redu [...]
fsaA protein networkhttps://string-db.org/network/511145.b0825Fructose-6-phosphate aldolase 1; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize [...]
moeB protein networkhttps://string-db.org/network/511145.b0826Molybdopterin synthase sulfurylase; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD.
moeA protein networkhttps://string-db.org/network/511145.b0827Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.
iaaA protein networkhttps://string-db.org/network/511145.b0828Isoaspartyl peptidase; Degrades proteins damaged by L-isoaspartyl residue formation (also known as beta-Asp residues). Degrades L-isoaspartyl-containing di- and maybe also tripeptides. Also has L [...]
gsiA protein networkhttps://string-db.org/network/511145.b0829Glutathione ABC transporter ATPase; Part of the ABC transporter complex GsiABCD involved in glutathione import. Responsible for energy coupling to the transport system.
gsiB protein networkhttps://string-db.org/network/511145.b0830Glutathione ABC transporter periplasmic binding protein; Part of the ABC transporter complex GsiABCD involved in glutathione import. Binds glutathione ; Belongs to the bacterial solute-binding pr [...]
gsiC protein networkhttps://string-db.org/network/511145.b0831Glutathione ABC transporter permease; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
gsiD protein networkhttps://string-db.org/network/511145.b0832Glutathione ABC transporter permease; Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
yliE protein networkhttps://string-db.org/network/511145.b0833Putative membrane-anchored cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Overexpression reduces bi [...]
yliF protein networkhttps://string-db.org/network/511145.b0834Putative membrane-anchored diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
rimO protein networkhttps://string-db.org/network/511145.b0835Ribosomal protein S12 methylthiotransferase; Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12.
bssR protein networkhttps://string-db.org/network/511145.b0836Repressor of biofilm formation by indole transport regulation; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several g [...]
yliI protein networkhttps://string-db.org/network/511145.b0837Soluble aldose sugar dehydrogenase; Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D- [...]
gstB protein networkhttps://string-db.org/network/511145.b0838Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes the glutathione-dependent dehalogenation of bromoac [...]
dacC protein networkhttps://string-db.org/network/511145.b0839D-alanyl-D-alanine carboxypeptidase; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
deoR protein networkhttps://string-db.org/network/511145.b0840Deoxyribose-5-phosphate-inducible deoxyribose operon transcriptional repressor; This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and de [...]
ybjG protein networkhttps://string-db.org/network/511145.b0841Undecaprenyl pyrophosphate phosphatase; Overexpression leads to increased undecaprenyl diphosphatase activity and to increased resistance to bacitracin. May have a preferred substrate other than [...]
mdfA protein networkhttps://string-db.org/network/511145.b0842Multidrug efflux system protein; Efflux pump driven by the proton motive force. Confers resistance to a broad spectrum of chemically unrelated drugs. Confers resistance to a diverse group of cati [...]
ybjH protein networkhttps://string-db.org/network/511145.b0843Uncharacterized protein.
ybjI protein networkhttps://string-db.org/network/511145.b08445-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase; Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D- ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis p [...]
ybjJ protein networkhttps://string-db.org/network/511145.b0845Putative drug efflux MFS transporter, inner membrane protein; Putative DEOR-type transcriptional regulator.
rcdA protein networkhttps://string-db.org/network/511145.b0846Transcriptional regulator of csgD and ybiJI; Regulates the expression of a number of genes involved in biofilm formation and stress response. Target genes include six stress- response transcripti [...]
ybjL protein networkhttps://string-db.org/network/511145.b0847Putative transport protein.
ybjM protein networkhttps://string-db.org/network/511145.b0848Inner membrane protein.
grxA protein networkhttps://string-db.org/network/511145.b0849Glutaredoxin 1, redox coenzyme for ribonucleotide reductase (RNR1a); The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzy [...]
ybjC protein networkhttps://string-db.org/network/511145.b0850DUF1418 family protein.
nfsA protein networkhttps://string-db.org/network/511145.b0851Nitroreductase A, NADPH-dependent, FMN-dependent; Catalyzes the reduction of nitroaromatic compounds using NADPH. Has a broad electron acceptor specificity. Reduces nitrofurazone by a ping-pong b [...]
rimK protein networkhttps://string-db.org/network/511145.b0852Ribosomal protein S6 modification protein; Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (R [...]
ybjN protein networkhttps://string-db.org/network/511145.b0853Negative regulator of motility; Putative sensory transduction regulator.
potF protein networkhttps://string-db.org/network/511145.b0854Putrescine ABC transporter periplasmic binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein. Belongs to the bacterial [...]
potG protein networkhttps://string-db.org/network/511145.b0855Putrescine ABC transporter ATPase; Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system; Belongs to the ABC tran [...]
potH protein networkhttps://string-db.org/network/511145.b0856Putrescine ABC transporter permease; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the binding-protein-dependent transport system permease fami [...]
potI protein networkhttps://string-db.org/network/511145.b0857Putrescine ABC transporter permease; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the binding-protein-dependent transport system permease fami [...]
ybjO protein networkhttps://string-db.org/network/511145.b0858DUF2593 family inner membrane protein.
rlmC protein networkhttps://string-db.org/network/511145.b085923S rRNA m(5)U747 methyltransferase, SAM-dependent; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase sup [...]
artJ protein networkhttps://string-db.org/network/511145.b0860Arginine ABC transporter periplasmic binding protein; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Binds L-arginine with high affinity.
artM protein networkhttps://string-db.org/network/511145.b0861Arginine ABC transporter permease; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane.
artQ protein networkhttps://string-db.org/network/511145.b0862Arginine ABC transporter permease; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane.
artI protein networkhttps://string-db.org/network/511145.b0863Arginine transporter subunit; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport.
artP protein networkhttps://string-db.org/network/511145.b0864Arginine ABC transporter ATPase; Part of the ABC transporter complex ArtPIQMJ involved in arginine transport. Probably responsible for energy coupling to the transport system.
ybjP protein networkhttps://string-db.org/network/511145.b0865Putative lipoprotein.
ybjQ protein networkhttps://string-db.org/network/511145.b0866UPF0145 family protein.
amiD protein networkhttps://string-db.org/network/511145.b08671,6-anhydro-N-acetylmuramyl-L-alanine amidase, Zn-dependent; OM lipoprotein.
ybjS protein networkhttps://string-db.org/network/511145.b0868Putative NAD(P)H-dependent oxidoreductase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
ybjT protein networkhttps://string-db.org/network/511145.b0869Putative NAD-dependent oxidoreductase.
ltaE protein networkhttps://string-db.org/network/511145.b0870L-allo-threonine aldolase, PLP-dependent; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. L-threo-phenylserine and L-erythro- phenylserine are also good su [...]
poxB protein networkhttps://string-db.org/network/511145.b0871Pyruvate dehydrogenase, thiamine triphosphate-binding, FAD-binding; Pyruvate oxidase; Protein involved in carbohydrate catabolic process and pyruvate catabolic process; Belongs to the TPP enzyme [...]
hcr protein networkhttps://string-db.org/network/511145.b0872HCP oxidoreductase, NADH-dependent; NADH oxidoreductase acting in concert with HCP.
hcp protein networkhttps://string-db.org/network/511145.b0873Hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylh [...]
ybjE protein networkhttps://string-db.org/network/511145.b0874Putative transporter; Mediates export of lysine; Belongs to the LysO family.
aqpZ protein networkhttps://string-db.org/network/511145.b0875Aquaporin Z; Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in ra [...]
ybjD protein networkhttps://string-db.org/network/511145.b0876Putative OLD family ATP-dependent endonuclease; DUF2813 family protein.
ybjX protein networkhttps://string-db.org/network/511145.b0877DUF535 family protein; Putative enzyme; To H.influenzae HI_0461.
macA protein networkhttps://string-db.org/network/511145.b0878Macrolide transporter membrane fusion protein (MFP) component; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound stat [...]
macB protein networkhttps://string-db.org/network/511145.b0879Macrolide ABC transporter peremase/ATPase; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in [...]
cspD protein networkhttps://string-db.org/network/511145.b0880Inhibitor of DNA replication, cold shock protein homolog; Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at repl [...]
clpS protein networkhttps://string-db.org/network/511145.b0881Regulatory protein for ClpA substrate specificity; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation.
clpA protein networkhttps://string-db.org/network/511145.b0882ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; ATP-dependent specificity component of the ClpAP protease. It directs the protease to specific subst [...]
infA protein networkhttps://string-db.org/network/511145.b0884Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site. Stabilizes the binding of IF-2 and IF-3 on the 30 [...]
aat protein networkhttps://string-db.org/network/511145.b0885leucyl/phenylalanyl-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-ter [...]
cydC protein networkhttps://string-db.org/network/511145.b0886Glutathione/cysteine ABC transporter export permease/ATPase; Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system; Belongs to the ABC [...]
cydD protein networkhttps://string-db.org/network/511145.b0887Glutathione/cysteine ABC transporter export permease/ATPase; Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system.
trxB protein networkhttps://string-db.org/network/511145.b0888Thioredoxin reductase, FAD/NAD(P)-binding; Thioredoxin reductase; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
lrp protein networkhttps://string-db.org/network/511145.b0889Leucine-responsive global transcriptional regulator; Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for [...]
ftsK protein networkhttps://string-db.org/network/511145.b0890DNA translocase at septal ring sorting daughter chromsomes; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of th [...]
lolA protein networkhttps://string-db.org/network/511145.b0891Lipoprotein chaperone; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal [...]
rarA protein networkhttps://string-db.org/network/511145.b0892Recombination intermediate processing DNA-dependent ATPase; DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
serS protein networkhttps://string-db.org/network/511145.b0893seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further [...]
dmsA protein networkhttps://string-db.org/network/511145.b0894Dimethyl sulfoxide reductase, anaerobic, subunit A; Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). DMSO reductase serves as the terminal reductase under anaerobic [...]
dmsB protein networkhttps://string-db.org/network/511145.b0895Dimethyl sulfoxide reductase, anaerobic, subunit B; Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
dmsC protein networkhttps://string-db.org/network/511145.b0896Dimethyl sulfoxide reductase, anaerobic, subunit C; Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabili [...]
ycaC protein networkhttps://string-db.org/network/511145.b0897Putative isochorismatase family hydrolase; Protein involved in cellular amino acid catabolic process.
ycaD protein networkhttps://string-db.org/network/511145.b0898Putative MFS transporter, inner membrane protein.
ycaM protein networkhttps://string-db.org/network/511145.b0899Putative transporter.
ycaN protein networkhttps://string-db.org/network/511145.b0900Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
ycaK protein networkhttps://string-db.org/network/511145.b0901Putative NAD(P)H-dependent oxidoreductase; Protein involved in electron carrier activity; Belongs to the NAD(P)H dehydrogenase (quinone) family.
pflA protein networkhttps://string-db.org/network/511145.b0902Pyruvate formate-lyase 1-activating enzyme; Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced fla [...]
pflB protein networkhttps://string-db.org/network/511145.b0903Formate acetyltransferase 1; Protein involved in anaerobic respiration and cellular amino acid catabolic process.
focA protein networkhttps://string-db.org/network/511145.b0904Formate channel; Involved in the bidirectional transport of formate; Belongs to the FNT transporter (TC 2.A.44) family.
ycaO protein networkhttps://string-db.org/network/511145.b0905Ribosomal protein S12 methylthiotransferase accessory factor; Involved in beta-methylthiolation of ribosomal protein S12.
ycaP protein networkhttps://string-db.org/network/511145.b0906UPF0702 family putative inner membrane protein.
serC protein networkhttps://string-db.org/network/511145.b09073-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phos [...]
aroA protein networkhttps://string-db.org/network/511145.b09085-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvy [...]
ycaL protein networkhttps://string-db.org/network/511145.b0909Putative peptidase-related chaperone; Involved in the degradation of the LPS-assembly protein LptD. Degrades LptD that have engaged the Bam complex but are stalled at an early step in the outer m [...]
cmk protein networkhttps://string-db.org/network/511145.b0910Cytidylate kinase; ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors. Belongs to the cytidylate kinase family. Type 1 subfamily.
rpsA protein networkhttps://string-db.org/network/511145.b091130S ribosomal subunit protein S1; Required for translation of most natural mRNAs except for leaderless mRNA. Binds mRNA upstream of the Shine- Dalgarno (SD) sequence and helps it bind to the 30S [...]
ihfB protein networkhttps://string-db.org/network/511145.b0912Integration host factor (IHF), DNA-binding protein, beta subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as [...]
ycaI protein networkhttps://string-db.org/network/511145.b0913ComEC family inner membrane protein.
msbA protein networkhttps://string-db.org/network/511145.b0914Lipid ABC transporter permease/ATPase; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore [...]
lpxK protein networkhttps://string-db.org/network/511145.b0915Lipid A 4'kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lip [...]
ycaQ protein networkhttps://string-db.org/network/511145.b0916DUF1006 family protein with C-terminal wHTH domain.
ycaR protein networkhttps://string-db.org/network/511145.b0917Peroxide and acid resistance protein, UPF0434 family; Belongs to the UPF0434 family.
kdsB protein networkhttps://string-db.org/network/511145.b09183-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
ycbJ protein networkhttps://string-db.org/network/511145.b0919Protein kinase-like domain protein.
elyC protein networkhttps://string-db.org/network/511145.b0920Envelope biogenesis factor; Plays a critical role in the metabolism of the essential lipid carrier used for cell wall synthesis.
smtA protein networkhttps://string-db.org/network/511145.b0921Putative S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs [...]
mukF protein networkhttps://string-db.org/network/511145.b0922Chromosome condensin MukBEF, kleisin-like subunit, binds calcium; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregati [...]
mukE protein networkhttps://string-db.org/network/511145.b0923Chromosome condensin MukBEF, MukE localization factor; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by conde [...]
mukB protein networkhttps://string-db.org/network/511145.b0924Chromosome condensin MukBEF, ATPase and DNA-binding subunit; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential [...]
ldtD protein networkhttps://string-db.org/network/511145.b0925Murein L,D-transpeptidase; Responsible, at least in part, for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link. Belongs to the YkuD family.
ycbK protein networkhttps://string-db.org/network/511145.b0926M15A protease-related family periplasmic protein.
ycbL protein networkhttps://string-db.org/network/511145.b0927Putative metal-binding enzyme; Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S- lactoylglutathione to (R)-lactate and glutathione. Plays a minor contribution to methylglyoxal (MG) deto [...]
aspC protein networkhttps://string-db.org/network/511145.b0928Aspartate aminotransferase, PLP-dependent; Aspartate aminotransferase; Protein involved in cellular amino acid catabolic process and aspartate biosynthetic process.
ompF protein networkhttps://string-db.org/network/511145.b0929Outer membrane porin 1a (Ia;b;F); Forms pores that allow passive diffusion of small molecules across the outer membrane. (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane [...]
asnS protein networkhttps://string-db.org/network/511145.b0930Asparagine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
pncB protein networkhttps://string-db.org/network/511145.b0931Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase [...]
pepN protein networkhttps://string-db.org/network/511145.b0932Aminopeptidase N; Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
ssuB protein networkhttps://string-db.org/network/511145.b0933Aliphatic sulfonate ABC transporter ATPase; Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable).
ssuC protein networkhttps://string-db.org/network/511145.b0934Aliphatic sulfonate ABC transporter permease; Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the [...]
ssuD protein networkhttps://string-db.org/network/511145.b0935Alkanesulfonate monooxygenase, FMNH(2)-dependent; Involved in desulfonation of aliphatic sulfonates. Catalyzes the conversion of pentanesulfonic acid to sulfite and pentaldehyde and is able to de [...]
ssuA protein networkhttps://string-db.org/network/511145.b0936Aliphatic sulfonate ABC transporter periplasmic binding protein; Part of a binding-protein-dependent transport system for aliphatic sulfonates. Putative binding protein; Belongs to the bacterial [...]
ssuE protein networkhttps://string-db.org/network/511145.b0937NAD(P)H-dependent FMN reductase; Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin.
elfA protein networkhttps://string-db.org/network/511145.b0938Laminin-binding fimbrin subunit; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this [...]
elfD protein networkhttps://string-db.org/network/511145.b0939Putative periplasmic pilin chaperone; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the El [...]
elfC protein networkhttps://string-db.org/network/511145.b0940Putative outer membrane fimbrial subunit export usher protein; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be involved in [...]
elfG protein networkhttps://string-db.org/network/511145.b0941Putative fimbrial-like adhesin protein; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces.
ycbU protein networkhttps://string-db.org/network/511145.b0942Putative fimbriae protein; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces.
ycbV protein networkhttps://string-db.org/network/511145.b0943Putative fimbrial-like adhesin protein; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces.
ycbF protein networkhttps://string-db.org/network/511145.b0944Putative periplasmic pilin chaperone; Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of fimbri [...]
pyrD protein networkhttps://string-db.org/network/511145.b0945Dihydro-orotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
zapC protein networkhttps://string-db.org/network/511145.b0946FtsZ stabilizer; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protof [...]
ycbX protein networkhttps://string-db.org/network/511145.b09476-N-hydroxylaminopurine detoxification oxidoreductase; Protein involved in electron carrier activity.
rlmL protein networkhttps://string-db.org/network/511145.b094823S rRNA m(2)G2445 and m(7)G2069 methyltransferases, SAM-dependent; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Methylat [...]
uup protein networkhttps://string-db.org/network/511145.b0949Replication regulatory ABC-F family DNA-binding ATPase; Probably plays a role in ribosome assembly or function; overexpression suppresses cold-sensitive growth of a bipA deletion (Probable). May [...]
pqiA protein networkhttps://string-db.org/network/511145.b0950Paraquat-inducible, SoxRS-regulated inner membrane protein; Component of a transport pathway that contributes to membrane integrity; Belongs to the PqiA family.
pqiB protein networkhttps://string-db.org/network/511145.b0951Paraquat-inducible, SoxRS-regulated MCE domain protein; Component of a transport pathway that contributes to membrane integrity. May directly span the intermembrane space, facilitating the transp [...]
pqiC protein networkhttps://string-db.org/network/511145.b0952DUF330 family putative lipoprotein; Component of a transport pathway that contributes to membrane integrity.
rmf protein networkhttps://string-db.org/network/511145.b0953Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an immature dimeric form (90S ribosomes) which are converted to inactive 100S ribosomes (a process called ribosomal [...]
fabA protein networkhttps://string-db.org/network/511145.b0954Beta-hydroxydecanoyl thioester dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and t [...]
ycbZ protein networkhttps://string-db.org/network/511145.b0955Putative ATP-dependent protease; Protein involved in proteolysis.
matP protein networkhttps://string-db.org/network/511145.b0956Ter macrodomain organizer matS-binding protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of d [...]
ompA protein networkhttps://string-db.org/network/511145.b0957Outer membrane protein A (3a;II*;G;d); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to enviro [...]
sulA protein networkhttps://string-db.org/network/511145.b0958SOS cell division inhibitor; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate fi [...]
sxy protein networkhttps://string-db.org/network/511145.b0959CRP-S-dependent promoter expression factor; Induces low levels of natural DNA uptake by inducing transcription of the competence genes (the CRP-S regulon) required for DNA transformation. Inducti [...]
yccS protein networkhttps://string-db.org/network/511145.b0960Putative transporter, FUSC superfamily inner membrane protein.
yccF protein networkhttps://string-db.org/network/511145.b0961DUF307 family inner membrane protein.
helD protein networkhttps://string-db.org/network/511145.b0962DNA helicase IV; Helicase IV catalyzes the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP.
mgsA protein networkhttps://string-db.org/network/511145.b0963Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
yccT protein networkhttps://string-db.org/network/511145.b0964UPF0319 family protein; Belongs to the UPF0319 family.
yccU protein networkhttps://string-db.org/network/511145.b0965Putative CoA-binding protein.
hspQ protein networkhttps://string-db.org/network/511145.b0966Heat shock protein involved in degradation of mutant DnaA; Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.
rlmI protein networkhttps://string-db.org/network/511145.b096723S rRNA m(5)C1962 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. Methylation occurs before assembly of 23S rRNA into 50S subunits; [...]
yccX protein networkhttps://string-db.org/network/511145.b0968Weak acylphosphatase.
tusE protein networkhttps://string-db.org/network/511145.b0969mnm(5)-s(2)U34-tRNA 2-thiolation sulfurtransferase; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could acc [...]
yccA protein networkhttps://string-db.org/network/511145.b0970Modulator of FtsH protease, inner membrane protein; Negatively modulates the activity of the FtsH protease for membrane substrates. Overexpression or stabilizing YccA counteracts the FtsH-mediate [...]
hyaA protein networkhttps://string-db.org/network/511145.b0972Hydrogenase 1, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fe [...]
hyaB protein networkhttps://string-db.org/network/511145.b0973Hydrogenase 1, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD1 is believed to have a role in hydrogen cycling during fe [...]
hyaC protein networkhttps://string-db.org/network/511145.b0974Hydrogenase 1, b-type cytochrome subunit; Probable b-type cytochrome; Belongs to the HupC/HyaC/HydC family.
hyaD protein networkhttps://string-db.org/network/511145.b0975Hydrogenase 1 maturation protease; Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1; Belongs to the peptidase A31 family.
hyaE protein networkhttps://string-db.org/network/511145.b0976Putative HyaA chaperone; Not known. Could form, along with HyaD, a complex involved in the processing of the hydrogenase 1 structural operon.
hyaF protein networkhttps://string-db.org/network/511145.b0977Hydrogenase-1 protein nickel incorporation factor; Not known. Could enhance the incorporation of nickel to the hydrogenase.
cbdA protein networkhttps://string-db.org/network/511145.b0978Cytochrome bd-II oxidase, subunit I; A terminal oxidase that catalyzes quinol-dependent, Na(+)- independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested. G [...]
cbdB protein networkhttps://string-db.org/network/511145.b0979Cytochrome bd-II oxidase, subunit II; A terminal oxidase that catalyzes quinol-dependent, Na(+)- independent oxygen uptake. Prefers menadiol over other quinols although ubiquinol was not tested. [...]
appA protein networkhttps://string-db.org/network/511145.b0980Phosphoanhydride phosphorylase; pH 2.5 acid phosphatase; periplasmic; Protein involved in phosphorus metabolic process and response to starvation.
etk protein networkhttps://string-db.org/network/511145.b0981Tyrosine-protein kinase, role in O-antigen capsule formation; Protein involved in protein modification process; Belongs to the etk/wzc family.
etp protein networkhttps://string-db.org/network/511145.b0982O-antigen capsule forming protein-tyrosine-phosphatase; Dephosphorylates etk; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
gfcE protein networkhttps://string-db.org/network/511145.b0983Putative O-antigen capsule outer membrane auxillary protein export channel; May be involved in polysaccharide transport; Belongs to the BexD/CtrA/VexA family.
gfcD protein networkhttps://string-db.org/network/511145.b0984Putative O-antigen capsule production periplasmic protein.
gfcC protein networkhttps://string-db.org/network/511145.b0985Putative O-antigen capsule production periplasmic protein; To E.coli YjbG.
gfcB protein networkhttps://string-db.org/network/511145.b0986O-antigen capsule production lipoprotein; Putative regulator.
gfcA protein networkhttps://string-db.org/network/511145.b0987O-antigen capsule production threonine-rich inner membrane protein.
insB1-4 protein networkhttps://string-db.org/network/511145.b0988IS1 transposase B; Absolutely required for transposition of IS1.
cspH protein networkhttps://string-db.org/network/511145.b0989Stress protein, member of the CspA-family; Cold shock-like protein; Protein involved in response to temperature stimulus.
cspG protein networkhttps://string-db.org/network/511145.b0990Homolog of Salmonella cold shock protein; Protein involved in response to temperature stimulus.
ymcE protein networkhttps://string-db.org/network/511145.b0991Cold shock gene; Suppresses fabA and ts growth mutation.
yccM protein networkhttps://string-db.org/network/511145.b0992Putative 4Fe-4S membrane protein.
torS protein networkhttps://string-db.org/network/511145.b0993Hybrid sensory histidine kinase in two-component regulatory system with TorR; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxi [...]
torT protein networkhttps://string-db.org/network/511145.b0994Periplasmic sensory protein associated with the TorRS two-component regulatory system; Upon binding a putative inducer it probably interacts with TorS and allows it to play a role in the inductio [...]
torR protein networkhttps://string-db.org/network/511145.b0995Response regulator in two-component regulatory system with TorS; Member of the two-component regulatory system TorS/TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Ph [...]
torC protein networkhttps://string-db.org/network/511145.b0996Trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit; Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorA. Acts by transferring electrons from the me [...]
torA protein networkhttps://string-db.org/network/511145.b0997Trimethylamine N-oxide (TMAO) reductase I, catalytic subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.
torD protein networkhttps://string-db.org/network/511145.b0998TorA-maturation chaperone; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that [...]
cbpM protein networkhttps://string-db.org/network/511145.b0999Modulator of CbpA co-chaperone; Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the [...]
cbpA protein networkhttps://string-db.org/network/511145.b1000DnaK co-chaperone; DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions u [...]
yccE protein networkhttps://string-db.org/network/511145.b1001Uncharacterized protein.
agp protein networkhttps://string-db.org/network/511145.b1002Glucose-1-phosphatase/inositol phosphatase; Absolutely required for the growth of E.coli in a high- phosphate medium containing G-1-P as the sole carbon source; Belongs to the histidine acid phos [...]
yccJ protein networkhttps://string-db.org/network/511145.b1003Uncharacterized protein.
wrbA protein networkhttps://string-db.org/network/511145.b1004NAD(P)H:quinone oxidoreductase; It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces [...]
rutG protein networkhttps://string-db.org/network/511145.b1006Pyrimidine permease; May function as a proton-driven pyrimidine uptake system.
rutF protein networkhttps://string-db.org/network/511145.b1007flavin:NADH reductase; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway. In vitro, the flavin reductase Fre can substitute for the function o [...]
rutE protein networkhttps://string-db.org/network/511145.b1008Putative malonic semialdehyde reductase; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. RutE is apparently supplemented by YdfG. Required in vivo, b [...]
rutD protein networkhttps://string-db.org/network/511145.b1009Putative reactive intermediate detoxifying aminoacrylate hydrolase; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermedia [...]
rutC protein networkhttps://string-db.org/network/511145.b1010Putative aminoacrylate deaminase, reactive intermediate detoxification; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce in vivo, but not in vitr [...]
rutB protein networkhttps://string-db.org/network/511145.b1011Ureidoacrylate amidohydrolase; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate pe [...]
rutA protein networkhttps://string-db.org/network/511145.b1012Pyrimidine oxygenase, FMN-dependent; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves p [...]
rutR protein networkhttps://string-db.org/network/511145.b1013Rut operon transcriptional repressor for; Master transcription regulator which represses the degradation of pyrimidines (rutABCDEFG) and purines (gcl operon) for maintenance of metabolic balance [...]
putA protein networkhttps://string-db.org/network/511145.b1014Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon; In the C-t [...]
putP protein networkhttps://string-db.org/network/511145.b1015Proline:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline. This protein is also capable of using lithium as the transport cation. Also catalyzes the uptake of pr [...]
efeO protein networkhttps://string-db.org/network/511145.b1018Iron uptake system component EfeO; Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component.
efeB protein networkhttps://string-db.org/network/511145.b1019Deferrrochelatase, periplasmic; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Also displays peroxidase activity on guaiaco [...]
phoH protein networkhttps://string-db.org/network/511145.b1020PhoB-dependent, ATP-binding pho regulon component; may be helicase; induced by P starvation; Protein involved in phosphorus metabolic process and response to starvation; Belongs to the PhoH famil [...]
pgaD protein networkhttps://string-db.org/network/511145.b1021Biofilm PGA synthase PgaCD, regulatory subunit; Required for the synthesis of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysaccharide. May assist the glycosyltransferase Pga [...]
pgaC protein networkhttps://string-db.org/network/511145.b1022Biofilm PGA synthase PgaCD, catalytic subunit; Probable N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear [...]
pgaB protein networkhttps://string-db.org/network/511145.b1023poly-beta-1,6-N-acetyl-D-glucosamine (PGA) N-deacetylase outer membrane export lipoprotein; Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D- glucosamine (PGA), a biofilm adhesin polysac [...]
pgaA protein networkhttps://string-db.org/network/511145.b1024Biofilm adhesin polysaccharide PGA secretin; Exports the biofilm adhesin polysaccharide poly-beta-1,6-N- acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be part [...]
ycdT protein networkhttps://string-db.org/network/511145.b1025Diguanylate cyclase, membrane-anchored; Probably catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. Overexpression leads to a strong repression of swimmi [...]
insF1-4 protein networkhttps://string-db.org/network/511145.b1026IS3 transposase B.
insE1-4 protein networkhttps://string-db.org/network/511145.b1027IS3 transposase A.
ycdU protein networkhttps://string-db.org/network/511145.b1029Uncharacterized protein YcdU; Pseudogene.
ghrA protein networkhttps://string-db.org/network/511145.b1033Glyoxylate/hydroxypyruvate reductase A; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Inactive towards 2-oxo-D-gluconate, 2 [...]
ycdX protein networkhttps://string-db.org/network/511145.b1034Alkaline phosphatase; Hydrolyzes p-nitrophenyl phosphate (pNPP) in vitro. Involved in the swarming motility process; Belongs to the PHP family.
ycdY protein networkhttps://string-db.org/network/511145.b1035Redox enzyme maturation protein (REMP) chaperone for YcdX; Acts as a chaperone that increases YcdX activity, maybe by facilitating the correct insertion of the zinc ions into the catalytic site o [...]
ycdZ protein networkhttps://string-db.org/network/511145.b1036DUF1097 family inner membrane protein.
csgG protein networkhttps://string-db.org/network/511145.b1037Curli production assembly/transport outer membrane lipoprotein; May be involved in the biogenesis of curli organelles.
csgF protein networkhttps://string-db.org/network/511145.b1038Curli nucleation outer membrane protein; May be involved in the biogenesis of curli organelles.
csgE protein networkhttps://string-db.org/network/511145.b1039Curlin secretion specificity factor; May be involved in the biogenesis of curli organelles.
csgD protein networkhttps://string-db.org/network/511145.b1040csgBAC operon transcriptional regulator; The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm forma [...]
csgB protein networkhttps://string-db.org/network/511145.b1041Curlin nucleator protein, minor subunit in curli complex; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temper [...]
csgA protein networkhttps://string-db.org/network/511145.b1042Curlin subunit, amyloid curli fibers, cryptic; Curlin is the structural subunit of the curli fimbriae. Curli are coiled surface structures that assemble preferentially at growth temperatures belo [...]
csgC protein networkhttps://string-db.org/network/511145.b1043Curli assembly protein; Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an ex [...]
ymdA protein networkhttps://string-db.org/network/511145.b1044Uncharacterized protein.
ymdB protein networkhttps://string-db.org/network/511145.b1045O-acetyl-ADP-ribose deacetylase; Deacetylates O-acetyl-ADP ribose to yield ADP-ribose and free acetate. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the r [...]
clsC protein networkhttps://string-db.org/network/511145.b1046Stationary phase cardiolipin synthase 3; Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
opgC protein networkhttps://string-db.org/network/511145.b1047OPG biosynthetic transmembrane succinyltransferase; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of t [...]
opgG protein networkhttps://string-db.org/network/511145.b1048OPG biosynthetic periplasmic beta-1,6 branching glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs); Belongs to the OpgD/OpgG family.
opgH protein networkhttps://string-db.org/network/511145.b1049OPG biosynthetic ACP-dependent transmembrane UDP-glucose beta-1,2 glycosyltransferase; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
yceK protein networkhttps://string-db.org/network/511145.b1050Outer membrane integrity lipoprotein; To E.coli YidQ.
msyB protein networkhttps://string-db.org/network/511145.b1051Multicopy suppressor of secY and secA; Could participate in the normal pathway of protein export.
mdtG protein networkhttps://string-db.org/network/511145.b1053Putative drug efflux system protein; Confers resistance to fosfomycin and deoxycholate. Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
lpxL protein networkhttps://string-db.org/network/511145.b1054Lauryl-acyl carrier protein (ACP)-dependent acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). [...]
yceA protein networkhttps://string-db.org/network/511145.b1055Putative rhodanese-related sulfurtransferase; Protein involved in cell cycle; Belongs to the UPF0176 family.
yceI protein networkhttps://string-db.org/network/511145.b1056Periplasmic high pH-inducible lipid-binding protein.
yceJ protein networkhttps://string-db.org/network/511145.b1057Putative cytochrome b561; Protein involved in cytochrome complex assembly; Belongs to the cytochrome b561 family.
yceO protein networkhttps://string-db.org/network/511145.b1058Uncharacterized protein.
solA protein networkhttps://string-db.org/network/511145.b1059N-methyltryptophan oxidase, FAD-binding; Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor s [...]
bssS protein networkhttps://string-db.org/network/511145.b1060Biofilm regulator; Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and s [...]
dinI protein networkhttps://string-db.org/network/511145.b1061DNA damage-inducible protein I; Involved in SOS regulation. Inhibits RecA by preventing RecA to bind ssDNA. Can displace ssDNA from RecA.
pyrC protein networkhttps://string-db.org/network/511145.b1062Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
yceB protein networkhttps://string-db.org/network/511145.b1063Lipoprotein, DUF1439 family.
grxB protein networkhttps://string-db.org/network/511145.b1064Glutaredoxin 2 (Grx2); Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase.
mdtH protein networkhttps://string-db.org/network/511145.b1065Multidrug resistance protein MdtH; Confers resistance to norfloxacin and enoxacin.
rimJ protein networkhttps://string-db.org/network/511145.b1066ribosomal-protein-S5-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S5. Also plays a role in maturation of the 30S ribosomal subunit. Plays a role in the temp [...]
yceH protein networkhttps://string-db.org/network/511145.b1067UPF0502 family protein; Belongs to the UPF0502 family.
yceM protein networkhttps://string-db.org/network/511145.b1068Putative virulence factor; Belongs to the Gfo/Idh/MocA family.
murJ protein networkhttps://string-db.org/network/511145.b1069Putative lipid II flippase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. Belongs to t [...]
flgN protein networkhttps://string-db.org/network/511145.b1070Export chaperone for FlgK and FlgL; Required for the efficient initiation of filament assembly.
flgM protein networkhttps://string-db.org/network/511145.b1071Anti-sigma factor for FliA (sigma 28); Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle cl [...]
flgA protein networkhttps://string-db.org/network/511145.b1072Assembly protein for flagellar basal-body periplasmic P ring; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential fo [...]
flgB protein networkhttps://string-db.org/network/511145.b1073Flagellar component of cell-proximal portion of basal-body rod; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similari [...]
flgC protein networkhttps://string-db.org/network/511145.b1074Flagellar biosynthesis, cell-proximal portion of basal-body rod; Protein involved in flagellum assembly and taxis.
flgD protein networkhttps://string-db.org/network/511145.b1075Flagellar hook assembly protein; Required for flagellar hook formation. May act as a scaffolding protein.
flgE protein networkhttps://string-db.org/network/511145.b1076Flagellar biosynthesis, hook protein; Protein involved in flagellum assembly and taxis.
flgF protein networkhttps://string-db.org/network/511145.b1077Flagellar biosynthesis, cell-proximal portion of basal-body rod; Protein involved in flagellum assembly and taxis.
flgG protein networkhttps://string-db.org/network/511145.b1078Flagellar biosynthesis, cell-distal portion of basal-body rod; Protein involved in flagellum assembly and taxis.
flgH protein networkhttps://string-db.org/network/511145.b1079Flagellar protein of basal-body outer-membrane L ring; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
flgI protein networkhttps://string-db.org/network/511145.b1080Putative flagellar basal body protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
flgJ protein networkhttps://string-db.org/network/511145.b1081Flagellar rod assembly protein and murein hydrolase; Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; In the C-termin [...]
flgK protein networkhttps://string-db.org/network/511145.b1082Flagellar biosynthesis, hook-filament junction protein 1; Protein involved in flagellum assembly, protein folding and taxis; Belongs to the flagella basal body rod proteins family.
flgL protein networkhttps://string-db.org/network/511145.b1083Flagellar biosynthesis; hook-filament junction protein; Protein involved in flagellum assembly, protein folding and taxis.
rne protein networkhttps://string-db.org/network/511145.b1084Endoribonuclease; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradati [...]
yceQ protein networkhttps://string-db.org/network/511145.b1085Uncharacterized protein.
rluC protein networkhttps://string-db.org/network/511145.b108623S rRNA pseudouridine(955,2504,2580) synthase; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA.
yceF protein networkhttps://string-db.org/network/511145.b1087m(7)GTP pyrophosphatase; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modif [...]
yceD protein networkhttps://string-db.org/network/511145.b1088DUF177 family protein; Plays a role in synthesis, processing and/or stability of 23S rRNA.
rpmF protein networkhttps://string-db.org/network/511145.b108950S ribosomal subunit protein L32; Protein involved in structural constituent of ribosome and translation.
plsX protein networkhttps://string-db.org/network/511145.b1090Putative phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl don [...]
fabH protein networkhttps://string-db.org/network/511145.b10913-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first [...]
fabD protein networkhttps://string-db.org/network/511145.b1092malonyl-CoA-[acyl-carrier-protein] transacylase; Belongs to the FabD family.
fabG protein networkhttps://string-db.org/network/511145.b10933-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cy [...]
acpP protein networkhttps://string-db.org/network/511145.b1094Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
fabF protein networkhttps://string-db.org/network/511145.b10953-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for [...]
pabC protein networkhttps://string-db.org/network/511145.b10964-amino-4-deoxychorismate lyase component of para-aminobenzoate synthase multienzyme complex; Involved in the biosynthesis of p-aminobenzoate (PABA), a precursor of tetrahydrofolate. Converts 4-a [...]
yceG protein networkhttps://string-db.org/network/511145.b1097Septation protein, ampicillin sensitivity; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglyco [...]
tmk protein networkhttps://string-db.org/network/511145.b1098Thymidylate kinase; Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at [...]
holB protein networkhttps://string-db.org/network/511145.b1099DNA polymerase III, delta prime subunit; Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation com [...]
ycfH protein networkhttps://string-db.org/network/511145.b1100Putative DNase; Has D-tyrosyl-tRNA deacylase activity in vitro.
ptsG protein networkhttps://string-db.org/network/511145.b1101Fused glucose-specific PTS enzymes: IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catal [...]
fhuE protein networkhttps://string-db.org/network/511145.b1102Ferric-rhodotorulic acid outer membrane transporter; Required for the uptake of Fe(3+) via coprogen, ferrioxamine B, and rhodotorulic acid.
hinT protein networkhttps://string-db.org/network/511145.b1103Purine nucleoside phosphoramidase, dadA activator protein; Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate [...]
ycfL protein networkhttps://string-db.org/network/511145.b1104Uncharacterized protein.
lpoB protein networkhttps://string-db.org/network/511145.b1105OM lipoprotein stimulator of MrcB transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Stimulates transpeptidase and t [...]
thiK protein networkhttps://string-db.org/network/511145.b1106Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
nagZ protein networkhttps://string-db.org/network/511145.b1107Beta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving r [...]
ycfP protein networkhttps://string-db.org/network/511145.b1108Putative UPF0227 family esterase.
ndh protein networkhttps://string-db.org/network/511145.b1109Respiratory NADH dehydrogenase 2/cupric reductase; Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not [...]
ycfJ protein networkhttps://string-db.org/network/511145.b1110Uncharacterized protein.
ycfQ protein networkhttps://string-db.org/network/511145.b1111Repressor for bhsA(ycfR); Represses expression of BhsA/ComC by binding to its promoter region in the absence of copper.
bhsA protein networkhttps://string-db.org/network/511145.b1112Biofilm, cell surface and signaling protein; Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation [...]
ldtC protein networkhttps://string-db.org/network/511145.b1113L,D-transpeptidase linking Lpp to murein; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via [...]
mfd protein networkhttps://string-db.org/network/511145.b1114Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated tr [...]
ycfT protein networkhttps://string-db.org/network/511145.b1115Inner membrane protein.
lolC protein networkhttps://string-db.org/network/511145.b1116Lipoprotein-releasing system transmembrane protein; Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner memb [...]
lolD protein networkhttps://string-db.org/network/511145.b1117Outer membrane-specific lipoprotein transporter subunit; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner me [...]
lolE protein networkhttps://string-db.org/network/511145.b1118Lipoprotein-releasing system transmembrane protein; Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner memb [...]
nagK protein networkhttps://string-db.org/network/511145.b1119N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Has also low level glucokinase activity in [...]
cobB protein networkhttps://string-db.org/network/511145.b1120Deacetylase of acs and cheY, chemotaxis regulator; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activi [...]
ycfZ protein networkhttps://string-db.org/network/511145.b1121Inner membrane protein.
ymfA protein networkhttps://string-db.org/network/511145.b1122DUF3592 family inner membrane protein.
potD protein networkhttps://string-db.org/network/511145.b1123Spermidine/putrescine ABC transporter periplasmic binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein; [...]
potC protein networkhttps://string-db.org/network/511145.b1124Spermidine/putrescine ABC transporter permease; Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine; Belongs to the binding-protein-dependent tran [...]
potB protein networkhttps://string-db.org/network/511145.b1125Spermidine/putrescine ABC transporter permease; Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine; Belongs to the binding-protein-dependent tran [...]
potA protein networkhttps://string-db.org/network/511145.b1126Spermidine/putrescine ABC transporter ATPase; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. Belong [...]
pepT protein networkhttps://string-db.org/network/511145.b1127Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.
roxA protein networkhttps://string-db.org/network/511145.b112850S ribosomal protein L16 arginine hydroxylase; Growth-regulating oxygenase that catalyzes the hydroxylation of 50S ribosomal protein L16 on 'Arg-81'.
phoQ protein networkhttps://string-db.org/network/511145.b1129Sensory histidine kinase in two-component regulatory system with PhoP; Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of [...]
phoP protein networkhttps://string-db.org/network/511145.b1130Response regulator in two-component regulatory system with PhoQ; Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid [...]
purB protein networkhttps://string-db.org/network/511145.b1131Adenylosuccinate lyase; Protein involved in purine nucleotide biosynthetic process; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
hflD protein networkhttps://string-db.org/network/511145.b1132Putative lysogenization regulator; Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membr [...]
mnmA protein networkhttps://string-db.org/network/511145.b1133tRNA(Gln,Lys,Glu) U34 2-thiouridylase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first ste [...]
nudJ protein networkhttps://string-db.org/network/511145.b1134Bifunctional thiamine pyrimidine pyrophosphate hydrolase and thiamine pyrophosphate hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4- [...]
rluE protein networkhttps://string-db.org/network/511145.b113523S rRNA pseudouridine(2457) synthase; Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.
icd protein networkhttps://string-db.org/network/511145.b1136Isocitrate dehydrogenase, specific for NADP+; Protein involved in tricarboxylic acid cycle and anaerobic respiration; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
ymfD protein networkhttps://string-db.org/network/511145.b1137E14 prophage; putative SAM-dependent methyltransferase.
ymfE protein networkhttps://string-db.org/network/511145.b1138E14 prophage; putative inner membrane protein.
lit protein networkhttps://string-db.org/network/511145.b1139T4 phage exclusion protein; Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4; general translation inhibition occurs when this late gene [...]
intE protein networkhttps://string-db.org/network/511145.b1140E14 prophage; Integrase from the cryptic lambdoic prophage e14. Integrase is necessary for integration of the phage into the host genome by site- specific recombination. In conjunction with excis [...]
xisE protein networkhttps://string-db.org/network/511145.b1141E14 prophage; putative excisionase; To lambdoid phages excisionases.
ymfI protein networkhttps://string-db.org/network/511145.b1143E14 prophage; uncharacterized protein.
ymfJ protein networkhttps://string-db.org/network/511145.b1144E14 prophage; uncharacterized protein.
cohE protein networkhttps://string-db.org/network/511145.b1145E14 prophage; repressor protein phage e14.
croE protein networkhttps://string-db.org/network/511145.b1146E14 prophage; putative DNA-binding transcriptional regulator.
ymfL protein networkhttps://string-db.org/network/511145.b1147E14 prophage; putative DNA-binding transcriptional regulator.
ymfM protein networkhttps://string-db.org/network/511145.b1148E14 prophage; uncharacterized protein.
ymfR protein networkhttps://string-db.org/network/511145.b1150Uncharacterized protein YmfR; Pseudogene, phage terminase protein A family, e14 prophage;Phage or Prophage Related.
ymfQ protein networkhttps://string-db.org/network/511145.b1153Uncharacterized protein YmfQ; Pseudogene, e14 prophage;Phage or Prophage Related; To phage Mu protein gp48 and H.influenzae HI_1521.
stfP protein networkhttps://string-db.org/network/511145.b1154E14 prophage; uncharacterized protein; To E.coli YfdL and M.jannaschii MJ0347.
tfaP protein networkhttps://string-db.org/network/511145.b1155E14 prophage; uncharacterized protein; To E.coli YfdK.
tfaE protein networkhttps://string-db.org/network/511145.b1156E14 prophage; putative tail fiber assembly protein.
pinE protein networkhttps://string-db.org/network/511145.b1158Serine recombinase PinE; This protein catalyzes the inversion of an 1800-bp E.coli DNA fragment, the P region, which can exist in either orientation. The function of the inversion is not yet clea [...]
mcrA protein networkhttps://string-db.org/network/511145.b1159Putative 5-methylcytosine/5-hydroxymethylcytosine-specific restriction nuclease; Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence C(me)CGG.
iraM protein networkhttps://string-db.org/network/511145.b1160Anti-adapter protein IraM; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation. May also be involve [...]
ycgX protein networkhttps://string-db.org/network/511145.b1161DUF1398 family protein; To E.coli YbcV and YdfO.
bluR protein networkhttps://string-db.org/network/511145.b1162Repressor of blue light-responsive genes; Controls the expression of several small proteins that may play a role in biofilm maturation. Binds to and represses the operator of the ycgZ-ymgA-ariR-y [...]
bluF protein networkhttps://string-db.org/network/511145.b1163Anti-repressor for YcgE, blue light-responsive; Binds to and releases the BluR repressor from its bound DNA target in a blue light-dependent (470 nm) fashion. A shift to low temperature also trig [...]
ycgZ protein networkhttps://string-db.org/network/511145.b1164RcsB connector protein for regulation of biofilm and acid-resistance; Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-compo [...]
ymgA protein networkhttps://string-db.org/network/511145.b1165RcsB connector protein for regulation of biofilm; Probably a connector protein for RcsB/C regulation of biofilm formation, providing additional signal input into the two-component signaling pathw [...]
ariR protein networkhttps://string-db.org/network/511145.b1166RcsB connector protein for regulation of biofilm and acid-resistance; Probably a connector protein for RcsB/C regulation of biofilm and acid-resistance, providing additional signal input into the [...]
ymgC protein networkhttps://string-db.org/network/511145.b1167Blue light, low temperature and stress induced protein.
ycgG protein networkhttps://string-db.org/network/511145.b1168Putative membrane-anchored cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
ymgD protein networkhttps://string-db.org/network/511145.b1171Uncharacterized protein YmgD; Pseudogene; putative ATP-binding component of a transport system.
ymgG protein networkhttps://string-db.org/network/511145.b1172UPF0757 family protein.
minE protein networkhttps://string-db.org/network/511145.b1174Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures c [...]
minD protein networkhttps://string-db.org/network/511145.b1175Inhibitor of FtsZ ring polymerization; ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocki [...]
minC protein networkhttps://string-db.org/network/511145.b1176Inhibitor of FtsZ ring polymerization; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments th [...]
ycgJ protein networkhttps://string-db.org/network/511145.b1177Uncharacterized protein.
pliG protein networkhttps://string-db.org/network/511145.b1178Periplasmic inhibitor of g-type lysozyme; Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium.
ycgL protein networkhttps://string-db.org/network/511145.b1179UPF0745 family protein.
ycgM protein networkhttps://string-db.org/network/511145.b1180Putative isomerase; Belongs to the FAH family.
ycgN protein networkhttps://string-db.org/network/511145.b1181UPF0153 family cysteine cluster protein; Belongs to the UPF0260 family.
hlyE protein networkhttps://string-db.org/network/511145.b1182Hemolysin E; Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
umuD protein networkhttps://string-db.org/network/511145.b1183Translesion error-prone DNA polymerase V subunit; Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair. Essential for induced (or S [...]
umuC protein networkhttps://string-db.org/network/511145.b1184Translesion error-prone DNA polymerase V subunit; Involved in UV protection and mutation. Poorly processive, error-prone DNA polymerase involved in translesion repair. Essential for induced (or S [...]
dsbB protein networkhttps://string-db.org/network/511145.b1185Oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by oxidizing the Dsb [...]
nhaB protein networkhttps://string-db.org/network/511145.b1186Sodium:proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Catalyzes the exchange of 3 H(+) per 2 Na(+). Has a high affinity for sodium, but can also t [...]
fadR protein networkhttps://string-db.org/network/511145.b1187Fatty acid metabolism regulon transcriptional regulator; Multifunctional regulator of fatty acid metabolism. Represses transcription of at least eight genes required for fatty acid transport and [...]
ycgB protein networkhttps://string-db.org/network/511145.b1188SpoVR family stationary phase protein; To B.subtilis SpoVR.
dadA protein networkhttps://string-db.org/network/511145.b1189D-amino acid dehydrogenase; Catalyzes the oxidative deamination of D-amino acids. Has broad substrate specificity; is mostly active on D-alanine, and to a lesser extent, on several other D-amino [...]
dadX protein networkhttps://string-db.org/network/511145.b1190Alanine racemase, catabolic, PLP-binding; Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by DadA.
cvrA protein networkhttps://string-db.org/network/511145.b1191Putative cation/proton antiporter; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels (By simil [...]
ldcA protein networkhttps://string-db.org/network/511145.b1192Murein tetrapeptide carboxypeptidase; Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso-Dap-D-Ala. To a lesser extent, can also cl [...]
emtA protein networkhttps://string-db.org/network/511145.b1193Lytic murein endotransglycosylase E; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of mor [...]
ycgR protein networkhttps://string-db.org/network/511145.b1194Flagellar velocity braking protein, c-di-GMP-regulated; Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. When bound [...]
ymgE protein networkhttps://string-db.org/network/511145.b1195UPF0410 family putative inner membrane protein; Transglycosylase asociated protein.
ycgY protein networkhttps://string-db.org/network/511145.b1196Uncharacterized protein.
treA protein networkhttps://string-db.org/network/511145.b1197Periplasmic trehalase; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransfera [...]
dhaM protein networkhttps://string-db.org/network/511145.b1198Putative dihydroxyacetone-specific PTS enzymes: HPr, EI components; Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylat [...]
dhaL protein networkhttps://string-db.org/network/511145.b1199Dihydroxyacetone kinase, C-terminal domain; ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyaceton [...]
dhaK protein networkhttps://string-db.org/network/511145.b1200Dihydroxyacetone kinase, PTS-dependent, dihydroxyacetone-binding subunit; Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)- [...]
dhaR protein networkhttps://string-db.org/network/511145.b1201dhaKLM operon transcription activator; Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own expression.
ycgV protein networkhttps://string-db.org/network/511145.b1202Putative adhesion and penetration protein.
ychF protein networkhttps://string-db.org/network/511145.b1203Catalase inhibitor protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. Does not hydrolyze GTP; Belongs to the TRAFAC class OBG-Hf [...]
pth protein networkhttps://string-db.org/network/511145.b1204peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Involved in lambda inhibition of host protein synthesis. [...]
ychH protein networkhttps://string-db.org/network/511145.b1205DUF2583 family putative inner membrane protein.
dauA protein networkhttps://string-db.org/network/511145.b1206C4-dicarboxylic acid transporter; Responsible for the aerobic transport of succinate from the periplasm to the cytoplasm at acidic pH. Can transport other C4- dicarboxylic acids such as aspartate [...]
prs protein networkhttps://string-db.org/network/511145.b1207Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1- [...]
ispE protein networkhttps://string-db.org/network/511145.b12084-diphosphocytidyl-2-C-methylerythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at [...]
lolB protein networkhttps://string-db.org/network/511145.b1209Lipoprotein localization factor; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein. Essential for E.coli viability; Belo [...]
hemA protein networkhttps://string-db.org/network/511145.b1210Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). In the absence of NADPH, exhibits substrate esterase activity, leading to [...]
prfA protein networkhttps://string-db.org/network/511145.b1211Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
prmC protein networkhttps://string-db.org/network/511145.b1212RF-1 and RF-2 N5-glutamine methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, [...]
ychQ protein networkhttps://string-db.org/network/511145.b1213SIRB family inner membrane protein; Protein involved in regulation of transcription, DNA-dependent.
ychA protein networkhttps://string-db.org/network/511145.b1214Transglutaminase-like TPR-repeat protein; Protein involved in regulation of transcription, DNA-dependent; Belongs to the UPF0162 family.
kdsA protein networkhttps://string-db.org/network/511145.b12153-deoxy-D-manno-octulosonate 8-phosphate synthase; Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.
chaA protein networkhttps://string-db.org/network/511145.b1216Calcium/sodium:proton antiporter; Sodium exporter that functions mainly at alkaline pH. Can also function as a potassium/proton and calcium/proton antiporter at alkaline pH. Does not play a major [...]
chaB protein networkhttps://string-db.org/network/511145.b1217Cation transport regulator; Might be a regulator of the sodium-potassium/proton antiporter ChaA; Belongs to the ChaB family.
chaC protein networkhttps://string-db.org/network/511145.b1218Cation transport regulator; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
ychN protein networkhttps://string-db.org/network/511145.b1219Putative sulfur relay protein.
ychO protein networkhttps://string-db.org/network/511145.b1220Conserved protein, invasin-like.
narL protein networkhttps://string-db.org/network/511145.b1221Response regulator in two-component regulatory system with NarX; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represse [...]
narX protein networkhttps://string-db.org/network/511145.b1222Sensory histidine kinase in two-component regulatory system with NarL; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate/n [...]
narK protein networkhttps://string-db.org/network/511145.b1223Nitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. Functions as a nitrate/nitrite exchanger, and protons are probably not co [...]
narG protein networkhttps://string-db.org/network/511145.b1224Nitrate reductase 1, alpha subunit; The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The alpha chain is the actual site of nitrat [...]
narH protein networkhttps://string-db.org/network/511145.b1225Nitrate reductase 1, beta (Fe-S) subunit; The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The beta chain is an electron transfer [...]
narJ protein networkhttps://string-db.org/network/511145.b1226Molybdenum-cofactor-assembly chaperone delta subunit of nitrate reductase 1; Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitra [...]
narI protein networkhttps://string-db.org/network/511145.b1227Nitrate reductase 1, gamma (cytochrome b(NR)) subunit; The nitrate reductase enzyme complex allows E.coli to use nitrate as an electron acceptor during anaerobic growth. The gamma chain is a memb [...]
tpr protein networkhttps://string-db.org/network/511145.b1229A protamine-like protein.
purU protein networkhttps://string-db.org/network/511145.b1232Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). Provides the major source of formate for the PurT-depen [...]
ychJ protein networkhttps://string-db.org/network/511145.b1233UPF0225 family protein.
rssA protein networkhttps://string-db.org/network/511145.b1234Putative patatin-like family phospholipase; Belongs to the NTE family.
rssB protein networkhttps://string-db.org/network/511145.b1235PcnB-degradosome interaction factor; Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the Cl [...]
galU protein networkhttps://string-db.org/network/511145.b1236Glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family.
hns protein networkhttps://string-db.org/network/511145.b1237Global DNA-binding transcriptional dual regulator H-NS; A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compacti [...]
tdk protein networkhttps://string-db.org/network/511145.b1238Thymidine kinase/deoxyuridine kinase; Phosphorylates both thymidine and deoxyuridine.
adhE protein networkhttps://string-db.org/network/511145.b1241Acetaldehyde dehydrogenase [acetylating]; This enzyme has three activities: ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase acti [...]
ychE protein networkhttps://string-db.org/network/511145.b1242UPF0056 family inner membrane protein; Putative channel protein.
oppA protein networkhttps://string-db.org/network/511145.b1243Oligopeptide ABC transporter periplasmic binding protein; This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amin [...]
oppB protein networkhttps://string-db.org/network/511145.b1244Oligopeptide ABC transporter permease; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; B [...]
oppC protein networkhttps://string-db.org/network/511145.b1245Oligopeptide ABC transporter permease; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; B [...]
oppD protein networkhttps://string-db.org/network/511145.b1246Oligopeptide ABC transporter ATPase; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system.
oppF protein networkhttps://string-db.org/network/511145.b1247Oligopeptide ABC transporter ATPase; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC [...]
yciU protein networkhttps://string-db.org/network/511145.b1248UPF0263 family protein.
clsA protein networkhttps://string-db.org/network/511145.b1249Cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
kch protein networkhttps://string-db.org/network/511145.b1250Voltage-gated potassium channel; K(+)-specific ion channel. May play a role in the defense against osmotic shock.
yciI protein networkhttps://string-db.org/network/511145.b1251Putative DGPF domain-containing enzyme.
tonB protein networkhttps://string-db.org/network/511145.b1252Membrane spanning protein in TonB-ExbB-ExbD transport complex; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmi [...]
yciA protein networkhttps://string-db.org/network/511145.b1253acyl-CoA esterase; Catalyzes the hydrolysis of the thioester bond in palmitoyl- CoA and malonyl-CoA.
yciB protein networkhttps://string-db.org/network/511145.b1254IspA family inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family.
yciC protein networkhttps://string-db.org/network/511145.b1255UPF0259 family inner membrane protein.
ompW protein networkhttps://string-db.org/network/511145.b1256Outer membrane protein W; Acts as a receptor for colicin S4.
yciE protein networkhttps://string-db.org/network/511145.b1257Putative rubrerythrin/ferritin-like metal-binding protein.
yciF protein networkhttps://string-db.org/network/511145.b1258Putative structural proteins.
yciG protein networkhttps://string-db.org/network/511145.b1259KGG family protein; Belongs to the con-10 family.
trpA protein networkhttps://string-db.org/network/511145.b1260Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family.
trpB protein networkhttps://string-db.org/network/511145.b1261Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpB family.
trpC protein networkhttps://string-db.org/network/511145.b1262Indole-3-glycerolphosphate synthetase and N-(5-phosphoribosyl)anthranilate isomerase; Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reactio [...]
trpD protein networkhttps://string-db.org/network/511145.b1263Anthranilate phosphoribosyltransferase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the f [...]
trpE protein networkhttps://string-db.org/network/511145.b1264Component I of anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the fir [...]
trpL protein networkhttps://string-db.org/network/511145.b1265Trp operon leader peptide; This protein is involved in control of the biosynthesis of tryptophan.
yciV protein networkhttps://string-db.org/network/511145.b1266PHP domain protein; Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of [...]
yciO protein networkhttps://string-db.org/network/511145.b1267Putative RNA binding protein; Belongs to the SUA5 family.
yciQ protein networkhttps://string-db.org/network/511145.b1268Enhancer of membrane protein expression; putative inner membrane protein.
rluB protein networkhttps://string-db.org/network/511145.b126923S rRNA pseudouridine(2605) synthase; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA.
btuR protein networkhttps://string-db.org/network/511145.b1270cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a vari [...]
yciK protein networkhttps://string-db.org/network/511145.b1271Putative EmrKY-TolC system oxoacyl-(acyl carrier protein) reductase; Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
sohB protein networkhttps://string-db.org/network/511145.b1272Inner membrane protein, S49 peptidase family protein; Multicopy suppressor of the HtrA (DegP) null phenotype. It is possibly a protease, not essential for bacterial viability; Belongs to the pept [...]
yciN protein networkhttps://string-db.org/network/511145.b1273DUF2498 protein YciN.
topA protein networkhttps://string-db.org/network/511145.b1274DNA topoisomerase I, omega subunit; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining [...]
cysB protein networkhttps://string-db.org/network/511145.b1275N-acetylserine-responsive cysteine regulon transcriptional activator; This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the [...]
acnA protein networkhttps://string-db.org/network/511145.b1276Aconitate hydratase 1; Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA- binding regulatory protein which plays a role as [...]
ribA protein networkhttps://string-db.org/network/511145.b1277GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
pgpB protein networkhttps://string-db.org/network/511145.b1278Phosphatidylglycerophosphatase B; Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Al [...]
yciS protein networkhttps://string-db.org/network/511145.b1279DUF1049 family inner membrane protein, function unknown; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
yciM protein networkhttps://string-db.org/network/511145.b1280LPS regulatory protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH to [...]
pyrF protein networkhttps://string-db.org/network/511145.b1281Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
yciH protein networkhttps://string-db.org/network/511145.b1282Initiation factor function partial mimic, SUI1 family; Belongs to the SUI1 family.
osmB protein networkhttps://string-db.org/network/511145.b1283Osmotically and stress inducible lipoprotein; Provides resistance to osmotic stress. May be important for stationary-phase survival.
yciT protein networkhttps://string-db.org/network/511145.b1284Putative DEOR-type transcriptional regulator; Protein involved in transcription repressor activity and transcription.
gmr protein networkhttps://string-db.org/network/511145.b1285cyclic-di-GMP phosphodiesterase; Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP controll [...]
rnb protein networkhttps://string-db.org/network/511145.b1286Ribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction. RNases 2 and R (rnr) contribute to rRNA degradation during st [...]
yciW protein networkhttps://string-db.org/network/511145.b1287Putative oxidoreductase.
fabI protein networkhttps://string-db.org/network/511145.b1288Enoyl-[acyl-carrier-protein] reductase, NADH-dependent; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Invol [...]
ycjD protein networkhttps://string-db.org/network/511145.b1289DUF559 family endonuclease-related protein; To H.influenzae HI_1162 and to HI_0925.
sapF protein networkhttps://string-db.org/network/511145.b1290Antimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Does not stimulate K(+) uptake ability of [...]
sapD protein networkhttps://string-db.org/network/511145.b1291Antimicrobial peptide ABC transporter ATPase; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K(+)-uptake proteins TrkG and [...]
sapC protein networkhttps://string-db.org/network/511145.b1292Antimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides.
sapB protein networkhttps://string-db.org/network/511145.b1293Antimicrobial peptide transport ABC transporter permease; Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides.
sapA protein networkhttps://string-db.org/network/511145.b1294Antimicrobial peptide transport ABC transporter periplasmic binding protein; Not part of a putrescine export system. Very similar to a S.typhimurium protein implicated in antimicrobial peptide re [...]
ymjA protein networkhttps://string-db.org/network/511145.b1295DUF2543 family protein.
puuP protein networkhttps://string-db.org/network/511145.b1296Putrescine importer; Involved in the uptake of putrescine. Belongs to the amino acid-polyamine-organocation (APC) superfamily.
puuA protein networkhttps://string-db.org/network/511145.b1297Glutamate--putrescine ligase; Involved in the breakdown of putrescine via the biosynthesis of gamma-L-glutamylputrescine. It is able to use several diamines, spermidine and spermine. Absolutely e [...]
puuD protein networkhttps://string-db.org/network/511145.b1298Gamma-glutamyl-gamma-aminobutyrate hydrolase; Involved in the breakdown of putrescine via hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma-aminobutyrate.
puuR protein networkhttps://string-db.org/network/511145.b1299Repressor for the divergent puu operons, putrescine inducible; Represses puuA, puuD and puuP.
puuC protein networkhttps://string-db.org/network/511145.b1300Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Catalyzes the oxidation of 3-hydroxypropionaldehyde (3-HPA) to 3-hydroxypropionic acid (3-HP). It acts preferentially with NAD but can also [...]
puuB protein networkhttps://string-db.org/network/511145.b1301Gamma-glutamylputrescine oxidoreductase; Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine.
puuE protein networkhttps://string-db.org/network/511145.b13024-aminobutyrate aminotransferase, PLP-dependent; Catalyzes the transfer of the amino group from gamma- aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE [...]
pspF protein networkhttps://string-db.org/network/511145.b1303Psp operon transcriptional activator; Transcriptional activator for the phage shock protein (psp) operon (pspABCDE) and pspG gene.
pspA protein networkhttps://string-db.org/network/511145.b1304Regulatory protein for phage-shock-protein operon; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited co [...]
pspB protein networkhttps://string-db.org/network/511145.b1305Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. Ps [...]
pspC protein networkhttps://string-db.org/network/511145.b1306Psp operon transcription co-activator; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited conditions. Ps [...]
pspD protein networkhttps://string-db.org/network/511145.b1307Peripheral inner membrane phage-shock protein; The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited condit [...]
pspE protein networkhttps://string-db.org/network/511145.b1308Thiosulfate:cyanide sulfurtransferase (rhodanese); The phage shock protein (psp) operon (pspABCDE) may play a significant role in the competition for survival under nutrient- or energy-limited co [...]
ycjM protein networkhttps://string-db.org/network/511145.b1309Alpha amylase catalytic domain family protein; Catalyzes the reversible phosphorolysis of glucosylglycerate into alpha-D-glucose 1-phosphate (Glc1P) and D-glycerate (also called (R)-glycerate). M [...]
ycjN protein networkhttps://string-db.org/network/511145.b1310Putative ABC sugar transporter periplasmic binding protein; Probably part of the binding-protein-dependent transport system YcjNOP; Belongs to the bacterial solute-binding protein 1 family.
ycjO protein networkhttps://string-db.org/network/511145.b1311Putative sugar ABC transporter permease; Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane; B [...]
ycjP protein networkhttps://string-db.org/network/511145.b1312Putative sugar ABC transporter permease; Probably part of the binding-protein-dependent transport system YcjNOP. Probably responsible for the translocation of the substrate across the membrane; B [...]
ycjQ protein networkhttps://string-db.org/network/511145.b1313Putative Zn-dependent NAD(P)-binding oxidoreductase; Catalyzes the NAD(+)-dependent oxidation of the hydroxyl group at C3 of D-gulosides leading to 3-dehydro-D-gulosides. Probably functions in a [...]
ycjR protein networkhttps://string-db.org/network/511145.b1314Putative TIM alpha/beta barrel enzyme; Catalyzes the epimerization at C4 of 3-dehydro-D-gulosides leading to 3-dehydro-D-glucosides. Probably functions in a metabolic pathway that transforms D-gu [...]
ycjS protein networkhttps://string-db.org/network/511145.b1315Putative NADH-binding oxidoreductase; Catalyzes the NADH-dependent reduction of the oxo group at C3 of 3-dehydro-D-glucosides leading to D-glucosides. Probably functions in a metabolic pathway th [...]
ycjT protein networkhttps://string-db.org/network/511145.b1316Putative family 65 glycosyl hydrolase; In vitro catalyzes the phosphorolysis of D-kojibiose into beta-D-glucose 1-phosphate and D-glucose. No other disaccharides tested substitute for D-kojibiose [...]
ycjU protein networkhttps://string-db.org/network/511145.b1317Beta-phosphoglucomutase; Catalyzes the conversion of beta D-glucose 1-phosphate (G1P) to D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6- (bis)phosphate (beta-G16P) as an intermediate (P [...]
ompG protein networkhttps://string-db.org/network/511145.b1319Outer membrane porin G; Forms channels functionally larger than those of classical porins.
ycjW protein networkhttps://string-db.org/network/511145.b1320Putative LACI-type transcriptional regulator; Protein involved in transcription repressor activity and transcription.
ycjX protein networkhttps://string-db.org/network/511145.b1321DUF463 family protein, puatative P-loop NTPase; Putative EC 2.1 enzymes; To H.influenzae HI_1637.
ycjF protein networkhttps://string-db.org/network/511145.b1322UPF0283 family inner membrane protein.
tyrR protein networkhttps://string-db.org/network/511145.b1323Aromatic amino acid biosynthesis and transport regulon transcriptional regulator; Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expressio [...]
tpx protein networkhttps://string-db.org/network/511145.b1324Lipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell pr [...]
ycjG protein networkhttps://string-db.org/network/511145.b1325L-Ala-D/L-Glu epimerase; Catalyzes the epimerization of L-Ala-D-Glu to L-Ala-L-Glu and has a role in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. Is also able to cata [...]
mpaA protein networkhttps://string-db.org/network/511145.b1326Murein peptide amidase A; Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl- [...]
ycjY protein networkhttps://string-db.org/network/511145.b1327Uncharacterized protein YcjY; Pseudogene fragment, MhpC family.
pgrR protein networkhttps://string-db.org/network/511145.b1328Murein peptide degradation regulator; Regulates the expression of genes involved in peptidoglycan (PG) degradation. Could play a role in switch control between recycling and degradation of PG pep [...]
mppA protein networkhttps://string-db.org/network/511145.b1329Murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit; Essential for the uptake of the murein peptide L-alanyl- gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha [...]
ynaI protein networkhttps://string-db.org/network/511145.b1330Mechanosensitive channel protein, very small conductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Belongs to the MscS (TC 1.A.23) family [...]
insH1-4 protein networkhttps://string-db.org/network/511145.b1331IS5 transposase and trans-activator.
ynaJ protein networkhttps://string-db.org/network/511145.b1332DUF2534 family putative inner membrane protein.
uspE protein networkhttps://string-db.org/network/511145.b1333Stress-induced protein; Required for resistance to DNA-damaging agents.
fnr protein networkhttps://string-db.org/network/511145.b1334Oxygen-sensing anaerobic growth regulon transcriptional regulator FNR; Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the [...]
ogt protein networkhttps://string-db.org/network/511145.b1335O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs [...]
abgT protein networkhttps://string-db.org/network/511145.b1336P-aminobenzoyl-glutamate transporter; Essential for aminobenzoyl-glutamate utilization. It catalyzes the concentration-dependent uptake of p-aminobenzoyl- glutamate (PABA-GLU) into the cell and a [...]
abgB protein networkhttps://string-db.org/network/511145.b1337P-aminobenzoyl-glutamate hydrolase, B subunit; Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU [...]
abgA protein networkhttps://string-db.org/network/511145.b1338P-aminobenzoyl-glutamate hydrolase, A subunit; Component of the p-aminobenzoyl-glutamate hydrolase multicomponent enzyme system which catalyzes the cleavage of p- aminobenzoyl-glutamate (PABA-GLU [...]
abgR protein networkhttps://string-db.org/network/511145.b1339Putative DNA-binding transcriptional regulator of abgABT operon; Could be the regulator of the abg operon; Belongs to the LysR transcriptional regulatory family.
smrA protein networkhttps://string-db.org/network/511145.b1340DNA endonuclease; Has DNA endonuclease activity. Binds DNA.
ydaM protein networkhttps://string-db.org/network/511145.b1341Diguanylate cyclase, csgD regulator; Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two cyclic-di-GMP (c-di-GMP) control modules, in which c-di-GMP cont [...]
ydaN protein networkhttps://string-db.org/network/511145.b1342Putative Zn(II) transporter; Mediates efflux of zinc ions.
dbpA protein networkhttps://string-db.org/network/511145.b1343ATP-dependent RNA helicase, specific for 23S rRNA; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRN [...]
ttcA protein networkhttps://string-db.org/network/511145.b1344tRNA s(2)C32 thioltransferase, iron sulfur cluster protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are pro [...]
intR protein networkhttps://string-db.org/network/511145.b1345Rac prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of [...]
ydaQ protein networkhttps://string-db.org/network/511145.b1346Rac prophage; Putative lambdoid prophage Rac excisionase.
ydaC protein networkhttps://string-db.org/network/511145.b1347DUF1187 family protein, Rac prophage; Helps to maintain the integrity of the chromosome by lowering the steady-state level of double strand breaks. This region of DNA acts as an antitoxin to toxi [...]
ralR protein networkhttps://string-db.org/network/511145.b1348Rac prophage; Toxic component of a type I toxin-antitoxin (TA) system. Upon overexpression inhibits growth and reduces colony-forming units in both the presence and absence of the Rac prophage, c [...]
recT protein networkhttps://string-db.org/network/511145.b1349Rac prophage; Binds to single-stranded DNA and also promotes the renaturation of complementary single-stranded DNA. Function in recombination. Has a function similar to that of lambda RedB.
recE protein networkhttps://string-db.org/network/511145.b1350Rac prophage; Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'-phosphomononucleotides. [...]
racC protein networkhttps://string-db.org/network/511145.b1351RacC protein.
kilR protein networkhttps://string-db.org/network/511145.b1352Killing protein, Rac prophage; Causes inhibition of cell division. At high levels of expression, can also abolish the rod shape of the cells. Division inhibition by KilR can be relieved by overex [...]
sieB protein networkhttps://string-db.org/network/511145.b1353Phage superinfection exclusion protein.
ydaG protein networkhttps://string-db.org/network/511145.b1355Rac prophage; uncharacterized protein.
racR protein networkhttps://string-db.org/network/511145.b1356Rac prophage; Repressor protein for rac prophage.
ydaS protein networkhttps://string-db.org/network/511145.b1357Rac prophage; putative DNA-binding transcriptional regulator.
ydaT protein networkhttps://string-db.org/network/511145.b1358Rac prophage; uncharacterized protein.
ydaU protein networkhttps://string-db.org/network/511145.b1359Rac prophage; conserved protein.
ydaV protein networkhttps://string-db.org/network/511145.b1360Rac prophage; Putative DNA replication factor.
trkG protein networkhttps://string-db.org/network/511145.b1363Rac prophage; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for maximal transport activity, low activity is seen in its ab [...]
ynaK protein networkhttps://string-db.org/network/511145.b1365Rac prophage; conserved protein.
insH1-5 protein networkhttps://string-db.org/network/511145.b1370Transposase InsH for insertion sequence element IS5Y; Involved in the transposition of the insertion sequence IS5.
stfR protein networkhttps://string-db.org/network/511145.b1372Rac prophage; putative tail fiber protein; Belongs to the tail fiber family.
tfaR protein networkhttps://string-db.org/network/511145.b1373Rac prophage; Tail fiber assembly protein homolog from lambdoid prophage Rac; Belongs to the tfa family.
pinR protein networkhttps://string-db.org/network/511145.b1374Rac prophage; putative site-specific recombinase.
ynaE protein networkhttps://string-db.org/network/511145.b1375Cold shock protein, Rac prophage.
uspF protein networkhttps://string-db.org/network/511145.b1376Universal stress protein F; Pseudogene, prophage Rac integration site ttcA duplication;Phage or Prophage Related.
ompN protein networkhttps://string-db.org/network/511145.b1377Outer membrane pore protein N, non-specific; Forms pores that allow passive diffusion of small molecules across the outer membrane (By similarity). Non-specific porin.
pfo protein networkhttps://string-db.org/network/511145.b1378Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
hslJ protein networkhttps://string-db.org/network/511145.b1379Heat-inducible lipoprotein involved in novobiocin resistance; Heat shock protein hslJ; Protein involved in response to temperature stimulus.
ldhA protein networkhttps://string-db.org/network/511145.b1380Fermentative D-lactate dehydrogenase, NAD-dependent; Fermentative lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
ydbH protein networkhttps://string-db.org/network/511145.b1381Putative membrane-anchored protein, function unknown.
ynbE protein networkhttps://string-db.org/network/511145.b1382Lipoprotein.
ydbL protein networkhttps://string-db.org/network/511145.b1383DUF1318 family protein.
feaR protein networkhttps://string-db.org/network/511145.b1384Transcriptional activator for tynA and feaB; Positive regulator of tynA/maoA and feaB/padA, the genes for 2-phenylethylamine catabolism.
feaB protein networkhttps://string-db.org/network/511145.b1385Phenylacetaldehyde dehydrogenase; Acts almost equally well on phenylacetaldehyde, 4- hydroxyphenylacetaldehyde and 3,4-dihydroxyphenylacetaldehyde.
tynA protein networkhttps://string-db.org/network/511145.b1386Tyramine oxidase, copper-requiring; The enzyme prefers aromatic over aliphatic amines; Belongs to the copper/topaquinone oxidase family.
paaZ protein networkhttps://string-db.org/network/511145.b1387oxepin-CoA hydrolase and 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase; Catalyzes the hydrolytic ring cleavage of 2-oxepin-2(3H)- ylideneacetyl-CoA (oxepin-CoA) via the open-chain aldeh [...]
paaA protein networkhttps://string-db.org/network/511145.b1388Ring 1,2-phenylacetyl-CoA epoxidase subunit; Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA- CoA) to form 1,2-epoxy [...]
paaB protein networkhttps://string-db.org/network/511145.b1389Putative ring 1,2-phenylacetyl-CoA epoxidase subunit; Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA- CoA) to form [...]
paaC protein networkhttps://string-db.org/network/511145.b1390Ring 1,2-phenylacetyl-CoA epoxidase subunit; Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA- CoA) to form 1,2-epoxy [...]
paaD protein networkhttps://string-db.org/network/511145.b1391Ring 1,2-phenylacetyl-CoA epoxidase subunit; Possible component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA (PA-CoA) to form 1 [...]
paaE protein networkhttps://string-db.org/network/511145.b1392Ring 1,2-phenylacetyl-CoA epoxidase, NAD(P)H oxidoreductase component; Component of 1,2-phenylacetyl-CoA epoxidase multicomponent enzyme system which catalyzes the reduction of phenylacetyl-CoA ( [...]
paaF protein networkhttps://string-db.org/network/511145.b13932,3-dehydroadipyl-CoA hydratase; Catalyzes the reversible conversion of enzymatically produced 2,3-dehydroadipyl-CoA into 3-hydroxyadipyl-CoA. Belongs to the enoyl-CoA hydratase/isomerase family.
paaG protein networkhttps://string-db.org/network/511145.b13941,2-epoxyphenylacetyl-CoA isomerase, oxepin-CoA-forming; Catalyzes the reversible conversion of the epoxide to 2- oxepin-2(3H)-ylideneacetyl-CoA (oxepin-CoA).
paaH protein networkhttps://string-db.org/network/511145.b13953-hydroxyadipyl-CoA dehydrogenase, NAD+-dependent; Catalyzes the oxidation of 3-hydroxyadipyl-CoA to yield 3- oxoadipyl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
paaI protein networkhttps://string-db.org/network/511145.b1396hydroxyphenylacetyl-CoA thioesterase; Thioesterase with a preference for ring-hydroxylated phenylacetyl-CoA esters. Hydrolyzes 3,4-dihydroxyphenylacetyl-CoA, 3- hydroxyphenylacetyl-CoA and 4-hydr [...]
paaJ protein networkhttps://string-db.org/network/511145.b13973-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase; Catalyzes the thiolytic cleavage of the beta-keto C8 intermediate 3-oxo-5,6-dehydrosuberyl-CoA with CoA to yield the C6 intermediate 2,3-deh [...]
paaK protein networkhttps://string-db.org/network/511145.b1398phenylacetyl-CoA ligase; Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).
paaX protein networkhttps://string-db.org/network/511145.b1399Transcriptional repressor of phenylacetic acid degradation paa operon, phenylacetyl-CoA inducer; Negative regulator of the paaZ and paaABCDEFGHIJK catabolic operons. Binds the consensus sequence [...]
paaY protein networkhttps://string-db.org/network/511145.b1400Thioesterase required for phenylacetic acid degradation; trimeric; phenylacetate regulatory and detoxification protein; hexapeptide repeat protein.
insD1-2 protein networkhttps://string-db.org/network/511145.b1402Pseudogene, autotransporter homolog; interrupted by IS2 and IS30.
insC1-2 protein networkhttps://string-db.org/network/511145.b1403IS2 repressor TnpA.
insI1-2 protein networkhttps://string-db.org/network/511145.b1404IS30 transposase; Required for the transposition of the insertion element.
ydbC protein networkhttps://string-db.org/network/511145.b1406Putative NAD(P)-binding oxidoreductase; Catalyzes the NAD(P)H-dependent reduction of pyridoxal to pyridoxine in vitro. Is not able to reduce 4-pyridoxate, and to oxidize pyridoxine or pyridoxamin [...]
ydbD protein networkhttps://string-db.org/network/511145.b1407PF10971 family putative periplasmic methylglyoxal resistance protein; To E.coli YkiA.
ynbA protein networkhttps://string-db.org/network/511145.b1408Inner membrane protein.
ynbB protein networkhttps://string-db.org/network/511145.b1409Putative CDP-diglyceride synthase; Putative phosphatidate cytidiltransferase; Protein involved in nucleobase, nucleoside and nucleotide interconversion.
ynbC protein networkhttps://string-db.org/network/511145.b1410Putative esterase.
ynbD protein networkhttps://string-db.org/network/511145.b1411Putative phosphatase inner membrane protein; Putative enzymes; Belongs to the protein-tyrosine phosphatase family.
azoR protein networkhttps://string-db.org/network/511145.b1412NADH-azoreductase, FMN-dependent; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its ac [...]
hrpA protein networkhttps://string-db.org/network/511145.b1413Putative ATP-dependent helicase; Not yet known; Belongs to the DEAD box helicase family. DEAH subfamily.
ydcF protein networkhttps://string-db.org/network/511145.b1414DUF218 superfamily protein, SAM-binding; Binds S-adenosyl-L-methionine (AdoMet); To S.coelicolor SCO4629.
aldA protein networkhttps://string-db.org/network/511145.b1415Aldehyde dehydrogenase A, NAD-linked; Acts on lactaldehyde as well as other aldehydes.
cybB protein networkhttps://string-db.org/network/511145.b1418Cytochrome b561; B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm.
ydcA protein networkhttps://string-db.org/network/511145.b1419Putative periplasmic protein.
mokB protein networkhttps://string-db.org/network/511145.b1420Regulatory peptide; Overlapping regulatory peptide whose translation enables hokB expression.
trg protein networkhttps://string-db.org/network/511145.b1421Methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor; Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-bindi [...]
ydcI protein networkhttps://string-db.org/network/511145.b1422Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
ydcJ protein networkhttps://string-db.org/network/511145.b1423Putative metalloenzyme; To M.tuberculosis Rv3292.
opgD protein networkhttps://string-db.org/network/511145.b1424OPG biosynthetic periplasmic protein; Probably involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans (OPGs).
ydcH protein networkhttps://string-db.org/network/511145.b1426DUF465 family protein.
rimL protein networkhttps://string-db.org/network/511145.b1427ribosomal-protein-L7/L12-serine acetyltransferase; This enzyme acetylates the N-terminal serine of ribosomal protein L7/L12.
ydcK protein networkhttps://string-db.org/network/511145.b1428Uncharacterized protein; Putative enzyme; Not classified; Belongs to the transferase hexapeptide repeat family.
tehA protein networkhttps://string-db.org/network/511145.b1429Potassium-tellurite ethidium and proflavin transporter; Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By [...]
tehB protein networkhttps://string-db.org/network/511145.b1430Tellurite, selenium methyltransferase, SAM-dependent; S-adenosyl-L-methionine dependent methyltransferase that catalyzes the methylation of tellurite and is responsible for tellurite resistance w [...]
ydcL protein networkhttps://string-db.org/network/511145.b1431Lipoprotein.
insQ protein networkhttps://string-db.org/network/511145.b1432Putative transposase InsQ for insertion sequence element IS609; Required for the transposition of the insertion element. In the C-terminal section; belongs to the transposase 35 family.
ydcO protein networkhttps://string-db.org/network/511145.b1433BenE family inner membrane putative transporter; Putative membrane transport protein.
ydcN protein networkhttps://string-db.org/network/511145.b1434Putative DNA-binding transcriptional regulator; Regulates the expression of 12-16 transcription units involved in various steps of sulfur utilization. Represses expression of pfkB, fliZ, cysE, yd [...]
ydcP protein networkhttps://string-db.org/network/511145.b1435Putative peptidase; Responsible for the formation of the 5-hydroxycytidine modification at the C2501 position (ho5C2501) of 23S rRNA. May be a Fe- S protein that catalyzes ho5C2501 formation usin [...]
yncJ protein networkhttps://string-db.org/network/511145.b1436Uncharacterized protein.
hicB protein networkhttps://string-db.org/network/511145.b1438Antitoxin for the HicAB toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HicA-mediated ces [...]
ydcR protein networkhttps://string-db.org/network/511145.b1439Multi modular; putative transcriptional regulator; also putative ATP-binding component of a transport system; Protein involved in ATP-binding cassette (ABC) transporter activity and regulation of [...]
ydcS protein networkhttps://string-db.org/network/511145.b1440Putative ABC transporter periplasmic binding protein; Catalyzes the formation of short polymers of R-3- hydroxybutyrate (cPHB). Involved in natural transformation. Probably part of the ABC transp [...]
ydcT protein networkhttps://string-db.org/network/511145.b1441Putative ABC transporter ATPase; Probably part of the ABC transporter complex YdcSTUV. Probably responsible for energy coupling to the transport system.
ydcU protein networkhttps://string-db.org/network/511145.b1442Putative ABC transporter permease; Probably part of the ABC transporter complex YdcSTUV. Probably responsible for the translocation of the substrate across the membrane.
ydcV protein networkhttps://string-db.org/network/511145.b1443Putative ABC transporter permease; Involved in natural transformation. Probably part of the ABC transporter complex YdcSTUV. Probably responsible for the translocation of the substrate across the [...]
patD protein networkhttps://string-db.org/network/511145.b1444Gamma-aminobutyraldehyde dehydrogenase; Catalyzes the oxidation 4-aminobutanal (gamma- aminobutyraldehyde) to 4-aminobutanoate (gamma-aminobutyrate or GABA). This is the second step in one of two [...]
ydcX protein networkhttps://string-db.org/network/511145.b1445DUF2566 family protein; Acts as an orphan toxin which is important for maintaining cell fitness during stress related to the stringent response (decreased amino acid, purine and thymidine availab [...]
ydcY protein networkhttps://string-db.org/network/511145.b1446DUF2526 family protein.
ydcZ protein networkhttps://string-db.org/network/511145.b1447DUF606 family inner membrane protein.
mnaT protein networkhttps://string-db.org/network/511145.b1448Methionine N-acyltransferase; Acyltransferase that appears to be required for E.coli optimal growth rate and yield via the formation of N-acetylated amino acids. Catalyzes the acylation of L-meth [...]
curA protein networkhttps://string-db.org/network/511145.b1449Curcumin/dihydrocurcumin reductase, NADPH-dependent; Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to te [...]
mcbR protein networkhttps://string-db.org/network/511145.b1450Colanic acid and biofilm gene transcriptional regulator, MqsR-controlled; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic a [...]
yncD protein networkhttps://string-db.org/network/511145.b1451Putative iron outer membrane transporter; Probable receptor, TonB-dependent.
yncE protein networkhttps://string-db.org/network/511145.b1452ATP-binding protein, periplasmic, function unknown; Putative receptor.
ansP protein networkhttps://string-db.org/network/511145.b1453L-asparagine permease; Protein involved in asparagine biosynthetic process.
yncG protein networkhttps://string-db.org/network/511145.b1454Glutathione S-transferase homolog; Belongs to the GST superfamily. Beta family.
yncH protein networkhttps://string-db.org/network/511145.b1455IPR020099 family protein.
ydcD protein networkhttps://string-db.org/network/511145.b1457Uncharacterized protein YdcD; Pseudogene, Rhs family.
ydcC protein networkhttps://string-db.org/network/511145.b1460H repeat-associated putative transposase YdcC; Pseudogene; Belongs to the transposase 11 family.
pptA protein networkhttps://string-db.org/network/511145.b14614-oxalocrotonate tautomerase; Can use enol isomers of phenylpyruvate, 2-hydroxy-2,4- pentadienoate and (p-hydroxyphenyl)pyruvate as substrates. Belongs to the 4-oxalocrotonate tautomerase family. [...]
yddH protein networkhttps://string-db.org/network/511145.b1462Flavin reductase like-protein.
nhoA protein networkhttps://string-db.org/network/511145.b1463N-hydroxyarylamine O-acetyltransferase; Catalyzes the acetyl-CoA-dependent N-acetylation of aromatic amines, and, probably, the O-acetylation of N-hydroxyarylamines. In vitro, catalyzes the N-ace [...]
yddE protein networkhttps://string-db.org/network/511145.b1464PhzC-PhzF family protein.
narV protein networkhttps://string-db.org/network/511145.b1465Nitrate reductase 2 (NRZ), gamma subunit; This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerob [...]
narW protein networkhttps://string-db.org/network/511145.b1466Nitrate reductase 2 (NRZ), delta subunit (assembly subunit); Chaperone required for proper molybdenum cofactor insertion and final assembly of the membrane-bound respiratory nitrate reductase 2.
narY protein networkhttps://string-db.org/network/511145.b1467Nitrate reductase 2 (NRZ), beta subunit; This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerobi [...]
narZ protein networkhttps://string-db.org/network/511145.b1468Nitrate reductase 2 (NRZ), alpha subunit; This is a second nitrate reductase enzyme which can substitute for the NRA enzyme and allows E.coli to use nitrate as an electron acceptor during anaerob [...]
narU protein networkhttps://string-db.org/network/511145.b1469Nitrate/nitrite transporter; Catalyzes nitrate uptake, nitrite uptake and nitrite export across the cytoplasmic membrane. May function as a nitrate/H(+) and nitrite/H(+) channel. Could confer a s [...]
yddG protein networkhttps://string-db.org/network/511145.b1473Aromatic amino acid exporter YddG; Probable efflux pump. Overexpression confers resistance to phenylalanine and increases export of phenylalanine, tyrosine and tryptophan; Belongs to the drug/met [...]
fdnG protein networkhttps://string-db.org/network/511145.b1474Formate dehydrogenase-N, alpha subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as electro [...]
fdnH protein networkhttps://string-db.org/network/511145.b1475Formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate is used as e [...]
fdnI protein networkhttps://string-db.org/network/511145.b1476Formate dehydrogenase-N, cytochrome B556 (gamma) subunit, nitrate-inducible; Formate dehydrogenase allows E.coli to use formate as major electron donor during anaerobic respiration, when nitrate [...]
yddM protein networkhttps://string-db.org/network/511145.b1477Putative DNA-binding transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the VapA/VapI family.
adhP protein networkhttps://string-db.org/network/511145.b1478Ethanol-active dehydrogenase/acetaldehyde-active reductase; Preferred specificity is towards 1-propanol; Belongs to the zinc-containing alcohol dehydrogenase family.
maeA protein networkhttps://string-db.org/network/511145.b1479Malate dehydrogenase, decarboxylating, NAD-requiring; NAD-linked malate dehydrogenase (malic enzyme); Protein involved in gluconeogenesis.
sra protein networkhttps://string-db.org/network/511145.b1480Stationary-phase-induced ribosome-associated protein; Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein. Belongs to th [...]
bdm protein networkhttps://string-db.org/network/511145.b1481Biofilm-dependent modulation protein.
osmC protein networkhttps://string-db.org/network/511145.b1482Lipoyl-dependent Cys-based peroxidase, hydroperoxide resistance; Preferentially metabolizes organic hydroperoxides over inorganic hydrogen peroxide; Belongs to the OsmC/Ohr family.
ddpF protein networkhttps://string-db.org/network/511145.b1483D,D-dipeptide ABC transporter ATPase; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transpor [...]
ddpD protein networkhttps://string-db.org/network/511145.b1484D,D-dipeptide ABC transporter ATPase; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for energy coupling to the transpor [...]
ddpC protein networkhttps://string-db.org/network/511145.b1485D,D-dipeptide ABC transporter permease; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the subs [...]
ddpB protein networkhttps://string-db.org/network/511145.b1486D,D-dipeptide ABC transporter permease; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport. Probably responsible for the translocation of the subs [...]
ddpA protein networkhttps://string-db.org/network/511145.b1487D,D-dipeptide ABC transporter periplasmic binding protein; Part of the ABC transporter complex DdpABCDF, which is probably involved in D,D-dipeptide transport; Belongs to the bacterial solute-bin [...]
ddpX protein networkhttps://string-db.org/network/511145.b1488D-ala-D-ala dipeptidase, Zn-dependent; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. May have a role in cell-wall turnover.
dosP protein networkhttps://string-db.org/network/511145.b1489Oxygen sensor, c-di-GMP phosphodiesterase, heme-regulated; Heme-based oxygen sensor protein displaying phosphodiesterase (PDE) activity toward c-di-GMP in response to oxygen availability. Involve [...]
dosC protein networkhttps://string-db.org/network/511145.b1490Diguanylate cyclase, cold- and stationary phase-induced oxygen-dependent biofilm regulator; Globin-coupled heme-based oxygen sensor protein displaying diguanylate cyclase (DGC) activity in respon [...]
yddW protein networkhttps://string-db.org/network/511145.b1491Liprotein, glycosyl hydrolase homolog.
gadC protein networkhttps://string-db.org/network/511145.b1492Glutamate:gamma-aminobutyric acid antiporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced [...]
gadB protein networkhttps://string-db.org/network/511145.b1493Glutamate decarboxylase B, PLP-dependent; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral int [...]
pqqL protein networkhttps://string-db.org/network/511145.b1494Putative periplasmic M16 family zinc metalloendopeptidase; Putative zinc protease.
yddB protein networkhttps://string-db.org/network/511145.b1495Putative TonB-dependent outer membrane receptor; To H.influenzae HI_1369.
yddA protein networkhttps://string-db.org/network/511145.b1496Putative multidrug ABC transporter permease/ATPase.
ydeM protein networkhttps://string-db.org/network/511145.b1497Putative enzyme; Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.
ydeN protein networkhttps://string-db.org/network/511145.b1498Putative Ser-type periplasmic non-aryl sulfatase; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family.
ydeO protein networkhttps://string-db.org/network/511145.b1499UV-inducible global regulator, EvgA-, GadE-dependent; Induces the expression of gadE and mdtEF. Could also regulate the expression of other genes involved in acid resistance.
safA protein networkhttps://string-db.org/network/511145.b1500Two-component system connector membrane protein, EvgSA to PhoQP; Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and [...]
ydeP protein networkhttps://string-db.org/network/511145.b1501Putative oxidoreductase; Probably involved in acid resistance. Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
ydeQ protein networkhttps://string-db.org/network/511145.b1502Putative adhesin; similar to FimH protein.
ydeR protein networkhttps://string-db.org/network/511145.b1503Putative fimbrial-like protein.
ydeS protein networkhttps://string-db.org/network/511145.b1504Putative fimbrial-like protein.
hipA protein networkhttps://string-db.org/network/511145.b1507Serine/threonine-protein kinase toxin HipA; Toxic component of a type II toxin-antitoxin (TA) system, first identified by mutations that increase production of persister cells, a fraction of cell [...]
hipB protein networkhttps://string-db.org/network/511145.b1508Antitoxin of HipAB toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the toxic effect of cognate toxin HipA. Also neutralizes the toxic effect of n [...]
lsrK protein networkhttps://string-db.org/network/511145.b1511Autoinducer-2 kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of th [...]
lsrR protein networkhttps://string-db.org/network/511145.b1512Lsr operon transcriptional repressor; Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcri [...]
lsrA protein networkhttps://string-db.org/network/511145.b1513Autoinducer 2 import ATP-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system (Probable). [...]
lsrC protein networkhttps://string-db.org/network/511145.b1514Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate acro [...]
lsrD protein networkhttps://string-db.org/network/511145.b1515Autoinducer 2 import system permease protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate acro [...]
lsrB protein networkhttps://string-db.org/network/511145.b1516Autoinducer 2-binding protein; Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases (Probable); Belongs t [...]
lsrF protein networkhttps://string-db.org/network/511145.b1517Putative autoinducer-2 (AI-2) aldolase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer o [...]
lsrG protein networkhttps://string-db.org/network/511145.b1518Autoinducer-2 (AI-2) degrading protein LsrG; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conve [...]
tam protein networkhttps://string-db.org/network/511145.b1519Trans-aconitate methyltransferase; Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis-aconitate, isocitrate, and citrate at lower velociti [...]
yneE protein networkhttps://string-db.org/network/511145.b1520Bestrophin family putative inner membrane protein.
uxaB protein networkhttps://string-db.org/network/511145.b1521Altronate oxidoreductase, NAD-dependent; Altronate oxidoreductase; Protein involved in carbohydrate catabolic process.
yneF protein networkhttps://string-db.org/network/511145.b1522Putative membrane-bound diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
yneG protein networkhttps://string-db.org/network/511145.b1523DUF4186 family protein.
glsB protein networkhttps://string-db.org/network/511145.b1524Putative glutaminase; Protein involved in cellular amino acid catabolic process.
sad protein networkhttps://string-db.org/network/511145.b1525Succinate semialdehyde dehydrogenase, NAD(P)+-dependent; Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can al [...]
yneJ protein networkhttps://string-db.org/network/511145.b1526Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yneK protein networkhttps://string-db.org/network/511145.b1527Uncharacterized protein.
ydeA protein networkhttps://string-db.org/network/511145.b1528Arabinose efflux transporter, arabinose-inducible; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabo [...]
marC protein networkhttps://string-db.org/network/511145.b1529UPF0056 family inner membrane protein.
marR protein networkhttps://string-db.org/network/511145.b1530Transcriptional repressor of multiple antibiotic resistance; Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to [...]
marA protein networkhttps://string-db.org/network/511145.b1531Multiple antibiotic resistance transcriptional regulator; May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes su [...]
marB protein networkhttps://string-db.org/network/511145.b1532Periplasmic mar operon regulator; Multiple antibiotic resistance protein; Protein involved in response to drug and xenobiotic metabolic process.
eamA protein networkhttps://string-db.org/network/511145.b1533Cysteine and O-acetyl-L-serine efflux system; May be an export pump for cysteine and other metabolites of the cysteine pathway (such as N-acetyl-L-serine (NAS) and O-acetyl-L- serine (OAS)), and [...]
ydeE protein networkhttps://string-db.org/network/511145.b1534Putative transporter; A transporter able to export peptides. When overexpressed, allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in the presence of dipeptides Ala [...]
dgcZ protein networkhttps://string-db.org/network/511145.b1535Diguanylate cyclase, zinc-sensing; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. May act as a zinc sensor that controls, via c-di-GMP, post-translat [...]
ydeI protein networkhttps://string-db.org/network/511145.b1536Hydrogen peroxide resistance OB fold protein; putative periplasmic protein.
ydeJ protein networkhttps://string-db.org/network/511145.b1537Inactive PncC family protein; Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity.
dcp protein networkhttps://string-db.org/network/511145.b1538Dipeptidyl carboxypeptidase II; Removes dipeptides from the C-termini of N-blocked tripeptides, tetrapeptides and larger peptides. Belongs to the peptidase M3 family.
ydfG protein networkhttps://string-db.org/network/511145.b1539NADP-dependent 3-hydroxy acid dehydrogenase; NADP-dependent dehydrogenase with broad substrate specificity acting on 3-hydroxy acids. Catalyzes the NADP-dependent oxidation of L- allo-threonine t [...]
rspR protein networkhttps://string-db.org/network/511145.b1540Transcriptional repressor for rspAB; Repressor of the rspAB operon. Acts by binding directly to the upstream region of rspA.
ydfZ protein networkhttps://string-db.org/network/511145.b1541Selenoprotein, function unknown.
ydfI protein networkhttps://string-db.org/network/511145.b1542Putative oxidoreductase; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
ydfK protein networkhttps://string-db.org/network/511145.b1544Cold shock protein YdfK; Cryptic prophage Qin/Kim.
pinQ protein networkhttps://string-db.org/network/511145.b1545Qin prophage; putative site-specific recombinase; Belongs to the site-specific recombinase resolvase family.
tfaQ protein networkhttps://string-db.org/network/511145.b1546Qin prophage; Tail fiber assembly protein homolog from lambdoid prophage Qin; Belongs to the tfa family.
stfQ protein networkhttps://string-db.org/network/511145.b1547Qin prophage; putative side tail fibre assembly protein; Belongs to the tail fiber family.
ydfO protein networkhttps://string-db.org/network/511145.b1549Qin prophage; uncharacterized protein; To E.coli YbcV and YcgX.
gnsB protein networkhttps://string-db.org/network/511145.b1550Qin prophage; Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold- sensitive secG null mutation.
ynfN protein networkhttps://string-db.org/network/511145.b1551Qin prophage; cold shock-induced protein.
cspI protein networkhttps://string-db.org/network/511145.b1552Qin prophage; Cold shock-like protein.
rzpQ protein networkhttps://string-db.org/network/511145.b1553Rz-like protein, Qin prophage; Completely contained in another CDS.
rrrQ protein networkhttps://string-db.org/network/511145.b1554Qin prophage; Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity; Belongs to the glycosyl hydrolase 24 family.
ydfR protein networkhttps://string-db.org/network/511145.b1555Qin prophage; uncharacterized protein.
essQ protein networkhttps://string-db.org/network/511145.b1556Qin prophage; putative S lysis protein; Belongs to the lambda phage S protein family.
cspB protein networkhttps://string-db.org/network/511145.b1557Qin prophage; cold shock protein.
cspF protein networkhttps://string-db.org/network/511145.b1558Qin prophage; cold shock protein.
quuQ protein networkhttps://string-db.org/network/511145.b1559Qin prophage; Positively regulate expression of some phage genes. Bacterial host RNA polymerase modified by antitermination proteins transcribes through termination sites that otherwise prevent e [...]
ydfU protein networkhttps://string-db.org/network/511145.b1560Qin prophage; uncharacterized protein.
rem protein networkhttps://string-db.org/network/511145.b1561Qin prophage; uncharacterized protein.
hokD protein networkhttps://string-db.org/network/511145.b1562Qin prophage; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within 2 minutes; causes collapse of the transmembrane potential and arrest of res [...]
relE protein networkhttps://string-db.org/network/511145.b1563Qin prophage; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific, ribosome-dependent mRNA endoribonuclease that inhibits translation during amino acid starvation (the s [...]
relB protein networkhttps://string-db.org/network/511145.b1564Antitoxin of the RelE-RelB toxin-antitoxin syste; Antitoxin component of a type II toxin-antitoxin (TA) system. Counteracts the effect of cognate toxin RelE via direct protein-protein interaction [...]
ydfV protein networkhttps://string-db.org/network/511145.b1565Qin prophage; uncharacterized protein.
flxA protein networkhttps://string-db.org/network/511145.b1566Qin prophage; uncharacterized protein.
dicC protein networkhttps://string-db.org/network/511145.b1569Repressor protein of division inhibition gene dicB; This protein is a repressor of division inhibition gene dicB.
dicA protein networkhttps://string-db.org/network/511145.b1570Qin prophage; This protein is a repressor of division inhibition gene dicB.
ydfA protein networkhttps://string-db.org/network/511145.b1571Qin prophage; uncharacterized protein; To E.coli YdaF.
ydfB protein networkhttps://string-db.org/network/511145.b1572Qin prophage; uncharacterized protein.
ydfC protein networkhttps://string-db.org/network/511145.b1573Uncharacterized protein, Qin prophage.
dicB protein networkhttps://string-db.org/network/511145.b1575Qin prophage; Involved in cell division inhibition; this function can be repressed by DicA and DicC proteins as well as antitoxin CbeA (yeeU).
ydfD protein networkhttps://string-db.org/network/511145.b1576Qin prophage; uncharacterized protein.
rspB protein networkhttps://string-db.org/network/511145.b1580Starvation-sensing protein RspB; Not known; probable catabolic enzyme.
rspA protein networkhttps://string-db.org/network/511145.b1581Bifunctional D-altronate/D-mannonate dehydratase; Probably involved in the degradation of homoserine lactone (HSL) or of a metabolite of HSL that signals starvation.
ynfA protein networkhttps://string-db.org/network/511145.b1582UPF0060 family inner membrane protein.
ynfB protein networkhttps://string-db.org/network/511145.b1583UPF0482 family putative periplasmic protein.
speG protein networkhttps://string-db.org/network/511145.b1584Spermidine N(1)-acetyltransferase; Involved in the protection against polyamine toxicity by regulating their concentration. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA [...]
ynfC protein networkhttps://string-db.org/network/511145.b1585UPF0257 family lipoprotein.
ynfD protein networkhttps://string-db.org/network/511145.b1586DUF1161 family periplasmic protein.
ynfE protein networkhttps://string-db.org/network/511145.b1587Putative selenate reductase, periplasmic; Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds; Belongs to the prokaryotic molybdopterin-containing oxidoreductase [...]
ynfF protein networkhttps://string-db.org/network/511145.b1588S- and N-oxide reductase, A subunit, periplasmic; Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
ynfG protein networkhttps://string-db.org/network/511145.b1589Oxidoreductase, Fe-S subunit; Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.
ynfH protein networkhttps://string-db.org/network/511145.b1590Oxidoreductase, membrane subunit; Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. The C subunit anchors the other two subunits to the membrane and stabilize [...]
dmsD protein networkhttps://string-db.org/network/511145.b1591Twin-argninine leader-binding protein for DmsA and TorA; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be par [...]
clcB protein networkhttps://string-db.org/network/511145.b1592H(+)/Cl(-) exchange transporter; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance ( [...]
ynfK protein networkhttps://string-db.org/network/511145.b1593Putative dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to f [...]
mlc protein networkhttps://string-db.org/network/511145.b1594Glucosamine anaerobic growth regulon transcriptional repressor; Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake [...]
ynfL protein networkhttps://string-db.org/network/511145.b1595Putative transcriptional regulator LYSR-type; Protein involved in regulation of transcription, DNA-dependent; Belongs to the LysR transcriptional regulatory family.
ynfM protein networkhttps://string-db.org/network/511145.b1596Putative arabinose efflux transporter; Putative transport protein.
asr protein networkhttps://string-db.org/network/511145.b1597Acid shock-inducible periplasmic protein; Required for growth and/or survival at acidic conditions (pH 4.5). Needed for the adaptation process at pH 4.5 that enables cells to survive at extremely [...]
ydgD protein networkhttps://string-db.org/network/511145.b1598Putative peptidase; Belongs to the peptidase S1B family.
mdtI protein networkhttps://string-db.org/network/511145.b1599Multidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small [...]
mdtJ protein networkhttps://string-db.org/network/511145.b1600Multidrug efflux system transporter; Catalyzes the excretion of spermidine. Can also confer resistance to deoxycholate and SDS; Belongs to the drug/metabolite transporter (DMT) superfamily. Small [...]
tqsA protein networkhttps://string-db.org/network/511145.b1601Pheromone AI-2 transporter; Controls the transport of the quorum-sensing signal AI-2 either by enhancing its secretion or inhibiting its uptake and consequently represses biofilm formation and mo [...]
pntB protein networkhttps://string-db.org/network/511145.b1602Pyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; B [...]
pntA protein networkhttps://string-db.org/network/511145.b1603Pyridine nucleotide transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; [...]
ydgH protein networkhttps://string-db.org/network/511145.b1604DUF1471 family periplasmic protein; To E.coli YjfY.
ydgI protein networkhttps://string-db.org/network/511145.b1605Putative arginine/ornithine antiporter transporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathwa [...]
folM protein networkhttps://string-db.org/network/511145.b1606Dihydromonapterin reductase, NADPH-dependent; Catalyzes the reduction of dihydromonapterin to tetrahydromonapterin. Also has lower activity with dihydrofolate.
ydgC protein networkhttps://string-db.org/network/511145.b1607GlpM family inner membrane protein.
rstA protein networkhttps://string-db.org/network/511145.b1608Response regulator of RstAB two-component system; Member of the two-component regulatory system RstB/RstA.
rstB protein networkhttps://string-db.org/network/511145.b1609Sensory histidine kinase of RstAB two-component system; Member of the two-component regulatory system RstB/RstA. RstB functions as a membrane-associated protein kinase that phosphorylates RstA (P [...]
tus protein networkhttps://string-db.org/network/511145.b1610Inhibitor of replication at Ter, DNA-binding protein; Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the [...]
fumC protein networkhttps://string-db.org/network/511145.b1611Fumarate hydratase (fumarase C),aerobic Class II; Involved in the TCA cycle. FumC seems to be a backup enzyme for FumA under conditions of iron limitation and oxidative stress. Catalyzes the ster [...]
fumA protein networkhttps://string-db.org/network/511145.b1612Fumarate hydratase (fumarase A), aerobic Class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Functions as an aerobic enzyme in the direction of malate formation as part of the [...]
manA protein networkhttps://string-db.org/network/511145.b1613Mannose-6-phosphate isomerase; Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide.
ydgA protein networkhttps://string-db.org/network/511145.b1614DUF945 family protein.
uidC protein networkhttps://string-db.org/network/511145.b1615Putative outer membrane porin for beta-glucuronides porin protein; Enhances the activity of the UidB (GusB) glucuronide transporter, on its own however it has no transport activity. Glucuronide t [...]
uidB protein networkhttps://string-db.org/network/511145.b1616Glucuronide permease; Protein involved in carbohydrate catabolic process.
uidA protein networkhttps://string-db.org/network/511145.b1617beta-D-glucuronidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family.
uidR protein networkhttps://string-db.org/network/511145.b1618Transcriptional repressor; Repressor for the uidRABC (gusRABC) operon.
hdhA protein networkhttps://string-db.org/network/511145.b16197-alpha-hydroxysteroid dehydrogenase, NAD-dependent; Catalyzes the oxidation of the 7-alpha-hydroxy group of primary bile acids such as cholate, chenodeoxycholate and taurochenodeoxycholate. To a [...]
malI protein networkhttps://string-db.org/network/511145.b1620Transcriptional repressor of Mal regulon; Repressor for the malX and malY genes. Also regulates its own expression. Binds maltose as an inducer.
malX protein networkhttps://string-db.org/network/511145.b1621Maltose and glucose-specific PTS enzyme IIB component and IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport syste [...]
malY protein networkhttps://string-db.org/network/511145.b1622PLP-dependent beta-cystathionase and maltose regulon regulator; Acts as a beta-cystathionase and as a repressor of the maltose regulon.
add protein networkhttps://string-db.org/network/511145.b1623Adenosine deaminase; Protein involved in nucleobase, nucleoside and nucleotide interconversion; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adeno [...]
ydgJ protein networkhttps://string-db.org/network/511145.b1624Putative oxidoreductase.
cnu protein networkhttps://string-db.org/network/511145.b1625Nucleoid-associated oriC-binding protein; Modifies the set of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of genes bound by H-NS/StpA and may also modulate the oligomerization [...]
ydgK protein networkhttps://string-db.org/network/511145.b1626DUF2569 family inner membrane protein.
rsxA protein networkhttps://string-db.org/network/511145.b1627SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
rsxB protein networkhttps://string-db.org/network/511145.b1628SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
rsxC protein networkhttps://string-db.org/network/511145.b1629SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
rsxD protein networkhttps://string-db.org/network/511145.b1630SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
rsxG protein networkhttps://string-db.org/network/511145.b1631SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
rsxE protein networkhttps://string-db.org/network/511145.b1632SoxR iron-sulfur cluster reduction factor component; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane (By similarity). Required to ma [...]
nth protein networkhttps://string-db.org/network/511145.b1633DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various d [...]
dtpA protein networkhttps://string-db.org/network/511145.b1634Dipeptide and tripeptide permease A; Proton-dependent permease that transports di- and tripeptides as well as structurally related peptidomimetics such as aminocephalosporins into the cell. Has a [...]
gstA protein networkhttps://string-db.org/network/511145.b1635Glutathionine S-transferase; Catalyzes the conjugation of reduced glutathione (GSH) to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows activity toward 1-chloro-2,4-dini [...]
pdxY protein networkhttps://string-db.org/network/511145.b1636Pyridoxamine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP in vivo, but shows very low activity compa [...]
tyrS protein networkhttps://string-db.org/network/511145.b1637tyrosyl-tRNA synthetase; Catalyzes the attachment of L-tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end o [...]
pdxH protein networkhttps://string-db.org/network/511145.b1638Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
mliC protein networkhttps://string-db.org/network/511145.b1639Inhibitor of c-type lysozyme, membrane-bound; Specifically inhibits C-type lysozymes. Belongs to the MliC family. Type 1 subfamily.
anmK protein networkhttps://string-db.org/network/511145.b1640anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating Mur [...]
slyB protein networkhttps://string-db.org/network/511145.b1641Putative outer membrane protein; Belongs to the Pcp/SlyB lipoprotein family.
slyA protein networkhttps://string-db.org/network/511145.b1642Global transcriptional regulator; Transcription regulator that can specifically activate or repress expression of target genes. Activates expression of genes such as molecular chaperones (groL, g [...]
ydhI protein networkhttps://string-db.org/network/511145.b1643DUF1656 family putative inner membrane efflux pump associated protein.
ydhJ protein networkhttps://string-db.org/network/511145.b1644Putative membrane fusion protein (MFP) of YdhJK efflux pump; Putative membrane protein.
ydhK protein networkhttps://string-db.org/network/511145.b1645Putative efflux protein (PET) component of YdhJK efflux pump.
sodC protein networkhttps://string-db.org/network/511145.b1646Superoxide dismutase, Cu, Zn, periplasmic; Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
ydhF protein networkhttps://string-db.org/network/511145.b1647Putative oxidoreductase; May function as oxidoreductase.
ydhL protein networkhttps://string-db.org/network/511145.b1648DUF1289 family protein.
nemR protein networkhttps://string-db.org/network/511145.b1649Transcriptional repressor for the nemRA-gloA operon, quinone-, glyoxal-, and HOCl-activated; Involved in response to both electrophiles and reactive chlorine species (RCS). Represses the transcri [...]
nemA protein networkhttps://string-db.org/network/511145.b1650Chromate reductase, quinone reductase, FMN-linked; Involved in the degradation of toxic compounds. Can use a variety of substrates, including the nitrate ester explosives glycerol trinitrate (GTN [...]
gloA protein networkhttps://string-db.org/network/511145.b1651Glyoxalase I, Ni-dependent; Catalyzes the isomerization of the hemithioacetal formed spontaneously from methylglyoxal and glutathione, to S- lactoylglutathione, which is then hydrolyzed by a type [...]
rnt protein networkhttps://string-db.org/network/511145.b1652RNase T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue [...]
lhr protein networkhttps://string-db.org/network/511145.b1653Member of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family.
grxD protein networkhttps://string-db.org/network/511145.b1654Glutaredoxin-4; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters; Belongs to the glutaredoxin family. Monothiol subfamily.
mepH protein networkhttps://string-db.org/network/511145.b1655Murein DD-endopeptidase, space-maker hydrolase; A murein DD-endopeptidase with specificity for D-Ala-meso- diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mDAP cross- [...]
sodB protein networkhttps://string-db.org/network/511145.b1656Superoxide dismutase, Fe; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismu [...]
ydhP protein networkhttps://string-db.org/network/511145.b1657Putative MFS transporter, inner membrane protein; Putative transport protein.
purR protein networkhttps://string-db.org/network/511145.b1658Transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN [...]
ydhB protein networkhttps://string-db.org/network/511145.b1659Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
ydhC protein networkhttps://string-db.org/network/511145.b1660Putative arabinose efflux transporter; Putative transport protein.
cfa protein networkhttps://string-db.org/network/511145.b1661Cyclopropane fatty acyl phospholipid synthase, SAM-dependent; Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the r [...]
ribC protein networkhttps://string-db.org/network/511145.b1662Riboflavin synthase, alpha subunit; Catalyzes the dismutation of two molecules of 6,7-dimethyl-8- ribityllumazine, resulting in the formation of riboflavin and 5-amino- 6-(D-ribitylamino)uracil.
mdtK protein networkhttps://string-db.org/network/511145.b1663Multidrug efflux system transporter; Multidrug efflux pump that probably functions as a Na(+)/drug antiporter. Confers resistance to many drugs such as fluoroquinolones (norfloxacin, ciprofloxaci [...]
ydhQ protein networkhttps://string-db.org/network/511145.b1664Autotransporter adhesin-related protein; Possible enzyme.
ydhR protein networkhttps://string-db.org/network/511145.b1667Putative monooxygenase; May function as monooxygenase and play a role in the metabolism of aromatic compounds.
ydhS protein networkhttps://string-db.org/network/511145.b1668Putative oxidoreductase.
ydhT protein networkhttps://string-db.org/network/511145.b1669FNR, Nar, NarP-regulated protein; putative subunit of YdhYVWXUT oxidoreductase complex.
ydhU protein networkhttps://string-db.org/network/511145.b1670Putative cytochrome b subunit of YdhYVWXUT oxidoreductase complex.
ydhX protein networkhttps://string-db.org/network/511145.b1671Putative 4Fe-4S ferridoxin-type protein; Putative oxidoreductase, Fe-S subunit.
ydhW protein networkhttps://string-db.org/network/511145.b1672FNR, Nar, NarP-regulated protein; putative subunit of YdhYVWXUT oxidoreductase complex.
ydhV protein networkhttps://string-db.org/network/511145.b1673Putative oxidoreductase subunit.
ydhY protein networkhttps://string-db.org/network/511145.b1674Putative 4Fe-4S ferridoxin-type protein; Putative oxidoreductase, Fe-S subunit.
ydhZ protein networkhttps://string-db.org/network/511145.b1675Uncharacterized protein; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as substrate.
pykF protein networkhttps://string-db.org/network/511145.b1676Pyruvate kinase I (formerly F), fructose stimulated; Protein involved in glycolysis, fermentation and anaerobic respiration.
lpp protein networkhttps://string-db.org/network/511145.b1677Murein lipoprotein; An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein k [...]
ldtE protein networkhttps://string-db.org/network/511145.b1678Murein L,D-transpeptidase; Responsible, at least in part, for generating a meso- diaminopimelyl-3-a meso-diaminopimelyl-3 cross-link.
sufE protein networkhttps://string-db.org/network/511145.b1679Sulfur acceptor protein; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in [...]
sufS protein networkhttps://string-db.org/network/511145.b1680Cysteine desulfurase, stimulated by SufE; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sul [...]
sufD protein networkhttps://string-db.org/network/511145.b1681Component of SufBCD Fe-S cluster assembly scaffold; The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the [...]
sufC protein networkhttps://string-db.org/network/511145.b1682SufBCD Fe-S cluster assembly scaffold protein, ATP-binding protein; Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of Su [...]
sufB protein networkhttps://string-db.org/network/511145.b1683Component of SufBCD Fe-S cluster assembly scaffold; The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the [...]
sufA protein networkhttps://string-db.org/network/511145.b1684Fe-S cluster assembly protein.
ydiH protein networkhttps://string-db.org/network/511145.b1685Uncharacterized protein.
menI protein networkhttps://string-db.org/network/511145.b16861,4-dihydroxy-2-naphthoyl-CoA hydrolase; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). Also shows significant activity toward a wide r [...]
ydiJ protein networkhttps://string-db.org/network/511145.b1687Putative FAD-linked oxidoreductase; Putative oxidase.
ydiK protein networkhttps://string-db.org/network/511145.b1688UPF0118 family inner membrane protein.
ydiL protein networkhttps://string-db.org/network/511145.b1689Putative HTH domain DNA-binding protein.
ydiM protein networkhttps://string-db.org/network/511145.b1690Putative MFS transporter, membrane protein; Putative transport system permease protein.
ydiN protein networkhttps://string-db.org/network/511145.b1691Putative MFS transporter, membrane protein; Putative amino acid/amine transport protein.
ydiB protein networkhttps://string-db.org/network/511145.b1692Quinate/shikimate 5-dehydrogenase, NAD(P)-binding; The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. [...]
aroD protein networkhttps://string-db.org/network/511145.b16933-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids (AroAA). Catalyzes the cis-dehydration of 3-dehydroquin [...]
ydiF protein networkhttps://string-db.org/network/511145.b1694Putative acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit/beta subunit; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing w [...]
ydiO protein networkhttps://string-db.org/network/511145.b1695Putative acyl-CoA dehydrogenase; Putative oxidoreductase; Belongs to the acyl-CoA dehydrogenase family.
ydiP protein networkhttps://string-db.org/network/511145.b1696Putative ARAC-type regulatory protein; Protein involved in transcription and regulation of transcription, DNA-dependent.
ydiQ protein networkhttps://string-db.org/network/511145.b1697Putative electron transfer flavoprotein subunit; May play a role in a redox process; Belongs to the ETF beta-subunit/FixA family.
ydiR protein networkhttps://string-db.org/network/511145.b1698Putative electron transfer flavoprotein, FAD-binding subunit; May play a role in a redox process; Belongs to the ETF alpha-subunit/FixB family.
ydiS protein networkhttps://string-db.org/network/511145.b1699Putative oxidoreductase; Probably accepts electrons from YdiQ/YdiR and reduces a quinone; Belongs to the ETF-QO/FixC family.
ydiT protein networkhttps://string-db.org/network/511145.b1700Putative 3Fe-4S ferredoxin-type protein; Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YdiQ, YdiR and YdiS.
fadK protein networkhttps://string-db.org/network/511145.b1701Short chain acyl-CoA synthetase, anaerobic; Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation [...]
ppsA protein networkhttps://string-db.org/network/511145.b1702Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
ppsR protein networkhttps://string-db.org/network/511145.b1703PEP synthase kinase and PEP synthase pyrophosphorylase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing [...]
aroH protein networkhttps://string-db.org/network/511145.b17043-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-a [...]
ydiE protein networkhttps://string-db.org/network/511145.b1705Hemin uptake protein HemP homolog; To Y.enterocolitica HemP.
ydiU protein networkhttps://string-db.org/network/511145.b1706UPF0061 family protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). Cannot use GTP, CTP or UTP as cosubstrate. AMPylat [...]
ydiV protein networkhttps://string-db.org/network/511145.b1707anti-FlhD4C2 factor, inactive EAL family phosphodiesterase; Upon overexpression acts as a novel anti-FlhC(2)FlhD(4) factor, decreasing its DNA-binding activity, able to negatively regulate expres [...]
nlpC protein networkhttps://string-db.org/network/511145.b1708Putative C40 clan peptidase lipoprotein; Lipoprotein.
btuD protein networkhttps://string-db.org/network/511145.b1709Vitamin B12 ABC transporter ATPase; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
btuE protein networkhttps://string-db.org/network/511145.b1710Glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent. In vitro, utilizes preferentially thioredoxin A to decompose hydrogen peroxide as well [...]
btuC protein networkhttps://string-db.org/network/511145.b1711Vitamin B12 ABC transporter permease; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane; Belongs to the [...]
ihfA protein networkhttps://string-db.org/network/511145.b1712Integration host factor (IHF), DNA-binding protein, alpha subunit; One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination a [...]
pheT protein networkhttps://string-db.org/network/511145.b1713Phenylalanine tRNA synthetase, beta-subunit; Protein involved in tRNA aminoacylation for protein translation.
pheS protein networkhttps://string-db.org/network/511145.b1714Phenylalanine tRNA synthetase, alpha-subunit; Protein involved in tRNA aminoacylation for protein translation.
pheM protein networkhttps://string-db.org/network/511145.b1715phenylalanyl-tRNA synthetase (pheST) operon leader peptide; Protein involved in tRNA aminoacylation for protein translation.
rplT protein networkhttps://string-db.org/network/511145.b171650S ribosomal subunit protein L20; One of the primary rRNA binding proteins, it binds close to the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly.
rpmI protein networkhttps://string-db.org/network/511145.b171750S ribosomal subunit protein A; Protein involved in structural constituent of ribosome and translation; Belongs to the bacterial ribosomal protein bL35 family.
infC protein networkhttps://string-db.org/network/511145.b1718Translation initiation factor IF-3; One of the essential components for the initiation of protein synthesis.IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes [...]
thrS protein networkhttps://string-db.org/network/511145.b1719threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor en [...]
ydiY protein networkhttps://string-db.org/network/511145.b1722Acid-inducible putative outer membrane protein.
pfkB protein networkhttps://string-db.org/network/511145.b17236-phosphofructokinase II; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
ydiZ protein networkhttps://string-db.org/network/511145.b1724Uncharacterized protein.
yniA protein networkhttps://string-db.org/network/511145.b1725Fructosamine kinase family protein; Ketoamine kinase that phosphorylates ketoamines on the third carbon of the sugar moiety to generate ketoamine 3-phosphate (By similarity). Its precise substrat [...]
yniB protein networkhttps://string-db.org/network/511145.b1726Putative inner membrane protein.
yniC protein networkhttps://string-db.org/network/511145.b17272-deoxyglucose-6-P phosphatase; Sugar-phosphate phosphohydrolase that catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Also catalyzes the dephosphorylation of [...]
ydjM protein networkhttps://string-db.org/network/511145.b1728Inner membrane protein regulated by LexA; Protein involved in SOS response; To B.subtilis YvsG.
ydjN protein networkhttps://string-db.org/network/511145.b1729Putative transporter; Involved in L-cystine transport. Can probably also transport L-cysteine. Mediates accumulation of the toxic compounds L- selenaproline (SCA) and L-selenocystine (SeCys). Bel [...]
ydjO protein networkhttps://string-db.org/network/511145.b1730Uncharacterized protein.
cedA protein networkhttps://string-db.org/network/511145.b1731Cell division modulator; Activates the cell division inhibited by chromosomal DNA over-replication; Belongs to the CedA family.
katE protein networkhttps://string-db.org/network/511145.b1732Catalase HPII, heme d-containing; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
chbG protein networkhttps://string-db.org/network/511145.b1733Chito-oligosaccharide deacetylase; ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, [...]
chbF protein networkhttps://string-db.org/network/511145.b1734Phospho-chitobiase; Hydrolyzes a wide variety of P-beta-glucosides including cellobiose-6P, salicin-6P, arbutin-6P, gentiobiose-6P, methyl-beta- glucoside-6P and p-nitrophenyl-beta-D-glucopyranos [...]
chbR protein networkhttps://string-db.org/network/511145.b1735Repressor of chb operon for N,N'-diacetylchitobiose utilization; Dual-function repressor/activator of the chbBCARFG operon. In the absence of the inducing sugar chitobiose, together with NagC, re [...]
chbA protein networkhttps://string-db.org/network/511145.b1736N,N'-diacetylchitobiose-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyze [...]
chbC protein networkhttps://string-db.org/network/511145.b1737N,N'-diacetylchitobiose-specific enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyze [...]
chbB protein networkhttps://string-db.org/network/511145.b1738N,N'-diacetylchitobiose-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyze [...]
osmE protein networkhttps://string-db.org/network/511145.b1739Osmotically-inducible lipoprotein; Activator of ntrL gene; Protein involved in transcription activator activity, transcription and response to osmotic stress.
nadE protein networkhttps://string-db.org/network/511145.b1740NAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
cho protein networkhttps://string-db.org/network/511145.b1741Endonuclease of nucleotide excision repair; Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incis [...]
ves protein networkhttps://string-db.org/network/511145.b1742Cold- and stress-inducible protein; Belongs to the Ves family.
spy protein networkhttps://string-db.org/network/511145.b1743Periplasmic ATP-independent protein refolding chaperone, stress-induced; An ATP-independent periplasmic chaperone, decreases protein aggregation and helps protein refolding. Binds substrate over [...]
astE protein networkhttps://string-db.org/network/511145.b1744Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
astB protein networkhttps://string-db.org/network/511145.b1745Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).
astD protein networkhttps://string-db.org/network/511145.b1746Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. Also shows activity with decanal or succinic semialdeh [...]
astA protein networkhttps://string-db.org/network/511145.b1747Arginine succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
astC protein networkhttps://string-db.org/network/511145.b1748Succinylornithine transaminase, PLP-dependent; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act [...]
xthA protein networkhttps://string-db.org/network/511145.b1749Exonuclease III; Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction. [...]
ydjX protein networkhttps://string-db.org/network/511145.b1750TVP38/TMEM64 family inner membrane protein; Belongs to the TVP38/TMEM64 family.
ydjY protein networkhttps://string-db.org/network/511145.b1751Putative ferrodoxin-like lipoprotein.
ydjZ protein networkhttps://string-db.org/network/511145.b1752TVP38/TMEM64 family inner membrane protein; Belongs to the TVP38/TMEM64 family.
ynjA protein networkhttps://string-db.org/network/511145.b1753Carboxymuconolactone decarboxylase family protein; To M.tuberculosis Rv2313c.
ynjB protein networkhttps://string-db.org/network/511145.b1754Putative ABC transporter periplasmic binding protein.
ynjC protein networkhttps://string-db.org/network/511145.b1755Putative ABC transporter permease; Probably part of the binding-protein-dependent transport system YnjCD. Probably responsible for the translocation of the substrate across the membrane.
ynjD protein networkhttps://string-db.org/network/511145.b1756Putative ABC transporter ATPase; Probably part of a binding-protein-dependent transport system YnjCD. Probably responsible for energy coupling to the transport system.
ynjE protein networkhttps://string-db.org/network/511145.b1757Molybdopterin synthase sulfurtransferase; Putative thiosulfate sulfur transferase; Protein involved in sulfur metabolic process.
ynjF protein networkhttps://string-db.org/network/511145.b1758CDP-alcohol phosphatidyltransferase family inner membrane protein; Putative cytochrome oxidase.
nudG protein networkhttps://string-db.org/network/511145.b1759CTP pyrophosphohydrolase; Hydrolase with a preference for pyrimidine substrates. Has high activity with 5-methyl-dCTP, and much lower activity with CTP, dCTP, 5-hydroxy-dCTP, 2-hydroxy-dATP and 8 [...]
ynjH protein networkhttps://string-db.org/network/511145.b1760DUF1496 family protein.
gdhA protein networkhttps://string-db.org/network/511145.b1761Glutamate dehydrogenase, NADP-specific; Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
ynjI protein networkhttps://string-db.org/network/511145.b1762Inner membrane protein.
topB protein networkhttps://string-db.org/network/511145.b1763DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand o [...]
selD protein networkhttps://string-db.org/network/511145.b1764Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP; Belongs to the selenophosphate synthase 1 family. Class I subfamily.
ydjA protein networkhttps://string-db.org/network/511145.b1765Putative oxidoreductase; Belongs to the nitroreductase family.
sppA protein networkhttps://string-db.org/network/511145.b1766Protease IV (signal peptide peptidase); Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins acros [...]
ansA protein networkhttps://string-db.org/network/511145.b1767Cytoplasmic L-asparaginase 1; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.
pncA protein networkhttps://string-db.org/network/511145.b1768Nicotinamidase/pyrazinamidase; Catalyzes the deamidation of nicotinamide (NAM) into nicotinate. Likely functions in the cyclical salvage pathway for production of NAD from nicotinamide.
ydjE protein networkhttps://string-db.org/network/511145.b1769Putative MFS sugar transporter, membrane protein; Putative transport protein.
ydjF protein networkhttps://string-db.org/network/511145.b1770Putative DEOR-type transcriptional regulator; Protein involved in transcription and regulation of transcription, DNA-dependent.
ydjG protein networkhttps://string-db.org/network/511145.b1771Methylglyoxal reductase, NADH-dependent; Catalyzes the NADH-dependent reduction of methylglyoxal (2- oxopropanal) in vitro. It is not known if this activity has physiological significance. Cannot [...]
ydjH protein networkhttps://string-db.org/network/511145.b1772Putative kinase; Belongs to the carbohydrate kinase PfkB family.
ydjI protein networkhttps://string-db.org/network/511145.b1773Putative aldolase.
ydjJ protein networkhttps://string-db.org/network/511145.b1774Putative oxidoreductase.
ydjK protein networkhttps://string-db.org/network/511145.b1775Putative MFS sugar transporter, membrane protein; Putative transport protein.
ydjL protein networkhttps://string-db.org/network/511145.b1776Putative Zn-dependent NAD(P)-binding oxidoreductase.
yeaC protein networkhttps://string-db.org/network/511145.b1777DUF1315 family protein.
msrB protein networkhttps://string-db.org/network/511145.b1778Methionine sulfoxide reductase B.
gapA protein networkhttps://string-db.org/network/511145.b1779Glyceraldehyde-3-phosphate dehydrogenase A; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reactio [...]
yeaD protein networkhttps://string-db.org/network/511145.b1780D-hexose-6-phosphate epimerase-like protein; Belongs to the glucose-6-phosphate 1-epimerase family.
yeaE protein networkhttps://string-db.org/network/511145.b1781Aldo-keto reductase, methylglyoxal to acetol, NADPH-dependent; Putative an aldehyde reductase.
mipA protein networkhttps://string-db.org/network/511145.b1782Scaffolding protein for murein synthesizing machinery; May serve as a scaffold protein required for the formation of a complex with MrcB/PonB and MltA, this complex could play a role in enlargeme [...]
yeaG protein networkhttps://string-db.org/network/511145.b1783Protein kinase, endogenous substrate unidentified; autokinase; Belongs to the PrkA family.
yeaH protein networkhttps://string-db.org/network/511145.b1784UPF0229 family protein; Belongs to the UPF0229 family.
yeaI protein networkhttps://string-db.org/network/511145.b1785Putative membrane-anchored diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
yeaJ protein networkhttps://string-db.org/network/511145.b1786Putative diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules.
yeaK protein networkhttps://string-db.org/network/511145.b1787aminoacyl-tRNA editing domain protein.
yoaI protein networkhttps://string-db.org/network/511145.b1788Uncharacterized protein.
yeaL protein networkhttps://string-db.org/network/511145.b1789UPF0756 family putative inner membrane protein.
yeaM protein networkhttps://string-db.org/network/511145.b1790Putative DNA-binding transcriptional regulator; Negatively regulates expression of the nimT operon and its own expression. Acts by binding to the nimR-nimT intergenic region.
yeaN protein networkhttps://string-db.org/network/511145.b1791Putative MFS transporter, inner membrane protein; Involved in efflux of 2-nitroimidazole. Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family.
yeaO protein networkhttps://string-db.org/network/511145.b1792DUF488 family protein; To M.tuberculosis Rv3073c.
yoaF protein networkhttps://string-db.org/network/511145.b1793DUF333 family outer membrane lipoprotein.
yeaP protein networkhttps://string-db.org/network/511145.b1794Diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits [...]
yeaQ protein networkhttps://string-db.org/network/511145.b1795UPF0410 family protein.
yoaG protein networkhttps://string-db.org/network/511145.b1796Uncharacterized protein.
yeaR protein networkhttps://string-db.org/network/511145.b1797DUF1971 family protein, nitrate-inducible; Protein involved in xenobiotic metabolic process.
leuE protein networkhttps://string-db.org/network/511145.b1798Leucine efflux protein; Exporter of leucine. Can also transport its natural analog L- alpha-amino-n-butyric acid and some other structurally unrelated amino acids.
dmlR protein networkhttps://string-db.org/network/511145.b1799Transcriptional activator of dmlA; Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or [...]
dmlA protein networkhttps://string-db.org/network/511145.b1800D-malate oxidase, NAD-dependent; Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D-malate as the sole carbon source. But is [...]
yeaV protein networkhttps://string-db.org/network/511145.b1801Putative transporter; Probable transporter whose substrate is unknown. Is not involved in aerobic D-malate transport.
yeaW protein networkhttps://string-db.org/network/511145.b1802Putative YeaWX dioxygenase alpha subunit; Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates.
yeaX protein networkhttps://string-db.org/network/511145.b1803Putative YeaWX dioxygenase beta subunit, reductase component; Converts carnitine to trimethylamine and malic semialdehyde. Can also use gamma-butyrobetaine, choline and betaine as substrates.
rnd protein networkhttps://string-db.org/network/511145.b1804Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RN [...]
fadD protein networkhttps://string-db.org/network/511145.b1805acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase); Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for [...]
yeaY protein networkhttps://string-db.org/network/511145.b1806Slp family lipoprotein, RpoE-regulated; Putative outer membrane protein.
tsaB protein networkhttps://string-db.org/network/511145.b1807tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginnin [...]
yoaA protein networkhttps://string-db.org/network/511145.b1808Putative ATP-dependent helicase, DinG family; DNA-dependent ATPase and 5'-3' DNA helicase (By similarity). Involved in the repair of replication forks and tolerance of the chain- terminating nucl [...]
yoaB protein networkhttps://string-db.org/network/511145.b1809Putative reactive intermediate deaminase; Belongs to the RutC family.
yoaC protein networkhttps://string-db.org/network/511145.b1810DUF1889 family protein.
yoaH protein networkhttps://string-db.org/network/511145.b1811UPF0181 family protein; Belongs to the UPF0181 family.
pabB protein networkhttps://string-db.org/network/511145.b1812Aminodeoxychorismate synthase, subunit I; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and t [...]
nudL protein networkhttps://string-db.org/network/511145.b1813Putative CoA pyrophosphohydrolase, weak 3-phosphohydroxypyruvate phosphatase; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. P [...]
sdaA protein networkhttps://string-db.org/network/511145.b1814L-serine dehydratase 1; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family.
yoaD protein networkhttps://string-db.org/network/511145.b1815Putative membrane-anchored cyclic-di-GMP phosphodiesterase, regulator of cellulose production; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By sim [...]
yoaE protein networkhttps://string-db.org/network/511145.b1816Putative transport protein.
manX protein networkhttps://string-db.org/network/511145.b1817Fused mannose-specific PTS enzymes: IIA component/IIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catal [...]
manY protein networkhttps://string-db.org/network/511145.b1818Mannose-specific enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphoryl [...]
manZ protein networkhttps://string-db.org/network/511145.b1819Mannose-specific enzyme IID component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphoryl [...]
yobD protein networkhttps://string-db.org/network/511145.b1820UPF0266 family inner membrane protein.
mntP protein networkhttps://string-db.org/network/511145.b1821Putative Mn(2+) efflux pump, mntR-regulated; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.
rlmA protein networkhttps://string-db.org/network/511145.b182223S rRNA m(1)G745 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 745 of 23S rRNA.
cspC protein networkhttps://string-db.org/network/511145.b1823Stress protein, member of the CspA-family; Cold shock protein; Protein involved in transcription activator activity, transcription and response to temperature stimulus.
yobF protein networkhttps://string-db.org/network/511145.b1824DUF2527 family heat-induced protein.
yebO protein networkhttps://string-db.org/network/511145.b1825Putative inner membrane protein.
mgrB protein networkhttps://string-db.org/network/511145.b1826Regulatory peptide for PhoPQ, feedback inhibition; Represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP [...]
kdgR protein networkhttps://string-db.org/network/511145.b1827KDG regulon transcriptional repressor; Transcriptional regulator of the kdgK gene for the kdg kinase and the kdgT gene for the kdg permease.
yebQ protein networkhttps://string-db.org/network/511145.b1828Putative transport protein.
htpX protein networkhttps://string-db.org/network/511145.b1829Putative endopeptidase; Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic s [...]
prc protein networkhttps://string-db.org/network/511145.b1830Carboxy-terminal protease for penicillin-binding protein 3; Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be [...]
proQ protein networkhttps://string-db.org/network/511145.b1831RNA chaperone, putative ProP translation regulator; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, [...]
msrC protein networkhttps://string-db.org/network/511145.b1832Free methionine-(R)-sulfoxide reductase; Catalyzes the reversible oxidation-reduction of the R- enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
yebS protein networkhttps://string-db.org/network/511145.b1833Inner membrane PqiA domain protein; Component of a transport pathway that contributes to membrane integrity; Belongs to the PqiA family.
yebT protein networkhttps://string-db.org/network/511145.b1834MCE domain protein; Component of a transport pathway that contributes to membrane integrity. May directly span the intermembrane space, facilitating the transport of substrates across the peripla [...]
rsmF protein networkhttps://string-db.org/network/511145.b183516S rRNA m(5)C1407 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
yebV protein networkhttps://string-db.org/network/511145.b1836Uncharacterized protein.
yebW protein networkhttps://string-db.org/network/511145.b1837Uncharacterized protein.
pphA protein networkhttps://string-db.org/network/511145.b1838Serine/threonine-specific protein phosphatase 1; Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phospho [...]
yebY protein networkhttps://string-db.org/network/511145.b1839DUF2511 family protein.
yebZ protein networkhttps://string-db.org/network/511145.b1840Inner membrane protein; Putative resistance protein; Protein involved in response to drug.
yobA protein networkhttps://string-db.org/network/511145.b1841CopC family protein.
holE protein networkhttps://string-db.org/network/511145.b1842DNA polymerase III, theta subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exo [...]
yobB protein networkhttps://string-db.org/network/511145.b1843C-N hydrolase family protein.
exoX protein networkhttps://string-db.org/network/511145.b1844Exodeoxyribonuclease 10; Capable of degrading both single-strand and double-strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA ends than for dsDNA.
ptrB protein networkhttps://string-db.org/network/511145.b1845Protease II; Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues; Belongs to the peptidase S9A family.
yebE protein networkhttps://string-db.org/network/511145.b1846DUF533 family inner membrane protein.
yebF protein networkhttps://string-db.org/network/511145.b1847Extracellular Colicin M immunity family protein.
yebG protein networkhttps://string-db.org/network/511145.b1848DNA damage-inducible protein regulated by LexA; Protein involved in DNA repair and SOS response.
purT protein networkhttps://string-db.org/network/511145.b1849Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N [...]
eda protein networkhttps://string-db.org/network/511145.b1850KHG/KDPG aldolase; Involved in the degradation of glucose via the Entner- Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-Keto-3-deoxy-6-phosphogluconate (KD [...]
edd protein networkhttps://string-db.org/network/511145.b18516-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate.
zwf protein networkhttps://string-db.org/network/511145.b1852Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone; Belongs to the glucose-6-phosphate dehydrogenase family.
yebK protein networkhttps://string-db.org/network/511145.b1853Putative DNA-binding transcriptional regulator; Represses the expression of the hex regulon (zwf, eda, glp and gap).
pykA protein networkhttps://string-db.org/network/511145.b1854Pyruvate kinase II, glucose stimulated; Protein involved in glycolysis, fermentation and anaerobic respiration.
lpxM protein networkhttps://string-db.org/network/511145.b1855Myristoyl-acyl carrier protein (ACP)-dependent acyltransferase; Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid [...]
mepM protein networkhttps://string-db.org/network/511145.b1856Murein DD-endopeptidase, space-maker hydrolase, septation protein; A murein DD-endopeptidase with specificity for D-Ala-meso- diaminopimelic acid (mDAP) cross-links. Its role is probably to cleav [...]
znuA protein networkhttps://string-db.org/network/511145.b1857Zinc ABC transporter periplasmic binding protein; Involved in the high-affinity zinc uptake transport system.
znuC protein networkhttps://string-db.org/network/511145.b1858Zinc ABC transporter ATPase; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamil [...]
znuB protein networkhttps://string-db.org/network/511145.b1859Zinc ABC transporter permease; Involved in the high-affinity zinc uptake transport system; Belongs to the ABC-3 integral membrane protein family.
ruvB protein networkhttps://string-db.org/network/511145.b1860ATP-dependent DNA helicase, component of RuvABC resolvasome; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating th [...]
ruvA protein networkhttps://string-db.org/network/511145.b1861Component of RuvABC resolvasome, regulatory subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it ma [...]
yebB protein networkhttps://string-db.org/network/511145.b1862DUF830 family protein; To E.coli YiiX.
ruvC protein networkhttps://string-db.org/network/511145.b1863Component of RuvABC resolvasome, endonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to st [...]
yebC protein networkhttps://string-db.org/network/511145.b1864UPF0082 family protein.
nudB protein networkhttps://string-db.org/network/511145.b1865Dihydroneopterin triphosphate pyrophosphatase; Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynt [...]
aspS protein networkhttps://string-db.org/network/511145.b1866aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor [...]
yecD protein networkhttps://string-db.org/network/511145.b1867Isochorismatase family protein; Belongs to the isochorismatase family.
yecE protein networkhttps://string-db.org/network/511145.b1868UPF0759 family protein; Belongs to the UPF0759 family.
yecN protein networkhttps://string-db.org/network/511145.b1869MAPEG family inner membrane protein.
cmoA protein networkhttps://string-db.org/network/511145.b1870carboxy-SAM synthase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM); Belongs to the class I-like SAM-binding methyltransferase superfamily. [...]
cmoB protein networkhttps://string-db.org/network/511145.b1871tRNA (cmo5U34)-carboxymethyltransferase, carboxy-SAM-dependent; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethox [...]
torZ protein networkhttps://string-db.org/network/511145.b1872Trimethylamine N-oxide reductase system III, catalytic subunit; Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also red [...]
torY protein networkhttps://string-db.org/network/511145.b1873TMAO reductase III (TorYZ), cytochrome c-type subunit; Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzym [...]
cutC protein networkhttps://string-db.org/network/511145.b1874Copper homeostasis protein; Participates in the control of copper homeostasis. Belongs to the CutC family.
yecM protein networkhttps://string-db.org/network/511145.b1875Putative metal-binding enzyme; To H.influenzae HI_1582/HI_1581.
argS protein networkhttps://string-db.org/network/511145.b1876Arginine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
yecT protein networkhttps://string-db.org/network/511145.b1877Uncharacterized protein; To R.meliloti R02472.
flhE protein networkhttps://string-db.org/network/511145.b1878Proton seal during flagellar secretion; Not essential for flagellar formation and function.
flhA protein networkhttps://string-db.org/network/511145.b1879Putative flagellar export pore protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belo [...]
flhB protein networkhttps://string-db.org/network/511145.b1880Flagellin export apparatus, substrate specificity protein; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute th [...]
cheZ protein networkhttps://string-db.org/network/511145.b1881Chemotaxis regulator, protein phosphatase for CheY; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY- [...]
cheY protein networkhttps://string-db.org/network/511145.b1882Chemotaxis regulator transmitting signal to flagellar motor component; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylat [...]
cheB protein networkhttps://string-db.org/network/511145.b1883Protein-glutamate methylesterase/protein-glutamine glutaminase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. C [...]
cheR protein networkhttps://string-db.org/network/511145.b1884Chemotaxis regulator, protein-glutamate methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.
tap protein networkhttps://string-db.org/network/511145.b1885Methyl-accepting protein IV; Mediates taxis toward dipeptides via an interaction with the periplasmic dipeptide-binding protein.
tar protein networkhttps://string-db.org/network/511145.b1886Methyl-accepting chemotaxis protein II; Receptor for the attractant L-aspartate and related amino and dicarboxylic acids. Tar also mediates taxis to the attractant maltose via an interaction with [...]
cheW protein networkhttps://string-db.org/network/511145.b1887Purine-binding chemotaxis protein; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemot [...]
cheA protein networkhttps://string-db.org/network/511145.b1888Chemotaxis protein CheA; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either [...]
motB protein networkhttps://string-db.org/network/511145.b1889Protein that enables flagellar motor rotation; MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Probably a linker that f [...]
motA protein networkhttps://string-db.org/network/511145.b1890Proton conductor component of flagella motor; MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton [...]
flhC protein networkhttps://string-db.org/network/511145.b1891Flagellar class II regulon transcriptional activator, with FlhD; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- fl [...]
flhD protein networkhttps://string-db.org/network/511145.b1892Flagellar class II regulon transcriptional activator, with FlhC; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- fl [...]
insB1-5 protein networkhttps://string-db.org/network/511145.b1893IS1 transposase B.
insA-4 protein networkhttps://string-db.org/network/511145.b1894IS1 repressor TnpA.
uspC protein networkhttps://string-db.org/network/511145.b1895Universal stress protein; Required for resistance to DNA-damaging agents.
otsA protein networkhttps://string-db.org/network/511145.b1896Trehalose-6-phosphate synthase; Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6- phosphate. Acts with retention of the [...]
otsB protein networkhttps://string-db.org/network/511145.b1897Trehalose-6-phosphate phosphatase, biosynthetic; Removes the phosphate from trehalose 6-phosphate (Tre6P) to produce free trehalose. Also catalyzes the dephosphorylation of glucose-6-phosphate (G [...]
araG protein networkhttps://string-db.org/network/511145.b1900L-arabinose ABC transporter ATPase; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system (Probable); Belongs to the ABC [...]
araF protein networkhttps://string-db.org/network/511145.b1901L-arabinose ABC transporter periplasmic binding protein; Involved in the high-affinity L-arabinose membrane transport system. Binds with high affinity to arabinose, but can also bind D- galactose [...]
ftnB protein networkhttps://string-db.org/network/511145.b1902Ferritin B, putative ferrous iron reservoir; Ferritin-like protein; Protein involved in iron ion transport.
yecR protein networkhttps://string-db.org/network/511145.b1904Lipoprotein, function unknown.
ftnA protein networkhttps://string-db.org/network/511145.b1905Ferritin iron storage protein (cytoplasmic); Iron-storage protein; Belongs to the ferritin family. Prokaryotic subfamily.
yecH protein networkhttps://string-db.org/network/511145.b1906DUF2492 family protein.
tyrP protein networkhttps://string-db.org/network/511145.b1907Tyrosine transporter; Involved in transporting tyrosine across the cytoplasmic membrane.
yecA protein networkhttps://string-db.org/network/511145.b1908UPF0149 family protein.
pgsA protein networkhttps://string-db.org/network/511145.b1912Phosphatidylglycerophosphate synthetase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
uvrC protein networkhttps://string-db.org/network/511145.b1913Excinuclease UvrABC, endonuclease subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal ha [...]
uvrY protein networkhttps://string-db.org/network/511145.b1914Response regulator in two-component regulatory system with BarA; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulato [...]
yecF protein networkhttps://string-db.org/network/511145.b1915DUF2594 family protein.
sdiA protein networkhttps://string-db.org/network/511145.b1916Quorum-sensing transcriptional activator; Activates cell division by specifically increasing transcription from one of the two promoters that lie immediately upstream of the ftsQAZ gene cluster. [...]
yecC protein networkhttps://string-db.org/network/511145.b1917Putative ABC transporter ATPase; Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L- cysteine, and it mediates accumulati [...]
yecS protein networkhttps://string-db.org/network/511145.b1918ABC family putative inner membrane permease; Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L- cysteine, and it mediate [...]
dcyD protein networkhttps://string-db.org/network/511145.b1919D-cysteine desulfhydrase, PLP-dependent; Catalyzes the alpha,beta-elimination reaction of D-cysteine and of several D-cysteine derivatives. It could be a defense mechanism against D-cysteine. Can [...]
fliY protein networkhttps://string-db.org/network/511145.b1920Cystine transporter subunit; Part of the ABC transporter complex FliY-YecC-YecS involved in L-cystine transport. The system can probably also transport L- cysteine, and it mediates accumulation o [...]
fliZ protein networkhttps://string-db.org/network/511145.b1921RpoS antagonist; During the post-exponential growth phase transiently interferes with RpoS (sigma S) activity without affecting expression of RpoS itself. It is probably not an anti-sigma factor [...]
fliA protein networkhttps://string-db.org/network/511145.b1922RNA polymerase, sigma 28 (sigma F) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor [...]
fliC protein networkhttps://string-db.org/network/511145.b1923Flagellar filament structural protein (flagellin); Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
fliD protein networkhttps://string-db.org/network/511145.b1924Flagellar filament capping protein; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing [...]
fliS protein networkhttps://string-db.org/network/511145.b1925Flagellar biosynthesis; repressor of class 3a and 3b operons (RflA activity); Protein involved in flagellum assembly and taxis.
fliT protein networkhttps://string-db.org/network/511145.b1926Putative flagellar synthesis and assembly chaperone; Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament [...]
amyA protein networkhttps://string-db.org/network/511145.b1927Cytoplasmic alpha-amylase; Protein involved in carbohydrate catabolic process and polysaccharide catabolic process; Belongs to the glycosyl hydrolase 13 family.
yedD protein networkhttps://string-db.org/network/511145.b1928Lipoprotein.
yedE protein networkhttps://string-db.org/network/511145.b1929UPF0394 family sulphur transport domain-containing inner membrane protein; Putative transport system permease protein; Belongs to the UPF0394 family.
yedF protein networkhttps://string-db.org/network/511145.b1930Putative TusA family sulfurtransferase; Belongs to the sulfur carrier protein TusA family.
yedK protein networkhttps://string-db.org/network/511145.b1931DUF159 family protein; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Recognizes and binds abasic site [...]
yedL protein networkhttps://string-db.org/network/511145.b1932GNAT family putative N-acetyltransferase; Belongs to the acetyltransferase family.
fliE protein networkhttps://string-db.org/network/511145.b1937Flagellar hook-basal body complex protein FliE; Pseudogene, phage integrase family.
fliF protein networkhttps://string-db.org/network/511145.b1938Flagellar basal-body MS-ring and collar protein; The M ring may be actively involved in energy transduction; Belongs to the FliF family.
fliG protein networkhttps://string-db.org/network/511145.b1939Flagellar motor switching and energizing component; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. T [...]
fliH protein networkhttps://string-db.org/network/511145.b1940Negative regulator of FliI ATPase activity; Needed for flagellar regrowth and assembly; Belongs to the FliH family.
fliI protein networkhttps://string-db.org/network/511145.b1941Flagellum-specific ATP synthase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be inv [...]
fliJ protein networkhttps://string-db.org/network/511145.b1942Flagellar protein; The FliJ protein is a flagellar protein that affects chemotactic events. Mutations in FliJ results in failure to respond to chemotactic stimuli.
fliK protein networkhttps://string-db.org/network/511145.b1943Flagellar hook-length control protein; Controls the length of the flagellar hook; Belongs to the FliK family.
fliL protein networkhttps://string-db.org/network/511145.b1944Flagellar biosynthesis protein; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.
fliM protein networkhttps://string-db.org/network/511145.b1945Flagellar motor switching and energizing component; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. T [...]
fliN protein networkhttps://string-db.org/network/511145.b1946Flagellar motor switching and energizing component; FliN is one of three proteins (FliG, FliN, FliM) that form a switch complex that is proposed to be located at the base of the basal body. This [...]
fliO protein networkhttps://string-db.org/network/511145.b1947Flagellar biosynthesis; Protein involved in flagellum assembly and taxis.
fliP protein networkhttps://string-db.org/network/511145.b1948Flagellar biosynthesis protein; Plays a role in the flagellum-specific transport system; Belongs to the FliP/MopC/SpaP family.
fliQ protein networkhttps://string-db.org/network/511145.b1949Flagellar biosynthesis protein; Required for the assembly of the rivet at the earliest stage of flagellar biosynthesis; Belongs to the FliQ/MopD/SpaQ family.
fliR protein networkhttps://string-db.org/network/511145.b1950Flagellar export pore protein; Role in flagellar biosynthesis; Belongs to the FliR/MopE/SpaR family.
rcsA protein networkhttps://string-db.org/network/511145.b1951Transcriptional regulator of colanic acid capsular biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds, with RcsB, to the RcsAB box to regul [...]
dsrB protein networkhttps://string-db.org/network/511145.b1952Uncharacterized protein.
yodD protein networkhttps://string-db.org/network/511145.b1953Uncharacterized protein.
yedP protein networkhttps://string-db.org/network/511145.b1955Putative mannosyl-3-phosphoglycerate phosphatase.
yedQ protein networkhttps://string-db.org/network/511145.b1956Putative membrane-anchored diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger wh [...]
yodC protein networkhttps://string-db.org/network/511145.b1957Uncharacterized protein.
yedI protein networkhttps://string-db.org/network/511145.b1958DUF808 family inner membrane protein.
yedA protein networkhttps://string-db.org/network/511145.b1959Amino acid exporter for phenylalanine, threonine; Putative transmembrane subunit.
vsr protein networkhttps://string-db.org/network/511145.b1960DNA mismatch endonuclease of very short patch repair; Deamination of 5-methylcytosine in DNA results in T/G mismatches. If unrepaired, these mismatches can lead to C-to-C transition mutations. Th [...]
dcm protein networkhttps://string-db.org/network/511145.b1961DNA cytosine methyltransferase; This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands.
yedJ protein networkhttps://string-db.org/network/511145.b1962Putative HD superfamily phosphohydrolase.
yedR protein networkhttps://string-db.org/network/511145.b1963Inner membrane protein.
hchA protein networkhttps://string-db.org/network/511145.b1967Protein/nucleic acid deglycase 1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbo [...]
yedV protein networkhttps://string-db.org/network/511145.b1968Putative sensory kinase in two-component regulatory system with YedW; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Senses H(2)O(2), maybe via t [...]
yedW protein networkhttps://string-db.org/network/511145.b1969Response regulator family protein; Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide. Regulates the expression of at least 5 operons, cyoABCDE, hprRS [...]
hiuH protein networkhttps://string-db.org/network/511145.b1970Hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
yedY protein networkhttps://string-db.org/network/511145.b1971Membrane-anchored, periplasmic TMAO, DMSO reductase; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain [...]
yedZ protein networkhttps://string-db.org/network/511145.b1972Inner membrane heme subunit for periplasmic YedYZ reductase; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respirator [...]
zinT protein networkhttps://string-db.org/network/511145.b1973Zinc and cadmium binding protein, periplasmic; May function as a periplasmic zinc chaperone or mediate direct transport of zinc from the periplasm to the cytoplasm under zinc-limited conditions. [...]
yodB protein networkhttps://string-db.org/network/511145.b1974Cytochrome b561 homolog 1; Protein involved in cytochrome complex assembly.
mtfA protein networkhttps://string-db.org/network/511145.b1976Anti-repressor for DgsA(Mlc); Involved in the regulation of ptsG expression by binding and inactivating Mlc; Belongs to the MtfA family.
yeeJ protein networkhttps://string-db.org/network/511145.b1978Putative factor; Protein involved in regulation of transcription, DNA-dependent; Belongs to the intimin/invasin family.
shiA protein networkhttps://string-db.org/network/511145.b1981Shikimate transporter; Pseudogene, glycosyltransferase homology.
amn protein networkhttps://string-db.org/network/511145.b1982AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.
yeeN protein networkhttps://string-db.org/network/511145.b1983UPF0082 family protein; Belongs to the TACO1 family. YeeN subfamily.
yeeO protein networkhttps://string-db.org/network/511145.b1985Putative multdrug exporter, MATE family; A transporter able to export peptides and flavins. When overexpressed allows cells deleted for multiple peptidases (pepA, pepB, pepD and pepN) to grow in [...]
cbl protein networkhttps://string-db.org/network/511145.b1987ssuEADCB/tauABCD operon transcriptional activator; May be an accessory regulatory protein within the cys regulon.
nac protein networkhttps://string-db.org/network/511145.b1988Nitrogen assimilation regulon transcriptional regulator; Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. [...]
ldtA protein networkhttps://string-db.org/network/511145.b1990L,D-transpeptidase linking Lpp to murein; Responsible, at least in part, for anchoring of the major outer membrane lipoprotein (Lpp, also known as the Braun lipoprotein) to the peptidoglycan via [...]
cobT protein networkhttps://string-db.org/network/511145.b1991Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole [...]
cobS protein networkhttps://string-db.org/network/511145.b1992Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and [...]
cobU protein networkhttps://string-db.org/network/511145.b1993Cobinamide kinase and cobinamide phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. Belongs to the C [...]
insH1-6 protein networkhttps://string-db.org/network/511145.b1994Transposase InsH for insertion sequence element IS5H; Involved in the transposition of the insertion sequence IS5.
insD1-3 protein networkhttps://string-db.org/network/511145.b1996CP4-44 prophage; putative disrupted hemin or colicin receptor;Phage or Prophage Related; interrupted by IS2 and C-terminal deletion.
insC1-3 protein networkhttps://string-db.org/network/511145.b1997IS2 repressor TnpA.
flu protein networkhttps://string-db.org/network/511145.b2000Novel sRNA, CP4-44; Controls colony form variation and autoaggregation. May function as an adhesin.
yeeR protein networkhttps://string-db.org/network/511145.b2001CP4-44 prophage; putative membrane protein.
yeeS protein networkhttps://string-db.org/network/511145.b2002CP4-44 prophage; Putative DNA repair protein, RADC family; Belongs to the UPF0758 family.
yeeT protein networkhttps://string-db.org/network/511145.b2003CP4-44 prophage; uncharacterized protein; Belongs to the YeeT/YkfH/YpjJ family.
cbeA protein networkhttps://string-db.org/network/511145.b2004CP4-44 prophage; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of its cognate toxin CbtA (YeeV). It does not bind to the toxin but instead bi [...]
cbtA protein networkhttps://string-db.org/network/511145.b2005CP4-44 prophage; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with [...]
yeeX protein networkhttps://string-db.org/network/511145.b2007UPF0265 protein YeeX; Pseudogene, CP4-44 putative prophage remnant;Phage or Prophage Related; Belongs to the UPF0265 family.
yeeA protein networkhttps://string-db.org/network/511145.b2008Putative transporter, FUSC family inner membrane protein.
sbmC protein networkhttps://string-db.org/network/511145.b2009DNA gyrase inhibitor; Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cell [...]
dacD protein networkhttps://string-db.org/network/511145.b2010D-alanyl-D-alanine carboxypeptidase; Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family.
sbcB protein networkhttps://string-db.org/network/511145.b2011Exodeoxyribonuclease I; Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties followi [...]
yeeD protein networkhttps://string-db.org/network/511145.b2012Putative TusA family sulfurtransferase.
yeeE protein networkhttps://string-db.org/network/511145.b2013UPF0394 family inner membrane protein; Putative transport system permease protein.
plaP protein networkhttps://string-db.org/network/511145.b2014Putrescine importer, low affinity; Putrescine importer. Required for induction of type 1 pili- driven surface motility.
yeeY protein networkhttps://string-db.org/network/511145.b2015Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yeeZ protein networkhttps://string-db.org/network/511145.b2016Putative enzyme of sugar metabolism; Protein involved in carbohydrate catabolic process.
yefM protein networkhttps://string-db.org/network/511145.b2017Antitoxin of the YoeB-YefM toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of the YoeB toxin. YefM binds to the promote [...]
hisL protein networkhttps://string-db.org/network/511145.b2018His operon leader peptide; Protein involved in histidine biosynthetic process.
hisG protein networkhttps://string-db.org/network/511145.b2019ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate [...]
hisD protein networkhttps://string-db.org/network/511145.b2020Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
hisC protein networkhttps://string-db.org/network/511145.b2021Histidinol-phosphate aminotransferase; Protein involved in histidine biosynthetic process; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate amin [...]
hisB protein networkhttps://string-db.org/network/511145.b2022Imidazoleglycerolphosphate dehydratase and histidinol-phosphate phosphatase; Protein involved in histidine biosynthetic process.
hisH protein networkhttps://string-db.org/network/511145.b2023Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydroly [...]
hisA protein networkhttps://string-db.org/network/511145.b2024N-(5'-phospho-L-ribosyl-formimino)-5-amino-1- (5'-phosphoribosyl)-4-imidazolecarboxamide isomerase; Protein involved in histidine biosynthetic process; Belongs to the HisA/HisF family.
hisF protein networkhttps://string-db.org/network/511145.b2025Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization ac [...]
hisI protein networkhttps://string-db.org/network/511145.b2026Phosphoribosyl-amp cyclohydrolase; phosphoribosyl-ATP pyrophosphatase; Protein involved in histidine biosynthetic process; In the C-terminal section; belongs to the PRA-PH family.
wzzB protein networkhttps://string-db.org/network/511145.b2027Regulator of length of O-antigen component of lipopolysaccharide chains; Confers a modal distribution of chain length on the O-antigen component of lipopolysaccharide (LPS). Gives rise to a reduc [...]
ugd protein networkhttps://string-db.org/network/511145.b2028UDP-glucose 6-dehydrogenase; Protein involved in cell surface antigen activity, host-interacting, colanic acid biosynthetic process and response to desiccation.
gnd protein networkhttps://string-db.org/network/511145.b20296-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
insH1-7 protein networkhttps://string-db.org/network/511145.b2030Pseudogene, lipopolysaccharide biosynthesis protein.
wbbK protein networkhttps://string-db.org/network/511145.b2032Lipopolysaccharide biosynthesis protein; May be a glycosyltransferase involved in the transfer of UDP- GalF and UDP-glucose.
wbbJ protein networkhttps://string-db.org/network/511145.b2033Putative lipopolysaccharide biosynthesis O-acetyl transferase; Putative O-acetyltransferase that transfers an O-acetyl group to the O antigen; Belongs to the transferase hexapeptide repeat family [...]
wbbI protein networkhttps://string-db.org/network/511145.b2034d-Galf:alpha-d-Glc beta-1,6-galactofuranosyltransferase; Involved in the transfer of galactofuranose (Galf) onto an alpha-D-gluco-configured acceptor substrate to form a beta-1,6-linkage. It uses [...]
wbbH protein networkhttps://string-db.org/network/511145.b2035O-antigen polymerase; May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS.
glf protein networkhttps://string-db.org/network/511145.b2036UDP-galactopyranose mutase, FAD/NAD(P)-binding; Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (U [...]
wzxB protein networkhttps://string-db.org/network/511145.b2037Putative polisoprenol-linked O-antigen transporter; May be involved in the translocation process of the nascent O-polysaccharide molecules and/or its ligation to lipid A core units.
rfbC protein networkhttps://string-db.org/network/511145.b2038dTDP-4-deoxyrhamnose-3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydr [...]
rfbA protein networkhttps://string-db.org/network/511145.b2039Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymid [...]
rfbD protein networkhttps://string-db.org/network/511145.b2040dTDP-L-rhamnose synthase, NAD(P)-dependent dTDP-4-dehydrorhamnose reductase subunit; Involved in the biosynthesis of the dTDP-L-rhamnose which is an important component of lipopolysaccharide (LPS [...]
rfbB protein networkhttps://string-db.org/network/511145.b2041dTDP-glucose 4,6 dehydratase, NAD(P)-binding; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and red [...]
wcaN protein networkhttps://string-db.org/network/511145.b2042Putative regulatory subunit for GalU; Protein involved in nucleotide-sugar biosynthetic process.
wcaM protein networkhttps://string-db.org/network/511145.b2043Putative colanic acid biosynthesis protein; Protein involved in colanic acid biosynthetic process.
wcaL protein networkhttps://string-db.org/network/511145.b2044Putative colanic acid biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process.
wcaK protein networkhttps://string-db.org/network/511145.b2045Putative galactokinase; Protein involved in colanic acid biosynthetic process.
wzxC protein networkhttps://string-db.org/network/511145.b2046Putative colanic acid exporter; Probable export protein; Belongs to the polysaccharide synthase family.
wcaJ protein networkhttps://string-db.org/network/511145.b2047Colanic biosynthesis UDP-glucose lipid carrier transferase; Is the initiating enzyme for colanic acid (CA) synthesis. Catalyzes the transfer of the glucose-1-phosphate moiety from UDP-Glc onto th [...]
cpsG protein networkhttps://string-db.org/network/511145.b2048Phosphomannomutase; Involved in the biosynthesis of the capsular polysaccharide colanic acid; Belongs to the phosphohexose mutase family.
cpsB protein networkhttps://string-db.org/network/511145.b2049Mannose-1-phosphate guanyltransferase; Involved in the biosynthesis of the capsular polysaccharide colanic acid.
wcaI protein networkhttps://string-db.org/network/511145.b2050Putative colanic biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process.
wcaH protein networkhttps://string-db.org/network/511145.b2051GDP-mannose mannosyl hydrolase; Hydrolyzes both GDP-mannose and GDP-glucose. Could participate in the regulation of cell wall biosynthesis by influencing the concentration of GDP-mannose or GDP-g [...]
wcaG protein networkhttps://string-db.org/network/511145.b2052GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Belongs to the NAD(P)-d [...]
gmd protein networkhttps://string-db.org/network/511145.b2053GDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose [...]
wcaF protein networkhttps://string-db.org/network/511145.b2054Putative transferase; Protein involved in colanic acid biosynthetic process.
wcaE protein networkhttps://string-db.org/network/511145.b2055Putative colanic acid biosynthesis glycosyl transferase; Protein involved in colanic acid biosynthetic process.
wcaD protein networkhttps://string-db.org/network/511145.b2056Putative colanic acid polymerase.
wcaC protein networkhttps://string-db.org/network/511145.b2057Putative glycosyl transferase; Protein involved in colanic acid biosynthetic process.
wcaB protein networkhttps://string-db.org/network/511145.b2058Putative transferase; Protein involved in colanic acid biosynthetic process.
wcaA protein networkhttps://string-db.org/network/511145.b2059Putative glycosyl transferase; Putative regulator; Protein involved in colanic acid biosynthetic process.
wzc protein networkhttps://string-db.org/network/511145.b2060Colanic acid production tyrosine-protein kinase; Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of [...]
wzb protein networkhttps://string-db.org/network/511145.b2061Colanic acid production protein-tyrosine-phosphatase; Dephosphorylates Wzc. Required for the extracellular polysaccharide colanic acid synthesis, probably involved in the export of colanic acid f [...]
wza protein networkhttps://string-db.org/network/511145.b2062Colanic acid export protein; Probably involved in the export of the extracellular polysaccharide colanic acid from the cell to medium.
yegH protein networkhttps://string-db.org/network/511145.b2063Inner membrane protein; Putative transport protein.
asmA protein networkhttps://string-db.org/network/511145.b2064Suppressor of OmpF assembly mutants; Involved in the inhibition of assembly of mutant ompF proteins. In general, could be involved in the assembly of outer membrane proteins; Belongs to the AsmA [...]
dcd protein networkhttps://string-db.org/network/511145.b2065Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP.
udk protein networkhttps://string-db.org/network/511145.b2066Uridine/cytidine kinase; Protein involved in nucleobase, nucleoside and nucleotide interconversion; Belongs to the uridine kinase family.
yegE protein networkhttps://string-db.org/network/511145.b2067Putative diguanylate cyclase; Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Involved in the control of the switch from cell motility [...]
alkA protein networkhttps://string-db.org/network/511145.b20683-methyl-adenine DNA glycosylase II; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, 3-methylguanine, 7-methylguanine, O2-methylthymine, and O2-methylcytosine from the [...]
yegD protein networkhttps://string-db.org/network/511145.b2069Hsp70 chaperone family protein; Putative heat shock protein; Protein involved in protein folding; Belongs to the heat shock protein 70 family.
yegI protein networkhttps://string-db.org/network/511145.b2070Protein kinase-related putative non-specific DNA-binding protein; Probable serine/threonine kinase.
yegJ protein networkhttps://string-db.org/network/511145.b2071Uncharacterized protein.
yegK protein networkhttps://string-db.org/network/511145.b2072Ser/thr phosphatase-related protein; PP2C-like phosphatase that can dephosphorylate YegI. In vitro, can hydrolyze p-nitrophenyl phosphate (pNPP) to p-nitrophenol.
yegL protein networkhttps://string-db.org/network/511145.b2073VMA domain protein.
mdtA protein networkhttps://string-db.org/network/511145.b2074Multidrug efflux system, subunit A; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Belongs to the membrane fusion pro [...]
mdtB protein networkhttps://string-db.org/network/511145.b2075Multidrug efflux system, subunit B; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
mdtC protein networkhttps://string-db.org/network/511145.b2076Multidrug efflux system, subunit C; The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function.
iceT protein networkhttps://string-db.org/network/511145.b2077Putative citrate/iron-citrate/zinc-citrate efflux transporter; Putative transport protein; Belongs to the major facilitator superfamily. TCR/Tet family.
baeS protein networkhttps://string-db.org/network/511145.b2078Sensory histidine kinase in two-component regulatory system with BaeR; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasm [...]
baeR protein networkhttps://string-db.org/network/511145.b2079Response regulator in two-component regulatory system with BaeS; Member of the two-component regulatory system BaeS/BaeR which responds to envelope stress. Activates expression of periplasmic cha [...]
yegP protein networkhttps://string-db.org/network/511145.b2080UPF0339 family protein; Belongs to the UPF0339 family. Duplicated subfamily.
yegQ protein networkhttps://string-db.org/network/511145.b2081Putative peptidase; Belongs to the peptidase U32 family.
ogrK protein networkhttps://string-db.org/network/511145.b2082Orphan Ogr protein, positive regulator of P2 growth; Cryptic version of the phage P2 OGR protein which acts as an activator of P2 late transcription.
yegR protein networkhttps://string-db.org/network/511145.b2085Uncharacterized protein YegR; Pseudogene, gpD phage P2-like protein D.
yegS protein networkhttps://string-db.org/network/511145.b2086Phosphatidylglycerol kinase, metal-dependent; In vitro phosphorylates phosphatidylglycerol but not diacylglycerol; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase fam [...]
insE1-5 protein networkhttps://string-db.org/network/511145.b2088Pseudogene, repressor for gat operon; interrupted by IS3; split galactitol utilization operon repressor, fragment 2; split galactitol utilization operon repressor, interrupted.
insF1-5 protein networkhttps://string-db.org/network/511145.b2089IS3 transposase B.
gatD protein networkhttps://string-db.org/network/511145.b2091Galactitol-1-phosphate dehydrogenase, Zn-dependent and NAD(P)-binding; Converts galactitol 1-phosphate to D-tagatose 6-phosphate. Belongs to the zinc-containing alcohol dehydrogenase family.
gatB protein networkhttps://string-db.org/network/511145.b2093PTS system galactitol-specific EIIB component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation [...]
gatA protein networkhttps://string-db.org/network/511145.b2094Galactitol-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylati [...]
gatZ protein networkhttps://string-db.org/network/511145.b2095D-tagatose 1,6-bisphosphate aldolase 2, subunit; Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperon [...]
gatY protein networkhttps://string-db.org/network/511145.b2096D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone [...]
fbaB protein networkhttps://string-db.org/network/511145.b2097Fructose-bisphosphate aldolase class I; Protein involved in glycolysis; Belongs to the DeoC/FbaB aldolase family. FbaB subfamily.
yegT protein networkhttps://string-db.org/network/511145.b2098Nucleoside transporter, low affinity; Could be involved in nucleoside transport; Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family.
yegU protein networkhttps://string-db.org/network/511145.b2099ADP-ribosylglycohydrolase family protein; Belongs to the ADP-ribosylglycohydrolase family.
yegV protein networkhttps://string-db.org/network/511145.b2100Putative kinase; Belongs to the carbohydrate kinase PfkB family.
yegW protein networkhttps://string-db.org/network/511145.b2101Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription.
yegX protein networkhttps://string-db.org/network/511145.b2102Putative family 25 glycosyl hydrolase; Belongs to the glycosyl hydrolase 25 family.
thiD protein networkhttps://string-db.org/network/511145.b2103Hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no act [...]
thiM protein networkhttps://string-db.org/network/511145.b2104Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
rcnR protein networkhttps://string-db.org/network/511145.b2105Transcriptional repressor of rcnA; Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it [...]
rcnA protein networkhttps://string-db.org/network/511145.b2106Membrane protein conferring nickel and cobalt resistance; Efflux system for nickel and cobalt.
rcnB protein networkhttps://string-db.org/network/511145.b2107Periplasmic modulator of Ni and Co efflux; Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import [...]
yehA protein networkhttps://string-db.org/network/511145.b2108Putative fimbrial-like adhesin protein; Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yehB protein networkhttps://string-db.org/network/511145.b2109Putative outer membrane protein; Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Probably involved in the export and assemb [...]
yehC protein networkhttps://string-db.org/network/511145.b2110Putative periplasmic pilin chaperone; Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yehD protein networkhttps://string-db.org/network/511145.b2111Putative fimbrial-like adhesin protein; Part of the yehABCD fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches.
yehE protein networkhttps://string-db.org/network/511145.b2112DUF2574 family protein.
mrp protein networkhttps://string-db.org/network/511145.b2113Antiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
metG protein networkhttps://string-db.org/network/511145.b2114methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the [...]
yehI protein networkhttps://string-db.org/network/511145.b2118Uncharacterized protein YehI; DUF4132 family pseudogene; defective yehI paralog; molybdate metabolism regulator, first fragment; molybdate metabolism regulator, second fragment 2; yehI' molR muta [...]
yehL protein networkhttps://string-db.org/network/511145.b2119Putative hexameric AAA+ MoxR family ATPase; Protein involved in ATP-binding cassette (ABC) transporter activity.
yehM protein networkhttps://string-db.org/network/511145.b2120Uncharacterized protein.
yehP protein networkhttps://string-db.org/network/511145.b2121VMA domain putative YehL ATPase stimulator.
yehR protein networkhttps://string-db.org/network/511145.b2123Uncharacterized lipoprotein YehR; Pseudogene.
yehS protein networkhttps://string-db.org/network/511145.b2124DUF1456 family protein.
yehT protein networkhttps://string-db.org/network/511145.b2125Putative response regulator in two-component system withYehU; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed of BtsS/BtsR [...]
yehU protein networkhttps://string-db.org/network/511145.b2126Inner membrane putative sensory kinase in two-component system with YehT; Member of the two-component regulatory system BtsS/BtsR, which is part of a nutrient-sensing regulatory network composed [...]
mlrA protein networkhttps://string-db.org/network/511145.b2127Transcriptional activator of csgD and csgBA; Activates transcription of csgD, the master regulator of biofilm formation, by binding to its promoter region. Also controls the transcription of cadC [...]
yehW protein networkhttps://string-db.org/network/511145.b2128Putative ABC transporter permease; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membr [...]
yehX protein networkhttps://string-db.org/network/511145.b2129Putative ABC transporter ATPase; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for energy coupling to the transport system.
yehY protein networkhttps://string-db.org/network/511145.b2130Putative ABC transporter permease; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membr [...]
osmF protein networkhttps://string-db.org/network/511145.b2131Putative ABC transporter periplasmic binding protein; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Binds glycine betaine with low affinity. Belongs to the O [...]
bglX protein networkhttps://string-db.org/network/511145.b2132beta-D-glucoside glucohydrolase, periplasmic; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 3 family.
dld protein networkhttps://string-db.org/network/511145.b2133D-lactate dehydrogenase, FAD-binding, NADH independent; Catalyzes the oxidation of D-lactate to pyruvate. Electrons derived from D-lactate oxidation are transferred to the ubiquinone/cytochrome e [...]
pbpG protein networkhttps://string-db.org/network/511145.b2134D-alanyl-D-alanine endopeptidase; Cell wall formation. May play a specialized role in remodeling the cell wall. Specifically hydrolyzes the DD- diaminopimelate-alanine bonds in high-molecular-mas [...]
yohC protein networkhttps://string-db.org/network/511145.b2135Yip1 family inner membrane protein.
yohD protein networkhttps://string-db.org/network/511145.b2136DedA family inner membrane protein.
yohF protein networkhttps://string-db.org/network/511145.b2137Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
dusC protein networkhttps://string-db.org/network/511145.b2140tRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines [...]
yohJ protein networkhttps://string-db.org/network/511145.b2141UPF0299 family inner membrane protein.
yohK protein networkhttps://string-db.org/network/511145.b2142LrgB family inner membrane protein; Putative seritonin transporter.
cdd protein networkhttps://string-db.org/network/511145.b2143Cytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
sanA protein networkhttps://string-db.org/network/511145.b2144DUF218 superfamily vancomycin high temperature exclusion protein; Participates in the barrier function of the cell envelope.
yeiS protein networkhttps://string-db.org/network/511145.b2145DUF2542 family protein.
preT protein networkhttps://string-db.org/network/511145.b2146Dihydropyrimidine dehydrogenase, NADH-dependent, subunit N; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as [...]
preA protein networkhttps://string-db.org/network/511145.b2147Dihydropyrimidine dehydrogenase, NADH-dependent, subunit C; Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as [...]
mglC protein networkhttps://string-db.org/network/511145.b2148Methyl-galactoside transporter subunit; Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane.
mglA protein networkhttps://string-db.org/network/511145.b2149Methyl-galactoside ABC transporter ATPase; Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system (Pro [...]
mglB protein networkhttps://string-db.org/network/511145.b2150Methyl-galactoside transporter subunit; This protein is involved in the active transport of galactose and glucose. It plays a role in the chemotaxis towards the two sugars by interacting with the [...]
galS protein networkhttps://string-db.org/network/511145.b2151Galactose- and fucose-inducible galactose regulon transcriptional isorepressor; Repressor of the mgl operon. Binds galactose and D-fucose as inducers. GalS binds to an operator DNA sequence withi [...]
yeiB protein networkhttps://string-db.org/network/511145.b2152DUF418 family putative inner membrane protein; Involved in transport; To B.subtilis YxaH and YrkO.
folE protein networkhttps://string-db.org/network/511145.b2153GTP cyclohydrolase I; Protein involved in folic acid biosynthetic process; Belongs to the GTP cyclohydrolase I family.
yeiG protein networkhttps://string-db.org/network/511145.b2154S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alp [...]
cirA protein networkhttps://string-db.org/network/511145.b2155Colicin IA outer membrane receptor and translocator; Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.
lysP protein networkhttps://string-db.org/network/511145.b2156Lysine transporter; Permease that is involved in the transport across the cytoplasmic membrane of lysine; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporte [...]
yeiE protein networkhttps://string-db.org/network/511145.b2157Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yeiH protein networkhttps://string-db.org/network/511145.b2158UPF0324 family inner membrane protein.
nfo protein networkhttps://string-db.org/network/511145.b2159Endonuclease IV with intrinsic 3'-5' exonuclease activity; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydr [...]
yeiI protein networkhttps://string-db.org/network/511145.b2160Putative kinase; Belongs to the carbohydrate kinase PfkB family.
nupX protein networkhttps://string-db.org/network/511145.b2161Putative pyrimidine nucleoside transporter.
rihB protein networkhttps://string-db.org/network/511145.b2162Ribonucleoside hydrolase 2; Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively. Has a clear preference for cytidine over uridine. Strictly specific for ribonucleosides. [...]
yeiL protein networkhttps://string-db.org/network/511145.b2163Putative transcriptional regulator; Transcription regulator involved in mid-term, stationary- phase viability under nitrogen starvation. Might control expression of the salvage pathways or in som [...]
psuT protein networkhttps://string-db.org/network/511145.b2164Putative nucleoside transporter; Could be involved in pseudouridine transport; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
psuG protein networkhttps://string-db.org/network/511145.b2165Pseudouridine 5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction [...]
psuK protein networkhttps://string-db.org/network/511145.b2166Pseudouridine kinase; Catalyzes the phosphorylation of pseudouridine to pseudouridine 5'-phosphate (PsiMP).
fruA protein networkhttps://string-db.org/network/511145.b2167Fused fructose-specific PTS enzymes: IIBcomponent/IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, cata [...]
fruK protein networkhttps://string-db.org/network/511145.b2168Fructose-1-phosphate kinase; Protein involved in glycolysis; Belongs to the carbohydrate kinase PfkB family.
fruB protein networkhttps://string-db.org/network/511145.b2169Fused fructose-specific PTS enzymes: IIA component/HPr component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, cata [...]
setB protein networkhttps://string-db.org/network/511145.b2170Lactose/glucose efflux system; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport lactose and glucose; Belongs to [...]
yeiP protein networkhttps://string-db.org/network/511145.b2171Putative elongation factor; Protein involved in translation.
yeiQ protein networkhttps://string-db.org/network/511145.b2172Putative oxidoreductase; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
yeiR protein networkhttps://string-db.org/network/511145.b2173Zn-stimulated GTPase involved in zinc homeostasis; Involved in metal homeostasis. Has GTPase activity. Binds several Zn(2+) ions in vitro.
lpxT protein networkhttps://string-db.org/network/511145.b2174Lipid A 1-diphosphate synthase; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to [...]
mepS protein networkhttps://string-db.org/network/511145.b2175Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase; A murein DD-endopeptidase with specificity for D-Ala-meso- diaminopimelic acid (mDAP) cross-links. Its role is probably to cleave D-Ala-mD [...]
rtn protein networkhttps://string-db.org/network/511145.b2176Probable cyclic di-GMP phosphodiesterase PdeN; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
yejA protein networkhttps://string-db.org/network/511145.b2177Periplasmic-binding component of ABC superfamily; To H.influenzae HbpA.
yejB protein networkhttps://string-db.org/network/511145.b2178Microcin C ABC transporter permease; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the [...]
yejE protein networkhttps://string-db.org/network/511145.b2179Microcin C ABC transporter permease; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the [...]
yejF protein networkhttps://string-db.org/network/511145.b2180Microcin C ABC transporter ATPase; Putative ATP-binding component of a transport system.
yejG protein networkhttps://string-db.org/network/511145.b2181Uncharacterized protein.
bcr protein networkhttps://string-db.org/network/511145.b2182Bicyclomycin/cysteine/sulfonamide efflux transporter; Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase. A transporter able to export peptides. Wh [...]
rsuA protein networkhttps://string-db.org/network/511145.b218316S rRNA pseudouridine(516) synthase; Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.
yejH protein networkhttps://string-db.org/network/511145.b2184Putative ATP-dependent DNA or RNA helicase; RadD contains helicase motifs, suggesting it may be a helicase, although that activity has not been observed (Probable). In combination with RadA is im [...]
rplY protein networkhttps://string-db.org/network/511145.b218550S ribosomal subunit protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Binds to the 5S rRNA independently of L5 a [...]
yejK protein networkhttps://string-db.org/network/511145.b2186Protein present in spermidine nucleoids.
yejL protein networkhttps://string-db.org/network/511145.b2187UPF0352 family protein; Belongs to the UPF0352 family.
yejM protein networkhttps://string-db.org/network/511145.b2188Essential inner membrane DUF3413 domain-containing protein; Putative sulfatase.
insH1-8 protein networkhttps://string-db.org/network/511145.b2192Pseudogene, autotransporter outer membrane homology;putative transport; Not classified; putative ATP-binding component of a transport system.
narP protein networkhttps://string-db.org/network/511145.b2193Response regulator in two-component regulatory system with NarQ; This protein activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons and represse [...]
ccmH protein networkhttps://string-db.org/network/511145.b2194Heme lyase, CcmH subunit; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
dsbE protein networkhttps://string-db.org/network/511145.b2195Periplasmic thioredoxin of cytochrome c-type biogenesis; Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the red [...]
ccmF protein networkhttps://string-db.org/network/511145.b2196Heme lyase, CcmF subunit; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
ccmE protein networkhttps://string-db.org/network/511145.b2197Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facil [...]
ccmD protein networkhttps://string-db.org/network/511145.b2198Cytochrome c biogenesis protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
ccmC protein networkhttps://string-db.org/network/511145.b2199Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
ccmB protein networkhttps://string-db.org/network/511145.b2200Heme export ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.
ccmA protein networkhttps://string-db.org/network/511145.b2201Heme export ABC transporter ATPase; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its [...]
napC protein networkhttps://string-db.org/network/511145.b2202Quinol dehydrogenase, electron source for NapAB; Mediates electron flow from quinones to the NapAB complex.
napB protein networkhttps://string-db.org/network/511145.b2203Nitrate reductase, small, cytochrome C550 subunit, periplasmic; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane-anchored tetrahe [...]
napH protein networkhttps://string-db.org/network/511145.b2204Ferredoxin-type protein; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
napG protein networkhttps://string-db.org/network/511145.b2205Ferredoxin-type protein; Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.
napA protein networkhttps://string-db.org/network/511145.b2206Nitrate reductase, periplasmic, large subunit; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite [...]
napD protein networkhttps://string-db.org/network/511145.b2207Assembly protein for periplasmic nitrate reductase; Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal [...]
napF protein networkhttps://string-db.org/network/511145.b2208Ferredoxin-type protein, role in electron transfer to periplasmic nitrate reductase NapA; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, [...]
eco protein networkhttps://string-db.org/network/511145.b2209Ecotin, a serine protease inhibitor; General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases. The [...]
mqo protein networkhttps://string-db.org/network/511145.b2210Malate dehydrogenase, FAD/NAD(P)-binding domain; Protein involved in tricarboxylic acid cycle.
yojI protein networkhttps://string-db.org/network/511145.b2211Microcin J25 efflux ABC transporter permease/ATPase; Mediates resistance to the antibacterial peptide microcin J25, when expressed from a multicopy vector. Functions as an efflux pump for microci [...]
alkB protein networkhttps://string-db.org/network/511145.b2212Oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions; Dioxygenase that repairs alkylated DNA and RNA containing 3- methylcytosine or 1-methyladenine by oxidative demethylati [...]
ada protein networkhttps://string-db.org/network/511145.b2213Fused DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Involved in the adaptive response to alkylation damage in DNA caused by alkylating agents. Repairs O6-meth [...]
apbE protein networkhttps://string-db.org/network/511145.b2214Putative thiamine-synthetic flavin transferase lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine r [...]
ompC protein networkhttps://string-db.org/network/511145.b2215Outer membrane porin protein C; Forms pores that allow passive diffusion of small molecules across the outer membrane. (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane r [...]
rcsD protein networkhttps://string-db.org/network/511145.b2216Phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfe [...]
rcsB protein networkhttps://string-db.org/network/511145.b2217Response regulator in two-component regulatory system with RcsC and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator tha [...]
rcsC protein networkhttps://string-db.org/network/511145.b2218Hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- a [...]
atoS protein networkhttps://string-db.org/network/511145.b2219Sensory histidine kinase in two-component regulatory system with AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expressio [...]
atoC protein networkhttps://string-db.org/network/511145.b2220Regulatory protein AtoC; Member of the two-component regulatory system AtoS/AtoC. In the presence of acetoacetate, AtoS/AtoC stimulates the expression of the atoDAEB operon, leading to short chai [...]
atoD protein networkhttps://string-db.org/network/511145.b2221acetyl-CoA:acetoacetyl-CoA transferase alpha subunit; Protein involved in fatty acid oxidation.
atoA protein networkhttps://string-db.org/network/511145.b2222acetyl-CoA:acetoacetyl-CoA transferase beta subunit; Protein involved in fatty acid oxidation; Belongs to the 3-oxoacid CoA-transferase subunit B family.
atoE protein networkhttps://string-db.org/network/511145.b2223Short chain fatty acid transporter; May be responsible for the uptake of short-chain fatty acids.
atoB protein networkhttps://string-db.org/network/511145.b2224acetyl-CoA acetyltransferase; Protein involved in fatty acid oxidation.
yfaP protein networkhttps://string-db.org/network/511145.b2225DUF2135 family protein, putative host defense protein.
yfaQ protein networkhttps://string-db.org/network/511145.b2226Tandem DUF2300 domain protein, putative host defense protein.
yfaT protein networkhttps://string-db.org/network/511145.b2229Uncharacterized protein YfaT; Pseudogene, bacterial alpha2-macroglobulin YfaS variant family; putative membrane protein; To P.aeruginosa PA4490 and T.maritima TM0986.
yfaA protein networkhttps://string-db.org/network/511145.b2230DUF2138 family protein, putative host defense protein.
gyrA protein networkhttps://string-db.org/network/511145.b2231DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an [...]
ubiG protein networkhttps://string-db.org/network/511145.b2232Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathw [...]
yfaL protein networkhttps://string-db.org/network/511145.b2233Adhesin; Probably an autotransporter.
nrdA protein networkhttps://string-db.org/network/511145.b2234Ribonucleoside-diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotid [...]
nrdB protein networkhttps://string-db.org/network/511145.b2235Ribonucleoside-diphosphate reductase 1, beta subunit, ferritin-like protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corre [...]
yfaE protein networkhttps://string-db.org/network/511145.b2236Uncharacterized ferredoxin-like protein YfaE; Ferredoxin involved with ribonucleotide reductase diferric-tyrosyl radical (Y*) cofactor maintenance.
inaA protein networkhttps://string-db.org/network/511145.b2237Acid-inducible Kdo/WaaP family putative kinase; May be an environmental sensor responsive to several stimuli, including internal pH, proton motive force, temperature, and possibly other unknown f [...]
glpQ protein networkhttps://string-db.org/network/511145.b2239Glycerophosphodiester phosphodiesterase, periplasmic; Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
glpT protein networkhttps://string-db.org/network/511145.b2240Sn-glycerol-3-phosphate transporter; Responsible for glycerol-3-phosphate uptake.
glpA protein networkhttps://string-db.org/network/511145.b2241Anaerobic sn-glycerol-3-phosphate dehydrogenase, large FAD/NAD(P)-binding subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.
glpB protein networkhttps://string-db.org/network/511145.b2242Anaerobic sn-glycerol-3-phosphate dehydrogenase membrane anchor subunit; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor; Belongs to the anae [...]
glpC protein networkhttps://string-db.org/network/511145.b2243Anaerobic sn-glycerol-3-phosphate dehydrogenase, C subunit, 4Fe-4S iron-sulfur cluster; Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer.
yfaD protein networkhttps://string-db.org/network/511145.b2244Transposase_31 family protein; Upon expression has no effect on RecA-independent DNA recombination, cell viability or DNA damage.
rhmA protein networkhttps://string-db.org/network/511145.b22452-keto-3-deoxy-L-rhamnonate aldolase; Catalyzes the reversible retro-aldol cleavage of 2-keto-3- deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde. 2-keto-3-deoxy- L-mannonate, 2-keto-3-deoxy [...]
rhmT protein networkhttps://string-db.org/network/511145.b2246Putative L-rhamnonate transporter; Putative transport protein; Belongs to the major facilitator superfamily. Phthalate permease family.
rhmD protein networkhttps://string-db.org/network/511145.b2247L-rhamnonate dehydratase; Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy- L-rhamnonate (KDR). Can also dehydrate L-lyxonate, L-mannonate and D- gulonate, although less efficiently, b [...]
rhmR protein networkhttps://string-db.org/network/511145.b2248Putative DNA-binding transcriptional regulator for the rhm operon; Putative regulator; Protein involved in transcription and regulation of transcription, DNA-dependent.
yfaY protein networkhttps://string-db.org/network/511145.b2249Inactive PncC family protein; Does not have nicotinamide-nucleotide (NMN) amidohydrolase activity.
yfaZ protein networkhttps://string-db.org/network/511145.b2250Outer membrane protein, putative porin.
nudI protein networkhttps://string-db.org/network/511145.b2251Nucleoside triphosphatase; Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP).
ais protein networkhttps://string-db.org/network/511145.b2252Putative LPS core heptose(II)-phosphate phosphatase; Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the phosphoglycerate mutase family. A [...]
arnB protein networkhttps://string-db.org/network/511145.b2253Uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase, PLP-dependent; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP- [...]
arnC protein networkhttps://string-db.org/network/511145.b2254Undecaprenyl phosphate-L-Ara4FN transferase; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is req [...]
arnA protein networkhttps://string-db.org/network/511145.b2255Fused UDP-L-Ara4N formyltransferase/UDP-GlcA C-4'-decarboxylase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP- [...]
arnD protein networkhttps://string-db.org/network/511145.b2256Undecaprenyl phosphate-alpha-L-ara4FN deformylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The mod [...]
arnT protein networkhttps://string-db.org/network/511145.b22574-amino-4-deoxy-L-arabinose transferase; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipi [...]
arnF protein networkhttps://string-db.org/network/511145.b2258Undecaprenyl phosphate-alpha-L-ara4N exporter; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the [...]
pmrD protein networkhttps://string-db.org/network/511145.b2259Inactive two-component system connector protein; Interacts with phosphorylated BasR protein to mediate transcriptional induction of BasR-activated genes to induce polymyxin resistance in some nat [...]
menE protein networkhttps://string-db.org/network/511145.b2260O-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
menC protein networkhttps://string-db.org/network/511145.b2261O-succinylbenzoyl-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
menB protein networkhttps://string-db.org/network/511145.b2262Dihydroxynaphthoic acid synthetase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
menH protein networkhttps://string-db.org/network/511145.b22632-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cy [...]
menD protein networkhttps://string-db.org/network/511145.b22642-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulti [...]
menF protein networkhttps://string-db.org/network/511145.b2265Isochorismate synthase 2; Catalyzes the conversion of chorismate to isochorismate. Can also catalyze the reverse reaction, but with a lower efficiency.
elaB protein networkhttps://string-db.org/network/511145.b2266Putative membrane-anchored DUF883 family ribosome-binding protein; Belongs to the ElaB/YgaM/YqjD family.
elaA protein networkhttps://string-db.org/network/511145.b2267GNAT family putative N-acetyltransferase; Belongs to the UPF0039 (ElaA) family.
rbn protein networkhttps://string-db.org/network/511145.b2268RNase BN, tRNA processing enzyme; Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities, depending on the nature of the substrate and of the added divalent cation [...]
elaD protein networkhttps://string-db.org/network/511145.b2269Protease, capable of cleaving an AMC-ubiquitin model substrate; Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylati [...]
yfbK protein networkhttps://string-db.org/network/511145.b2270Von Willebrand factor domain putative lipoprotein; To Synechocystis PCC 6803 sll0103.
yfbL protein networkhttps://string-db.org/network/511145.b2271Putative aminopeptidase.
yfbM protein networkhttps://string-db.org/network/511145.b2272DUF1877 family protein.
yfbN protein networkhttps://string-db.org/network/511145.b2273Uncharacterized protein.
yfbO protein networkhttps://string-db.org/network/511145.b2274Uncharacterized protein.
yfbP protein networkhttps://string-db.org/network/511145.b2275TPR-like repeats-containing protein.
nuoN protein networkhttps://string-db.org/network/511145.b2276NADH:ubiquinone oxidoreductase, membrane subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoM protein networkhttps://string-db.org/network/511145.b2277NADH:ubiquinone oxidoreductase, membrane subunit M; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoL protein networkhttps://string-db.org/network/511145.b2278NADH:ubiquinone oxidoreductase, membrane subunit L; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoK protein networkhttps://string-db.org/network/511145.b2279NADH:ubiquinone oxidoreductase, membrane subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoJ protein networkhttps://string-db.org/network/511145.b2280NADH:ubiquinone oxidoreductase, membrane subunit J; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoI protein networkhttps://string-db.org/network/511145.b2281NADH:ubiquinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the [...]
nuoH protein networkhttps://string-db.org/network/511145.b2282NADH:ubiquinone oxidoreductase, membrane subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
nuoG protein networkhttps://string-db.org/network/511145.b2283NADH:ubiquinone oxidoreductase, chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the [...]
nuoF protein networkhttps://string-db.org/network/511145.b2284NADH:ubiquinone oxidoreductase, chain F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the [...]
nuoE protein networkhttps://string-db.org/network/511145.b2285NADH:ubiquinone oxidoreductase, chain E; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the [...]
nuoC protein networkhttps://string-db.org/network/511145.b2286NADH:ubiquinone oxidoreductase, fused CD subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor [...]
nuoB protein networkhttps://string-db.org/network/511145.b2287NADH:ubiquinone oxidoreductase, chain B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the [...]
nuoA protein networkhttps://string-db.org/network/511145.b2288NADH:ubiquinone oxidoreductase, membrane subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron accept [...]
lrhA protein networkhttps://string-db.org/network/511145.b2289Transcriptional repressor of flagellar, motility and chemotaxis genes; Not known, does not seem to act on the proton translocating NADH dehydrogenase genes (nuoA-N) which are part of the lrhA ope [...]
alaA protein networkhttps://string-db.org/network/511145.b2290Glutamate-pyruvate aminotransferase; Involved in the biosynthesis of alanine.
yfbR protein networkhttps://string-db.org/network/511145.b22915'-nucleotidase; Essential component of the deoxycytidine triphosphate (dCTP) pathway for de novo synthesis of thymidylate. Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleo [...]
yfbS protein networkhttps://string-db.org/network/511145.b2292Putative transport protein.
yfbT protein networkhttps://string-db.org/network/511145.b2293Sugar phosphatas; Sugar-phosphate phosphohydrolase that appears to contribute to butanol tolerance. Catalyzes the dephosphorylation of D-mannitol 1-phosphate and D-sorbitol 6-phosphate. Is also a [...]
yfbU protein networkhttps://string-db.org/network/511145.b2294UPF0304 family protein.
yfbV protein networkhttps://string-db.org/network/511145.b2295UPF0208 family inner membrane protein.
ackA protein networkhttps://string-db.org/network/511145.b2296Acetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. During anaerobic growth of the organism, this e [...]
pta protein networkhttps://string-db.org/network/511145.b2297Phosphate acetyltransferase; Involved in acetate metabolism. Catalyzes the reversible interconversion of acetyl-CoA and acetyl phosphate. The direction of the overall reaction changes depending o [...]
yfcC protein networkhttps://string-db.org/network/511145.b2298Putative inner membrane transporter; Metabolomic profiling of different yfcC over-expression and deletion strains suggests that it may affect the glyoxylate shunt. To H.influenzae HI_0594.
yfcD protein networkhttps://string-db.org/network/511145.b2299Putative NUDIX hydrolase; Putative regulator; Belongs to the Nudix hydrolase family.
yfcE protein networkhttps://string-db.org/network/511145.b2300Phosphodiesterase activity on bis-pNPP; Shows phosphodiesterase activity, hydrolyzing phosphodiesters bonds in the artificial chromogenic substrates bis-p-nitrophenyl phosphate (bis-pNPP), and le [...]
yfcF protein networkhttps://string-db.org/network/511145.b2301Glutathione S-transferase; Exhibits glutathione (GSH) S-transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB); however this activity is as low as 1% of that of GstA. Also displays a GSH [...]
yfcG protein networkhttps://string-db.org/network/511145.b2302GSH-dependent disulfide bond oxidoreductase; Exhibits a very robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual [...]
folX protein networkhttps://string-db.org/network/511145.b2303D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase and dihydroneopterin aldolase; Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to [...]
yfcH protein networkhttps://string-db.org/network/511145.b2304Putative sugar nucleotide epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
yfcI protein networkhttps://string-db.org/network/511145.b2305Transposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends (Probable). Upon expression enhances RecA-independent DNA recombination 19-fold, concomitantly reducing vi [...]
hisP protein networkhttps://string-db.org/network/511145.b2306Histidine ABC transporter ATPase; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Responsible for energy coupling to the transport system (By [...]
hisM protein networkhttps://string-db.org/network/511145.b2307Histidine ABC transporter permease; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substra [...]
hisQ protein networkhttps://string-db.org/network/511145.b2308Histidine ABC transporter permease; Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substra [...]
hisJ protein networkhttps://string-db.org/network/511145.b2309Histidine ABC transporter periplasmic binding protein; Part of the histidine permease ABC transporter. Binds histidine. Interacts with HisQMP and stimulates ATPase activity of HisP, which results [...]
argT protein networkhttps://string-db.org/network/511145.b2310Lysine/arginine/ornithine transporter subunit; Part of an ABC transporter involved in lysine, arginine and ornithine transport. Stimulates ATPase activity of HisP (By similarity).
ubiX protein networkhttps://string-db.org/network/511145.b23113-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylas [...]
purF protein networkhttps://string-db.org/network/511145.b2312Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. Can also use NH(3) in place of glutamine.
cvpA protein networkhttps://string-db.org/network/511145.b2313Colicin V production protein; Required for colicin V production from plasmid IncFI ColV3- K30.
dedD protein networkhttps://string-db.org/network/511145.b2314Membrane-anchored periplasmic protein involved in septation; Non-essential cell division protein that could be required for efficient cell constriction; Belongs to the DedD family.
folC protein networkhttps://string-db.org/network/511145.b2315Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to [...]
accD protein networkhttps://string-db.org/network/511145.b2316acetyl-CoA carboxylase, beta (carboxyltransferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carr [...]
dedA protein networkhttps://string-db.org/network/511145.b2317DedA family inner membrane protein.
truA protein networkhttps://string-db.org/network/511145.b2318tRNA pseudouridine(38-40) synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
usg protein networkhttps://string-db.org/network/511145.b2319Putative semialdehyde dehydrogenase; Putative PTS system enzyme II A component.
pdxB protein networkhttps://string-db.org/network/511145.b2320Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase [...]
flk protein networkhttps://string-db.org/network/511145.b2321Putative flagella assembly protein; Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. [...]
yfcJ protein networkhttps://string-db.org/network/511145.b2322Putative arabinose efflux transporter; Overexpression has no effect on intracellular arabinose concentrations.
fabB protein networkhttps://string-db.org/network/511145.b23233-oxoacyl-[acyl-carrier-protein] synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongati [...]
mnmC protein networkhttps://string-db.org/network/511145.b2324tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble p [...]
yfcL protein networkhttps://string-db.org/network/511145.b2325Uncharacterized protein.
epmC protein networkhttps://string-db.org/network/511145.b2326Elongation Factor P Lys34 hydroxylase; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-l [...]
yfcA protein networkhttps://string-db.org/network/511145.b2327TauE/TSUP family inner membrane protein; Putative structural protein.
mepA protein networkhttps://string-db.org/network/511145.b2328Murein DD-endopeptidase; Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from [...]
aroC protein networkhttps://string-db.org/network/511145.b2329Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch poin [...]
prmB protein networkhttps://string-db.org/network/511145.b2330N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on 'Gln- 150'. Does not methylate the translation termination release factors RF1 and RF2; Belongs to the prot [...]
smrB protein networkhttps://string-db.org/network/511145.b2331Putative DNA endonuclease; Belongs to the UPF0115 family.
yfcO protein networkhttps://string-db.org/network/511145.b2332DUF2544 family putative outer membrane protein; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eu [...]
yfcP protein networkhttps://string-db.org/network/511145.b2333Putative fimbrial-like adhesin protein; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic [...]
yfcQ protein networkhttps://string-db.org/network/511145.b2334Putative fimbrial-like adhesin protein; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic [...]
yfcR protein networkhttps://string-db.org/network/511145.b2335Putative fimbrial-like adhesin protein; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic [...]
yfcS protein networkhttps://string-db.org/network/511145.b2336Putative periplasmic pilin chaperone; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T [...]
yfcV protein networkhttps://string-db.org/network/511145.b2339Uncharacterized fimbrial-like protein YfcV; Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukary [...]
sixA protein networkhttps://string-db.org/network/511145.b2340Phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay.
fadJ protein networkhttps://string-db.org/network/511145.b2341enoyl-CoA hydratase/epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimer [...]
fadI protein networkhttps://string-db.org/network/511145.b2342beta-ketoacyl-CoA thiolase, anaerobic, subunit; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. S [...]
yfcZ protein networkhttps://string-db.org/network/511145.b2343UPF0381 family protein; Belongs to the UPF0381 family.
fadL protein networkhttps://string-db.org/network/511145.b2344Long-chain fatty acid outer membrane transporter; Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specifi [...]
yfdF protein networkhttps://string-db.org/network/511145.b2345Protein involved in DNA metabolic process.
mlaA protein networkhttps://string-db.org/network/511145.b2346ABC transporter maintaining OM lipid asymmetry, OM lipoprotein component; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficki [...]
yfdC protein networkhttps://string-db.org/network/511145.b2347Putative transport protein.
intS protein networkhttps://string-db.org/network/511145.b2349CPS-53 (KpLE1) prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for [...]
gtrA protein networkhttps://string-db.org/network/511145.b2350CPS-53 (KpLE1) prophage; Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity); Belongs to the GtrA famil [...]
gtrB protein networkhttps://string-db.org/network/511145.b2351CPS-53 (KpLE1) prophage; Involved in O antigen modification. Catalyzes the transfer of the glucose residue from UDP-glucose to a lipid carrier (By similarity).
gtrS protein networkhttps://string-db.org/network/511145.b2352Serotype-specific glucosyl transferase, CPS-53 (KpLE1) prophage; Putative ligase.
yfdK protein networkhttps://string-db.org/network/511145.b2354Uncharacterized protein YfdK; Pseudogene, CPS-53 (KpLE1) prophage; tail fiber assembly protein fragment;Phage or Prophage Related; To E.coli YmfS.
yfdN protein networkhttps://string-db.org/network/511145.b2357Uncharacterized protein YfdN; CPS-53 (KpLE1) prophage; putative methyltransferase;Phage or Prophage Related.
yfdP protein networkhttps://string-db.org/network/511145.b2359Uncharacterized protein YfdP; Pseudogene, CPS-53 (KpLE1) prophage; bacteriophage replication protein O family;Phage or Prophage Related; To phage T4 y06Q.
yfdQ protein networkhttps://string-db.org/network/511145.b2360CPS-53 (KpLE1) prophage; uncharacterized protein.
yfdR protein networkhttps://string-db.org/network/511145.b2361CPS-53 (KpLE1) prophage; conserved protein.
yfdS protein networkhttps://string-db.org/network/511145.b2362CPS-53 (KpLE1) prophage; uncharacterized protein; To the N-terminal region of phage HK97/HK620 Gp37/hpaH.
yfdT protein networkhttps://string-db.org/network/511145.b2363CPS-53 (KpLE1) prophage; uncharacterized protein.
dsdC protein networkhttps://string-db.org/network/511145.b2364Dsd operon activator; Regulates the expression of the dsdX-dsdA operon.
dsdX protein networkhttps://string-db.org/network/511145.b2365D-serine transporter; A D-serine-specific transporter, may function as a H(+) symporter.
dsdA protein networkhttps://string-db.org/network/511145.b2366D-serine dehydratase (deaminase); Protein involved in cellular amino acid catabolic process.
emrY protein networkhttps://string-db.org/network/511145.b2367Putative multidrug efflux system; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
emrK protein networkhttps://string-db.org/network/511145.b2368Multidrug resistance efflux pump membrane fusion protein; Part of the tripartite efflux system EmrYK-TolC, which confers resistance to various drugs.
evgA protein networkhttps://string-db.org/network/511145.b2369Response regulator in two-component regulatory system with EvgS; Member of the two-component regulatory system EvgS/EvgA. Regulates the expression of emrKY operon and yfdX. Seems also to control [...]
evgS protein networkhttps://string-db.org/network/511145.b2370Hybrid sensory histidine kinase in two-component regulatory system with EvgA; Member of the two-component regulatory system EvgS/EvgA. Phosphorylates EvgA via a four-step phosphorelay in response [...]
yfdE protein networkhttps://string-db.org/network/511145.b2371acetyl-CoA:oxalate CoA-transferase; Involved in the catabolism of oxalate and in the adapatation to low pH. ACOCT serves to prime the oxalate-induced acid tolerance response (ATR) cycle by produc [...]
yfdV protein networkhttps://string-db.org/network/511145.b2372Putative receptor protein.
oxc protein networkhttps://string-db.org/network/511145.b2373Oxalyl CoA decarboxylase, ThDP-dependent; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyze [...]
frc protein networkhttps://string-db.org/network/511145.b2374formyl-CoA transferase, NAD(P)-binding; Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes [...]
yfdX protein networkhttps://string-db.org/network/511145.b2375Uncharacterized protein.
ypdI protein networkhttps://string-db.org/network/511145.b2376Putative lipoprotein involved in colanic acid biosynthesis.
yfdY protein networkhttps://string-db.org/network/511145.b2377DUF2545 family putative inner membrane protein.
lpxP protein networkhttps://string-db.org/network/511145.b2378Palmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmi [...]
alaC protein networkhttps://string-db.org/network/511145.b2379Glutamate-pyruvate aminotransferase; Involved in the biosynthesis of alanine.
ypdA protein networkhttps://string-db.org/network/511145.b2380Sensor kinase regulating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruvate si [...]
ypdB protein networkhttps://string-db.org/network/511145.b2381Response regulator activating yhjX; Member of the two-component regulatory system YpdA/YpdB, which is part of a nutrient-sensing regulatory network composed of YpdA/YpdB, the high-affinity pyruva [...]
ypdC protein networkhttps://string-db.org/network/511145.b2382Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
fryA protein networkhttps://string-db.org/network/511145.b2383Putative PTS enzyme: Hpr, enzyme I and IIA components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent suga [...]
ypdE protein networkhttps://string-db.org/network/511145.b2384Aminopeptidase; Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before th [...]
ypdF protein networkhttps://string-db.org/network/511145.b2385Xaa-Pro aminopeptidase; Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > [...]
fryC protein networkhttps://string-db.org/network/511145.b2386Putative enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of inco [...]
fryB protein networkhttps://string-db.org/network/511145.b2387Putative enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of [...]
glk protein networkhttps://string-db.org/network/511145.b2388Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate.
yfeO protein networkhttps://string-db.org/network/511145.b2389Putative ion channel protein.
ypeC protein networkhttps://string-db.org/network/511145.b2390DUF2502 family putative periplasmic protein; The overlapping reading frame (b2391) is no longer thought to be an actual gene, and has been deaccessioned; To E.coli YaaX.
mntH protein networkhttps://string-db.org/network/511145.b2392Manganese/divalent cation transporter; H(+)-stimulated, divalent metal cation uptake system. Involved in manganese and iron uptake. Can also transport cadmium, cobalt, zinc and to a lesser extent [...]
nupC protein networkhttps://string-db.org/network/511145.b2393Nucleoside (except guanosine) transporter; Transports nucleosides with a high affinity except guanosine and deoxyguanosine. Driven by a proton motive force. Transports cytidine, uridine, thymidin [...]
insL1-3 protein networkhttps://string-db.org/network/511145.b2394IS186 transposase.
yfeA protein networkhttps://string-db.org/network/511145.b2395Putative diguanylate cyclase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
yfeC protein networkhttps://string-db.org/network/511145.b2398DUF1323 family putative DNA-binding protein; To E.coli YfiI and P.aeruginosa RluD.
yfeD protein networkhttps://string-db.org/network/511145.b2399DUF1323 family putative DNA-binding protein.
gltX protein networkhttps://string-db.org/network/511145.b2400glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end [...]
xapR protein networkhttps://string-db.org/network/511145.b2405Transcriptional activator of xapAB; Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine.
xapB protein networkhttps://string-db.org/network/511145.b2406Xanthosine transporter; Uptake of xanthosine. Driven by a proton motive force. Can also transport other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine.
xapA protein networkhttps://string-db.org/network/511145.b2407Purine nucleoside phosphorylase 2; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the forma [...]
yfeN protein networkhttps://string-db.org/network/511145.b2408Putative outer membrane protein; Putative sugar hydrolase; Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.
yfeR protein networkhttps://string-db.org/network/511145.b2409Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yfeH protein networkhttps://string-db.org/network/511145.b2410Putative inorganic ion transporter; Putative cytochrome oxidase; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
ligA protein networkhttps://string-db.org/network/511145.b2411DNA ligase, NAD(+)-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and a [...]
zipA protein networkhttps://string-db.org/network/511145.b2412FtsZ stabilizer; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for t [...]
cysZ protein networkhttps://string-db.org/network/511145.b2413Sulfate transporter, sulfite inhibited; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis [...]
cysK protein networkhttps://string-db.org/network/511145.b2414Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; (Microbial infection) In addition to its role in cysteine synthesis, stimulates the tRNase activity of CdiA-CT from E.coli strain 536 [...]
ptsH protein networkhttps://string-db.org/network/511145.b2415Phosphohistidinoprotein-hexose phosphotransferase component of PTS system (Hpr); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar [...]
ptsI protein networkhttps://string-db.org/network/511145.b2416PEP-protein phosphotransferase of PTS system (enzyme I); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carboh [...]
crr protein networkhttps://string-db.org/network/511145.b2417Glucose-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphoryl [...]
pdxK protein networkhttps://string-db.org/network/511145.b2418Pyridoxal-pyridoxamine kinase/hydroxymethylpyrimidine kinase; B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), [...]
yfeK protein networkhttps://string-db.org/network/511145.b2419Uncharacterized protein.
yfeS protein networkhttps://string-db.org/network/511145.b2420WGR domain protein.
cysM protein networkhttps://string-db.org/network/511145.b2421Cysteine synthase B (O-acetylserine sulfhydrolase B); Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to [...]
cysA protein networkhttps://string-db.org/network/511145.b2422Sulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
cysW protein networkhttps://string-db.org/network/511145.b2423Sulfate/thiosulfate ABC transporter permease; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the [...]
cysU protein networkhttps://string-db.org/network/511145.b2424Sulfate/thiosulfate ABC transporter permease; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the [...]
cysP protein networkhttps://string-db.org/network/511145.b2425Thiosulfate-binding protein; Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its [...]
ucpA protein networkhttps://string-db.org/network/511145.b2426Furfural resistance protein, putative short-chain oxidoreductase; Putative oxidoreductase.
murR protein networkhttps://string-db.org/network/511145.b2427Repressor for murPQ, MurNAc 6-P inducible; Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted rep [...]
murQ protein networkhttps://string-db.org/network/511145.b2428N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. I [...]
murP protein networkhttps://string-db.org/network/511145.b2429N-acetylmuramic acid permease, EIIBC component, PTS system; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes [...]
yfeW protein networkhttps://string-db.org/network/511145.b2430Penicillin binding protein PBP4B; Penicillin-binding protein. Has low DD-carboxypeptidase activity; Belongs to the peptidase S12 family. YfeW subfamily.
yfeX protein networkhttps://string-db.org/network/511145.b2431Porphyrinogen oxidase, cytoplasmic; Has both general peroxidase activity and dye-decolorizing activity. Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to thei [...]
yfeY protein networkhttps://string-db.org/network/511145.b2432RpoE-regulated lipoprotein.
yfeZ protein networkhttps://string-db.org/network/511145.b2433Inner membrane protein.
ypeA protein networkhttps://string-db.org/network/511145.b2434GNAT family putative N-acetyltransferase; Belongs to the acetyltransferase family. YpeA subfamily.
amiA protein networkhttps://string-db.org/network/511145.b2435N-acetylmuramoyl-l-alanine amidase I; Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors.
hemF protein networkhttps://string-db.org/network/511145.b2436Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vin [...]
eutR protein networkhttps://string-db.org/network/511145.b2437Eut operon transcriptional activator, AraC family; Activates the transcription of the eut operon. Also positively regulates its own transcription. Probably binds ethanolamine and vitamin B12 as e [...]
eutK protein networkhttps://string-db.org/network/511145.b2438Putative ethanol utilization carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products t [...]
eutL protein networkhttps://string-db.org/network/511145.b2439Putative ethanol utilization carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products t [...]
eutC protein networkhttps://string-db.org/network/511145.b2440Ethanolamine ammonia-lyase, small subunit (light chain); Ethanolamine ammonia-lyase, light chain; Protein involved in amine catabolic process; Belongs to the EutC family.
eutB protein networkhttps://string-db.org/network/511145.b2441Ethanolamine ammonia-lyase, heavy chain; Protein involved in amine catabolic process.
intZ protein networkhttps://string-db.org/network/511145.b2442CPZ-55 prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision [...]
yffL protein networkhttps://string-db.org/network/511145.b2443CPZ-55 prophage; uncharacterized protein.
yffM protein networkhttps://string-db.org/network/511145.b2444CPZ-55 prophage; uncharacterized protein.
yffN protein networkhttps://string-db.org/network/511145.b2445CPZ-55 prophage; uncharacterized protein.
yffO protein networkhttps://string-db.org/network/511145.b2446CPZ-55 prophage; uncharacterized protein.
yffP protein networkhttps://string-db.org/network/511145.b2447CPZ-55 prophage; uncharacterized protein.
yffQ protein networkhttps://string-db.org/network/511145.b2448CPZ-55 prophage; uncharacterized protein.
yffR protein networkhttps://string-db.org/network/511145.b2449CPZ-55 prophage; uncharacterized protein.
yffS protein networkhttps://string-db.org/network/511145.b2450CPZ-55 prophage; uncharacterized protein.
eutA protein networkhttps://string-db.org/network/511145.b2451Reactivating factor for ethanolamine ammonia lyase; May protect the EutBC lyase from inhibition.
eutH protein networkhttps://string-db.org/network/511145.b2452Ethanolamine transporter; Possibly involved in the transport of ethanolamine from the periplasm to the cytoplasm.
eutG protein networkhttps://string-db.org/network/511145.b2453Ethanol dehydrogenase involved in ethanolamine utilization; May act on the acetaldehyde produced from the degradation of ethanolamine; Belongs to the iron-containing alcohol dehydrogenase family.
eutJ protein networkhttps://string-db.org/network/511145.b2454Ethanolamine utilization; homolog of Salmonella gene; Protein involved in amine catabolic process and protein folding.
eutE protein networkhttps://string-db.org/network/511145.b2455Aldehyde oxidoreductase, ethanolamine utilization protein; May act as an acetaldehyde dehydrogenase that converts acetaldehyde into acetyl-CoA.
eutN protein networkhttps://string-db.org/network/511145.b2456Ethanolamine catabolic microcompartment shell protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes p [...]
eutM protein networkhttps://string-db.org/network/511145.b2457Ethanolamine utilization protein, putative carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic [...]
eutD protein networkhttps://string-db.org/network/511145.b2458Phosphate acetyltransferase; Ethanolamine utilization; homolog of Salmonella acetyl/butyryl P transferase; Protein involved in amine catabolic process.
eutT protein networkhttps://string-db.org/network/511145.b2459Cobalamin adenosyltransferase involved in ethanolamine utilization; Converts CNB12 to ADOB12.
eutQ protein networkhttps://string-db.org/network/511145.b2460RmlC-like cupin domain protein; Protein involved in amine catabolic process.
eutP protein networkhttps://string-db.org/network/511145.b2461Putative P-loop NTPase ethanolamine utilization protein; Protein involved in amine catabolic process.
eutS protein networkhttps://string-db.org/network/511145.b2462Putative ethanol utilization carboxysome structural protein; May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products t [...]
maeB protein networkhttps://string-db.org/network/511145.b2463Malic enzyme: putative oxidoreductase/phosphotransacetylase; Putative multimodular enzyme; In the N-terminal section; belongs to the malic enzymes family.
talA protein networkhttps://string-db.org/network/511145.b2464Transaldolase A; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
tktB protein networkhttps://string-db.org/network/511145.b2465Transketolase 2, thiamine triphosphate-binding; Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-ph [...]
ypfG protein networkhttps://string-db.org/network/511145.b2466DUF1176 family protein.
nudK protein networkhttps://string-db.org/network/511145.b2467GDP-mannose pyrophosphatase; Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP- mannose as its preferred substrate, yielding GMP and mannose-1- phosphate. Can also hydrolyze the pyrophos [...]
aegA protein networkhttps://string-db.org/network/511145.b2468Putative oxidoreductase, FeS binding subunit/NAD/FAD-binding subunit.
narQ protein networkhttps://string-db.org/network/511145.b2469Sensory histidine kinase in two-component regulatory system with NarP; Acts as a sensor for nitrate/nitrite and transduces signal of nitrate/nitrite availability to the NarL/NarP proteins. NarQ p [...]
acrD protein networkhttps://string-db.org/network/511145.b2470Aminoglycoside/multidrug efflux system; Participates in the efflux of aminoglycosides. Confers resistance to a variety of these substances. Belongs to the resistance-nodulation-cell division (RND [...]
yffB protein networkhttps://string-db.org/network/511145.b2471Putative ArsC family reductase; Belongs to the ArsC family.
dapE protein networkhttps://string-db.org/network/511145.b2472N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in t [...]
ypfH protein networkhttps://string-db.org/network/511145.b2473palmitoyl-CoA esterase activity, uncertain physiological substrate; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate.
tmcA protein networkhttps://string-db.org/network/511145.b2474Elongator methionine tRNA (ac4C34) acetyltransferase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP ( [...]
ypfJ protein networkhttps://string-db.org/network/511145.b2475Putative neutral zinc metallopeptidase.
purC protein networkhttps://string-db.org/network/511145.b2476Phosphoribosylaminoimidazole-succinocarboxamide synthetase = SAICAR synthetase; Protein involved in purine nucleotide biosynthetic process.
bamC protein networkhttps://string-db.org/network/511145.b2477BamABCDE complex OM biogenesis lipoprotein; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. [...]
dapA protein networkhttps://string-db.org/network/511145.b2478Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). Belongs to the DapA family.
gcvR protein networkhttps://string-db.org/network/511145.b2479Transcriptional repressor, regulatory protein accessory to GcvA; Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is no [...]
bcp protein networkhttps://string-db.org/network/511145.b2480Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against [...]
hyfA protein networkhttps://string-db.org/network/511145.b2481Hydrogenase 4, 4Fe-4S subunit; Probable electron transfer protein for hydrogenase 4.
hyfB protein networkhttps://string-db.org/network/511145.b2482Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4.
hyfC protein networkhttps://string-db.org/network/511145.b2483Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 1 family.
hyfD protein networkhttps://string-db.org/network/511145.b2484Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family.
hyfE protein networkhttps://string-db.org/network/511145.b2485Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4.
hyfF protein networkhttps://string-db.org/network/511145.b2486Hydrogenase 4, membrane subunit; Possible component of hydrogenase 4. Belongs to the complex I subunit 5 family.
hyfG protein networkhttps://string-db.org/network/511145.b2487Hydrogenase 4, subunit; Possible component of hydrogenase 4.
hyfH protein networkhttps://string-db.org/network/511145.b2488Hydrogenase 4, Fe-S subunit; Probable electron transfer protein for hydrogenase 4.
hyfI protein networkhttps://string-db.org/network/511145.b2489Hydrogenase 4, Fe-S subunit; Possible component of hydrogenase 4. Belongs to the complex I 20 kDa subunit family.
hyfJ protein networkhttps://string-db.org/network/511145.b2490Putative processing element hydrogenase 4; Possible component of hydrogenase 4.
hyfR protein networkhttps://string-db.org/network/511145.b2491Hydrogenase-4 transcriptional activator; A transcriptional activator of its own operon; when overexpressed operon expression is strongly enhanced by low pH (under pH 6.0), strongly inhibited by O [...]
focB protein networkhttps://string-db.org/network/511145.b2492Putative formate transporter; Involved in the bidirectional transport of formate. Belongs to the FNT transporter (TC 2.A.44) family.
yfgO protein networkhttps://string-db.org/network/511145.b2493Putative UPF0118 family inner membrane permease; Putative permease.
bepA protein networkhttps://string-db.org/network/511145.b2494OM protein maintenance and assembly metalloprotease and chaperone, periplasmic; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting eit [...]
yfgD protein networkhttps://string-db.org/network/511145.b2495Putative oxidoreductase; Protein involved in xenobiotic metabolic process; Belongs to the ArsC family.
hda protein networkhttps://string-db.org/network/511145.b2496ATPase regulatory factor involved in DnaA inactivation; Mediates the interactions of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydro [...]
uraA protein networkhttps://string-db.org/network/511145.b2497Uracil permease; Transport of uracil in the cell. Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.
upp protein networkhttps://string-db.org/network/511145.b2498Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.
purM protein networkhttps://string-db.org/network/511145.b2499Phosphoribosylaminoimidazole synthetase = AIR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the AIR synthase family.
purN protein networkhttps://string-db.org/network/511145.b2500Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formy [...]
ppk protein networkhttps://string-db.org/network/511145.b2501Polyphosphate kinase, component of RNA degradosome; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orth [...]
ppx protein networkhttps://string-db.org/network/511145.b2502Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has a strong preference for long-chain polyphosphates a [...]
yfgF protein networkhttps://string-db.org/network/511145.b2503cyclic-di-GMP phosphodiesterase, anaerobic; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG. Truncated proteins consisting of the GGDEF/EAL domains (r [...]
yfgG protein networkhttps://string-db.org/network/511145.b2504Uncharacterized protein.
yfgH protein networkhttps://string-db.org/network/511145.b2505Putative outer membrane lipoprotein.
yfgI protein networkhttps://string-db.org/network/511145.b2506Nalidixic acid resistance protein, putative periplasmic protein; Putative membrane protein.
guaA protein networkhttps://string-db.org/network/511145.b2507GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP.
guaB protein networkhttps://string-db.org/network/511145.b2508IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleoti [...]
xseA protein networkhttps://string-db.org/network/511145.b2509Exonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. [...]
yfgJ protein networkhttps://string-db.org/network/511145.b2510DUF1407 family protein; Protein involved in biotin carboxyl carrier protein biosynthetic process.
der protein networkhttps://string-db.org/network/511145.b2511GTPase; GTPase that plays an essential role in the late steps of ribosome biogenesis. GTPase point mutations (but not a deletion mutant) are suppressed by mild overexpression of RelA, probably du [...]
bamB protein networkhttps://string-db.org/network/511145.b2512BamABCDE complex OM biogenesis lipoprotein; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. [...]
yfgM protein networkhttps://string-db.org/network/511145.b2513Ancillary SecYEG translocon subunit; putative anti-RcsB factor.
hisS protein networkhttps://string-db.org/network/511145.b2514Histidine tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
ispG protein networkhttps://string-db.org/network/511145.b25151-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, using flavodoxin as [...]
rodZ protein networkhttps://string-db.org/network/511145.b2516MreB assembly cytoskeletal protein; Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis. Belongs to the RodZ family.
rlmN protein networkhttps://string-db.org/network/511145.b2517Dual specificity 23S rRNA m(2)A2503, tRNA m(2)A37 methyltransferase, SAM-dependent; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 m [...]
ndk protein networkhttps://string-db.org/network/511145.b2518Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, [...]
pbpC protein networkhttps://string-db.org/network/511145.b2519Penicillin-insensitive murein repair transglycosylase; Cell wall formation. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a t [...]
yfhM protein networkhttps://string-db.org/network/511145.b2520Bacterial alpha2-macroglobulin colonization factor ECAM; Protects the bacterial cell from host peptidases. Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases le [...]
sseA protein networkhttps://string-db.org/network/511145.b25213-mercaptopyruvate sulfurtransferase; Transfers a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity (130-fold lower). Its participation in detoxification of cyan [...]
sseB protein networkhttps://string-db.org/network/511145.b2522Rhodanase-like enzyme, sulfur transfer from thiosulfate; May be involved in the enhancement of serine-sensitivity.
pepB protein networkhttps://string-db.org/network/511145.b2523Aminopeptidase B; Probably plays an important role in intracellular peptide degradation.
iscX protein networkhttps://string-db.org/network/511145.b2524Fe(2+) donor and activity modulator for cysteine desulfurase; May function as iron donor in the assembly of iron-sulfur clusters; Belongs to the IscX family.
fdx protein networkhttps://string-db.org/network/511145.b2525[2Fe-2S] ferredoxin; Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Although the function of this ferredoxin is unknown it is probable that [...]
hscA protein networkhttps://string-db.org/network/511145.b2526DnaK-like molecular chaperone specific for IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated [...]
hscB protein networkhttps://string-db.org/network/511145.b2527HscA co-chaperone, J domain-containing protein Hsc56; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA [...]
iscA protein networkhttps://string-db.org/network/511145.b2528FeS cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalyt [...]
iscU protein networkhttps://string-db.org/network/511145.b2529Iron-sulfur cluster assembly scaffold protein; A scaffold on which IscS assembles Fe-S clusters. Exists as 2 interconverting forms, a structured (S) and disordered (D) form. The D- state is the p [...]
iscS protein networkhttps://string-db.org/network/511145.b2530Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthe [...]
iscR protein networkhttps://string-db.org/network/511145.b2531Isc operon transcriptional repressor; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor [...]
trmJ protein networkhttps://string-db.org/network/511145.b2532tRNA mC32,mU32 2'-O-methyltransferase, SAM-dependent; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. Can also methylate adenosi [...]
suhB protein networkhttps://string-db.org/network/511145.b2533Inositol-1-monophosphatase; Protein involved in transcription.
yfhR protein networkhttps://string-db.org/network/511145.b2534Putative S9 family prolyl oligopeptidase; Putative enzyme (3.4.-).
csiE protein networkhttps://string-db.org/network/511145.b2535Stationary phase inducible protein.
hcaT protein networkhttps://string-db.org/network/511145.b2536Putative 3-phenylpropionic transporter; Probable permease involved in the uptake of 3-phenylpropionic acid; Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A. [...]
hcaR protein networkhttps://string-db.org/network/511145.b2537Hca operon transcriptional regulator; Transcriptional activator of the hca operon for 3- phenylpropionic acid catabolism.
hcaE protein networkhttps://string-db.org/network/511145.b25383-phenylpropionate dioxygenase, large (alpha) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropion [...]
hcaF protein networkhttps://string-db.org/network/511145.b25393-phenylpropionate dioxygenase, small (beta) subunit; Part of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropiona [...]
hcaC protein networkhttps://string-db.org/network/511145.b25403-phenylpropionate dioxygenase, ferredoxin subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phenylpropio [...]
hcaB protein networkhttps://string-db.org/network/511145.b25412,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Converts 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (CI-dihydrodiol) into 3-(2,3- dihydroxylphenyl)prop [...]
hcaD protein networkhttps://string-db.org/network/511145.b2542Phenylpropionate dioxygenase, ferredoxin reductase subunit; Part of the multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3-phen [...]
yphA protein networkhttps://string-db.org/network/511145.b2543DoxX family inner membrane protein.
yphB protein networkhttps://string-db.org/network/511145.b2544Mutarotase superfamily protein, YphB family.
yphC protein networkhttps://string-db.org/network/511145.b2545Putative oxidoreductase.
yphD protein networkhttps://string-db.org/network/511145.b2546Putative sugar ABC transporter permease; Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane; B [...]
yphE protein networkhttps://string-db.org/network/511145.b2547Putative sugar ABC transporter ATPase; Probably part of a binding-protein-dependent transport system YphDEF. Probably responsible for energy coupling to the transport system.
yphF protein networkhttps://string-db.org/network/511145.b2548Putative sugar ABC transporter periplasmic binding protein; Probably part of the binding-protein-dependent transport system YphDEF; Belongs to the bacterial solute-binding protein 2 family.
yphG protein networkhttps://string-db.org/network/511145.b2549DUF4380 domain-containing TPR repeat protein.
yphH protein networkhttps://string-db.org/network/511145.b2550Putative NAGC-like transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent; Belongs to the ROK (NagC/XylR) family.
glyA protein networkhttps://string-db.org/network/511145.b2551Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major so [...]
hmp protein networkhttps://string-db.org/network/511145.b2552Fused nitric oxide dioxygenase/dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H [...]
glnB protein networkhttps://string-db.org/network/511145.b2553Regulatory protein P-II for glutamine synthetase; P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-pho [...]
glrR protein networkhttps://string-db.org/network/511145.b2554Response regulator regulating glmY sRNA in two-component system with sensor protein GlrK; Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glmY sRNA [...]
yfhG protein networkhttps://string-db.org/network/511145.b2555Putative outer membrane protein modulating the QseEF response; Putative alpha helix protein.
glrK protein networkhttps://string-db.org/network/511145.b2556Sensor protein kinase regulating glmY sRNA in two-component system with response regulator GlrR; Member of the two-component regulatory system GlrR/GlrK that up-regulates transcription of the glm [...]
purL protein networkhttps://string-db.org/network/511145.b2557Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide [...]
mltF protein networkhttps://string-db.org/network/511145.b2558Membrane-bound lytic transglycosylase F, murein hydrolase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant fo [...]
tadA protein networkhttps://string-db.org/network/511145.b2559tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2). Essential for cell viability. Belongs to the cytidine and deoxycytidy [...]
pgpC protein networkhttps://string-db.org/network/511145.b2560Phosphatidylglycerophosphatase C, membrane bound; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
yfhH protein networkhttps://string-db.org/network/511145.b2561Putative DNA-binding transcriptional regulator.
yfhL protein networkhttps://string-db.org/network/511145.b2562Putative 4Fe-4S cluster-containing protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
acpS protein networkhttps://string-db.org/network/511145.b2563Holo-[acyl-carrier-protein] synthase 1; Transfers the 4'-phosphopantetheine moiety from coenzyme A to the 'Ser-36' of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS fam [...]
pdxJ protein networkhttps://string-db.org/network/511145.b2564Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amin [...]
recO protein networkhttps://string-db.org/network/511145.b2565Gap repair protein; Involved in DNA repair and RecF pathway recombination; Belongs to the RecO family.
era protein networkhttps://string-db.org/network/511145.b2566Membrane-associated, 16S rRNA-binding GTPase; An essential GTPase that binds both GDP and GTP, with nucleotide exchange occurring on the order of seconds whereas hydrolysis occurs on the order of [...]
rnc protein networkhttps://string-db.org/network/511145.b2567RNase III; Digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. Involved in the processing of rRNA precursors, viral transcripts, some mRNAs and at least 1 [...]
lepB protein networkhttps://string-db.org/network/511145.b2568Leader peptidase (signal peptidase I); Belongs to the peptidase S26 family.
lepA protein networkhttps://string-db.org/network/511145.b2569Back-translocating elongation factor EF4, GTPase; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, [...]
rseC protein networkhttps://string-db.org/network/511145.b2570SoxR iron-sulfur cluster reduction factor component; May play a role in reduction of the SoxR iron-sulfur cluster. May work together with the RsxABCDGE complex. Belongs to the RseC family.
rseB protein networkhttps://string-db.org/network/511145.b2571Anti-sigma E factor, binds RseA; Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea i [...]
rseA protein networkhttps://string-db.org/network/511145.b2572Anti-sigma factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by r [...]
rpoE protein networkhttps://string-db.org/network/511145.b2573RNA polymerase sigma E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic funct [...]
nadB protein networkhttps://string-db.org/network/511145.b2574Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate.
trmN protein networkhttps://string-db.org/network/511145.b2575tRNA1(Val) (adenine(37)-N6)-methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC); Belongs to the methyltransferase superfamily. tRNA (adenine- [...]
srmB protein networkhttps://string-db.org/network/511145.b2576ATP-dependent RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity. Acts [...]
yfiE protein networkhttps://string-db.org/network/511145.b2577Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
eamB protein networkhttps://string-db.org/network/511145.b2578Cysteine and O-acetylserine exporter; Exporter of O-acetylserine (OAS) and cysteine. Belongs to the Rht family.
grcA protein networkhttps://string-db.org/network/511145.b2579Autonomous glycyl radical cofactor; Acts as a radical domain for damaged PFL and possibly other radical proteins.
ung protein networkhttps://string-db.org/network/511145.b2580uracil-DNA-glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
yfiF protein networkhttps://string-db.org/network/511145.b2581Putative methyltransferase; Protein involved in RNA modification.
trxC protein networkhttps://string-db.org/network/511145.b2582Thioredoxin 2; Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin.
yfiP protein networkhttps://string-db.org/network/511145.b2583DTW domain protein.
pka protein networkhttps://string-db.org/network/511145.b2584Protein lysine acetyltransferase; Catalyzes the acetyl-CoA-dependent acetylation of lysine residues of a large number of target proteins. Acetylates RNase R in exponential phase cells and RNase I [...]
pssA protein networkhttps://string-db.org/network/511145.b2585Phosphatidylserine synthase; phospholipid synthesis; Protein involved in phospholipid biosynthetic process.
yfiM protein networkhttps://string-db.org/network/511145.b2586Putative lipoprotein.
kgtP protein networkhttps://string-db.org/network/511145.b2587Alpha-ketoglutarate transporter; Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system). Belongs to the major facilitator superfamily. [...]
clpB protein networkhttps://string-db.org/network/511145.b2592Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Ac [...]
yfiH protein networkhttps://string-db.org/network/511145.b2593UPF0124 family protein; Multicopper oxidase with polyphenol oxidase activity. Is able to oxidize syringaldazine and 2,2'-azino-bis(3-ethylbenzthiazoline-6- sulfonic acid) (ABTS) in vitro. The phy [...]
rluD protein networkhttps://string-db.org/network/511145.b259423S rRNA pseudouridine(1911,1915,1917) synthase; Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA. Isomerization occurs as a late step [...]
bamD protein networkhttps://string-db.org/network/511145.b2595BamABCDE complex OM biogenesis lipoprotein; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. [...]
raiA protein networkhttps://string-db.org/network/511145.b2597Cold shock protein associated with 30S ribosomal subunit; During stationary phase prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the [...]
pheL protein networkhttps://string-db.org/network/511145.b2598Leader peptide of chorismate mutase-P-prephenate dehydratase; Protein involved in L-phenylalanine biosynthetic process.
pheA protein networkhttps://string-db.org/network/511145.b2599Chorismate mutase and prephenate dehydratase, P-protein; Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
tyrA protein networkhttps://string-db.org/network/511145.b2600Chorismate mutase-T and prephenate dehydrogenase; Protein involved in L-phenylalanine biosynthetic process and tyrosine biosynthetic process.
aroF protein networkhttps://string-db.org/network/511145.b26013-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-ara [...]
yfiL protein networkhttps://string-db.org/network/511145.b2602Lipoprotein.
yfiR protein networkhttps://string-db.org/network/511145.b2603Putative periplasmic inhibitor of YfiN activity; Repressor of the cell division arrest function of DgcN. Prevents DgcN relocation to the midcell.
yfiN protein networkhttps://string-db.org/network/511145.b2604Putative membrane-anchored diguanylate cyclase; Bifunctional protein that catalyzes the synthesis of cyclic- di-GMP (c-di-GMP) in response to reductive stress and then dynamically relocates to th [...]
yfiB protein networkhttps://string-db.org/network/511145.b2605OM lipoprotein putative positive effector of YfiN activity; Putative outer membrane protein.
rplS protein networkhttps://string-db.org/network/511145.b260650S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface. In the 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S su [...]
trmD protein networkhttps://string-db.org/network/511145.b2607tRNA m(1)G37 methyltransferase, SAM-dependent; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
rimM protein networkhttps://string-db.org/network/511145.b2608Ribosome maturation factor; One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late assembly stage of the 30S ribosomal subunit. An accessory protein needed during the [...]
rpsP protein networkhttps://string-db.org/network/511145.b260930S ribosomal subunit protein S16; In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity.
ffh protein networkhttps://string-db.org/network/511145.b2610Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal se [...]
ypjD protein networkhttps://string-db.org/network/511145.b2611Cytochrome c assembly protein family inner membrane protein.
grpE protein networkhttps://string-db.org/network/511145.b2614Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the n [...]
nadK protein networkhttps://string-db.org/network/511145.b2615NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of [...]
recN protein networkhttps://string-db.org/network/511145.b2616Recombination and repair protein; May be involved in recombinational repair of damaged DNA; Belongs to the RecN family.
bamE protein networkhttps://string-db.org/network/511145.b2617Lipoprotein component of BamABCDE OM biogenesis complex; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the ou [...]
ratB protein networkhttps://string-db.org/network/511145.b2618UPF0125 family protein; Does not function as an antitoxin to the upstream RatA toxin; Belongs to the UPF0125 (RnfH) family.
ratA protein networkhttps://string-db.org/network/511145.b2619Toxic UPF0083 family protein inhibitor of 70S ribosome formation; Toxic component of a type II toxin-antitoxin (TA) system. Binds to 50S ribosomal subunits, preventing them from associating with [...]
smpB protein networkhttps://string-db.org/network/511145.b2620tmRNA-binding trans-translation protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to tmRNA RNA (also known as SsrA or 10Sa RNA, 363 nucleotides in this organ [...]
intA protein networkhttps://string-db.org/network/511145.b2622CP4-57 prophage; Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision [...]
yfjH protein networkhttps://string-db.org/network/511145.b2623CP4-57 prophage; Putative histone.
alpA protein networkhttps://string-db.org/network/511145.b2624CP4-57 prophage; Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for th [...]
yfjI protein networkhttps://string-db.org/network/511145.b2625CP4-57 prophage; uncharacterized protein.
yfjJ protein networkhttps://string-db.org/network/511145.b2626CP4-57 prophage; uncharacterized protein; To E.coli YagK.
yfjK protein networkhttps://string-db.org/network/511145.b2627Radiation resistance protein; DEAD/H helicase-like protein; CP4-57 putative defective prophage.
yfjL protein networkhttps://string-db.org/network/511145.b2628CP4-57 putative defective prophage, DUF4297/DUF1837 polymorphic toxin family protein.
yfjM protein networkhttps://string-db.org/network/511145.b2629CP4-57 prophage; uncharacterized protein.
rnlA protein networkhttps://string-db.org/network/511145.b2630CP4-57 prophage; Toxic component of a type II toxin-antitoxin (TA) system. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA [...]
rnlB protein networkhttps://string-db.org/network/511145.b2631CP4-57 prophage; Antitoxin component of a type II toxin-antitoxin (TA) system. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not [...]
yfjP protein networkhttps://string-db.org/network/511145.b2632CP4-57 prophage; Putative GTP-binding protein; To E.coli YkfA and YeeP.
yfjQ protein networkhttps://string-db.org/network/511145.b2633CP4-57 prophage; uncharacterized protein; Belongs to the UPF0380 family.
yfjR protein networkhttps://string-db.org/network/511145.b2634CP4-57 prophage; putative DNA-binding transcriptional regulator.
ypjK protein networkhttps://string-db.org/network/511145.b2635CP4-57 prophage; putative inner membrane protein; To E.coli YkfL.
yfjS protein networkhttps://string-db.org/network/511145.b2636CP4-57 prophage; Does not induce degP when overexpressed unless it is mutated to resemble YafY.
yfjT protein networkhttps://string-db.org/network/511145.b2637CP4-57 prophage; putative periplasmic protein; To E.coli YkfB.
yfjW protein networkhttps://string-db.org/network/511145.b2642Uncharacterized protein YfjW; Pseudogene, CP4-57 prophage;Phage or Prophage Related; putative pump protein.
yfjX protein networkhttps://string-db.org/network/511145.b2643Uncharacterized protein YfjX; Pseudogene, CP4-57 putative prophage remnant;Phage or Prophage Related; Belongs to the antirestriction protein family.
yfjY protein networkhttps://string-db.org/network/511145.b2644CP4-57 prophage; Putative DNA repair protein; Belongs to the UPF0758 family.
yfjZ protein networkhttps://string-db.org/network/511145.b2645CP4-57 prophage; Antitoxin component of a type IV toxin-antitoxin (TA) system. Antitoxin that counteracts the effect of cognate toxin YpjF. Also counteracts the effect of non-cognate toxins CbtA [...]
ypjF protein networkhttps://string-db.org/network/511145.b2646CP4-57 prophage; Toxic component of a type IV toxin-antitoxin (TA) system. Acts as a dual toxin inhibitor that blocks cell division and cell elongation in genetically separable interactions with [...]
ypjA protein networkhttps://string-db.org/network/511145.b2647Adhesin-like autotransporter; Putative ATP-binding component of a transport system.
csiD protein networkhttps://string-db.org/network/511145.b2659tRNA-Ile; Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG) in the stationary phase of E.coli. Functions in a L-lysine [...]
lhgO protein networkhttps://string-db.org/network/511145.b2660L-2-hydroxyglutarate oxidase; Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into [...]
gabD protein networkhttps://string-db.org/network/511145.b2661Succinate-semialdehyde dehydrogenase I, NADP-dependent; Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. Thereby functions in a GABA degradation pathway that allo [...]
gabT protein networkhttps://string-db.org/network/511145.b26624-aminobutyrate aminotransferase, PLP-dependent; Pyridoxal phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto acids. Catalyzes the transfer of the amin [...]
gabP protein networkhttps://string-db.org/network/511145.b2663Gamma-aminobutyrate transporter; Transporter for GABA; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
csiR protein networkhttps://string-db.org/network/511145.b2664Transcriptional repressor of csiD; Negatively regulates the expression of the glaH-lhgD-gabDTP operon in a temporal manner during entry into stationary phase or during the first few hours of carb [...]
ygaU protein networkhttps://string-db.org/network/511145.b2665Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) conc [...]
yqaE protein networkhttps://string-db.org/network/511145.b2666cyaR sRNA-regulated protein.
ygaV protein networkhttps://string-db.org/network/511145.b2667Tributyltin-inducible repressor of ygaVP; Functions as transcription repressor.
ygaP protein networkhttps://string-db.org/network/511145.b2668DUF2892 family inner membrane rhodanese.
stpA protein networkhttps://string-db.org/network/511145.b2669DNA binding protein, nucleoid-associated; A DNA-binding protein that acts in a fashion similar to H-NS protein upon overexpression, represses a number of genes including the cryptic blg operon, h [...]
alaE protein networkhttps://string-db.org/network/511145.b2670Alanine exporter, alanine-inducible, stress-responsive; Exports L-alanine; Belongs to the AlaE exporter family.
ygaC protein networkhttps://string-db.org/network/511145.b2671Uncharacterized protein.
ygaM protein networkhttps://string-db.org/network/511145.b2672Putative membrane-anchored DUF883 family ribosome-binding protein.
nrdH protein networkhttps://string-db.org/network/511145.b2673Hydrogen donor for NrdEF electron transport system; Electron transport system for the ribonucleotide reductase system NrdEF; Belongs to the glutaredoxin family.
nrdI protein networkhttps://string-db.org/network/511145.b2674NrdEF cluster assembly flavodoxin; Probably involved in ribonucleotide reductase function. Belongs to the NrdI family.
nrdE protein networkhttps://string-db.org/network/511145.b2675Ribonucleoside-diphosphate reductase 2, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotid [...]
nrdF protein networkhttps://string-db.org/network/511145.b2676Ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corre [...]
proV protein networkhttps://string-db.org/network/511145.b2677Glycine betaine/proline ABC transporter periplasmic binding protein; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for ener [...]
proW protein networkhttps://string-db.org/network/511145.b2678Glycine betaine/proline ABC transporter permease; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Probably responsible for the translocation of th [...]
proX protein networkhttps://string-db.org/network/511145.b2679Glycine betaine/proline ABC transporter periplasmic binding protein; Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake. Binds glycine betaine and pro [...]
ygaZ protein networkhttps://string-db.org/network/511145.b2682Inner membrane protein YgaZ; Pseudogene, major facilitator transporter superfamily;putative transport; Not classified; putative transport protein; Protein involved in response to stress.
ygaH protein networkhttps://string-db.org/network/511145.b2683Putative L-valine exporter, norvaline resistance protein.
mprA protein networkhttps://string-db.org/network/511145.b2684Transcriptional repressor of microcin B17 synthesis and multidrug efflux; Negative regulator of the multidrug operon emrAB.
emrA protein networkhttps://string-db.org/network/511145.b2685Multidrug efflux system; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid. EmrA is a drug-binding [...]
emrB protein networkhttps://string-db.org/network/511145.b2686Multidrug efflux system protein; Part of the tripartite efflux system EmrAB-TolC, which confers resistance to antibiotics such as CCCP, FCCP, 2,4-dinitrophenol and nalidixic acid.
luxS protein networkhttps://string-db.org/network/511145.b2687S-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the en [...]
gshA protein networkhttps://string-db.org/network/511145.b2688Glutamate-cysteine ligase; Protein involved in glutathione biosynthetic process; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.
yqaA protein networkhttps://string-db.org/network/511145.b2689COG1238 family inner membrane protein.
yqaB protein networkhttps://string-db.org/network/511145.b2690fructose-1-P and 6-phosphogluconate phosphatase; Catalyzes strongly the dephosphorylation of fructose-1- phosphate (Fru1P) and slightly the dephosphorylation of 6- phosphogluconate (6P-Glu). It h [...]
csrA protein networkhttps://string-db.org/network/511145.b2696Pleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability, initially identified for its e [...]
alaS protein networkhttps://string-db.org/network/511145.b2697alanyl-tRNA synthetase; Catalyzes the attachment of L-alanine to tRNA(Ala) in a two- step reaction: L-alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of [...]
recX protein networkhttps://string-db.org/network/511145.b2698Regulatory protein for RecA; Modulates RecA activity through direct physical interaction. Can inhibit both RecA recombinase and coprotease activities. May have a regulatory role during the SOS re [...]
recA protein networkhttps://string-db.org/network/511145.b2699DNA recombination and repair protein; Required for homologous recombination and the bypass of mutagenic DNA lesions by the SOS response. Catalyzes ATP-driven homologous pairing and strand exchang [...]
pncC protein networkhttps://string-db.org/network/511145.b2700Nicotinamide-nucleotide amidohydrolase; Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates; Belongs to the CinA family. PncC subfamily.
mltB protein networkhttps://string-db.org/network/511145.b2701Membrane-bound lytic murein transglycosylase B; Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidogly [...]
srlA protein networkhttps://string-db.org/network/511145.b2702Glucitol/sorbitol-specific enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosph [...]
srlE protein networkhttps://string-db.org/network/511145.b2703Glucitol/sorbitol-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the [...]
srlB protein networkhttps://string-db.org/network/511145.b2704Glucitol/sorbitol-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the [...]
srlD protein networkhttps://string-db.org/network/511145.b2705Glucitol (sorbitol)-6-phosphate dehydrogenase; Protein involved in carbohydrate catabolic process.
srlM protein networkhttps://string-db.org/network/511145.b2706Sorbitol=responsive srl operon transcriptional activator; Positive regulator for glucitol operon expression.
srlR protein networkhttps://string-db.org/network/511145.b2707Sorbitol-inducible srl operon transcriptional repressor; Regulator for gut (srl), glucitol operon; Protein involved in carbohydrate catabolic process, transcription and regulation of transcriptio [...]
srlQ protein networkhttps://string-db.org/network/511145.b2708D-arabinose 5-phosphate isomerase; Catalyzes the reversible aldol-ketol isomerization between D- ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). It appears that the physiological f [...]
norR protein networkhttps://string-db.org/network/511145.b2709Anaerobic nitric oxide reductase DNA-binding transcriptional activator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the [...]
norV protein networkhttps://string-db.org/network/511145.b2710Anaerobic nitric oxide reductase flavorubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reducta [...]
norW protein networkhttps://string-db.org/network/511145.b2711NADH:flavorubredoxin oxidoreductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase; Belongs to the FAD-dependent [...]
hypF protein networkhttps://string-db.org/network/511145.b2712Carbamoyl phosphate phosphatase and [NiFe] hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the [...]
hydN protein networkhttps://string-db.org/network/511145.b2713Formate dehydrogenase-H, [4Fe-4S] ferredoxin subunit; Electron transport from formate to hydrogen.
ascG protein networkhttps://string-db.org/network/511145.b2714Asc operon transcriptional repressor; Repressor of the asc operon. The cryptic operon is activated by the insertion of IS186 into the ascG gene.
ascF protein networkhttps://string-db.org/network/511145.b2715Cellobiose/arbutin/salicin-specific PTS enzymes, IIB and IC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport syste [...]
ascB protein networkhttps://string-db.org/network/511145.b2716Cryptic 6-phospho-beta-glucosidase; Can hydrolyze salicin, cellobiose, and probably arbutin; Belongs to the glycosyl hydrolase 1 family.
hycI protein networkhttps://string-db.org/network/511145.b2717Protease involved in processing C-terminal end of HycE; Protease involved in the C-terminal processing of HycE, the large subunit of hydrogenase 3; Belongs to the peptidase A31 family.
hycH protein networkhttps://string-db.org/network/511145.b2718Hydrogenase 3 maturation protein; Seems to be required for the conversion of a precursor form of the large subunit of hydrogenlyase (HycE) into a mature form.
hycG protein networkhttps://string-db.org/network/511145.b2719Hydrogenase 3 and formate hydrogenase complex, HycG subunit; Hydrogenase activity; Protein involved in fermentation and anaerobic respiration.
hycF protein networkhttps://string-db.org/network/511145.b2720Formate hydrogenlyase complex iron-sulfur protein; Probable electron transfer protein for hydrogenase 3.
hycE protein networkhttps://string-db.org/network/511145.b2721Large subunit of hydrogenase 3 (part of FHL complex); Protein involved in fermentation and anaerobic respiration; Belongs to the complex I 49 kDa subunit family.
hycD protein networkhttps://string-db.org/network/511145.b2722Membrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 1 family.
hycC protein networkhttps://string-db.org/network/511145.b2723Membrane-spanning protein of hydrogenase 3 (part of FHL complex); Protein involved in fermentation; Belongs to the complex I subunit 4 family.
hycB protein networkhttps://string-db.org/network/511145.b2724Hydrogenase 3, Fe-S subunit; Probable electron transfer protein for hydrogenase 3.
hycA protein networkhttps://string-db.org/network/511145.b2725Regulator of the transcriptional regulator FhlA; Regulatory protein for the formate hydrogenlyase system. Could act by directly interacting with FhlA or by preventing the binding of FhlA to the u [...]
hypA protein networkhttps://string-db.org/network/511145.b2726Protein involved in nickel insertion into hydrogenases 3; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Mediates trans [...]
hypB protein networkhttps://string-db.org/network/511145.b2727GTP hydrolase involved in nickel liganding into hydrogenases; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a [...]
hypC protein networkhttps://string-db.org/network/511145.b2728Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HypC delivers iron-bound CO(2) to HypD where reduction [...]
hypD protein networkhttps://string-db.org/network/511145.b2729Hydrogenase maturation protein; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HypD may act as a scaffold on which the Fe(CN)(2)CO co [...]
hypE protein networkhttps://string-db.org/network/511145.b2730Carbamoyl dehydratase, hydrogenases 1,2,3 maturation protein; Involved in the maturation of [NiFe] hydrogenases. Along with HypF, it catalyzes the synthesis of the CN ligands of the active site i [...]
fhlA protein networkhttps://string-db.org/network/511145.b2731Formate hydrogenlyase transcriptional activator; Required for induction of expression of the formate dehydrogenase H and hydrogenase-3 structural genes. Also activates expression of hyf operon (e [...]
ygbA protein networkhttps://string-db.org/network/511145.b2732Uncharacterized protein.
mutS protein networkhttps://string-db.org/network/511145.b2733Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATP [...]
pphB protein networkhttps://string-db.org/network/511145.b2734Serine/threonine-specific protein phosphatase 2; Has been shown, in vitro, to act on Ser, Thr and Tyr- phosphorylated substrates; Belongs to the PPP phosphatase family.
ygbI protein networkhttps://string-db.org/network/511145.b2735Putative DEOR-type transcriptional regulator; Protein involved in transcription repressor activity and transcription.
ygbJ protein networkhttps://string-db.org/network/511145.b2736Putative dehydrogenase; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+); Belongs to the HIBADH-related family. [...]
ygbK protein networkhttps://string-db.org/network/511145.b2737FliA-regulated DUF1537 family protein; Catalyzes the ATP-dependent phosphorylation of 3-oxo- tetronate to 3-oxo-tetronate 4-phosphate.
ygbL protein networkhttps://string-db.org/network/511145.b2738Putative class II aldolase; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2). Belongs to the aldolase class II family. AraD/FucA subfami [...]
ygbM protein networkhttps://string-db.org/network/511145.b2739Putative hydroxypyruvate isomerase; Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo- tetronate.
ygbN protein networkhttps://string-db.org/network/511145.b2740Putative transport protein.
rpoS protein networkhttps://string-db.org/network/511145.b2741RNA polymerase, sigma S (sigma 38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor [...]
nlpD protein networkhttps://string-db.org/network/511145.b2742Activator of AmiC murein hydrolase activity, lipoprotein; Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division.
pcm protein networkhttps://string-db.org/network/511145.b2743L-isoaspartate protein carboxylmethyltransferase type II; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of norm [...]
umpG protein networkhttps://string-db.org/network/511145.b2744Broad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ri [...]
truD protein networkhttps://string-db.org/network/511145.b2745tRNA(Glu) pseudouridine(13) synthase; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
ispF protein networkhttps://string-db.org/network/511145.b27462C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid [...]
ispD protein networkhttps://string-db.org/network/511145.b27474-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
ftsB protein networkhttps://string-db.org/network/511145.b2748Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, whi [...]
ygbE protein networkhttps://string-db.org/network/511145.b2749DUF3561 family inner membrane protein; Putative cytochrome oxidase subunit.
cysC protein networkhttps://string-db.org/network/511145.b2750Adenosine 5'-phosphosulfate kinase; Catalyzes the synthesis of activated sulfate.
cysN protein networkhttps://string-db.org/network/511145.b2751Sulfate adenylyltransferase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity.
cysD protein networkhttps://string-db.org/network/511145.b2752ATP:sulfurylase (ATP:sulfate adenylyltransferase), subunit 2; Protein involved in sulfur metabolic process; Belongs to the PAPS reductase family. CysD subfamily.
iap protein networkhttps://string-db.org/network/511145.b2753Aminopeptidase in alkaline phosphatase isozyme conversion; This protein, presumably an aminopeptidase, mediates the conversion of E.coli alkaline phosphatase isozyme 1, to isozymes 2 and 3 by rem [...]
ygbF protein networkhttps://string-db.org/network/511145.b2754CRISPR adaptation ssRNA endonuclease; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (vir [...]
ygbT protein networkhttps://string-db.org/network/511145.b2755Multifunctional endonuclease Cas1, CRISPR adaptation protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobi [...]
casE protein networkhttps://string-db.org/network/511145.b2756CRISPR RNA precursor cleavage enzyme; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (vir [...]
casD protein networkhttps://string-db.org/network/511145.b2757CRISP RNA (crRNA) containing Cascade antiviral complex protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mo [...]
casC protein networkhttps://string-db.org/network/511145.b2758CRISP RNA (crRNA) containing Cascade antiviral complex protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mo [...]
casB protein networkhttps://string-db.org/network/511145.b2759CRISP RNA (crRNA) containing Cascade antiviral complex protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mo [...]
casA protein networkhttps://string-db.org/network/511145.b2760CRISP RNA (crRNA) containing Cascade antiviral complex protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mo [...]
ygcB protein networkhttps://string-db.org/network/511145.b2761Cascade complex anti-viral R-loop helicase-annealase Cas3; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile [...]
cysH protein networkhttps://string-db.org/network/511145.b2762Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
cysI protein networkhttps://string-db.org/network/511145.b2763Sulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several act [...]
cysJ protein networkhttps://string-db.org/network/511145.b2764Sulfite reductase, alpha subunit, flavoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities require [...]
queD protein networkhttps://string-db.org/network/511145.b27656-pyruvoyl tetrahydrobiopterin synthase (PTPS); Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde. Can also conve [...]
ygcN protein networkhttps://string-db.org/network/511145.b2766Putative oxidoreductase; Probably accepts electrons from YgcQ/YgcR and reduces a quinone; Belongs to the ETF-QO/FixC family.
ygcO protein networkhttps://string-db.org/network/511145.b2767Putative 4Fe-4S cluster-containing protein; Could be a 3Fe-4S cluster-containing protein. Probably participates in a redox process with YgcN, YgcQ and YgcR.
ygcP protein networkhttps://string-db.org/network/511145.b2768Putative anti-terminator regulatory protein.
ygcQ protein networkhttps://string-db.org/network/511145.b2769Putative flavoprotein; May play a role in a redox process; Belongs to the ETF alpha-subunit/FixB family.
ygcR protein networkhttps://string-db.org/network/511145.b2770Putative flavoprotein; May play a role in a redox process.
ygcS protein networkhttps://string-db.org/network/511145.b2771Putative MFS sugar transporter; Putative transport protein.
ygcW protein networkhttps://string-db.org/network/511145.b2774Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
yqcE protein networkhttps://string-db.org/network/511145.b2775Putative MFS transporter, inner membrane protein; Putative transport protein.
ygcE protein networkhttps://string-db.org/network/511145.b2776Putative kinase; Belongs to the FGGY kinase family.
queE protein networkhttps://string-db.org/network/511145.b27777-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to [...]
ygcG protein networkhttps://string-db.org/network/511145.b2778TPM domain protein, putative phosphatase.
eno protein networkhttps://string-db.org/network/511145.b2779Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. It is also a component of the RNA [...]
pyrG protein networkhttps://string-db.org/network/511145.b2780CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the [...]
mazG protein networkhttps://string-db.org/network/511145.b2781Nucleoside triphosphate pyrophosphohydrolase; Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the type II MazE-MazF toxin-antitoxin (TA) sy [...]
mazF protein networkhttps://string-db.org/network/511145.b2782mRNA interferase toxin, antitoxin is MazE; Toxic component of a type II toxin-antitoxin (TA) system. A sequence-specific endoribonuclease it inhibits protein synthesis by cleaving mRNA and induci [...]
mazE protein networkhttps://string-db.org/network/511145.b2783Antitoxin of the ChpA-ChpR toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MazF endoribonuclease toxin and neutralizes its [...]
relA protein networkhttps://string-db.org/network/511145.b2784(p)ppGpp synthetase I/GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activit [...]
rlmD protein networkhttps://string-db.org/network/511145.b278523S rRNA m(5)U1939 methyltransferase, SAM-dependent; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase [...]
barA protein networkhttps://string-db.org/network/511145.b2786Hybrid sensory histidine kinase, in two-component regulatory system with UvrY; Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA [...]
gudD protein networkhttps://string-db.org/network/511145.b2787D-glucarate dehydratase 1; Catalyzes the dehydration of glucarate to 5-keto-4-deoxy-D- glucarate (5-kdGluc). Also acts on L-idarate; Belongs to the mandelate racemase/muconate lactonizing enzyme [...]
gudX protein networkhttps://string-db.org/network/511145.b2788Glucarate dehydratase-related protein, substrate unknown; Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is unknown.
gudP protein networkhttps://string-db.org/network/511145.b2789Putative D-glucarate transporter; Uptake of D-glucarate; Belongs to the major facilitator superfamily. Phthalate permease family.
yqcA protein networkhttps://string-db.org/network/511145.b2790Short-chain flavodoxin, FMN-binding; Probable electron transporter; Belongs to the flavodoxin family. MioC subfamily.
truC protein networkhttps://string-db.org/network/511145.b2791tRNA(Ile1,Asp) pseudouridine(65) synthase; Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs; Belongs to the pseudouridine synthase RluA family.
yqcC protein networkhttps://string-db.org/network/511145.b2792DUF446 family protein; To the N-terminal of E.carotovora exoenzyme regulation regulon ORF1. The C-terminal part is colinear with YqcB.
syd protein networkhttps://string-db.org/network/511145.b2793SecY-interacting protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cel [...]
queF protein networkhttps://string-db.org/network/511145.b27947-cyano-7-deazaguanine reductase (NADPH-dependent); Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosin [...]
ygdH protein networkhttps://string-db.org/network/511145.b2795UPF0717 family protein; Catalyzes the hydrolysis of the N-glycosidic bond of diverse pyrimidine and purine nucleotide 5'-monophosphates, to form ribose 5- phosphate and the corresponding free bas [...]
sdaC protein networkhttps://string-db.org/network/511145.b2796Putative serine transporter; Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity.
sdaB protein networkhttps://string-db.org/network/511145.b2797L-serine dehydratase 2; Deaminates also threonine, particularly when it is present in high concentration; Belongs to the iron-sulfur dependent L-serine dehydratase family.
ygdG protein networkhttps://string-db.org/network/511145.b2798Ssb-binding protein, misidentified as ExoIX; Has flap endonuclease activity , but does not seem to have exonuclease activity (and. During DNA replication, flap endonucleases cleave the 5'-overhan [...]
fucO protein networkhttps://string-db.org/network/511145.b2799L-1,2-propanediol oxidoreductase; Protein involved in carbohydrate catabolic process and glycolate metabolic process; Belongs to the iron-containing alcohol dehydrogenase family.
fucA protein networkhttps://string-db.org/network/511145.b2800L-fuculose-1-phosphate aldolase; Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1- phosphate (Fuc1P) to yield dihydroxyacetone phosphate [...]
fucP protein networkhttps://string-db.org/network/511145.b2801L-fucose transporter; Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-a [...]
fucI protein networkhttps://string-db.org/network/511145.b2802L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. Is also able to convert D-arabinose into D-ribulose, but this isomerase has a higher affinity for fucos [...]
fucK protein networkhttps://string-db.org/network/511145.b2803L-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Can also phosphorylate, with lower efficiency, D-ribulose, D-xylulose and D- fructose.
fucU protein networkhttps://string-db.org/network/511145.b2804L-fucose mutarotase; Involved in the anomeric conversion of L-fucose. Catalyzes also the interconversion of beta-pyran and beta-furan forms of D- ribose; Belongs to the RbsD / FucU family. FucU m [...]
fucR protein networkhttps://string-db.org/network/511145.b2805L-fucose operon activator; Transcriptional activator of the fuc operon.
rlmM protein networkhttps://string-db.org/network/511145.b280623S rRNA C2498 2'-O-ribose methyltransferase, SAM-dependent; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA. Modifies C2498 in naked 23S rRNA, but not in assembled 50S subunits or [...]
ygdD protein networkhttps://string-db.org/network/511145.b2807UPF0382 family inner membrane protein.
gcvA protein networkhttps://string-db.org/network/511145.b2808Glycine cleavage system transcriptional activator; Regulatory protein for the glycine cleavage system operon (gcv). Mediates activation of gcv by glycine and repression by purines. GcvA is negati [...]
ygdI protein networkhttps://string-db.org/network/511145.b2809DUF903 family verified lipoprotein.
csdA protein networkhttps://string-db.org/network/511145.b2810Cysteine sulfinate desulfinase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine, and transientl [...]
csdE protein networkhttps://string-db.org/network/511145.b2811CsdA-binding activator; Stimulates the cysteine desulfurase activity of CsdA. Contains a cysteine residue (Cys-61) that acts to accept sulfur liberated via the desulfurase activity of CsdA. May b [...]
tcdA protein networkhttps://string-db.org/network/511145.b2812tRNA threonylcarbamoyladenosine dehydratase; Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read co [...]
mltA protein networkhttps://string-db.org/network/511145.b2813Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands a [...]
amiC protein networkhttps://string-db.org/network/511145.b2817N-acetylmuramoyl-L-alanine amidase; Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors; Belong [...]
argA protein networkhttps://string-db.org/network/511145.b2818Amino acid N-acetyltransferase and inactive acetylglutamate kinase; N-acetylglutamate synthase; amino acid acetyltransferase; Protein involved in arginine biosynthetic process; Belongs to the ace [...]
recD protein networkhttps://string-db.org/network/511145.b2819Exonuclease V (RecBCD complex), alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and high [...]
recB protein networkhttps://string-db.org/network/511145.b2820Exonuclease V (RecBCD complex), beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and hig [...]
ptrA protein networkhttps://string-db.org/network/511145.b2821Protease III; Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.
recC protein networkhttps://string-db.org/network/511145.b2822Exonuclease V (RecBCD complex), gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a rapid (>1 kb/second) and high [...]
ppdC protein networkhttps://string-db.org/network/511145.b2823Putative prepilin peptidase-dependent protein; Not yet known.
ygdB protein networkhttps://string-db.org/network/511145.b2824DUF2509 family protein.
ppdB protein networkhttps://string-db.org/network/511145.b2825Putative prepilin peptidase-dependent protein; Not yet known.
ppdA protein networkhttps://string-db.org/network/511145.b2826Putative prepilin peptidase-dependent protein; Not yet known.
thyA protein networkhttps://string-db.org/network/511145.b2827Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate [...]
lgt protein networkhttps://string-db.org/network/511145.b2828Phosphatidylglycerol-prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of [...]
ptsP protein networkhttps://string-db.org/network/511145.b2829PEP-protein phosphotransferase enzyme I; Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regula [...]
rppH protein networkhttps://string-db.org/network/511145.b2830RNA pyrophosphohydrolase; Master regulator of 5'-end-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading t [...]
mutH protein networkhttps://string-db.org/network/511145.b2831Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.
ygdQ protein networkhttps://string-db.org/network/511145.b2832UPF0053 family inner membrane protein; Putative transport protein.
ygdR protein networkhttps://string-db.org/network/511145.b2833DUF903 family verified lipoprotein.
tas protein networkhttps://string-db.org/network/511145.b2834Putative NADP(H)-dependent aldo-keto reductase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
lplT protein networkhttps://string-db.org/network/511145.b2835Lysophospholipid transporter; Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell. Belongs to the major facilitator superfamily. LplT (TC 2.A.1 [...]
aas protein networkhttps://string-db.org/network/511145.b2836Fused 2-acylglycerophospho-ethanolamine acyl transferase/acyl-acyl carrier protein synthetase; Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bo [...]
galR protein networkhttps://string-db.org/network/511145.b2837Galactose-inducible d-galactose regulon transcriptional repressor; Repressor of the galactose operon. Binds galactose as an inducer.
lysA protein networkhttps://string-db.org/network/511145.b2838Diaminopimelate decarboxylase, PLP-binding; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimel [...]
lysR protein networkhttps://string-db.org/network/511145.b2839Transcriptional activator of lysA; This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression; Belon [...]
ygeA protein networkhttps://string-db.org/network/511145.b2840Asp/Glu_racemase family protein; Amino-acid racemase able to utilize a broad range of substrates. Highest activity is observed with L-homoserine and D- homoserine. Has tenfold lower activity agai [...]
araE protein networkhttps://string-db.org/network/511145.b2841Arabinose transporter; Uptake of arabinose across the boundary membrane with the concomitant transport of protons into the cell (symport system).
kduD protein networkhttps://string-db.org/network/511145.b28422-dehydro-3-deoxy-D-gluconate 5-dehydrogenase; Catalyzes the reversible reduction of 2,5-diketo-3- deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto- 3-deoxygluconate (KDG or [...]
kduI protein networkhttps://string-db.org/network/511145.b2843Hexuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity). Plays a role in the catabolism of hexuronates under [...]
yqeF protein networkhttps://string-db.org/network/511145.b2844Short chain acyltransferase; Putative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
yqeG protein networkhttps://string-db.org/network/511145.b2845Putative transporter protein.
yqeH protein networkhttps://string-db.org/network/511145.b2846Putative LuxR family transcriptional regulator; To E.coli YkgK.
yqeI protein networkhttps://string-db.org/network/511145.b2847Putative transcriptional regulator; Putative sensory transducer; To V.cholerae cholera toxin transcriptional activator (ToxR).
yqeJ protein networkhttps://string-db.org/network/511145.b2848Uncharacterized protein.
yqeK protein networkhttps://string-db.org/network/511145.b2849Uncharacterized protein.
ygeG protein networkhttps://string-db.org/network/511145.b2851Uncharacterized protein YgeG; Pseudogene; Belongs to the LcrH/SycD chaperone family.
ygeH protein networkhttps://string-db.org/network/511145.b2852Putative transcriptional regulator; Putative invasion protein.
ygeI protein networkhttps://string-db.org/network/511145.b2853Uncharacterized protein.
insD1-4 protein networkhttps://string-db.org/network/511145.b2860Pseudogene, orgA family, part of T3SS PAI ETT2 remnant.
insC1-4 protein networkhttps://string-db.org/network/511145.b2861IS2 repressor TnpA.
ygeR protein networkhttps://string-db.org/network/511145.b2865tRNA-Gly; Anticodon: CCC; Belongs to the peptidase M23B family.
xdhA protein networkhttps://string-db.org/network/511145.b2866Xanthine dehydrogenase, molybdenum binding subunit; Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerob [...]
xdhB protein networkhttps://string-db.org/network/511145.b2867Xanthine dehydrogenase, FAD-binding subunit; Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic grow [...]
xdhC protein networkhttps://string-db.org/network/511145.b2868Xanthine dehydrogenase, Fe-S binding subunit; Iron-sulfur subunit of the xanthine dehydrogenase complex.
ygeV protein networkhttps://string-db.org/network/511145.b2869Putative transcriptional regulator; Protein involved in transcription activator activity and transcription.
ygeW protein networkhttps://string-db.org/network/511145.b2870Putative carbamoyltransferase; Putative carbamoyltransferase. No activity can be detected with allantoin or 25 other related compounds, including 20 naturally occurring amino acids, N-acetyl-L-or [...]
ygeX protein networkhttps://string-db.org/network/511145.b28712,3-diaminopropionate ammonia lyase, PLP-dependent; Catalyzes the alpha,beta-elimination reaction of both L- and D-alpha,beta-diaminopropionate (DAP) to form pyruvate and ammonia. In vitro the D- [...]
ygeY protein networkhttps://string-db.org/network/511145.b2872Putative deacetylase.
hyuA protein networkhttps://string-db.org/network/511145.b2873D-stereospecific phenylhydantoinase; Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'- position. Has no activity [...]
yqeA protein networkhttps://string-db.org/network/511145.b2874Putative kinase; Belongs to the carbamate kinase family.
yqeB protein networkhttps://string-db.org/network/511145.b2875XdhC-CoxI family protein with NAD(P)-binding Rossman fold; Putative synthases.
yqeC protein networkhttps://string-db.org/network/511145.b2876Putative selenium-dependent hydroxylase accessory protein.
mocA protein networkhttps://string-db.org/network/511145.b2877CTP:molybdopterin cytidylyltransferase; Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin cytosine dinucleotide (Mo-MCD) [...]
ygfK protein networkhttps://string-db.org/network/511145.b2878Putative Fe-S subunit oxidoreductase subunit; Could be an iron-sulfur flavoprotein with NADPH:O(2) oxidoreductase activity.
ssnA protein networkhttps://string-db.org/network/511145.b2879Putative chlorohydrolase/aminohydrolase; Protein involved in cell cycle.
ygfM protein networkhttps://string-db.org/network/511145.b2880Putative oxidoreductase.
xdhD protein networkhttps://string-db.org/network/511145.b2881Putative hypoxanthine oxidase, molybdopterin-binding/Fe-S binding; Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this [...]
xanQ protein networkhttps://string-db.org/network/511145.b2882Xanthine permease; Specific, proton motive force-dependent high-affinity transporter for xanthine; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) [...]
guaD protein networkhttps://string-db.org/network/511145.b2883Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
ygfS protein networkhttps://string-db.org/network/511145.b2886Putative oxidoreductase, Fe-S subunit.
ygfT protein networkhttps://string-db.org/network/511145.b2887Putative oxidoreductase, Fe-S subunit.
uacT protein networkhttps://string-db.org/network/511145.b2888Uric acid permease; Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius; Belongs to t [...]
idi protein networkhttps://string-db.org/network/511145.b2889Isopentenyl diphosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DM [...]
lysS protein networkhttps://string-db.org/network/511145.b2890Lysine tRNA synthetase, constitutive; suppressor of ColE1 mutation in primer RNA; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-II aminoacyl-tRNA synthetas [...]
prfB protein networkhttps://string-db.org/network/511145.b2891Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Acts as a peptidyl-tRNA h [...]
recJ protein networkhttps://string-db.org/network/511145.b2892ssDNA exonuclease, 5' --> 3'-specific; Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to [...]
dsbC protein networkhttps://string-db.org/network/511145.b2893Protein disulfide isomerase II; Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing [...]
xerD protein networkhttps://string-db.org/network/511145.b2894Site-specific tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA co [...]
fldB protein networkhttps://string-db.org/network/511145.b2895Flavodoxin 2; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.
cptA protein networkhttps://string-db.org/network/511145.b2896Toxin of CptAB toxin-antitoxin pair; A probable inner membrane protein. Has been shown not to be a toxin, no effects on growth are seen in LB or minimal medium up to 6 or 21 hours (respectively) [...]
sdhE protein networkhttps://string-db.org/network/511145.b2897Flavinator of succinate dehydrogenase; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate deh [...]
ygfZ protein networkhttps://string-db.org/network/511145.b2898Iron-sulfur cluster repair protein, plumbagin resistance; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in [...]
yqfA protein networkhttps://string-db.org/network/511145.b2899Hemolysin III family HylIII inner membrane protein; Putative oxidoreductase.
yqfB protein networkhttps://string-db.org/network/511145.b2900UPF0267 family protein; Belongs to the UPF0267 family.
bglA protein networkhttps://string-db.org/network/511145.b29016-phospho-beta-glucosidase A; Catalyzes the hydrolysis of phosphorylated beta-glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glu [...]
ygfF protein networkhttps://string-db.org/network/511145.b2902Putative oxidoreductase.
gcvP protein networkhttps://string-db.org/network/511145.b2903Glycine decarboxylase, PLP-dependent, subunit P of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine [...]
gcvH protein networkhttps://string-db.org/network/511145.b2904Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T prote [...]
gcvT protein networkhttps://string-db.org/network/511145.b2905Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine.
ubiI protein networkhttps://string-db.org/network/511145.b29062-octaprenylphenol hydroxylase, FAD-dependent; FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the first hydroxylation s [...]
ubiH protein networkhttps://string-db.org/network/511145.b29072-octaprenyl-6-methoxyphenol hydroxylase, FAD/NAD(P)-binding; Is likely an oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation o [...]
pepP protein networkhttps://string-db.org/network/511145.b2908Proline aminopeptidase P II.
ygfB protein networkhttps://string-db.org/network/511145.b2909UPF0149 family protein; Belongs to the UPF0149 family.
zapA protein networkhttps://string-db.org/network/511145.b2910FtsZ stabilizer; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the div [...]
fau protein networkhttps://string-db.org/network/511145.b29125-formyltetrahydrofolate cyclo-ligase family protein; Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabol [...]
serA protein networkhttps://string-db.org/network/511145.b2913D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Als [...]
rpiA protein networkhttps://string-db.org/network/511145.b2914Ribose 5-phosphate isomerase, constitutive; Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate t [...]
argP protein networkhttps://string-db.org/network/511145.b2916HTH-type transcriptional regulator ArgP; Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, [...]
scpA protein networkhttps://string-db.org/network/511145.b2917methylmalonyl-CoA mutase; Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA. Could be part of a pathway that converts succinate to propionate.
argK protein networkhttps://string-db.org/network/511145.b2918Membrane ATPase/protein kinase; Binds and hydrolyzes GTP. Likely functions as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) ScpA and reactivati [...]
scpB protein networkhttps://string-db.org/network/511145.b2919methylmalonyl-CoA decarboxylase, biotin-independent; Catalyzes the decarboxylation of (R)-methylmalonyl-CoA to propionyl-CoA. Could be part of a pathway that converts succinate to propanoate.
scpC protein networkhttps://string-db.org/network/511145.b2920propionyl-CoA:succinate CoA transferase; Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate; Belongs to the ace [...]
ygfI protein networkhttps://string-db.org/network/511145.b2921Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yggE protein networkhttps://string-db.org/network/511145.b2922Oxidative stress defense protein; Putative actin.
argO protein networkhttps://string-db.org/network/511145.b2923Arginine transporter; Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the [...]
mscS protein networkhttps://string-db.org/network/511145.b2924Mechanosensitive channel protein, small conductance; Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch force [...]
fbaA protein networkhttps://string-db.org/network/511145.b2925Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-b [...]
pgk protein networkhttps://string-db.org/network/511145.b2926Phosphoglycerate kinase; Protein involved in glycolysis and gluconeogenesis; Belongs to the phosphoglycerate kinase family.
epd protein networkhttps://string-db.org/network/511145.b2927D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate.
yggC protein networkhttps://string-db.org/network/511145.b2928Putative PanK family P-loop kinase; Putative kinase.
yggD protein networkhttps://string-db.org/network/511145.b2929MtlR family putative transcriptional repressor; In vitro catalyzes the addition of water to fumarate, forming malate. Cannot catalyze the reverse reaction. Cannot use the cis-isomer maleate as su [...]
yggF protein networkhttps://string-db.org/network/511145.b2930Fructose 1,6 bisphosphatase isozyme; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6- bisphosphate, and no activity [...]
cmtA protein networkhttps://string-db.org/network/511145.b2933Putative mannitol-specific PTS IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the p [...]
cmtB protein networkhttps://string-db.org/network/511145.b2934Putative mannitol-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the [...]
tktA protein networkhttps://string-db.org/network/511145.b2935Transketolase 1, thiamine triphosphate-binding; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamin [...]
loiP protein networkhttps://string-db.org/network/511145.b2936Phe-Phe periplasmic metalloprotease, OM lipoprotein; Metalloprotease that cleaves substrates preferentially between Phe-Phe residues. Plays a role in response to some stress conditions. Seems to [...]
speB protein networkhttps://string-db.org/network/511145.b2937Agmatinase; Catalyzes the formation of putrescine from agmatine.
speA protein networkhttps://string-db.org/network/511145.b2938Biosynthetic arginine decarboxylase, PLP-binding; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
yqgB protein networkhttps://string-db.org/network/511145.b2939Uncharacterized protein; Belongs to the YqgB family.
yqgC protein networkhttps://string-db.org/network/511145.b2940Uncharacterized protein.
metK protein networkhttps://string-db.org/network/511145.b2942S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet forma [...]
galP protein networkhttps://string-db.org/network/511145.b2943D-galactose transporter; Uptake of galactose across the boundary membrane with the concomitant transport of protons into the cell (symport system); Belongs to the major facilitator superfamily. S [...]
yggI protein networkhttps://string-db.org/network/511145.b2944Zn-dependent metalloprotease-related protein; Involved in bolA gene expression at the stationary phase.
endA protein networkhttps://string-db.org/network/511145.b2945DNA-specific endonuclease I; Has double-strand break activity; Belongs to the EndA/NucM nuclease family.
rsmE protein networkhttps://string-db.org/network/511145.b294616S rRNA m(3)U1498 methyltransferase, SAM-dependent; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal su [...]
gshB protein networkhttps://string-db.org/network/511145.b2947Protein involved in glutathione biosynthetic process.
yqgE protein networkhttps://string-db.org/network/511145.b2948Uncharacterized protein; Belongs to the UPF0301 (AlgH) family.
yqgF protein networkhttps://string-db.org/network/511145.b2949Putative Holliday junction resolvase; Involved in the processing of the 5'-end of pre-16S rRNA during 70S ribosome maturation (processing does not occur on total cellular RNA off the ribosome); m [...]
yggR protein networkhttps://string-db.org/network/511145.b2950Putative PilT family AAA+ ATPase; Putative protein transport.
yggS protein networkhttps://string-db.org/network/511145.b2951UPF0001 family protein, PLP-binding; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. May have a carrier function to deliver PLP to the target enzymes or a prot [...]
yggT protein networkhttps://string-db.org/network/511145.b2952Conserved hypothetical integral membrane protein.
yggU protein networkhttps://string-db.org/network/511145.b2953UPF0235 family protein; Belongs to the UPF0235 family.
rdgB protein networkhttps://string-db.org/network/511145.b2954dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleot [...]
yggW protein networkhttps://string-db.org/network/511145.b2955HemN family putative oxidoreductase; Probably acts as a heme chaperone, transferring heme to the NarI subunit of the respiratory enzyme nitrate reductase; transfer may be stimulated by NADH. Bind [...]
yggM protein networkhttps://string-db.org/network/511145.b2956DUF1202 family putative secreted protein; Putative alpha helix chain.
ansB protein networkhttps://string-db.org/network/511145.b2957Periplasmic L-asparaginase 2; Protein involved in cellular amino acid catabolic process; Belongs to the asparaginase 1 family.
yggN protein networkhttps://string-db.org/network/511145.b2958DUF2884 family putative periplasmic protein.
yggL protein networkhttps://string-db.org/network/511145.b2959DUF469 family protein; To H.influenzae HI_0341.
trmI protein networkhttps://string-db.org/network/511145.b2960tRNA m(7)G46 methyltransferase, SAM-dependent; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. [...]
mutY protein networkhttps://string-db.org/network/511145.b2961Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dih [...]
yggX protein networkhttps://string-db.org/network/511145.b2962Oxidative damage protective factor for iron-sulfur proteins; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe- [...]
mltC protein networkhttps://string-db.org/network/511145.b2963Membrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Belongs to the transglycosylase [...]
nupG protein networkhttps://string-db.org/network/511145.b2964Nucleoside transporter; Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force. Can transport uridine, adenosine, inosine, guanosine, thymidine and cy [...]
speC protein networkhttps://string-db.org/network/511145.b2965Ornithine decarboxylase, constitutive; Ornithine decarboxylase isozyme; Protein involved in polyamine biosynthetic process.
yqgA protein networkhttps://string-db.org/network/511145.b2966DUF554 family putative inner membrane protein; Putative transport protein.
yghD protein networkhttps://string-db.org/network/511145.b2968Putative membrane-anchored secretion pathway M-type protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the ou [...]
yghG protein networkhttps://string-db.org/network/511145.b2971Lipoprotein YghG; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. In a functional T2SS this sub [...]
pppA protein networkhttps://string-db.org/network/511145.b2972Bifunctional prepilin leader peptidase/ methylase; A pre-pilin peptidase involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins a [...]
glcA protein networkhttps://string-db.org/network/511145.b2975Glycolate transporter; Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force.
glcB protein networkhttps://string-db.org/network/511145.b2976Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA.
glcG protein networkhttps://string-db.org/network/511145.b2977DUF336 family protein; Belongs to the GlcG family.
glcD protein networkhttps://string-db.org/network/511145.b2979Glycolate oxidase subunit, FAD-linked; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is a [...]
glcC protein networkhttps://string-db.org/network/511145.b2980Glycolate-inducible glc operon transcriptional repressor; Transcriptional activator of the glcDEFGB operon which is associated with glycolate utilization, and encodes malate synthase G and the ge [...]
insH1-9 protein networkhttps://string-db.org/network/511145.b2982Pseudogene, IS-interrupted.
yghQ protein networkhttps://string-db.org/network/511145.b2983Putative inner membrane polysaccharide flippase.
yghR protein networkhttps://string-db.org/network/511145.b2984Putative ATP-binding protein; To E.coli YghS and YghT.
yghS protein networkhttps://string-db.org/network/511145.b2985Putative ATP-binding protein; To E.coli YghR and YghT.
yghT protein networkhttps://string-db.org/network/511145.b2986Putative ATP-binding protein; To E.coli YghR and YghS.
pitB protein networkhttps://string-db.org/network/511145.b2987Phosphate transporter; Low-affinity inorganic phosphate transport; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
gss protein networkhttps://string-db.org/network/511145.b2988Glutathionylspermidine amidase and glutathionylspermidine synthetase; Catalyzes the formation of an amide bond between glutathione (GSH) and spermidine coupled with hydrolysis of ATP; also cataly [...]
yghU protein networkhttps://string-db.org/network/511145.b2989Putative S-transferase; Exhibits a robust glutathione (GSH)-dependent disulfide-bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates a [...]
hybG protein networkhttps://string-db.org/network/511145.b2990Hydrogenase 2 accessory protein; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor. HybG delivers iron-bound CO(2) to HypD where reductio [...]
hybF protein networkhttps://string-db.org/network/511145.b2991Protein involved with the maturation of hydrogenases 1 and 2; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. HybF is in [...]
hybE protein networkhttps://string-db.org/network/511145.b2992Hydrogenase 2-specific chaperone; Member of hyb operon.
hybD protein networkhttps://string-db.org/network/511145.b2993Maturation protease for hydrogenase 2; Protease involved in the C-terminal processing of HybC, the large subunit of hydrogenase 2. Specifically cleaves off a 15 amino acid peptide from the C-term [...]
hybC protein networkhttps://string-db.org/network/511145.b2994Hydrogenase 2, large subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[N [...]
hybB protein networkhttps://string-db.org/network/511145.b2995Putative hydrogenase 2 cytochrome b type component; Probable b-type cytochrome; Belongs to the NrfD family.
hybA protein networkhttps://string-db.org/network/511145.b2996Hydrogenase 2 4Fe-4S ferredoxin-type component; Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover.
hybO protein networkhttps://string-db.org/network/511145.b2997Hydrogenase 2, small subunit; This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake; Belongs to the [NiFe]/[N [...]
yghW protein networkhttps://string-db.org/network/511145.b2998DUF2623 family protein.
gpr protein networkhttps://string-db.org/network/511145.b3001L-glyceraldehyde 3-phosphate reductase; Catalyzes the stereospecific, NADPH-dependent reduction of L- glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L- [...]
yqhA protein networkhttps://string-db.org/network/511145.b3002UPF0114 family putative inner membrane protein.
yghA protein networkhttps://string-db.org/network/511145.b3003Putative oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
exbD protein networkhttps://string-db.org/network/511145.b3005Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
exbB protein networkhttps://string-db.org/network/511145.b3006Membrane spanning protein in TonB-ExbB-ExbD complex; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and [...]
metC protein networkhttps://string-db.org/network/511145.b3008Cystathionine beta-lyase, PLP-dependent; Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis. Also exhibits cysteine desulfhydra [...]
yghB protein networkhttps://string-db.org/network/511145.b3009General envelope maintenance protein; May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YqjA, for the proper export of certain periplasmic [...]
yqhC protein networkhttps://string-db.org/network/511145.b3010Transcriptional activator of yqhD; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
yqhD protein networkhttps://string-db.org/network/511145.b3011Aldehyde reductase, NADPH-dependent; NADP-dependent ADH activity; Belongs to the iron-containing alcohol dehydrogenase family.
dkgA protein networkhttps://string-db.org/network/511145.b30122,5-diketo-D-gluconate reductase A; Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on [...]
yqhG protein networkhttps://string-db.org/network/511145.b3013DUF3828 family putative periplasmic protein.
yqhH protein networkhttps://string-db.org/network/511145.b3014Outer membrane lipoprotein, Lpp paralog.
ftsP protein networkhttps://string-db.org/network/511145.b3017Septal ring component that protects the divisome from stress; Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisoma [...]
plsC protein networkhttps://string-db.org/network/511145.b30181-acyl-sn-glycerol-3-phosphate acyltransferase; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl- [...]
parC protein networkhttps://string-db.org/network/511145.b3019DNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes superc [...]
ygiS protein networkhttps://string-db.org/network/511145.b3020Putative ABC transporter permease; Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate [...]
mqsA protein networkhttps://string-db.org/network/511145.b3021Antitoxin for MqsR toxin; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activit [...]
mqsR protein networkhttps://string-db.org/network/511145.b3022GCU-specific mRNA interferase toxin of the MqsR-MqsA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Plays a significant role in the control of biofilm formation [...]
ygiV protein networkhttps://string-db.org/network/511145.b3023Transcriptional repressor for mcbR biofilm gene; Represses expression of mcbR.
ygiW protein networkhttps://string-db.org/network/511145.b3024Hydrogen peroxide and cadmium resistance periplasmic protein; stress-induced OB-fold protein.
qseB protein networkhttps://string-db.org/network/511145.b3025Quorum sensing DNA-binding response regulator in two-component regulatory system with QseC; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating tra [...]
qseC protein networkhttps://string-db.org/network/511145.b3026Quorum sensing sensory histidine kinase in two-component regulatory system with QseB; Member of a two-component regulatory system QseB/QseC. Activates the flagella regulon by activating transcrip [...]
ygiZ protein networkhttps://string-db.org/network/511145.b3027Inner membrane protein.
mdaB protein networkhttps://string-db.org/network/511145.b3028NADPH quinone reductase; NADPH-specific quinone reductase. Is most active with quinone derivatives and ferricyanide as electron acceptors. Can use menadione, 1,4-naphthoquinone and 1,4-benzoquino [...]
ygiN protein networkhttps://string-db.org/network/511145.b3029Quinol monooxygenase; Can oxidize menadiol to menadione.
parE protein networkhttps://string-db.org/network/511145.b3030DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes. It relaxes superc [...]
yqiA protein networkhttps://string-db.org/network/511145.b3031Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate.
cpdA protein networkhttps://string-db.org/network/511145.b30323',5' cAMP phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. Sp [...]
yqiB protein networkhttps://string-db.org/network/511145.b3033DUF1249 protein YqiB; Putative enzyme.
nudF protein networkhttps://string-db.org/network/511145.b3034ADP-ribose pyrophosphatase; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogeni [...]
tolC protein networkhttps://string-db.org/network/511145.b3035Transport channel; Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in ex [...]
ygiB protein networkhttps://string-db.org/network/511145.b3037DUF1190 family protein; Belongs to the UPF0441 family.
ygiC protein networkhttps://string-db.org/network/511145.b3038ATP-Grasp family ATPase; May be a ligase forming an amide bond. Shows ATPase activity. Despite its similarity to the C-terminal synthetase domain of Gss, is not a glutathionylspermidine (Gsp) syn [...]
ygiD protein networkhttps://string-db.org/network/511145.b30394,5- DOPA-extradiol-dioxygenase; In vitro, opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically t [...]
zupT protein networkhttps://string-db.org/network/511145.b3040Zinc transporter; Mediates zinc uptake. May also transport other divalent cations such as copper and cadmium ions; Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
ribB protein networkhttps://string-db.org/network/511145.b30413,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
yqiC protein networkhttps://string-db.org/network/511145.b3042BMFP family putative fusogenic protein; Required for efficient ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. UbiK is probably an accessory factor of Ubi enzymes and facilitates u [...]
ygiL protein networkhttps://string-db.org/network/511145.b3043Putative fimbrial-like protein.
insC1-5 protein networkhttps://string-db.org/network/511145.b3044Pseudogene; fimbrial export usher family;putative membrane; Not classified; putative membrane protein.
insD1-5 protein networkhttps://string-db.org/network/511145.b3045IS2 transposase TnpB.
yqiH protein networkhttps://string-db.org/network/511145.b3047Putative periplasmic pilin chaperone; Could be required for the biogenesis of a putative fimbria. Belongs to the periplasmic pilus chaperone family.
yqiI protein networkhttps://string-db.org/network/511145.b3048Fimbrial protein; May be involved in a fimbrial system chaperoned by YqiH and exported by YqiG.
glgS protein networkhttps://string-db.org/network/511145.b3049Motility and biofilm regulator; Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.
yqiJ protein networkhttps://string-db.org/network/511145.b3050DUF1449 family inner membrane protein; Putative oxidoreductase.
yqiK protein networkhttps://string-db.org/network/511145.b3051PHB family membrane protein, function unknown; Putative membrane protein.
hldE protein networkhttps://string-db.org/network/511145.b3052Heptose 7-phosphate kinase and heptose 1-phosphate adenyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-bet [...]
glnE protein networkhttps://string-db.org/network/511145.b3053Fused deadenylyltransferase/adenylyltransferase for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular [...]
ygiF protein networkhttps://string-db.org/network/511145.b3054Inorganic triphosphatase; Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates (inorganic or nucleoside- linked). Catalyzes the hydrolysis o [...]
ygiM protein networkhttps://string-db.org/network/511145.b3055SH3 domain protein.
cca protein networkhttps://string-db.org/network/511145.b3056Fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without usin [...]
bacA protein networkhttps://string-db.org/network/511145.b3057Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.
folB protein networkhttps://string-db.org/network/511145.b3058Dihydroneopterin aldolase and dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin [...]
plsY protein networkhttps://string-db.org/network/511145.b3059Putative glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utiliz [...]
ttdR protein networkhttps://string-db.org/network/511145.b3060Transcriptional activator of ttdABT; Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB-ygjE operon.
ttdA protein networkhttps://string-db.org/network/511145.b3061L-tartrate dehydratase, subunit A; Protein involved in fermentation.
ttdB protein networkhttps://string-db.org/network/511145.b3062L-tartrate dehydratase, subunit B; Protein involved in fermentation.
ttdT protein networkhttps://string-db.org/network/511145.b3063L-tartrate/succinate antiporte; Catalyzes the uptake of tartrate in exchange for intracellular succinate. Essential for anaerobic L-tartrate fermentation; Belongs to the SLC13A/DASS transporter ( [...]
tsaD protein networkhttps://string-db.org/network/511145.b3064tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginnin [...]
rpsU protein networkhttps://string-db.org/network/511145.b306530S ribosomal subunit protein S21; Protein involved in structural constituent of ribosome and translation; Belongs to the bacterial ribosomal protein bS21 family.
dnaG protein networkhttps://string-db.org/network/511145.b3066DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
rpoD protein networkhttps://string-db.org/network/511145.b3067RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor [...]
mug protein networkhttps://string-db.org/network/511145.b3068G/U mismatch-specific DNA glycosylase; Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in d [...]
yqjH protein networkhttps://string-db.org/network/511145.b3070Putative siderophore interacting protein; Plays a role in iron homeostasis under excess nickel conditions; Belongs to the SIP oxidoreductase family.
yqjI protein networkhttps://string-db.org/network/511145.b3071PadR family putative transcriptional regulator; Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression.
aer protein networkhttps://string-db.org/network/511145.b3072Fused signal transducer for aerotaxis sensory component/methyl accepting chemotaxis component; Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bub [...]
patA protein networkhttps://string-db.org/network/511145.b3073Putrescine:2-oxoglutaric acid aminotransferase, PLP-dependent; Catalyzes the aminotransferase reaction from putrescine to 2- oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneo [...]
ygjH protein networkhttps://string-db.org/network/511145.b3074Putative tRNA synthetase; Protein involved in tRNA aminoacylation for protein translation.
ebgR protein networkhttps://string-db.org/network/511145.b3075Transcriptional repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer.
ebgA protein networkhttps://string-db.org/network/511145.b3076Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hy [...]
ebgC protein networkhttps://string-db.org/network/511145.b3077Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known.
ygjI protein networkhttps://string-db.org/network/511145.b3078Putative oxidoreductase.
ygjJ protein networkhttps://string-db.org/network/511145.b3079Putative periplasmic protein.
ygjK protein networkhttps://string-db.org/network/511145.b3080Alpha-glucosidase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and [...]
fadH protein networkhttps://string-db.org/network/511145.b30812,4-dienoyl-CoA reductase, NADH and FMN-linked; Functions as an auxiliary enzyme in the beta-oxidation of unsaturated fatty acids with double bonds at even carbon positions. Catalyzes the NADPH-d [...]
higA protein networkhttps://string-db.org/network/511145.b3082Antitoxinof the HigB-HigA toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Functions as an mRNA interferase antitoxin; overexpression prevents HigB-mediated c [...]
higB protein networkhttps://string-db.org/network/511145.b3083mRNA interferase toxin of the HigB-HigA toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-dependent mRNA interferase. Overexpression causes [...]
rlmG protein networkhttps://string-db.org/network/511145.b308423S rRNA m(2)G1835 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
ygjP protein networkhttps://string-db.org/network/511145.b3085Putative metal dependent hydrolase; Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and [...]
ygjQ protein networkhttps://string-db.org/network/511145.b3086DUF218 superfamily protein.
ygjR protein networkhttps://string-db.org/network/511145.b3087Putative NAD(P)-dependent dehydrogenase; Belongs to the Gfo/Idh/MocA family.
alx protein networkhttps://string-db.org/network/511145.b3088Putative membrane-bound redox modulator; Has been proposed to be a redox modulator.
sstT protein networkhttps://string-db.org/network/511145.b3089Sodium:serine/threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
ygjV protein networkhttps://string-db.org/network/511145.b3090Imp-YgjV family inner membrane protein.
uxaA protein networkhttps://string-db.org/network/511145.b3091Altronate hydrolase; Catalyzes the dehydration of D-altronate.
uxaC protein networkhttps://string-db.org/network/511145.b3092Uronate isomerase; Protein involved in carbohydrate catabolic process; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
exuT protein networkhttps://string-db.org/network/511145.b3093Hexuronate transporter; Aldohexuronate transport system.
exuR protein networkhttps://string-db.org/network/511145.b3094Hexuronate regulon transcriptional repressor; Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB operons. Binds D-tagaturo [...]
yqjA protein networkhttps://string-db.org/network/511145.b3095General envelope maintenance protein; May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic [...]
mzrA protein networkhttps://string-db.org/network/511145.b3096Modulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosph [...]
yqjC protein networkhttps://string-db.org/network/511145.b3097DUF1090 family putative periplasmic protein.
yqjD protein networkhttps://string-db.org/network/511145.b3098Membrane-anchored ribosome-binding protein; Upon overexpression inhibits growth.
yqjE protein networkhttps://string-db.org/network/511145.b3099DUF1469 family inner membrane protein.
yqjK protein networkhttps://string-db.org/network/511145.b3100Uncharacterized protein.
yqjF protein networkhttps://string-db.org/network/511145.b3101Putative quinol oxidase subunit.
yqjG protein networkhttps://string-db.org/network/511145.b3102Putative S-transferase; Catalyzes glutathione (GSH)-dependent reduction of glutathionyl-hydroquinones (GS-HQs) to the corresponding hydroquinones. Can use a variety of GS-HQs as substrates, such [...]
yhaH protein networkhttps://string-db.org/network/511145.b3103DUF805 family inner membrane protein; Putative cytochrome.
yhaI protein networkhttps://string-db.org/network/511145.b3104DUF805 family inner membrane protein; Putative cytochrome.
yhaJ protein networkhttps://string-db.org/network/511145.b3105LysR family putative transcriptional regulator; Positive regulator, may be partially responsible for expression of neighboring gene dlsT (yhaO) (By similarity).
yhaK protein networkhttps://string-db.org/network/511145.b3106Redox-sensitive bicupin; Does not have quercetin 2,3-dioxygenase activity. Belongs to the pirin family.
yhaL protein networkhttps://string-db.org/network/511145.b3107Uncharacterized protein.
yhaO protein networkhttps://string-db.org/network/511145.b3110Putative transporter; Plays a role in L-cysteine detoxification. May transport both D- and L-serine (By similarity). Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.
tdcF protein networkhttps://string-db.org/network/511145.b3113Putative reactive intermediate deaminase; May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2- ketobutyrate.
tdcE protein networkhttps://string-db.org/network/511145.b3114Pyruvate formate-lyase 4/2-ketobutyrate formate-lyase; Catalyzes the cleavage of 2-ketobutyrate to propionyl-CoA and formate. It can also use pyruvate as substrate. Belongs to the glycyl radical [...]
tdcD protein networkhttps://string-db.org/network/511145.b3115Propionate kinase/acetate kinase C, anaerobic; Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor; Belongs [...]
tdcC protein networkhttps://string-db.org/network/511145.b3116L-threonine/L-serine transporter; Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system). Belongs to the amino acid/polyamine trans [...]
tdcB protein networkhttps://string-db.org/network/511145.b3117L-threonine dehydratase, catabolic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine a [...]
tdcA protein networkhttps://string-db.org/network/511145.b3118Tdc operon transcriptional activator; Transcriptional activator for the tdcABCDE operon. Belongs to the LysR transcriptional regulatory family.
tdcR protein networkhttps://string-db.org/network/511145.b3119L-threonine dehydratase operon activator protein; Probable trans-acting positive activator for the tdc operon.
yhaB protein networkhttps://string-db.org/network/511145.b3120Uncharacterized protein.
yhaC protein networkhttps://string-db.org/network/511145.b3121Pentapetide repeats-related protein.
garK protein networkhttps://string-db.org/network/511145.b3124Glycerate kinase I; Protein involved in carbohydrate catabolic process; Belongs to the glycerate kinase type-1 family.
garR protein networkhttps://string-db.org/network/511145.b3125Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate.
garL protein networkhttps://string-db.org/network/511145.b3126alpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdeh [...]
garP protein networkhttps://string-db.org/network/511145.b3127Putative (D)-galactarate transporter; Uptake of D-galactarate; Belongs to the major facilitator superfamily. Phthalate permease family.
garD protein networkhttps://string-db.org/network/511145.b3128D-galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate.
prlF protein networkhttps://string-db.org/network/511145.b3129Antitoxin of the SohA(PrlF)-YhaV toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to the YhaV toxin and neutralizes its ribonuclea [...]
yhaV protein networkhttps://string-db.org/network/511145.b3130Toxin of the SohB(PrlF)-YhaV toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity in vitro. Overexpression leads to growth arrest after 30 minutes; [...]
agaR protein networkhttps://string-db.org/network/511145.b3131Transcriptional repressor of the aga regulon; Probable repressor for the aga operon for N-acetyl galactosamine transport and metabolism.
kbaZ protein networkhttps://string-db.org/network/511145.b3132Tagatose 6-phosphate aldolase 1, kbaZ subunit; Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone- [...]
agaV protein networkhttps://string-db.org/network/511145.b3133N-acetylgalactosamine-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes [...]
agaS protein networkhttps://string-db.org/network/511145.b3136Putative D-galactosamine-6-phosphate deaminase AgaS; Catalyzes the isomerization-deamination of galactosamine 6- phosphate to form tagatofuranose 6-phosphate and ammonium ion.
kbaY protein networkhttps://string-db.org/network/511145.b3137Tagatose 6-phosphate aldolase 1, kbaY subunit; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate ( [...]
agaB protein networkhttps://string-db.org/network/511145.b3138N-acetylgalactosamine-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes [...]
agaC protein networkhttps://string-db.org/network/511145.b3139N-acetylgalactosamine-specific enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the p [...]
agaD protein networkhttps://string-db.org/network/511145.b3140N-acetylgalactosamine-specific enzyme IID component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the p [...]
agaI protein networkhttps://string-db.org/network/511145.b3141Putative galactosamine-6-phosphate isomerase; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
yraH protein networkhttps://string-db.org/network/511145.b3142Putative fimbrial-like adhesin protein; Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T2 [...]
yraI protein networkhttps://string-db.org/network/511145.b3143Putative periplasmic pilin chaperone; Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 [...]
yraJ protein networkhttps://string-db.org/network/511145.b3144Putative outer membrane protein; Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladd [...]
yraK protein networkhttps://string-db.org/network/511145.b3145Putative fimbrial-like adhesin protein; Part of the yraHIJK fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T2 [...]
rsmI protein networkhttps://string-db.org/network/511145.b314616S rRNA C1402 2'-O-ribose methyltransferase, SAM-dependent; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. In vitro, active on the assembled 30S subunit, but [...]
lpoA protein networkhttps://string-db.org/network/511145.b3147OM lipoprotein stimulator of MrcA transpeptidase; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Stimulates transpeptidase activ [...]
yraN protein networkhttps://string-db.org/network/511145.b3148UPF0102 family protein; Belongs to the UPF0102 family.
diaA protein networkhttps://string-db.org/network/511145.b3149DnaA initiator-associating factor for replication initiation; Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.
yraP protein networkhttps://string-db.org/network/511145.b3150Outer membrane lipoprotein; Putative periplasmic protein.
yraQ protein networkhttps://string-db.org/network/511145.b3151Putative inner membrane permease.
yraR protein networkhttps://string-db.org/network/511145.b3152Putative nucleoside-diphosphate-sugar epimerase; To yeast YER004W.
yhbO protein networkhttps://string-db.org/network/511145.b3153Stress-resistance protein; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl gro [...]
yhbP protein networkhttps://string-db.org/network/511145.b3154UPF0306 family protein; Belongs to the UPF0306 family.
yhbQ protein networkhttps://string-db.org/network/511145.b3155GIY-YIG nuclease superfamily protein; Belongs to the UPF0213 family.
yhbS protein networkhttps://string-db.org/network/511145.b3156GNAT family putative N-acetyltransferase; Belongs to the acetyltransferase family.
yhbT protein networkhttps://string-db.org/network/511145.b3157SCP-2 sterol transfer family protein; Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.
yhbU protein networkhttps://string-db.org/network/511145.b3158U32 peptidase family protein; Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiq [...]
yhbV protein networkhttps://string-db.org/network/511145.b3159U32 peptidase family protein; Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiq [...]
yhbW protein networkhttps://string-db.org/network/511145.b3160Putative luciferase-like monooxygenase; Putative enzyme; To bacterial alkanal monooxygenase alpha and beta chains.
mtr protein networkhttps://string-db.org/network/511145.b3161Tryptophan transporter of high affinity; Involved in transporting tryptophan across the cytoplasmic membrane.
deaD protein networkhttps://string-db.org/network/511145.b3162ATP-dependent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. Exhibits R [...]
nlpI protein networkhttps://string-db.org/network/511145.b3163Lipoprotein involved in osmotic sensitivity and filamentation; May be involved in cell division. May play a role in bacterial septation or regulation of cell wall degradation during cell division [...]
pnp protein networkhttps://string-db.org/network/511145.b3164Polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. Also involv [...]
rpsO protein networkhttps://string-db.org/network/511145.b316530S ribosomal subunit protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridg [...]
truB protein networkhttps://string-db.org/network/511145.b3166tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
rbfA protein networkhttps://string-db.org/network/511145.b316730s ribosome binding factor; One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late maturation steps of the functional core of the 30S subunit. Essential for efficient [...]
infB protein networkhttps://string-db.org/network/511145.b3168Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. May protect N-formylmethionyl-tRNA(fMet) from spontaneous hydrolysis. Promotes N-formy [...]
nusA protein networkhttps://string-db.org/network/511145.b3169Transcription termination/antitermination L factor; Participates in both transcription termination and antitermination. Involved in a variety of cellular and viral termination and antitermination [...]
rimP protein networkhttps://string-db.org/network/511145.b3170Ribosome maturation factor for 30S subunits; Required for maturation of 30S ribosomal subunits, probably at a late stage of ribosomal protein binding, while Era is associated and after RimM.
argG protein networkhttps://string-db.org/network/511145.b3172Argininosuccinate synthetase; Protein involved in arginine biosynthetic process; Belongs to the argininosuccinate synthase family. Type 2 subfamily.
yhbX protein networkhttps://string-db.org/network/511145.b3173Putative EptAB family phosphoethanolamine transferase, inner membrane protein; Probably does not transfer phosphoethanolamine to lipid A. Belongs to the phosphoethanolamine transferase family.
secG protein networkhttps://string-db.org/network/511145.b3175Preprotein translocase membrane subunit; Subunit of the protein translocation channel SecYEG. Overexpression of some hybrid proteins has been thought to jam the protein secretion apparatus result [...]
glmM protein networkhttps://string-db.org/network/511145.b3176Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. Can also catalyze the formation of glucose-6-P from glucose-1-P, although at a 1400-fold [...]
folP protein networkhttps://string-db.org/network/511145.b31777,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immedi [...]
ftsH protein networkhttps://string-db.org/network/511145.b3178Protease, ATP-dependent zinc-metallo; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membran [...]
rlmE protein networkhttps://string-db.org/network/511145.b317923S rRNA U2552 2'-O-ribose methyltransferase, SAM-dependent; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosom [...]
yhbY protein networkhttps://string-db.org/network/511145.b3180RNA binding protein associated with pre-50S ribosomal subunits.
greA protein networkhttps://string-db.org/network/511145.b3181Transcript cleavage factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certa [...]
dacB protein networkhttps://string-db.org/network/511145.b3182D-alanyl-D-alanine carboxypeptidase; Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction. Belongs to the peptidase S13 family.
obgE protein networkhttps://string-db.org/network/511145.b3183GTPase involved in cell partioning and DNA repair; An abundant, essential GTPase which binds GTP, GDP and ppGpp with moderate affinity. Has high guanosine nucleotide exchange rate constants for G [...]
yhbE protein networkhttps://string-db.org/network/511145.b3184EamA family inner membrane putative transporter; Belongs to the EamA transporter family.
rpmA protein networkhttps://string-db.org/network/511145.b318550S ribosomal subunit protein L27; Protein involved in structural constituent of ribosome and translation.
rplU protein networkhttps://string-db.org/network/511145.b318650S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20.
ispB protein networkhttps://string-db.org/network/511145.b3187Octaprenyl diphosphate synthase; Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone. Belongs to the FPP/GGPP synthase family.
sfsB protein networkhttps://string-db.org/network/511145.b3188malPQ operon transcriptional activator; This protein is involved in positive regulation of the metabolism of sugars.
murA protein networkhttps://string-db.org/network/511145.b3189UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine. Target for the antibiotic fosfomycin; Belongs to the EPSP synthase family. Mur [...]
ibaG protein networkhttps://string-db.org/network/511145.b3190Acid stress protein; Involved in cell resistance against acid stress.
mlaB protein networkhttps://string-db.org/network/511145.b3191ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid [...]
mlaC protein networkhttps://string-db.org/network/511145.b3192ABC transporter maintaining OM lipid asymmetry, periplasmic binding protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde traffi [...]
mlaD protein networkhttps://string-db.org/network/511145.b3193OM lipid asymmetry maintenance protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by [...]
mlaE protein networkhttps://string-db.org/network/511145.b3194ABC transporter maintaining OM lipid asymmetry, inner membrane permease protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains [...]
mlaF protein networkhttps://string-db.org/network/511145.b3195ABC transporter maintaining OM lipid asymmetry, ATP-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymme [...]
yrbG protein networkhttps://string-db.org/network/511145.b3196Putative calcium/sodium:proton antiporter; Protein involved in calcium:sodium antiporter activity.
kdsD protein networkhttps://string-db.org/network/511145.b3197D-arabinose 5-phosphate isomerase; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). KdsD is not essential in th [...]
kdsC protein networkhttps://string-db.org/network/511145.b31983-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate [...]
lptC protein networkhttps://string-db.org/network/511145.b3199Periplasmic membrane-anchored LPS-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facil [...]
lptA protein networkhttps://string-db.org/network/511145.b3200Lipopolysaccharide export ABC transporter periplasmic binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the o [...]
lptB protein networkhttps://string-db.org/network/511145.b3201Lipopolysaccharide export ABC transporter ATPase; Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membran [...]
rpoN protein networkhttps://string-db.org/network/511145.b3202RNA polymerase, sigma 54 (sigma N) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor [...]
hpf protein networkhttps://string-db.org/network/511145.b3203Ribosome hibernation promoting factor HPF; During stationary phase, promotes and stabilizes dimerization of 70S ribosomes by the ribosome modulation factor (RMF), leading to the formation of inac [...]
ptsN protein networkhttps://string-db.org/network/511145.b3204Sugar-specific enzyme IIA component of PTS; Seems to have a role in regulating nitrogen assimilation.
yhbJ protein networkhttps://string-db.org/network/511145.b3205Adaptor protein for GlmZ/GlmY sRNA decay, glucosamine-6-phosphate-regulated; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When gluc [...]
npr protein networkhttps://string-db.org/network/511145.b3206Phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr); Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen [...]
yrbL protein networkhttps://string-db.org/network/511145.b3207Mg(2+)-starvation-stimulated protein.
mtgA protein networkhttps://string-db.org/network/511145.b3208Biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors. May play a role in peptidoglycan assembly during cell di [...]
elbB protein networkhttps://string-db.org/network/511145.b3209Isoprenoid biosynthesis protein with amidotransferase-like domain; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate. However, this apparent glyoxalase activity may [...]
arcB protein networkhttps://string-db.org/network/511145.b3210Aerobic respiration control sensor protein ArcB; Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via [...]
yhcC protein networkhttps://string-db.org/network/511145.b3211Putative Fe-S oxidoreductase, Radical SAM superfamily protein; In vitro, can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH); Belongs to the radical SAM superfamily.
gltB protein networkhttps://string-db.org/network/511145.b3212Glutamate synthase, large subunit; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate.
gltD protein networkhttps://string-db.org/network/511145.b3213Glutamate synthase, 4Fe-4S protein, small subunit; Catalyzes the conversion of L-glutamine and 2-oxoglutarate into two molecules of L-glutamate.
gltF protein networkhttps://string-db.org/network/511145.b3214Periplasmic protein; Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression o [...]
yhcA protein networkhttps://string-db.org/network/511145.b3215Putative periplasmic chaperone protein; Could be required for the biogenesis of a putative fimbria. Belongs to the periplasmic pilus chaperone family.
yhcD protein networkhttps://string-db.org/network/511145.b3216Putative outer membrane fimbrial subunit usher protein; Involved in the export and assembly of a fimbrial subunit across the outer membrane; Belongs to the fimbrial export usher family.
insH1-10 protein networkhttps://string-db.org/network/511145.b3218Pseudogene fragment; interrupted by IS5.
yhcF protein networkhttps://string-db.org/network/511145.b3219Putative transcriptional regulator; Protein involved in transcription and regulation of transcription, DNA-dependent; To E.coli GltF.
yhcG protein networkhttps://string-db.org/network/511145.b3220DUF1016 family protein in the PD-(D/E)XK nuclease superfamily; May be a nuclease involved in DNA recombination and repair.
yhcH protein networkhttps://string-db.org/network/511145.b3221DUF386 family protein, cupin superfamily.
nanK protein networkhttps://string-db.org/network/511145.b3222N-acetylmannosamine kinase; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. Has also low level glucokinase activity in vitro. Belongs to the ROK (NagC/XylR) family. N [...]
nanE protein networkhttps://string-db.org/network/511145.b3223Putative N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
nanT protein networkhttps://string-db.org/network/511145.b3224Sialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Can transport the common sialic acid N-acetylneuraminic acid (Neu5Ac) and the related sialic acids N- glycolylneu [...]
nanA protein networkhttps://string-db.org/network/511145.b3225N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediat [...]
nanR protein networkhttps://string-db.org/network/511145.b3226Sialic acid-inducible nan operon repressor; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids. Represses expression of the nanATEK- yhcH, [...]
dcuD protein networkhttps://string-db.org/network/511145.b3227Putative transporter; May have a role in the transport of dicarboxylates from the periplasm across the inner membrane. Seems not to be essential for growth. It is likely to be a cryptic gene, as [...]
sspB protein networkhttps://string-db.org/network/511145.b3228ClpXP protease specificity enhancing factor; Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans- translationally to prot [...]
sspA protein networkhttps://string-db.org/network/511145.b3229Stringent starvation protein A; Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme. It is synthesized predominantly when cells are exposed to amino [...]
rpsI protein networkhttps://string-db.org/network/511145.b323030S ribosomal subunit protein S9; The C-terminal tail plays a role in the affinity of the 30S P site for different tRNAs. Mutations that decrease this affinity are suppressed in the 70S ribosome.
rplM protein networkhttps://string-db.org/network/511145.b323150S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the earl [...]
zapE protein networkhttps://string-db.org/network/511145.b3232Divisome ATPase; Reduces the stability of FtsZ polymers in the presence of ATP. Required for cell division under low-oxygen conditions. Hydrolyzes ATP but not GTP.
yhcB protein networkhttps://string-db.org/network/511145.b3233DUF1043 family inner membrane-anchored protein.
degQ protein networkhttps://string-db.org/network/511145.b3234Serine endoprotease, periplasmic; DegQ could degrade transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions. DegQ is efficient with Val-Xaa and [...]
degS protein networkhttps://string-db.org/network/511145.b3235Serine endoprotease, periplasmic; A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When [...]
mdh protein networkhttps://string-db.org/network/511145.b3236Malate dehydrogenase, NAD(P)-binding; Catalyzes the reversible oxidation of malate to oxaloacetate.
argR protein networkhttps://string-db.org/network/511145.b3237L-arginine-responsive arginine metabolism regulon transcriptional regulator; Negatively controls the expression of the four operons of arginine biosynthesis in addition to the carAB operon. Predo [...]
yhcN protein networkhttps://string-db.org/network/511145.b3238Cadmium and peroxide resistance protein, stress-induced.
yhcO protein networkhttps://string-db.org/network/511145.b3239Putative barnase inhibitor; Belongs to the barstar family.
aaeB protein networkhttps://string-db.org/network/511145.b3240P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high lev [...]
aaeA protein networkhttps://string-db.org/network/511145.b3241P-hydroxybenzoic acid efflux system component; Forms an efflux pump with AaeB.
aaeX protein networkhttps://string-db.org/network/511145.b3242DUF1656 family putative inner membrane efflux pump associated protein; Belongs to the AaeX family.
aaeR protein networkhttps://string-db.org/network/511145.b3243Transcriptional regulator for aaeXAB operon; Activates transcription of the aaeXAB operon.
tldD protein networkhttps://string-db.org/network/511145.b3244Putative peptidase; Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA). Belongs to the peptidase U62 family.
rng protein networkhttps://string-db.org/network/511145.b3247Ribonuclease G; Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filam [...]
yhdE protein networkhttps://string-db.org/network/511145.b3248dTTP/UTP pyrophosphatase; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze TTP and the modified nucleotides 5-methyl-UTP (m(5)UTP), pseudo-UTP and 5-methyl [...]
mreD protein networkhttps://string-db.org/network/511145.b3249Cell wall structural complex MreBCD transmembrane component MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins [...]
mreC protein networkhttps://string-db.org/network/511145.b3250Cell wall structural complex MreBCD transmembrane component MreC; Involved in formation and maintenance of cell shape. Responsible for formation of rod shape. May also contribute to regulation of [...]
mreB protein networkhttps://string-db.org/network/511145.b3251Cell wall structural complex MreBCD, actin-like component MreB; Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis [...]
csrD protein networkhttps://string-db.org/network/511145.b3252Targeting factor for csrBC sRNA degradation; Serves as a specificity factor required for RNase E-mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. N [...]
acuI protein networkhttps://string-db.org/network/511145.b3253Putative acryloyl-CoA reductase; Probably catalyzes the NADPH-dependent reduction of acrylyl- CoA to propanoyl-CoA; Belongs to the zinc-containing alcohol dehydrogenase family. Acrylyl-CoA reduct [...]
accB protein networkhttps://string-db.org/network/511145.b3255Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the c [...]
accC protein networkhttps://string-db.org/network/511145.b3256acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier [...]
yhdT protein networkhttps://string-db.org/network/511145.b3257DUF997 family putative inner membrane protein; To H.influenzae HI_0974B.
panF protein networkhttps://string-db.org/network/511145.b3258Pantothenate:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular pantothenate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
prmA protein networkhttps://string-db.org/network/511145.b3259Methyltransferase for 50S ribosomal subunit protein L11; Methylates ribosomal protein L11.
dusB protein networkhttps://string-db.org/network/511145.b3260tRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines [...]
fis protein networkhttps://string-db.org/network/511145.b3261Global DNA-binding transcriptional dual regulator; Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinati [...]
yhdJ protein networkhttps://string-db.org/network/511145.b3262DNA adenine methyltransferase, SAM-dependent; Methylates the second adenine of the NsiI recognition sequence (5'-ATGCAT-3').
yhdU protein networkhttps://string-db.org/network/511145.b3263Putative membrane protein.
acrS protein networkhttps://string-db.org/network/511145.b3264acrAB operon transcriptional repressor; Potential regulator protein for the acrEF/envCD genes.
acrE protein networkhttps://string-db.org/network/511145.b3265Cytoplasmic membrane lipoprotein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the membrane fusion protein (MFP) (TC 8.A.1) f [...]
acrF protein networkhttps://string-db.org/network/511145.b3266Multidrug efflux system protein; Part of the tripartite efflux system AcrEF-TolC. Involved in the efflux of indole and organic solvents. Belongs to the resistance-nodulation-cell division (RND) ( [...]
yhdV protein networkhttps://string-db.org/network/511145.b3267Putative outer membrane protein.
yhdX protein networkhttps://string-db.org/network/511145.b3269Putative amino-acid ABC transporter permease protein YhdX; Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of [...]
yhdY protein networkhttps://string-db.org/network/511145.b3270Putative amino acid ABC transporter permease; Probably part of the binding-protein-dependent transport system YdhWXYZ for an amino acid; probably responsible for the translocation of the substrat [...]
yhdZ protein networkhttps://string-db.org/network/511145.b3271Putative amino acid ABC transporter ATPase; Probably part of a binding-protein-dependent transport system YdhWXYZ for an amino acid. Probably responsible for energy coupling to the transport syst [...]
yrdA protein networkhttps://string-db.org/network/511145.b3279Bacterial transferase hexapeptide domain protein; Putative transferase; Belongs to the gamma-class carbonic anhydrase family.
yrdB protein networkhttps://string-db.org/network/511145.b3280DUF1488 family protein.
aroE protein networkhttps://string-db.org/network/511145.b3281Dehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reductio [...]
tsaC protein networkhttps://string-db.org/network/511145.b3282Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conve [...]
yrdD protein networkhttps://string-db.org/network/511145.b3283ssDNA-binding protein, function unknown; Putative DNA topoisomerase; To H.influenzae HI_0656.1.
smg protein networkhttps://string-db.org/network/511145.b3284DUF494 family putative periplasmic protein; Belongs to the Smg family.
def protein networkhttps://string-db.org/network/511145.b3287Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a [...]
fmt protein networkhttps://string-db.org/network/511145.b328810-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the [...]
rsmB protein networkhttps://string-db.org/network/511145.b328916S rRNA m(5)C967 methyltransferase, SAM-dependent; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
trkA protein networkhttps://string-db.org/network/511145.b3290NAD-binding component of TrK potassium transporter; Part of the constitutive potassium transport systems TrkG and TrkH. May regulate the transport activity of TrkG and TrkH systems. Binds to NAD( [...]
mscL protein networkhttps://string-db.org/network/511145.b3291Mechanosensitive channel protein, high conductance; Mechanosensitive channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conduc [...]
zntR protein networkhttps://string-db.org/network/511145.b3292zntA gene transcriptional activator; Zinc-responsive transcriptional regulator of zntA.
yhdN protein networkhttps://string-db.org/network/511145.b3293DUF1992 family protein.
rplQ protein networkhttps://string-db.org/network/511145.b329450S ribosomal subunit protein L17; Requires L15 for assembly into the 50S subunit.
rpoA protein networkhttps://string-db.org/network/511145.b3295RNA polymerase, alpha subunit; DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an imp [...]
rpsD protein networkhttps://string-db.org/network/511145.b329630S ribosomal subunit protein S4; One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Plays a rol [...]
rpsK protein networkhttps://string-db.org/network/511145.b329730S ribosomal subunit protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosom [...]
rpsM protein networkhttps://string-db.org/network/511145.b329830S ribosomal subunit protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. Contacts the tRNAs in the A and P sites. Belongs to the univers [...]
rpmJ protein networkhttps://string-db.org/network/511145.b329950S ribosomal subunit protein L36; Protein involved in structural constituent of ribosome and translation; Belongs to the bacterial ribosomal protein bL36 family.
secY protein networkhttps://string-db.org/network/511145.b3300Preprotein translocase membrane subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate [...]
rplO protein networkhttps://string-db.org/network/511145.b330150S ribosomal subunit protein L15; This protein binds the 5S rRNA. It is required for the late stages of subunit assembly, and is essential for 5S rRNA assembly onto the ribosome; Belongs to the [...]
rpmD protein networkhttps://string-db.org/network/511145.b330250S ribosomal subunit protein L30; Protein involved in structural constituent of ribosome and translation.
rpsE protein networkhttps://string-db.org/network/511145.b330330S ribosomal subunit protein S5; With S4 and S12 plays an important role in translational accuracy. Many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, s [...]
rplR protein networkhttps://string-db.org/network/511145.b330450S ribosomal subunit protein L18; This is one of the proteins that mediates the attachment of the 5S rRNA subcomplex onto the large ribosomal subunit where it forms part of the central protubera [...]
rplF protein networkhttps://string-db.org/network/511145.b330550S ribosomal subunit protein L6; This protein binds directly to at least 2 domains of the 23S ribosomal RNA, thus is important in its secondary structure. It is located near the subunit interfac [...]
rpsH protein networkhttps://string-db.org/network/511145.b330630S ribosomal subunit protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Bel [...]
rpsN protein networkhttps://string-db.org/network/511145.b330730S ribosomal subunit protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
rplE protein networkhttps://string-db.org/network/511145.b330850S ribosomal subunit protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central prot [...]
rplX protein networkhttps://string-db.org/network/511145.b330950S ribosomal subunit protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. It is not thought to be [...]
rplN protein networkhttps://string-db.org/network/511145.b331050S ribosomal subunit protein L14; This protein binds directly to 23S ribosomal RNA. In the E.coli 70S ribosome it has been modeled to make two contacts with the 16S rRNA of the 30S subunit, form [...]
rpsQ protein networkhttps://string-db.org/network/511145.b331130S ribosomal subunit protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. Also plays a role in translational accuracy; neamine-resista [...]
rpmC protein networkhttps://string-db.org/network/511145.b331250S ribosomal subunit protein L29; Binds 23S rRNA. It is not essential for growth.
rplP protein networkhttps://string-db.org/network/511145.b331350S ribosomal subunit protein L16; This protein binds directly to 23S ribosomal RNA and is located at the A site of the peptidyltransferase center. It contacts the A and P site tRNAs. It has an e [...]
rpsC protein networkhttps://string-db.org/network/511145.b331430S ribosomal subunit protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity). Belongs to the universal ribosomal [...]
rplV protein networkhttps://string-db.org/network/511145.b331550S ribosomal subunit protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stag [...]
rpsS protein networkhttps://string-db.org/network/511145.b331630S ribosomal subunit protein S19; In the E.coli 70S ribosome in the initiation state it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is br [...]
rplB protein networkhttps://string-db.org/network/511145.b331750S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Located near the base of the L1 stalk, it is probably also mobile. Required for association of the 30S and 50S subunits [...]
rplW protein networkhttps://string-db.org/network/511145.b331850S ribosomal subunit protein L23; One of the early assembly proteins, it binds 23S rRNA; is essential for growth. One of the proteins that surround the polypeptide exit tunnel on the outside of [...]
rplD protein networkhttps://string-db.org/network/511145.b331950S ribosomal subunit protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. [...]
rplC protein networkhttps://string-db.org/network/511145.b332050S ribosomal subunit protein L3; One of two assembly initiator proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
rpsJ protein networkhttps://string-db.org/network/511145.b332130S ribosomal subunit protein S10; Involved in the binding of tRNA to the ribosomes. In addition, in complex with NusB, is involved in the regulation of ribosomal RNA (rRNA) biosynthesis by trans [...]
gspB protein networkhttps://string-db.org/network/511145.b3322Part of gsp divergon involved in type II protein secretion; Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain [...]
gspA protein networkhttps://string-db.org/network/511145.b3323General secretory pathway component, cryptic; May play a regulatory role under conditions of derepressed gsp gene expression; Belongs to the ExeA family.
gspC protein networkhttps://string-db.org/network/511145.b3324General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspD protein networkhttps://string-db.org/network/511145.b3325General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane. T [...]
gspE protein networkhttps://string-db.org/network/511145.b3326General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspF protein networkhttps://string-db.org/network/511145.b3327General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspG protein networkhttps://string-db.org/network/511145.b3328Pseudopilin, cryptic, general secretion pathway; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspH protein networkhttps://string-db.org/network/511145.b3329Putative general secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspI protein networkhttps://string-db.org/network/511145.b3330General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspJ protein networkhttps://string-db.org/network/511145.b3331Putative general secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspK protein networkhttps://string-db.org/network/511145.b3332General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Belongs to the GSP K family.
gspL protein networkhttps://string-db.org/network/511145.b3333General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspM protein networkhttps://string-db.org/network/511145.b3334General secretory pathway component, cryptic; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.
gspO protein networkhttps://string-db.org/network/511145.b3335Bifunctional prepilin leader peptidase/ methylase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
bfr protein networkhttps://string-db.org/network/511145.b3336Bacterioferritin, iron storage and detoxification protein; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequen [...]
bfd protein networkhttps://string-db.org/network/511145.b3337Bacterioferritin-associated ferredoxin; Seems to associate with BFR; could be a general redox and/or regulatory component participating in the iron storage mobilization functions of BFR. Could pa [...]
chiA protein networkhttps://string-db.org/network/511145.b3338Periplasmic endochitinase; Bifunctional enzyme with lysozyme/chitinase activity.
tufA protein networkhttps://string-db.org/network/511145.b3339Translation elongation factor EF-Tu 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans [...]
fusA protein networkhttps://string-db.org/network/511145.b3340Protein chain elongation factor EF-G, GTP-binding; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-tran [...]
rpsG protein networkhttps://string-db.org/network/511145.b334130S ribosomal subunit protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subu [...]
rpsL protein networkhttps://string-db.org/network/511145.b334230S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy. Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-reco [...]
tusB protein networkhttps://string-db.org/network/511145.b3343mnm(5)-s(2)U34-tRNA synthesis 2-thiolation protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
tusC protein networkhttps://string-db.org/network/511145.b3344mnm(5)-s(2)U34-tRNA synthesis 2-thiolation protein; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
tusD protein networkhttps://string-db.org/network/511145.b3345Sulfurtransferase for 2-thiolation step of mnm(5)-s(2)U34-tRNA synthesis; Part of a sulfur-relay system required for 2-thiolation of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobbl [...]
yheO protein networkhttps://string-db.org/network/511145.b3346Putative PAS domain-containing DNA-binding transcriptional regulator; To H.influenzae HI_0575.
fkpA protein networkhttps://string-db.org/network/511145.b3347FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
slyX protein networkhttps://string-db.org/network/511145.b3348Host factor for lysis of phiX174 infection; Belongs to the SlyX family.
slyD protein networkhttps://string-db.org/network/511145.b3349FKBP-type peptidyl prolyl cis-trans isomerase (rotamase); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation [...]
kefB protein networkhttps://string-db.org/network/511145.b3350Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. Belongs to the monovalent cation:proton [...]
kefG protein networkhttps://string-db.org/network/511145.b3351Potassium-efflux system ancillary protein for KefB, glutathione-regulated; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activit [...]
yheS protein networkhttps://string-db.org/network/511145.b3352ABC-F family protein predicted regulatory ATPase; Genetic data indicate it may be involved in ribosome assembly or function; Belongs to the ABC transporter superfamily. ABCF family. YheS subfamil [...]
yheT protein networkhttps://string-db.org/network/511145.b3353UPF0017 family putative hydrolase; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
yheU protein networkhttps://string-db.org/network/511145.b3354UPF0270 family protein; Belongs to the UPF0270 family.
prkB protein networkhttps://string-db.org/network/511145.b3355Probable phosphoribulokinase; Protein involved in glucose metabolic process.
yhfA protein networkhttps://string-db.org/network/511145.b3356OsmC family protein.
crp protein networkhttps://string-db.org/network/511145.b3357cAMP-activated global transcription factor, mediator of catabolite repression; A global transcription regulator. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to co [...]
yhfK protein networkhttps://string-db.org/network/511145.b3358Putative transporter, FUSC superfamily inner membrane protein; Protein involved in metabolic process.
argD protein networkhttps://string-db.org/network/511145.b3359Bifunctional acetylornithine aminotransferase and succinyldiaminopimelate aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phos [...]
pabA protein networkhttps://string-db.org/network/511145.b3360Aminodeoxychorismate synthase, subunit II; Part of a heterodimeric complex that catalyzes the two-step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p- aminobenzoate (PABA) and [...]
fic protein networkhttps://string-db.org/network/511145.b3361Stationary phase-induced protein, putative toxin; Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (By similarit [...]
yhfG protein networkhttps://string-db.org/network/511145.b3362Putative antitoxin for Fic.
ppiA protein networkhttps://string-db.org/network/511145.b3363Peptidyl-prolyl cis-trans isomerase A (rotamase A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs [...]
tsgA protein networkhttps://string-db.org/network/511145.b3364Putative transport; Belongs to the major facilitator superfamily. TsgA family.
nirB protein networkhttps://string-db.org/network/511145.b3365Nitrite reductase, large subunit, NAD(P)H-binding; Nitrite reductase (NAD(P)H) subunit; Protein involved in anaerobic respiration; Belongs to the nitrite and sulfite reductase 4Fe-4S domain famil [...]
nirD protein networkhttps://string-db.org/network/511145.b3366Nitrite reductase (NADH) small subunit; Required for activity of the reductase. To B.subtilis NasE.
nirC protein networkhttps://string-db.org/network/511145.b3367Nitrite transporter; Catalyzes nitrite uptake and nitrite export across the cytoplasmic membrane. Is up to 10-fold more active than NarK or NarU in nitrite uptake for subsequent reduction in the [...]
cysG protein networkhttps://string-db.org/network/511145.b3368Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. [...]
yhfL protein networkhttps://string-db.org/network/511145.b3369Small lipoprotein.
frlA protein networkhttps://string-db.org/network/511145.b3370Putative fructoselysine transporter; Is likely involved in the transport of fructoselysine and psicoselysine to the cytoplasm, where they are degraded.
frlB protein networkhttps://string-db.org/network/511145.b3371fructoselysine-6-P-deglycase; Catalyzes the reversible conversion of fructoselysine 6- phosphate to glucose 6-phosphate and lysine. Functions in a fructoselysine degradation pathway that allows E [...]
frlD protein networkhttps://string-db.org/network/511145.b3374Fructoselysine 6-kinase; Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow [...]
frlR protein networkhttps://string-db.org/network/511145.b3375Putative DNA-binding transcriptional regulator; May regulate the transcription of the frlABCDR operon, involved in the utilization of fructoselysine and psicoselysine.
yhfS protein networkhttps://string-db.org/network/511145.b3376FNR-regulated pyridoxal phosphate-dependent aminotransferase family protein.
yhfT protein networkhttps://string-db.org/network/511145.b3377Inner membrane protein; Putative transport system permease protein.
yhfU protein networkhttps://string-db.org/network/511145.b3378DUF2620 family protein.
php protein networkhttps://string-db.org/network/511145.b3379Phosphotriesterase homology protein; Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesteras [...]
yhfW protein networkhttps://string-db.org/network/511145.b3380Phosphopentomutase-related metalloenzyme superfamily protein; Putative mutase.
yhfX protein networkhttps://string-db.org/network/511145.b3381Putative pyridoxal 5'-phosphate binding protein.
yhfY protein networkhttps://string-db.org/network/511145.b3382PRD domain protein.
yhfZ protein networkhttps://string-db.org/network/511145.b3383Putative DNA-binding transcriptional regulator.
trpS protein networkhttps://string-db.org/network/511145.b3384tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Amino acylates tRNA(Trp) with both L- and D-tryptophan, although D-tryptophan is a poor substrate ; Belongs to t [...]
gph protein networkhttps://string-db.org/network/511145.b3385Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate (2P-Gly). Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during [...]
rpe protein networkhttps://string-db.org/network/511145.b3386D-ribulose-5-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate.
dam protein networkhttps://string-db.org/network/511145.b3387DNA adenine methyltransferase; Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a numb [...]
damX protein networkhttps://string-db.org/network/511145.b3388Cell division protein that binds to the septal ring; Non-essential cell division protein. Belongs to the DamX family.
aroB protein networkhttps://string-db.org/network/511145.b33893-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
aroK protein networkhttps://string-db.org/network/511145.b3390Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Belongs to the shikimate kinase family.
hofQ protein networkhttps://string-db.org/network/511145.b3391DNA catabolic putative fimbrial transporter; Required for the use of extracellular DNA as a nutrient. Could be the porin responsible for transport of DNA across the outer membrane.
hofP protein networkhttps://string-db.org/network/511145.b3392DNA catabolic protein; Required for the use of extracellular DNA as a nutrient.
hofO protein networkhttps://string-db.org/network/511145.b3393DNA catabolic protein; Required for the use of extracellular DNA as a nutrient.
hofN protein networkhttps://string-db.org/network/511145.b3394DNA catabolic putative fimbrial assembly protein; Required for the use of extracellular DNA as a nutrient.
hofM protein networkhttps://string-db.org/network/511145.b3395DNA catabolic putative pilus assembly protein; Required for the use of extracellular DNA as a nutrient.
mrcA protein networkhttps://string-db.org/network/511145.b3396Penicillin-binding protein 1a, murein transglycosylase and transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-i [...]
nudE protein networkhttps://string-db.org/network/511145.b3397Adenosine nucleotide hydrolase; Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP- ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A); Belongs to the Nudix hydrolase family.
yrfF protein networkhttps://string-db.org/network/511145.b3398Putative RcsCDB-response attenuator, inner membrane protein; Putative dehydrogenase.
yrfG protein networkhttps://string-db.org/network/511145.b3399GMP/IMP nucleotidase; Catalyzes the dephosphorylation of different purine nucleotides (GMP and IMP). Also hydrolyzes flavin mononucleotide (FMN). Belongs to the HAD-like hydrolase superfamily.
hslR protein networkhttps://string-db.org/network/511145.b3400Ribosome-associated heat shock protein Hsp15; Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high [...]
hslO protein networkhttps://string-db.org/network/511145.b3401Heat shock protein Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bac [...]
yhgE protein networkhttps://string-db.org/network/511145.b3402DUF4153 family putative inner membrane protein; Putative transport.
pck protein networkhttps://string-db.org/network/511145.b3403Phosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between th [...]
envZ protein networkhttps://string-db.org/network/511145.b3404Sensory histidine kinase in two-component regulatory system with OmpR; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as [...]
ompR protein networkhttps://string-db.org/network/511145.b3405Response regulator in two-component regulatory system with EnvZ; Member of the two-component regulatory system EnvZ/OmpR involved in osmoregulation (particularly of genes ompF and ompC) as well a [...]
greB protein networkhttps://string-db.org/network/511145.b3406Transcript cleavage factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certa [...]
yhgF protein networkhttps://string-db.org/network/511145.b3407Putative transcriptional accessory protein.
feoA protein networkhttps://string-db.org/network/511145.b3408Ferrous iron transporter, protein A; Involved in Fe(2+) ion uptake. Does not stimulate the GTPase activity of the N-terminus of FeoB (residues 1- 276).
feoB protein networkhttps://string-db.org/network/511145.b3409Ferrous iron transporter protein B and GTP-binding protein; Transporter of a GTP-driven Fe(2+) uptake system, probably couples GTP-binding to channel opening and Fe(2+) uptake. A guanine nucleoti [...]
feoC protein networkhttps://string-db.org/network/511145.b3410Putative DNA-binding transcriptional regulator; May function as a transcriptional regulator that controls feoABC expression; Belongs to the FeoC family.
yhgA protein networkhttps://string-db.org/network/511145.b3411Transposase_31 family protein; A low activity DNA endonuclease yielding 3'-hydroxyl ends, equally active on ss or dsDNA, not active on dsRNA. Shows no sequence specificity. Upon expression enhanc [...]
bioH protein networkhttps://string-db.org/network/511145.b3412pimeloyl-ACP methyl ester carboxylesterase; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl- [...]
gntX protein networkhttps://string-db.org/network/511145.b3413DNA catabolic protein; Required for the use of extracellular DNA as a nutrient. Has been suggested to be involved in gluconate metabolism ; Belongs to the ComF/GntX family.
nfuA protein networkhttps://string-db.org/network/511145.b3414Fe/S biogenesis protein, putative scaffold/chaperone protein; Involved in iron-sulfur cluster biogenesis under severe conditions such as iron starvation or oxidative stress. Binds a 4Fe-4S cluste [...]
gntT protein networkhttps://string-db.org/network/511145.b3415Gluconate transporter, high-affinity GNT I system; Part of the gluconate utilization system Gnt-I; high-affinity intake of gluconate.
malQ protein networkhttps://string-db.org/network/511145.b34164-alpha-glucanotransferase (amylomaltase); Protein involved in carbohydrate catabolic process and polysaccharide catabolic process; Belongs to the disproportionating enzyme family.
malP protein networkhttps://string-db.org/network/511145.b3417Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural s [...]
malT protein networkhttps://string-db.org/network/511145.b3418Mal regulon transcriptional activator; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Spec [...]
rtcB protein networkhttps://string-db.org/network/511145.b3421RNA-splicing ligase; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts a [...]
rtcR protein networkhttps://string-db.org/network/511145.b3422Sigma 54-dependent transcriptional regulator of rtcBA expression; Transcriptional repressor of the rtcAB genes. Interacts with sigma-54.
glpG protein networkhttps://string-db.org/network/511145.b3424Rhomboid protease GlpG; Rhomboid-type serine protease that catalyzes intramembrane proteolysis.
glpE protein networkhttps://string-db.org/network/511145.b3425Thiosulfate:cyanide sulfurtransferase (rhodanese); Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. The relatively low affinity of GlpE for both [...]
glpD protein networkhttps://string-db.org/network/511145.b3426Sn-glycerol-3-phosphate dehydrogenase, aerobic, FAD/NAD(P)-binding; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor.
glgP protein networkhttps://string-db.org/network/511145.b3428Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural subst [...]
glgA protein networkhttps://string-db.org/network/511145.b3429Glycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose.
glgC protein networkhttps://string-db.org/network/511145.b3430Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between AT [...]
glgX protein networkhttps://string-db.org/network/511145.b3431Glycogen debranching enzyme; Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin. Shows only [...]
glgB protein networkhttps://string-db.org/network/511145.b34321,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains [...]
asd protein networkhttps://string-db.org/network/511145.b3433Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate.
yhgN protein networkhttps://string-db.org/network/511145.b3434UPF0056 family inner membrane protein.
gntK protein networkhttps://string-db.org/network/511145.b3437Gluconokinase 2, thermoresistant; gluconate transport, GNT I system; Protein involved in glucose metabolic process; Belongs to the gluconokinase GntK/GntV family.
gntR protein networkhttps://string-db.org/network/511145.b3438D-gluconate inducible gluconate regulon transcriptional repressor; Negative regulator for the gluconate utilization system GNT- I, the gntUKR operon.
yhhW protein networkhttps://string-db.org/network/511145.b3439Quercetinase activity in vitro; Has quercetin 2,3-dioxygenase activity in vitro. Its physiological role is unknown; however, may provide a mechanism that would avoid inhibition of key cellular pr [...]
yhhX protein networkhttps://string-db.org/network/511145.b3440Putative regulator; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.
yhhY protein networkhttps://string-db.org/network/511145.b3441Aminoacyl nucleotide detoxifying acetyltransferase; Catalyzes the N-acetylation of L-phenylalanine and L- methionine using acetyl-CoA as acetyl donor in vitro. Cannot accept L- tyrosine as substr [...]
yhhZ protein networkhttps://string-db.org/network/511145.b3442Putative Hcp1 family polymorphic toxin protein; putative colicin-like DNase/tRNase activity; Belongs to the hcp1 family.
insA-5 protein networkhttps://string-db.org/network/511145.b3444Pseudogene, interrupted by IS1E.
insB1-6 protein networkhttps://string-db.org/network/511145.b3445IS1 transposase B.
yrhB protein networkhttps://string-db.org/network/511145.b3446Stable heat shock chaperone.
ggt protein networkhttps://string-db.org/network/511145.b3447Gamma-glutamyltranspeptidase; Cleaves the gamma-glutamyl bond of periplasmic glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutath [...]
yhhA protein networkhttps://string-db.org/network/511145.b3448DUF2756 family protein.
ugpQ protein networkhttps://string-db.org/network/511145.b3449Glycerophosphodiester phosphodiesterase, cytosolic; Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols.
ugpC protein networkhttps://string-db.org/network/511145.b3450Sn-glycerol-3-phosphate ABC transporter ATPase; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system (P [...]
ugpE protein networkhttps://string-db.org/network/511145.b3451Sn-glycerol-3-phosphate ABC transporter permease; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate a [...]
ugpA protein networkhttps://string-db.org/network/511145.b3452Sn-glycerol-3-phosphate ABC transporter permease; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate a [...]
ugpB protein networkhttps://string-db.org/network/511145.b3453Sn-glycerol-3-phosphate ABC transporter periplasmic binding protein; sn-glycerol-3-phosphate and glycerophosphoryl diester-binding protein interacts with the binding protein-dependent transport s [...]
livF protein networkhttps://string-db.org/network/511145.b3454Branched-chain amino acid ABC transporter ATPase; Component of the leucine-specific transport system.
livG protein networkhttps://string-db.org/network/511145.b3455Branched-chain amino acid ABC transporter ATPase; Component of the leucine-specific transport system.
livM protein networkhttps://string-db.org/network/511145.b3456Branched-chain amino acid ABC transporter permease; Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substr [...]
livH protein networkhttps://string-db.org/network/511145.b3457Branched-chain amino acid ABC transporter permease; Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substr [...]
livK protein networkhttps://string-db.org/network/511145.b3458Leucine transporter subunit; This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affi [...]
panM protein networkhttps://string-db.org/network/511145.b3459PanD autocleavage accelerator, panothenate synthesis; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ l [...]
livJ protein networkhttps://string-db.org/network/511145.b3460Branched-chain amino acid ABC transporter periplasmic binding protein; This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two peripl [...]
rpoH protein networkhttps://string-db.org/network/511145.b3461RNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor [...]
ftsX protein networkhttps://string-db.org/network/511145.b3462Putative ABC transporter permease; Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring. Encoded in an operon consisting of gene [...]
ftsE protein networkhttps://string-db.org/network/511145.b3463Cell division ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.
ftsY protein networkhttps://string-db.org/network/511145.b3464Signal Recognition Particle (SRP) receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal [...]
rsmD protein networkhttps://string-db.org/network/511145.b346516S rRNA m(2)G966 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.
yhhL protein networkhttps://string-db.org/network/511145.b3466DUF1145 family protein.
yhhM protein networkhttps://string-db.org/network/511145.b3467DUF2500 family protein; Putative receptor.
yhhN protein networkhttps://string-db.org/network/511145.b3468TMEM86 family putative inner membrane protein; Putative enzyme.
zntA protein networkhttps://string-db.org/network/511145.b3469Zinc, cobalt and lead efflux system; Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead, with highest activity when the metals ar [...]
tusA protein networkhttps://string-db.org/network/511145.b3470mnm(5)-s(2)U34-tRNA 2-thiolation sulfurtransferase; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of [...]
yhhQ protein networkhttps://string-db.org/network/511145.b3471DUF165 family inner membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ(0)) and 7-aminomethyl-7-deazagu [...]
dcrB protein networkhttps://string-db.org/network/511145.b3472Putative lipoprotein; Required for phage C1 adsorption.
yhhS protein networkhttps://string-db.org/network/511145.b3473Putative arabinose efflux transporter; Confers high-level resistance to glyphosate when overexpressed. Overexpression has no effect on intracellular arabinose concentrations. Belongs to the major [...]
yhhT protein networkhttps://string-db.org/network/511145.b3474UPF0118 family putative transporter.
acpT protein networkhttps://string-db.org/network/511145.b34754'-phosphopantetheinyl transferase; May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis in E.coli. The native apo-protein substrate is unknown. Is ab [...]
nikA protein networkhttps://string-db.org/network/511145.b3476Nickel/heme ABC transporter periplasmic binding protein; Involved in a nickel transport system, probably represents the nickel binder.
nikB protein networkhttps://string-db.org/network/511145.b3477Nickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane.
nikC protein networkhttps://string-db.org/network/511145.b3478Nickel ABC transporter permease; Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane.
nikD protein networkhttps://string-db.org/network/511145.b3479Nickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter supe [...]
nikE protein networkhttps://string-db.org/network/511145.b3480Nickel ABC transporter ATPase; Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter supe [...]
nikR protein networkhttps://string-db.org/network/511145.b3481Transcriptional repressor, Ni-binding; Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel; Belongs to the transcriptio [...]
rhsB protein networkhttps://string-db.org/network/511145.b3482Rhs protein with DUF4329 family putative toxin domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family.
yhhH protein networkhttps://string-db.org/network/511145.b3483Putative NTF2 fold immunity protein for polymorphic toxin RhsB.
yhhI protein networkhttps://string-db.org/network/511145.b3484H repeat-associated putative transposase YhhI; Pseudogene fragment; Belongs to the transposase 11 family.
yhhJ protein networkhttps://string-db.org/network/511145.b3485Putative transporter.
rbbA protein networkhttps://string-db.org/network/511145.b3486Ribosome-associated ATPase: ATP-binding protein/ATP-binding membrane protein; Exhibits an intrinsic ATPase activity that is stimulated by both 70S ribosomes and 30S ribosomal subunits. Could be i [...]
yhiI protein networkhttps://string-db.org/network/511145.b3487Putative membrane fusion protein (MFP) of efflux pump; Putative membrane protein.
yhiJ protein networkhttps://string-db.org/network/511145.b3488DUF4049 family protein.
yhiM protein networkhttps://string-db.org/network/511145.b3491Inner membrane protein YhiM; Pseudogene, DUF4049 family protein.
yhiN protein networkhttps://string-db.org/network/511145.b3492Putative oxidoreductase; To H.influenzae HI_0933.
pitA protein networkhttps://string-db.org/network/511145.b3493Phosphate transporter, low-affinity; Low-affinity inorganic phosphate transport. Can also transport arsenate; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamil [...]
uspB protein networkhttps://string-db.org/network/511145.b3494Protein involved in response to stress and xenobiotic metabolic process.
uspA protein networkhttps://string-db.org/network/511145.b3495Universal stress global response regulator; Required for resistance to DNA-damaging agents; Belongs to the universal stress protein A family.
dtpB protein networkhttps://string-db.org/network/511145.b3496Dipeptide and tripeptide permease B; Proton-dependent permease that transports di- and tripeptides. Has a clear preference for dipeptides and tripeptides composed of L-amino acids, and discrimina [...]
rsmJ protein networkhttps://string-db.org/network/511145.b349716S rRNA m(2)G1516 methyltransferase, SAM-dependent; Specifically methylates the guanosine in position 1516 of 16S rRNA; Belongs to the methyltransferase superfamily. RsmJ family.
prlC protein networkhttps://string-db.org/network/511145.b3498Oligopeptidase A; May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4).
rlmJ protein networkhttps://string-db.org/network/511145.b349923S rRNA m(6)A2030 methyltransferase, SAM-dependent; Specifically methylates the adenine in position 2030 of 23S rRNA. Nascent 23S rRNA seems to be the natural substrate. Appears to be not necess [...]
gor protein networkhttps://string-db.org/network/511145.b3500Glutathione oxidoreductase; Maintains high levels of reduced glutathione in the cytosol; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
arsR protein networkhttps://string-db.org/network/511145.b3501Arsenical resistance operon transcriptional repressor; Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive [...]
arsB protein networkhttps://string-db.org/network/511145.b3502Arsenite/antimonite transporter; Involved in arsenical resistance. Thought to form the channel of an arsenite pump (By similarity); Belongs to the ArsB family.
arsC protein networkhttps://string-db.org/network/511145.b3503Arsenate reductase; Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsena [...]
insH1-11 protein networkhttps://string-db.org/network/511145.b3505Pseudogene.
slp protein networkhttps://string-db.org/network/511145.b3506Outer membrane lipoprotein; The induction of Slp may help to stabilize the outer membrane during carbon starvation and stationary phase.
dctR protein networkhttps://string-db.org/network/511145.b3507Putative LuxR family repressor for dicarboxylate transport; May act as a transcriptional regulator of dctA.
yhiD protein networkhttps://string-db.org/network/511145.b3508Putative Mg(2+) transport ATPase, inner membrane protein; Could be involved in magnesium uptake.
hdeB protein networkhttps://string-db.org/network/511145.b3509Acid-resistance protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like [...]
hdeA protein networkhttps://string-db.org/network/511145.b3510Stress response protein acid-resistance protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at pH below 3 by suppressing non- specifically the aggregatio [...]
hdeD protein networkhttps://string-db.org/network/511145.b3511Acid-resistance membrane protein.
gadE protein networkhttps://string-db.org/network/511145.b3512Gad regulon transcriptional activator; Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or g [...]
mdtE protein networkhttps://string-db.org/network/511145.b3513Anaerobic multidrug efflux transporter, ArcA-regulated; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, eth [...]
mdtF protein networkhttps://string-db.org/network/511145.b3514Anaerobic multidrug efflux transporter, ArcA-regulated; Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, eth [...]
gadW protein networkhttps://string-db.org/network/511145.b3515Transcriptional activator of gadA and gadBC; Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via t [...]
gadX protein networkhttps://string-db.org/network/511145.b3516Acid resistance regulon transcriptional activator; Positively regulates the expression of about fifteen genes involved in acid resistance such as gadA, gadB and gadC. Depending on the conditions [...]
gadA protein networkhttps://string-db.org/network/511145.b3517Glutamate decarboxylase A, PLP-dependent; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral int [...]
yhjA protein networkhttps://string-db.org/network/511145.b3518Protein involved in cytochrome complex assembly.
treF protein networkhttps://string-db.org/network/511145.b3519Cytoplasmic trehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was [...]
yhjB protein networkhttps://string-db.org/network/511145.b3520Putative DNA-binding transcriptional response regulator; Putative regulator; Protein involved in transcription activator activity and transcription.
yhjC protein networkhttps://string-db.org/network/511145.b3521Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yhjD protein networkhttps://string-db.org/network/511145.b3522Inner membrane putative BrbK family alternate lipid exporter.
yhjE protein networkhttps://string-db.org/network/511145.b3523Putative MFS transporter; Putative transport protein.
yhjG protein networkhttps://string-db.org/network/511145.b3524Putative inner membrane-anchored periplasmic AsmA family protein.
yhjH protein networkhttps://string-db.org/network/511145.b3525cyclic-di-GMP phosphodiesterase, FlhDC-regulated; Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP). Part of a sig [...]
kdgK protein networkhttps://string-db.org/network/511145.b35262-dehydro-3-deoxygluconokinase; Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Belongs to the carbohydrate kinase PfkB family.
yhjJ protein networkhttps://string-db.org/network/511145.b3527Putative periplasmic M16 family chaperone; Belongs to the peptidase M16 family.
dctA protein networkhttps://string-db.org/network/511145.b3528C4-dicarboxylic acid, orotate and citrate transporter; Responsible for the aerobic transport of the dicarboxylates fumarate, L- and D-malate and to a lesser extent succinate, from the periplasm a [...]
yhjK protein networkhttps://string-db.org/network/511145.b3529cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG.
bcsC protein networkhttps://string-db.org/network/511145.b3530Cellulose synthase subunit; Required for maximal bacterial cellulose synthesis.
bcsZ protein networkhttps://string-db.org/network/511145.b3531endo-1,4-D-glucanase; Hydrolyzes carboxymethylcellulose.
bcsB protein networkhttps://string-db.org/network/511145.b3532Regulator of cellulose synthase, cyclic di-GMP binding; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
bcsA protein networkhttps://string-db.org/network/511145.b3533Cellulose synthase, catalytic subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mec [...]
yhjR protein networkhttps://string-db.org/network/511145.b3535Protein YhjR; Involved in cellulose production, minD superfamily (pseudogene).
bcsE protein networkhttps://string-db.org/network/511145.b3536Cellulose production protein; Binds bis-(3'-5') cyclic diguanylic acid (c-di-GMP), the ability to bind c-di-GMP is important for its function ; Belongs to the BcsE family.
bcsF protein networkhttps://string-db.org/network/511145.b3537DUF2636 family cellulose production small membrane protein.
bcsG protein networkhttps://string-db.org/network/511145.b3538DUF3260 family cellulose production inner membrane protein.
yhjV protein networkhttps://string-db.org/network/511145.b3539Putative transporter protein.
dppF protein networkhttps://string-db.org/network/511145.b3540Dipeptide/heme ABC transporter ATPas; Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC t [...]
dppD protein networkhttps://string-db.org/network/511145.b3541Dipeptide/heme ABC transporter ATPas; Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system.
dppC protein networkhttps://string-db.org/network/511145.b3542Dipeptide/heme ABC transporter permease; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Be [...]
dppB protein networkhttps://string-db.org/network/511145.b3543Dipeptide/heme ABC transporter permease; Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Be [...]
dppA protein networkhttps://string-db.org/network/511145.b3544Dipeptide/heme ABC transporter periplasmic binding protein; Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis; Bel [...]
eptB protein networkhttps://string-db.org/network/511145.b3546KDO phosphoethanolamine transferase, Ca(2+)-inducible; Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid [...]
yhjX protein networkhttps://string-db.org/network/511145.b3547Pyruvate-inducible inner membrane protein, putative transporter; Part of a nutrient-sensing regulatory network composed of the two-component regulatory systems BtsS/BtsR and YpdA/YpdB, and their [...]
yhjY protein networkhttps://string-db.org/network/511145.b3548Autotransporter beta-domain protein; Putative lipase; Protein involved in fatty acid oxidation.
tag protein networkhttps://string-db.org/network/511145.b35493-methyl-adenine DNA glycosylase I, constitutive; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions.
yiaC protein networkhttps://string-db.org/network/511145.b3550GNAT family putative N-acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins. Overexpression inhibits motility.
bisC protein networkhttps://string-db.org/network/511145.b3551Biotin sulfoxide reductase; This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin [...]
yiaD protein networkhttps://string-db.org/network/511145.b3552Multicopy suppressor of bamB; Suppresses temperature-sensitive mutations in BamB when overexpressed.
ghrB protein networkhttps://string-db.org/network/511145.b3553Glyoxylate/hydroxypyruvate reductase B; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Can also reduce 2,5-diketo-D-gluconat [...]
yiaF protein networkhttps://string-db.org/network/511145.b3554Barrier effect co-colonization resistance factor; DUF3053 family lipoprotein.
yiaG protein networkhttps://string-db.org/network/511145.b3555HTH_CROC1 family putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent.
cspA protein networkhttps://string-db.org/network/511145.b3556RNA chaperone and antiterminator, cold-inducible; Binds to and stimulates the transcription of the CCAAT- containing, cold-shock-inducible promoters of the H-NS and GyrA proteins. Binds also to t [...]
insJ protein networkhttps://string-db.org/network/511145.b3557IS150 transposase A; Belongs to the IS150/IS1296 orfA family.
insK protein networkhttps://string-db.org/network/511145.b3558IS150 transposase B; Involved in the transposition of the insertion sequence IS150; Belongs to the transposase IS3/IS150/IS904 family.
glyS protein networkhttps://string-db.org/network/511145.b3559Glycine tRNA synthetase, beta subunit; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-II aminoacyl-tRNA synthetase family.
glyQ protein networkhttps://string-db.org/network/511145.b3560Glycine tRNA synthetase, alpha subunit; Protein involved in tRNA aminoacylation for protein translation; Belongs to the class-II aminoacyl-tRNA synthetase family.
wecH protein networkhttps://string-db.org/network/511145.b3561O-acetyltransferase for enterobacterial common antigen (ECA); Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units. Cataly [...]
yiaA protein networkhttps://string-db.org/network/511145.b3562YiaAB family inner membrane protein, tandem domains.
yiaB protein networkhttps://string-db.org/network/511145.b3563YiaAB family inner membrane protein.
xylB protein networkhttps://string-db.org/network/511145.b3564Xylulokinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate. Also catalyzes the phosphorylation of 1- deoxy-D-xylulose to 1-deoxy-D-xylulose 5-phosphate, with lower effic [...]
xylA protein networkhttps://string-db.org/network/511145.b3565D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family.
xylF protein networkhttps://string-db.org/network/511145.b3566D-xylose transporter subunit; Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose.
xylG protein networkhttps://string-db.org/network/511145.b3567D-xylose ABC transporter dual domain ATPase; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system (Probable). The XylFGH s [...]
xylH protein networkhttps://string-db.org/network/511145.b3568D-xylose ABC transporter permease; Part of the binding-protein-dependent transport system for D- xylose. Probably responsible for the translocation of the substrate across the membrane; Belongs t [...]
xylR protein networkhttps://string-db.org/network/511145.b3569Xylose divergent operon transcriptional activator; Regulatory protein for the xylBAFGHR operon.
bax protein networkhttps://string-db.org/network/511145.b3570Putative ATP-binding protein.
malS protein networkhttps://string-db.org/network/511145.b3571Alpha-amylase; Since only maltooligosaccharides up to a chain length of 6 glucose units are actively transported through the cytoplasmic membrane via the membrane-bound complex of three proteins, [...]
avtA protein networkhttps://string-db.org/network/511145.b3572Valine-pyruvate aminotransferase; Involved in the biosynthesis of alanine. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
ysaA protein networkhttps://string-db.org/network/511145.b3573Putative hydrogenase, 4Fe-4S ferredoxin-type component.
yiaJ protein networkhttps://string-db.org/network/511145.b3574Transcriptional repressor for the yiaKLMNO-lyxK-sgbHUE operon; Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L- gulonate [...]
yiaK protein networkhttps://string-db.org/network/511145.b35752,3-diketo-L-gulonate reductase, NADH-dependent; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
yiaL protein networkhttps://string-db.org/network/511145.b3576DUF386 family protein; Putative lipase; Belongs to the TabA/YhcH/YiaL family.
yiaM protein networkhttps://string-db.org/network/511145.b35772,3-diketo-L-gulonate TRAP transporter small permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate.
yiaN protein networkhttps://string-db.org/network/511145.b35782,3-diketo-L-gulonate TRAP transporter large permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate.
yiaO protein networkhttps://string-db.org/network/511145.b35792,3-diketo-L-gulonate-binding periplasmic protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. This protein [...]
lyxK protein networkhttps://string-db.org/network/511145.b3580L-xylulose kinase; Catalyzes the phosphorylation of L-xylulose and 3-keto-L- gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo- [...]
sgbH protein networkhttps://string-db.org/network/511145.b35813-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3-diketo-L- gulonate.
sgbU protein networkhttps://string-db.org/network/511145.b3582Putative L-xylulose 5-phosphate 3-epimerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulon [...]
sgbE protein networkhttps://string-db.org/network/511145.b3583L-ribulose-5-phosphate 4-epimerase; Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleava [...]
yiaT protein networkhttps://string-db.org/network/511145.b3584Putative outer membrane protein YiaT; Pseudogene, internal sequence remnant.
yiaU protein networkhttps://string-db.org/network/511145.b3585Putative transcriptional regulator LYSR-type; Protein involved in transcription activator activity, transcription repressor activity and transcription; Belongs to the LysR transcriptional regulat [...]
yiaV protein networkhttps://string-db.org/network/511145.b3586Signal-anchored membrane fusion protein (MFP) component of efflux pump; Putative membrane protein.
yiaW protein networkhttps://string-db.org/network/511145.b3587DUF3302 family inner membrane protein.
aldB protein networkhttps://string-db.org/network/511145.b3588Aldehyde dehydrogenase B; Catalyzes the NADP-dependent oxidation of diverse aldehydes such as chloroacetaldehyde, acetaldehyde, propionaldehyde, benzaldehyde, mafosfamide, 4-hydroperoxycyclophosp [...]
yiaY protein networkhttps://string-db.org/network/511145.b3589L-threonine dehydrogenase; Putative oxidoreductase.
selB protein networkhttps://string-db.org/network/511145.b3590selenocysteinyl-tRNA-specific translation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocystein [...]
selA protein networkhttps://string-db.org/network/511145.b3591Selenocysteine synthase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule; Belongs to the Sel [...]
yibF protein networkhttps://string-db.org/network/511145.b3592Glutathione S-transferase homolog; Glutathione (GSH) transferase homolog, that might be involved in selenium metabolism.
rhsA protein networkhttps://string-db.org/network/511145.b3593Rhs protein with putative toxin 55 domain; Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell; Belongs to the RHS family.
yibA protein networkhttps://string-db.org/network/511145.b3594Putative immunity protein for polymorphic toxin RhsA; HEAT-domain protein; lethality reduction protein.
yibG protein networkhttps://string-db.org/network/511145.b3596Uncharacterized protein YibG; Rhs-family protein.
yibH protein networkhttps://string-db.org/network/511145.b3597Inner membrane protein YibH; Pseudogene, H repeat-associated protein.
yibI protein networkhttps://string-db.org/network/511145.b3598DUF3302 family inner membrane protein; To E.coli YiaW.
mtlA protein networkhttps://string-db.org/network/511145.b3599Mannitol-specific PTS enzyme: IIA, IIB and IIC components; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes t [...]
mtlD protein networkhttps://string-db.org/network/511145.b3600Mannitol-1-phosphate dehydrogenase, NAD-dependent; Mannitol-1-phosphate dehydrogenase; Protein involved in carbohydrate catabolic process.
mtlR protein networkhttps://string-db.org/network/511145.b3601Mannitol operon repressor; Involved in the repression of the expression of the mannitol mtlADR operon. Does not bind the operator/promoter regulatory region of this operon. Therefore, seems to be [...]
yibL protein networkhttps://string-db.org/network/511145.b3602Ribosome-associated DUF2810 family protein.
lldP protein networkhttps://string-db.org/network/511145.b3603L-lactate permease; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force.
lldR protein networkhttps://string-db.org/network/511145.b3604Dual role activator/repressor for lldPRD operon; May be a regulatory protein for the LCT genes.
lldD protein networkhttps://string-db.org/network/511145.b3605L-lactate dehydrogenase, FMN-linked; Catalyzes the conversion of L-lactate to pyruvate. Seems to be a primary dehydrogenase in the respiratory chain. To a lesser extent, can also oxidize DL-alpha [...]
trmL protein networkhttps://string-db.org/network/511145.b3606tRNA Leu mC34,mU34 2'-O-methyltransferase, SAM-dependent; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catal [...]
cysE protein networkhttps://string-db.org/network/511145.b3607Serine acetyltransferase; Protein involved in cysteine biosynthetic process; Belongs to the transferase hexapeptide repeat family.
gpsA protein networkhttps://string-db.org/network/511145.b3608Glycerol-3-phosphate dehydrogenase (NAD+); Protein involved in glycerol metabolic process and phosphorus metabolic process; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
secB protein networkhttps://string-db.org/network/511145.b3609Protein export chaperone; One of the proteins required for the normal export of some preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor protein [...]
grxC protein networkhttps://string-db.org/network/511145.b3610Glutaredoxin 3; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also [...]
yibN protein networkhttps://string-db.org/network/511145.b3611Putative rhodanese-related sulfurtransferase.
gpmM protein networkhttps://string-db.org/network/511145.b3612Phosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate (2-PGA) and 3-phosphoglycerate (3-PGA).
envC protein networkhttps://string-db.org/network/511145.b3613Activator of AmiB,C murein hydrolases, septal ring factor; Activator of the cell wall hydrolases AmiA and AmiB. Required for septal murein cleavage and daughter cell separation during cell divisi [...]
yibQ protein networkhttps://string-db.org/network/511145.b3614Putative polysaccharide deacetylase; To H.influenzae HI_0755.
waaH protein networkhttps://string-db.org/network/511145.b3615LPS(HepIII)-glucuronic acid glycosyltransferase; Putative regulator; Belongs to the glycosyltransferase 2 family.
tdh protein networkhttps://string-db.org/network/511145.b3616L-threonine 3-dehydrogenase, NAD(P)-binding; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate. To a lesser extent, also catalyzes the oxidation of D-allo-threoni [...]
kbl protein networkhttps://string-db.org/network/511145.b3617Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
yibB protein networkhttps://string-db.org/network/511145.b3618YibB family protein, function unknown; Involved in lipopolysaccharide biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide biosynthetic process [...]
hldD protein networkhttps://string-db.org/network/511145.b3619ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at [...]
waaF protein networkhttps://string-db.org/network/511145.b3620ADP-heptose--lps heptosyltransferase II; lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosynthetic [...]
waaC protein networkhttps://string-db.org/network/511145.b3621ADP-heptose:LPS heptosyl transferase I; Heptose transfer to the lipopolysaccharide core. It transfers the innermost heptose to [4'-P](3-deoxy-D-manno-octulosonic acid)2-IVA; Belongs to the glycos [...]
waaL protein networkhttps://string-db.org/network/511145.b3622O-antigen ligase; Adds the O-antigen on the glucose group of LPS.
waaU protein networkhttps://string-db.org/network/511145.b3623Lipopolysaccharide core biosynthesis; Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS.
waaZ protein networkhttps://string-db.org/network/511145.b3624Lipopolysaccharide KdoIII transferase; Lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosynthetic pr [...]
waaY protein networkhttps://string-db.org/network/511145.b3625Lipopolysaccharide core biosynthesis protein; Catalyzes the phosphorylation of heptose(II) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. RfaY/WaaY fami [...]
waaR protein networkhttps://string-db.org/network/511145.b3626Lipopolysaccharide 1,2-glucosyltransferase; Adds the glucose(II) group on the galactose(I) group of LPS.
waaO protein networkhttps://string-db.org/network/511145.b3627UDP-D-galactose:(glucosyl)lipopolysaccharide- alpha-1,3-D-galactosyltransferase; Protein involved in cell surface antigen activity, host-interacting; Belongs to the glycosyltransferase 8 family.
waaB protein networkhttps://string-db.org/network/511145.b3628Lipopolysaccharide 1,6-galactosyltransferase; Adds a galactose goup to a glucose group of LPS; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
waaS protein networkhttps://string-db.org/network/511145.b3629Lipopolysaccharide rhamnose:KdoIII transferase; Lipopolysaccharide core biosynthesis; Protein involved in cell surface antigen activity, host-interacting and lipopolysaccharide core region biosyn [...]
waaP protein networkhttps://string-db.org/network/511145.b3630Kinase that phosphorylates core heptose of lipopolysaccharide; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core.
waaG protein networkhttps://string-db.org/network/511145.b3631UDP-glucose:(heptosyl)lipopolysaccharide alpha-1,3-glucosyltransferase; Involved in the addition of the first glucose residue to the lipopolysaccharide core; Belongs to the glycosyltransferase gr [...]
waaQ protein networkhttps://string-db.org/network/511145.b3632Lipopolysaccharide core biosynthesis protein; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core (By simi [...]
waaA protein networkhttps://string-db.org/network/511145.b36333-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from C [...]
coaD protein networkhttps://string-db.org/network/511145.b3634Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. CoA is not a substrate for [...]
mutM protein networkhttps://string-db.org/network/511145.b3635Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recogn [...]
rpmG protein networkhttps://string-db.org/network/511145.b363650S ribosomal subunit protein L33; Protein involved in structural constituent of ribosome and translation.
rpmB protein networkhttps://string-db.org/network/511145.b363750S ribosomal subunit protein L28; Protein involved in structural constituent of ribosome and translation.
yicR protein networkhttps://string-db.org/network/511145.b3638UPF0758 family protein; DNA repair protein; Protein involved in DNA-dependent DNA replication and DNA repair; Belongs to the UPF0758 family. YicR subfamily.
dfp protein networkhttps://string-db.org/network/511145.b3639Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4 [...]
dut protein networkhttps://string-db.org/network/511145.b3640Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration o [...]
slmA protein networkhttps://string-db.org/network/511145.b3641Nucleoid occlusion factor, anti-FtsZ division inhibitor; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associ [...]
pyrE protein networkhttps://string-db.org/network/511145.b3642Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); B [...]
yicC protein networkhttps://string-db.org/network/511145.b3644UPF0701 protein YicC; Ribonuclease PH (defective);enzyme; Degradation of RNA; RNase PH; Protein involved in RNA catabolic process.
dinD protein networkhttps://string-db.org/network/511145.b3645Protein involved in DNA repair.
yicG protein networkhttps://string-db.org/network/511145.b3646UPF0126 family inner membrane protein.
ligB protein networkhttps://string-db.org/network/511145.b3647DNA ligase, NAD(+)-dependent; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy sour [...]
gmk protein networkhttps://string-db.org/network/511145.b3648Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. Belongs to the guanylate kinase family.
rpoZ protein networkhttps://string-db.org/network/511145.b3649RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
spoT protein networkhttps://string-db.org/network/511145.b3650Bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent respo [...]
trmH protein networkhttps://string-db.org/network/511145.b3651tRNA mG18-2'-O-methyltransferase, SAM-dependent; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA. Type II methylase, which methylates only a subset of tRNA species; Belongs to [...]
recG protein networkhttps://string-db.org/network/511145.b3652ATP-dependent DNA helicase; Plays a critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwin [...]
gltS protein networkhttps://string-db.org/network/511145.b3653Glutamate transporter; Catalyzes the sodium-dependent, binding-protein-independent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
xanP protein networkhttps://string-db.org/network/511145.b3654Xanthine permease; Specific, proton motive force-dependent high-affinity transporter for xanthine; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) [...]
yicH protein networkhttps://string-db.org/network/511145.b3655Putative inner membrane-anchored periplasmic AsmA family protein; Belongs to the AsmA family.
yicI protein networkhttps://string-db.org/network/511145.b3656Putative alpha-glucosidase; Can catalyze the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose and tre [...]
yicJ protein networkhttps://string-db.org/network/511145.b3657Putative permease.
setC protein networkhttps://string-db.org/network/511145.b3659Sugar efflux transporter C; Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs; Belongs to the major facilitator superfamily. Se [...]
yicL protein networkhttps://string-db.org/network/511145.b3660EamA family inner membrane putative transporter; Putative permease transporter.
nlpA protein networkhttps://string-db.org/network/511145.b3661Cytoplasmic membrane lipoprotein-28; Lipoprotein-28.
nepI protein networkhttps://string-db.org/network/511145.b3662Putative transporter; Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine.
yicN protein networkhttps://string-db.org/network/511145.b3663DUF1198 family protein.
adeQ protein networkhttps://string-db.org/network/511145.b3664Adenine permease, high affinity; High-affinity transporter for adenine.
adeD protein networkhttps://string-db.org/network/511145.b3665Cryptic adenine deaminase; Protein involved in metabolic process; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
uhpT protein networkhttps://string-db.org/network/511145.b3666Hexose phosphate transporter; Mediates the exchange of external hexose 6-phosphate and internal inorganic phosphate. Can transport glucose-6-phosphate, fructose-6-phosphate and mannose-6-phosphat [...]
uhpC protein networkhttps://string-db.org/network/511145.b3667Membrane protein regulates uhpT expression; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC senses external glucose-6-phosphate an [...]
uhpB protein networkhttps://string-db.org/network/511145.b3668Sensory histidine kinase in two-component regulatory sytem with UhpA; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpB functions as [...]
uhpA protein networkhttps://string-db.org/network/511145.b3669Response regulator in two-component regulatory system wtih UhpB; Part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. Activates the transcri [...]
ilvN protein networkhttps://string-db.org/network/511145.b3670Acetolactate synthase I, valine sensitive, small subunit.
ilvB protein networkhttps://string-db.org/network/511145.b3671Acetolactate synthase I,valine-sensitive, large subunit.
ivbL protein networkhttps://string-db.org/network/511145.b3672ilvB operon leader peptide; This protein is involved in control of the biosynthesis of isoleucine, leucine, and valine.
emrD protein networkhttps://string-db.org/network/511145.b3673Multidrug efflux system protein; Multidrug resistance pump that participates in a low energy shock adaptive response; Belongs to the major facilitator superfamily.
yidF protein networkhttps://string-db.org/network/511145.b3674Putative Cys-type oxidative YidJ-maturating enzyme; Putative transcriptional regulator.
yidG protein networkhttps://string-db.org/network/511145.b3675Inner membrane protein.
yidH protein networkhttps://string-db.org/network/511145.b3676DUF202 family inner membrane protein.
yidI protein networkhttps://string-db.org/network/511145.b3677Inner membrane protein.
yidJ protein networkhttps://string-db.org/network/511145.b3678Sulfatase/phosphatase superfamily protein; Putative sulfatase; Protein involved in sulfur metabolic process; Belongs to the sulfatase family.
yidK protein networkhttps://string-db.org/network/511145.b3679Putative cotransporter.
yidL protein networkhttps://string-db.org/network/511145.b3680Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
yidP protein networkhttps://string-db.org/network/511145.b3684Uncharacterized HTH-type transcriptional regulator YidP; Pseudogene, arbutin specific enzyme IIC component of PTS;enzyme; Transport of small molecules: Carbohydrates, organic acids, alcohols; PTS [...]
yidE protein networkhttps://string-db.org/network/511145.b3685Putative transport protein.
ibpB protein networkhttps://string-db.org/network/511145.b3686Heat shock chaperone; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidati [...]
ibpA protein networkhttps://string-db.org/network/511145.b3687Heat shock chaperone; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidati [...]
yidQ protein networkhttps://string-db.org/network/511145.b3688DUF1375 family outer membrane protein; To E.coli YceK.
yidR protein networkhttps://string-db.org/network/511145.b3689DUF3748 family protein.
cbrA protein networkhttps://string-db.org/network/511145.b3690Colicin M resistance protein; FAD-binding protein, putative oxidoreductase; Belongs to the CbrA family.
dgoT protein networkhttps://string-db.org/network/511145.b3691D-galactonate transporter; Intake of galactonate into the cell; Belongs to the major facilitator superfamily. Phthalate permease family.
dgoK protein networkhttps://string-db.org/network/511145.b36932-oxo-3-deoxygalactonate kinase; Protein involved in carbohydrate catabolic process; Belongs to the DgoK family.
yidX protein networkhttps://string-db.org/network/511145.b3696Putative replicase EC 2.7.-.
yidA protein networkhttps://string-db.org/network/511145.b3697Sugar phosphate phosphatase; Catalyzes the dephosphorylation of different sugar phosphates including erythrose-4-phosphate (Ery4P), ribose-5-phosphate (Ribu5P), fructose-1-phosphate (Fru1P), fruc [...]
yidB protein networkhttps://string-db.org/network/511145.b3698DUF937 family protein.
gyrB protein networkhttps://string-db.org/network/511145.b3699DNA gyrase, subunit B; DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrate [...]
recF protein networkhttps://string-db.org/network/511145.b3700Gap repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It al [...]
dnaN protein networkhttps://string-db.org/network/511145.b3701DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loadi [...]
dnaA protein networkhttps://string-db.org/network/511145.b3702Chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator; Plays a key role in the initiation and regulation of chromosomal replication. Binds in an ATP-dependent [...]
rpmH protein networkhttps://string-db.org/network/511145.b370350S ribosomal subunit protein L34; Protein involved in structural constituent of ribosome and translation; Belongs to the bacterial ribosomal protein bL34 family.
rnpA protein networkhttps://string-db.org/network/511145.b3704Protein C5 component of RNase P; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. [...]
yidC protein networkhttps://string-db.org/network/511145.b3705Membrane protein insertase; Inner membrane protein required for the insertion and/or proper folding and/or complex formation of integral inner membrane proteins. Involved in integration of membra [...]
mnmE protein networkhttps://string-db.org/network/511145.b3706tRNA U34 5-methylaminomethyl-2-thiouridine modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the w [...]
tnaC protein networkhttps://string-db.org/network/511145.b3707Tryptophanase leader peptide; Required for tryptophan-regulated expression of the tna operon. In the presence of free L-Trp release of this nascent peptide by release factor 2 is inhibited and th [...]
tnaA protein networkhttps://string-db.org/network/511145.b3708tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Tryptophanase; Protein involved in cellular amino acid catabolic process; Belongs to the beta-eliminating lyase family.
tnaB protein networkhttps://string-db.org/network/511145.b3709Tryptophan transporter of low affinity; Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically.
mdtL protein networkhttps://string-db.org/network/511145.b3710Multidrug efflux system protein; Confers resistance to chloramphenicol. Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
yidZ protein networkhttps://string-db.org/network/511145.b3711Putative DNA-binding transcriptional regulator; Involved in anaerobic NO protection.
yieE protein networkhttps://string-db.org/network/511145.b3712Phosphopantetheinyl transferase superfamily protein.
chrR protein networkhttps://string-db.org/network/511145.b3713Chromate reductase, Class I, flavoprotein; Catalyzes the reduction of quinones. Acts by simultaneous two-electron transfer, avoiding formation of highly reactive semiquinone intermediates and pro [...]
adeP protein networkhttps://string-db.org/network/511145.b3714Adenine permease, high affinity; High-affinity transporter for adenine. Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily.
yieH protein networkhttps://string-db.org/network/511145.b3715Phosphoenolpyruvate and 6-phosphogluconate phosphatase; Catalyzes strongly the dephosphorylation of 6- phosphogluconate (6P-Glu) and slightly the dephosphorylation of dihydroxyacetone phosphate ( [...]
cbrB protein networkhttps://string-db.org/network/511145.b3716PRK09823 family inner membrane protein, creBC regulon.
cbrC protein networkhttps://string-db.org/network/511145.b3717UPF0167 family protein; Belongs to the UPF0167 family.
yieK protein networkhttps://string-db.org/network/511145.b3718Putative 6-phosphogluconolactonase; Pyrimidine-specific nucleoside hydrolase; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
yieL protein networkhttps://string-db.org/network/511145.b3719Putative xylanase; Protein involved in carbohydrate catabolic process.
bglH protein networkhttps://string-db.org/network/511145.b3720Carbohydrate-specific outer membrane porin, cryptic; Part of a cryptic operon that is poorly expressed in vivo. May be an ancestral sugar porin with a broad carbohydrate specificity; it binds aro [...]
bglB protein networkhttps://string-db.org/network/511145.b3721Cryptic phospho-beta-glucosidase B; Catalyzes the hydrolysis of phosphorylated beta-glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic be [...]
bglF protein networkhttps://string-db.org/network/511145.b3722Fused beta-glucoside-specific PTS enzymes: IIA component/IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -t [...]
bglG protein networkhttps://string-db.org/network/511145.b3723Transcriptional antiterminator of the bgl operon; Mediates the positive regulation of the beta-glucoside (bgl) operon by functioning as a transcriptional antiterminator. This is an RNA-binding pr [...]
phoU protein networkhttps://string-db.org/network/511145.b3724Negative regulator of PhoR/PhoB two-component regulator; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. Encoded together with proteins of the phosphate-spec [...]
pstB protein networkhttps://string-db.org/network/511145.b3725Phosphate ABC transporter ATPase; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter [...]
pstA protein networkhttps://string-db.org/network/511145.b3726Phosphate ABC transporter permease; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs [...]
pstC protein networkhttps://string-db.org/network/511145.b3727Phosphate ABC transporter permease; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs [...]
pstS protein networkhttps://string-db.org/network/511145.b3728Phosphate ABC transporter periplasmic binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.
glmS protein networkhttps://string-db.org/network/511145.b3729L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
glmU protein networkhttps://string-db.org/network/511145.b3730Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acet [...]
atpC protein networkhttps://string-db.org/network/511145.b3731F1 sector of membrane-bound ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the ATPase epsilon chain family.
atpD protein networkhttps://string-db.org/network/511145.b3732F1 sector of membrane-bound ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subuni [...]
atpG protein networkhttps://string-db.org/network/511145.b3733F1 sector of membrane-bound ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating [...]
atpA protein networkhttps://string-db.org/network/511145.b3734F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
atpH protein networkhttps://string-db.org/network/511145.b3735F1 sector of membrane-bound ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domai [...]
atpF protein networkhttps://string-db.org/network/511145.b3736F0 sector of membrane-bound ATP synthase, subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, [...]
atpE protein networkhttps://string-db.org/network/511145.b3737F0 sector of membrane-bound ATP synthase, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, [...]
atpB protein networkhttps://string-db.org/network/511145.b3738F0 sector of membrane-bound ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
atpI protein networkhttps://string-db.org/network/511145.b3739ATP synthase, membrane-bound accessory factor; A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex; Belongs to the bacterial AtpI fam [...]
rsmG protein networkhttps://string-db.org/network/511145.b374016S rRNA m(7)G527 methyltransferase, SAM-dependent; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. Requires the intact 30S subunit for methylation; Belongs to the [...]
mnmG protein networkhttps://string-db.org/network/511145.b37415-methylaminomethyl-2-thiouridine modification at tRNA U34; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, [...]
mioC protein networkhttps://string-db.org/network/511145.b3742FMN-binding protein MioC; Probable electron transporter required for biotin synthase activity.
asnC protein networkhttps://string-db.org/network/511145.b3743Transcriptional activator of asnA; Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post- transcriptional level.
asnA protein networkhttps://string-db.org/network/511145.b3744Asparagine synthetase A; May amidate Asp of the extracellular death factor precursor Asn-Asn-Trp-Asp-Asn to generate Asn-Asn-Trp-Asn-Asn.
viaA protein networkhttps://string-db.org/network/511145.b3745Stimulator of RavA ATPase activity; von Willebrand factor domain protein.
ravA protein networkhttps://string-db.org/network/511145.b3746Hexameric AAA+ MoxR family ATPase, putative molecular chaperone; Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone.
kup protein networkhttps://string-db.org/network/511145.b3747Potassium transporter; Responsible for the low-affinity transport of potassium into the cell, with the probable concomitant uptake of protons (symport system). Can also transport cesium; Belongs [...]
rbsD protein networkhttps://string-db.org/network/511145.b3748D-ribose pyranase; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. It also catalyzes the conversion between beta- allofuranose and beta-allopyranose; Belongs to the [...]
rbsA protein networkhttps://string-db.org/network/511145.b3749D-ribose ABC transporter ATPase; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter supe [...]
rbsC protein networkhttps://string-db.org/network/511145.b3750D-ribose ABC transporter permease; Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane.
rbsB protein networkhttps://string-db.org/network/511145.b3751D-ribose ABC transporter periplasmic binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose. Also serves as the primary chemoreceptor for chemotaxis; [...]
rbsK protein networkhttps://string-db.org/network/511145.b3752Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histi [...]
rbsR protein networkhttps://string-db.org/network/511145.b3753Transcriptional repressor of ribose metabolism; Transcriptional repressor for the ribose rbsDACBK operon. RbsR binds to a region of perfect dyad symmetry spanning the rbs operon transcriptional s [...]
hsrA protein networkhttps://string-db.org/network/511145.b3754Putative multidrug or homocysteine efflux system; Putative transport protein (MFS family); high copy suppressor of RspA: relieves RspA-mediated reduction of sigma(S) levels; overexpression also r [...]
yieP protein networkhttps://string-db.org/network/511145.b3755Putative transcriptional regulator.
yifE protein networkhttps://string-db.org/network/511145.b3764UPF0438 family protein; Protein involved in regulation of transcription, DNA-dependent; Belongs to the UPF0438 family.
yifB protein networkhttps://string-db.org/network/511145.b3765Magnesium chelatase family protein and putative transcriptional regulator; Putative 2-component regulator; Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.
ilvL protein networkhttps://string-db.org/network/511145.b3766ilvGEDA operon leader peptide.
ilvM protein networkhttps://string-db.org/network/511145.b3769Pseudogene, acetolactate synthase 2 large subunit, valine-insensitive; acetolactate synthase II, large subunit, cryptic, interrupted.
ilvE protein networkhttps://string-db.org/network/511145.b3770Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine.
ilvD protein networkhttps://string-db.org/network/511145.b3771Dihydroxyacid dehydratase.
ilvA protein networkhttps://string-db.org/network/511145.b3772L-threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonin [...]
ilvY protein networkhttps://string-db.org/network/511145.b3773Transcriptional activator of ilvC; This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own [...]
ilvC protein networkhttps://string-db.org/network/511145.b3774Ketol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolacta [...]
ppiC protein networkhttps://string-db.org/network/511145.b3775Peptidyl-prolyl cis-trans isomerase C (rotamase C); PPIases accelerate the folding of proteins. It prefers amino acid residues with hydrophobic side chains like leucine and phenylalanine in the P [...]
rep protein networkhttps://string-db.org/network/511145.b3778ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded [...]
gpp protein networkhttps://string-db.org/network/511145.b3779Guanosine pentaphosphatase/exopolyphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp control [...]
rhlB protein networkhttps://string-db.org/network/511145.b3780ATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB su [...]
trxA protein networkhttps://string-db.org/network/511145.b3781Thioredoxin 1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
rho protein networkhttps://string-db.org/network/511145.b3783Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and releas [...]
wecA protein networkhttps://string-db.org/network/511145.b3784UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yie [...]
wzzE protein networkhttps://string-db.org/network/511145.b3785Entobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA). Required for the assembly of [...]
wecB protein networkhttps://string-db.org/network/511145.b3786UDP-N-acetyl glucosamine-2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNA [...]
wecC protein networkhttps://string-db.org/network/511145.b3787UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic [...]
rffG protein networkhttps://string-db.org/network/511145.b3788dTDP-glucose 4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction; Belongs [...]
rffH protein networkhttps://string-db.org/network/511145.b3789Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymid [...]
wecD protein networkhttps://string-db.org/network/511145.b3790TDP-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacteria [...]
wecE protein networkhttps://string-db.org/network/511145.b3791TDP-4-oxo-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate.
wzxE protein networkhttps://string-db.org/network/511145.b3792O-antigen translocase; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ente [...]
wzyE protein networkhttps://string-db.org/network/511145.b3793Putative ECA polysaccharide chain elongation protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units. Required for the assembly of the [...]
wecG protein networkhttps://string-db.org/network/511145.b3794UDP-N-acetyl-D-mannosaminuronic acid transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA [...]
yifK protein networkhttps://string-db.org/network/511145.b3795Putative APC family amino acid transporter; Probable amino-acid or metabolite transport protein; Belongs to the amino acid-polyamine-organocation (APC) superfamily.
aslB protein networkhttps://string-db.org/network/511145.b3800Putative AslA-specific sulfatase-maturating enzyme; Putative arylsulfatase regulator; Protein involved in sulfur metabolic process and protein folding; Belongs to the radical SAM superfamily. Ana [...]
aslA protein networkhttps://string-db.org/network/511145.b3801Putative Ser-type periplasmic non-aryl sulfatase; No E.coli strains have been observed to have an arylsulfatase activity. A 'latent' activity has been observed by heterologous expression of a gen [...]
hemY protein networkhttps://string-db.org/network/511145.b3802Putative protoheme IX synthesis protein; Involved in a late step of protoheme IX synthesis.
hemX protein networkhttps://string-db.org/network/511145.b3803Uroporphyrinogen III methylase.
hemD protein networkhttps://string-db.org/network/511145.b3804Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. Belongs to the uroporphyrinogen-III synthase family.
hemC protein networkhttps://string-db.org/network/511145.b3805Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
cyaA protein networkhttps://string-db.org/network/511145.b3806Adenylate cyclase; Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regula [...]
cyaY protein networkhttps://string-db.org/network/511145.b3807Iron-dependent inhibitor of iron-sulfur cluster formation; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. Can bind both Fe(2+) and Fe(3+) ions. In viv [...]
dapF protein networkhttps://string-db.org/network/511145.b3809Diaminopimelate epimerase; Involved in the succinylase branch of the L-lysine biosynthesis and in the biosynthesis of the pentapeptide incorporated in the peptidoglycan moiety. Catalyzes the ster [...]
yigA protein networkhttps://string-db.org/network/511145.b3810DUF484 family protein.
xerC protein networkhttps://string-db.org/network/511145.b3811Site-specific tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA co [...]
yigB protein networkhttps://string-db.org/network/511145.b38125-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase; Catalyzes the dephosphorylation of 5-amino-6-(5-phospho-D- ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis p [...]
uvrD protein networkhttps://string-db.org/network/511145.b3813DNA-dependent ATPase I and helicase II; A helicase with DNA-dependent ATPase activity. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand. Initiates unwinding more effic [...]
corA protein networkhttps://string-db.org/network/511145.b3816Magnesium/nickel/cobalt transporter; Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake. Alternates between open and closed states. Activated by low cytoplasmic Mg(2+ [...]
yigF protein networkhttps://string-db.org/network/511145.b3817DUF2628 family putative inner membrane protein.
yigG protein networkhttps://string-db.org/network/511145.b3818PRK11371 family inner membrane protein.
rarD protein networkhttps://string-db.org/network/511145.b3819Putative chloramphenical resistance permease; Protein involved in response to drug and chloramphenicol transport.
yigI protein networkhttps://string-db.org/network/511145.b38204HBT thioesterase family protein.
pldA protein networkhttps://string-db.org/network/511145.b3821Outer membrane phospholipase A; Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Stron [...]
recQ protein networkhttps://string-db.org/network/511145.b3822ATP-dependent DNA helicase; Involved in the RecF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase; Belongs to the helicase family. RecQ s [...]
rhtC protein networkhttps://string-db.org/network/511145.b3823Threonine efflux pump; Conducts the efflux of threonine. Belongs to the Rht family.
rhtB protein networkhttps://string-db.org/network/511145.b3824Homoserine, homoserine lactone and S-methyl-methionine efflux pump; Conducts the efflux of homoserine and homoserine lactone. Belongs to the Rht family.
pldB protein networkhttps://string-db.org/network/511145.b3825Lysophospholipase L2; Protein involved in phosphorus metabolic process.
yigL protein networkhttps://string-db.org/network/511145.b3826Pyridoxal phosphate phosphatase; Catalyzes Strongly the dephosphorylation of pyridoxal- phosphate (PLP) and moderately the dephosphorylation of 2-deoxyglucose 6-phosphate (2bGLU6P) and beta-gluco [...]
yigM protein networkhttps://string-db.org/network/511145.b3827Putative inner membrane EamA-like transporter; Uptake of biotin. Acts probably by facilitated diffusion. Belongs to the drug/metabolite transporter (DMT) superfamily. 10 TMS drug/metabolite expor [...]
metR protein networkhttps://string-db.org/network/511145.b3828Methionine biosynthesis regulon transcriptional regulator; Control of the last step in methionine biosynthesis; MetR is a positive activator of the metA, metE and metH genes. MetR is also a negat [...]
metE protein networkhttps://string-db.org/network/511145.b38295-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.
ysgA protein networkhttps://string-db.org/network/511145.b3830Putative enzyme.
udp protein networkhttps://string-db.org/network/511145.b3831Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as c [...]
rmuC protein networkhttps://string-db.org/network/511145.b3832DNA recombination protein; Involved in DNA recombination.
ubiE protein networkhttps://string-db.org/network/511145.b3833Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6 [...]
ubiJ protein networkhttps://string-db.org/network/511145.b3834Aerobic ubiquinone synthesis protein, SCP2 family protein; Required for ubiquinone (coenzyme Q) biosynthesis under aerobic conditions. Binds hydrophobic ubiquinone biosynthetic intermediates via [...]
ubiB protein networkhttps://string-db.org/network/511145.b3835Regulator of octaprenylphenol hydroxylation, ubiquinone synthesis; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belon [...]
tatA protein networkhttps://string-db.org/network/511145.b3836TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their [...]
tatB protein networkhttps://string-db.org/network/511145.b3838TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their [...]
tatC protein networkhttps://string-db.org/network/511145.b3839TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their [...]
rfaH protein networkhttps://string-db.org/network/511145.b3842Transcription antitermination protein; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-co [...]
ubiD protein networkhttps://string-db.org/network/511145.b38433-octaprenyl-4-hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis; Belongs to t [...]
fre protein networkhttps://string-db.org/network/511145.b3844NAD(P)H-flavin reductase; Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides; Belongs to the Fre/LuxG FAD/NAD(P) flavoprotein oxidoreductase family.
fadA protein networkhttps://string-db.org/network/511145.b38453-ketoacyl-CoA thiolase (thiolase I); Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in [...]
fadB protein networkhttps://string-db.org/network/511145.b3846Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation [...]
pepQ protein networkhttps://string-db.org/network/511145.b3847Proline dipeptidase; Splits dipeptides with a prolyl residue in the C-terminal position and a polar or nonpolar amino acid at the N-terminal position. With much lower efficiency, also catalyzes t [...]
yigZ protein networkhttps://string-db.org/network/511145.b3848UPF0029 family protein; Protein involved in translation; Belongs to the IMPACT family.
trkH protein networkhttps://string-db.org/network/511145.b3849Potassium transporter; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA. Requires TrkE (sapD) for transport activity, 20% more uptake is seen with [...]
hemG protein networkhttps://string-db.org/network/511145.b3850Protoporphyrin oxidase, flavoprotein; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as electron acceptor.
mobB protein networkhttps://string-db.org/network/511145.b3856Molybdopterin-guanine dinucleotide biosynthesis protein B; GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necess [...]
mobA protein networkhttps://string-db.org/network/511145.b3857Molybdopterin-guanine dinucleotide synthase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo- [...]
yihD protein networkhttps://string-db.org/network/511145.b3858DUF1040 protein YihD; To H.influenzae HI_0845.
srkA protein networkhttps://string-db.org/network/511145.b3859Cpx stress response Thr/Ser protein kinase; A protein kinase that (auto)phosphorylates on Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive [...]
dsbA protein networkhttps://string-db.org/network/511145.b3860Periplasmic protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and i [...]
yihF protein networkhttps://string-db.org/network/511145.b3861DUF945 family protein; Putative GTP-binding protein; To E.coli YdgA and H.influenzae HI_1236.
yihG protein networkhttps://string-db.org/network/511145.b3862Inner membrane protein, inner membrane acyltransferase; Putative endonuclease.
polA protein networkhttps://string-db.org/network/511145.b38635' to 3' DNA polymerase and 3' to 5'/5' to 3' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is able to utilize nicked circ [...]
yihA protein networkhttps://string-db.org/network/511145.b3865Cell division GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation. Depletion of this protein leads to a severe reduction in growth rate and to exte [...]
yihI protein networkhttps://string-db.org/network/511145.b3866Activator of Der GTPase; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function, negatively regulating cell growth, probably via ribosome assembly. Stimulates the GTPase activit [...]
hemN protein networkhttps://string-db.org/network/511145.b3867Coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent; Involved in the heme biosynthesis. Catalyzes the anaerobic oxidative decarboxylation of propionate groups of rings A [...]
glnG protein networkhttps://string-db.org/network/511145.b3868DNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limita [...]
glnL protein networkhttps://string-db.org/network/511145.b3869Sensory histidine kinase in two-component regulatory system with GlnG; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in [...]
glnA protein networkhttps://string-db.org/network/511145.b3870Glutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
typA protein networkhttps://string-db.org/network/511145.b3871GTP-binding protein; A 50S ribosomal subunit assembly protein with GTPase and nucleotide-independent chaperone activity. Genetic and deletion evidence suggests this is involved in ribosome assemb [...]
yihL protein networkhttps://string-db.org/network/511145.b3872Putative transcriptional regulator; Protein involved in transcription repressor activity and transcription.
yihM protein networkhttps://string-db.org/network/511145.b3873Putative sugar phosphate isomerase.
yihN protein networkhttps://string-db.org/network/511145.b3874MFS transporter family protein; Putative resistance protein (transport); Belongs to the major facilitator superfamily.
ompL protein networkhttps://string-db.org/network/511145.b3875Outer membrane porin L; Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate re [...]
yihO protein networkhttps://string-db.org/network/511145.b3876Putative sulphoquinovose importer; Could be involved in sulfoquinovose import.
yihP protein networkhttps://string-db.org/network/511145.b3877Putative 2,3-dihydroxypropane-1-sulphonate exporter, membrane protein; Could be involved in the export of 2,3-dihydroxypropane-1- sulfonate (DHPS); Belongs to the sodium:galactoside symporter (TC [...]
yihQ protein networkhttps://string-db.org/network/511145.b3878Putative sulpholipid alpha-glucosidase; Catalyzes the hydrolysis of sulfoquinovosyl diacylglycerides (SQDG) to sulfoquinovose (SQ), which is then degraded by E.coli through the SQ Embden-Meyerhof [...]
yihR protein networkhttps://string-db.org/network/511145.b3879Putative sulphoquinovose mutarotase; Putative aldose-1-epimerase.
yihS protein networkhttps://string-db.org/network/511145.b3880Sulphoquinovose isomerase; Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF). In vitro, can also catalyze the interconversion of mannose, fructose and glucose [...]
yihT protein networkhttps://string-db.org/network/511145.b38816-deoxy-6-sulphofructose-1-phosphate aldolase; Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). Belongs to the aldolas [...]
yihU protein networkhttps://string-db.org/network/511145.b38823-sulpholactaldehyde (SLA) reductase, NADH-dependent; Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1- sulfonate (DHPS).
yihV protein networkhttps://string-db.org/network/511145.b38836-deoxy-6-sulphofructose kinase; Phosphorylates 6-deoxy-6-sulfo-D-fructose (SF) to 6-deoxy-6- sulfo-D-fructose 1-phosphate (SFP); Belongs to the carbohydrate kinase PfkB family.
yihW protein networkhttps://string-db.org/network/511145.b3884Putative transcriptional regulator for sulphoquinovose utilization; Involved in the regulation of the sulfoquinovose operon. Represses the expression of the yihUTS operon and of the yihV and csqR [...]
yihX protein networkhttps://string-db.org/network/511145.b3885alpha-D-glucose-1-phosphate phosphatase, anomer-specific; Catalyzes the dephosphorylation of alpha-D-glucose 1- phosphate (Glc1P) and, to a lesser extent, of other sugar phosphates. Has no activi [...]
yihY protein networkhttps://string-db.org/network/511145.b3886BrkB family putative transporter, inner membrane protein; tRNA processing exoribonuclease BN.
dtd protein networkhttps://string-db.org/network/511145.b3887D-tyr-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs, has no observable editing activity on tRNAs charged with cognate L-amino acid. Edits misc [...]
yiiD protein networkhttps://string-db.org/network/511145.b3888GNAT family putative N-acetyltransferase; Putative acetyltransferase.
yiiE protein networkhttps://string-db.org/network/511145.b3889CopG family putative transcriptional regulator; Belongs to the YiiE family.
yiiF protein networkhttps://string-db.org/network/511145.b3890Putative thymol sensitivity protein, CopG family putative transcriptional regulator; To E.coli YiiE.
fdhE protein networkhttps://string-db.org/network/511145.b3891Formate dehydrogenase formation protein; Necessary for formate dehydrogenase activity.
fdoI protein networkhttps://string-db.org/network/511145.b3892Formate dehydrogenase-O, cytochrome b556 subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the for [...]
fdoH protein networkhttps://string-db.org/network/511145.b3893Formate dehydrogenase-O, Fe-S subunit; Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involve [...]
fdoG protein networkhttps://string-db.org/network/511145.b3894Formate dehydrogenase-O, large subunit; Allows to use formate as major electron donor during aerobic respiration. Subunit alpha possibly forms the active site; Belongs to the prokaryotic molybdop [...]
fdhD protein networkhttps://string-db.org/network/511145.b3895Formate dehydrogenase formation protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to it [...]
yiiG protein networkhttps://string-db.org/network/511145.b3896DUF3829 family lipoprotein.
frvR protein networkhttps://string-db.org/network/511145.b3897Putative frv operon regulator; Could be involved in the regulation of the transcription of the FRV operon.
frvX protein networkhttps://string-db.org/network/511145.b3898Putative peptidase; Frv operon protein; Protein involved in polysaccharide catabolic process.
frvB protein networkhttps://string-db.org/network/511145.b3899Putative PTS enzyme, IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosph [...]
frvA protein networkhttps://string-db.org/network/511145.b3900Putative enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of [...]
rhaM protein networkhttps://string-db.org/network/511145.b3901L-rhamnose mutarotase; Involved in the anomeric conversion of L-rhamnose.
rhaD protein networkhttps://string-db.org/network/511145.b3902Rhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Also catalyzes the dephosphorylation of pho [...]
rhaA protein networkhttps://string-db.org/network/511145.b3903L-rhamnose isomerase; Protein involved in carbohydrate catabolic process.
rhaB protein networkhttps://string-db.org/network/511145.b3904Rhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). It could also play a role in the metabolism of some rare sugars such as L-fructose. Catalyzes the transfer of the gam [...]
rhaS protein networkhttps://string-db.org/network/511145.b3905Transcriptional activator of rhaBAD and rhaT; Activates expression of the rhaBAD and rhaT operons.
rhaR protein networkhttps://string-db.org/network/511145.b3906Transcriptional activator of rhaSR; Activates expression of the rhaSR operon in response to L- rhamnose.
rhaT protein networkhttps://string-db.org/network/511145.b3907L-rhamnose:proton symporter; Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-mannose and L-xylose, [...]
sodA protein networkhttps://string-db.org/network/511145.b3908Superoxide dismutase, Mn; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismu [...]
kdgT protein networkhttps://string-db.org/network/511145.b39092-keto-3-deoxy-D-gluconate transporter; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This i [...]
yiiM protein networkhttps://string-db.org/network/511145.b39106-N-hydroxylaminopurine resistance protein.
cpxA protein networkhttps://string-db.org/network/511145.b3911Sensory histidine kinase in two-component regulatory system with CpxR; Histidine kinase member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activ [...]
cpxR protein networkhttps://string-db.org/network/511145.b3912Response regulator in two-component regulatory system with CpxA; Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activatin [...]
fieF protein networkhttps://string-db.org/network/511145.b3915Ferrous iron and zinc transporter; Iron-efflux transporter responsible for iron detoxification. Also able to transport Zn(2+) in a proton-dependent manner. Belongs to the cation diffusion facilit [...]
pfkA protein networkhttps://string-db.org/network/511145.b39166-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase t [...]
sbp protein networkhttps://string-db.org/network/511145.b3917Sulfate transporter subunit; This protein specifically binds sulfate and is involved in its transmembrane transport.
cdh protein networkhttps://string-db.org/network/511145.b3918CDP-diacylglycerol phosphotidylhydrolase.
tpiA protein networkhttps://string-db.org/network/511145.b3919Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the [...]
yiiQ protein networkhttps://string-db.org/network/511145.b3920DUF1454 family putative periplasmic protein.
yiiR protein networkhttps://string-db.org/network/511145.b3921DUF805 family putative inner membrane protein.
yiiS protein networkhttps://string-db.org/network/511145.b3922UPF0381 family protein; Belongs to the UPF0381 family.
uspD protein networkhttps://string-db.org/network/511145.b3923Stress-induced protein; Required for resistance to DNA-damaging agents.
fpr protein networkhttps://string-db.org/network/511145.b3924ferredoxin-NADP reductase; Transports electrons between flavodoxin or ferredoxin and NADPH. Reduces flavodoxin 1, flavodoxin 2 and ferredoxin, ferredoxin being the kinetically and thermodynamical [...]
glpX protein networkhttps://string-db.org/network/511145.b3925Fructose 1,6-bisphosphatase II; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Is likely to be involved in gluconeogenesis during growth on glycerol. Also displays [...]
glpK protein networkhttps://string-db.org/network/511145.b3926Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. It also catalyzes the phosphorylation [...]
glpF protein networkhttps://string-db.org/network/511145.b3927Glycerol facilitator; Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols; Belongs to the MIP/aquaporin (TC 1 [...]
zapB protein networkhttps://string-db.org/network/511145.b3928FtsZ stabilizer, septal ring assembly factor, cell division stimulator; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the div [...]
rraA protein networkhttps://string-db.org/network/511145.b3929Ribonuclease E (RNase E) inhibitor protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-depend [...]
menA protein networkhttps://string-db.org/network/511145.b39301,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side c [...]
hslU protein networkhttps://string-db.org/network/511145.b3931Molecular chaperone and ATPase component of HslUV protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hyd [...]
hslV protein networkhttps://string-db.org/network/511145.b3932Peptidase component of the HslUV protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involve [...]
ftsN protein networkhttps://string-db.org/network/511145.b3933Essential cell division protein; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction wi [...]
cytR protein networkhttps://string-db.org/network/511145.b3934Anti-activator for CytR-CRP nucleoside utilization regulon; This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and [...]
priA protein networkhttps://string-db.org/network/511145.b3935Primosome factor n' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the [...]
rpmE protein networkhttps://string-db.org/network/511145.b393650S ribosomal subunit protein L31; Binds the 23S rRNA.
yiiX protein networkhttps://string-db.org/network/511145.b3937Putative lipid binding hydrolase, DUF830 family protein; To E.coli YebB.
metJ protein networkhttps://string-db.org/network/511145.b3938Transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes [...]
metB protein networkhttps://string-db.org/network/511145.b3939Cystathionine gamma-synthase, PLP-dependent; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of th [...]
metL protein networkhttps://string-db.org/network/511145.b3940Bifunctional aspartokinase/homoserine dehydrogenase 2; Aspartokinase II and homoserine dehydrogenase II; Protein involved in methionine biosynthetic process and homoserine biosynthetic process.
metF protein networkhttps://string-db.org/network/511145.b39415,10-methylenetetrahydrofolate reductase; Methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine.
katG protein networkhttps://string-db.org/network/511145.b3942Catalase-peroxidase HPI, heme b-containing; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, INH lyase and isonicotinoyl-NAD synthase act [...]
yijE protein networkhttps://string-db.org/network/511145.b3943EamA-like transporter family protein; Involved in response to cystine. Overexpression confers tolerance to excess cystine; Belongs to the EamA transporter family.
yijF protein networkhttps://string-db.org/network/511145.b3944DUF1287 family protein.
gldA protein networkhttps://string-db.org/network/511145.b3945Glycerol dehydrogenase, NAD+ dependent; Catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone (glycerone). Allows microorganisms to utilize glycerol as a source of carbon under an [...]
fsaB protein networkhttps://string-db.org/network/511145.b3946Fructose-6-phosphate aldolase 2; Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize hydrox [...]
frwA protein networkhttps://string-db.org/network/511145.b3947Putative PTS enzyme: Hpr, enzyme I and II components; Multifunctional protein that includes general (non sugar- specific) and sugar-specific components of the phosphoenolpyruvate- dependent sugar [...]
frwC protein networkhttps://string-db.org/network/511145.b3949Putative enzyme IIC component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of inco [...]
frwB protein networkhttps://string-db.org/network/511145.b3950Putative enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of [...]
pflD protein networkhttps://string-db.org/network/511145.b3951Putative glycine radical domain-containing pyruvate formate-lyase; Probably shows dehydratase activity. Belongs to the glycyl radical enzyme (GRE) family.
pflC protein networkhttps://string-db.org/network/511145.b3952Putative [formate-C-acetyltransferase 2]-activating enzyme; Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine [...]
frwD protein networkhttps://string-db.org/network/511145.b3953Putative enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of [...]
yijO protein networkhttps://string-db.org/network/511145.b3954Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
eptC protein networkhttps://string-db.org/network/511145.b3955LPS heptose I phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core; Belongs to the phosphoethanolamine transferase [...]
ppc protein networkhttps://string-db.org/network/511145.b3956Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
argE protein networkhttps://string-db.org/network/511145.b3957Acetylornithine deacetylase; Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.
argC protein networkhttps://string-db.org/network/511145.b3958N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the [...]
argB protein networkhttps://string-db.org/network/511145.b3959Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
argH protein networkhttps://string-db.org/network/511145.b3960Argininosuccinate lyase; Protein involved in arginine biosynthetic process.
oxyR protein networkhttps://string-db.org/network/511145.b3961Oxidative and nitrosative stress transcriptional regulator; Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxy [...]
sthA protein networkhttps://string-db.org/network/511145.b3962Pyridine nucleotide transhydrogenase, soluble; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
fabR protein networkhttps://string-db.org/network/511145.b3963Transcriptional repressor of fabA and fabB; Binds the promoter region of at least fabA and fabB, but probably not yqfA. Represses the transcription of fabA and fabB, involved in unsaturated fatty [...]
yijD protein networkhttps://string-db.org/network/511145.b3964DUF1422 family inner membrane protein.
trmA protein networkhttps://string-db.org/network/511145.b3965tRNA m(5)U54 methyltransferase, SAM-dependent; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5 [...]
btuB protein networkhttps://string-db.org/network/511145.b3966Vitamin B12/cobalamin outer membrane transporter; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy fo [...]
murI protein networkhttps://string-db.org/network/511145.b3967Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. Belongs to the aspartate/glutamate racemases family.
murB protein networkhttps://string-db.org/network/511145.b3972UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding; Cell wall formation; Belongs to the MurB family.
birA protein networkhttps://string-db.org/network/511145.b3973Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5 [...]
coaA protein networkhttps://string-db.org/network/511145.b3974Pantothenate kinase; Protein involved in coenzyme A biosynthetic process; Belongs to the prokaryotic pantothenate kinase family.
tufB protein networkhttps://string-db.org/network/511145.b3980Translation elongation factor EF-Tu 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans [...]
secE protein networkhttps://string-db.org/network/511145.b3981Preprotein translocase membrane subunit; Essential subunit of the protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. Ov [...]
nusG protein networkhttps://string-db.org/network/511145.b3982Transcription termination factor; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polym [...]
rplK protein networkhttps://string-db.org/network/511145.b398350S ribosomal subunit protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
rplA protein networkhttps://string-db.org/network/511145.b398450S ribosomal subunit protein L1; One of the primary rRNA binding proteins, it binds very close to the 3'-end of the 23S rRNA. Forms part of the L1 stalk. It is often not seen in high-resolution [...]
rplJ protein networkhttps://string-db.org/network/511145.b398550S ribosomal subunit protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal riboso [...]
rplL protein networkhttps://string-db.org/network/511145.b398650S ribosomal subunit protein L7/L12; The binding site for several of the GTPase factors involved in protein synthesis (IF-2, EF-Tu, EF-G and RF3). Is thus essential for accurate translation. Del [...]
rpoB protein networkhttps://string-db.org/network/511145.b3987RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
rpoC protein networkhttps://string-db.org/network/511145.b3988RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
yjaZ protein networkhttps://string-db.org/network/511145.b3989Stationary phase growth adaptation protein; Heat shock protein htrC; Protein involved in response to temperature stimulus.
thiH protein networkhttps://string-db.org/network/511145.b3990Tyrosine lyase, involved in thiamine-thiazole moiety synthesis; Catalyzes the radical-mediated cleavage of tyrosine to 2- iminoacetate and 4-cresol.
thiG protein networkhttps://string-db.org/network/511145.b3991Thiamine biosynthesis ThiGH complex subunit; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the th [...]
thiF protein networkhttps://string-db.org/network/511145.b3992Adenylyltransferase, modifies ThiS C-terminus; Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS; Belongs to the HesA/MoeB/ThiF famil [...]
thiE protein networkhttps://string-db.org/network/511145.b3993Thiamine phosphate synthase (thiamine phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophos [...]
thiC protein networkhttps://string-db.org/network/511145.b3994Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methioni [...]
rsd protein networkhttps://string-db.org/network/511145.b3995Stationary phase protein, binds sigma 70 RNA polymerase subunit; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma [...]
nudC protein networkhttps://string-db.org/network/511145.b3996NADH pyrophosphatase; Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates, but uniquely prefers the reduced form of NADH.
hemE protein networkhttps://string-db.org/network/511145.b3997Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
nfi protein networkhttps://string-db.org/network/511145.b3998Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the int [...]
yjaG protein networkhttps://string-db.org/network/511145.b3999DUF416 domain protein; To H.influenzae HI_0431.
hupA protein networkhttps://string-db.org/network/511145.b4000HU, DNA-binding transcriptional regulator, alpha subunit; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme env [...]
yjaH protein networkhttps://string-db.org/network/511145.b4001DUF1481 family putative lipoprotein.
zraP protein networkhttps://string-db.org/network/511145.b4002Zn-dependent periplasmic chaperone; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family.
zraS protein networkhttps://string-db.org/network/511145.b4003Sensory histidine kinase in two-component regulatory system with ZraR; Member of the two-component regulatory system ZraS/ZraR. May function as a membrane-associated protein kinase that phosphory [...]
zraR protein networkhttps://string-db.org/network/511145.b4004Transcriptional regulatory protein ZraR; Member of the two-component regulatory system ZraS/ZraR. When activated by ZraS it acts in conjunction with sigma-54 to regulate the expression of zraP. P [...]
purD protein networkhttps://string-db.org/network/511145.b4005Phosphoribosylglycinamide synthetase = GAR synthetase; Protein involved in purine nucleotide biosynthetic process; Belongs to the GARS family.
purH protein networkhttps://string-db.org/network/511145.b4006IMP cyclohydrolase and phosphoribosylaminoimidazolecarboxamide formyltransferase; Protein involved in purine nucleotide biosynthetic process and nucleobase, nucleoside and nucleotide interconvers [...]
yjaA protein networkhttps://string-db.org/network/511145.b4011Stress-induced protein.
yjaB protein networkhttps://string-db.org/network/511145.b4012GNAT-family putative N-acetyltransferase; N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins. Binds acetyl-CoA ; Belongs to the acetyltransferase family.
metA protein networkhttps://string-db.org/network/511145.b4013Homoserine O-transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the succinyl group of s [...]
aceB protein networkhttps://string-db.org/network/511145.b4014Malate synthase A; Protein involved in glyoxylate cycle.
aceA protein networkhttps://string-db.org/network/511145.b4015Isocitrate lyase; Involved in the metabolic adaptation in response to environmental changes. Catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyo [...]
aceK protein networkhttps://string-db.org/network/511145.b4016Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mecha [...]
arpA protein networkhttps://string-db.org/network/511145.b4017Ankyrin repeat protein.
iclR protein networkhttps://string-db.org/network/511145.b4018Transcriptional repressor; Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylat [...]
metH protein networkhttps://string-db.org/network/511145.b4019homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methi [...]
yjbB protein networkhttps://string-db.org/network/511145.b4020Putative alpha helix protein.
pepE protein networkhttps://string-db.org/network/511145.b4021Peptidase E, alpha-aspartyl dipeptidase; Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise re [...]
rluF protein networkhttps://string-db.org/network/511145.b402223S rRNA pseudouridine(2604) synthase; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-2604 in 23S ribosomal RNA and from uracil-35 in the anticodon of tRNA(Tyr) [...]
yjbD protein networkhttps://string-db.org/network/511145.b4023DUF3811 family protein.
lysC protein networkhttps://string-db.org/network/511145.b4024Lysine-sensitive aspartokinase 3; Aspartokinase III, lysine sensitive; Protein involved in lysine biosynthetic process via diaminopimelate and homoserine biosynthetic process.
pgi protein networkhttps://string-db.org/network/511145.b4025Glucosephosphate isomerase; Protein involved in glycolysis and gluconeogenesis; Belongs to the GPI family.
yjbE protein networkhttps://string-db.org/network/511145.b4026Extracellular polysaccharide production threonine-rich protein.
yjbF protein networkhttps://string-db.org/network/511145.b4027Extracellular polysaccharide production lipoprotein.
yjbG protein networkhttps://string-db.org/network/511145.b4028Extracellular polysaccharide export OMA protein; To E.coli YmcB.
yjbH protein networkhttps://string-db.org/network/511145.b4029DUF940 family extracellular polysaccharide protein.
psiE protein networkhttps://string-db.org/network/511145.b4030Phosphate starvation inducible protein; Belongs to the PsiE family.
xylE protein networkhttps://string-db.org/network/511145.b4031D-xylose transporter; Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Glucose is not transported, but can compete for xyl [...]
malG protein networkhttps://string-db.org/network/511145.b4032Maltose transporter subunit; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
malF protein networkhttps://string-db.org/network/511145.b4033Maltose transporter subunit; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
malE protein networkhttps://string-db.org/network/511145.b4034Maltose transporter subunit; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose. Belongs to the bacter [...]
malK protein networkhttps://string-db.org/network/511145.b4035Maltose ABC transportor ATPase; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC tr [...]
lamB protein networkhttps://string-db.org/network/511145.b4036Maltose outer membrane porin (maltoporin); Involved in the transport of maltose and maltodextrins, indispensable for translocation of dextrins containing more than three glucosyl moieties. A hydr [...]
malM protein networkhttps://string-db.org/network/511145.b4037Maltose regulon periplasmic protein; Not yet known. Might function in the uptake of a still unidentified substrate; To S.typhimurium MalM.
ubiC protein networkhttps://string-db.org/network/511145.b4039Chorismate pyruvate-lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
ubiA protein networkhttps://string-db.org/network/511145.b4040P-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubi [...]
plsB protein networkhttps://string-db.org/network/511145.b4041Glycerol-3-phosphate O-acyltransferase; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can utilize either acy [...]
dgkA protein networkhttps://string-db.org/network/511145.b4042Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
lexA protein networkhttps://string-db.org/network/511145.b4043Transcriptional repressor of SOS regulon; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CT [...]
dinF protein networkhttps://string-db.org/network/511145.b4044Oxidative stress resistance protein; DNA-damage-inducible protein F; Protein involved in DNA repair, response to radiation and SOS response; Belongs to the multi antimicrobial extrusion (MATE) (T [...]
yjbJ protein networkhttps://string-db.org/network/511145.b4045Stress-induced protein, UPF0337 family; Belongs to the UPF0337 (CsbD) family.
zur protein networkhttps://string-db.org/network/511145.b4046Transcriptional repressor, Zn(II)-binding; Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes (znuACB); Belongs to the Fur family.
yjbL protein networkhttps://string-db.org/network/511145.b4047Uncharacterized protein.
yjbM protein networkhttps://string-db.org/network/511145.b4048Uncharacterized protein.
dusA protein networkhttps://string-db.org/network/511145.b4049tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines [...]
pspG protein networkhttps://string-db.org/network/511145.b4050Phage shock protein G; Effector of the phage shock response.
qorA protein networkhttps://string-db.org/network/511145.b4051Quinone oxidoreductase, NADPH-dependent; Quinone oxidoreductase; Protein involved in electron carrier activity.
dnaB protein networkhttps://string-db.org/network/511145.b4052Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DN [...]
alr protein networkhttps://string-db.org/network/511145.b4053Alanine racemase, biosynthetic, PLP-binding; Catalyzes the interconversion of L-alanine and D-alanine. Provides the D-alanine required for cell wall biosynthesis.
tyrB protein networkhttps://string-db.org/network/511145.b4054Tyrosine aminotransferase, tyrosine-repressible, PLP-dependent; Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yie [...]
aphA protein networkhttps://string-db.org/network/511145.b4055Acid phosphatase/phosphotransferase, class B, non-specific; Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate [...]
yjbQ protein networkhttps://string-db.org/network/511145.b4056Thiamine phosphate synthase; Belongs to the UPF0047 family.
yjbR protein networkhttps://string-db.org/network/511145.b4057DUF419 family protein.
uvrA protein networkhttps://string-db.org/network/511145.b4058ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase an [...]
ssb protein networkhttps://string-db.org/network/511145.b4059Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of act [...]
yjcB protein networkhttps://string-db.org/network/511145.b4060Putative inner membrane protein.
yjcC protein networkhttps://string-db.org/network/511145.b4061Putative membrane-anchored cyclic-di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic-di-GMP (c-di-GMP) to 5'-pGpG (By similarity). Cyclic-di-GMP is a second [...]
soxS protein networkhttps://string-db.org/network/511145.b4062Superoxide response regulon transcriptional activator; Transcriptional activator of the superoxide response regulon of E.coli that includes at least 10 genes such as sodA, nfo, zwf and micF. Bind [...]
soxR protein networkhttps://string-db.org/network/511145.b4063Redox-sensitive transcriptional activator of soxS; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster [...]
ghxP protein networkhttps://string-db.org/network/511145.b4064Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine.
yjcE protein networkhttps://string-db.org/network/511145.b4065Putative cation/proton antiporter.
yjcF protein networkhttps://string-db.org/network/511145.b4066Pentapeptide repeats protein.
actP protein networkhttps://string-db.org/network/511145.b4067Acetate transporter; Transports acetate. Also able to transport glycolate.
yjcH protein networkhttps://string-db.org/network/511145.b4068DUF485 family inner membrane protein.
acs protein networkhttps://string-db.org/network/511145.b4069acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction [...]
nrfA protein networkhttps://string-db.org/network/511145.b4070Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process. Has very low activity toward hydroxylamine. Has even lower [...]
nrfB protein networkhttps://string-db.org/network/511145.b4071Nitrite reductase, formate-dependent, penta-heme cytochrome c; Plays a role in nitrite reduction.
nrfC protein networkhttps://string-db.org/network/511145.b4072Formate-dependent nitrite reductase, 4Fe4S subunit; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.
nrfD protein networkhttps://string-db.org/network/511145.b4073Formate-dependent nitrite reductase, membrane subunit; Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes; Belongs to the NrfD family.
nrfE protein networkhttps://string-db.org/network/511145.b4074Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfE; May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
nrfF protein networkhttps://string-db.org/network/511145.b4075Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Not required for the biosynthesis of any of the c-type cytochromes. Possible subunit of a heme lyase.
nrfG protein networkhttps://string-db.org/network/511145.b4076Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfG; Required for formate-dependent nitrite reduction. Not required for the biosynthesis of any of the c-type cytochromes nor for the [...]
gltP protein networkhttps://string-db.org/network/511145.b4077Glutamate/aspartate:proton symporter; Catalyzes the proton-dependent, binding-protein-independent transport of glutamate and aspartate. Belongs to the dicarboxylate/amino acid:cation symporter (D [...]
yjcO protein networkhttps://string-db.org/network/511145.b4078Sel1 family TPR-like repeat protein.
fdhF protein networkhttps://string-db.org/network/511145.b4079Formate dehydrogenase-H, selenopolypeptide subunit; Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors.
mdtP protein networkhttps://string-db.org/network/511145.b4080Outer membrane factor of efflux pump; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
mdtO protein networkhttps://string-db.org/network/511145.b4081Membrane translocase (MDR) of MdtNOP efflux pump, PET family; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride.
mdtN protein networkhttps://string-db.org/network/511145.b4082Membrane fusion protein of efflux pump; Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
yjcS protein networkhttps://string-db.org/network/511145.b4083Metallo-beta-lactamase superfamily protein; Protein involved in sulfur metabolic process; Belongs to the metallo-beta-lactamase superfamily.
alsK protein networkhttps://string-db.org/network/511145.b4084D-allose kinase; Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate. Has also low level glucokinase activity in vitro. Belongs to the ROK (NagC/XylR) family.
alsE protein networkhttps://string-db.org/network/511145.b4085Allulose-6-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization [...]
alsC protein networkhttps://string-db.org/network/511145.b4086D-allose ABC transporter permease; Part of the binding-protein-dependent transport system AlsBAC for D-allose; probably responsible for the translocation of the substrate across the membrane; Bel [...]
alsA protein networkhttps://string-db.org/network/511145.b4087D-allose ABC transporter ATPase; Part of the ABC transporter complex AlsBAC involved in D- allose import. Probably responsible for energy coupling to the transport system; Belongs to the ABC tran [...]
alsB protein networkhttps://string-db.org/network/511145.b4088D-allose ABC transporter periplasmic binding protein; Part of the binding-protein-dependent transport system AlsBAC for D-allose; Belongs to the bacterial solute-binding protein 2 family.
alsR protein networkhttps://string-db.org/network/511145.b4089D-allose-inducible als operon transcriptional repressor; Regulatory protein involved in rpiB gene repression. Also involved in als operon repression.
rpiB protein networkhttps://string-db.org/network/511145.b4090Ribose 5-phosphate isomerase B/allose 6-phosphate isomerase; Catalyzes the interconversion of ribulose-5-P and ribose-5-P. It probably also has activity on D-allose 6-phosphate.
phnP protein networkhttps://string-db.org/network/511145.b40925-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase; Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate.
phnO protein networkhttps://string-db.org/network/511145.b4093Aminoalkylphosphonate N-acetyltransferase; Aminoalkylphosphonate N-acetyltransferase which is able to acetylate a range of aminoalkylphosphonic acids, including aminomethylphosphonate, (S)-1-amin [...]
phnN protein networkhttps://string-db.org/network/511145.b4094Ribose 1,5-bisphosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). Accepts ATP but not GTP as a phosphoryl donor, and uses ri [...]
phnM protein networkhttps://string-db.org/network/511145.b4095Ribophosphonate triphosphate hydrolase; Catalyzes the hydrolysis of alpha-D-ribose 1- methylphosphonate triphosphate (RPnTP) to form alpha-D-ribose 1- methylphosphonate phosphate (PRPn) and dipho [...]
phnL protein networkhttps://string-db.org/network/511145.b4096Ribophosphonate triphosphate synthase subunit; Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate; Belongs to the ABC [...]
phnK protein networkhttps://string-db.org/network/511145.b4097Carbon-phosphorus lyase complex subunit, putative ATP transporter ATP-binding protein; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. PhnK is no [...]
phnJ protein networkhttps://string-db.org/network/511145.b4098Carbon-phosphorus lyase, SAM-dependent; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose 1,2-cyclic phosphate 5-phosphate (P [...]
phnI protein networkhttps://string-db.org/network/511145.b4099Ribophosphonate triphosphate synthase complex putative catalytic subunit; Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosp [...]
phnH protein networkhttps://string-db.org/network/511145.b4100Ribophosphonate triphosphate synthase subunit; Together with PhnG, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.
phnG protein networkhttps://string-db.org/network/511145.b4101Ribophosphonate triphosphate synthase subunit; Together with PhnH, PhnI and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.
phnF protein networkhttps://string-db.org/network/511145.b4102Putative DNA-binding transcriptional regulator of phosphonate uptake and biodegradation; Belongs to an operon involved in alkylphosphonate uptake and C-P lyase. Exact function not known. By simil [...]
phnD protein networkhttps://string-db.org/network/511145.b4105Phosphonates-binding periplasmic protein; Phosphonate binding protein that is part of the phosphonate uptake system. Exhibits high affinity for 2-aminoethylphosphonate, and somewhat less affinity [...]
phnC protein networkhttps://string-db.org/network/511145.b4106Phosphonate ABC transporter ATPase; Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the t [...]
yjdN protein networkhttps://string-db.org/network/511145.b4107Metalloprotein superfamily protein.
yjdM protein networkhttps://string-db.org/network/511145.b4108Zinc-ribbon family protein.
crfC protein networkhttps://string-db.org/network/511145.b4109Clamp-binding sister replication fork colocalization protein, dynamin-related; Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication [...]
yjcZ protein networkhttps://string-db.org/network/511145.b4110YjcZ family protein; yhjH motility defect suppressor.
proP protein networkhttps://string-db.org/network/511145.b4111Proline/glycine betaine transporter; Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and tau [...]
basS protein networkhttps://string-db.org/network/511145.b4112Sensory histidine kinase in two-component regulatory system with BasR; Member of the two-component regulatory system BasS/BasR Autophosphorylates and activates BasR by phosphorylation.
basR protein networkhttps://string-db.org/network/511145.b4113Response regulator in two-component regulatory system with BasS; Member of the two-component regulatory system BasS/BasR. BasR induces the transcription of the ugd, ais, arnBCADTEF and eptA-basRS [...]
eptA protein networkhttps://string-db.org/network/511145.b4114Lipid A phosphoethanolamine transferase; Catalyzes the addition of a phosphoethanolamine moiety to the lipid A. The phosphoethanolamine modification is required for resistance to polymyxin; Belon [...]
adiC protein networkhttps://string-db.org/network/511145.b4115Arginine:agmatine antiporter; Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach (By similarity). Exchanges extracellul [...]
adiY protein networkhttps://string-db.org/network/511145.b4116Adi system transcriptional activator; Putative ARAC-type regulatory protein; Protein involved in transcription activator activity and transcription.
adiA protein networkhttps://string-db.org/network/511145.b4117Arginine decarboxylase; ADC can be found in two forms: biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins; Belongs to the Orn/Lys/Arg [...]
melR protein networkhttps://string-db.org/network/511145.b4118Melibiose operon transcriptional regulator; Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site.
melA protein networkhttps://string-db.org/network/511145.b4119Alpha-galactosidase, NAD(P)-binding; Alpha-galactosidase; Protein involved in carbohydrate catabolic process and NAD biosynthetic process; Belongs to the glycosyl hydrolase 4 family.
melB protein networkhttps://string-db.org/network/511145.b4120Melibiose:sodium symporter; Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending [...]
yjdF protein networkhttps://string-db.org/network/511145.b4121DUF2238 family inner membrane protein.
fumB protein networkhttps://string-db.org/network/511145.b4122Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Functions in the generation of fumarate for use as an anaerobic electron acceptor. [...]
dcuB protein networkhttps://string-db.org/network/511145.b4123C4-dicarboxylate transporter, anaerobic; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family [...]
dcuR protein networkhttps://string-db.org/network/511145.b4124Response regulator in two-component regulatory system with DcuS; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encod [...]
dcuS protein networkhttps://string-db.org/network/511145.b4125Sensor histidine kinase DcuS; Member of the two-component regulatory system DcuR/DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respirat [...]
yjdI protein networkhttps://string-db.org/network/511145.b4126Putative 4Fe-4S mono-cluster protein.
yjdJ protein networkhttps://string-db.org/network/511145.b4127GNAT family putative N-acetyltransferase.
ghoS protein networkhttps://string-db.org/network/511145.b4128Antitoxin of GhoTS toxin-antitoxin pair; Antitoxin component of a type V toxin-antitoxin (TA) system. Neutralizes the toxic effects of toxin GhoT by digesting ghoT transcripts in a sequence-speci [...]
lysU protein networkhttps://string-db.org/network/511145.b4129Lysine tRNA synthetase, inducible; Also can synthesize a number of adenyl dinucleotides (in particular AppppA). These dinucleotides have been proposed to act as modulators of the heat-shock respo [...]
dtpC protein networkhttps://string-db.org/network/511145.b4130Dipeptide and tripeptide permease; Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for [...]
cadA protein networkhttps://string-db.org/network/511145.b4131Lysine decarboxylase, acid-inducible; Inducible lysine decarboxylase that catalyzes the proton- dependent decarboxylation of L-lysine to produce the polyamine cadaverine and carbon dioxide. Plays [...]
cadB protein networkhttps://string-db.org/network/511145.b4132Putative lysine/cadaverine transporter; Probable cadaverine/lysine antiporter or part of it.
cadC protein networkhttps://string-db.org/network/511145.b4133cadBA operon transcriptional activator; Required for Pcad induction, a promoter upstream of cadBA that is responsible for the pH-regulated expression of CadA and CadB. Probably acts as an activat [...]
yjdC protein networkhttps://string-db.org/network/511145.b4135tRNA-Phe; Anticodon: GAA.
dsbD protein networkhttps://string-db.org/network/511145.b4136Thiol:disulfide interchange protein and activator of DsbC; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-t [...]
cutA protein networkhttps://string-db.org/network/511145.b4137Divalent-cation tolerance protein, copper sensitivity; Involved in resistance toward heavy metals. Belongs to the CutA family.
dcuA protein networkhttps://string-db.org/network/511145.b4138C4-dicarboxylate antiporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
aspA protein networkhttps://string-db.org/network/511145.b4139Aspartate ammonia-lyase (aspartase); Protein involved in cellular amino acid metabolic process, asparagine biosynthetic process and lysine biosynthetic process via diaminopimelate.
fxsA protein networkhttps://string-db.org/network/511145.b4140Suppressor of F exclusion of phage T7; Overexpression alleviates the exclusion of phage T7 in cells harboring the F plasmid; Belongs to the UPF0716 (FxsA) family.
yjeH protein networkhttps://string-db.org/network/511145.b4141Putative transporter; Catalyzes the efflux of L-methionine. Can also export L- leucine, L-isoleucine and L-valine. Activity is dependent on electrochemical potential.
groS protein networkhttps://string-db.org/network/511145.b4142Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family.
groL protein networkhttps://string-db.org/network/511145.b4143Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
yjeI protein networkhttps://string-db.org/network/511145.b4144DUF4156 family lipoprotein.
yjeJ protein networkhttps://string-db.org/network/511145.b4145Uncharacterized protein.
epmB protein networkhttps://string-db.org/network/511145.b4146EF-P-Lys34 lysylation protein; With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. EpmB appears to act [...]
efp protein networkhttps://string-db.org/network/511145.b4147Polyproline-specific translation elongation factor EF-P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG i [...]
sugE protein networkhttps://string-db.org/network/511145.b4148Multidrug efflux system protein; Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons. Overexpression leads to resistanc [...]
blc protein networkhttps://string-db.org/network/511145.b4149Outer membrane lipoprotein cell division and growth lipocalin; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding pre [...]
ampC protein networkhttps://string-db.org/network/511145.b4150Penicillin-binding protein; This protein is a serine beta-lactamase with a substrate specificity for cephalosporins; Belongs to the class-C beta-lactamase family.
frdD protein networkhttps://string-db.org/network/511145.b4151Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane; Belongs t [...]
frdC protein networkhttps://string-db.org/network/511145.b4152Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.
frdB protein networkhttps://string-db.org/network/511145.b4153Fumarate reductase (anaerobic), Fe-S subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reduct [...]
frdA protein networkhttps://string-db.org/network/511145.b4154Anaerobic fumarate reductase catalytic and NAD/flavoprotein subunit; Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversi [...]
epmA protein networkhttps://string-db.org/network/511145.b4155Elongation Factor P Lys34 lysyltransferase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. Cataly [...]
yjeM protein networkhttps://string-db.org/network/511145.b4156Putative transport.
yjeN protein networkhttps://string-db.org/network/511145.b4157Uncharacterized protein.
yjeO protein networkhttps://string-db.org/network/511145.b4158Inner membrane protein.
mscM protein networkhttps://string-db.org/network/511145.b4159Mechanosensitive channel protein, miniconductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased [...]
psd protein networkhttps://string-db.org/network/511145.b4160Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Only decarboxylates the lipid-linked form of the serine moiety, an [...]
rsgA protein networkhttps://string-db.org/network/511145.b4161Ribosome small subunit-dependent GTPase A; One of at least 4 proteins (Era, RbfA, RimM and RsgA/YjeQ) that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. [...]
orn protein networkhttps://string-db.org/network/511145.b4162Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides 2 to 5 nucleotides in length, as well as small (2 to 5 nucleotides) ssDNA oligomers. Probably responsible for t [...]
queG protein networkhttps://string-db.org/network/511145.b4166Epoxyqueuosine reductase, cobalamine-stimulated; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(A [...]
nnr protein networkhttps://string-db.org/network/511145.b4167Bifunctional NAD(P)H-hydrate repair enzyme; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of [...]
tsaE protein networkhttps://string-db.org/network/511145.b4168tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginnin [...]
amiB protein networkhttps://string-db.org/network/511145.b4169N-acetylmuramoyl-l-alanine amidase II; Cell-wall hydrolase involved in septum cleavage during cell division. Can also act as powerful autolysin in the presence of murein synthesis inhibitors.
mutL protein networkhttps://string-db.org/network/511145.b4170Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular [...]
miaA protein networkhttps://string-db.org/network/511145.b4171Delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, lea [...]
hfq protein networkhttps://string-db.org/network/511145.b4172Global sRNA chaperone; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes [...]
hflX protein networkhttps://string-db.org/network/511145.b4173GTPase, stimulated by 50S subunit binding; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. In vitro, also exhibits ATPas [...]
hflK protein networkhttps://string-db.org/network/511145.b4174Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage [...]
hflC protein networkhttps://string-db.org/network/511145.b4175HflB protease modulator specific for phage lambda cII repressor; HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lam [...]
yjeT protein networkhttps://string-db.org/network/511145.b4176DUF2065 family protein.
purA protein networkhttps://string-db.org/network/511145.b4177Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to t [...]
nsrR protein networkhttps://string-db.org/network/511145.b4178Nitric oxide-sensitive repressor for NO regulon; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress, such as ytfE, hmpA and ygbA. May require iro [...]
rnr protein networkhttps://string-db.org/network/511145.b4179Exoribonuclease R, RNase R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (rRNAs, tRNAs and SsrA/tmRNA). In stationary phase, i [...]
rlmB protein networkhttps://string-db.org/network/511145.b418023S rRNA mG2251 2'-O-ribose methyltransferase, SAM-dependent; Specifically methylates the ribose of guanosine 2251 in 23S rRNA.
yjfI protein networkhttps://string-db.org/network/511145.b4181DUF2170 family protein.
yjfJ protein networkhttps://string-db.org/network/511145.b4182PspA/IM30 family protein; Putative alpha helical protein; Belongs to the PspA/IM30 family.
yjfK protein networkhttps://string-db.org/network/511145.b4183DUF2491 family protein.
yjfL protein networkhttps://string-db.org/network/511145.b4184UPF0719 family inner membrane protein.
yjfM protein networkhttps://string-db.org/network/511145.b4185DUF1190 family protein.
yjfC protein networkhttps://string-db.org/network/511145.b4186ATP-Grasp family ATPase; May be a ligase forming an amide bond. Shows ATPase activity. Despite its similarity to the C-terminal synthetase domain of Gss, is not a glutathionylspermidine (Gsp) syn [...]
aidB protein networkhttps://string-db.org/network/511145.b4187DNA alkylation damage repair protein; Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have y [...]
yjfN protein networkhttps://string-db.org/network/511145.b4188DUF1471 family periplasmic protein.
bsmA protein networkhttps://string-db.org/network/511145.b4189Bioflm peroxide resistance protein; Involved in protection of biofilms against oxidative stress. Belongs to the BhsA/McbA family.
yjfP protein networkhttps://string-db.org/network/511145.b4190Acyl CoA esterase; Displays esterase activity toward palmitoyl-CoA and pNP- butyrate.
ulaR protein networkhttps://string-db.org/network/511145.b4191Transcriptional repressor for the L-ascorbate utilization divergent operon; Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity re [...]
ulaG protein networkhttps://string-db.org/network/511145.b4192L-ascorbate 6-phosphate lactonase; Probably catalyzes the hydrolysis of L-ascorbate-6-P into 3- keto-L-gulonate-6-P. Is essential for L-ascorbate utilization under anaerobic conditions. Also show [...]
ulaA protein networkhttps://string-db.org/network/511145.b4193L-ascorbate-specific enzyme IIC permease component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes t [...]
ulaB protein networkhttps://string-db.org/network/511145.b4194L-ascorbate-specific enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosph [...]
ulaC protein networkhttps://string-db.org/network/511145.b4195L-ascorbate-specific enzyme IIA component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosph [...]
ulaD protein networkhttps://string-db.org/network/511145.b41963-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. Is involved in the anaerobic L-ascorbate utilization. Belongs to the HPS/K [...]
ulaE protein networkhttps://string-db.org/network/511145.b4197L-xylulose 5-phosphate 3-epimerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the L-ribulo [...]
ulaF protein networkhttps://string-db.org/network/511145.b4198L-ribulose 5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization; Belongs to the aldolase [...]
yjfY protein networkhttps://string-db.org/network/511145.b4199YhcN family protein, periplasmic.
rpsF protein networkhttps://string-db.org/network/511145.b420030S ribosomal subunit protein S6; Binds together with S18 to 16S ribosomal RNA.
priB protein networkhttps://string-db.org/network/511145.b4201Primosomal protein N; Binds single-stranded DNA at the primosome assembly site (PAS). During primosome assembly it facilitates the complex formation between PriA and DnaT. Belongs to the PriB fam [...]
rpsR protein networkhttps://string-db.org/network/511145.b420230S ribosomal subunit protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial [...]
rplI protein networkhttps://string-db.org/network/511145.b420350S ribosomal subunit protein L9; One of the primary rRNA binding proteins, it binds very close to the 3' end of the 23S rRNA; Belongs to the bacterial ribosomal protein bL9 family.
yjfZ protein networkhttps://string-db.org/network/511145.b4204Uncharacterized protein.
ytfB protein networkhttps://string-db.org/network/511145.b4206Cell division protein YtfB; Cell division protein whose function is related to the generation of a transient cell wall structure. Function is linked to the late stages of cell division.
fklB protein networkhttps://string-db.org/network/511145.b4207FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
cycA protein networkhttps://string-db.org/network/511145.b4208D-alanine/D-serine/glycine transporter; Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; Belongs to the amino acid-polyamine-organoca [...]
ytfE protein networkhttps://string-db.org/network/511145.b4209Iron-sulfur cluster repair protein RIC; Di-iron-containing protein involved in the repair of iron- sulfur clusters damaged by oxidative and nitrosative stress conditions.
ytfF protein networkhttps://string-db.org/network/511145.b4210DMT transporter family inner membrane protein; Putative transmembrane subunit.
qorB protein networkhttps://string-db.org/network/511145.b4211NAD(P)H:quinone oxidoreductase; Quinone oxidoreductase that may play some additional role beyond quinone reduction. Potential redox sensor protein. Overexpression induces retardation of growth.
ytfH protein networkhttps://string-db.org/network/511145.b4212DUF24 family HxlR-type putative transcriptional regulator; Protein involved in regulation of transcription, DNA-dependent.
cpdB protein networkhttps://string-db.org/network/511145.b42132':3'-cyclic-nucleotide 2'-phosphodiesterase; This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleoti [...]
cysQ protein networkhttps://string-db.org/network/511145.b42143'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has [...]
ytfI protein networkhttps://string-db.org/network/511145.b4215Uncharacterized protein.
ytfJ protein networkhttps://string-db.org/network/511145.b4216Putative transcriptional regulator.
ytfK protein networkhttps://string-db.org/network/511145.b4217DUF1107 family protein.
ytfL protein networkhttps://string-db.org/network/511145.b4218UPF0053 family inner membrane protein; Putative transport protein.
msrA protein networkhttps://string-db.org/network/511145.b4219Methionine sulfoxide reductase A; Could have an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methion [...]
tamA protein networkhttps://string-db.org/network/511145.b4220Translocation and assembly module for autotransporter export, outer membrane subunit; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in tran [...]
tamB protein networkhttps://string-db.org/network/511145.b4221Translocation and assembly module for autotransporter export, inner membrane subunit; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in tran [...]
ytfP protein networkhttps://string-db.org/network/511145.b4222GGCT-like protein; May play a role in antibiotic biosynthesis.
chpS protein networkhttps://string-db.org/network/511145.b4224Antitoxin of the ChpBS toxin-antitoxin system; Antitoxin component of a type II toxin-antitoxin (TA) system. May be involved in the regulation of cell growth. It acts as a suppressor of the endor [...]
chpB protein networkhttps://string-db.org/network/511145.b4225Toxin of the ChpB-ChpS toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. ChpB is a sequence-specific mRNA and (weak) tmRNA endoribonuclease that inhibits protein s [...]
ppa protein networkhttps://string-db.org/network/511145.b4226Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
ytfQ protein networkhttps://string-db.org/network/511145.b4227Galactofuranose ABC transporter periplasmic binding protein; Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Binds to both alpha- and beta- galac [...]
ytfT protein networkhttps://string-db.org/network/511145.b4230Putative sugar ABC transporter permease; Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Probably responsible for the translocation of the substr [...]
yjfF protein networkhttps://string-db.org/network/511145.b4231Putative sugar ABC transporter permease; Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Probably responsible for the translocation of the substr [...]
fbp protein networkhttps://string-db.org/network/511145.b4232Protein involved in gluconeogenesis.
mpl protein networkhttps://string-db.org/network/511145.b4233UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate [...]
yjgA protein networkhttps://string-db.org/network/511145.b4234Ribosome-associated UPF0307 family protein; Putative alpha helix protein; Protein involved in ATP-binding cassette (ABC) transporter activity.
pmbA protein networkhttps://string-db.org/network/511145.b4235Putative antibiotic peptide MccB17 maturation peptidase; Metalloprotease involved in CcdA degradation. Suppresses the inhibitory activity of the carbon storage regulator (CsrA).
nrdG protein networkhttps://string-db.org/network/511145.b4237Anaerobic ribonucleoside-triphosphate reductase-activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radic [...]
nrdD protein networkhttps://string-db.org/network/511145.b4238Anaerobic ribonucleoside-triphosphate reductase; Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Belongs to the anaerobic r [...]
treC protein networkhttps://string-db.org/network/511145.b4239trehalose-6-P hydrolase; Hydrolyzes trehalose-6-phosphate to glucose and glucose 6- phosphate. Can also very effectively hydrolyzes p-nitrophenyl-alpha-D- glucopyranoside, but it does not recogni [...]
treB protein networkhttps://string-db.org/network/511145.b4240Trehalose-specific PTS enzyme: IIB and IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the ph [...]
treR protein networkhttps://string-db.org/network/511145.b4241Trehalose 6-phosphate-inducible trehalose regulon transcriptional repressor; Repressor of the treBC operon. It is able to bind trehalose- 6-phosphate and trehalose.
mgtA protein networkhttps://string-db.org/network/511145.b4242Magnesium transporter; Mediates magnesium influx to the cytosol. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
ridA protein networkhttps://string-db.org/network/511145.b4243Enamine/imine deaminase, reaction intermediate detoxification; Accelerates the release of ammonia from reactive enamine/imine intermediates of the PLP-dependent threonine dehydratase (IlvA) in th [...]
pyrI protein networkhttps://string-db.org/network/511145.b4244Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase; Belongs to the PyrI family.
pyrB protein networkhttps://string-db.org/network/511145.b4245Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
pyrL protein networkhttps://string-db.org/network/511145.b4246pyrBI operon leader peptide; Protein involved in pyrimidine nucleotide biosynthetic process.
yjgH protein networkhttps://string-db.org/network/511145.b4248UPF0131 family protein; Protein involved in translation.
bdcA protein networkhttps://string-db.org/network/511145.b4249c-di-GMP-binding biofilm dispersal mediator protein; Increases biofilm dispersal. Acts by binding directly to the signaling molecule cyclic-di-GMP, which decreases the intracellular concentration [...]
bdcR protein networkhttps://string-db.org/network/511145.b4251Transcriptional repressor for divergent bdcA; Negatively regulates expression of bdcA.
tabA protein networkhttps://string-db.org/network/511145.b4252Biofilm modulator regulated by toxins; Influences biofilm formation. Represses fimbria genes in 8 hours biofilms. May act in response to the combined activity of several toxin-antitoxin (TA) syst [...]
yjgL protein networkhttps://string-db.org/network/511145.b4253SopA-central-domain-like hexapeptide repeat protein.
argI protein networkhttps://string-db.org/network/511145.b4254Ornithine carbamoyltransferase 1; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline, which i [...]
rraB protein networkhttps://string-db.org/network/511145.b4255Protein inhibitor of RNase E; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by [...]
yjgM protein networkhttps://string-db.org/network/511145.b4256GNAT family putative N-acetyltransferase; Putative acyltransferase; Belongs to the acetyltransferase family.
yjgN protein networkhttps://string-db.org/network/511145.b4257DUF898 family inner membrane protein.
valS protein networkhttps://string-db.org/network/511145.b4258valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors [...]
holC protein networkhttps://string-db.org/network/511145.b4259DNA polymerase III, chi subunit; Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DN [...]
pepA protein networkhttps://string-db.org/network/511145.b4260Cytosol aminopeptidase; Probably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Re [...]
lptF protein networkhttps://string-db.org/network/511145.b4261Lipopolysaccharide export ABC permease; Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
lptG protein networkhttps://string-db.org/network/511145.b4262Lipopolysaccharide export ABC permease; Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.
yjgR protein networkhttps://string-db.org/network/511145.b4263DUF853 family protein with NTPase fold; To E.coli YjiB.
idnR protein networkhttps://string-db.org/network/511145.b4264Transcriptional repressor, 5-gluconate-binding; Idn operon regulator. May repress gntKU and gntT genes when growing on L-idonate.
idnT protein networkhttps://string-db.org/network/511145.b4265L-idonate and D-gluconate transporter; Transports L-idonate, D-gluconate and 5-keto-D-gluconate, from the periplasm across the inner membrane.
idnO protein networkhttps://string-db.org/network/511145.b42665-keto-D-gluconate-5-reductase; Catalyzes the reduction of 5-keto-D-gluconate to D-gluconate, using either NADH or NADPH. Is likely involved in an L-idonate degradation pathway that allows E.coli [...]
idnD protein networkhttps://string-db.org/network/511145.b4267L-idonate 5-dehydrogenase, NAD-binding; Catalyzes the NADH/NADPH-dependent oxidation of L-idonate to 5-ketogluconate (5KG); Belongs to the zinc-containing alcohol dehydrogenase family.
idnK protein networkhttps://string-db.org/network/511145.b4268D-gluconate kinase, thermosensitive; Protein involved in carbohydrate catabolic process; Belongs to the gluconokinase GntK/GntV family.
ahr protein networkhttps://string-db.org/network/511145.b4269Broad specificity NADPH-dependent aldehyde reductase, Zn-containing; Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding al [...]
insC1-6 protein networkhttps://string-db.org/network/511145.b4272Pseudogene, integrase homology;IS, phage, Tn; Phage-related functions and prophages; KpLE2 phage-like element; P4-like integrase.
insD1-6 protein networkhttps://string-db.org/network/511145.b4273IS2 transposase TnpB.
yjgZ protein networkhttps://string-db.org/network/511145.b4277Uncharacterized protein YjgZ; Pseudogene fragment.
insG protein networkhttps://string-db.org/network/511145.b4278IS4 transposase; Involved in the transposition of the insertion sequence IS4.
yjhB protein networkhttps://string-db.org/network/511145.b4279Putative MFS transporter, membrane protein; Putative transport protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
yjhC protein networkhttps://string-db.org/network/511145.b4280GFO/IDH/MOCA family putative oxidoreductase. NAD(P)-dependent; Putative dehydrogenase; Belongs to the Gfo/Idh/MocA family.
insI1-3 protein networkhttps://string-db.org/network/511145.b4284Pseudogene, IS911 transposase B;IS, phage, Tn; Transposon-related functions; extrachromosomal; transposon related.
fecE protein networkhttps://string-db.org/network/511145.b4287Fe(3+) dicitrate transport ATP-binding protein FecE; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport [...]
fecD protein networkhttps://string-db.org/network/511145.b4288Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across th [...]
fecC protein networkhttps://string-db.org/network/511145.b4289Ferric citrate ABC transporter permease; Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across th [...]
fecB protein networkhttps://string-db.org/network/511145.b4290Ferric citrate ABC transporter periplasmic binding protein; Binds citrate-dependent Fe(3+); part of the binding-protein- dependent transport system for uptake of citrate-dependent Fe(3+).
fecA protein networkhttps://string-db.org/network/511145.b4291TonB-dependent outer membrane ferric citrate transporter and signal transducer; FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system.
fecR protein networkhttps://string-db.org/network/511145.b4292Anti-sigma transmembrane signal transducer for ferric citrate transport; Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a sensor that re [...]
fecI protein networkhttps://string-db.org/network/511145.b4293RNA polymerase sigma-19 factor, fec operon-specific; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This si [...]
insA-6 protein networkhttps://string-db.org/network/511145.b4294IS1 repressor TnpA; Absolutely required for transposition of IS1.
yjhU protein networkhttps://string-db.org/network/511145.b4295Uncharacterized transcriptional regulator YjhU; IS1 transposase B;IS, phage, Tn; Transposon-related functions; extrachromosomal; transposon related; Belongs to the SorC transcriptional regulatory [...]
yjhF protein networkhttps://string-db.org/network/511145.b4296Putative transport system permease.
yjhG protein networkhttps://string-db.org/network/511145.b4297Putative dehydratase; Catalyzes the dehydration of D-xylonic acid to form 2- dehydro-3-deoxy-D-pentonate.
yjhH protein networkhttps://string-db.org/network/511145.b4298Putative lyase/synthase; Functions as a 2-dehydro-3-deoxy-D-pentonate aldolase. Belongs to the DapA family.
yjhI protein networkhttps://string-db.org/network/511145.b4299Putative regulator; Protein involved in transcription repressor activity and transcription.
sgcR protein networkhttps://string-db.org/network/511145.b4300Putative DNA-binding transcriptional regulator; Putative transcriptional regulator for the sgcREAQCX region.
sgcE protein networkhttps://string-db.org/network/511145.b4301Putative epimerase; Probable pentose-5-phosphate 3-epimerase.
sgcA protein networkhttps://string-db.org/network/511145.b4302Putative phosphotransferase enzyme IIA component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosp [...]
sgcQ protein networkhttps://string-db.org/network/511145.b4303Putative nucleoside triphosphatase; Belongs to the BtpA family.
sgcC protein networkhttps://string-db.org/network/511145.b4304Putative PTS system EIIC permease component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation [...]
sgcX protein networkhttps://string-db.org/network/511145.b4305Putative endoglucanase with Zn-dependent exopeptidase domain; Putative lyase/synthase.
yjhP protein networkhttps://string-db.org/network/511145.b4306Uncharacterized protein YjhP; Pseudogene, zinc finger protein family.
yjhQ protein networkhttps://string-db.org/network/511145.b4307GNAT family putative N-acetyltransferase; Protein involved in RNA metabolic process; Belongs to the acetyltransferase family.
nanS protein networkhttps://string-db.org/network/511145.b4309Probable 9-O-acetyl-N-acetylneuraminic acid deacetylase; Probably catalyzes the hydrolysis of the 9-O-acetyl group of 9-O-acetyl-N-acetylneuraminate (Neu5,9Ac2). Is required for growth of E.coli [...]
nanM protein networkhttps://string-db.org/network/511145.b4310N-acetylneuraminic acid mutarotase; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates si [...]
nanC protein networkhttps://string-db.org/network/511145.b4311N-acetylnuraminic acid outer membrane channel protein; Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) [...]
fimB protein networkhttps://string-db.org/network/511145.b4312Tyrosine recombinase/inversion of on/off regulator of fimA; FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the per [...]
fimE protein networkhttps://string-db.org/network/511145.b4313Tyrosine recombinase/inversion of on/off regulator of fimA; FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the per [...]
fimA protein networkhttps://string-db.org/network/511145.b4314Major type 1 subunit fimbrin (pilin); Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, e [...]
fimI protein networkhttps://string-db.org/network/511145.b4315Fimbrial protein; Protein involved in glycoprotein biosynthetic process.
fimC protein networkhttps://string-db.org/network/511145.b4316Periplasmic chaperone; Required for the biogenesis of type 1 fimbriae. Binds and interact with FimH.
fimD protein networkhttps://string-db.org/network/511145.b4317Fimbrial usher outer membrane porin protein; Involved in the export and assembly of FimA fimbrial subunits across the outer membrane.
fimF protein networkhttps://string-db.org/network/511145.b4318Minor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration o [...]
fimG protein networkhttps://string-db.org/network/511145.b4319Minor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration o [...]
fimH protein networkhttps://string-db.org/network/511145.b4320Minor component of type 1 fimbriae; Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the b [...]
gntP protein networkhttps://string-db.org/network/511145.b4321Fructuronate transporter; High-affinity gluconate transporter with fairly broad specificity, including low affinity for glucuronate, several disaccharides, and some hexoses, but not glucose.
uxuA protein networkhttps://string-db.org/network/511145.b4322Mannonate hydrolase; Catalyzes the dehydration of D-mannonate.
uxuB protein networkhttps://string-db.org/network/511145.b4323D-mannonate oxidoreductase, NAD-dependent; D-mannonate oxidoreductase; Protein involved in carbohydrate catabolic process; Belongs to the mannitol dehydrogenase family. UxuB subfamily.
uxuR protein networkhttps://string-db.org/network/511145.b4324Fructuronate-inducible hexuronate regulon transcriptional repressor; Repressor for the uxuRBA operon.
yjiC protein networkhttps://string-db.org/network/511145.b4325Uncharacterized protein; To E.coli YjfZ.
iraD protein networkhttps://string-db.org/network/511145.b4326RpoS stabilzer after DNA damage, anti-RssB factor; Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. [...]
hypT protein networkhttps://string-db.org/network/511145.b4327Hypochlorite-responsive transcription factor; Protects cells from HOCl (hypochlorite) stress but not peroxide or diamide stress. Decreases the intracellular load of reactive oxygen species by up- [...]
iadA protein networkhttps://string-db.org/network/511145.b4328Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The be [...]
yjiG protein networkhttps://string-db.org/network/511145.b4329SpmB family inner membrane protein.
yjiH protein networkhttps://string-db.org/network/511145.b4330Nucleoside recognition pore and gate family putative inner membrane transporter.
kptA protein networkhttps://string-db.org/network/511145.b4331RNA 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and [...]
yjiJ protein networkhttps://string-db.org/network/511145.b4332DUF1228 family putative inner membrane MFS superfamily transporter; Putative transport protein.
yjiK protein networkhttps://string-db.org/network/511145.b4333SdiA-regulated family putative membrane-anchored protein; putative phytase-like esterase.
yjiL protein networkhttps://string-db.org/network/511145.b4334Putative ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase; Putative enzyme.
yjiM protein networkhttps://string-db.org/network/511145.b4335Putative 2-hydroxyglutaryl-CoA dehydratase; Belongs to the FldB/FldC dehydratase alpha/beta subunit family.
yjiN protein networkhttps://string-db.org/network/511145.b4336Zinc-type alcohol dehydrogenase-like protein.
mdtM protein networkhttps://string-db.org/network/511145.b4337Multidrug efflux system protein; Confers resistance to acriflavine, chloramphenicol, norfloxacin, ethidium bromide and TPP; Belongs to the major facilitator superfamily.
yjiR protein networkhttps://string-db.org/network/511145.b4340Uncharacterized HTH-type transcriptional regulator YjiR; RIP347 (repetitive extragenic palindromic) element; contains 2 REP sequences and 1 IHF site; In the C-terminal section; belongs to the cla [...]
yjiS protein networkhttps://string-db.org/network/511145.b4341DUF1127 family protein.
mcrC protein networkhttps://string-db.org/network/511145.b4345Protein McrC; Modifies the specificity of McrB restriction by expanding the range of modified sequences restricted. Does not bind to DNA.
mcrB protein networkhttps://string-db.org/network/511145.b43465-methylcytosine-specific restriction enzyme McrBC, subunit McrB; Recognizes N4- and C5-methylcytosine (and 5-hydroxy- methylcytosines) produced by a broad range of DNA methylases and appears to [...]
symE protein networkhttps://string-db.org/network/511145.b4347Toxic peptide regulated by antisense sRNA symR; Toxic component of a type I toxin-antitoxin (TA) system. Involved in the degradation and recycling of damaged RNA. It is itself a target for degrad [...]
hsdS protein networkhttps://string-db.org/network/511145.b4348Specificity determinant for hsdM and hsdR; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognit [...]
hsdM protein networkhttps://string-db.org/network/511145.b4349DNA methyltransferase M; The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In t [...]
hsdR protein networkhttps://string-db.org/network/511145.b4350Endonuclease R Type I restriction enzyme; The EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification; Belongs to the Hs [...]
mrr protein networkhttps://string-db.org/network/511145.b4351Methylated adenine and cytosine restriction protein; Involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA.
yjiA protein networkhttps://string-db.org/network/511145.b4352Metal-binding GTPase; Binds GTP and has low GTPase activity. May have a GTP- dependent regulatory function; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.
yjiX protein networkhttps://string-db.org/network/511145.b4353DUF466 family protein; To E.coli YbdD.
yjiY protein networkhttps://string-db.org/network/511145.b4354Putative transporter; Transports pyruvate with a high affinity and specificity. The process is driven by the proton motive force. Part of a nutrient-sensing regulatory network composed of the two [...]
tsr protein networkhttps://string-db.org/network/511145.b4355Methyl-accepting chemotaxis protein I, serine sensor receptor; Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellent [...]
lgoT protein networkhttps://string-db.org/network/511145.b4356Putative L-galactonate:H+ symporter; Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L- galactonate as the sole ca [...]
lgoR protein networkhttps://string-db.org/network/511145.b4357Putative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon sour [...]
lgoD protein networkhttps://string-db.org/network/511145.b4358L-galactonate oxidoreductase; Catalyzes the oxidation of L-galactonate to D-tagaturonate. Required for growth on L-galactonate as the sole carbon source. In vitro, can also use L-gulonate.
opgB protein networkhttps://string-db.org/network/511145.b4359OPG periplasmic biosynthetic phosphoglycerol transferases I (membrane-bound) and II (soluble); Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan b [...]
yjjA protein networkhttps://string-db.org/network/511145.b4360Putative DUF2501 family periplasmic protein; Putative glycoprotein/receptor.
dnaC protein networkhttps://string-db.org/network/511145.b4361DNA biosynthesis protein; This protein is required for chromosomal replication. It forms, in concert with DnaB protein and other prepriming proteins DnaT, N, N', N'' a prepriming protein complex [...]
dnaT protein networkhttps://string-db.org/network/511145.b4362DNA biosynthesis protein (primosomal protein I); This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS respons [...]
yjjB protein networkhttps://string-db.org/network/511145.b4363DUF3815 family inner membrane protein.
yjjP protein networkhttps://string-db.org/network/511145.b4364DUF1212 family inner membrane protein; Putative structural protein; To H.influenzae HI_0108.
yjjQ protein networkhttps://string-db.org/network/511145.b4365Putative regulator.
bglJ protein networkhttps://string-db.org/network/511145.b4366Bgl operon transcriptional activator; A crytic transcriptional activator. When its expression is induced it relieves H-NS repression of the bgl operon. Acts independently of transcription factor [...]
fhuF protein networkhttps://string-db.org/network/511145.b4367Ferric iron reductase involved in ferric hydroximate transport; Involved in the reduction of ferric iron in cytoplasmic ferrioxamine B.
rsmC protein networkhttps://string-db.org/network/511145.b437116S rRNA m(2)G1207 methyltransferase, SAM-dependent; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
holD protein networkhttps://string-db.org/network/511145.b4372DNA polymerase III, psi subunit; Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex. DN [...]
rimI protein networkhttps://string-db.org/network/511145.b4373ribosomal-protein-S18-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. Also acts as a N-epsilon-lysine acetyltransferase that catalyzes acetylation of seve [...]
yjjG protein networkhttps://string-db.org/network/511145.b4374dUMP phosphatase; Nucleotidase that shows high phosphatase activity toward non- canonical pyrimidine nucleotides and three canonical nucleoside 5'- monophosphates (UMP, dUMP, and dTMP), and very [...]
prfC protein networkhttps://string-db.org/network/511145.b4375Peptide chain release factor RF-3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference fo [...]
osmY protein networkhttps://string-db.org/network/511145.b4376Salt-inducible putative ABC transporter periplasmic binding protein; Hyperosmotically inducible periplasmic protein; Protein involved in response to osmotic stress.
yjjU protein networkhttps://string-db.org/network/511145.b4377Putative patatin-like family phospholipase; Probable lipid hydrolase.
yjjV protein networkhttps://string-db.org/network/511145.b4378Putative DNase; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
yjjW protein networkhttps://string-db.org/network/511145.b4379Putative activating enzyme; Protein involved in anaerobic respiration and protein modification process; Belongs to the organic radical-activating enzymes family.
yjjI protein networkhttps://string-db.org/network/511145.b4380DUF3029 family protein, putative glycine radical enzyme.
deoC protein networkhttps://string-db.org/network/511145.b43812-deoxyribose-5-phosphate aldolase, NAD(P)-linked; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Can also [...]
deoA protein networkhttps://string-db.org/network/511145.b4382Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon a [...]
deoB protein networkhttps://string-db.org/network/511145.b4383Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.
deoD protein networkhttps://string-db.org/network/511145.b4384Purine nucleoside phosphorylase 1; Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules.
yjjJ protein networkhttps://string-db.org/network/511145.b4385Putative protein kinase; Toxic when overexpressed in E.coli, leading to long filamentous cells. The toxic effect is neutralized by non-cognate antitoxin HipB. Does not seem to inhibit DNA, RNA or [...]
lplA protein networkhttps://string-db.org/network/511145.b4386Lipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dep [...]
ytjB protein networkhttps://string-db.org/network/511145.b4387SMP_2 family putative membrane-anchored periplasmic protein; Belongs to the Smp family.
serB protein networkhttps://string-db.org/network/511145.b43883-phosphoserine phosphatase; Catalyzes the dephosphorylation of phosphoserine (P-Ser). Also catalyzes the hydrolysis of phosphothreonine (P-Thr). Belongs to the HAD-like hydrolase superfamily. Se [...]
radA protein networkhttps://string-db.org/network/511145.b4389DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand trans [...]
nadR protein networkhttps://string-db.org/network/511145.b4390Trifunctional NAD biosynthesis/regulator protein NadR; This enzyme has three activities: DNA binding, nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. Th [...]
ettA protein networkhttps://string-db.org/network/511145.b4391Energy-dependent translational throttle A; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation e [...]
slt protein networkhttps://string-db.org/network/511145.b4392Lytic murein transglycosylase, soluble; Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan. May [...]
trpR protein networkhttps://string-db.org/network/511145.b4393Transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the [...]
yjjX protein networkhttps://string-db.org/network/511145.b4394Non-canonical purine NTP phosphatase, ITPase/XTPase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably exclude [...]
ytjC protein networkhttps://string-db.org/network/511145.b4395Phosphatase; Phosphoglyceromutase 2; Protein involved in glycolysis and gluconeogenesis; Belongs to the phosphoglycerate mutase family. GpmB subfamily.
rob protein networkhttps://string-db.org/network/511145.b4396Right oriC-binding transcriptional activator, AraC family; Binds to the right arm of the replication origin oriC of the chromosome. Rob binding may influence the formation of the nucleoprotein st [...]
creA protein networkhttps://string-db.org/network/511145.b4397Putative periplasmic protein.
creB protein networkhttps://string-db.org/network/511145.b4398Response regulator in two-component regulatory system with CreC; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation.
creC protein networkhttps://string-db.org/network/511145.b4399Sensory histidine kinase in two-component regulatory system with CreB or PhoB; Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a mem [...]
creD protein networkhttps://string-db.org/network/511145.b4400Inner membrane protein; Tolerance to colicin E2.
arcA protein networkhttps://string-db.org/network/511145.b4401Response regulator in two-component regulatory system with ArcB or CpxA; Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic condi [...]
yjjY protein networkhttps://string-db.org/network/511145.b4402Uncharacterized protein.
yjtD protein networkhttps://string-db.org/network/511145.b4403Putative methyltransferase; Protein involved in RNA modification; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
yaeP protein networkhttps://string-db.org/network/511145.b4406UPF0253 family protein; Belongs to the UPF0253 family.
thiS protein networkhttps://string-db.org/network/511145.b4407Immediate sulfur donor in thiazole formation; Is the sulfur donor in the synthesis of the thiazole phosphate moiety of thiamine phosphate.
blr protein networkhttps://string-db.org/network/511145.b4409Beta-lactam resistance membrane protein; Component of the cell division machinery, which is probably involved in the stabilization of the divisome under certain stress conditions.
ecnA protein networkhttps://string-db.org/network/511145.b4410Entericidin A membrane lipoprotein, antidote entericidin B; Acts as antidote to the effect of entericidin B; Belongs to the EcnA/EcnB lipoprotein family.
ecnB protein networkhttps://string-db.org/network/511145.b4411Entericidin B membrane lipoprotein; Plays a role in the bacteriolysis. Is activated under conditions of high osmolarity by the factor sigma S. Entericidin A functions as an antidote; Belongs to t [...]
hokC protein networkhttps://string-db.org/network/511145.b4412Small toxic membrane polypeptide; completely contained in another CDS.
hokE protein networkhttps://string-db.org/network/511145.b4415Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system; if it expressed it could be neutralized by antisense antitoxin RNA SokE. Belongs to the Hok/Gef family.
ldrA protein networkhttps://string-db.org/network/511145.b4419Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Inhibits ATP synthesis possibly due to its insertion in the cell inner membrane, ATP levels drop over 50% 2 minu [...]
ldrB protein networkhttps://string-db.org/network/511145.b4421Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing, probably by disrupting the cell inner membrane and disruption of ATP s [...]
ldrC protein networkhttps://string-db.org/network/511145.b4423Small toxic polypeptide.
hokB protein networkhttps://string-db.org/network/511145.b4428Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arr [...]
ldrD protein networkhttps://string-db.org/network/511145.b4453Toxic polypeptide, small; Toxic component of a type I toxin-antitoxin (TA) system. Overexpression causes rapid cell killing and nucleoid condensation of the host cell. Overexpression induces stre [...]
hokA protein networkhttps://string-db.org/network/511145.b4455Protein HokA; Toxic component of a type I toxin-antitoxin (TA) system (Probable). When overexpressed kills cells within minutes; causes collapse of the transmembrane potential and arrest of respi [...]
araH protein networkhttps://string-db.org/network/511145.b4460L-arabinose ABC transporter permease; Part of the binding-protein-dependent transport system for L- arabinose. Probably responsible for the translocation of the substrate across the membrane.
yfjD protein networkhttps://string-db.org/network/511145.b4461UPF0053 family inner membrane protein; Putative membrane protein.
ygcU protein networkhttps://string-db.org/network/511145.b4463Putative FAD-linked oxidoreductase; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
ghxQ protein networkhttps://string-db.org/network/511145.b4464Guanine/hypoxanthine permease, high affinity; High-affinity transporter for guanine and hypoxanthine.
yggP protein networkhttps://string-db.org/network/511145.b4465Putative Zn-binding dehydrogenase; To K.pneumoniae SorE.
sslE protein networkhttps://string-db.org/network/511145.b4466Putative secreted and surface-associated lipoprotein mucinase; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the [...]
glcF protein networkhttps://string-db.org/network/511145.b4467Glycolate oxidase 4Fe-4S iron-sulfur cluster subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source [...]
glcE protein networkhttps://string-db.org/network/511145.b4468Glycolate oxidase FAD binding subunit; Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. Is required for E.coli to grow on glycolate as a sole source of carbon. Is a [...]
ygiQ protein networkhttps://string-db.org/network/511145.b4469Radical SAM superfamily protein.
yhaM protein networkhttps://string-db.org/network/511145.b4470Putative L-serine dehydratase alpha chain; Plays a role in L-cysteine detoxification; it has been speculated to be a cysteine desulfhydrase.
tdcG protein networkhttps://string-db.org/network/511145.b4471L-serine dehydratase; Protein involved in cellular amino acid catabolic process.
yhdP protein networkhttps://string-db.org/network/511145.b4472DUF3971-AsmA2 domains protein.
smf protein networkhttps://string-db.org/network/511145.b4473DNA recombination-mediator A family protein; Partially complements natural chromosomal DNA transformation defect of an H.influenzae dprA disruption mutant. May help load RecA onto ssDNA (By simil [...]
frlC protein networkhttps://string-db.org/network/511145.b4474Fructoselysine 3-epimerase; Catalyzes the reversible interconversion of fructoselysine with its C-3 epimer, psicoselysine. Allows E.coli to utilize psicoselysine for growth. Does not act on psico [...]
rtcA protein networkhttps://string-db.org/network/511145.b4475RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenyl [...]
gntU protein networkhttps://string-db.org/network/511145.b4476Gluconate transporter, low affinity GNT 1 system; Part of the gluconate utilization system Gnt-I; low-affinity intake of gluconate; Belongs to the GntP permease family.
dgoA protein networkhttps://string-db.org/network/511145.b44772-oxo-3-deoxygalactonate 6-phosphate aldolase; Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the reversible, stereospecific retro-aldol cleavage of 2-keto-3 [...]
dgoD protein networkhttps://string-db.org/network/511145.b4478D-galactonate dehydratase; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate.
dgoR protein networkhttps://string-db.org/network/511145.b4479D-galactonate catabolism operon transcriptional repressor; Repressor for the dgoRKAT operon. Binds D-galactonate as an inducer.
hdfR protein networkhttps://string-db.org/network/511145.b4480flhDC operon transcriptional repressor; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. Belongs to the LysR transcript [...]
wecF protein networkhttps://string-db.org/network/511145.b4481TDP-Fuc4NAc:lipidIIFuc4NAc transferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosy [...]
yigE protein networkhttps://string-db.org/network/511145.b4482DUF2233 family protein.
tatD protein networkhttps://string-db.org/network/511145.b4483Quality control of Tat-exported FeS proteins; 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. Belongs to the metallo-depende [...]
cpxP protein networkhttps://string-db.org/network/511145.b4484Inhibitor of the cpx response; Acts as an auxiliary protein in the Cpx two-component envelope stress response system, helping modulate the Cpx response systems response to some inducers. Binds th [...]
ytfR protein networkhttps://string-db.org/network/511145.b4485Putative sugar ABC transporter ATPase; Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Responsible for energy coupling to the transport system (P [...]
yjdP protein networkhttps://string-db.org/network/511145.b4487Putative periplasmic protein; Conserved hypothetical protein; conserved in EDL933 and CFT073; on opposite strand of the now deaccessioned phnQ (b4091).
torI protein networkhttps://string-db.org/network/511145.b4501Response regulator inhibitor for tor operon; Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excisi [...]
yeiW protein networkhttps://string-db.org/network/511145.b4502UPF0153 cysteine cluster protein.
ykfH protein networkhttps://string-db.org/network/511145.b4504Uncharacterized protein; Belongs to the YeeT/YkfH/YpjJ family.
ykgO protein networkhttps://string-db.org/network/511145.b4506RpmJ-like protein.
ylcG protein networkhttps://string-db.org/network/511145.b4509Uncharacterized protein, DLP12 prophage.
rzoD protein networkhttps://string-db.org/network/511145.b4510DLP12 prophage; Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in cell lysis by disrupting th [...]
ybdZ protein networkhttps://string-db.org/network/511145.b4511Stimulator of EntF adenylation activity, MbtH-like; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoy [...]
ybdD protein networkhttps://string-db.org/network/511145.b4512DUF466 family protein; To E.coli YjiX.
kdpF protein networkhttps://string-db.org/network/511145.b4513Potassium ion accessory transporter subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transpor [...]
cydX protein networkhttps://string-db.org/network/511145.b4515Cytochrome d (bd-I) ubiquinol oxidase subunit X; Required for correct functioning of cytochrome bd-I oxidase. This protein and AppX may have some functional overlap.
insA-7 protein networkhttps://string-db.org/network/511145.b4516IS1 repressor TnpA.
gnsA protein networkhttps://string-db.org/network/511145.b4517Putative phosphatidylethanolamine synthesis regulator; Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold- sensitive [...]
ymdF protein networkhttps://string-db.org/network/511145.b4518KGG family protein; Belongs to the con-10 family.
ymgF protein networkhttps://string-db.org/network/511145.b4520Inner membrane division septum protein; Could be involved in cell division. May participate in the stabilization of the cell divisome under specific conditions.
ymiA protein networkhttps://string-db.org/network/511145.b4522Uncharacterized protein.
yciX protein networkhttps://string-db.org/network/511145.b4523Uncharacterized protein.
ydaE protein networkhttps://string-db.org/network/511145.b4526Conserved protein, Rac prophage.
ydaF protein networkhttps://string-db.org/network/511145.b4527Uncharacterized protein, Rac prophage; To E.coli YdfA.
rzoR protein networkhttps://string-db.org/network/511145.b4528Prophage outer membrane lipoprotein RzoR; Component of the spanin complex that disrupts the outer membrane and causes cell lysis during virus exit. The spanin complex conducts the final step in c [...]
ydbJ protein networkhttps://string-db.org/network/511145.b4529DUF333 family putative lipoprotein.
hicA protein networkhttps://string-db.org/network/511145.b4532mRNA interferase toxin of the HicAB toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. A probable translation-independent mRNA interferase. Overexpression causes ce [...]
ynfO protein networkhttps://string-db.org/network/511145.b4533Uncharacterized protein YnfO; Pseudogene, Qin prophage; Phage DNA packaging protein Nu1 family;Phage or Prophage Related; DNA packaging protein NU1 homolog from lambdoid prophage Qin.
yniD protein networkhttps://string-db.org/network/511145.b4535Uncharacterized protein YniD; Pseudogene, ankyrin repeats.
yobH protein networkhttps://string-db.org/network/511145.b4536Uncharacterized protein.
yecJ protein networkhttps://string-db.org/network/511145.b4537DUF2766 family protein.
yoeB protein networkhttps://string-db.org/network/511145.b4539Toxin of the YoeB-YefM toxin-antitoxin system; Toxic component of a type II toxin-antitoxin (TA) system. Its mode of function is controversial; it has been proposed to be an mRNA interferase but [...]
yehK protein networkhttps://string-db.org/network/511145.b4541Uncharacterized protein.
yohO protein networkhttps://string-db.org/network/511145.b4542Putative membrane protein; Belongs to the UPF0387 family.
arnE protein networkhttps://string-db.org/network/511145.b4544Undecaprenyl phosphate-alpha-L-ara4N exporter; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the [...]
ypeB protein networkhttps://string-db.org/network/511145.b4546DUF3820 family protein.
ypfN protein networkhttps://string-db.org/network/511145.b4547Putative membrane protein, UPF0370 family.
ypjJ protein networkhttps://string-db.org/network/511145.b4548Uncharacterized protein; Belongs to the YeeT/YkfH/YpjJ family.
arfA protein networkhttps://string-db.org/network/511145.b4550Alternate ribosome-rescue factor A; Rescues ribosomes stalled at the 3' end of non-stop mRNAs. This activity is crucial when the stalled ribosome cannot be rescued by the SsrA(tmRNA)-SmpB quality [...]
yheV protein networkhttps://string-db.org/network/511145.b4551DUF2387 family putative metal-binding protein.
ysaB protein networkhttps://string-db.org/network/511145.b4553Uncharacterized protein.
yibT protein networkhttps://string-db.org/network/511145.b4554Uncharacterized protein.
yicS protein networkhttps://string-db.org/network/511145.b4555Putative periplasmic protein.
yidD protein networkhttps://string-db.org/network/511145.b4557Membrane protein insertion efficiency factor, UPF0161 family inner membrane protein; Could be involved in insertion of integral membrane proteins into the membrane.
yifL protein networkhttps://string-db.org/network/511145.b4558Putative lipoprotein.
ghoT protein networkhttps://string-db.org/network/511145.b4559Toxin of GhoTS toxin-antitoxin pair; Toxic component of a type V toxin-antitoxin (TA) system. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dorm [...]
sgcB protein networkhttps://string-db.org/network/511145.b4565Putative enzyme IIB component of PTS; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation o [...]
yjhX protein networkhttps://string-db.org/network/511145.b4566UPF0386 family protein; Belongs to the UPF0386 family.
yjjZ protein networkhttps://string-db.org/network/511145.b4567Uncharacterized protein.
ytjA protein networkhttps://string-db.org/network/511145.b4568Uncharacterized protein.
ylbE protein networkhttps://string-db.org/network/511145.b4572NO-induced DUF1116 protein; To E.coli YahG.
ykfM protein networkhttps://string-db.org/network/511145.b4586Lethality reduction protein, putative inner membrane protein.
ylcH protein networkhttps://string-db.org/network/511145.b4588Uncharacterized protein, DLP12 prophage.
ylcI protein networkhttps://string-db.org/network/511145.b4589DUF3950 family protein, DLP12 prophage.
ybfK protein networkhttps://string-db.org/network/511145.b4590Uncharacterized protein.
cbdX protein networkhttps://string-db.org/network/511145.b4592Putative cytochrome bd-II oxidase subunit; Might be part of cytochrome bd-II oxidase (appB and appC). Able to restore reductant resistance to a cydX deletion mutant upon overexpression. CydX and [...]
ymgI protein networkhttps://string-db.org/network/511145.b4593Uncharacterized protein.
ymgJ protein networkhttps://string-db.org/network/511145.b4594Uncharacterized protein.
yciY protein networkhttps://string-db.org/network/511145.b4595Uncharacterized protein; Belongs to the YciY family.
yciZ protein networkhttps://string-db.org/network/511145.b4596Uncharacterized protein.
yncL protein networkhttps://string-db.org/network/511145.b4598Stress-induced small inner membrane enterobacterial protein.
yneM protein networkhttps://string-db.org/network/511145.b4599Inner membrane-associated protein; Modulates intracellular Mg(2+) levels to maintain cellular integrity upon Mg(2+) limitation. Acts by binding and stabilizing the Mg(2+) transporter MgtA, thereb [...]
ydgU protein networkhttps://string-db.org/network/511145.b4601Stationary phase-induced protein.
ynhF protein networkhttps://string-db.org/network/511145.b4602Stress response membrane.
ypfM protein networkhttps://string-db.org/network/511145.b4606Stress-induced small enterobacterial protein.
dinQ protein networkhttps://string-db.org/network/511145.b4613UV-inducible membrane toxin, DinQ-AgrB type I toxin-antitoxin system; Belongs to the DinQ family.
tisB protein networkhttps://string-db.org/network/511145.b4618Toxic membrane persister formation peptide, LexA-regulated; Toxic component of a type I toxin-antitoxin (TA) system (Probable). Overexpression causes cessation of growth, induces stress-response [...]
yjbT protein networkhttps://string-db.org/network/511145.b4620Putative periplasmic protein; Belongs to the YjbT family.
yjbS protein networkhttps://string-db.org/network/511145.b4621Uncharacterized protein.
ytcA protein networkhttps://string-db.org/network/511145.b4622Putative inner membrane efflux pump-associated DUF1656 family protein.
uof protein networkhttps://string-db.org/network/511145.b4637ryhB-regulated fur leader peptide; Cotranscribed with fur, it is essential for fur translation. The fur ribosomal binding site (RBS) is occluded by the 5'-mRNA secondary structure, which is opene [...]
ythA protein networkhttps://string-db.org/network/511145.b4655Uncharacterized protein.
sgrT protein networkhttps://string-db.org/network/511145.b4662Inhibitor of glucose uptake; Acts to promote recovery from glucose-phosphate stress due to intracellular accumulation of glucose-6-phosphate caused by disruption of glycolytic flux or in the pres [...]
azuC protein networkhttps://string-db.org/network/511145.b4663Acid-inducible small membrane-associated protein.
ibsD protein networkhttps://string-db.org/network/511145.b4664Toxic membrane protein.
ibsC protein networkhttps://string-db.org/network/511145.b4665Toxic membrane protein.
ibsE protein networkhttps://string-db.org/network/511145.b4666Toxic membrane protein.
ibsA protein networkhttps://string-db.org/network/511145.b4667Toxic membrane protein.
ibsB protein networkhttps://string-db.org/network/511145.b4668Toxic membrane protein.
ilvX protein networkhttps://string-db.org/network/511145.b4669Uncharacterized protein.
yjeV protein networkhttps://string-db.org/network/511145.b4670Uncharacterized protein.
ykgR protein networkhttps://string-db.org/network/511145.b4671Uncharacterized protein.
ymiB protein networkhttps://string-db.org/network/511145.b4672Uncharacterized protein.
ynbG protein networkhttps://string-db.org/network/511145.b4674Uncharacterized protein.
yoaJ protein networkhttps://string-db.org/network/511145.b4675Inner membrane-associated protein.
yoaK protein networkhttps://string-db.org/network/511145.b4676Inner membrane-associated protein.
yobI protein networkhttps://string-db.org/network/511145.b4677Uncharacterized protein.
yoeI protein networkhttps://string-db.org/network/511145.b4678Uncharacterized protein.
yohP protein networkhttps://string-db.org/network/511145.b4679Uncharacterized membrane protein YohP; Pseudogene; putative channel/filament proteins.
ypdK protein networkhttps://string-db.org/network/511145.b4680Inner membrane protein.
yqcG protein networkhttps://string-db.org/network/511145.b4682Membrane stress resistance protein.
yqeL protein networkhttps://string-db.org/network/511145.b4683Uncharacterized protein.
yqfG protein networkhttps://string-db.org/network/511145.b4684Uncharacterized protein.
yrbN protein networkhttps://string-db.org/network/511145.b4685Uncharacterized protein.
yshB protein networkhttps://string-db.org/network/511145.b4686Uncharacterized protein.
shoB protein networkhttps://string-db.org/network/511145.b4687Toxic membrane protein; Toxic component of a type I toxin-antitoxin (TA) system. May be a toxic protein; overexpression causes cessation of growth and rapid membrane depolarization. Overexpressio [...]
rzoQ protein networkhttps://string-db.org/network/511145.b4689Putative Rz1-like lipoprotein, Qin prophage; Completely contained in another CDS.
mgtL protein networkhttps://string-db.org/network/511145.b4702Regulatory leader peptide for mgtA; Makes mgtA transcription sensitive to intracellular proline levels. Under low levels of proline this protein cannot be fully translated, and a stem loop forms [...]
pmrR protein networkhttps://string-db.org/network/511145.b4703Putative membrane-bound BasS regulator; May bind to BasS and modulate its sensor kinase activity.
mntS protein networkhttps://string-db.org/network/511145.b4705Mn(2)-response protein, MntR-repressed; Required for repression of mntH by MntR. May function as a chaperone that makes manganese more available by delivering it to the necessary cellular locatio [...]
iroK protein networkhttps://string-db.org/network/511145.b47063-hydroxypropionic acid resistance peptide; Completely contained in another CDS.